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MUC15 Gene

protein-coding   GIFtS: 47
GCID: GC11M026537

Mucin 15, Cell Surface Associated

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mucin 15, Cell Surface Associated1 2
MUC-152 3
PAS32
PASIII2
mucin-152

External Ids:    HGNC: 149561   Entrez Gene: 1436622   Ensembl: ENSG000001695507   OMIM: 6085665   UniProtKB: Q8N3873   

Export aliases for MUC15 gene to outside databases

Previous GC identifers: GC00U991135 GC11M027355 GC11M026619 GC11M026544 GC11M026277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MUC15 Gene:
MUC15 (mucin 15, cell surface associated) is a protein-coding gene. Diseases associated with MUC15 include papillary thyroid carcinoma, and laryngitis.

UniProtKB/Swiss-Prot: MUC15_HUMAN, Q8N387
Function: May play a role in the cell adhesion to the extracellular matrix




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MUC15 gene promoter:
         SRF   RFX1   SRF (504 AA)   POU6F1 (c2)   FAC1   POU2F1   FOXO4   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMUC15 promoter sequence
   Search Chromatin IP Primers for MUC15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3   Ensembl cytogenetic band:  11p14.2   HGNC cytogenetic band: 11p14.3

MUC15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M026537:  view genomic region     (about GC identifiers)

Start:
26,580,579 bp from pter      End:
26,593,815 bp from pter
Size:
13,237 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MUC15_HUMAN, Q8N387 (See protein sequence)
Recommended Name: Mucin-15 precursor  
Size: 334 amino acids; 36294 Da
Sequence caution: Sequence=AAH20912.2; Type=Erroneous termination; Positions=335; Note=Translated as stop;
Secondary accessions: B3KY00 Q6UWS3 Q8IXI8 Q8WW41
Alternative splicing: 2 isoforms:  Q8N387-1   Q8N387-2   

Explore the universe of human proteins at neXtProt for MUC15: NX_Q8N387

Explore proteomics data for MUC15 at MOPED

Post-translational modifications: 

  • Highly glycosylated (N- and O-linked carbohydrates) (By similarity)1
  • Glycosylation2 at Asn30, Asn61, Asn79, Asn90, Asn148, Asn155, Asn163, Asn218, Asn225

  • See MUC15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128563.1  NP_001128564.1  NP_663625.2  

    ENSEMBL proteins: 
     ENSP00000397339   ENSP00000431983   ENSP00000431945   ENSP00000416753   ENSP00000281268  
    Reactome Protein details: Q8N387

    MUC15 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for MUC15
    Cloud-Clone Corp. CLIAs for MUC15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MUC: Mucins

    ProtoNet protein and cluster: Q8N387


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC15_HUMAN, Q8N387
    Function: May play a role in the cell adhesion to the extracellular matrix

    Phenotypes:
         1 MGI phenotypic allele for Muc15 (no phenotypes)


    MUC15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Muc15tm1Lex for MUC15

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MUC15
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    miRNA
    Products:
        
    miRTarBase miRNAs that target MUC15:
    hsa-mir-335-5p (MIRT017060)

    Block miRNA regulation of human, mouse, rat MUC15 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MUC15:
    hsa-miR-551b* hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidMUC15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MUC15

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    Sino Biological Human cDNA Clone for MUC15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUC15

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUC15_HUMAN, Q8N387: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)
    MUC15_HUMAN, Q8N387: Isoform 2: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    extracellular3
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    MUC15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MUC15 About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for MUC15
        O-linked glycosylation of mucins
    Termination of O-glycan biosynthesis



    MUC15 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MUC15
    Interactions:

        Search GeneGlobe Interaction Network for MUC15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MUC15 (ENSP000004167534) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT10ENSP000002971074STRING: ENSP00000297107
    GALNT11ENSP000003158354STRING: ENSP00000315835
    GALNT12ENSP000003641504STRING: ENSP00000364150
    GALNT13ENSP000003765704STRING: ENSP00000376570
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MUC15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MUC15



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MUC15 gene (3 alternative transcripts): 
    NM_001135091.1  NM_001135092.1  NM_145650.3  

    Unigene Cluster for MUC15:

    Mucin 15, cell surface associated
    Hs.407152  [show with all ESTs]
    Unigene Representative Sequence: NM_001135091
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455601(uc001mqx.3) ENST00000529533 ENST00000527569 ENST00000436318(uc001mqw.3)
    ENST00000281268(uc001mqy.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MUC15 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MUC15:
    hsa-miR-551b* hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidMUC15 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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    OriGene qPCR primer pairs and template standards for MUC15
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MUC15
      QuantiTect SYBR Green Assays in human, mouse, rat MUC15
      QuantiFast Probe-based Assays in human, mouse, rat MUC15

    Additional mRNA sequence: 

    AJ417818.1 AJ507429.1 AK026790.1 AK128337.1 AY358668.1 BC020912.1 BC058007.1 

    3 DOTS entries:

    DT.214133  DT.444808  DT.100745537 

    Selected AceView cDNA sequences (see all 111):

    R69775 AY358668 H01478 CR626511 R78648 BQ025249 AA970503 NM_145650 
    H01577 CF528255 BU630408 R32155 AW573035 AA887182 AA912810 BQ024016 
    AI457650 AA335232 BE326955 CB243657 AW964239 AA329570 AI239951 H12375 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MUC15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MUC15 Expression
    About this image


    MUC15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Thyroid (Endocrine System)
     
     Epidermis (Integumentary System)
     
     Placenta (Extraembryonic Tissues)
    MUC15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MUC15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407152

    UniProtKB/Swiss-Prot: MUC15_HUMAN, Q8N387
    Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood
    leukocyte, bone marrow, lymph node and lung

        Custom PCR Arrays for MUC15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MUC15 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Muc151 , 5 mucin 151, 5 73.92(n)1
    60.42(a)1
      2 (56.75 cM)5
    2693281  NM_172979.21  NP_766567.11 
     1107213405 
    lizard
    (Anolis carolinensis)
    Reptilia MUC156
    mucin 15, cell surface associated
    28(a)
    1 ↔ 1
    GL343240.1(814980-830984)


    ENSEMBL Gene Tree for MUC15 (if available)
    TreeFam Gene Tree for MUC15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for MUC15    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22922901,2,4
    ----see VAR_0193762 mis40--------
    rs157831,2,4
    ----see VAR_0193772 mis40--------
    rs2939791,2,4
    ----see VAR_0504522 mis40--------

    HapMap Linkage Disequilibrium report for MUC15 (26580579 - 26593815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MUC15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv467778CNV Loss19166990
    nsv521916CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MUC15
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608566    OMIM disorders: --

    6 diseases for MUC15:    
    About MalaCards
    papillary thyroid carcinoma    laryngitis    asthma    obesity
    thyroiditis    prostatitis


    MUC15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MUC15

    Export disorders for MUC15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MUC15 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MUC15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of MUC15, a novel cell membrane associated mucin. (PubMed id 12047385)1, 2, 3 Pallesen L.T....Rasmussen J.T. (Eur. J. Biochem. 2002)
    2. Common body mass index-associated variants confer risk of extreme obesity. (PubMed id 19553259)1, 4 Cotsapas C....Daly M.J. (Hum. Mol. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro. (PubMed id 17720698)1, 9 Shyu M.K....Hsieh F.J. (Hum. Reprod. 2007)
    6. MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients. (PubMed id 23933603)1 Wang R.Y....Wang H.Y. (Gastroenterology 2013)
    7. The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma. (PubMed id 22657408)1 Dizier M.H....Demenais F. (J. Allergy Clin. Immunol. 2012)
    8. Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma. (PubMed id 21615302)1 Nam K.H....Park C.S. (Thyroid 2011)
    9. Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of human colon cancer cells. (PubMed id 19520792)1 Huang J....Huang M.C. (Carcinogenesis 2009)
    10. Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. (PubMed id 18834073)1 Samuels T.L....Johnston N. (Ann. Otol. Rhinol. Laryngol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 143662 HGNC: 14956 AceView: MUC15 Ensembl:ENSG00000169550 euGenes: HUgn143662
    ECgene: MUC15 H-InvDB: MUC15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MUC15 Pharmacogenomics, SNPs, Pathways
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MUC15 gene:
    Search GeneIP for patents involving MUC15

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