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MUC16 Gene

protein-coding   GIFtS: 54
GCID: GC19M008960

Mucin 16, Cell Surface Associated

  See MUC16-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mucin 16, Cell Surface Associated1 2     CA-1252 3
CA1252 3 5     MUC-162 3
Ovarian Cancer-Related Tumor Marker CA1252 3     CA125 Ovarian Cancer Antigen2
Ovarian Carcinoma Antigen CA1252 3     mucin-162

External Ids:    HGNC: 155821   Entrez Gene: 940252   Ensembl: ENSG000001811437   OMIM: 6061545   UniProtKB: Q8WXI73   

Export aliases for MUC16 gene to outside databases

Previous GC identifers: GC19M009087 GC19M009182 GC19M008805 GC19M008820 GC19U900441 GC19M008904 GC19M008584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MUC16 Gene:
MUC16 (mucin 16, cell surface associated) is a protein-coding gene. Diseases associated with MUC16 include pseudo-meigs syndrome, and meigs syndrome.

UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7
Function: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal
surfaces (By similarity)

Gene Wiki entry for MUC16 (CA-125) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MUC16
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMUC16 promoter sequence
   Search Chromatin IP Primers for MUC16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

MUC16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC16 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M008960:  view genomic region     (about GC identifiers)

Start:
8,959,520 bp from pter      End:
9,092,018 bp from pter
Size:
132,499 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7 (See protein sequence)
Recommended Name: Mucin-16  
Size: 22152 amino acids; 2353428 Da
Subunit: Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis
of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to
MSLN
Miscellaneous: Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian
epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value
in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions,
it is not specific enough to be used for population screening
Secondary accessions: Q6ZQW5 Q96RK2

Explore the universe of human proteins at neXtProt for MUC16: NX_Q8WXI7

Explore proteomics data for MUC16 at MOPED

Post-translational modifications: 

  • Heavily O-glycosylated; expresses both type 1 and type 2 core glycans1
  • Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans1
  • May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and
    the liberation of the extracellular domain into the extracellular space1
  • May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through
    interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in
    the lumen of secretory ducts1
  • Glycosylation2 at Asn139, Asn434, Ser472, Ser475, Ser477, Thr480, Ser620, Thr623, Thr624, Thr628,
                                 Ser708, Ser709, Thr718, Asn787, Ser908, Ser912, Ser913, Ser914, Ser918, Asn930 (see all 515)
  • Modification sites at PhosphoSitePlus

  • See MUC16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078966.2  
    ENSEMBL proteins: 
     ENSP00000381008   ENSP00000472883   ENSP00000470885   ENSP00000472781   ENSP00000370338  
    Reactome Protein details: Q8WXI7

    MUC16 Human Recombinant Protein Products:

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    Novus Biologicals MUC16 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MUC16 

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    MUC16 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for MUC16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MUC: Mucins

    2 InterPro protein domains:
     IPR028850 MUC16
     IPR000082 SEA_dom

    Graphical View of Domain Structure for InterPro Entry Q8WXI7

    ProtoNet protein and cluster: Q8WXI7

    1 Blocks protein domain: IPB000082 SEA domain

    UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7
    Domain: Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60
    partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane
    contain domain with a short cytoplasmic tail
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 56 SEA domains


    Find genes that share domains with MUC16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC16_HUMAN, Q8WXI7
    Function: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal
    surfaces (By similarity)
    Induction: Up-regulated in ovarian cancer cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14676194
         
    Find genes that share ontologies with MUC16           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MUC16
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MUC16
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    miRNA
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    Block miRNA regulation of human, mouse, rat MUC16 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MUC16:
    hsa-miR-299-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MUC16

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC16

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUC16_HUMAN, Q8WXI7: Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May
    be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which
    induces the proteolytic cleavage and liberation of the extracellular domain
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    golgi apparatus4
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane IEA--
    GO:0009897external side of plasma membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MUC16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MUC16 About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with MUC16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for MUC16
        O-linked glycosylation of mucins
    Termination of O-glycan biosynthesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MUC16
    Interactions:

        GeneGlobe Interaction Network for MUC16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MUC16 (Q8WXI73 ENSP000003810084) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS1P093823, ENSP000002159094I2D: score=3 STRING: ENSP00000215909
    MSLNQ134213, ENSP000003723134I2D: score=1 STRING: ENSP00000372313
    LGALS3P179313I2D: score=1 
    RPS15AENSP000003186464STRING: ENSP00000318646
    BSNENSP000002964524STRING: ENSP00000296452
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS14676194
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with MUC16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MUC16

