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Aliases for MUC22 Gene

Aliases for MUC22 Gene

  • Mucin 22 2 3 5
  • Panbronchiolitis-Related Mucin-Like Protein 1 3 4
  • PBMUCL1 3 4
  • Panbronchiolitis Related Mucin-Like 1 2
  • Mucin-22 3
  • G4 4

External Ids for MUC22 Gene

Previous GeneCards Identifiers for MUC22 Gene

  • GC06Po30916
  • GC06P030979

Summaries for MUC22 Gene

GeneCards Summary for MUC22 Gene

MUC22 (Mucin 22) is a Protein Coding gene. An important paralog of this gene is MUC21.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC22 Gene

Genomics for MUC22 Gene

Regulatory Elements for MUC22 Gene

Enhancers for MUC22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031007 0.9 Ensembl ENCODE 19.5 +2.0 2017 1.0 CTCF ZNF362 JUND BHLHE40 SIN3A FOS RAD21 EZH2 HCG21 MUC22 DPCR1 LY6G5C PSORS1C1 GC06P031175
GH06G030527 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.2 -476.9 -476922 3.5 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 IER3 PRR3 MICD GNL1 HCG18 ABCF1 HLA-C TRIM39 C6orf136 PPP1R10
GH06G031516 0.7 ENCODE 9.1 +510.8 510805 1.1 ZNF680 MCM3 RNF2 MAFG CEBPB MCM7 CEBPA GLIS1 NFE2 EMSY MICB LOC101929072 MUC22 ENSG00000256851 PPIAP9
GH06G030792 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.6 -212.1 -212097 2.1 ELF3 TBP TBL1XR1 ZBTB40 RARA ZNF207 SMARCA5 ZBTB11 JUNB ELF1 IER3 VARS2 FLOT1 LINC00243 DDR1 DDR1-AS1 GTF2H4 HCG20 DPCR1 HLA-E
GH06G031353 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +350.2 350240 7.0 HDGF PKNOX1 ATF1 ZNF493 WRNIP1 ZFP64 SIN3A NSD2 ZNF2 GLIS2 HLA-C LY6G5B CCHCR1 PPT2 LSM2 ATF6B DDX39B HLA-B ENSG00000271581 TCF19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MUC22 on UCSC Golden Path with GeneCards custom track

Genomic Location for MUC22 Gene

Chromosome:
6
Start:
31,005,952 bp from pter
End:
31,035,570 bp from pter
Size:
29,619 bases
Orientation:
Plus strand

Genomic View for MUC22 Gene

Genes around MUC22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MUC22 Gene

  • Protein details for MUC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E2RYF6-MUC22_HUMAN
    Recommended name:
    Mucin-22
    Protein Accession:
    E2RYF6
    Secondary Accessions:
    • H3BQR8

    Protein attributes for MUC22 Gene

    Size:
    1773 amino acids
    Molecular mass:
    173478 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MUC22 Gene

Post-translational modifications for MUC22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MUC22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC22 Gene

Domains & Families for MUC22 Gene

Gene Families for MUC22 Gene

HGNC:

Protein Domains for MUC22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC22: view

No data available for UniProtKB/Swiss-Prot for MUC22 Gene

Function for MUC22 Gene

Molecular function for MUC22 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by poly(I:C).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUC22 Gene

Localization for MUC22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC22 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MUC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MUC22: view

No data available for Subcellular locations from COMPARTMENTS for MUC22 Gene

Pathways & Interactions for MUC22 Gene

SuperPathways for MUC22 Gene

No Data Available

Interacting Proteins for MUC22 Gene

Gene Ontology (GO) - Biological Process for MUC22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MUC22 Gene

Drugs & Compounds for MUC22 Gene

No Compound Related Data Available

Transcripts for MUC22 Gene

mRNA/cDNA for MUC22 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC22 Gene

Mucin 22:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC22 Gene

No ASD Table

Relevant External Links for MUC22 Gene

GeneLoc Exon Structure for
MUC22
ECgene alternative splicing isoforms for
MUC22

Expression for MUC22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUC22 Gene

mRNA differential expression in normal tissues according to GTEx for MUC22 Gene

This gene is overexpressed in Esophagus - Mucosa (x31.9) and Vagina (x16.5).

