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MUC16 Gene

protein-coding GIFtS: 51

GC19M008904

mucin 16, cell surface associated
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CA-125 ^³
CA125 ^¹, ², ³
FLJ14303 ^¹, ²
MUC-16 ^³

Descriptions
CA125 ovarian cancer antigen ^²
Ovarian cancer-related tumor marker CA125 ^³
Ovarian carcinoma antigen CA125 ^³
mucin 16 ^²
mucin 16, cell surface associated ^²

External Ids
HGNC: 15582¹
Entrez Gene: 94025²
UniProtKB: Q8WXI7³
Ensembl: ENSG00000181143⁷

Search outside databases for aliases for MUC16 gene

Previous GC identifers: GC19M009087 GC19M009182 GC19M008805 GC19M008820 GC19U900441

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Function: Thought to provide a protective, lubricating barrier against particles and infectious

agents at mucosal surfaces (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

MUC16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M008904: (about GC identifiers)

Start:	8,820,520 bp from pter
End:	8,953,018 bp from pter
Size:	132,499 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7 (See protein sequence)

Recommended Name: Mucin-16

Size: 22152 amino acids; 2353428 Da

Subunit: Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to

the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the

mesothelial epithelium via binding to MSLN

Subcellular location: Cell membrane; Single-pass type I membrane protein. Secreted, extracellular

space. Note=May be liberated into the extracellular space following the phosphorylation of the

intracellular C-terminus which induces the proteolytic cleavage and liberation of the

extracellular domain

Miscellaneous: Antigen that is the basis for a widely used serum assay for the monitoring of

patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack

of specificity, it is of little value in the detection of early ovarian cancer. Due to its

similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used

for population screening

Secondary accessions: Q6ZQW5 Q96RK2

Post-translational modifications:

Heavily O-glycosylated; expresses both type 1 and type 2 core glycans¹

Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked

glycans¹

May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce

proteolytic cleavage and the liberation of the extracellular domain into the extracellular space¹

May contain numerous disulfide bridges. Association of several molecules of the secreted form may

occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in

the extracellular space or in the lumen of secretory ducts¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_078966.2

ENSEMBL proteins:

ENSP00000370342 ENSP00000381008 ENSP00000333016 ENSP00000370328

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MUC16)
	Human Recombinant Proteins from Abnova (MUC16)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0019898	extrinsic to membrane	IDA	12766047

About this table

Antibodies for MUC16:

	Invitrogen Antibodies for MUC16
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MUC16), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MUC16)
	Novus Biologicals Antibodies for MUC16

Assays for MUC16:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WXI7

ProtoNet protein and cluster: Q8WXI7

1 Blocks protein family: IPB000082 SEA domain

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Domain: Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing

more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a

C-terminal transmembrane contain domain with a short cytoplasmic tail

Similarity: Contains 2 ANK repeats

Similarity: Contains 14 LRR (leucine-rich) repeats

Similarity: Contains 56 SEA domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024690

Applied Biosystems Silencer® siRNAs for MUC16

Sigma-Aldrich siRNA for MUC16

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024690Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024690

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Function: Thought to provide a protective, lubricating barrier against particles and infectious

agents at mucosal surfaces (By similarity)

Induction: Up-regulated in ovarian cancer cells

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Muc16):

reproductive system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14676194

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MUC16

4 Interacting proteins for MUC16 (ENSP00000333016³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MSLN	ENSP00000372313³	STRING (score=.878)
MUC13	ENSP00000312235³	STRING (score=.73)
MUC15	ENSP00000303713³	STRING (score=.722)
LGALS1	ENSP00000215909³	STRING (score=.707)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	NAS	14676194

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MUC16
10/16 Novoseek chemical compound relationships for MUC16 gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
b 723	50.66	3	1376598 (1), 8980361 (1), 10506443 (1)
progesterone	35.17	22	8018399 (3), 1580164 (2), 9160304 (2), 15086841 (1) (see all 16)
gdp	15.39	8	18332454 (3), 15012688 (2)
sialic acid	8.39	6	8246875 (3), 10609502 (1), 11045795 (1)
p-007	8.12	1	16828852 (1)
tyrosine	4.48	4	9276028 (4)
17-hydroxyprogesterone	4.03	7	8018399 (3), 1580164 (2)
hematoxylin	1.72	1	18317224 (1)
fibrinogen	0.00	2	2080860 (1), 16686279 (1)
estradiol	0.00	7	1580164 (3), 9228498 (1), 18843968 (1), 11917376 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024690

