Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MUC20 Gene

protein-coding   GIFtS: 53
GCID: GC03P195343

mucin 20, cell surface associated

 Explore 6 diseases affiliated with
MUC20 via our new
 Human Malady Compendium 
Biological research products
for MUC20
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mucin 20, Cell Surface Associated1 2
KIAA13591 3
MUC-202 3
FLJ144081
Mucin-201
Transmembrane Mucin MUC20S2

External Ids:    HGNC: 232821   Entrez Gene: 2009582   Ensembl: ENSG000001769457   OMIM: 6103605   UniProtKB: Q8N3073   

Export aliases for MUC20 gene to outside databases

Previous GC identifers: GC03P196775 GC03P196937 GC03P195447 GC03P192723


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MUC20:
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many
epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the
plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the
multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling
cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in most individuals. The
allele represented in the human reference assembly contains 12 copies. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307
Function: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK
activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation
of MMP1 and MMP9 expression

Gene Wiki entry for MUC20


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MUC20 gene promoter:
         IRF-2   AML1a   Meis-1a   AP-4   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMUC20 promoter sequence
   Search SABiosciences Chromatin IP Primers for MUC20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

MUC20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC20 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P195343:  view genomic region     (about GC identifiers)

Start:
195,343,316 bp from pter      End:
195,467,994 bp from pter
Size:
124,679 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307 (See protein sequence)
Recommended Name: Mucin-20 precursor  
Size: 709 amino acids; 71982 Da
Subunit: Interacts with MET; oligomerization increases affinity for MET
Subcellular location: Secreted (Potential). Apical cell membrane. Basolateral cell membrane. Cell projection,
microvillus membrane
Sequence caution: Sequence=AAQ88814.1; Type=Frameshift; Positions=638; Sequence=BAA92597.1; Type=Miscellaneous
discrepancy; Note=Dubious isoform. Probable cloning artifact;
Secondary accessions: Q6UX97 Q76I83 Q76I85 Q86ST8 Q8NBY6 Q96KA1 Q9P2I8
Alternative splicing: 2 isoforms:  Q8N307-1   Q8N307-3   

Explore the universe of human proteins at neXtProt for MUC20: NX_Q8N307

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N307

  • MUC20 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091986.1  NP_689886.2  

    ENSEMBL proteins: 
     ENSP00000414350   ENSP00000396774   ENSP00000405629   ENSP00000397774   ENSP00000371380  
     ENSP00000325431  
    Reactome Protein details: Q8N307
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for MUC20 
    GenScript Custom Purified and Recombinant Proteins Services for MUC20
    Novus Biologicals MUC20 Protein
    Novus Biologicals MUC20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MUC20

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005796Golgi lumen TAS--
    GO:0009925basal plasma membrane IDA15314156
    GO:0016324apical plasma membrane IEA--
    GO:0031528microvillus membrane IEA--


    MUC20 for ontologies           About GeneDecksing



    MUC20 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MUC20 
    GenScript Custom Superior Antibodies Services for MUC20
    Novus Biologicals MUC20 Antibodies
    Search for Antibodies for MUC20 at Abcam  
    Uscn Antibodies for MUC20
    ThermoFisher Antibodies for MUC20

    Assay Products for MUC20: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MUC20
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MUC20


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N307


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307
    Function: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK
    activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation
    of MMP1 and MMP9 expression

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): MUC20
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MUC20
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MUC20:
    hsa-miR-3658 hsa-miR-198
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MUC20 (see all 7)
    OriGene shRNA RFP: MUC20
    OriGene siRNA: MUC20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MUC20

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC20 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC20 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MUC20 (NM_001098516)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUC20 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MUC20
    Search LifeMap BioReagents cell lines for MUC20

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC20

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    MUC20 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Muc20tm1Lex for MUC20
         1 MGI phenotypic allele for Muc20 (no phenotypes)

    MUC20 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein1.00
    Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein1.00
    Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein1.00
    Termination of O-glycan biosynthesis0.69
    Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein1.00
    O-linked glycosylation of mucins0.28
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.15
    3Development HGF signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.23

