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Aliases for MUC16 Gene

Aliases for MUC16 Gene

  • Mucin 16, Cell Surface Associated 2 3 5
  • Ovarian Cancer-Related Tumor Marker CA125 3 4
  • Ovarian Carcinoma Antigen CA125 3 4
  • CA125 3 4
  • CA125 Ovarian Cancer Antigen 3
  • CA-125 4
  • MUC-16 4

External Ids for MUC16 Gene

Previous GeneCards Identifiers for MUC16 Gene

  • GC19M009087
  • GC19M009182
  • GC19M008805
  • GC19M008820
  • GC19U900441
  • GC19M008960
  • GC19M008584

Summaries for MUC16 Gene

GeneCards Summary for MUC16 Gene

MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include Ovarian Cancer and Pseudo-Meigs Syndrome. Among its related pathways are Diseases associated with O-glycosylation of proteins and Defective GALNT12 causes colorectal cancer 1 (CRCS1).

UniProtKB/Swiss-Prot for MUC16 Gene

  • Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Gene Wiki entry for MUC16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC16 Gene

Genomics for MUC16 Gene

Regulatory Elements for MUC16 Gene

Enhancers for MUC16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MUC16 on UCSC Golden Path with GeneCards custom track

Genomic Location for MUC16 Gene

Chromosome:
19
Start:
8,848,844 bp from pter
End:
8,981,342 bp from pter
Size:
132,499 bases
Orientation:
Minus strand

Genomic View for MUC16 Gene

Genes around MUC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC16 Gene

Proteins for MUC16 Gene

  • Protein details for MUC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXI7-MUC16_HUMAN
    Recommended name:
    Mucin-16
    Protein Accession:
    Q8WXI7
    Secondary Accessions:
    • Q6ZQW5
    • Q96RK2

    Protein attributes for MUC16 Gene

    Size:
    22152 amino acids
    Molecular mass:
    2353428 Da
    Quaternary structure:
    • Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
    Miscellaneous:
    • Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.

