Aliases for MUC3A Gene
External Ids for MUC3A Gene
Previous HGNC Symbols for MUC3A Gene
Previous GeneCards Identifiers for MUC3A Gene
The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]
GeneCards Summary for MUC3A Gene
MUC3A (Mucin 3A, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC3A include Cap Polyposis and Hypertrichotic Osteochondrodysplasia. Among its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and CLEC7A (Dectin-1) signaling. GO annotations related to this gene include extracellular matrix structural constituent and extracellular matrix constituent, lubricant activity. An important paralog of this gene is MUC17.
UniProtKB/Swiss-Prot for MUC3A Gene
Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.