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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MUC16 Gene

protein-coding GIFtS: 54
GCID: GC19M008960

mucin 16, cell surface associated

Explore 136 diseases affiliated with
MUC16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mucin 16, Cell Surface Associated¹ ²		MUC-16² ³
CA125¹ ² ³		FLJ14303¹
Ovarian Cancer-Related Tumor Marker CA125² ³		CA125 Ovarian Cancer Antigen²
Ovarian Carcinoma Antigen CA125² ³		Mucin-16¹
CA-125² ³

External Ids:	HGNC: 15582¹	Entrez Gene: 94025²	Ensembl: ENSG00000181143⁷	OMIM: 606154⁵	UniProtKB: Q8WXI7³

Export aliases for MUC16 gene to outside databases

Previous GC identifers: GC19M009087 GC19M009182 GC19M008805 GC19M008820 GC19U900441 GC19M008904 GC19M008584

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Function: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal

surfaces (By similarity)

Gene Wiki entry for MUC16 (CA-125)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MUC16
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MUC16 promoter sequence

Search SABiosciences Chromatin IP Primers for MUC16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

MUC16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC16 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M008960: view genomic region (about GC identifiers)

Start:	8,959,520 bp from pter	End:	9,092,018 bp from pter
Size:	132,499 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7 (See protein sequence)

Recommended Name: Mucin-16

Size: 22152 amino acids; 2353428 Da

Subunit: Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of

ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN

Subcellular location: Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be

liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the

proteolytic cleavage and liberation of the extracellular domain

Miscellaneous: Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian

epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in

the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not

specific enough to be used for population screening

Secondary accessions: Q6ZQW5 Q96RK2

Explore the universe of human proteins at neXtProt for MUC16: NX_Q8WXI7

Post-translational modifications:

Heavily O-glycosylated; expresses both type 1 and type 2 core glycans¹

Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans¹

May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the

liberation of the extracellular domain into the extracellular space¹

May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through

interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the

lumen of secretory ducts¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WXI7

MUC16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_078966.2

ENSEMBL proteins:

ENSP00000381008

Reactome Protein details: Q8WXI7
Human Recombinant Protein Products:

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	Uscn Proteins for MUC16

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005796	Golgi lumen	TAS	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0019898	extrinsic to membrane	IDA	12766047

MUC16 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MUC16

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MUC16 for domains About GeneDecksing

1 InterPro domain/family:

IPR000082 SEA

Graphical View of Domain Structure for InterPro Entry Q8WXI7

ProtoNet protein and cluster: Q8WXI7

1 Blocks protein family: IPB000082 SEA domain

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Domain: Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60

partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain

domain with a short cytoplasmic tail

Similarity: Contains 2 ANK repeats

Similarity: Contains 56 SEA domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Function: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal

surfaces (By similarity)

Induction: Up-regulated in ovarian cancer cells

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC16

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14676194

MUC16 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein

Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein	1.00	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein	1.00
Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein	1.00	Termination of O-glycan biosynthesis	0.69
Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein	1.00	O-linked glycosylation of mucins	0.28

Asparagine N-linked glycosylation

Post-translational protein modification

0.44

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for MUC16 (see all 8)

	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
	O-linked glycosylation of mucins
	Metabolism of proteins
	Post-translational protein modification
	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein

MUC16 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MUC16

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for MUC16 (Q8WXI7³ ENSP00000381008⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LGALS1	P09382³, ENSP00000215909⁴	I2D: score=3 STRING: ENSP00000215909
MSLN	Q13421³, ENSP00000372313⁴	I2D: score=1 STRING: ENSP00000372313
LGALS3	P17931³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	NAS	14676194
GO:0016266	O-glycan processing	TAS	--
GO:0043687	post-translational protein modification	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

