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Aliases for MUC3A Gene

Aliases for MUC3A Gene

  • Mucin 3A, Cell Surface Associated 2 3
  • MUC-3A 3 4
  • MUC3 3 4
  • Mucin 3A, Intestinal 2
  • Mucin 3, Intestinal 3
  • Intestinal Mucin-3A 4
  • Intestinal Mucin 3
  • Mucin-3A 3

External Ids for MUC3A Gene

Previous HGNC Symbols for MUC3A Gene

  • MUC3

Previous GeneCards Identifiers for MUC3A Gene

  • GC07U990056
  • GC07P100161
  • GC07P100196
  • GC07Ph99598
  • GC07Ph99599
  • GC07Ph99600
  • GC07P100385
  • GC07P100549
  • GC07P100550

Summaries for MUC3A Gene

Entrez Gene Summary for MUC3A Gene

  • The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]

GeneCards Summary for MUC3A Gene

MUC3A (Mucin 3A, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC3A include cap polyposis and renal clear cell carcinoma. GO annotations related to this gene include extracellular matrix structural constituent and extracellular matrix constituent, lubricant activity. An important paralog of this gene is MUC17.

UniProtKB/Swiss-Prot for MUC3A Gene

  • Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.

Gene Wiki entry for MUC3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC3A Gene

Genomics for MUC3A Gene

Genomic Location for MUC3A Gene

Start:
100,949,454 bp from pter
End:
100,968,346 bp from pter
Size:
18,893 bases
Orientation:
Plus strand

Genomic View for MUC3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC3A Gene

No data available for Regulatory Elements for MUC3A Gene

Proteins for MUC3A Gene

  • Protein details for MUC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02505-MUC3A_HUMAN
    Recommended name:
    Mucin-3A
    Protein Accession:
    Q02505
    Secondary Accessions:
    • O14650
    • O14651
    • O43418
    • O43421
    • Q02506
    • Q6W763
    • Q9H3Q7
    • Q9UKW9
    • Q9UN93
    • Q9UN94
    • Q9UN95

    Protein attributes for MUC3A Gene

    Size:
    2541 amino acids
    Molecular mass:
    265918 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MUC3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC3A Gene

Proteomics data for MUC3A Gene at MOPED

Post-translational modifications for MUC3A Gene

Other Protein References for MUC3A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC3A Gene

Domains for MUC3A Gene

Gene Families for MUC3A Gene

HGNC:

Protein Domains for MUC3A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02505

UniProtKB/Swiss-Prot:

MUC3A_HUMAN :
  • Q02505
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 SEA domain.
genes like me logo Genes that share domains with MUC3A: view

Function for MUC3A Gene

Molecular function for MUC3A Gene

UniProtKB/Swiss-Prot Function: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.

Gene Ontology (GO) - Molecular Function for MUC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent NAS 10405327
GO:0005515 protein binding --
GO:0030197 extracellular matrix constituent, lubricant activity NAS 9334251
genes like me logo Genes that share ontologies with MUC3A: view

Phenotypes for MUC3A Gene

GenomeRNAi human phenotypes for MUC3A:
genes like me logo Genes that share phenotypes with MUC3A: view

miRNA for MUC3A Gene

miRTarBase miRNAs that target MUC3A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MUC3A Gene

Localization for MUC3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC3A Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC3A Gene COMPARTMENTS Subcellular localization image for MUC3A gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MUC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 9334251
GO:0005796 Golgi lumen TAS --
GO:0016021 integral component of membrane NAS 10405327
genes like me logo Genes that share ontologies with MUC3A: view

Pathways for MUC3A Gene

SuperPathways for MUC3A Gene

No Data Available

Interacting Proteins for MUC3A Gene

Selected Interacting proteins: Q02505-MUC3A_HUMAN for MUC3A Gene via I2D

Symbol External ID(s) Details
MYC
TFF3

Gene Ontology (GO) - Biological Process for MUC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC3A: view

No data available for Pathways by source for MUC3A Gene

Compounds for MUC3A Gene

(11) Novoseek inferred chemical compound relationships for MUC3A Gene

Compound -log(P) Hits PubMed IDs
cesium chloride 53.2 1
periodate 38.4 1
methotrexate 20.1 1
oligonucleotide 12.5 2
galactose 7.77 1
genes like me logo Genes that share compounds with MUC3A: view

