MUC3B Gene
protein-coding GIFtS : 33
GCID: GC07 U903146 (predicted)
mucin 3B, cell surface associated (Previous name: mucin 3B )
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Aliasesfor MUC3B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Mucin 3B, Cell Surface Associated 1 2 MUC32 Intestinal Mucin-3B2 3 MUC3A2 MUC-3B2 3 Intestinal Mucin MUC3B2 Mucin 3B1 Mucin-3B1
Export aliases for MUC3B gene to outside databases Previous GC identifers: GC07P099084 GC07P100147 GC07P100160 GC07P100158 GC07P100191 GC07P100332 GC07P100547
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Summariesfor MUC3B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195 Function : Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrieragainst particles and infectious agents at mucosal surfaces (By similarity)
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Genomic Viewsfor MUC3B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for MUC3B Other transcription factors Search SABiosciences Chromatin IP Primers for MUC3B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC3B
Genomic Location: Chromosome: 7 Entrez Gene cytogenetic band: 7q22 HGNC cytogenetic band: 7q22 GeneLoc information about chromosome 7
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Proteinsfor MUC3B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195 (See
protein sequence )Recommended Name: Mucin-3B Size : 901 amino acids; 96193 Da
Subcellular location : Membrane; Single-pass membrane protein (Potential)
Secondary accessions : Q7LDU5 Q9GZZ2 Q9UN95Explore the universe of human proteins at neXtProt for MUC3B: NX_Q9H195 Post-translational modifications:
Highly O-glycosylated and probably also N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H195 MUC3B Protein expression data from MOPED and PaxDb : --Reactome Protein details: Q9H195 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005796 Golgi lumen
TAS -- GO:0016021 integral to membrane
IEA --
MUC3B for ontologies About GeneDecksing MUC3B Antibody Products: Assay Products for MUC3B:
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Protein
Domains / Familiesfor MUC3B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MUC3B for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9H195 ProtoNet protein and cluster: Q9H195
1 Blocks protein family : IPB000082 SEA domain UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195 Similarity : Contains 1 EGF-like domainSimilarity : Contains 1 SEA domain
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Functionfor MUC3B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195 Function : Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrieragainst particles and infectious agents at mucosal surfaces (By similarity)
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC3B
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Pathways & Interactionsfor MUC3B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein 2 Asparagine N-linked glycosylation
Pathway sources See GeneCards unified pathways Show all pathways 5/8
Reactome Pathways for MUC3B (see all 8 )
MUC3B for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUC3B Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016266 O-glycan processing
TAS -- GO:0043687 post-translational protein modification
TAS -- GO:0044267 cellular protein metabolic process
TAS --
MUC3B for ontologies About GeneDecksing
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Drugs & Compoundsfor MUC3B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
MUC3B for compounds About GeneDecksing Browse Tocris compounds for MUC3B 3 Novoseek chemical compound relationships for MUC3B gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
threonine
55.7
1
7864366 (1)
oligonucleotide
8.49
1
2254452 (1)
tyrosine
3.06
1
11289722 (1)
Search CenterWatch for drugs/clinical trials and news about MUC3B
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Transcriptsfor MUC3B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section 3 AceView cDNA sequences :
BI005786 BF844624 AY307931
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Expression for MUC3B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MUC3B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image MUC3B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Genevestigator expression for MUC3B UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195 Tissue specificity : Fetal and adult small intestine and fetal and adult colon SABiosciences Custom PCR Arrays for MUC3B Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat MUC3B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MUC3B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MUC3B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC3B
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Orthologsfor MUC3B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
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Paralogsfor MUC3B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor MUC3B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor MUC3B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MUC3B for disorders About GeneDecksing
OMIM gene information: 605633
OMIM disorders : --10 diseases for MUC3B : About MalaCards barrett's esophagus cystic fibrosis ulcerative colitis colon cancer fibrosis crohn's disease colon adenocarcinoma adenocarcinoma gastric cancer colorectal cancer 4 Novoseek disease relationships for MUC3B gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
barrett esophagus
50.4
8
16803684 (8)
colon cancer
49.7
4
8110187 (2), 12198708 (1), 1728605 (1)
cystic fibrosis
13.2
2
2254452 (1), 8500875 (1)
adenocarcinoma
12.5
1
1550588 (1)
Export disorders for MUC3B gene to outside databases
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Publicationsfor MUC3B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MUC3B gene, integrated from 9 sources (see all 39 ): (articles sorted by number of sources associating them with MUC3B) Utopia : connect your pdf to the dynamic world of online information
Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. (PubMed id 10973822) 1 , 2 , 3, 9 Pratt W.S....Swallow D.M. (2000) Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. (PubMed id 11289722) 1 , 2 , 9 Kyo K.... Nakamura Y. (2001) The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. (PubMed id 10405327) 1 , 2 Williams S.J.... McGuckin M.A. (1999) MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region. (PubMed id 9334251) 1 , 2 Gum J.R. Jr.... Kim Y.S. (1997) Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus. (PubMed id 12958310) 1 , 9 Gum J.R. Jr.... Kim Y.S. (2003) Expression of mucin 3 and mucin 5AC in arthritic synovial tissue. (PubMed id 18163520) 1 Volin M.V....Koch A.E. (2008) The DNA sequence of human chromosome 7. (PubMed id 12853948) 1 Hillier L.W.... Wilson R.K. (2003) Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin. (PubMed id 10512748) 1 Crawley S.C.... Kim Y.S. (1999) Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. (PubMed id 2393399) 1 Gum J.R. Jr.... Kim Y.S. (1990) Prevalence of and risk factors for Barrett's esophagu s with intestinal predominant mucin phenotype. (PubMed id 16803684) 9 Amano Y....Kinoshita Y. (2006)
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External Searches for MUC3B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MUC3B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MUC3B gene
(According to HUGE )
About This Section --
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Specialized Databases showing MUC3B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MUC3B Pharmacogenomics, SNPs, Pathways Mucin database http://www.medkem.gu.se/mucinbiology/databases/
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About This Section Patent Information for MUC3B gene: Search GeneIP for patents involving MUC3B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MUC3B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUC3B Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC3B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC3B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MUC3B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MUC3B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MUC3B
Search Tocris compounds for MUC3B
MUC3B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC3B
Search ThermoFisher Antibodies for MUC3B
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC3B
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Function for MUC3B
Genomic Views for MUC3B
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