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MUC4 Gene

protein-coding   GIFtS: 62

GC03M196963
mucin 4, cell surface associated
(Previous names: mucin 4, tracheobronchial )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for MUC4

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ASGP 3
HSA276359 2
MUC-4 3
Descriptions
Ascites sialoglycoprotein 3
Pancreatic adenocarcinoma mucin 3
Testis mucin 3
Tracheobronchial mucin 3
mucin 4 2
mucin 4, cell surface associated 2
mucin 4, tracheobronchial 1, 2
External Ids
HGNC: 75141
Entrez Gene: 45852
UniProtKB: Q991023
Ensembl: ENSG000001451137
Search outside databases for aliases for MUC4 gene

Previous GC identifers: GC03P191251 GC03P195544 GC03M196882 GC03M196801

Summaries
for MUC4

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for MUC4:
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as
those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These
glycoproteins play important roles in the protection of the epithelial cells and have been
implicated in epithelial renewal and differentiation. This gene encodes an integral membrane
glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen
transcript variants of this gene have been found, although for many of them the full-length
transcript has not been determined or they are found only in tumor tissues. This gene contains a
region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
[provided by RefSeq]

UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102
Function: May play a role in tumor progression. Ability to promote tumor growth may be mainly due
to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to
alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular
matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an
important role in cell proliferation and differentiation of epithelial cells by inducing specific
phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2
'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents
ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of
CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B,
resulting in repression of apoptosis and stimulation of proliferation

Gene Wiki entry for MUC4

Genomic Location
for MUC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MUC4 gene  

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

MUC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M196963:     (about GC identifiers)

Start:
 196,959,307 bp from pter
End:
 197,023,545 bp from pter
Size:
 64,239 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000003.10  NT_029928.12  

Proteins
for MUC4

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102 (See protein sequence)
Recommended Name: Mucin-4 precursor  
Size: 2169 amino acids; 231584 Da
Subunit: A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich
transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain
1. In nonpolarized cells, associates with ERBB2 and ERBB3 (By similarity)
Subcellular location: Membrane; Single-pass membrane protein (Potential). Secreted. Note=Isoforms
lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion
occurs by splicing or proteolytic processing
Developmental stage: Expressed early in the primitive gut before respiratory and digestive
epithelial cells have acquired their tissue and cell specificity. Expressed at the basal surface
of the epithelium from week 14 to 26 weeks and then predominantly localized in only parietal
cells. Immediately before birth, found in the cytoplasm of the mucous columnar epithelial cells.
In the embryo expressed in skin, then disappears late in gestation
Miscellaneous: Expression is a very useful predictor of poor prognosis in patients with invasive
ductal carcinoma and intrahepatic cholangiocarcinoma, mass forming type (IDC,ICC-MF). Patients
with IDC or ICC-MF who have high MUC4 expression had a worse survival rate than those with low
MUC4 expression
Sequence caution: Sequence=AAA63230.1; Type=Miscellaneous discrepancy; Note=May be derived from an
intron translation; Sequence=CAC14139.1; Type=Frameshift; Positions=1171; Sequence=CAC14141.1;
Type=Frameshift; Positions=1256;
Secondary accessions: O95938 Q9GZM2 Q9GZV6 Q9H481 Q9H482 Q9H483 Q9H484 Q9H485 Q9H486 Q9H487 Q9H4D6
Q9H4D8 Q9NPJ0 Q9NY09 Q9NY75 Q9NY76 Q9NY77 Q9NY78 Q9NY79 Q9NY80 Q9NY81
Alternative splicing: 14 isoforms:  Q99102-1   Q99102-2   Q99102-3   Q99102-5   Q99102-7   Q99102-8   Q99102-9   Q99102-10   
Q99102-11   Q99102-12   Q99102-13   Q99102-15   Q99102-16   Q99102-17   (Additional isoforms exist)

Post-translational modifications:

  • Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain1
  • mucin-4 alpha chain is highly O-glycosylated1
  • mucin-4 beta chain is predominantly N-glycosylated1


    • REFSEQ proteins (3 alternative transcripts): 
    NP_004523.3  NP_060876.4  NP_612154.2  


