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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MUC20 Gene

protein-coding   GIFtS: 53
GCID: GC03P195447

Mucin 20, Cell Surface Associated

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mucin 20, Cell Surface Associated1 2
MUC-202 3
mucin-202
Transmembrane Mucin MUC20S2
KIAA13593

External Ids:    HGNC: 232821   Entrez Gene: 2009582   Ensembl: ENSG000001769457   OMIM: 6103605   UniProtKB: Q8N3073   

Export aliases for MUC20 gene to outside databases

Previous GC identifers: GC03P196775 GC03P196937 GC03P192723 GC03P195343


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MUC20 Gene:
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by
many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is
localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein
associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some
downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies
in most individuals. The allele represented in the human reference assembly contains 12 copies. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for MUC20 Gene: 
MUC20 (mucin 20, cell surface associated) is a protein-coding gene. Diseases associated with MUC20 include iga glomerulonephritis, and glomerulonephritis, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification.

UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307
Function: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient
MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced
proliferation of MMP1 and MMP9 expression

Gene Wiki entry for MUC20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_029928.13  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MUC20 gene promoter:
         IRF-2   AML1a   Meis-1a   AP-4   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMUC20 promoter sequence
   Search SABiosciences Chromatin IP Primers for MUC20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

MUC20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC20 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P195447:  view genomic region     (about GC identifiers)

Start:
195,447,753 bp from pter      End:
195,467,994 bp from pter
Size:
20,242 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307 (See protein sequence)
Recommended Name: Mucin-20 precursor  
Size: 709 amino acids; 71982 Da
Subunit: Interacts with MET; oligomerization increases affinity for MET
Subcellular location: Secreted (Potential). Apical cell membrane. Basolateral cell membrane. Cell projection,
microvillus membrane
Sequence caution: Sequence=AAQ88814.1; Type=Frameshift; Positions=638; Sequence=BAA92597.1; Type=Miscellaneous
discrepancy; Note=Dubious isoform. Probable cloning artifact;
Secondary accessions: Q6UX97 Q76I83 Q76I85 Q86ST8 Q8NBY6 Q96KA1 Q9P2I8
Alternative splicing: 2 isoforms:  Q8N307-1   Q8N307-3   

Explore the universe of human proteins at neXtProt for MUC20: NX_Q8N307

Explore proteomics data for MUC20 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N307

  • MUC20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MUC20 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269435.1  NP_001091986.1  NP_689886.2  

    ENSEMBL proteins: 
     ENSP00000414350   ENSP00000396774   ENSP00000405629   ENSP00000397774   ENSP00000325431  
    Reactome Protein details: Q8N307
    Human Recombinant Protein Products for MUC20: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MUC20 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005796Golgi lumen TAS--
    GO:0009925basal plasma membrane IDA15314156
    GO:0016324apical plasma membrane IEA--
    GO:0031528microvillus membrane IEA--

    MUC20 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MUC: Mucins

    ProtoNet protein and cluster: Q8N307


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC20_HUMAN, Q8N307
    Function: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient
    MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced
    proliferation of MMP1 and MMP9 expression

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MUC20 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Muc20 (no phenotypes)

    MUC20 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Muc20tm1Lex for MUC20

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MUC20 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MUC20

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    hsa-miR-3658 hsa-miR-198
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MUC20 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Termination of O-glycan biosynthesis0.41
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Development HGF signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MUC20
        Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

    4        Reactome Pathways for MUC20
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Termination of O-glycan biosynthesis



    MUC20 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUC20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for MUC20 (Q8N3073 ENSP000003967744) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METP085813, ENSP000003172724I2D: score=1 STRING: ENSP00000317272
    B3GNT3ENSP000003218744STRING: ENSP00000321874
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    C1GALT1C1ENSP000003043644STRING: ENSP00000304364
    GCNT4ENSP000003170274STRING: ENSP00000317027
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0048012hepatocyte growth factor receptor signaling pathway IEA--

    MUC20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MUC20

    Search CenterWatch for drugs/clinical trials and news about MUC20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MUC20 gene (3 alternative transcripts): 
    NM_001282506.1  NM_001098516.1  NM_152673.2  

    Unigene Cluster for MUC20:

    Mucin 20, cell surface associated
    Hs.308992  [show with all ESTs]
    Unigene Representative Sequence: NM_001098516
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447234 ENST00000436408 ENST00000485430 ENST00000480350 ENST00000445522
    ENST00000498018 ENST00000423938 ENST00000320736(uc010hzo.3 uc010hzp.3 uc011bte.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MUC20:
    hsa-miR-3658 hsa-miR-198
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC20

    Additional mRNA sequence: 

    AB037780.1 AB098731.1 AK027314.1 AK075138.1 AK298316.1 AK311504.1 AY358449.1 BC029267.1 
    BC044243.1 

    14 DOTS entries:

    DT.100783850  DT.95338274  DT.120927799  DT.92053291  DT.120927751  DT.306429  DT.95298029  DT.100023175 
    DT.213055  DT.95157199  DT.75119681  DT.120927535  DT.40297366  DT.91875210 

    24/104 AceView cDNA sequences (see all 104):

    AI884517 T32433 AI380576 AW188713 AA989663 BQ707897 AI561306 AA535954 
    AA447211 BU674325 BM554766 BM820502 BC073879 BM668163 AI591335 CD366632 
    Z41747 C00498 AW438692 AI553680 BU740479 BM697386 AI803847 BM721408 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MUC20 expression in normal human tissues (normalized intensities)      MUC20 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGTGTTT
    MUC20 Expression
    About this image