NURSA nuclear receptor signaling pathways regulating expression of MUC22 Gene:

MUC22

SOURCE GeneReport for Unigene cluster for MUC22 Gene:

Hs.582967

mRNA Expression by UniProt/SwissProt for MUC22 Gene:

E2RYF6-MUC22_HUMAN
Tissue specificity: Expressed in lung by serous cells of the submucosal gland (at protein level). Detected in the placenta, lung and testis.

Evidence on tissue expression from TISSUES for MUC22 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with MUC22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC22 Gene

Orthologs for MUC22 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUC22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC22 34
  • 91.03 (n)
dog
(Canis familiaris)
Mammalia MUC22 35
  • 29 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9573 35
  • 23 (a)
OneToOne
Species where no ortholog for MUC22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC22 Gene

ENSEMBL:
Gene Tree for MUC22 (if available)
TreeFam:
Gene Tree for MUC22 (if available)

Paralogs for MUC22 Gene

Variants for MUC22 Gene

Sequence variations from dbSNP and Humsavar for MUC22 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000069205 -- 31,012,720(+) ACCAA(C/T)AGTGT intron-variant
rs1000099448 -- 31,021,928(+) CACTG(G/T)TTTTA intron-variant
rs1000334988 -- 31,017,458(+) TGTCT(A/C)GCTCA intron-variant
rs1000463453 -- 31,021,239(+) AAATA(C/G)ACCAA intron-variant
rs1000619275 -- 31,030,033(+) TCTTC(C/T)ACCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MUC22 Gene

Variant ID Type Subtype PubMed ID
dgv10370n54 CNV loss 21841781
dgv1091e199 CNV deletion 23128226
dgv1092e199 CNV deletion 23128226
esv1151879 CNV insertion 17803354
esv24694 CNV loss 19812545
esv2660020 CNV deletion 23128226
esv2670269 CNV deletion 23128226
esv2677358 CNV deletion 23128226
esv2678235 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv2731801 CNV deletion 23290073
esv2731802 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3567515 CNV deletion 23714750
esv3567516 CNV deletion 23714750
esv3567517 CNV deletion 23714750
esv3570899 CNV loss 25503493
esv3608519 CNV loss 21293372
esv3608521 CNV loss 21293372
esv3608522 CNV loss 21293372
esv3608523 CNV loss 21293372
nsv1023108 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv517797 CNV loss 19592680
nsv518538 CNV gain 19592680
nsv519229 CNV loss 19592680
nsv528807 CNV loss 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv601487 CNV loss 21841781

Variation tolerance for MUC22 Gene

Gene Damage Index Score: 36.89; 99.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MUC22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC22 Gene

Disorders for MUC22 Gene

Relevant External Links for MUC22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC22

No disorders were found for MUC22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MUC22 Gene

Publications for MUC22 Gene

  1. Molecular cloning of two novel mucin-like genes in the disease- susceptibility locus for diffuse panbronchiolitis. (PMID: 20981447) Hijikata M. … Keicho N. (Hum. Genet. 2011) 2 3 4 64
  2. Genome-Wide Association Study of Pre-Eclampsia Detects Novel Maternal Single Nucleotide Polymorphisms and Copy-Number Variants in Subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort. (PMID: 23551011) Zhao L. … Dewan A.T. (Ann. Hum. Genet. 2013) 3 64
  3. Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. (PMID: 21900946) Nakabayashi K. … Shirasawa S. (J. Hum. Genet. 2011) 3 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for MUC22 Gene

Sources for MUC22 Gene

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