MUC4 Gene
protein-coding GIFtS: 59
GCID: GC03M195473
|
|
mucin 4, cell surface associated(Previous names: mucin 4, tracheobronchial )
| |
Aliases
for MUC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mucin 4, Cell Surface Associated1 2 | | Tracheobronchial Mucin2 3 | | Mucin 4, Tracheobronchial1 2 | | ASGP2 3 | | Ascites Sialoglycoprotein2 3 | | MUC-42 3 | | Pancreatic Adenocarcinoma Mucin2 3 | | HSA2763592 | | Testis Mucin2 3 | | Mucin-41 |
Export aliases for MUC4 gene to outside databasesPrevious GC identifers: GC03P191251 GC03P195544 GC03M196882 GC03M196801 GC03M196963 GC03M192745 |
Summaries
for MUC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MUC4:
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea,colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in theprotection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This geneencodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At leasttwo dozen transcript variants of this gene have been found, although for many of them the full-length transcript hasnot been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence whichhas a variable number (>100) of 48 nt tandem repeats. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102Function: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression ofapoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through bothanti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as anintramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cellsby inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of theERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 fromacting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of aMUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulationof proliferation
Gene Wiki entry for MUC4
|
Genomic Views
for MUC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_029928.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MUC4 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for MUC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29MUC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M195473: view genomic region
(about GC identifiers)
Start:
|
195,473,636 bp from pter |
End:
|
195,539,148 bp from pter |
Size:
|
65,513 bases |
Orientation:
|
minus strand |
|
Proteins
for MUC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102 (See
protein sequence)Recommended Name: Mucin-4 precursor Size: 2169 amino acids; 231518 Da
Subunit: A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 betachain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2and ERBB3 (By similarity)
Subcellular location: Membrane; Single-pass membrane protein (Potential). Secreted. Note=Isoforms lacking the Cys-richregion, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing
Subcellular location: Mucin-4 beta chain: Cell membrane; Single-pass membrane protein
Subcellular location: Mucin-4 alpha chain: Secreted
Subcellular location: Isoform 3: Cell membrane; Single-pass membrane protein
Subcellular location: Isoform 11: Secreted
Subcellular location: Isoform 15: Secreted
Subcellular location: Isoform 17: Cell membrane; Single-pass membrane protein
Developmental stage: Expressed early in the primitive gut before respiratory and digestive epithelial cells haveacquired their tissue and cell specificity. Expressed at the basal surface of the epithelium from week 14 to 26 weeksand then predominantly localized in only parietal cells. Immediately before birth, found in the cytoplasm of themucous columnar epithelial cells. In the embryo expressed in skin, then disappears late in gestation
Miscellaneous: Expression is a very useful predictor of poor prognosis in patients with invasive ductal carcinoma andintrahepatic cholangiocarcinoma, mass forming type (IDC,ICC-MF). Patients with IDC or ICC-MF who have high MUC4expression had a worse survival rate than those with low MUC4 expression
Sequence caution: Sequence=AAA63230.1; Type=Miscellaneous discrepancy; Note=May be derived from an intron translation;Sequence=CAC14139.1; Type=Frameshift; Positions=1171; Sequence=CAC14141.1; Type=Frameshift; Positions=1256;
Secondary accessions: O95938 Q9GZM2 Q9GZV6 Q9H481 Q9H482 Q9H483 Q9H484 Q9H485 Q9H486 Q9H487 Q9H4D6Q9H4D8 Q9NPJ0 Q9NY09 Q9NY75 Q9NY76 Q9NY77 Q9NY78 Q9NY79 Q9NY80 Q9NY81Alternative splicing: 14 isoforms: Q99102-1 Q99102-2 Q99102-3 Q99102-5 Q99102-7 Q99102-8 Q99102-9 Q99102-10 Q99102-11 Q99102-12 Q99102-13 Q99102-15 Q99102-16 Q99102-17 (Dubious isoform produced through aberrant splice sites)Explore the universe of human proteins at neXtProt for MUC4: NX_Q99102
Post-translational modifications:
Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain1
mucrnin-4 alpha chain is highly O-glycosylated1
mucin-4 beta chain is predominantly N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99102
MUC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_004523.3 NP_060876.5 NP_612154.2
ENSEMBL proteins: ENSP00000310528 ENSP00000389780 ENSP00000345378 ENSP00000407750 ENSP00000376208 ENSP00000338109 ENSP00000304207 ENSP00000419798 ENSP00000417498 ENSP00000417757 ENSP00000417722 ENSP00000420243 ENSP00000419989 ENSP00000417657 ENSP00000420439 ENSP00000417397 ENSP00000418306 Reactome Protein details: Q99102
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MUC4 for ontologies About GeneDecksing
MUC4 Antibody Products:
Assay Products for MUC4: |
Protein
Domains /
Families
