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Aliases for MUC19 Gene

Aliases for MUC19 Gene

  • Mucin 19, Oligomeric 2 3 5
  • MUC-19 3 4
  • EC 4.2.3.4 63
  • EC 2.7.7.6 63
  • EC 4.2.3.5 63

External Ids for MUC19 Gene

Previous GeneCards Identifiers for MUC19 Gene

  • GC12P040574
  • GC12P039144
  • GC12P039222
  • GC12P040788
  • GC12P037953

Summaries for MUC19 Gene

Entrez Gene Summary for MUC19 Gene

  • This gene encodes a member of the gel-forming mucin protein family. Mucin family members are glycoproteins that have tandem repeats which are extensively O-glycosylated. The structural features of mucin proteins are responsible for the gel-like properties of mucus. The encoded protein may be involved in disruption of the ocular surface in Sjogren syndrome. [provided by RefSeq, Apr 2014]

GeneCards Summary for MUC19 Gene

MUC19 (Mucin 19, Oligomeric) is a Protein Coding gene. Diseases associated with MUC19 include sjogren's syndrome. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for MUC19 Gene

  • May function in ocular mucus homeostasis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC19 Gene

Genomics for MUC19 Gene

Regulatory Elements for MUC19 Gene

Transcription factor binding sites by QIAGEN in the MUC19 gene promoter:

Genomic Location for MUC19 Gene

Chromosome:
12
Start:
40,393,394 bp from pter
End:
40,570,832 bp from pter
Size:
177,439 bases
Orientation:
Plus strand

Genomic View for MUC19 Gene

Genes around MUC19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC19 Gene

Proteins for MUC19 Gene

  • Protein details for MUC19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5P9-MUC19_HUMAN
    Recommended name:
    Mucin-19
    Protein Accession:
    Q7Z5P9
    Secondary Accessions:
    • Q8NA85

    Protein attributes for MUC19 Gene

    Size:
    6254 amino acids
    Molecular mass:
    598155 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04041.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC19 Gene

Proteomics data for MUC19 Gene at MOPED

Selected DME Specific Peptides for MUC19 Gene

Post-translational modifications for MUC19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MUC19 Gene

REFSEQ proteins:

Domains & Families for MUC19 Gene

Gene Families for MUC19 Gene

HGNC:

Suggested Antigen Peptide Sequences for MUC19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5P9

UniProtKB/Swiss-Prot:

MUC19_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 2 VWFC domains.
  • Contains 3 VWFD domains.
genes like me logo Genes that share domains with MUC19: view

Function for MUC19 Gene

Molecular function for MUC19 Gene

UniProtKB/Swiss-Prot Function:
May function in ocular mucus homeostasis.
UniProtKB/Swiss-Prot Induction:
Down-regulated in Sjoegren syndrome patients (at protein level).

Enzyme Numbers (IUBMB) for MUC19 Gene

Phenotypes for MUC19 Gene

genes like me logo Genes that share phenotypes with MUC19: view

miRNA for MUC19 Gene

miRTarBase miRNAs that target MUC19

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC19 Gene

Localization for MUC19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC19 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC19 Gene COMPARTMENTS Subcellular localization image for MUC19 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MUC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MUC19: view

Drugs & Compounds for MUC19 Gene

No Compound Related Data Available

Transcripts for MUC19 Gene

mRNA/cDNA for MUC19 Gene

(1) REFSEQ mRNAs :
(22) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC19 Gene

Mucin 19, oligomeric:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC19 Gene

No ASD Table

Relevant External Links for MUC19 Gene

GeneLoc Exon Structure for
MUC19
ECgene alternative splicing isoforms for
MUC19

Expression for MUC19 Gene

mRNA expression in normal human tissues for MUC19 Gene

mRNA differential expression in normal tissues according to GTEx for MUC19 Gene

This gene is overexpressed in Minor Salivary Gland (x35.1) and Testis (x11.9).

Protein differential expression in normal tissues from HIPED for MUC19 Gene

This gene is overexpressed in Breast (52.8) and Stomach (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUC19 Gene



SOURCE GeneReport for Unigene cluster for MUC19 Gene Hs.632712

mRNA Expression by UniProt/SwissProt for MUC19 Gene

Q7Z5P9-MUC19_HUMAN
Tissue specificity: Expressed corneal epithelial cells, conjunctival goblet and epithelial cells and lacrimal gland cells (at protein level). Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expressed by middle ear epithelial cells.
genes like me logo Genes that share expression patterns with MUC19: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for MUC19 Gene

Orthologs for MUC19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MUC19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC19 35
  • 96.79 (n)
  • 94.11 (a)
MUC19 36
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MUC19 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MUC19 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Muc19 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUC19 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 9 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MUC19 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MUC19 36
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hml 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
Species with no ortholog for MUC19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUC19 Gene

ENSEMBL:
Gene Tree for MUC19 (if available)
TreeFam:
Gene Tree for MUC19 (if available)

Paralogs for MUC19 Gene

Pseudogenes.org Pseudogenes for MUC19 Gene

genes like me logo Genes that share paralogs with MUC19: view

No data available for Paralogs for MUC19 Gene

Variants for MUC19 Gene

Sequence variations from dbSNP and Humsavar for MUC19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_056617 -
VAR_056618 -
VAR_056619 -
VAR_056620 -
VAR_056621 -

Variation tolerance for MUC19 Gene

Gene Damage Index Score: 39.90; 99.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC19 Gene

HapMap Linkage Disequilibrium report
MUC19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC19 Gene

Disorders for MUC19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MUC19 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MUC19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC19

Genetic Association Database (GAD)
MUC19
Human Genome Epidemiology (HuGE) Navigator
MUC19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC19
genes like me logo Genes that share disorders with MUC19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC19 Gene

Publications for MUC19 Gene

  1. Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. (PMID: 12882755) Chen Y. … Wu R. (Am. J. Respir. Cell Mol. Biol. 2004) 2 3 4 67
  2. Salivary mucin 19 glycoproteins: innate immune functions in Streptococcus mutans-induced caries in mice and evidence for expression in human saliva. (PMID: 25512380) Culp D.J. … Cuadra-Saenz G. (J. Biol. Chem. 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Genome-wide association study signal at the 12q12 locus for Crohn's disease may represent associations with the MUC19 gene. (PMID: 23619718) Kumar V. … Levy E. (Inflamm. Bowel Dis. 2013) 3
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3

Products for MUC19 Gene

Sources for MUC19 Gene

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