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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MUC2 Gene

protein-coding   GIFtS: 61
GCID: GC11P001064

Mucin 2, Oligomeric Mucus/Gel-Forming

(Previous names: mucin 2, intestinal/tracheal)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mucin 2, Oligomeric Mucus/Gel-Forming1 2     SMUC2 3
Mucin 2, Intestinal/Tracheal1 2     MLP2
Intestinal Mucin-22 3     mucin-22
MUC-22 3     Mucin-Like Protein2

External Ids:    HGNC: 75121   Entrez Gene: 45832   Ensembl: ENSG000001987887   OMIM: 1583705   UniProtKB: Q028173   

Export aliases for MUC2 gene to outside databases

Previous GC identifers: GC11U990088 GC11M000095 GC11P001072 GC11P000897


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MUC2 Gene:
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by
many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that
protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side
chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline
that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this
gene have been described, but their full-length nature is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for MUC2 Gene: 
MUC2 (mucin 2, oligomeric mucus/gel-forming) is a protein-coding gene. Diseases associated with MUC2 include cholangiocarcinoma, and pseudomyxoma peritonei, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817
Function: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to
provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major
constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from
the inner mucus layer

Gene Wiki entry for MUC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MUC2 gene promoter:
         c-Fos   Sp1   p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMUC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MUC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

MUC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001064:  view genomic region     (about GC identifiers)

Start:
1,074,875 bp from pter      End:
1,104,419 bp from pter
Size:
29,545 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817 (See protein sequence)
Recommended Name: Mucin-2 precursor  
Size: 5179 amino acids; 540300 Da
Subunit: Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and
polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with
AGR2; disulfide-linked
Subcellular location: Secreted. Note=In the intestine, secreted into the inner and outer mucus layers (By
similarity)
Secondary accessions: Q14878

Explore the universe of human proteins at neXtProt for MUC2: NX_Q02817

Explore proteomics data for MUC2 at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated
  • UniProtKB: May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and
    loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is
    dense and devoid of bacteria (By similarity)
  • UniProtKB: At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD
    domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02817

  • MUC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MUC2 Protein Expression
    REFSEQ proteins: NP_002448.2  
    ENSEMBL proteins: 
     ENSP00000415183   ENSP00000351956   ENSP00000354885   ENSP00000331373  
    Reactome Protein details: Q02817
    Human Recombinant Protein Products for MUC2: 
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    Cloud-Clone Corp. Proteins for MUC2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005796Golgi lumen TAS--
    GO:0070702inner mucus layer ISS--
    GO:0070703outer mucus layer ISS--

    MUC2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MUC: Mucins

    5/7 InterPro protein domains (see all 7):
     IPR014853 Unchr_dom_Cys-rich
     IPR006207 Cys_knot_C
     IPR006552 VWC_out
     IPR002919 TIL_dom
     IPR025155 WxxW_domain

    Graphical View of Domain Structure for InterPro Entry Q02817

    ProtoNet protein and cluster: Q02817

    5/6 Blocks protein domains (see all 6):
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002400 Growth factor cystine knot superfamily signature
    IPB002919 Trypsin inhibitor-like
    IPB006207 Cystine knot


    UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 TIL (trypsin inhibitory-like) domain
    Similarity: Contains 2 VWFC domains
    Similarity: Contains 4 VWFD domains


    MUC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC2_HUMAN, Q02817
    Function: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to
    provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major
    constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from
    the inner mucus layer

         Genatlas biochemistry entry for MUC2:
    mucin 2,intestinal,glycoprotein of membrane,belonging to the secreted mucins cluster,involved in epithelial cell
    differentiation,expressed in epithelial ovarian cancer,in normal urothelium and in bladder cancer

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19359471
    GO:0030414peptidase inhibitor activity ----
         
    MUC2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Muc2):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  tumorigenesis 

    MUC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Muc2tm1Avel for MUC2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MUC2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MUC2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Termination of O-glycan biosynthesis0.41
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Insulin receptor recycling
    Vibrio cholerae infection0.41
    4Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    5Amoebiasis
    Amoebiasis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MUC2
        NTHi-Induced Signaling

    1 GeneGo (Thomson Reuters) Pathway for MUC2
        Mucin expression in CF via TLRs, EGFR signaling pathways

    4        Reactome Pathways for MUC2
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Termination of O-glycan biosynthesis