    Selected Novoseek inferred chemical compound relationships for MUC16 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b 723 49.2 3 1376598 (1), 8980361 (1), 10506443 (1)
    paclitaxel 45.3 2 20173382 (1), 19818996 (1)
    icodextrin 45.1 16 16686279 (4), 16178478 (2), 10911654 (1), 16257844 (1) (see all 5)
    progesterone 37.8 28 8018399 (3), 1580164 (2), 20373934 (2), 20356397 (2) (see all 20)
    carboplatin 37.1 2 20173382 (1), 19818996 (1)
    estrogen 34 22 9160304 (3), 20356397 (2), 8980361 (1), 15086841 (1) (see all 19)
    cisplatin 28.1 5 8377503 (3), 10883888 (1)
    vegf 26.9 35 18366924 (5), 15559485 (4), 15384786 (3), 18552237 (3) (see all 15)
    gdp 18.6 8 18332454 (3), 15012688 (2)
    paraffin 15.5 3 12821338 (2), 16923563 (1)



    Find genes that share compounds with MUC16           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MUC16 gene: 
    NM_024690.2  

    Unigene Cluster for MUC16:

    Mucin 16, cell surface associated
    Hs.432676  [show with all ESTs]
    Unigene Representative Sequence: AF414442
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397910(uc010dwj.3 uc021uog.1 uc002mkp.3) ENST00000596768
    ENST00000601404 ENST00000599436 ENST00000596956 ENST00000380951
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MUC16 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MUC16:
    hsa-miR-299-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MUC16
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    GenScript: all cDNA clones in your preferred vector: MUC16 (NM_024690)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC16
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC16
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MUC16
      QuantiFast Probe-based Assays in human, mouse, rat MUC16

    Additional mRNA sequence: 

    AF361486.3 AF414442.2 AK024365.1 AK056791.1 AK128856.1 AK128857.1 AM903345.1 

    6 DOTS entries:

    DT.101979541  DT.301887  DT.91683855  DT.101979543  DT.101979542  DT.121611200 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MUC16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGATCTGC
    MUC16 Expression
    About this image


    MUC16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Lung (Respiratory System)
             Mature airway epithelial cells
     
     Ovary (Reproductive System)
             Oviduct
    MUC16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MUC16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432676

    UniProtKB/Swiss-Prot: MUC16_HUMAN, Q8WXI7
    Tissue specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian
    carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian
    tissue and ovarian adenomas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MUC16 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MUC166
    mucin 16, cell surface associated
    40(a)
    1 ↔ 1
    28(1851800-1862161)
    lizard
    (Anolis carolinensis)
    Reptilia MUC166
    mucin 16, cell surface associated
    40(a)
    1 ↔ 1
    AAWZ02040145(229-5876)
            Species with no ortholog for MUC16

    ENSEMBL Gene Tree for MUC16 (if available)
    TreeFam Gene Tree for MUC16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    MUC16_HUMAN, Q8WXI7: The number of repeats is highly polymorphic


    Selected SNPs for MUC16 (see all 5394)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477609801,2
    Cuntested19075492(+) TGGTGA/GAGGTT 2 S F mis10--------
    rs1137846481,2
    C,Funtested19086424(+) GCTGTG/AGACAT 2 /S syn11Minor allele frequency- A:0.50CSA 2
    rs29692911,2
    C,F,H--8959049(-) agagcA/Gagact 1 -- ds50018Minor allele frequency- G:0.13NA WA CSA 15
    rs29725901,2
    C,F,H--8959080(+) gtggcA/Gtgatc 1 -- ds50018Minor allele frequency- G:0.13NA WA CSA 15
    rs1909359751,2
    C--8959104(+) ACCTCC/TGCTTC 1 -- ds50010--------
    rs29692901,2
    C,F,H--8959163(-) TCCACG/ACCTGT 1 -- ds50013Minor allele frequency- A:0.50NA 6
    rs1426596221,2
    --8959208(+) GAGACA/TGGGTT 1 -- ds50010--------
    rs1460743701,2
    --8959223(+) CAAGTC/TGGCCA 1 -- ds50010--------
    rs1400039221,2
    --8959268(+) CACCCA/GCCTGG 1 -- ds50010--------
    rs1819379681,2
    --8959403(+) TGGTGC/TGAAAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MUC16 (8959520 - 9092018 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MUC16 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718142CNV Deletion23290073
    esv2664410CNV Deletion23128226
    esv2117991CNV Deletion18987734
    esv2718141CNV Deletion23290073
    esv2718144CNV Deletion23290073
    esv2718147CNV Deletion23290073
    dgv621e199CNV Deletion23128226
    esv2718146CNV Deletion23290073
    esv2718143CNV Deletion23290073
    esv2221846CNV Deletion18987734

