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Aliases for MUC2 Gene

Aliases for MUC2 Gene

  • Mucin 2, Oligomeric Mucus/Gel-Forming 2 3
  • Mucin 2, Intestinal/Tracheal 2 3
  • Intestinal Mucin-2 3 4
  • MUC-2 3 4
  • SMUC 3 4
  • Mucin-Like Protein 3
  • Mucin-2 3
  • MLP 3

External Ids for MUC2 Gene

Summaries for MUC2 Gene

Entrez Gene Summary for MUC2 Gene

  • This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for MUC2 Gene

MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC2 include pancreatic ductal carcinoma and pseudomyxoma peritonei. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. An important paralog of this gene is OTOGL.

UniProtKB/Swiss-Prot for MUC2 Gene

  • Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Gene Wiki entry for MUC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC2 Gene

Genomics for MUC2 Gene

Genomic Location for MUC2 Gene

Start:
1,074,875 bp from pter
End:
1,110,511 bp from pter
Size:
35,637 bases
Orientation:
Plus strand

Genomic View for MUC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC2 Gene

Regulatory Elements for MUC2 Gene

Proteins for MUC2 Gene

  • Protein details for MUC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02817-MUC2_HUMAN
    Recommended name:
    Mucin-2
    Protein Accession:
    Q02817
    Secondary Accessions:
    • Q14878

    Protein attributes for MUC2 Gene

    Size:
    5179 amino acids
    Molecular mass:
    540300 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked.

neXtProt entry for MUC2 Gene

Proteomics data for MUC2 Gene at MOPED

Post-translational modifications for MUC2 Gene

  • At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway
  • May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
  • O-glycosylated
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn163, Asn423, Asn670, Asn770, Asn894, Asn1139, Asn1154, Asn1215, Asn1230, Asn1246, Asn1787, Asn1820, Asn4339, Asn4351, Asn4362, Asn4373, Asn4422, Asn4438, Asn4502, Asn4616, Asn4627, Asn4752, Asn4787, Asn4881, Asn4888, Asn4955, Asn4970, Asn5019, Asn5038, and Asn5069

Other Protein References for MUC2 Gene

Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC2 Gene

Domains for MUC2 Gene

Gene Families for MUC2 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

Q02817

UniProtKB/Swiss-Prot:

MUC2_HUMAN
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.:
    • Q02817
  • Contains 1 TIL (trypsin inhibitory-like) domain.:
    • Q02817
  • Contains 2 VWFC domains.:
    • Q02817
  • Contains 4 VWFD domains.:
    • Q02817
genes like me logo Genes that share domains with MUC2: view

Function for MUC2 Gene

Molecular function for MUC2 Gene

GENATLAS Biochemistry: mucin 2,intestinal,glycoprotein of membrane,belonging to the secreted mucins cluster,involved in epithelial cell differentiation,expressed in epithelial ovarian cancer,in normal urothelium and in bladder cancer
UniProtKB/Swiss-Prot Function: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Gene Ontology (GO) - Molecular Function for MUC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19359471
genes like me logo Genes that share ontologies with MUC2: view
genes like me logo Genes that share phenotypes with MUC2: view

Animal Models for MUC2 Gene

MGI Knock Outs for MUC2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MUC2 Gene

Localization for MUC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC2 Gene

Secreted. Note=In the intestine, secreted into the inner and outer mucus layers. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC2 Gene COMPARTMENTS Subcellular localization image for MUC2 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
endoplasmic reticulum 2
nucleus 2
cytoskeleton 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MUC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0070702 inner mucus layer ISS --
GO:0070703 outer mucus layer ISS --
genes like me logo Genes that share ontologies with MUC2: view

Pathways for MUC2 Gene

genes like me logo Genes that share pathways with MUC2: view

Pathways by source for MUC2 Gene

Interacting Proteins for MUC2 Gene

Selected Interacting proteins: Q02817-MUC2_HUMAN for MUC2 Gene via I2D

Gene Ontology (GO) - Biological Process for MUC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0030277 maintenance of gastrointestinal epithelium IMP 17058067
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC2: view

Compounds for MUC2 Gene

(1) Drugbank Compounds for MUC2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pranlukast
103177-37-3 target other/unknown

(36) Novoseek inferred chemical compound relationships for MUC2 Gene

Compound -log(P) Hits PubMed IDs
cesium chloride 52 1
deoxycholic acid 47.1 11
5-aza-2deoxycytidine 43.3 5
crcs 38 9
threonine 35.9 10
genes like me logo Genes that share compounds with MUC2: view

Transcripts for MUC2 Gene

mRNA/cDNA for MUC2 Gene

Unigene Clusters for MUC2 Gene

Mucin 2, oligomeric mucus/gel-forming:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC2 Gene

No ASD Table

Relevant External Links for MUC2 Gene

GeneLoc Exon Structure for
MUC2
ECgene alternative splicing isoforms for
MUC2

Expression for MUC2 Gene

mRNA expression in normal human tissues for MUC2 Gene

mRNA differential expression in normal tissues according to GTEx for MUC2 Gene

This gene is overexpressed in Colon - Transverse (31.2) and Small Intestine - Terminal Ileum (19.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MUC2 Gene