neXtProt entry for MUC16 Gene

Proteomics data for MUC16 Gene at MOPED

Post-translational modifications for MUC16 Gene

  • Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
  • Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
  • May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
  • May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
  • Glycosylation at Asn 139, Asn 434, Ser 472, Ser 475, Ser 477, Thr 480, Thr 628, Ser 708, Ser 709, Thr 718, Asn 787, Ser 918, Asn 930, Asn 957, Asn 1375, Thr 1512, Asn 1633, Asn 1840, Thr 1870, Asn 1877, Asn 1890, Asn 2345, Asn 2375, Asn 2737, Thr 2983, Asn 3086, Ser 3147, Ser 3150, Asn 3179, Ser 3211, Ser 3402, Ser 3417, Asn 3502, Ser 3796, Thr 3800, Ser 3802, Thr 3807, Ser 3808, Thr 3821, Ser 3832, Thr 4009, Thr 4016, Ser 4060, Thr 4137, Asn 4222, Thr 4257, Asn 4500, Asn 4608, Asn 4615, Asn 4626, Ser 4662, Asn 4863, Thr 5093, Asn 5098, Asn 5133, Thr 5191, Asn 5230, Thr 5244, Thr 5264, Asn 5322, Asn 5396, Asn 5472, Ser 5556, Asn 5691, Ser 5778, Asn 5865, Ser 5902, Thr 5905, Thr 5906, Thr 5907, Thr 6073, Ser 6074, Asn 6090, Thr 6265, Ser 6360, Thr 6363, Ser 6386, Thr 6394, Thr 6397, Thr 6398, Thr 6431, Thr 6451, Thr 6577, Thr 6684, Thr 6685, Asn 6734, Asn 6861, Ser 6950, Thr 6952, Asn 6963, Ser 7071, Ser 7245, Thr 7371, Ser 7541, Thr 7616, Ser 7676, Ser 7679, Ser 7829, Thr 7832, Ser 7960, Ser 7963, Asn 8031, Asn 8057, Thr 8118, Ser 8241, Asn 8326, Thr 8413, Ser 8543, Asn 8620, Thr 8647, Asn 8686, Thr 8717, Thr 8793, Ser 8813, Thr 8817, Ser 8819, Thr 8822, Ser 8842, Ser 8845, Thr 8886, Asn 8915, Ser 9012, Asn 9204, Thr 9365, Thr 9370, Asn 9495, Ser 9554, Ser 9719, Asn 9787, Thr 9814, Thr 9874, Asn 9920, Ser 9996, Thr 10000, Asn 10077, Asn 10175, Ser 10303, Thr 10428, Thr 10436, Thr 10456, Ser 10457, Thr 10458, Ser 10459, Ser 10462, Asn 10512, Ser 10694, Asn 10702, Asn 10751, Thr 10800, Asn 11055, Asn 11226, Asn 11265, Asn 11369, Asn 11596, Thr 11610, Ser 11611, Ser 11838, Ser 11965, Asn 12081, Asn 12102, Asn 12118, Asn 12170, Asn 12237, Asn 12274, Asn 12395, Asn 12416, Asn 12432, Asn 12551, Asn 12572, Asn 12588, Asn 12706, Asn 12727, Asn 12743, Asn 12826, Asn 12862, Asn 12883, Asn 12982, Asn 13018, Asn 13039, Asn 13055, Asn 13174, Asn 13195, Asn 13211, Asn 13330, Asn 13351, Asn 13367, Asn 13423, Asn 13486, Asn 13507, Asn 13523, Asn 13579, Asn 13642, Asn 13663, Asn 13679, Asn 13798, Asn 13819, Asn 13835, Asn 13954, Asn 13975, Asn 13991, Asn 14110, Asn 14131, Asn 14147, Asn 14266, Asn 14287, Asn 14303, Asn 14359, Asn 14422, Asn 14459, Asn 14580, Asn 14601, Asn 14617, Asn 14736, Asn 14757, Asn 14773, Asn 14825, Asn 14892, Asn 14913, Asn 14929, Asn 15048, Asn 15069, Asn 15204, Asn 15241, Asn 15360, Asn 15381, Asn 15397, Asn 15516, Asn 15537, Asn 15672, Asn 15693, Asn 15709, Asn 15827, Asn 15848, Asn 15864, Asn 15947, Asn 15983, Asn 16004, Asn 16020, Asn 16138, Asn 16159, Asn 16175, Asn 16258, Asn 16294, Asn 16315, Asn 16331, Asn 16450, Asn 16471, Asn 16487, Asn 16539, Asn 16606, Asn 16627, Asn 16643, Asn 16762, Asn 16783, Asn 16799, Asn 16918, Asn 16939, Asn 16955, Asn 17074, Asn 17095, Asn 17111, Asn 17230, Asn 17251, Asn 17386, Asn 17407, Asn 17423, Asn 17542, Asn 17563, Asn 17579, Asn 17698, Asn 17719, Asn 17854, Asn 17875, Asn 17891, Asn 18010, Asn 18031, Asn 18047, Asn 18166, Asn 18187, Asn 18203, Asn 18322, Asn 18343, Asn 18359, Asn 18478, Asn 18499, Asn 18515, Asn 18634, Asn 18655, Asn 18790, Asn 18811, Asn 18827, Asn 18946, Asn 18967, Asn 18983, Asn 19039, Asn 19102, Asn 19123, Asn 19139, Asn 19258, Asn 19279, Asn 19295, Asn 19414, Asn 19435, Asn 19451, Asn 19570, Asn 19591, Asn 19607, Asn 19726, Asn 19747, Asn 19763, Asn 19881, Asn 19902, Asn 19918, Asn 20037, Asn 20058, Asn 20074, Asn 20157, Asn 20193, Asn 20214, Asn 20230, Asn 20349, Asn 20370, Asn 20505, Asn 20526, Asn 20661, Asn 20682, Asn 20698, Asn 20817, Asn 20838, Asn 20973, Asn 20994, Asn 21010, Asn 21129, Asn 21150, Asn 21166, Asn 21285, Asn 21306, Asn 21378, Asn 21389, Ser 21419, Asn 21441, Asn 21461, Asn 21477, Asn 21574, Asn 21595, Asn 21725, Asn 21745, Asn 21840, Asn 21857, Asn 21899, Asn 21932, Asn 21971, Asn 22008, Asn 22062, and Asn 22068
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC16 Gene

No data available for DME Specific Peptides for MUC16 Gene

Domains & Families for MUC16 Gene

Gene Families for MUC16 Gene

HGNC:

Protein Domains for MUC16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXI7

UniProtKB/Swiss-Prot:

MUC16_HUMAN :
  • Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
  • Contains 2 ANK repeats.
Domain:
  • Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
  • Contains 56 SEA domains.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with MUC16: view

Function for MUC16 Gene

Molecular function for MUC16 Gene

UniProtKB/Swiss-Prot Function:
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
UniProtKB/Swiss-Prot Induction:
Up-regulated in ovarian cancer cells.

Phenotypes for MUC16 Gene

genes like me logo Genes that share phenotypes with MUC16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MUC16

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUC16 Gene

Localization for MUC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC16 Gene

Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC16 Gene COMPARTMENTS Subcellular localization image for MUC16 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4
cytoskeleton 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MUC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MUC16: view

Pathways & Interactions for MUC16 Gene

genes like me logo Genes that share pathways with MUC16: view

Gene Ontology (GO) - Biological Process for MUC16 Gene

None

No data available for SIGNOR curated interactions for MUC16 Gene

Drugs & Compounds for MUC16 Gene

(23) Drugs for MUC16 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oregovomab Investigational Pharma antigen, Target immunological response against cancer antigen 0
ABAGOVOMAB Pharma 0
DMUC5754A Pharma unknown, inhibitor 0
OREGOVAMAB Pharma 0

(17) Additional Compounds for MUC16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MUC16: view

Transcripts for MUC16 Gene

mRNA/cDNA for MUC16 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC16 Gene

Mucin 16, cell surface associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC16 Gene

No ASD Table

Relevant External Links for MUC16 Gene

GeneLoc Exon Structure for
MUC16
ECgene alternative splicing isoforms for
MUC16

Expression for MUC16 Gene

mRNA expression in normal human tissues for MUC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC16 Gene

This gene is overexpressed in Cervix - Endocervix (x24.2), Minor Salivary Gland (x8.7), and Adipose - Visceral (Omentum) (x8.3).

