MUC2 Gene
protein-coding GIFtS: 62
GCID: GC11P001064
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|
mucin 2, oligomeric mucus/gel-forming(Previous names: mucin 2, intestinal/tracheal )
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Aliases
for MUC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mucin 2, Oligomeric Mucus/Gel-Forming1 2 | | SMUC2 3 | | Mucin 2, Intestinal/Tracheal1 2 | | MLP2 | | Intestinal Mucin-22 3 | | Mucin-21 | | MUC-22 3 | | Mucin-Like Protein2 |
Export aliases for MUC2 gene to outside databasesPrevious GC identifers: GC11U990088 GC11M000095 GC11P001072 GC11P000897 |
Summaries
for MUC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MUC2:
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by manyepithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protectsthe gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight.The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described,but their full-length nature is not known. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817Function: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought toprovide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Majorconstituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from theinner mucus layer
Gene Wiki entry for MUC2
|
Genomic Views
for MUC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MUC2 gene promoter:
c-Fos Sp1 p53 AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MUC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5MUC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P001064: view genomic region
(about GC identifiers)
Start:
|
1,074,875 bp from pter |
End:
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1,104,419 bp from pter |
Size:
|
29,545 bases |
Orientation:
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plus strand |
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Proteins
for MUC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817 (See
protein sequence)Recommended Name: Mucin-2 precursor Size: 5179 amino acids; 540300 Da
Subunit: Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizesvia its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2;disulfide-linked
Subcellular location: Secreted. Note=In the intestine, secreted into the inner and outer mucus layers (By similarity)
Secondary accessions: Q14878Explore the universe of human proteins at neXtProt for MUC2: NX_Q02817
Post-translational modifications:
O-glycosylated1
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loosenature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense anddevoid of bacteria (By similarity)1
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain.It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q02817
MUC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002448.2
ENSEMBL proteins: ENSP00000415183 ENSP00000351956 ENSP00000354885 ENSP00000331373 Reactome Protein details: Q02817
Human Recombinant Protein Products for MUC2:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MUC2 for ontologies About GeneDecksing
MUC2 Antibody Products:
Assay Products for MUC2: |
Protein
Domains /
Families
for MUC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MUC2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q02817ProtoNet protein and cluster: Q02817 5/6 Blocks protein families (see all 6): IPB001007 von Willebrand factor IPB001846 Von Willebrand factor IPB002400 Growth factor cystine knot superfamily signature IPB002919 Trypsin inhibitor-like IPB006207 Cystine knot
UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domainSimilarity: Contains 1 TIL (trypsin inhibitory-like) domainSimilarity: Contains 2 VWFC domainsSimilarity: Contains 4 VWFD domains |
Function
for MUC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MUC2_HUMAN, Q02817Function: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought toprovide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Majorconstituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from theinner mucus layer Genatlas biochemistry entry for MUC2:mucin 2,intestinal,glycoprotein of membrane,belonging to the secreted mucins cluster,involved in epithelial celldifferentiation,expressed in epithelial ovarian cancer,in normal urothelium and in bladder cancer
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
MUC2 for ontologies About GeneDecksing
Phenotypes:
5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Muc2):
MUC2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Muc2tm1Avel for MUC2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MUC2 (NM_002457) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUC2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC2 |
