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MUC22 Gene

protein-coding   GIFtS: 28
GCID: GC06P030979

Mucin 22

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mucin 221 2
PBMUCL12 3 5
Panbronchiolitis Related Mucin-Like 11 2
Panbronchiolitis-Related Mucin-Like Protein 12 3
mucin-222
G43

External Ids:    HGNC: 397551   Entrez Gene: 1005076792   Ensembl: ENSG000002612727   OMIM: 6139175   UniProtKB: E2RYF63   

Export aliases for MUC22 gene to outside databases

Previous GC identifer: GC06Po30916


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MUC22 Gene:
MUC22 (mucin 22) is a protein-coding gene. Diseases associated with MUC22 include diffuse panbronchiolitis, and graves' disease. An important paralog of this gene is MUC21.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  NT_167246.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MUC22
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MUC22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

MUC22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC22 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030979:  view genomic region     (about GC identifiers)

Start:
30,973,729 bp from pter      End:
31,003,179 bp from pter
Size:
29,451 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167247 2,355,676-2,385,126      Chr6+,NT_167246 2,307,538-2,351,537      Chr6+,NT_113891.2 2,485,649-2,515,202     
Chr6+,NT_167244 2,285,367-2,315,159      Chr6+,NT_167249 2,305,960-2,335,435      Chr6+,NT_167248 2,267,156-2,296,635     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MUC22_HUMAN, E2RYF6 (See protein sequence)
Recommended Name: Mucin-22 precursor  
Size: 1773 amino acids; 173478 Da
Secondary accessions: H3BQR8

Explore the universe of human proteins at neXtProt for MUC22: NX_E2RYF6

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001185744.1  
    ENSEMBL proteins: 
     ENSP00000455906  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MUC: Mucins

    1 InterPro protein domain:
     IPR028199 Mucin_dom

    Graphical View of Domain Structure for InterPro Entry E2RYF6

    ProtoNet protein and cluster: E2RYF6


    MUC22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC22_HUMAN, E2RYF6
    Induction: Up-regulated by poly(I:C)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MUC22
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUC22_HUMAN, E2RYF6: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    MUC22 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MUC22
    Interactions:

        Search GeneGlobe Interaction Network for MUC22

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010812negative regulation of cell-substrate adhesion IEA--
    GO:0022408negative regulation of cell-cell adhesion IEA--

    MUC22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MUC22



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MUC22 gene: 
    NM_001198815.1  

    Unigene Cluster for MUC22:

    Mucin 22
    Hs.582967  [show with all ESTs]
    Unigene Representative Sequence: AB600271
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000561890(uc021yug.1 uc021yuh.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB560770.1 AB600271.1 AB600272.1 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    MUC22 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.582967

    UniProtKB/Swiss-Prot: MUC22_HUMAN, E2RYF6
    Tissue specificity: Expressed in lung by serous cells of the submucosal gland (at protein level). Detected in the
    placenta, lung and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for MUC22 (if available)
    TreeFam Gene Tree for MUC22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MUC22 gene
    MUC212  

    MUC22 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MUC22
    PGOHUM00000262464


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MUC22 (see all 1029)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs16328561,2
    C,F,A--30971736(-) TTAAAG/ATATAT 1 -- us2k112Minor allele frequency- A:0.15NS NA EA CSA WA 978
    rs16328551,2
    C,F,H--30971769(-) AGCTAT/CAATTT 1 -- us2k111Minor allele frequency- C:0.09NS EA NA CSA 684
    rs1824593631,2
    --30971878(+) GGGAGC/GCTGAG 1 -- us2k10--------
    rs1380780701,2
    --30971896(+) GATCAC/GTTGAG 1 -- us2k10--------
    rs1867814541,2
    C--30971975(+) CCATGC/TGCGGT 1 -- us2k10--------
    rs1417250021,2
    --30971976(+) CATGCA/GCGGTG 1 -- us2k10--------
    rs1501754191,2
    --30971985(+) TGGTGC/TGCGCC 1 -- us2k10--------
    rs25239131,2
    C,A,H--30972034(+) CACTTG/CAACCT 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs28446681,2
    C,F,H--30972121(-) TTTTTT/AAAATT 1 -- us2k117Minor allele frequency- A:0.19NS EA NA WA CSA 919
    rs3678057741,2
    C--30972121(+) AATTT-/A/TAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MUC22 (30973729 - 31003179 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MUC22 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731801CNV Deletion23290073
    dgv1091e199CNV Deletion23128226
    esv2670269CNV Deletion23128226
    esv2660020CNV Deletion23128226
    dgv1092e199CNV Deletion23128226
    esv2677358CNV Deletion23128226
    esv2731802CNV Deletion23290073
    esv2731791CNV Deletion23290073
    esv2678235CNV Deletion23128226
    esv1151879CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MUC22
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613917    OMIM disorders: --

    8 diseases for MUC22:    
    About MalaCards
    diffuse panbronchiolitis    graves' disease    pre-eclampsia    eclampsia
    hyperglycemia    pneumonia    systemic lupus erythematosus    lupus erythematosus


    MUC22 for disorders           About GeneDecksing


    Export disorders for MUC22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MUC22 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MUC22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of two novel mucin-like genes in the disease- susceptibility locus for diffuse panbronchiolitis. (PubMed id 20981447)1, 2, 3 Hijikata M.... Keicho N. (Hum. Genet. 2011)
    2. Genome-Wide Association Study of Pre-Eclampsia Detects Novel Maternal Single Nucleotide Polymorphisms and Copy-Number Variants in Subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort. (PubMed id 23551011)1 Zhao L....Dewan A.T. (Ann. Hum. Genet. 2013)
    3. Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. (PubMed id 21900946)1 Nakabayashi K....Shirasawa S. (J. Hum. Genet. 2011)
    4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100507679 HGNC: 39755 Ensembl:ENSG00000261272 euGenes: HUgn100507679 ECgene: MUC22
    H-InvDB: MUC22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MUC22 Pharmacogenomics, SNPs, Pathways
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MUC22 gene:
    Search GeneIP for patents involving MUC22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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