Protein differential expression in normal tissues from HIPED for MUC16 Gene

This gene is overexpressed in Cervix (19.9), Breast (18.8), Liver (11.8), and Platelet (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC16 Gene



SOURCE GeneReport for Unigene cluster for MUC16 Gene Hs.432676

mRNA Expression by UniProt/SwissProt for MUC16 Gene

Q8WXI7-MUC16_HUMAN
Tissue specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
genes like me logo Genes that share expression patterns with MUC16: view

Primer Products

No data available for Protein tissue co-expression partners for MUC16 Gene

Orthologs for MUC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC16 35
  • 94.14 (n)
  • 90.21 (a)
cow
(Bos Taurus)
Mammalia MUC16 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MUC16 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MUC16 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Muc16 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUC16 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MUC16 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MUC16 36
  • 40 (a)
OneToOne
Species with no ortholog for MUC16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC16 Gene

ENSEMBL:
Gene Tree for MUC16 (if available)
TreeFam:
Gene Tree for MUC16 (if available)

Paralogs for MUC16 Gene

No data available for Paralogs for MUC16 Gene

Variants for MUC16 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC16 Gene

MUC16_HUMAN-Q8WXI7
The number of repeats is highly polymorphic.

Sequence variations from dbSNP and Humsavar for MUC16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17000957 - 8,979,506(+) CTCTG(C/T)TTTCA reference, missense
rs17000950 - 8,978,096(+) TTCCC(C/T)GATAG reference, missense
rs10411228 - 8,978,045(+) CATAG(A/T)GCCTG reference, missense
rs10406202 - 8,978,018(+) AATTG(A/G)GATGT reference, missense
rs17000947 - 8,977,654(+) TGGGA(A/G)TAGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MUC16 Gene

Variant ID Type Subtype PubMed ID
nsv469648 CNV Complex 16826518
nsv428362 CNV Gain+Loss 18775914
nsv483078 CNV Complex 15286789
nsv911019 CNV Gain 21882294
dgv48n68 CNV Gain 17160897
dgv1056e1 CNV Complex 17122850
nsv2406 CNV Insertion 18451855
esv2718141 CNV Deletion 23290073
esv2221846 CNV Deletion 18987734
esv2664410 CNV Deletion 23128226
esv2718142 CNV Deletion 23290073
esv2718143 CNV Deletion 23290073
esv2718144 CNV Deletion 23290073
esv2117991 CNV Deletion 18987734
esv2718145 CNV Deletion 23290073
esv2718146 CNV Deletion 23290073
nsv2407 CNV Insertion 18451855
dgv621e199 CNV Deletion 23128226
esv2718147 CNV Deletion 23290073
nsv523652 CNV Loss 19592680
nsv470123 CNV Loss 18288195

Variation tolerance for MUC16 Gene

Residual Variation Intolerance Score: 100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 31.77; 99.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for MUC16 Gene

Disorders for MUC16 Gene

MalaCards: The human disease database

(17) MalaCards diseases for MUC16 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
pseudo-meigs syndrome
  • pseudo-demons-meigs syndrome
serous cystadenocarcinoma
  • serous adenocarcinoma
endometriosis
bronchogenic cyst
- elite association - COSMIC cancer census association via MalaCards
Search MUC16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC16

Genetic Association Database (GAD)
MUC16
Human Genome Epidemiology (HuGE) Navigator
MUC16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC16
genes like me logo Genes that share disorders with MUC16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC16 Gene

Publications for MUC16 Gene

  1. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. (PMID: 11369781) Yin B.W.T. … Lloyd K.O. (J. Biol. Chem. 2001) 2 3 4 67
  2. MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brain. (PMID: 20090516) Johnson M.D. … Xu H. (Appl. Immunohistochem. Mol. Morphol. 2010) 3 23
  3. Heart failure in patients with aortic stenosis: clinical and prognostic significance of carbohydrate antigen 125 and brain natriuretic peptide measurement. (PMID: 17662495) Antonini-Canterin F. … Nicolosi G.L. (Int. J. Cardiol. 2008) 3 23
  4. Increased serum tumor markers (CA125 and CA15.3) in primary plasma cell leukemia: a case report and review of the literature. (PMID: 18854288) de Larrea C.F. … BladAc J. (Clin Lymphoma Myeloma 2008) 3 23
  5. CA125 expression in patients with non-Hodgkin's lymphoma. (PMID: 16923563) Wei G. … Qiaohua Z. (Leuk. Lymphoma 2006) 3 23

Products for MUC16 Gene

Sources for MUC16 Gene

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