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Aliases for MUC19 Gene

Aliases for MUC19 Gene

  • Mucin 19, Oligomeric 2 3
  • MUC-19 3 4
  • EC 63
  • EC 63
  • EC 63

External Ids for MUC19 Gene

Previous GeneCards Identifiers for MUC19 Gene

  • GC12P040574
  • GC12P039144
  • GC12P039222
  • GC12P040788
  • GC12P037953

Summaries for MUC19 Gene

Entrez Gene Summary for MUC19 Gene

  • This gene encodes a member of the gel-forming mucin protein family. Mucin family members are glycoproteins that have tandem repeats which are extensively O-glycosylated. The structural features of mucin proteins are responsible for the gel-like properties of mucus. The encoded protein may be involved in disruption of the ocular surface in Sjogren syndrome. [provided by RefSeq, Apr 2014]

GeneCards Summary for MUC19 Gene

MUC19 (Mucin 19, Oligomeric) is a Protein Coding gene. Diseases associated with MUC19 include sjogren's syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and O-linked glycosylation. An important paralog of this gene is OTOGL.

UniProtKB/Swiss-Prot for MUC19 Gene

  • May function in ocular mucus homeostasis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC19 Gene

Genomics for MUC19 Gene

Regulatory Elements for MUC19 Gene

Transcription factor binding sites by QIAGEN in the MUC19 gene promoter:

Genomic Location for MUC19 Gene

40,393,394 bp from pter
40,570,832 bp from pter
177,439 bases
Plus strand

Genomic View for MUC19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MUC19 Gene

Proteins for MUC19 Gene

  • Protein details for MUC19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8NA85

    Protein attributes for MUC19 Gene

    6254 amino acids
    Molecular mass:
    598155 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04041.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC19 Gene


neXtProt entry for MUC19 Gene

Proteomics data for MUC19 Gene at MOPED

Selected DME Specific Peptides for MUC19 Gene

Post-translational modifications for MUC19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MUC19 Gene

REFSEQ proteins:

Domains & Families for MUC19 Gene

Gene Families for MUC19 Gene


Suggested Antigen Peptide Sequences for MUC19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 2 VWFC domains.
  • Contains 3 VWFD domains.
genes like me logo Genes that share domains with MUC19: view

Function for MUC19 Gene

Molecular function for MUC19 Gene

UniProtKB/Swiss-Prot Function:
May function in ocular mucus homeostasis.
UniProtKB/Swiss-Prot Induction:
Down-regulated in Sjoegren syndrome patients (at protein level).

Enzyme Numbers (IUBMB) for MUC19 Gene

Phenotypes for MUC19 Gene

genes like me logo Genes that share phenotypes with MUC19: view

miRNA for MUC19 Gene

miRTarBase miRNAs that target MUC19

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC19 Gene

Localization for MUC19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC19 Gene


Subcellular locations from

Jensen Localization Image for MUC19 Gene COMPARTMENTS Subcellular localization image for MUC19 gene
Compartment Confidence
extracellular 5
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for MUC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MUC19: view

Pathways & Interactions for MUC19 Gene

genes like me logo Genes that share pathways with MUC19: view

Interacting Proteins for MUC19 Gene

Gene Ontology (GO) - Biological Process for MUC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC19: view

No data available for SIGNOR curated interactions for MUC19 Gene

Drugs & Compounds for MUC19 Gene

No Compound Related Data Available

Transcripts for MUC19 Gene

mRNA/cDNA for MUC19 Gene

(1) REFSEQ mRNAs :
(22) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC19 Gene

Mucin 19, oligomeric:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC19 Gene

No ASD Table

Relevant External Links for MUC19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC19 Gene

mRNA expression in normal human tissues for MUC19 Gene

mRNA differential expression in normal tissues according to GTEx for MUC19 Gene

This gene is overexpressed in Minor Salivary Gland (x35.1) and Testis (x11.9).

Protein differential expression in normal tissues from HIPED for MUC19 Gene

This gene is overexpressed in Breast (52.8) and Stomach (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUC19 Gene

SOURCE GeneReport for Unigene cluster for MUC19 Gene Hs.632712

mRNA Expression by UniProt/SwissProt for MUC19 Gene

Tissue specificity: Expressed corneal epithelial cells, conjunctival goblet and epithelial cells and lacrimal gland cells (at protein level). Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expressed by middle ear epithelial cells.
genes like me logo Genes that share expression patterns with MUC19: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for MUC19 Gene

Orthologs for MUC19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MUC19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MUC19 35
  • 96.79 (n)
  • 94.11 (a)
MUC19 36
  • 85 (a)
(Bos Taurus)
Mammalia MUC19 36
  • 75 (a)
(Canis familiaris)
Mammalia MUC19 36
  • 71 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
(Mus musculus)
Mammalia Muc19 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia MUC19 36
  • 74 (a)
(Gallus gallus)
Aves -- 36
  • 9 (a)
(Anolis carolinensis)
Reptilia MUC19 36
  • 46 (a)
(Danio rerio)
Actinopterygii MUC19 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hml 36
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for MUC19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUC19 Gene

Gene Tree for MUC19 (if available)
Gene Tree for MUC19 (if available)

Paralogs for MUC19 Gene

Paralogs for MUC19 Gene Pseudogenes for MUC19 Gene

genes like me logo Genes that share paralogs with MUC19: view

Variants for MUC19 Gene

Sequence variations from dbSNP and Humsavar for MUC19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs719227 -- 40,501,224(-) TCCCT(A/G)CCAAC intron-variant
rs719228 -- 40,501,162(-) CCACC(A/C)CAGTC reference, missense
rs985820 -- 40,457,735(+) CTAAA(A/G)GGGCA intron-variant
rs1035811 -- 40,458,596(+) aaata(C/T)aaatt intron-variant
rs1116144 -- 40,459,501(+) TTTTT(A/G)TACCC intron-variant

Variation tolerance for MUC19 Gene

Gene Damage Index Score: 39.90; 99.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC19 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC19 Gene

Disorders for MUC19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MUC19 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • xerodermosteosis
- elite association
Search MUC19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC19

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MUC19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC19 Gene

Publications for MUC19 Gene

  1. Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. (PMID: 12882755) Chen Y. … Wu R. (Am. J. Respir. Cell Mol. Biol. 2004) 2 67
  2. Salivary mucin 19 glycoproteins: innate immune functions in Streptococcus mutans-induced caries in mice and evidence for expression in human saliva. (PMID: 25512380) Culp D.J. … Cuadra-Saenz G. (J. Biol. Chem. 2015) 67
  3. Genome-wide association study signal at the 12q12 locus for Crohn's disease may represent associations with the MUC19 gene. (PMID: 23619718) Kumar V. … Levy E. (Inflamm. Bowel Dis. 2013) 67
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 67

Products for MUC19 Gene

Sources for MUC19 Gene

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