Sigma-Aldrich siRNA for MUC16

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024690

REFSEQ mRNAs for MUC16 gene:

NM_024690.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024690

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024690

Additional cDNA sequence:

AF361486.3 AF414442.2 AK024365.1 AK056791.1 AK128856.1 AK128857.1

6 DOTS entries:

DT.101979541 DT.301887 DT.91683855 DT.101979543 DT.101979542 DT.121611200

highest scoring ESTs for MUC16:

AW992209 BE001831 BF868626 BG949756 AA076250 AA076251 AA425887 AA433988 AA661815 AI276341

Unigene Cluster for MUC16:

Mucin 16, cell surface associated

Hs.432676 [show with all ESTs]

Unigene Representative Sequence: AF414442

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000380955 ENST00000397910 ENST00000331986 ENST00000380941

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MUC16 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MUC16

¹ / ² / ³

3 probe-sets matching MUC16 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49094_at²^{, 3}	U95-B	2	1.00	0.50	1.00	1.00	AI923224	0.60	0.83	0.73	1
220196_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_024690	0.40	1.00	0.76	1
220196_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks MUC16 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGATCTGC

SOURCE GeneReport for Unigene cluster: Hs.432676
UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7
Tissue specificity: Expressed in corneal and conjunctival epithelia (at protein level).
Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared
to the expression in normal ovarian tissue and ovarian adenomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MUC16 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MUC16¹	--	mucin 16, cell surface associated	77.57(n) 70.04(a)	476718 XM_533922.2 XP_533922.2
chimpanzee (Pan troglodytes)	MUC16¹	--	mucin 16, cell surface associated	88.94(n) 86.32(a)	744458 XM_001149202.1 XP_001149202.1
mouse (Mus musculus)	Muc16⁵	9	mucin 16	--	AK003577
chicken (Gallus gallus)	MUC16¹	--	mucin 16, cell surface associated	56.25(n) 41.58(a)	769718 XM_001233005.1 XP_001233006.1

About this table Species with no ortholog for MUC16

ENSEMBL Gene Tree for MUC16

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MUC16 gene

ENSG00000214639² MUC4² RBMXL3² MUC17² TPRXL² MUC12²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Polymorphism: The number of repeats is highly polymorphic

10/970 NCBI SNPs in MUC16 are shown (see all 970 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 294)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1867691^1,2	A,C,F,H,O	8926632(-)	`TGTCCA/GTTGGT`	1	I/V	mis¹ ese³		7	NA EU EA WA	562
	rs2591593^1,2	A,C,F,H,O	8936969(+)	`CCTGCC/TCTGGA`	1	G/E	mis¹ ese³		7	EU EA WA NA	558
	rs953551^1,2	A,C,F,H,O	8937278(-)	`AAATAC/TGCCCC`	1	T/M	mis¹ ese³		13	EA NA EU WA	1162
	rs1596797^1,2	A,C,F,H,O	8949017(-)	`ATCAAA/CCTTAC`	1	K/N	mis¹		12	EA NA EU WA	1056
	rs2547072^1,2	A,C,F,H,O	8937083(+)	`CTGGTG/ATGACT`	1	I/T	mis¹ ese³		7	EU EA WA NA	562
	rs1862462^1,2	A,C,F,H,O	8938436(+)	`TCTTTG/AAAACC`	1	L/S	mis¹ ese³		11	NA EU EA WA	980
	rs1609458^1,2	A,C,F,H,O	8945299(-)	`CATGGA/GCCAGT`	1	T/A	mis¹ ese³		12	EU EA WA NA	1042
	rs2547065^1,2	A,C,F,H,O	8941462(-)	`GGGGAC/GCAGTC`	1	S/T	mis¹		12	EU EA WA NA	1054
	rs2591592^1,2	A,C,F,H,O	8936346(+)	`GATAAT/AACTTG`	1	F/I	mis¹		11	EU EA WA NA	982
	rs2547074^1,2	C,F,H,O	8937858(+)	`GGTTAC/TGTCCA`	1	V/I	mis¹ ese³		15	EU EA WA NA	1400