    2         Kegg Pathways  (Kegg details for MUC2):
        Vibrio cholerae infection
    Amoebiasis


    MUC2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MUC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for MUC2 (Q028173 ENSP000004151834) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    GALNT12Q8IXK23, ENSP000003641504I2D: score=1 STRING: ENSP00000364150
    PLEKHM1Q9Y4G23, ENSP000003899134I2D: score=1 STRING: ENSP00000389913
    GALNT14Q96FL93, ENSP000002889884I2D: score=2 STRING: ENSP00000288988
    MAP4K5Q9Y4K43I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0008285negative regulation of cell proliferation ----
    GO:0016266O-glycan processing TAS--
    GO:0030336negative regulation of cell migration ----
    GO:0043687post-translational protein modification TAS--

    MUC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MUC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MUC2

    1 DrugBank Compound for MUC2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pranlukast-- 103177-37-3targetother/unknown17223000 15475658

    10/36 Novoseek inferred chemical compound relationships for MUC2 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cesium chloride 52 1 19246635 (1)
    deoxycholic acid 47.1 21 17576890 (4), 19014523 (3), 20198339 (2), 15754327 (1) (see all 5)
    5-aza-2'deoxycytidine 43.3 7 12527922 (1), 9426407 (1), 11368880 (1), 14518264 (1) (see all 5)
    crcs 38 16 11051251 (4), 17951204 (2), 20183800 (2), 12555994 (1)
    threonine 35.9 15 19246635 (6), 9722984 (1), 9195982 (1), 10578046 (1) (see all 5)
    tunicamycin 31.5 1 9451015 (1)
    butyrate 29.6 19 19228118 (8), 12902981 (2), 15308471 (2), 17849419 (1) (see all 6)
    carbohydrates 26.2 2 11160003 (1), 16211224 (1)
    paraffin 23 5 8813954 (1), 19260522 (1), 18992917 (1)
    pd 98,059 20.6 4 12482999 (1), 18176092 (1), 12077118 (1), 12391274 (1)

    Search CenterWatch for drugs/clinical trials and news about MUC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MUC2 gene: 
    NM_002457.2  

    Unigene Cluster for MUC2:

    Mucin 2, oligomeric mucus/gel-forming
    Hs.315  [show with all ESTs]
    Unigene Representative Sequence: NM_002457
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441003(uc001lsx.1) ENST00000359061 ENST00000361558 ENST00000333592

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF257167.1 L21998.1 M22405.1 M86523.1 M94131.1 M94132.1 

    8 DOTS entries:

    DT.109216  DT.97835062  DT.95107578  DT.95375324  DT.120693040  DT.87004723  DT.120693023  DT.121004091 

    24/75 AceView cDNA sequences (see all 75):

    M94132 BM769184 M86523 AI732350 BX480159 AW849961 AW000809 CA433774 
    BX505925 BX950907 BM773459 AI991308 AI246778 AW001371 BM988311 AI346844 
    AI991265 CD614857 AI677743 AI749252 AA327452 AW604941 BQ083982 BM768933 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MUC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTCGGCCA
    MUC2 Expression
    About this image


    See MUC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MUC2

    SOURCE GeneReport for Unigene cluster: Hs.315

    UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817
    Tissue specificity: Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MUC2 gene from 5/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Muc25 mucin 2   --   7 (87.10 cM) 141744616 
    chicken
    (Gallus gallus)
    Aves LOC1008571281 mucin-2-like 57.85(n)
    55.95(a)
      100857128  XM_003641323.1  XP_003641371.1 
    lizard
    (Anolis carolinensis)
    Reptilia MUC26
    --
    Uncharacterized protein
    66(a)
    32(a)
    1 ↔ many
    1 ↔ many
    1(72326061-72343344)
    1(72270738-72303048)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5575911 mucin-5AC-like 52.32(n)
    46.75(a)
      557591  XM_680677.5  XP_685769.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hml3 defense response sugar binding 28(a)   70C4   --


    ENSEMBL Gene Tree for MUC2 (if available)
    TreeFam Gene Tree for MUC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MUC2 gene
    6 SIMAP similar genes for MUC2 using alignment to 8 protein entries:     MUC2_HUMAN (see all proteins):
    MLP    MUC5AC    KCP    MUC5B    MUC19    SSPO

    MUC2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MUC2
    PGOHUM00000260286 PGOHUM00000258300


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MUC2_HUMAN, Q02817
    Polymorphism: The number of repeats is highly polymorphic and varies among different alleles


    10/11 SNPs in MUC2 are shown (see all 11)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0565844
    ----see VAR_0565842 G S mis40--------
    VAR_0614874
    ----see VAR_0614872 P H mis40--------
    VAR_0595364
    ----see VAR_0595362 Q L mis40--------
    VAR_0595354
    ----see VAR_0595352 T S mis40--------
    VAR_0565834
    ----see VAR_0565832 V M mis40--------
    VAR_0595324
    ----see VAR_0595322 P L mis40--------
    VAR_0595374
    ----see VAR_0595372 Q P mis40--------
    VAR_0595314
    ----see VAR_0595312 S R mis40--------
    VAR_0595344
    ----see VAR_0595342 T P mis40--------
    VAR_0565824
    ----see VAR_0565822 L P mis40--------

