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Aliases for MUC3A Gene

Aliases for MUC3A Gene

  • Mucin 3A, Cell Surface Associated 2 3 5
  • MUC-3A 3 4
  • MUC3 3 4
  • Mucin 3A, Intestinal 2
  • Mucin 3, Intestinal 3
  • Intestinal Mucin-3A 4
  • Intestinal Mucin 3

External Ids for MUC3A Gene

Previous HGNC Symbols for MUC3A Gene

  • MUC3

Previous GeneCards Identifiers for MUC3A Gene

  • GC07U990056
  • GC07P100161
  • GC07P100196
  • GC07Ph99598
  • GC07Ph99599
  • GC07Ph99600
  • GC07P100385
  • GC07P100549
  • GC07P100550

Summaries for MUC3A Gene

Entrez Gene Summary for MUC3A Gene

  • The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]

GeneCards Summary for MUC3A Gene

MUC3A (Mucin 3A, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC3A include Hypertrichotic Osteochondrodysplasia and Cap Polyposis. Among its related pathways are Diseases associated with O-glycosylation of proteins and Defective GALNT12 causes colorectal cancer 1 (CRCS1). GO annotations related to this gene include extracellular matrix structural constituent and extracellular matrix constituent, lubricant activity. An important paralog of this gene is MUC17.

UniProtKB/Swiss-Prot for MUC3A Gene

  • Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.

Gene Wiki entry for MUC3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC3A Gene

Genomics for MUC3A Gene

Regulatory Elements for MUC3A Gene

Enhancers for MUC3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MUC3A on UCSC Golden Path with GeneCards custom track

Genomic Location for MUC3A Gene

Chromosome:
7
Start:
100,949,117 bp from pter
End:
100,968,347 bp from pter
Size:
19,231 bases
Orientation:
Plus strand

Genomic View for MUC3A Gene

Genes around MUC3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC3A Gene

Proteins for MUC3A Gene

  • Protein details for MUC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02505-MUC3A_HUMAN
    Recommended name:
    Mucin-3A
    Protein Accession:
    Q02505
    Secondary Accessions:
    • A6NP22
    • O14650
    • O14651
    • O43418
    • O43421
    • Q02506
    • Q6W763
    • Q9H3Q7
    • Q9UKW9
    • Q9UN93
    • Q9UN94
    • Q9UN95

    Protein attributes for MUC3A Gene

    Size:
    3323 amino acids
    Molecular mass:
    345127 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA63772.1; Type=Miscellaneous discrepancy; Note=This sequence is incomplete at 5 and 3 ends and extensively differs from that shown.; Evidence={ECO:0000305}; Sequence=AAA63773.1; Type=Miscellaneous discrepancy; Note=This sequence is incomplete at 5 and 3 ends and extensively differs from that shown.; Evidence={ECO:0000305}; Sequence=AAC02271.1; Type=Frameshift; Positions=1535, 1542, 1548; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC3A Gene

Proteomics data for MUC3A Gene at MOPED

Post-translational modifications for MUC3A Gene

Other Protein References for MUC3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC3A Gene

Domains & Families for MUC3A Gene

Gene Families for MUC3A Gene

HGNC:

Protein Domains for MUC3A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02505

UniProtKB/Swiss-Prot:

MUC3A_HUMAN :
  • Contains 1 EGF-like domain.
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 SEA domain.
genes like me logo Genes that share domains with MUC3A: view

Function for MUC3A Gene

Molecular function for MUC3A Gene

UniProtKB/Swiss-Prot Function:
Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.