Transcripts for MUC3A Gene

mRNA/cDNA for MUC3A Gene

(9) Additional mRNA sequences :
(7) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC3A Gene

Mucin 3A, cell surface associated:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MUC3A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC3A Gene

No ASD Table

Relevant External Links for MUC3A Gene

GeneLoc Exon Structure for
MUC3A
ECgene alternative splicing isoforms for
MUC3A

Expression for MUC3A Gene

mRNA expression in normal human tissues for MUC3A Gene

mRNA differential expression in normal tissues according to GTEx for MUC3A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (19.5), Colon - Transverse (9.9), Liver (8.1), and Prostate (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MUC3A Gene

SOURCE GeneReport for Unigene cluster for MUC3A Gene Hs.744422

mRNA Expression by UniProt/SwissProt for MUC3A Gene

Q02505-MUC3A_HUMAN
Tissue specificity: Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.
genes like me logo Genes that share expressions with MUC3A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MUC3A Gene

Orthologs for MUC3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC3A 35
  • 97.52 (n)
  • 97.3 (a)
MUC3A 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MUC3A 36
  • 43 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A630081J09Rik 35
  • 75.2 (n)
  • 66.26 (a)
A630081J09Rik 36
  • 57 (a)
OneToOne
Gm7534 16
platypus
(Ornithorhynchus anatinus)
Mammalia MUC3A 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MUC3A 36
  • 20 (a)
OneToOne
Species with no ortholog for MUC3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC3A Gene

ENSEMBL:
Gene Tree for MUC3A (if available)
TreeFam:
Gene Tree for MUC3A (if available)

Paralogs for MUC3A Gene

Paralogs for MUC3A Gene

Selected SIMAP similar genes for MUC3A Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for MUC3A Gene

genes like me logo Genes that share paralogs with MUC3A: view

Variants for MUC3A Gene

Sequence variations from dbSNP and Humsavar for MUC3A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2904850 -- 100,960,515(+) CACCC(A/C)TCCCC synonymous-codon, reference, intron-variant, upstream-variant-2KB
rs2904851 -- 100,960,710(+) GAGGT(C/G)AGGCT intron-variant, upstream-variant-2KB
rs2904852 -- 100,960,786(+) CAGGG(A/C)CAGTG synonymous-codon, reference, utr-variant-5-prime
rs2904853 -- 100,961,269(+) gatta(A/G)aagtc intron-variant
rs2904854 -- 100,961,304(+) atcaa(A/G)gcgtc intron-variant

Relevant External Links for MUC3A Gene

HapMap Linkage Disequilibrium report
MUC3A
Human Gene Mutation Database (HGMD)
MUC3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC3A Gene

Disorders for MUC3A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MUC3A Gene including...

Search for MUC3A Gene in MalaCards »

(1) University of Copenhagen DISEASES for MUC3A Gene

(30) Novoseek inferred disease relationships for MUC3A Gene

Disease -log(P) Hits PubMed IDs
metaplasia 56.1 6
adenocarcinoma 51.9 5
colitis ulcerative 46.8 2
neoplastic transformation 44.4 1
carcinoma bronchioloalveolar 42.7 2

Relevant External Links for MUC3A

Genetic Association Database (GAD)
MUC3A
genes like me logo Genes that share disorders with MUC3A: view

No data available for UniProtKB/Swiss-Prot for MUC3A Gene

Publications for MUC3A Gene

  1. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. (PMID: 10405327) Williams S.J. … McGuckin M.A. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  2. MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region. (PMID: 9334251) Gum J.R. Jr. … Kim Y.S. (J. Biol. Chem. 1997) 3 4 23
  3. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. (PMID: 10973822) Pratt W.S. … Swallow D.M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  4. Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. (PMID: 2393399) Gum J.R. Jr. … Kim Y.S. (Biochem. Biophys. Res. Commun. 1990) 2 3 4
  5. Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin. (PMID: 10512748) Crawley S.C. … Kim Y.S. (Biochem. Biophys. Res. Commun. 1999) 3 4

Products for MUC3A Gene

Sources for MUC3A Gene

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