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MUC16
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606154    OMIM disorders: --

    Selected diseases for MUC16 (see all 29):    
    About MalaCards
    pseudo-meigs syndrome    meigs syndrome    mucinous ovarian cystadenoma    pleural cancer
    bronchogenic cyst    corpus luteum cyst    catamenial pneumothorax    tuberculous peritonitis
    ovarian mucinous cystadenocarcinoma    ovarian cystadenoma    papillary serous adenocarcinoma    struma ovarii
    miliary tuberculosis    adenofibroma    myxedema    sacrococcygeal teratoma
    mucinous cystadenocarcinoma    pleomorphic rhabdomyosarcoma    atopic keratoconjunctivitis    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for MUC16:
    Ovarian cancer

    Find genes that share disorders with MUC16           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MUC16 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 88.9 345 17643440 (6), 16061277 (6), 19818123 (6), 10475127 (6) (see all 99)
    ovarian carcinoma 85.3 87 12404282 (6), 1965803 (4), 12366659 (4), 12821338 (3) (see all 57)
    ovarian tumor benign 84.1 12 1972127 (3), 10985621 (1), 19662218 (1), 17498784 (1) (see all 10)
    recurrent ovarian cancer 79.7 17 15161704 (4), 12795808 (3), 17227902 (2), 20368726 (2) (see all 9)
    stage ovarian cancer 75.1 15 19818996 (3), 20037204 (3), 19662218 (2), 10402722 (1) (see all 8)
    ascites 72.7 79 12366659 (6), 17641444 (4), 16515612 (3), 10985621 (2) (see all 49)
    cystadenocarcinoma serous 71 12 1506732 (2), 9852392 (2), 8494699 (1), 9329572 (1) (see all 6)
    tumors 68.5 415 9234924 (6), 16880776 (6), 17113137 (5), 16942793 (5) (see all 99)
    adnexal mass 68 6 17335881 (1), 18061248 (1), 17290603 (1), 19899428 (1) (see all 6)
    meigs syndrome 66.6 6 16515612 (3), 15906965 (2), 10192495 (1)

    Genetic Association Database (GAD): MUC16
    Human Genome Epidemiology (HuGE) Navigator: MUC16 (3 documents)

    Export disorders for MUC16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MUC16 gene, integrated from 10 sources (see all 767):
    (articles sorted by number of sources associating them with MUC16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. (PubMed id 11369781)1, 2, 3, 9 Yin B.W.T. and Lloyd K.O. (J. Biol. Chem. 2001)
    2. Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. (PubMed id 12734200)1, 2, 9 Kui Wong N.... Patankar M.S. (J. Biol. Chem. 2003)
    3. Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. (PubMed id 15788735)1, 2, 9 McLemore M.R. and Aouizerat B. (Biol. Res. Nurs. 2005)
    4. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. (PubMed id 14676194)1, 2, 9 Rump A....Miyajima A. (J. Biol. Chem. 2004)
    5. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    6. Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye. (PubMed id 16384952)1, 2 Argueso P.... Gipson I.K. (Invest. Ophthalmol. Vis. Sci. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The CA 125 gene: a newly discovered extension of the glycosylated N- terminal domain doubles the size of this extracellular superstructure. (PubMed id 12218296)1, 2 O'Brien T.J.... Shigemasa K. (Tumor Biol. 2002)
    9. The CA 125 gene: an extracellular superstructure dominated by repeat sequences. (PubMed id 11786729)1, 2 O'Brien T.J....York L. (Tumor Biol. 2001)
    10. CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line. (PubMed id 9276028)2, 9 Fendrick J.L....O'Brien T.J. (Tumor Biol. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94025 HGNC: 15582 Ensembl:ENSG00000181143 euGenes: HUgn94025 ECgene: MUC16
    H-InvDB: MUC16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MUC16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MUC16 Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MUC16 gene:
    Search GeneIP for patents involving MUC16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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