Gene Ontology (GO) - Molecular Function for MUC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with MUC3A: view

Phenotypes for MUC3A Gene

genes like me logo Genes that share phenotypes with MUC3A: view

miRNA for MUC3A Gene

miRTarBase miRNAs that target MUC3A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC3A Gene

Localization for MUC3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC3A Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC3A Gene COMPARTMENTS Subcellular localization image for MUC3A gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 3
plasma membrane 3
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MUC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with MUC3A: view

Pathways & Interactions for MUC3A Gene

genes like me logo Genes that share pathways with MUC3A: view

Interacting Proteins for MUC3A Gene

Selected Interacting proteins: Q02505-MUC3A_HUMAN for MUC3A Gene via I2D

Symbol External ID(s) Details
MYC
TFF3

Gene Ontology (GO) - Biological Process for MUC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MUC3A: view

No data available for SIGNOR curated interactions for MUC3A Gene

Drugs & Compounds for MUC3A Gene

(5) Drugs for MUC3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for MUC3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MUC3A: view

Transcripts for MUC3A Gene

mRNA/cDNA for MUC3A Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC3A Gene

Mucin 3A, cell surface associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC3A Gene

No ASD Table

Relevant External Links for MUC3A Gene

GeneLoc Exon Structure for
MUC3A
ECgene alternative splicing isoforms for
MUC3A

Expression for MUC3A Gene

mRNA expression in normal human tissues for MUC3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC3A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.5), Colon - Transverse (x9.9), Liver (x8.1), and Prostate (x5.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUC3A Gene



SOURCE GeneReport for Unigene cluster for MUC3A Gene Hs.744422

mRNA Expression by UniProt/SwissProt for MUC3A Gene

Q02505-MUC3A_HUMAN
Tissue specificity: Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.
genes like me logo Genes that share expression patterns with MUC3A: view

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for MUC3A Gene

Orthologs for MUC3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC3A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia A630081J09Rik 35
  • 75.2 (n)
  • 66.26 (a)
Muc3a 16
A630081J09Rik 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MUC3A 35
  • 97.52 (n)
  • 97.3 (a)
MUC3A 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MUC3A 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUC3A 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MUC3A 36
  • 20 (a)
OneToOne
Species with no ortholog for MUC3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC3A Gene

ENSEMBL:
Gene Tree for MUC3A (if available)
TreeFam:
Gene Tree for MUC3A (if available)

Paralogs for MUC3A Gene

Paralogs for MUC3A Gene

(3) SIMAP similar genes for MUC3A Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for MUC3A Gene

genes like me logo Genes that share paralogs with MUC3A: view

Variants for MUC3A Gene

Sequence variations from dbSNP and Humsavar for MUC3A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_030722 -
VAR_030723 -
VAR_030724 -
rs1141046 -- 100,967,585(+) CTGGC(C/T)CTGGT utr-variant-3-prime
rs7792083 -- 100,967,619(+) CTGCC(C/T)GTTTC utr-variant-3-prime

Variation tolerance for MUC3A Gene

Gene Damage Index Score: 13.88; 95.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC3A Gene

Human Gene Mutation Database (HGMD)
MUC3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC3A Gene

Disorders for MUC3A Gene

MalaCards: The human disease database

(7) MalaCards diseases for MUC3A Gene - From: ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertrichotic osteochondrodysplasia
  • cantu syndrome
cap polyposis
  • cap inflammatory polyposis
colorectal cancer 1
  • colorectal cancer, susceptibility to, 1
renal clear cell carcinoma
  • clear cell carcinoma of kidney
dysentery
  • infectious diarrhea
- elite association - COSMIC cancer census association via MalaCards
Search MUC3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC3A

Genetic Association Database (GAD)
MUC3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC3A
genes like me logo Genes that share disorders with MUC3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC3A Gene

Publications for MUC3A Gene

  1. Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. (PMID: 2393399) Gum J.R. Jr. … Kim Y.S. (Biochem. Biophys. Res. Commun. 1990) 2 3 4 67
  2. Quantitative RT-PCR assay for MUC3 and VEGF mRNA in renal clear cell carcinoma: relationship with nuclear grade and prognosis. (PMID: 14550470) Leroy X. … Porchet N. (Urology 2003) 3 23
  3. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. (PMID: 10973822) Pratt W.S. … Swallow D.M. (Biochem. Biophys. Res. Commun. 2000) 2 3
  4. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. (PMID: 10405327) Williams S.J. … McGuckin M.A. (Biochem. Biophys. Res. Commun. 1999) 3 23
  5. MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region. (PMID: 9334251) Gum J.R. Jr. … Kim Y.S. (J. Biol. Chem. 1997) 3 23

Products for MUC3A Gene

Sources for MUC3A Gene

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