    MUC20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Epidermis (Integumentary System)
     
     Kidney (Urinary System)
     
     Dermis (Integumentary System)

    See MUC20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MUC20

    SOURCE GeneReport for Unigene cluster: Hs.308992

    UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307
    Tissue specificity: Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive
    system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in
    most of the male urogenital tract epithelia, with the exception of epididymis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MUC20 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Muc201 , 5 mucin 201, 5 62.37(n)1
    45.81(a)1
      16 (23.34 cM)5
    2241161  NM_146071.21  NP_666183.21 
     327774195 
    lizard
    (Anolis carolinensis)
    Reptilia MUC46
    Uncharacterized protein
    2(a)
    possible ortholog
    GL343433.1(112703-138343)
    zebrafish
    (Danio rerio)
    Actinopterygii --
    CU681842.36
    (see all 7)
    --
    4(a)
    3(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    8(2360706-2381987)
    3(5590506-5620216)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48356
    Muc68Ca6
    (see all 4)
    Mucin 68Ca
    (see all 4)
    4(a)
    2(a)
    (see all 4)
    many ↔ many
    possible ortholog
    (see all 4)
    3L(5472890-5476763)
    3L(11603765-11613172)
    worm
    (Caenorhabditis elegans)
    Secernentea W05F2.76
    Protein W05F2.7
    3(a)
    possible ortholog
    I(3352463-3359433)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MUC16
    GPI-anchored cell surface glycoprotein (flocculin)...
    2(a)
    1 → many
    IX(389572-393675)


    ENSEMBL Gene Tree for MUC20 (if available)
    TreeFam Gene Tree for MUC20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MUC20 gene
    14 SIMAP similar genes for MUC20 using alignment to 8 protein entries:     MUC20_HUMAN (see all proteins):
    pp12301    HC6    KIAA0101    FLJ00047    C14orf23    COQ5
    GALK2    TUBA1C    MST132    C21orf37    PFKFB3    C12orf76
    SEC14L3    RBP7

    MUC20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307
    Polymorphism: The region encoding the tandem repeats is highly polymorphic. Divergence of the number of tandem
    repeats was seen in different cDNA libraries


    10/723 SNPs in MUC20 are shown (see all 723)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009626271,2
    C--195445764(+) GGCTGG/TTTTTT 1 -- us2k10--------
    rs40371081,2
    C,A,H--195445771(-) AAAAAA/CAAAAA 1 -- us2k14Minor allele frequency- C:0.00NA WA CSA 7
    rs2006207681,2
    C--195445771(+) TTTTT-/G/    
       GTTTT
    TTTTT
    1 -- us2k10--------
    rs716270071,2
    C--195445772(-) AAAAA-/A/AA  
            
    CAAAA
    1 -- us2k11NA 2
    rs3758638931,2
    C--195445773(+) TTTTT-/GTTTTTTT 2 -- us2k1 cds11Minor allele frequency- GTT:0.00NA 2
    rs786868921,2
    C--195445775(+) TGTTTG/TTTTTT 1 -- us2k10--------
    rs569664291,2
    C--195445868(+) TCTCCC/TAAAAT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1136296741,2
    C--195445882(+) TCTCAG/CTTTGG 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs46118531,2
    C,A,H--195445973(-) aacgcC/Tctttc 1 -- us2k1 trp33Minor allele frequency- T:0.17NA CSA 6
    rs26885341,2
    C,F,A,H--195446037(-) tttacG/Ataaac 1 -- us2k110Minor allele frequency- A:0.46NA WA CSA 24

    HapMap Linkage Disequilibrium report for MUC20 (195447753 - 195467994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/43 variations for MUC20 (see all 43):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv905e199CNV Deletion23128226
    esv2726488CNV Deletion23290073
    esv2726490CNV Deletion23290073
    esv2726489CNV Deletion23290073
    dgv906e199CNV Deletion23128226
    esv2726477CNV Deletion23290073
    nsv820762CNV Duplication20802225
    nsv471428CNV Duplication19718026
    nsv821242CNV Duplication20802225
    nsv436752CNV Insertion17901297

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610360    OMIM disorders: --

    5 diseases for MUC20:    About MalaCards
    iga glomerulonephritis    glomerulonephritis    laryngitis    pneumonia
    prostatitis


    MUC20 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MUC20
    Human Genome Epidemiology (HuGE) Navigator: MUC20 (2 documents)

    Export disorders for MUC20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MUC20 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with MUC20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy. (PubMed id 16508246)1, 2, 4 Li G....Wang H. (2006)
    2. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. (PubMed id 14565953)1, 2, 3 Higuchi T....Nakamura M. (2004)
    3. MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. (PubMed id 15314156)1, 2, 9 Higuchi T.... Nakamura M. (2004)
    4. [Variable number of tandem repeats polymorphism of MUC20 is associated with the progression of IgA nephropathy] (PubMed id 16029633)1, 4 Li G.S....Wang H.Y. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. (PubMed id 18834073)1 Samuels T.L....Johnston N. (2008)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200958 HGNC: 23282 AceView: MUC20 Ensembl:ENSG00000176945 euGenes: HUgn200958
    ECgene: MUC20 H-InvDB: MUC20

    (According to HUGE)
    About This Section
    HUGE: KIAA1359

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MUC20 Pharmacogenomics, SNPs, Pathways
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MUC20 gene:
    Search GeneIP for patents involving MUC20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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