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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MUC3B Gene

protein-coding   GIFtS: 35
GCID: GC07Pg99965          (predicted)

Mucin 3B, Cell Surface Associated

(Previous name: mucin 3B)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mucin 3B, Cell Surface Associated1 2     MUC32
Intestinal Mucin-3B2 3     MUC3A2
MUC-3B2 3     Intestinal Mucin MUC3B2
Mucin 3B1     mucin-3B2

External Ids:    HGNC: 133841   Entrez Gene: 578762   OMIM: 6056335   UniProtKB: Q9H1953   

Export aliases for MUC3B gene to outside databases

Previous GC identifers: GC07P099084 GC07P100147 GC07P100160 GC07P100158 GC07P100191 GC07P100332 GC07P100547 GC07U903146


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MUC3B Gene: 
MUC3B (mucin 3B, cell surface associated) is a protein-coding gene. Diseases associated with MUC3B include barrett's esophagus, and ulcerative colitis, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification.

UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195
Function: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating
barrier against particles and infectious agents at mucosal surfaces (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MUC3B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MUC3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC3B


Genomic Location:
Chromosome:7   

Entrez Gene cytogenetic band: 7q22   HGNC cytogenetic band: 7q22

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07Pg99965:       (about GC identifiers)

Start:
99,964,572 bp from start of contig CRA_TCAGchr7v2      End:
99,969,297 bp from start of contig CRA_TCAGchr7v2
Size:
4,726 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195 (See protein sequence)
Recommended Name: Mucin-3B precursor  
Size: 1237 amino acids; 131402 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q6W762 Q7LDU5 Q9GZZ2 Q9UN95

Explore the universe of human proteins at neXtProt for MUC3B: NX_Q9H195

Post-translational modifications:

  • UniProtKB: Highly O-glycosylated and probably also N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H195

  • MUC3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    Reactome Protein details: Q9H195
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005796Golgi lumen TAS--
    GO:0016021integral to membrane IEA--

    MUC3B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MUC: Mucins

    3 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR000082 SEA_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q9H195

    ProtoNet protein and cluster: Q9H195

    1 Blocks protein domain: IPB000082 SEA domain

    UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 SEA domain


    MUC3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC3B_HUMAN, Q9H195
    Function: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating
    barrier against particles and infectious agents at mucosal surfaces (By similarity)

    Animal Models:

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MUC3B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Termination of O-glycan biosynthesis0.41
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for MUC3B
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Termination of O-glycan biosynthesis



    MUC3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUC3B

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MUC3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MUC3B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MUC3B

    3 Novoseek inferred chemical compound relationships for MUC3B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 55.7 1 7864366 (1)
    oligonucleotide 8.49 1 2254452 (1)
    tyrosine 3.06 1 11289722 (1)

    Search CenterWatch for drugs/clinical trials and news about MUC3B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
    Products:
         
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    3 AceView cDNA sequences:

    BI005786 BF844624 AY307931 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MUC3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MUC3B Expression
    About this image


    Genevestigator expression for MUC3B

    UniProtKB/Swiss-Prot: MUC3B_HUMAN, Q9H195
    Tissue specificity: Fetal and adult small intestine and fetal and adult colon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MUC3B gene
    4 SIMAP similar genes for MUC3B using alignment to 3 protein entries:     MUC3B_HUMAN (see all proteins):
    MUC3A    LOC100131514    MUC12    NOTCH2

    MUC3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in MUC3B are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0295084
    ----see VAR_0295082 H Y mis40--------
    VAR_0295074
    ----see VAR_0295072 A V mis40--------

    HapMap Linkage Disequilibrium report for MUC3B (99964572 - 99969297 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MUC3B: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MUC3B
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605633    OMIM disorders: --

    9 diseases for MUC3B:    About MalaCards
    barrett's esophagus    ulcerative colitis    cystic fibrosis    colon cancer
    crohn's disease    colon adenocarcinoma    adenocarcinoma    gastric cancer
    colorectal cancer


    MUC3B for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MUC3B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    barrett esophagus 50.4 8 16803684 (8)
    colon cancer 49.7 4 8110187 (2), 12198708 (1), 1728605 (1)
    cystic fibrosis 13.2 2 2254452 (1), 8500875 (1)
    adenocarcinoma 12.5 1 1550588 (1)


    Export disorders for MUC3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MUC3B gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with MUC3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. (PubMed id 10973822)1, 2, 3, 9 Pratt W.S....Swallow D.M. (2000)
    2. Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus. (PubMed id 12958310)1, 2, 9 Gum J.R. Jr.... Kim Y.S. (2003)
    3. Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. (PubMed id 11289722)1, 2, 9 Kyo K.... Nakamura Y. (2001)
    4. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. (PubMed id 10405327)1, 2 Williams S.J.... McGuckin M.A. (1999)
    5. MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region. (PubMed id 9334251)1, 2 Gum J.R. Jr.... Kim Y.S. (1997)
    6. Expression of mucin 3 and mucin 5AC in arthritic synovial tissue. (PubMed id 18163520)1 Volin M.V....Koch A.E. (2008)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1 Hillier L.W.... Wilson R.K. (2003)
    8. Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin. (PubMed id 10512748)1 Crawley S.C.... Kim Y.S. (1999)
    9. Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. (PubMed id 2393399)1 Gum J.R. Jr.... Kim Y.S. (1990)
    10. Prevalence of and risk factors for Barrett's esophagu s with intestinal predominant mucin phenotype. (PubMed id 16803684)9 Amano Y....Kinoshita Y. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57876 HGNC: 13384 AceView: MUC3B.1 euGenes: HUgn57876 ECgene: MUC3B
    H-InvDB: MUC3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MUC3B Pharmacogenomics, SNPs, Pathways
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MUC3B gene:
    Search GeneIP for patents involving MUC3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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