for MUC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MUC4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99102ProtoNet protein and cluster: Q99102 UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102Similarity: Contains 1 AMOP domainSimilarity: Contains 2 EGF-like domainsSimilarity: Contains 1 NIDO domainSimilarity: Contains 1 VWFD domain |
Function
for MUC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102Function: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression ofapoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through bothanti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as anintramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cellsby inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of theERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 fromacting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of aMUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulationof proliferation Genatlas biochemistry entry for MUC4:mucin 4,homolog of rat sialomucin,tracheobronchial,involved in intestinal epithelial cell differentiation,expressed inovarian epithelial cancer,decreasing with increased cancer stage,ligand for Erb2 in cell signaling
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MUC4 (NM_004532) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUC4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MUC4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MUC4:
|
Pathways & Interactions
for MUC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for MUC4 (see all 8)
MUC4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MUC4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/51 Interacting proteins for MUC4 (Q991023 ENSP000003042074) via UniProtKB, MINT, STRING, and/or I2D (see all 51)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
MUC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for MUC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MUC4 for compounds About GeneDecksing
 Browse Tocris compounds for MUC4
10/12 Novoseek chemical compound relationships for MUC4 gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoic acid |
32.7 |
28 |
10938282 (5), 16007204 (4), 14691162 (3), 11246122 (1) (see all 9) |
| tyrosine |
20.6 |
10 |
18381409 (1), 17126950 (1), 19293191 (1), 16857800 (1) (see all 7) |
| trastuzumab |
11.6 |
7 |
15695389 (2), 16683005 (1) |
| progesterone |
10.1 |
12 |
12823988 (4), 8554551 (1), 16807280 (1), 19899128 (1) |
| oligonucleotide |
9.59 |
1 |
8604237 (1) |
| phosphatidylinositol |
5.57 |
3 |
16690615 (1), 14583090 (1) |
| cholesterol |
5.26 |
4 |
12517055 (3) |
| calcium |
3.55 |
2 |
12517055 (2) |
| matrigel |
3.15 |
1 |
15672420 (1) |
| steroid |
0 |
3 |
16807280 (1), 17891050 (1) |
Search CenterWatch for drugs/clinical trials and news about MUC4
|
Transcripts
for MUC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MUC4 gene (5 alternative transcripts): NM_004532.5 NM_018406.6 NM_138297.4 NM_138298.1 NM_138299.1 Unigene Cluster for MUC4: Mucin 4, cell surface associated Hs.369646 [show with all ESTs]Unigene Representative Sequence: NM_01840618/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000308466(uc003fuz.3) ENST00000448861(uc003fvd.3) ENST00000339251
ENST00000415455 ENST00000392407 ENST00000349607 ENST00000346145 ENST00000478156(uc003fvc.3 uc010hzr.3 uc021xjh.1)
ENST00000463781(uc003fva.3 uc003fvb.3 uc003fve.3 uc021xjg.1 uc021xji.1 uc021xjj.1 uc021xjk.1 uc021xjl.1 uc021xjm.1 uc021xjn.1 uc021xjo.1 uc021xjp.1 uc003fvo.3 uc003fvp.3)
ENST00000479406 ENST00000466475 ENST00000475231 ENST00000477086 ENST00000480843
ENST00000470451 ENST00000462323 ENST00000477756 ENST00000464234(uc010hzq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MUC4 (NM_004532) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUC4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC4 |
Additional cDNA sequence: AF058803.1 AF058804.1 AF177925.1 AJ000281.1 AJ010901.1 AJ242541.1 AJ242542.1 AJ242543.1 AJ242544.1 AJ242545.1 AJ242546.1 AJ242547.1 AJ242548.1 AJ242549.1 AJ242550.1 AJ276359.1 AJ277412.1 AJ400858.1 AK074437.1 AK307054.1 BC131770.1 EF091824.1 M64594.1 24/42 DOTS entries (see all 42): DT.91758822 DT.100787919 DT.92445406 DT.92445399 DT.97803505 DT.405187 DT.92445416 DT.40274454 DT.91649767 DT.95093794 DT.92445402 DT.95107871 DT.92036627 DT.100787925 DT.92445418 DT.95121081 DT.95153962 DT.95278149 DT.100787922 DT.120927567 DT.120927650 DT.92445404 DT.95278152 DT.92445420 24/86 AceView cDNA sequences (see all 86): AF058804 AJ242545 AJ242541 NM_138297 AJ242544 AJ277505 NM_004532 AK074437 AJ242549 BF354478 AJ242543 AF058803 AK127293 AJ242550 BF370453 BF354487 AJ000281 AJ242542 BI014506 AI660643 BF354486 BF354489 BG955000 AW939469
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MUC4 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP5: | | | | | | | | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | |
| ExUns: | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | · | 25c | ^ | 26 | ^ | 27 |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | - | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | - | | | | | | | | - | | - | | | | | | |
| SP5: | | | | | - | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for MUC4
|
Expression
for MUC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MUC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MUC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MUC4
SOURCE GeneReport for Unigene cluster: Hs.369646
UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102Tissue specificity: Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon,testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from someof these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammarycarcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronicpancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines
SABiosciences Expression via Pathway-Focused PCR Array including MUC4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MUC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC4 |
Orthologs
for MUC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MUC4 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
Muc26B6 |
Mucin 26B |
11(a) |
1 ↔ 1 |
2L(6151971-6153701) |
worm
(Caenorhabditis elegans) |
Secernentea |
C26G2.26 |
Protein C26G2.2 |
7(a) |
1 ↔ 1 |
X(14664220-14671231) |
ENSEMBL Gene Tree for MUC4 (if available)
TreeFam Gene Tree for MUC4 (if available) |
Paralogs
for MUC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MUC4 gene
- SUSD22
1 SIMAP similar gene for MUC4 using alignment to 17 protein entries: MUC4_HUMAN (see all proteins):MUC12
MUC4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MUC4
PGOHUM00000243578
|
Genomic Variants
for MUC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MUC4 (195473636 - 195539148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 34 variations for MUC4
15/28 CNVs (see all 28): 32549 68550 7399 2491 3472 68544 6229 4366 2064 68548 80087 59127 8439 80084 91823
4 Indels: 46372 46371 63711 41761
2 Inversions: 37243 0568
Human Gene Mutation Database (HGMD): MUC4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC4 |
|
Disorders
/ Diseases
for MUC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MUC4 for disorders About GeneDecksing
OMIM gene information: 158372
OMIM disorders: --
20/53  diseases for MUC4 (see all 53): About MalaCardsdry eye syndrome adenocarcinoma pancreatitis otitis media
non-small cell lung carcinoma biliary tract cancer ethmoid sinusitis bile duct carcinoma
carcinoma cystic fibrosis inflammatory bowel disease papillary thyroid carcinoma
papillary carcinoma intrahepatic cholangiocarcinoma mucoepidermoid carcinoma endometrial carcinoma
lung carcinoma bronchiolitis squamous cell carcinoma esophageal carcinoma
3 diseases from the University of Copenhagen DISEASES database for MUC4:Pancreatic cancer Carcinoma Cystic fibrosis 10/53 Novoseek disease relationships for MUC4 gene (see all 53) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenocarcinoma |
62.4 |
58 |
17425390 (4), 12657964 (3), 11751498 (3), 16880135 (3) (see all 27) |
| pancreatic cancer |
58.8 |
57 |
16274046 (7), 20423995 (6), 15461591 (4), 17595659 (4) (see all 17) |
| metaplasia |
56.3 |
11 |
17090193 (2), 10738241 (2), 11093805 (1), 19946103 (1) (see all 6) |
| pancreatic tumor |
53.1 |
19 |
17032197 (4), 8157358 (3), 10920259 (2), 10938282 (2) (see all 7) |
| biliary tract cancer |
46 |
1 |
18475301 (1) |
| epithelial tumor |
42 |
1 |
18492726 (1) |
| chronic pancreatitis |
41.3 |
9 |
11751498 (3), 16274046 (2), 17425384 (2), 14760381 (1) |
| dry eye syndromes |
40.7 |
1 |
15678360 (1) |
| pancreatic carcinoma |
40.3 |
1 |
10938282 (1) |
| carcinoma |
40.1 |
20 |
19127263 (2), 11596032 (2), 17595659 (1), 16857800 (1) (see all 11) |
Genetic Association Database (GAD): MUC4
Human Genome Epidemiology (HuGE) Navigator: MUC4 (7 documents)
Export disorders for MUC4 gene to outside databases
|
Publications
for MUC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MUC4 gene, integrated from 9 sources (see all 280):
(articles sorted by number of sources associating them with MUC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. (PubMed id 1673336)1, 2, 3 Porchet N.... Aubert J.-P. (1991)
- MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. (PubMed id 16049287)1, 2, 9 Saitou M.... Yonezawa S. (2005)
- MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC). (PubMed id 16814944)1, 2, 9 Karg A.... Ucvet A. (2006)
- MUC4 expression and localization in gastrointestinal tract and skin of human embryos. (PubMed id 16914178)1, 2, 9 Zhang J.... Carraway K.L. (2006)
- Human MUC4 mucin cDNA and its variants in pancreatic carcinoma. (PubMed id 10920259)1, 2, 9 Choudhury A.... Batra S.K. (2000)
- Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins. (PubMed id 10880978)1, 2, 9 Moniaux N....Aubert J.-P. (2000)
- Complete sequence of the human mucin MUC4: a putative cell membrane- associated mucin. (PubMed id 10024507)1, 2, 9 Moniaux N.... Aubert J.-P. (1999)
- Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. (PubMed id 12102554)1, 2 Carraway K.L.... Carraway C.A. (2002)
- Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4. (PubMed id 12084055)1, 2 Desseyn J.-L.... Laine A. (2002)
- Genomic organization of MUC4 mucin gene: towards the characterization of splice variants. (PubMed id 12153560)1, 2 Escande F....Buisine M.P. (2002)
|
External Searches for MUC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing MUC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing MUC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for MUC4 gene:
Search GeneIP for patents involving MUC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MUC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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 | |
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