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Aliases for MUC21 Gene

Aliases for MUC21 Gene

  • Mucin 21, Cell Surface Associated 2 3
  • Epiglycanin 2 3 4
  • C6orf205 3 4
  • MUC-21 3 4
  • Chromosome 6 Open Reading Frame 205 2
  • Mucin-21 3
  • KMQK697 3

External Ids for MUC21 Gene

Previous Symbols for MUC21 Gene

  • C6orf205

Summaries for MUC21 Gene

GeneCards Summary for MUC21 Gene

MUC21 (Mucin 21, Cell Surface Associated) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. An important paralog of this gene is MUC22.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC21 Gene

Genomics for MUC21 Gene

Genomic Location for MUC21 Gene

Start:
30,983,708 bp from pter
End:
30,989,903 bp from pter
Size:
6,196 bases
Orientation:
Plus strand

Genomic View for MUC21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for MUC21 Gene

Proteins for MUC21 Gene

  • Protein details for MUC21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SSG8-MUC21_HUMAN
    Recommended name:
    Mucin-21
    Protein Accession:
    Q5SSG8
    Secondary Accessions:
    • B0UZT7
    • B4DQ55
    • C9JMK2
    • D9N007
    • Q0VGF1
    • Q3B7T2
    • Q5SS94
    • Q6UXC5

    Protein attributes for MUC21 Gene

    Size:
    566 amino acids
    Molecular mass:
    54228 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Could be considered as a marker for lung carcinomas
    SequenceCaution:
    • Sequence=AAI05737.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC21 Gene

Proteomics data for MUC21 Gene at MOPED

Post-translational modifications for MUC21 Gene

Other Protein References for MUC21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC21 Gene

Domains for MUC21 Gene

Gene Families for MUC21 Gene

HGNC:

Protein Domains for MUC21 Gene

genes like me logo Genes that share domains with MUC21: view

No data available for UniProtKB/Swiss-Prot for MUC21 Gene

Function for MUC21 Gene

miRNA for MUC21 Gene

miRTarBase miRNAs that target MUC21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MUC21 Gene

Localization for MUC21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC21 Gene

Cell membrane; Single-pass type I membrane protein; Extracellular side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC21 Gene COMPARTMENTS Subcellular localization image for MUC21 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MUC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MUC21: view

Pathways for MUC21 Gene

genes like me logo Genes that share pathways with MUC21: view

Interacting Proteins for MUC21 Gene

Gene Ontology (GO) - Biological Process for MUC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC21: view

Transcripts for MUC21 Gene

mRNA/cDNA for MUC21 Gene

(3) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC21 Gene

Mucin 21, cell surface associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC21 Gene

No ASD Table

Relevant External Links for MUC21 Gene

GeneLoc Exon Structure for
MUC21
ECgene alternative splicing isoforms for
MUC21

Expression for MUC21 Gene

mRNA expression in normal human tissues for MUC21 Gene

mRNA differential expression in normal tissues according to GTEx for MUC21 Gene

This gene is overexpressed in Esophagus - Mucosa (32.5), Vagina (9.2), Cervix - Ectocervix (6.3), and Minor Salivary Gland (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MUC21 Gene

SOURCE GeneReport for Unigene cluster for MUC21 Gene Hs.448277

mRNA Expression by UniProt/SwissProt for MUC21 Gene

Q5SSG8-MUC21_HUMAN
Tissue specificity: Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchial epithelial cells.
genes like me logo Genes that share expressions with MUC21: view

Orthologs for MUC21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUC21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC21 36
  • 94.08 (n)
  • 92.96 (a)
MUC21 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MUC21 36
  • 70.51 (n)
  • 55.64 (a)
mouse
(Mus musculus)
Mammalia Gm9573 16
Species with no ortholog for MUC21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC21 Gene

ENSEMBL:
Gene Tree for MUC21 (if available)
TreeFam:
Gene Tree for MUC21 (if available)

Paralogs for MUC21 Gene

Paralogs for MUC21 Gene

genes like me logo Genes that share paralogs with MUC21: view

Variants for MUC21 Gene

Sequence variations from dbSNP and Humsavar for MUC21 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs886403 -- 30,989,841(+) CCATC(C/T)TGTGG utr-variant-3-prime
rs1625781 -- 30,987,096(+) AGTAC(A/G)ACCTC synonymous-codon, reference
rs1634713 -- 30,983,243(+) TCAGT(A/T)ATACT upstream-variant-2KB
rs1634714 -- 30,983,784(+) ACGCC(C/T)GAGTC utr-variant-5-prime
rs1634730 - 30,986,468(+) CACAG(C/T)GTCCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MUC21 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
esv2670269 CNV Deletion 23128226
nsv462744 CNV Loss 19166990
esv2677358 CNV Deletion 23128226
esv2731799 CNV Deletion 23290073
esv5663 CNV Loss 19470904
esv2731800 CNV Deletion 23290073
dgv6535n71 CNV Loss 21882294

Relevant External Links for MUC21 Gene

HapMap Linkage Disequilibrium report
MUC21

Disorders for MUC21 Gene

(1) University of Copenhagen DISEASES for MUC21 Gene

Relevant External Links for MUC21

Genetic Association Database (GAD)
MUC21
Human Genome Epidemiology (HuGE) Navigator
MUC21
genes like me logo Genes that share disorders with MUC21: view

No data available for UniProtKB/Swiss-Prot for MUC21 Gene

Publications for MUC21 Gene

  1. Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. (PMID: 17977904) Itoh Y. … Irimura T. (Glycobiology 2008) 2 3 4
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. (PMID: 21801394) GAcnin E. … Mockenhaupt M. (Orphanet J Rare Dis 2011) 3 49

Products for MUC21 Gene

Sources for MUC21 Gene

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