MUC22 Gene
protein-coding GIFtS: 26
GCID: GC06P030979
|
|
mucin 22
| |
Aliases
for MUC22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mucin 221 2 | | PBMUCL11 2 3 | | Panbronchiolitis-Related Mucin-Like Protein 12 3 | | Mucin-221 | | Panbronchiolitis Related Mucin-Like 12 | | G43 |
Export aliases for MUC22 gene to outside databasesPrevious GC identifer: GC06Po30916 |
Summaries
for MUC22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MUC22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1 NT_167249.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MUC22
Other transcription factors
Search SABiosciences Chromatin IP Primers for MUC22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33MUC22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P030979: view genomic region
(about GC identifiers)
Start:
|
30,978,251 bp from pter |
End:
|
31,003,179 bp from pter |
Size:
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24,929 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr6+,ALT_REF_LOCI_7 30,915,621-30,924,436 |
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Proteins
for MUC22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MUC22_HUMAN, E2RYF6 (See
protein sequence)Recommended Name: Mucin-22 precursor Size: 1773 amino acids; 173478 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: H3BQR8Explore the universe of human proteins at neXtProt for MUC22: NX_E2RYF6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_E2RYF6
MUC22 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001185744.1
ENSEMBL proteins: ENSP00000455906
Human Recombinant Protein Products for MUC22:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MUC22 for ontologies About GeneDecksing
MUC22 Antibody Products:
Assay Products for MUC22: |
Protein
Domains /
Families
for MUC22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: E2RYF6 |
Function
for MUC22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MUC22_HUMAN, E2RYF6Induction: Up-regulated by poly(I:C)Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC22 |
|
Pathways & Interactions
for MUC22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUC22
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010812 | negative regulation of cell-substrate adhesion |
-- | -- | | GO:0022408 | negative regulation of cell-cell adhesion |
-- | -- |
MUC22 for ontologies About GeneDecksing
|
Drugs & Compounds
for MUC22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MUC22
Search CenterWatch for drugs/clinical trials and news about MUC22 
|
Transcripts
for MUC22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MUC22 gene: NM_001198815.1 Unigene Cluster for MUC22: Mucin 22 Hs.582967 [show with all ESTs]Unigene Representative Sequence: AB6002711 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000561890(uc021yug.1 uc021yuh.1)
Additional cDNA sequence: AB560770.1 AB600271.1 AB600272.1
GeneLoc Exon Structure
|
Expression
for MUC22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SOURCE GeneReport for Unigene cluster: Hs.582967
UniProtKB/Swiss-Prot: MUC22_HUMAN, E2RYF6Tissue specificity: Expressed in lung by serous cells of the submucosal gland (at protein level). Detected in theplacenta, lung and testis
SABiosciences Custom PCR Arrays for MUC22
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MUC22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC22 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC22 |
Orthologs
for MUC22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MUC22 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
Uncharacterized protein |
8(a) |
1 ↔ 1 |
5(15799424-15806578) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Muc55B6 |
Mucin 55B |
7(a) |
1 ↔ 1 |
2R(13937731-13939610) |
worm
(Caenorhabditis elegans) |
Secernentea |
ZC178.21 |
Protein ZC178.2 |
41.77(n)
32.73(a) |
|
191093 NM_072842.1 NP_505243.1 |
ENSEMBL Gene Tree for MUC22 (if available)
TreeFam Gene Tree for MUC22 (if available) |
Paralogs
for MUC22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MUC22 gene
- LOC1001315142 MUC162 MUC3A2 MUC122 MUC172
MUC22 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MUC22
PGOHUM00000262464
|
Genomic Variants
for MUC22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MUC22 (30978251 - 31003179 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MUC22: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MUC22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MUC22 for disorders About GeneDecksing
OMIM gene information: 613917
OMIM disorders: --
4  diseases for MUC22: About MalaCardspanbronchiolitis diffuse panbronchiolitis systemic lupus erythematosus lupus erythematosus
Export disorders for MUC22 gene to outside databases
|
Publications
for MUC22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MUC22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MUC22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of two novel mucin-like genes in th e disease-susceptibility locus for diffuse panbronchiolitis. (PubMed id 20981447)1, 2, 3 Hijikata M....Keicho N. (2010)
- Identification of independent risk loci for Graves' di sease within the MHC in the Japanese population. (PubMed id 21900946)1 Nakabayashi K....Shirasawa S. (2011)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
|
External Searches for MUC22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MUC22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MUC22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUC22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Mucin database | http://www.medkem.gu.se/mucinbiology/databases/ |
|
| | |
About This Section
| Patent Information for MUC22 gene:
Search GeneIP for patents involving MUC22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MUC22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUC22 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC22 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC22 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC22 |
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| | | | Search Tocris compounds for MUC22 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC22 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MUC22 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC22 |
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