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Aliases for MUC3B Gene

Aliases for MUC3B Gene

  • Mucin 3B, Cell Surface Associated 2 3
  • Intestinal Mucin-3B 3 4
  • MUC-3B 3 4
  • Intestinal Mucin MUC3B 3
  • Mucin 3B 2
  • Mucin-3B 3
  • MUC3A 3
  • MUC3 3

External Ids for MUC3B Gene

Previous GeneCards Identifiers for MUC3B Gene

  • GC07P099084
  • GC07P100147
  • GC07P100160
  • GC07P100158
  • GC07P100191
  • GC07P100332
  • GC07P100547
  • GC07Pg99965
  • GC07Pg99966

Summaries for MUC3B Gene

GeneCards Summary for MUC3B Gene

MUC3B (Mucin 3B, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC3B include ulcerative colitis and cystic fibrosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

UniProtKB/Swiss-Prot for MUC3B Gene

  • Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC3B Gene

Genomics for MUC3B Gene

Genomic Location for MUC3B Gene

Orientation:
Unknown strand

Genomic View for MUC3B Gene

Cytogenetic band:

RefSeq DNA sequence for MUC3B Gene

No data available for Regulatory Elements for MUC3B Gene

Proteins for MUC3B Gene

  • Protein details for MUC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H195-MUC3B_HUMAN
    Recommended name:
    Mucin-3B
    Protein Accession:
    Q9H195
    Secondary Accessions:
    • Q6W762
    • Q7LDU5
    • Q9GZZ2
    • Q9UN95

    Protein attributes for MUC3B Gene

    Size:
    1237 amino acids
    Molecular mass:
    131402 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MUC3B Gene

Proteomics data for MUC3B Gene at MOPED

Post-translational modifications for MUC3B Gene

Other Protein References for MUC3B Gene

Reactome Protein details:

No data available for DME Specific Peptides for MUC3B Gene

Domains for MUC3B Gene

Gene Families for MUC3B Gene

HGNC:

Protein Domains for MUC3B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H195

UniProtKB/Swiss-Prot:

MUC3B_HUMAN :
  • Q9H195
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 SEA domain.
genes like me logo Genes that share domains with MUC3B: view

Function for MUC3B Gene

Molecular function for MUC3B Gene

UniProtKB/Swiss-Prot Function: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MUC3B Gene

Localization for MUC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC3B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC3B Gene COMPARTMENTS Subcellular localization image for MUC3B gene
Compartment Confidence
extracellular 3
cytosol 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MUC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MUC3B: view

Pathways for MUC3B Gene

genes like me logo Genes that share pathways with MUC3B: view

Interacting Proteins for MUC3B Gene

Gene Ontology (GO) - Biological Process for MUC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC3B: view

Compounds for MUC3B Gene

(3) Novoseek inferred chemical compound relationships for MUC3B Gene

Compound -log(P) Hits PubMed IDs
threonine 55.7 1
oligonucleotide 8.49 1
tyrosine 3.06 1
genes like me logo Genes that share compounds with MUC3B: view

Transcripts for MUC3B Gene

mRNA/cDNA for MUC3B Gene

(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MUC3B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC3B Gene

No ASD Table

Relevant External Links for MUC3B Gene

ECgene alternative splicing isoforms for
MUC3B

Expression for MUC3B Gene

mRNA expression in normal human tissues for MUC3B Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MUC3B Gene

mRNA Expression by UniProt/SwissProt for MUC3B Gene

Q9H195-MUC3B_HUMAN
Tissue specificity: Fetal and adult small intestine and fetal and adult colon.
genes like me logo Genes that share expressions with MUC3B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MUC3B Gene

Orthologs for MUC3B Gene

No data available for Orthologs and Evolution for MUC3B Gene

Paralogs for MUC3B Gene

Selected SIMAP similar genes for MUC3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MUC3B: view

No data available for Paralogs for MUC3B Gene

Variants for MUC3B Gene

Sequence variations from dbSNP and Humsavar for MUC3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_029507 -
VAR_029508 -

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MUC3B Gene

Disorders for MUC3B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MUC3B Gene including...

Search for MUC3B Gene in MalaCards »

(4) Novoseek inferred disease relationships for MUC3B Gene

Disease -log(P) Hits PubMed IDs
barrett esophagus 50.4 8
colon cancer 49.7 4
cystic fibrosis 13.2 2
adenocarcinoma 12.5 1
genes like me logo Genes that share disorders with MUC3B: view

No data available for UniProtKB/Swiss-Prot for MUC3B Gene

Publications for MUC3B Gene

  1. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. (PMID: 10973822) Pratt W.S. … Swallow D.M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. (PMID: 11289722) Kyo K. … Nakamura Y. (J. Hum. Genet. 2001) 3 4 23
  3. Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus. (PMID: 12958310) Gum J.R. Jr. … Kim Y.S. (J. Biol. Chem. 2003) 3 4 23
  4. MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region. (PMID: 9334251) Gum J.R. Jr. … Kim Y.S. (J. Biol. Chem. 1997) 3 4
  5. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. (PMID: 10405327) Williams S.J. … McGuckin M.A. (Biochem. Biophys. Res. Commun. 1999) 3 4

Products for MUC3B Gene

Sources for MUC3B Gene

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