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for MUC20 
        Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

    5/8        Reactome Pathways for MUC20 (see all 8)
        Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein



    MUC20 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUC20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for MUC20 (Q8N3073 ENSP000003967744) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METP085813, ENSP000003172724I2D: score=1 STRING: ENSP00000317272
    B3GNT3ENSP000003218744STRING: ENSP00000321874
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    C1GALT1C1ENSP000003043644STRING: ENSP00000304364
    GCNT4ENSP000003170274STRING: ENSP00000317027
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0048012hepatocyte growth factor receptor signaling pathway IEA--


    MUC20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MUC20
    Search CenterWatch for drugs/clinical trials and news about MUC20 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MUC20 gene (2 alternative transcripts): 
    NM_001098516.1  NM_152673.2  

    Unigene Cluster for MUC20:

    Mucin 20, cell surface associated
    Hs.308992  [show with all ESTs]
    Unigene Representative Sequence: NM_001098516
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447234 ENST00000436408 ENST00000485430 ENST00000480350 ENST00000445522
    ENST00000498018 ENST00000423938 ENST00000381954 ENST00000320736(uc010hzo.3 uc010hzp.3 uc011bte.1)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): MUC20
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MUC20
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MUC20:
    hsa-miR-3658 hsa-miR-198
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MUC20 (see all 7)
    OriGene shRNA RFP: MUC20
    OriGene siRNA: MUC20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC20
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC20 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC20 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MUC20 (NM_001098516)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUC20 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC20
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MUC20
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC20
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC20

    Additional cDNA sequence: 

    AB037780.1 AB098731.1 AK027314.1 AK075138.1 AK298316.1 AK311504.1 AY358449.1 BC029267.1 
    BC044243.1 

    15 DOTS entries:

    DT.100783850  DT.95338274  DT.120927799  DT.92053291  DT.120927751  DT.306429  DT.95298029  DT.213055 
    DT.100023175  DT.95157199  DT.75119681  DT.120927535  DT.40297366  DT.91875210  DT.95177684 

    24/104 AceView cDNA sequences (see all 104):

    AI553680 BU740479 AI803847 T33321 BU674325 AA989663 AA366320 BC064564 
    AI884517 AW188713 AW438692 BF194882 T32433 AA447211 BC073879 BQ707897 
    BM668163 AI921127 AI591335 Z41747 BM697386 AI380576 AI561306 BM721408 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MUC20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTGTGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MUC20 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Human kidney epithelial cell spheroids (Kidney spheroids for...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MUC20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MUC20

    SOURCE GeneReport for Unigene cluster: Hs.308992

    UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307
    Tissue specificity: Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In
    the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the
    male urogenital tract epithelia, with the exception of epididymis

        SABiosciences Custom PCR Arrays for MUC20
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC20
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MUC20
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC20
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MUC20 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    1(a)
    1 ↔ 1
    Un(3781222-3781857)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01111604.16
    --
    2(a)
    1 ↔ 1
    Zv9_NA113(22-9777)
    fruit fly
    (Drosophila melanogaster)
    Insecta Muc68D6
    Muc12Ea6
    Mucin 12Ea
    3(a)
    1(a)
    possible ortholog
    1 ↔ 1
    3L(11760399-11765257)
    X(14171862-14182073)
    worm
    (Caenorhabditis elegans)
    Secernentea F59A6.36
    Protein F59A6.3
    3(a)
    1 ↔ 1
    II(5008334-5011172)


    ENSEMBL Gene Tree for MUC20 (if available)
    TreeFam Gene Tree for MUC20 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MUC20_HUMAN, Q8N307
    Polymorphism: The region encoding the tandem repeats is highly polymorphic. Divergence of the number of tandem repeats
    was seen in different cDNA libraries


    10/570 NCBI SNPs in MUC20 are shown (see all 570    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392515851,2
    C--195445767(+) TGTTT-/TTTTG 
            