MUC16 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MUC16 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MUC16
10/36 Novoseek chemical compound relationships for MUC16 gene (see all 36) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
b 723	49.2	3	1376598 (1), 8980361 (1), 10506443 (1)
paclitaxel	45.3	2	20173382 (1), 19818996 (1)
icodextrin	45.1	16	16686279 (4), 16178478 (2), 10911654 (1), 16257844 (1) (see all 5)
progesterone	37.8	28	8018399 (3), 1580164 (2), 20373934 (2), 20356397 (2) (see all 20)
carboplatin	37.1	2	20173382 (1), 19818996 (1)
estrogen	34	22	9160304 (3), 20356397 (2), 8980361 (1), 15086841 (1) (see all 19)
cisplatin	28.1	5	8377503 (3), 10883888 (1)
vegf	26.9	35	18366924 (5), 15559485 (4), 15384786 (3), 18552237 (3) (see all 15)
gdp	18.6	8	18332454 (3), 15012688 (2)
paraffin	15.5	3	12821338 (2), 16923563 (1)

Search CenterWatch for drugs/clinical trials and news about MUC16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MUC16 gene:

NM_024690.2

Unigene Cluster for MUC16:

Mucin 16, cell surface associated

Hs.432676 [show with all ESTs]

Unigene Representative Sequence: AF414442

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000397910(uc010dwj.3 uc021uog.1 uc002mkp.3)

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Additional cDNA sequence:

AF361486.3 AF414442.2 AK024365.1 AK056791.1 AK128856.1 AK128857.1 AM903345.1

6 DOTS entries:

DT.101979541 DT.301887 DT.91683855 DT.101979543 DT.101979542 DT.121611200

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MUC16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGATCTGC

About this image

MUC16 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature airway epithelial cells (Directed differentia...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MUC16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MUC16

SOURCE GeneReport for Unigene cluster: Hs.432676

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Tissue specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian

carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and

ovarian adenomas

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MUC16 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	CABZ01072534.1⁶	--	8(a)	1 ↔ 1	1(41080395-41120369)
fruit fly (Drosophila melanogaster)	Insecta	Muc14A¹	Mucin 14A	36.44(n) 24.83(a)		318097 NM_167482.3 NP_727928.3
worm (Caenorhabditis elegans)	Secernentea	F26C11.3⁶	Uncharacterized protein F26C11.3	8(a)	possible ortholog	II(9903000-9915040)

Species with no ortholog for MUC16

ENSEMBL Gene Tree for MUC16 (if available)
TreeFam Gene Tree for MUC16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MUC16 gene

LOC100131514² MUC3A² MUC12² MUC17² MUC22²

MUC16 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7

Polymorphism: The number of repeats is highly polymorphic

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147760980^1,2	C,	other	9075492(+)	`TGGTGA/GAGGTT`	2	S F	mis¹		0	--	--	--	--
rs2969291^1,2	C,F,H,	--	8959049(-)	`AGAGCA/GAGACT`	1	--	ds500¹		8		NA WA CSA	15
rs2972590^1,2	C,F,H,	--	8959080(+)	`GTGGCA/GTGATC`	1	--	ds500¹		8		NA WA CSA	15
rs190935975^1,2		--	8959104(+)	`ACCTCC/TGCTTC`	1	--	ds500¹		0	--	--	--	--
rs2969290^1,2	C,F,H,	--	8959163(-)	`TCCACG/ACCTGT`	1	--	ds500¹		3		NA	6
rs142659622^1,2		--	8959208(+)	`GAGACA/TGGGTT`	1	--	ds500¹		0	--	--	--	--
rs146074370^1,2		--	8959223(+)	`CAAGTC/TGGCCA`	1	--	ds500¹		0	--	--	--	--
rs140003922^1,2		--	8959268(+)	`CACCCA/GCCTGG`	1	--	ds500¹		0	--	--	--	--
rs181937968^1,2		--	8959403(+)	`TGGTGC/TGAAAC`	1	--	ds500¹		0	--	--	--	--
rs141470765^1,2		--	8959446(+)	`TTCACA/GAAGGT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MUC16 (8959520 - 9092018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for MUC16
11 CNVs: 89074 78073 78074 78071 0220 5083 89075 35699 4067 78072 35698
2 Indels: 45817 45818

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC16

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MUC16 for disorders           About GeneDecksing