About this table

HapMap Linkage Disequilibrium images for MUC16 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606154

10/97 Novoseek disease relationships for MUC16 gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	88.38	310	17643440 (6), 16061277 (6), 10475127 (6), 17565840 (5) (see all 99)
ovarian carcinoma	84.42	84	12404282 (6), 1965803 (4), 12366659 (4), 12821338 (3) (see all 54)
ovarian tumor benign	83.87	11	1972127 (3), 10985621 (1), 16764622 (1), 12816688 (1) (see all 9)
recurrent ovarian cancer	79.97	15	15161704 (4), 12795808 (3), 17227902 (2), 1320853 (1) (see all 8)
ascites	72.66	73	12366659 (6), 17641444 (4), 16515612 (3), 10985621 (2) (see all 45)
cystadenocarcinoma serous	72.56	12	1506732 (2), 9852392 (2), 8494699 (1), 9329572 (1) (see all 6)
stage ovarian cancer	69.42	4	10402722 (1), 18414853 (1), 17498784 (1), 19060592 (1)
meigs syndrome	67.92	6	16515612 (3), 15906965 (2), 10192495 (1)
tumors	67.35	373	9234924 (6), 16880776 (6), 17113137 (5), 16942793 (5) (see all 99)
adnexal mass	66.83	4	17335881 (1), 18061248 (1), 17290603 (1), 18177570 (1)

About this table

Human Genome Epidemiology Navigator: MUC16 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/614 PubMed articles for MUC16 gene (see all 614 ):

Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. (PubMed id 11369781)^{1, 2, 3, 4} Yin B.W.T. and Lloyd K.O. (2001)
Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. (PubMed id 12734200)^{1, 3, 4} Kui Wong N.... Patankar M.S. (2003)
Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. (PubMed id 15788735)^{1, 3, 4} McLemore M.R. and Aouizerat B. (2005)
Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. (PubMed id 14676194)^{1, 3, 4} Rump A....Miyajima A. (2004)
Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye. (PubMed id 16384952)^{3, 4} Argueso P.... Gipson I.K. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The CA 125 gene: a newly discovered extension of the glycosylated N- terminal domain doubles the size of this extracellular superstructure. (PubMed id 12218296)^{3, 4} O'Brien T.J.... Shigemasa K. (2002)
The CA 125 gene: an extracellular superstructure dominated by repeat sequences. (PubMed id 11786729)^{3, 4} O'Brien T.J....York L. (2001)
CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line. (PubMed id 9276028)^{1, 4} Fendrick J.L....O'Brien T.J. (1997)
CA125 expression in patients with non-Hodgkin's lymphoma. (PubMed id 16923563)^{1, 3} Wei G....Qiaohua Z. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 94025	HGNC: 15582	Ensembl:ENSG00000181143	euGenes: HUgn94025	ECgene: MUC16
H-InvDB: MUC16

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MUC16	Genetics and Cytogenetics in Oncology and Haematology
Mucin database	http://www.medkem.gu.se/mucinbiology/databases/

Licensable Technologies for MUC16
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MUC16:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MUC16-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MUC16		Browse antibodies at Sigma-Aldrich
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Antibodies for MUC16

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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MUC16 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for MUC16

Summaries
for MUC16

Genomic Location
for MUC16

Proteins
for MUC16

Protein Domains/
Families
for MUC16

Gene Function
for MUC16

Pathways & Interactions
for MUC16

Drugs & Compounds
for MUC16

Transcripts
for MUC16

Expression
for MUC16

Orthologs
for MUC16

Paralogs
for MUC16

SNPs/Variants
for MUC16

Disorders & Mutations
for MUC16

Medical News
for MUC16

Publications
for MUC16

Search for MUC16

Genome Databases showing MUC16

Other Databases showing MUC16

Specialized Databases showing MUC16

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MUC16 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor MUC16

Summariesfor MUC16

Genomic Locationfor MUC16

Proteinsfor MUC16

Protein Domains/Familiesfor MUC16

Gene Functionfor MUC16

Pathways & Interactionsfor MUC16

Drugs & Compoundsfor MUC16

Transcriptsfor MUC16

Expression for MUC16

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Disorders & Mutationsfor MUC16

Medical Newsfor MUC16

Publicationsfor MUC16

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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