    TTTTT
    1 -- us2k10--------
    rs1132514121,2
    C--195445771(+) TTTTTT/GTTTTT 1 -- us2k13Minor allele frequency- G:0.00NA WA CSA 5
    rs786868921,2
    C--195445775(+) TGTTTG/TTTTTT 1 -- us2k10--------
    rs569664291,2
    C--195445868(+) TCTCCC/TAAAAT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs46118531,2
    C,A,H--195445973(-) AACGCC/TCTTTC 1 -- us2k1 trp33Minor allele frequency- T:0.17NA CSA 6
    rs26885341,2
    C,F,A,H,--195446037(-) TTTACG/ATAAAC 1 -- us2k110Minor allele frequency- A:0.46NA WA CSA 24
    rs760292431,2
    C,--195446077(+) ACATTA/-AAAAA 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs794051961,2
    --195446077(+) TACATA/TAAAAA 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs607344051,2
    C--195446078(+) AAAAAA/-GGAGC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs38670681,2
    C--195446107(-) AGTTTG/TCAGGT 1 -- us2k13Minor allele frequency- T:0.17NA 6

    HapMap Linkage Disequilibrium report for MUC20 (195343316 - 195467994 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 29 variations for MUC20
         15/25 CNVs (see all 25): 32549 31137 7399 59125 2491 3472 68544 4366 2064 91820 59126 68548 8439 80084 91822
         2 Indels: 12373 12372
         2 Inversions: 37243 0568

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC20
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MUC20 for disorders           About GeneDecksing

    OMIM gene information: 610360    OMIM disorders: --

    6 diseases for MUC20:    About MalaCards
    iga glomerulonephritis    glomerulonephritis    laryngitis    nephropathy
    pneumonia    prostatitis

    Genetic Association Database (GAD): MUC20
    Human Genome Epidemiology (HuGE) Navigator: MUC20 (2 documents)

    Export disorders for MUC20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MUC20 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MUC20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. (PubMed id 14565953)1, 2, 3 Higuchi T....Nakamura M. (2004)
    2. MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. (PubMed id 15314156)1, 2, 9 Higuchi T.... Nakamura M. (2004)
    3. Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy. (PubMed id 16508246)1, 2 Li G....Wang H. (2006)
    4. [Variable number of tandem repeats polymorphism of MUC20 is associated with the progression of IgA nephropathy] (PubMed id 16029633)1, 4 Li G.S....Wang H.Y. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    8. Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. (PubMed id 18834073)1 Samuels T.L....Johnston N. (2008)
    9. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    10. Mucin gene expression in human male urogenital tract epithelia. (PubMed id 16997931)2 Russo C.L....Gipson I.K. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200958 HGNC: 23282 AceView: MUC20 Ensembl:ENSG00000176945 euGenes: HUgn200958
    ECgene: MUC20 H-InvDB: MUC20

    (According to HUGE)
    About This Section
    HUGE: KIAA1359

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MUC20 Pharmacogenomics, SNPs, Pathways
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MUC20 gene:
    Search GeneIP for patents involving MUC20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MUC20  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MUC20   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC20  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MUC20   OriGene 3'-UTR Clone for MUC20  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC20   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC20  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MUC20   OriGene Custom Protein Services for MUC20  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUC20
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC20
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC20
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC20
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC20
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC20
     GenScript Custom Purified and Recombinant Proteins Services for MUC20 GenScript cDNA clones with any tag delivered in your preferred vector for MUC20
     GenScript Custom Assay Services for MUC20 GenScript Custom Superior Antibodies Services for MUC20
     GenScript Custom overexpressing Cell Line Services for MUC20 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MUC20 promoter
     Search Chromatin IP Primers for MUC20
     RT2 qPCR Primer Assay in human, mouse, rat MUC20
     Search GNC Networks for MUC20
     SABiosciences Custom PCR Arrays for MUC20
     Search Tocris compounds for MUC20
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MUC20 antibodies
     MUC20 proteins
     MUC20 lysates
     Search for Antibodies for MUC20 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MUC20
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MUC20 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MUC20
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC20
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MUC20
     SwitchGear Promoter luciferase reporter plasmids for MUC20
     ThermoFisher Antibodies for MUC20
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUC20
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MUC20 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4