MUC21 Gene
protein-coding GIFtS: 40
GCID: GC06P030951
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mucin 21, cell surface associated(Previous name: chromosome 6 open reading frame 205 )
(Previous symbol: C6orf205)
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Aliases
for MUC21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mucin 21, Cell Surface Associated1 2 | | KMQK6972 | | C6orf2051 2 3 | | Epiglycanin3 | | BCX31G15.21 | | Mucin-211 | | MUC-212 3 | | Epiglycanin3 | | Chromosome 6 Open Reading Frame 2051 | | |
Export aliases for MUC21 gene to outside databasesPrevious GC identifers: GC06P031060 GC06P030751 |
Summaries
for MUC21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MUC21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MUC21 gene promoter:
TBP STAT1 AML1a C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for MUC21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.32 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33MUC21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P030951: view genomic region
(about GC identifiers)
Start:
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30,951,485 bp from pter |
End:
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30,957,680 bp from pter |
Size:
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6,196 bases |
Orientation:
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plus strand |
6 alternative locations:
| Chr6+,ALT_REF_LOCI_4 30,919,230-30,925,515 | Chr6+,ALT_REF_LOCI_5 30,944,854-30,951,049 | Chr6+,ALT_REF_LOCI_3 30,953,237-30,959,422 | | Chr6+,ALT_REF_LOCI_1 30,968,027-30,974,212 | Chr6+,ALT_REF_LOCI_6 30,976,654-30,983,044 | Chr6+,ALT_REF_LOCI_2 30,980,369-30,986,569 | |
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Proteins
for MUC21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MUC21_HUMAN, Q5SSG8 (See
protein sequence)Recommended Name: Mucin-21 precursor Size: 566 amino acids; 54228 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein; Extracellular side
Miscellaneous: Could be considered as a marker for lung carcinomas
Sequence caution: Sequence=AAI05737.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B0UZT7 B4DQ55 C9JMK2 D9N007 Q0VGF1 Q3B7T2 Q5SS94 Q6UXC5Alternative splicing: 3 isoforms: Q5SSG8-1 Q5SSG8-2 Q5SSG8-3 Explore the universe of human proteins at neXtProt for MUC21: NX_Q5SSG8
Post-translational modifications:
O-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SSG8
MUC21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010909.2
ENSEMBL proteins: ENSP00000457640 ENSP00000365473 Reactome Protein details: Q5SSG8
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MUC21 for ontologies About GeneDecksing
MUC21 Antibody Products:
Assay Products for MUC21: |
Protein
Domains /
Families
for MUC21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5SSG8 |
Function
for MUC21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC21
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MUC21 (NM_001010909) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUC21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUC21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC21 |
|
Pathways & Interactions
for MUC21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for MUC21 (see all 8)
MUC21 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUC21
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016266 | O-glycan processing |
TAS | -- | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
MUC21 for ontologies About GeneDecksing
|
Drugs & Compounds
for MUC21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MUC21 for compounds About GeneDecksing
 Browse Tocris compounds for MUC21
1 PharmGKB related drug/compound annotation for MUC21 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about MUC21
|
Transcripts
for MUC21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MUC21 gene: NM_001010909.2 Unigene Cluster for MUC21: Mucin 21, cell surface associated Hs.448277 [show with all ESTs]Unigene Representative Sequence: NM_0010109092 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486149 ENST00000376296(uc003nsh.2 uc003nsi.1 uc021yuf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC21
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MUC21 (NM_001010909) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUC21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUC21 |
Additional cDNA sequence: AB242595.1 AK056612.1 AK298642.1 AK299471.1 AK301645.1 AK316363.1 AY358415.1 BC105735.1 BC105736.1 BC105737.1 BC107478.1 HM596784.1 4 DOTS entries: DT.99976641 DT.95300203 DT.95122412 DT.121344318 6 AceView cDNA sequences: AL602765 AK056612 BU733613 AL703190 CD696619 AY358415
GeneLoc Exon Structure
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Expression
for MUC21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MUC21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCCCCCA
About this image
See MUC21 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.448277
UniProtKB/Swiss-Prot: MUC21_HUMAN, Q5SSG8Tissue specificity: Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchialepithelial cells
SABiosciences Custom PCR Arrays for MUC21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MUC21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC21 |
Orthologs
for MUC21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MUC21 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for MUC21 (if available)
TreeFam Gene Tree for MUC21 (if available) |
Paralogs
for MUC21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MUC21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MUC21 (30951485 - 30957680 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MUC21
1 Indel: 62493 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC21 |
|
Disorders
/ Diseases
for MUC21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MUC21 for disorders About GeneDecksing
5  diseases for MUC21: About MalaCardssystemic lupus erythematosus lupus erythematosus lung carcinoma carcinoma
toxic epidermal necrolysis
1 disease from the University of Copenhagen DISEASES database for MUC21:Breast carcinoma Human Genome Epidemiology (HuGE) Navigator: MUC21 (2 documents)
Export disorders for MUC21 gene to outside databases
|
Publications
for MUC21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MUC21 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MUC21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. (PubMed id 17977904)1, 2, 3 Itoh Y.... Irimura T. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- A genome-wide association study identifies two new ris k loci for Graves' disease. (PubMed id 21841780)1 Chu X....Song H.D. (2011)
- Genome-wide association study of Stevens-Johnson Synd rome and Toxic Epidermal Necrolysis in Europe. (PubMed id 21801394)1 GAcnin E....Mockenhaupt M. (2011)
- Mucin 21/epiglycanin modulates cell adhesion. (PubMed id 20388707)1 Yi Y....Irimura T. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
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External Searches for MUC21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MUC21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MUC21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUC21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MUC21 | Pharmacogenomics, SNPs, Pathways | | Mucin database | http://www.medkem.gu.se/mucinbiology/databases/ |
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About This Section
| Patent Information for MUC21 gene:
Search GeneIP for patents involving MUC21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MUC21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MUC21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MUC21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC21 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MUC21 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MUC21 | | OriGene Custom Protein Services for MUC21 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUC21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC21 |
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 |  |  |  | |
| | | | Search Tocris compounds for MUC21 |
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 | | | MUC21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC21 |
|  |  |  | | | | Search ThermoFisher Antibodies for MUC21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUC21 |
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