|
Pathways & Interactions
for MUC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein | | | 2 | Asparagine N-linked glycosylation | | | 3 | Amoebiasis | | | 4 | NTHi-Induced Signaling | | | 5 | Insulin receptor recycling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MUC2
1  GeneGo (Thomson Reuters) Pathway for MUC2
5/8 
Reactome Pathways for MUC2 (see all 8)
2 
Kegg Pathways (Kegg details for MUC2):
MUC2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MUC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/51 Interacting proteins for MUC2 (Q028173 ENSP000004151834) via UniProtKB, MINT, STRING, and/or I2D (see all 51)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
-- | -- | | GO:0006917 | induction of apoptosis |
-- | -- | | GO:0008285 | negative regulation of cell proliferation |
-- | -- | | GO:0016266 | O-glycan processing |
TAS | -- | | GO:0030336 | negative regulation of cell migration |
-- | -- |
MUC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MUC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MUC2 for compounds About GeneDecksing
 Browse Tocris compounds for MUC2
1 DrugBank Compound for MUC2 About this table
10/36 Novoseek chemical compound relationships for MUC2 gene (see all 36) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cesium chloride |
52 |
1 |
19246635 (1) |
| deoxycholic acid |
47.1 |
21 |
17576890 (4), 19014523 (3), 20198339 (2), 15754327 (1) (see all 5) |
| 5-aza-2'deoxycytidine |
43.3 |
7 |
12527922 (1), 9426407 (1), 11368880 (1), 14518264 (1) (see all 5) |
| crcs |
38 |
16 |
11051251 (4), 17951204 (2), 20183800 (2), 12555994 (1) |
| threonine |
35.9 |
15 |
19246635 (6), 9722984 (1), 9195982 (1), 10578046 (1) (see all 5) |
| tunicamycin |
31.5 |
1 |
9451015 (1) |
| butyrate |
29.6 |
19 |
19228118 (8), 12902981 (2), 15308471 (2), 17849419 (1) (see all 6) |
| carbohydrates |
26.2 |
2 |
11160003 (1), 16211224 (1) |
| paraffin |
23 |
5 |
8813954 (1), 19260522 (1), 18992917 (1) |
| pd 98,059 |
20.6 |
4 |
12482999 (1), 18176092 (1), 12077118 (1), 12391274 (1) |
Search CenterWatch for drugs/clinical trials and news about MUC2
|
Transcripts
for MUC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MUC2 gene: NM_002457.2 Unigene Cluster for MUC2: Mucin 2, oligomeric mucus/gel-forming Hs.315 [show with all ESTs]Unigene Representative Sequence: NM_0024574 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441003(uc001lsx.1) ENST00000359061 ENST00000361558 ENST00000333592
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MUC2 (NM_002457) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUC2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC2 |
Additional cDNA sequence: AF257167.1 L21998.1 M22405.1 M86523.1 M94131.1 M94132.1 8 DOTS entries: DT.109216 DT.97835062 DT.95107578 DT.95375324 DT.120693040 DT.87004723 DT.120693023 DT.121004091 24/75 AceView cDNA sequences (see all 75): M94132 BM769184 BX506293 AI991841 CA433774 AI672920 AW849961 CD614857 AI983400 AW000809 BX480159 AI749252 M86523 CA433871 AI246778 BM827111 BM988311 BM768933 AW001371 AI991308 BX950907 AA327452 BM773459 AI346844
GeneLoc Exon Structure
|
Expression
for MUC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MUC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTCGGCCA
About this image
See MUC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MUC2
SOURCE GeneReport for Unigene cluster: Hs.315
UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817Tissue specificity: Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder
SABiosciences Custom PCR Arrays for MUC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MUC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC2 |
Orthologs
for MUC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MUC2 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for MUC2 (if available)
TreeFam Gene Tree for MUC2 (if available) |
Paralogs
for MUC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MUC2 gene
- MUC5AC2 TECTA2 OTOG2 OTOGL2 MUC62 MUC5B2 MUC192 FCGBP2
- VWF2 BMPER2
7 SIMAP similar genes for MUC2 using alignment to 8 protein entries: MUC2_HUMAN (see all proteins):MLP MUC5AC KCP MUC5B MUC19 SSPO
MG1
MUC2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MUC2
PGOHUM00000260286 PGOHUM00000258300
|
Genomic Variants
for MUC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817Polymorphism: The number of repeats is highly polymorphic and varies among different alleles
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MUC2
4 CNVs: 29886 3831 29887 0409
2 Indels: 71223 11529