SOURCE GeneReport for Unigene cluster for MUC2 Gene Hs.315

mRNA Expression by UniProt/SwissProt for MUC2 Gene

Q02817-MUC2_HUMAN
Tissue specificity: Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder
genes like me logo Genes that share expressions with MUC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MUC2 Gene

Orthologs for MUC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MUC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102154704 35
  • 83.47 (n)
  • 81.2 (a)
MUC2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Muc2 35
  • 78.7 (n)
  • 76.19 (a)
Muc2 16
oppossum
(Monodelphis domestica)
Mammalia MUC2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUC2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MUC2 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MUC2 (1 of 2) 36
  • 46 (a)
OneToMany
MUC2 (2 of 2) 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Hml 36
  • 15 (a)
OneToMany
Hml 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for MUC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUC2 Gene

ENSEMBL:
Gene Tree for MUC2 (if available)
TreeFam:
Gene Tree for MUC2 (if available)

Paralogs for MUC2 Gene

Paralogs for MUC2 Gene

Selected SIMAP similar genes for MUC2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for MUC2 Gene

genes like me logo Genes that share paralogs with MUC2: view

Variants for MUC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC2 Gene

Q02817-MUC2_HUMAN
The number of repeats is highly polymorphic and varies among different alleles

Sequence variations from dbSNP and Humsavar for MUC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_056582 -
VAR_056583 -
VAR_056584 -
VAR_059531 -
VAR_059532 -

Structural Variations from Database of Genomic Variants (DGV) for MUC2 Gene

Variant ID Type Subtype PubMed ID
nsv469923 CNV Loss 18288195
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226
essv22587 CNV CNV 17122850
nsv896643 CNV Loss 21882294
nsv896644 CNV Loss 21882294
nsv832045 CNV Gain+Loss 17160897
dgv959n71 CNV Loss 21882294
nsv896651 CNV Loss 21882294
dgv960n71 CNV Loss 21882294
nsv60 CNV Insertion 15895083
nsv7638 CNV Insertion 18451855
nsv896653 CNV Gain+Loss 21882294
dgv961n71 CNV Loss 21882294
dgv962n71 CNV Loss 21882294
dgv963n71 CNV Loss 21882294
nsv518205 CNV Loss 19592680
esv2743888 CNV Deletion 23290073
esv2743889 CNV Deletion 23290073
esv1678011 CNV Insertion 17803354
nsv511482 CNV Loss 21212237
esv1010440 CNV Insertion 20482838
nsv512200 CNV Loss 21212237
dgv145e201 CNV Deletion 23290073
dgv184e199 CNV Deletion 23128226
nsv39410 CNV Loss 16902084
esv22815 CNV Gain+Loss 19812545
esv2743891 CNV Deletion 23290073
esv992502 CNV Deletion 20482838
esv2743893 CNV Deletion 23290073
esv2743894 CNV Deletion 23290073
dgv146e201 CNV Deletion 23290073
nsv511471 CNV Loss 21212237
nsv825690 CNV Loss 20364138
esv1217413 CNV Deletion 17803354
esv1343845 CNV Insertion 17803354

Relevant External Links for MUC2 Gene

HapMap Linkage Disequilibrium report
MUC2
Human Gene Mutation Database (HGMD)
MUC2

Disorders for MUC2 Gene

(92) Novoseek inferred disease relationships for MUC2 Gene

Disease -log(P) Hits PubMed IDs
carcinoma mucinous 85.3 41
metaplasia 82 58
adenocarcinoma 77 83
gastric carcinoma 74.1 57
carcinoma signet ring cell 71.4 1

Relevant External Links for MUC2

Genetic Association Database (GAD)
MUC2
Human Genome Epidemiology (HuGE) Navigator
MUC2
genes like me logo Genes that share disorders with MUC2: view

No data available for UniProtKB/Swiss-Prot for MUC2 Gene

Publications for MUC2 Gene

  1. Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5. (PMID: 1550588) Xu G. … Forstner J. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  2. Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus. (PMID: 9065467) Velcich A. … Augenlicht L. (J. Biol. Chem. 1997) 3 23
  3. Identification and characterization of the MUC2 (human intestinal mucin) gene 5'-flanking region: promoter activity in cultured cells. (PMID: 9224654) Gum J.R. … Kim Y.S. (Biochem. J. 1997) 3 23
  4. Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B. (PMID: 12077118) Lee H.W. … Kim Y.S. (J. Biol. Chem. 2002) 3 23
  5. De novo expression of the Muc2 gene in pancreas carcinoma cells is triggered by promoter demethylation. (PMID: 11893907) Siedow A. … Hanski C. (Tumour Biol. 2002) 3 23

Products for MUC2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MUC2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MUC2
    • Block miRNA regulation of MUC2 using miScript Target Protectors

    Sources for MUC2 Gene

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