    HapMap Linkage Disequilibrium report for MUC2 (1074875 - 1104419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/36 variations for MUC2 (see all 36):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv145e201CNV Deletion23290073
    esv992502CNV Deletion20482838
    dgv184e199CNV Deletion23128226
    esv2743878CNV Deletion23290073
    esv2743893CNV Deletion23290073
    esv2743891CNV Deletion23290073
    esv2743889CNV Deletion23290073
    esv2743894CNV Deletion23290073
    esv2743888CNV Deletion23290073
    dgv146e201CNV Deletion23290073


    Human Gene Mutation Database (HGMD): MUC2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MUC2
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 158370    OMIM disorders: --

    20/75 diseases for MUC2 (see all 75):    About MalaCards
    cholangiocarcinoma    pseudomyxoma peritonei    mucinous adenocarcinoma    gallbladder adenocarcinoma
    biliary papillomatosis    bile duct cystadenocarcinoma    colon adenocarcinoma    mucoepidermoid carcinoma
    bile duct carcinoma    epstein-barr virus-associated gastric carcinoma    chronic cholangitis    ovarian mucinous adenocarcinoma
    ampulla of vater carcinoma    ampulla of vater adenocarcinoma    small intestine adenocarcinoma    pancreatic ductal carcinoma
    gallbladder cancer    cystadenocarcinoma    barrett's esophagus    cystic teratoma

    10 diseases from the University of Copenhagen DISEASES database for MUC2:
    Carcinoma     Pseudomyxoma peritonei     Adenoma     Colorectal cancer
    Cholangiocarcinoma     Biliary papillomatosis     Inflammatory bowel disease     Cystic fibrosis
    Ampulla of Vater carcinoma     Pancreatic cancer

    MUC2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/92 Novoseek inferred disease relationships for MUC2 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma mucinous 85.3 48 12493022 (4), 9306958 (4), 15378790 (2), 18487999 (2) (see all 30)
    metaplasia 82 78 17559374 (4), 16545139 (3), 10633292 (3), 10583575 (3) (see all 39)
    adenocarcinoma 77 107 15252308 (3), 18487999 (3), 17991319 (3), 12877727 (3) (see all 61)
    gastric carcinoma 74.1 67 17559374 (4), 15378790 (3), 15737028 (3), 14758553 (3) (see all 36)
    carcinoma signet ring cell 71.4 1 19102008 (1)
    pseudomyxoma peritonei 70.6 13 12218214 (6), 12163380 (6)
    carcinoma 70.3 99 11893907 (4), 15272531 (4), 10227723 (3), 11420467 (3) (see all 56)
    adenocarcinoma tubular 65.8 4 15378790 (1), 19102008 (1), 19680592 (1)
    adenoma 64.6 49 10424888 (4), 9215126 (3), 12820724 (3), 12210083 (2) (see all 26)
    barrett esophagus 63.9 8 16259110 (1), 16995451 (1), 16336609 (1), 12152167 (1) (see all 8)

    Genetic Association Database (GAD): MUC2
    Human Genome Epidemiology (HuGE) Navigator: MUC2 (9 documents)

    Export disorders for MUC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MUC2 gene, integrated from 9 sources (see all 633):
    (articles sorted by number of sources associating them with MUC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5. (PubMed id 1550588)1, 2, 9 Xu G.... Forstner J. (1992)
    2. Mucin gene polymorphisms in otitis media patients. (PubMed id 19718741)1, 4, 9 Ubell M.L....Kerschner J.E. (2010)
    3. Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. (PubMed id 8300571)1, 2, 9 Gum J.R. Jr.... Kim Y.S. (1994)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    6. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. (PubMed id 19359471)1, 2 Park S.-W.... Erle D.J. (2009)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    8. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. (PubMed id 19432394)1, 2 Johansson M.E.V.... Hansson G.C. (2009)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    10. Rare exonic minisatellite alleles in MUC2 influence susceptibility to gastric carcinoma. (PubMed id 18000536)1, 4 Jeong Y.H....Leem S.H. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4583 HGNC: 7512 AceView: MUC2.1 Ensembl:ENSG00000198788 euGenes: HUgn4583
    ECgene: MUC2 Kegg: 4583 H-InvDB: MUC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MUC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MUC2 Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MUC2 gene:
    Search GeneIP for patents involving MUC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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