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Aliases for MUC3B Gene

Aliases for MUC3B Gene

  • Mucin 3B, Cell Surface Associated 2 3
  • Intestinal Mucin-3B 3 4
  • MUC-3B 3 4
  • Intestinal Mucin MUC3B 3
  • Mucin 3B 2
  • MUC3A 3
  • MUC3 3

External Ids for MUC3B Gene

Previous GeneCards Identifiers for MUC3B Gene

  • GC07P099084
  • GC07P100147
  • GC07P100160
  • GC07P100158
  • GC07P100191
  • GC07P100332
  • GC07P100547
  • GC07Pg99965
  • GC07Pg99966

Summaries for MUC3B Gene

GeneCards Summary for MUC3B Gene

MUC3B (Mucin 3B, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC3B include barrett esophagus/esophageal adenocarcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and O-linked glycosylation.

UniProtKB/Swiss-Prot for MUC3B Gene

  • Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC3B Gene

Genomics for MUC3B Gene

Genomic Location for MUC3B Gene

Chromosome:
7
Orientation:
Unknown strand

Genomic View for MUC3B Gene

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MUC3B Gene

No data available for Regulatory Elements for MUC3B Gene

Proteins for MUC3B Gene

  • Protein details for MUC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H195-MUC3B_HUMAN
    Recommended name:
    Mucin-3B
    Protein Accession:
    Q9H195
    Secondary Accessions:
    • Q6W762
    • Q7LDU5
    • Q9GZZ2
    • Q9UN95

    Protein attributes for MUC3B Gene

    Size:
    1237 amino acids
    Molecular mass:
    131402 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MUC3B Gene

Proteomics data for MUC3B Gene at MOPED

Post-translational modifications for MUC3B Gene

No data available for DME Specific Peptides for MUC3B Gene

Domains & Families for MUC3B Gene

Gene Families for MUC3B Gene

HGNC:

Protein Domains for MUC3B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H195

UniProtKB/Swiss-Prot:

MUC3B_HUMAN :
  • Contains 1 EGF-like domain.
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 SEA domain.
genes like me logo Genes that share domains with MUC3B: view

Function for MUC3B Gene

Molecular function for MUC3B Gene

UniProtKB/Swiss-Prot Function:
Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).

Phenotypes for MUC3B Gene

GenomeRNAi human phenotypes for MUC3B:
genes like me logo Genes that share phenotypes with MUC3B: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUC3B Gene

Localization for MUC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC3B Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MUC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MUC3B: view

No data available for Subcellular locations from COMPARTMENTS for MUC3B Gene

Pathways & Interactions for MUC3B Gene

genes like me logo Genes that share pathways with MUC3B: view

Interacting Proteins for MUC3B Gene

Gene Ontology (GO) - Biological Process for MUC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC3B: view

No data available for SIGNOR curated interactions for MUC3B Gene

Drugs & Compounds for MUC3B Gene

(2) Drugs for MUC3B Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
threonine Nutra 16
tyrosine Nutra 547

(1) Additional Compounds for MUC3B Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oligonucleotide
genes like me logo Genes that share compounds with MUC3B: view

Transcripts for MUC3B Gene

mRNA/cDNA for MUC3B Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC3B Gene

No ASD Table

Relevant External Links for MUC3B Gene

ECgene alternative splicing isoforms for
MUC3B

Expression for MUC3B Gene

mRNA expression in normal human tissues for MUC3B Gene

Protein differential expression in normal tissues from HIPED for MUC3B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUC3B Gene



mRNA Expression by UniProt/SwissProt for MUC3B Gene

Q9H195-MUC3B_HUMAN
Tissue specificity: Fetal and adult small intestine and fetal and adult colon.
genes like me logo Genes that share expression patterns with MUC3B: view

Protein tissue co-expression partners for MUC3B Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MUC3B Gene

Orthologs for MUC3B Gene

No data available for Orthologs and Evolution for MUC3B Gene

Paralogs for MUC3B Gene

(3) SIMAP similar genes for MUC3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MUC3B: view

No data available for Paralogs for MUC3B Gene

Variants for MUC3B Gene

Sequence variations from dbSNP and Humsavar for MUC3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_029507 -
VAR_029508 -

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MUC3B Gene

Disorders for MUC3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MUC3B Gene - From: NovoSeek

Disorder Aliases PubMed IDs
barrett esophagus/esophageal adenocarcinoma
  • barrett's esophagus
- elite association
Search MUC3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC3B
genes like me logo Genes that share disorders with MUC3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC3B Gene

Publications for MUC3B Gene

  1. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. (PMID: 10973822) Pratt W.S. … Swallow D.M. (Biochem. Biophys. Res. Commun. 2000) 2 23 67
  2. Expression of beta-catenin and its mechanism of delocalization in intestinal-type early gastric cancer based on mucin expression. (PMID: 19475529) Lee S.H. … Park d.o. .Y. (Histol. Histopathol. 2009) 23 67
  3. Predictors for squamous re-epithelialization of Barrett's esophagus after endoscopic biopsy. (PMID: 17565646) Amano Y. … Kinoshita Y. (J. Gastroenterol. Hepatol. 2007) 23 67
  4. PAR-2 activation increases human intestinal mucin secretion through EGFR transactivation. (PMID: 18028876) Jarry A. … Darmoul D. (Biochem. Biophys. Res. Commun. 2007) 23 67
  5. Evaluation of modified crystal violet chromoendoscopy procedure using new mucosal pit pattern classification for detection of Barrett's dysplastic lesions. (PMID: 16542886) Yuki T. … Kinoshita Y. (Dig Liver Dis 2006) 23 67

Products for MUC3B Gene

Sources for MUC3B Gene

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