    ENSEMBL proteins: 
    ENSP00000304207 ENSP00000338109 ENSP00000385849 ENSP00000310528 ENSP00000376209 ENSP00000376208 
    ENSP00000345378 ENSP00000329636 ENSP00000371356 ENSP00000371351 ENSP00000371350 ENSP00000371349 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (pan Mucin, MUC4)
    Human Recombinant Proteins from Abnova (MUC4)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix NAS10920259
    GO:0005730 nucleolus IDA18029348
    GO:0005887 integral to plasma membrane TAS10024507
    GO:0016020 membrane NAS10920259
    About this table

    Antibodies for MUC4: 
    Invitrogen Antibodies for MUC4
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MUC4
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (pan Mucin, MUC4), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (MUC4)
    Novus Biologicals Antibodies for MUC4

    Assays for MUC4: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for MUC4

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR003886 NIDO
     IPR005533 AMOP
     IPR000742 EGF_3
     IPR013032 EGF-like_reg_CS
     IPR006210 EGF-like


       GeneDecks  MUC4 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q99102

    ProtoNet protein and cluster: Q99102

    UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102
    Similarity: Contains 1 AMOP domain
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 NIDO domain
    Similarity: Contains 1 VWFD domain

    Gene Function
    for MUC4

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (MUC4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MUC4)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_018406

                  Applied Biosystems Silencer® siRNAs for MUC4

                  Sigma-Aldrich siRNA and siRNA Panels for MUC4  
                         Sigma-Aldrich shRNA Panels and shRNA for MUC4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004532
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004532
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_004532 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018406

    UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102
    Function: May play a role in tumor progression. Ability to promote tumor growth may be mainly due
    to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to
    alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular
    matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an
    important role in cell proliferation and differentiation of epithelial cells by inducing specific
    phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2
    'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents
    ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of
    CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B,
    resulting in repression of apoptosis and stimulation of proliferation

    Genatlas biochemistry entry for MUC4:
    mucin 4,homolog of rat sialomucin,tracheobronchial,involved in intestinal epithelial cell
    differentiation,expressed in ovarian epithelial cancer,decreasing with increased cancer
    stage,ligand for Erb2 in cell signaling

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005176 ErbB-2 class receptor binding TAS10024507
    GO:0005515 protein binding IEA--
    GO:0030197 extracellular matrix constituent, lubricant activity NAS10920259
    About this table

    Pathways & Interactions
    for MUC4

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MUC4 


    5/16 Interacting proteins for MUC4 (ENSP000003105283) via UniProtKB, MINT, and/or STRING (see all 16 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2ENSP000002695713STRING (score=.981)
    MUC20ENSP000003254313STRING (score=.907)
    IL6ENSP000002587433STRING (score=.885)
    CFTRENSP000000030843STRING (score=.866)
    IL9ENSP000002745203STRING (score=.853)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155 cell adhesion IEA--
    GO:0007160 cell-matrix adhesion IEA--
    GO:0008150 biological_process ND--
    About this table

    Drugs & Compounds
    for MUC4

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MUC4
    8 Novoseek chemical compound relationships for MUC4 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 22.76 10 18381409 (1), 17126950 (1), 19293191 (1), 16857800 (1) (see all 7)
    oligonucleotide 11.50 1 8604237 (1)
    phosphatidylinositol 7.70 3 16690615 (1), 14583090 (1)
    progesterone 6.84 10 12823988 (4), 8554551 (1), 16807280 (1)
    matrigel 5.90 1 15672420 (1)
    calcium 3.73 2 12517055 (2)
    cholesterol 0.00 4 12517055 (3)
    steroid 0.00 3 16807280 (1), 17891050 (1)
    About this table


    Transcripts
    for MUC4

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (MUC4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MUC4)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_018406

                  Sigma-Aldrich siRNA and siRNA Panels for MUC4  
                         Sigma-Aldrich shRNA Panels and shRNA for MUC4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004532  NM_018406  NM_138297  

    REFSEQ mRNAs for MUC4 gene (3 alternative transcripts): 

    NM_004532.4   NM_018406.4   NM_138297.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004532  NM_018406  NM_138297  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004532
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004532
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_004532 

    Additional cDNA sequence: 