Human Gene Mutation Database (HGMD): MUC2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC2 |
|
Disorders
/ Diseases
for MUC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MUC2 for disorders About GeneDecksing
OMIM gene information: 158370
OMIM disorders: --
20/87  diseases for MUC2 (see all 87): About MalaCardspseudomyxoma peritonei bile duct cystadenocarcinoma familial adenomatous polyposis ampulla of vater adenocarcinoma
barrett's esophagus ampulla of vater carcinoma bile duct carcinoma allergic rhinitis
inflammatory bowel disease cystadenocarcinoma small intestine adenocarcinoma otitis media
biliary papillomatosis atrophic gastritis mucinous adenocarcinoma carcinoma
ovarian mucinous adenocarcinoma b-cell lymphomas haemophilus influenzae intraepithelial neoplasm
10 diseases from the University of Copenhagen DISEASES database for MUC2:Carcinoma Pseudomyxoma peritonei Adenoma Colorectal cancer
Cholangiocarcinoma Biliary papillomatosis Inflammatory bowel disease Cystic fibrosis
Ampulla of Vater carcinoma Pancreatic cancer 10/92 Novoseek disease relationships for MUC2 gene (see all 92) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma mucinous |
85.3 |
48 |
12493022 (4), 9306958 (4), 15378790 (2), 18487999 (2) (see all 30) |
| metaplasia |
82 |
78 |
17559374 (4), 16545139 (3), 10633292 (3), 10583575 (3) (see all 39) |
| adenocarcinoma |
77 |
107 |
15252308 (3), 18487999 (3), 17991319 (3), 12877727 (3) (see all 61) |
| gastric carcinoma |
74.1 |
67 |
17559374 (4), 15378790 (3), 15737028 (3), 14758553 (3) (see all 36) |
| carcinoma signet ring cell |
71.4 |
1 |
19102008 (1) |
| pseudomyxoma peritonei |
70.6 |
13 |
12218214 (6), 12163380 (6) |
| carcinoma |
70.3 |
99 |
11893907 (4), 15272531 (4), 10227723 (3), 11420467 (3) (see all 56) |
| adenocarcinoma tubular |
65.8 |
4 |
15378790 (1), 19102008 (1), 19680592 (1) |
| adenoma |
64.6 |
49 |
10424888 (4), 9215126 (3), 12820724 (3), 12210083 (2) (see all 26) |
| barrett esophagus |
63.9 |
8 |
16259110 (1), 16995451 (1), 16336609 (1), 12152167 (1) (see all 8) |
Genetic Association Database (GAD): MUC2
Human Genome Epidemiology (HuGE) Navigator: MUC2 (9 documents)
Export disorders for MUC2 gene to outside databases
|
Publications
for MUC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MUC2 gene, integrated from 9 sources (see all 624):
(articles sorted by number of sources associating them with MUC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5. (PubMed id 1550588)1, 2, 9 Xu G.... Forstner J. (1992)
- Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. (PubMed id 8300571)1, 2, 9 Gum J.R. Jr.... Kim Y.S. (1994)
- The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. (PubMed id 19359471)1, 2 Park S.-W.... Erle D.J. (2009)
- Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. (PubMed id 19432394)1, 2 Johansson M.E.V.... Hansson G.C. (2009)
- The complete genomic organization of the human MUC6 and MUC2 mucin genes. (PubMed id 15081123)1, 3 Rousseau K....Toribara N.W. (2004)
- An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway. (PubMed id 12582180)1, 2 Lidell M.E....Hansson G.C. (2003)
- In vivo glycosylation of mucin tandem repeats. (PubMed id 11445551)1, 2 Silverman H.S....Harris A. (2001)
- Polymorphism of human mucin genes in chest disease: possible significance of MUC2. (PubMed id 11062147)1, 4 Vinall L.E....Swallow D.M. (2000)
- The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region. (PubMed id 1400449)1, 2 Gum J.R. Jr....Kim Y.S. (1992)
- MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism. (PubMed id 1885763)1, 2 Toribara N.W.... Kim Y.S. (1991)
|
External Searches for MUC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MUC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MUC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MUC2 gene:
Search GeneIP for patents involving MUC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MUC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for MUC2 | | OriGene shRNA RFP for MUC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MUC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MUC2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MUC2 | | OriGene Custom Protein Services for MUC2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC2 |
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| | | | Search Tocris compounds for MUC2 |
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 | | | MUC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC2 |
|  |  |  |  | | | | ThermoFisher Antibodies for MUC2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC2 |
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