OMIM gene information: 606154    OMIM disorders: --

20/136 diseases for MUC16 (see all 136):    About MalaCards

ovarian cancer corpus luteum cyst protein-losing enteropathy struma ovarii

ovarian carcinoma serous cystadenocarcinoma ovarian serous cystadenocarcinoma cystadenocarcinoma

sertoli-leydig cell tumor carcinoma pericardial effusion catamenial pneumothorax

mucinous cystadenocarcinoma bronchogenic cyst mixed connective tissue disease connective tissue disease

fallopian tube carcinoma paraneoplastic cerebellar degeneration non-small cell lung carcinoma papillary serous carcinoma of the peritoneum

1 disease from the University of Copenhagen DISEASES database for MUC16:

Ovarian cancer

10/97 Novoseek disease relationships for MUC16 gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	88.9	345	17643440 (6), 16061277 (6), 19818123 (6), 10475127 (6) (see all 99)
ovarian carcinoma	85.3	87	12404282 (6), 1965803 (4), 12366659 (4), 12821338 (3) (see all 57)
ovarian tumor benign	84.1	12	1972127 (3), 10985621 (1), 19662218 (1), 17498784 (1) (see all 10)
recurrent ovarian cancer	79.7	17	15161704 (4), 12795808 (3), 17227902 (2), 20368726 (2) (see all 9)
stage ovarian cancer	75.1	15	19818996 (3), 20037204 (3), 19662218 (2), 10402722 (1) (see all 8)
ascites	72.7	79	12366659 (6), 17641444 (4), 16515612 (3), 10985621 (2) (see all 49)
cystadenocarcinoma serous	71	12	1506732 (2), 9852392 (2), 8494699 (1), 9329572 (1) (see all 6)
tumors	68.5	415	9234924 (6), 16880776 (6), 17113137 (5), 16942793 (5) (see all 99)
adnexal mass	68	6	17335881 (1), 18061248 (1), 17290603 (1), 19899428 (1) (see all 6)
meigs syndrome	66.6	6	16515612 (3), 15906965 (2), 10192495 (1)

Human Genome Epidemiology (HuGE) Navigator: MUC16 (3 documents)

Export disorders for MUC16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MUC16 gene, integrated from 9 sources (see all 740):
(articles sorted by number of sources associating them with MUC16)

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Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. (PubMed id 11369781)^{1, 2, 3, 9} Yin B.W.T. and Lloyd K.O. (2001)
Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. (PubMed id 12734200)^{1, 2, 9} Kui Wong N.... Patankar M.S. (2003)
Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. (PubMed id 15788735)^{1, 2, 9} McLemore M.R. and Aouizerat B. (2005)
Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. (PubMed id 14676194)^{1, 2, 9} Rump A....Miyajima A. (2004)
Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye. (PubMed id 16384952)^{1, 2} Argueso P.... Gipson I.K. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The CA 125 gene: a newly discovered extension of the glycosylated N- terminal domain doubles the size of this extracellular superstructure. (PubMed id 12218296)^{1, 2} O'Brien T.J.... Shigemasa K. (2002)
The CA 125 gene: an extracellular superstructure dominated by repeat sequences. (PubMed id 11786729)^{1, 2} O'Brien T.J....York L. (2001)
CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line. (PubMed id 9276028)^{2, 9} Fendrick J.L....O'Brien T.J. (1997)
CA125 expression in patients with non-Hodgkin's lymphoma. (PubMed id 16923563)^{1, 9} Wei G....Qiaohua Z. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 94025	HGNC: 15582	Ensembl:ENSG00000181143	euGenes: HUgn94025	ECgene: MUC16
H-InvDB: MUC16

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MUC16	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MUC16	Genetics and Cytogenetics in Oncology and Haematology
Mucin database	http://www.medkem.gu.se/mucinbiology/databases/

Intellectual Property for MUC16 gene
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Patent Information for MUC16 gene:
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Corpus Luteum Cyst
stable disease
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ADENOCARCINOMA LUNG
stage ovarian cancer
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MUC16 Gene

mucin 16, cell surface associated

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