    AF058803.1 AF058804.1 AF177925.1 AJ000281.1 AJ010901.1 AJ242541.1 AJ242542.1 AJ242543.1 
    AJ242544.1 AJ242545.1 AJ242546.1 AJ242547.1 AJ242548.1 AJ242549.1 AJ242550.1 AJ276359.1 
    AJ277412.1 AJ400858.1 AK074437.1 AK307054.1 BC131770.1 EF091824.1 M64594.1 

    24/42 DOTS entries (see all 42 ):

    DT.91758822  DT.100787919  DT.92445406  DT.97803505  DT.92445399  DT.405187  DT.92445416  DT.40274454 
    DT.91649767  DT.95093794  DT.92445402  DT.92036627  DT.95107871  DT.100787925  DT.92445418  DT.95121081 
    DT.95153962  DT.95278149  DT.100787922  DT.120927567  DT.120927650  DT.92445404  DT.95278152  DT.92445420 

    24/86 AceView cDNA sequences (see all 86 ):

    AF058804 AK074437 NM_004532 AJ000281 AJ242543 AK127293 AJ242545 AJ242544 
    BF370453 AJ277505 BF354478 AF058803 NM_138297 AJ242550 AJ242542 BF354487 
    AJ242541 AJ242549 BF354481 AW515653 BG955000 BF354486 BF354489 AW594131 

    highest scoring ESTs for MUC4:

    AJ010901 BF370369 AJ000281 AJ242549 AJ242550 AJ276359 AJ277412 AJ400858 AA807586 AF058803 

    Unigene Cluster for MUC4:

    Mucin 4, cell surface associated
    Hs.369646  [show with all ESTs]
    Unigene Representative Sequence: NM_018406


    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MUC4 (see all 13 )

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:              -           -                       -           -                                                                                             
    SP2:              -     -     -                       -           -                                                                                             
    SP3:                          -           -           -           -           -                                                                                 
    SP4:                                                              -                                                                                         -   
    SP5:                          -                       -           -                                                                                         -   

    ExUns: 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27
    SP1:              -                       -     -               
    SP2:              -                       -     -               
    SP3:              -                       -     -               
    SP4:              -                       -     -               
    SP5:              -                       -     -               

    About this scheme

    ECgene alternative splicing isoforms for MUC4

    12 Ensembl transcripts including schematic representations:
    ENST00000346145  ENST00000349607  ENST00000405167  ENST00000308466  ENST00000392409  ENST00000392407  
    ENST00000339251  ENST00000333177  ENST00000381931  ENST00000381926  ENST00000381925  ENST00000381924  

    Expression
    for MUC4

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MUC4 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MUC4

    1 / 2 / 3

    9 probe-sets matching MUC4 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		734_at2, 3 U95-A 1 1.00 1.00 0.51 1.14 HG2157-HT2227 0.20 0.50 0.38 1
    35912_at2, 3 U95-A 1 1.00 1.00 0.94 0.87 AJ010901 0.80 1.00 0.91 1

    		204895_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004532 0.60 1.00 0.82 1

    		217109_at2, 3 U133-A 1 1.00 1.00 -- -- AJ242547 0.60 1.00 0.82 1

    		217110_s_at2, 3 U133-A 1 1.00 1.00 -- -- AJ242547 0.60 1.00 0.82 1

    		204895_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		217109_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		217110_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1561785_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  MUC4 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.369646

    Expression variation in blood from EXPOLDB for MUC4

    UniProtKB/Swiss-Prot: MUC4_HUMAN, Q99102
    Tissue specificity: Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small
    intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands.
    Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell
    carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix
    cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly
    expressed in pancreatic tumors and pancreatic tumor cell lines

    Orthologs
    for MUC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for MUC4 gene from 4 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 MUC41   -- mucin 4, cell surface associated 88.66(n)
    84.62(a)    		 750124  XM_001173152.1  XP_001173152.1 
    rat
    (Rattus norvegicus)    		 Muc41   -- mucin 4, cell surface associated 61.75(n)
    49.93(a)    		 303887  XM_221384.4  XP_221384.4 
    mouse
    (Mus musculus)    		 Muc41, 5 165
    		 mucin 41, 5 62.76(n)1
    51.01(a)1    		 1404741  NM_080457.21  NP_536705.21 
     AF1612565  AF2182655  (see all 17)
    chicken
    (Gallus gallus)    		 MUC41   -- mucin 4, cell surface associated 54.6(n)
    42.41(a)    		 429149  XM_426704.2  XP_426704.2 
    About this table        Species with no ortholog for MUC4

