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Aliases for MUC21 Gene

Aliases for MUC21 Gene

  • Mucin 21, Cell Surface Associated 2 3
  • Epiglycanin 2 3 4
  • C6orf205 3 4
  • MUC-21 3 4
  • Chromosome 6 Open Reading Frame 205 2
  • KMQK697 3

External Ids for MUC21 Gene

Previous HGNC Symbols for MUC21 Gene

  • C6orf205

Previous GeneCards Identifiers for MUC21 Gene

  • GC06P031060
  • GC06P030951
  • GC06P030751

Summaries for MUC21 Gene

GeneCards Summary for MUC21 Gene

MUC21 (Mucin 21, Cell Surface Associated) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and O-linked glycosylation. An important paralog of this gene is MUC22.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC21 Gene

Genomics for MUC21 Gene

Regulatory Elements for MUC21 Gene

Genomic Location for MUC21 Gene

Chromosome:
6
Start:
30,983,708 bp from pter
End:
30,989,903 bp from pter
Size:
6,196 bases
Orientation:
Plus strand

Genomic View for MUC21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MUC21 Gene

  • Protein details for MUC21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SSG8-MUC21_HUMAN
    Recommended name:
    Mucin-21
    Protein Accession:
    Q5SSG8
    Secondary Accessions:
    • B0UZT7
    • B4DQ55
    • C9JMK2
    • D9N007
    • Q0VGF1
    • Q3B7T2
    • Q5SS94
    • Q6UXC5

    Protein attributes for MUC21 Gene

    Size:
    566 amino acids
    Molecular mass:
    54228 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Could be considered as a marker for lung carcinomas
    SequenceCaution:
    • Sequence=AAI05737.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC21 Gene

Proteomics data for MUC21 Gene at MOPED

Post-translational modifications for MUC21 Gene

Other Protein References for MUC21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC21 Gene

Domains & Families for MUC21 Gene

Gene Families for MUC21 Gene

HGNC:

Protein Domains for MUC21 Gene

Suggested Antigen Peptide Sequences for MUC21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC21: view

No data available for UniProtKB/Swiss-Prot for MUC21 Gene

Function for MUC21 Gene

Phenotypes for MUC21 Gene

genes like me logo Genes that share phenotypes with MUC21: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC21 Gene

Localization for MUC21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC21 Gene

Cell membrane; Single-pass type I membrane protein; Extracellular side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC21 Gene COMPARTMENTS Subcellular localization image for MUC21 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MUC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MUC21: view

Pathways & Interactions for MUC21 Gene

genes like me logo Genes that share pathways with MUC21: view

Interacting Proteins for MUC21 Gene

Gene Ontology (GO) - Biological Process for MUC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC21: view

No data available for SIGNOR curated interactions for MUC21 Gene

Drugs & Compounds for MUC21 Gene

No Compound Related Data Available

Transcripts for MUC21 Gene

mRNA/cDNA for MUC21 Gene

(3) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC21 Gene

Mucin 21, cell surface associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC21 Gene

No ASD Table

Relevant External Links for MUC21 Gene

GeneLoc Exon Structure for
MUC21
ECgene alternative splicing isoforms for
MUC21

Expression for MUC21 Gene

mRNA expression in normal human tissues for MUC21 Gene

mRNA differential expression in normal tissues according to GTEx for MUC21 Gene

This gene is overexpressed in Esophagus - Mucosa (x32.5), Vagina (x9.2), Cervix - Ectocervix (x6.3), and Minor Salivary Gland (x4.6).

Protein differential expression in normal tissues from HIPED for MUC21 Gene

This gene is overexpressed in Esophagus (31.8), Saliva (28.6), and Cervix (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC21 Gene



SOURCE GeneReport for Unigene cluster for MUC21 Gene Hs.448277

mRNA Expression by UniProt/SwissProt for MUC21 Gene

Q5SSG8-MUC21_HUMAN
Tissue specificity: Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchial epithelial cells.
genes like me logo Genes that share expression patterns with MUC21: view

Protein tissue co-expression partners for MUC21 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MUC21 Gene

Orthologs for MUC21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUC21 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MUC21 35
  • 70.51 (n)
  • 55.64 (a)
chimpanzee
(Pan troglodytes)
Mammalia MUC21 35
  • 94.08 (n)
  • 92.96 (a)
MUC21 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9573 16
Species with no ortholog for MUC21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC21 Gene

ENSEMBL:
Gene Tree for MUC21 (if available)
TreeFam:
Gene Tree for MUC21 (if available)

Paralogs for MUC21 Gene

Paralogs for MUC21 Gene

genes like me logo Genes that share paralogs with MUC21: view

Variants for MUC21 Gene

Sequence variations from dbSNP and Humsavar for MUC21 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs143989844 untested, untested 30,986,712(+) AGCAC(A/T)GCCAC reference, synonymous-codon, nc-transcript-variant
rs146848216 untested, untested 30,983,986(+) TTCTC(A/C)TTATG missense, reference, nc-transcript-variant
rs149194643 untested, untested 30,986,550(+) GAGTC(C/T)AGCAC reference, synonymous-codon, nc-transcript-variant
rs267600948 untested, untested 30,983,975(+) GAAAG(A/G)AAATG missense, reference, nc-transcript-variant
rs267600949 untested, untested 30,986,993(+) CAACT(C/T)TGAGT reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MUC21 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
esv2670269 CNV Deletion 23128226
nsv462744 CNV Loss 19166990
esv2677358 CNV Deletion 23128226
esv2731799 CNV Deletion 23290073
esv5663 CNV Loss 19470904
esv2731800 CNV Deletion 23290073
dgv6535n71 CNV Loss 21882294

Variation tolerance for MUC21 Gene

Residual Variation Intolerance Score: 99.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.82; 83.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC21 Gene

HapMap Linkage Disequilibrium report
MUC21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC21 Gene

Disorders for MUC21 Gene

Relevant External Links for MUC21

Genetic Association Database (GAD)
MUC21
Human Genome Epidemiology (HuGE) Navigator
MUC21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC21
genes like me logo Genes that share disorders with MUC21: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MUC21 Gene

Publications for MUC21 Gene

  1. Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. (PMID: 17977904) Itoh Y. … Irimura T. (Glycobiology 2008) 2 67
  2. Genome-Wide Association Study of Pre-Eclampsia Detects Novel Maternal Single Nucleotide Polymorphisms and Copy-Number Variants in Subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort. (PMID: 23551011) Zhao L. … Dewan A.T. (Ann. Hum. Genet. 2013) 67
  3. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PMID: 23263863) Li J. … Sleiman P.M. (Hum. Mol. Genet. 2013) 67
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  5. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PMID: 23284291) Hancock D.B. … London S.J. (PLoS Genet. 2012) 67

Products for MUC21 Gene

Sources for MUC21 Gene

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