    ENSEMBL Gene Tree for MUC4

    Paralogs
    for MUC4

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MUC4 gene
    ENSG000002146392  MUC162  RBMXL32  MUC172  TPRXL2  MUC122  

    Pseudogenes
    2 related pseudogenes


    SNPs/Variants
    for MUC4

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/841 NCBI SNPs in MUC4 are shown (see all 841 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 115)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs26885331,2
    		A,C,F,H197025355(+) AAACCC/TGGGCT 3 -- ng314Minor allele frequency- T:0.18EU EA WA 418
    rs22932321,2
    		A,C,F,H196982777(+) TAGGGC/TCCACC 3 A/T mis1 ese35Minor allele frequency- T:0.19EA EU WA 1916
    rs31077641,2
    		A,C,F,H197002725(-) AAACTC/GCTGCC 3 A/P mis1 int1 ese312Minor allele frequency- N:0.00EU EA WA NA 1054
    rs21132261,2
    		A,C,F,H196959160(+) GTAACC/GGGGCT 3 -- ng511Minor allele frequency- G:0.27WA 116
    --
    rs7120051,2
    		A,C,F,H196959312(+) TTTTGA/GAGACA 3 -- ut31 ese39Minor allele frequency- G:0.15MN EU EA WA 1014
    rs22592921,2
    		A,C,F,H196986783(+) CGGCGT/CCTGCC 3 D/G mis12Minor allele frequency- C:0.29EA WA 1612
    rs21773361,2
    		A,C,F,H197001273(+) AGCTGC/TCCCTG 3 T/A mis1 int1 ese313Minor allele frequency- T:0.19EU EA WA NA 1986
    rs22591021,2
    		A,C,F,H196982808(+) TTTGTG/CATCTT 3 I/M mis19Minor allele frequency- C:0.17EA EU WA 2272
    rs7295931,2
    		A,C,F,H197002304(-) ACGAAC/AAACTT 3 K/T mis1 int112Minor allele frequency- A:0.05MN EU EA WA NA 1158
    rs8826051,2
    		A,C,F,H197001948(-) TAACAG/TTTGAT 3 F/V mis1 int113Minor allele frequency- T:0.21MN EU EA WA NA 1232
    About this table

    HapMap Linkage Disequilibrium images for MUC4 (up to first 250kb)

    Disorders & Mutations
    for MUC4

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 158372

    10/50 Novoseek disease relationships for MUC4 gene (see all 50 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 60.98 55 17425390 (4), 12657964 (3), 11751498 (3), 16880135 (3) (see all 26)
    pancreatic cancer 58.65 49 16274046 (7), 15461591 (4), 17595659 (4), 17525742 (3) (see all 16)
    pancreatic tumor 55.00 19 17032197 (4), 8157358 (3), 10920259 (2), 10938282 (2) (see all 7)
    metaplasia 52.79 10 17090193 (2), 10738241 (2), 11093805 (1), 11831115 (1) (see all 5)
    biliary tract cancer 48.52 1 18475301 (1)
    epithelial tumor 43.97 1 18492726 (1)
    chronic pancreatitis 43.12 9 11751498 (3), 16274046 (2), 17425384 (2), 14760381 (1)
    dry eye syndromes 42.80 1 15678360 (1)
    pancreatic carcinoma 42.10 1 10938282 (1)
    carcinoma mucinous 41.82 1 12210083 (1)
    About this table

    1 PharmGKB disease relationship for MUC4 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
    About this table

    Human Gene Mutation Database: MUC4
    Genetic Association Database: MUC4
    Human Genome Epidemiology Navigator: MUC4 (4 documents)

    Medical News
    for MUC4

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for MUC4

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/234 PubMed articles for MUC4 gene (see all 234 ):

    Search for MUC4

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MUC4

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 4585 HGNC: 7514 AceView: MUC4 Ensembl:ENSG00000145113 euGenes: HUgn4585
    ECgene: MUC4 H-InvDB: MUC4

    Other Databases showing MUC4

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing MUC4

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for MUC4 Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    Licensable Technologies
    for MUC4

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for MUC4

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MUC4:
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