Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MUC15 Gene

Aliases for MUC15 Gene

  • Mucin 15, Cell Surface Associated 2 3 5
  • MUC-15 3 4
  • PASIII 3
  • PAS3 3

External Ids for MUC15 Gene

Previous GeneCards Identifiers for MUC15 Gene

  • GC00U991135
  • GC11M027355
  • GC11M026619
  • GC11M026544
  • GC11M026277

Summaries for MUC15 Gene

GeneCards Summary for MUC15 Gene

MUC15 (Mucin 15, Cell Surface Associated) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for MUC15 Gene

  • May play a role in the cell adhesion to the extracellular matrix.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC15 Gene

Genomics for MUC15 Gene

Regulatory Elements for MUC15 Gene

Genomic Location for MUC15 Gene

Chromosome:
11
Start:
26,559,032 bp from pter
End:
26,572,268 bp from pter
Size:
13,237 bases
Orientation:
Minus strand

Genomic View for MUC15 Gene

Genes around MUC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC15 Gene

Proteins for MUC15 Gene

  • Protein details for MUC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N387-MUC15_HUMAN
    Recommended name:
    Mucin-15
    Protein Accession:
    Q8N387
    Secondary Accessions:
    • B3KY00
    • E9PII6
    • F8W945
    • Q6UWS3
    • Q8IXI8
    • Q8WW41

    Protein attributes for MUC15 Gene

    Size:
    334 amino acids
    Molecular mass:
    36294 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20912.2; Type=Erroneous termination; Positions=335; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC15 Gene

Proteomics data for MUC15 Gene at MOPED

Post-translational modifications for MUC15 Gene

  • Highly glycosylated (N- and O-linked carbohydrates).
  • Glycosylation at Asn 30, Asn 61, Asn 79, Asn 90, Asn 148, Asn 155, Asn 163, Asn 218, and Asn 225
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC15 Gene

No data available for DME Specific Peptides for MUC15 Gene

Domains & Families for MUC15 Gene

Gene Families for MUC15 Gene

HGNC:

Protein Domains for MUC15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC15: view

No data available for UniProtKB/Swiss-Prot for MUC15 Gene

Function for MUC15 Gene

Molecular function for MUC15 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the cell adhesion to the extracellular matrix.
genes like me logo Genes that share phenotypes with MUC15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MUC15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC15 Gene

Localization for MUC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC15 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC15 Gene COMPARTMENTS Subcellular localization image for MUC15 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for MUC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with MUC15: view

Pathways & Interactions for MUC15 Gene

genes like me logo Genes that share pathways with MUC15: view

Interacting Proteins for MUC15 Gene

Gene Ontology (GO) - Biological Process for MUC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MUC15: view

No data available for SIGNOR curated interactions for MUC15 Gene

Drugs & Compounds for MUC15 Gene

No Compound Related Data Available

Transcripts for MUC15 Gene

Unigene Clusters for MUC15 Gene

Mucin 15, cell surface associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC15 Gene

No ASD Table

Relevant External Links for MUC15 Gene

GeneLoc Exon Structure for
MUC15
ECgene alternative splicing isoforms for
MUC15

Expression for MUC15 Gene

mRNA expression in normal human tissues for MUC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC15 Gene

This gene is overexpressed in Thyroid (x11.6), Minor Salivary Gland (x8.1), Esophagus - Mucosa (x7.8), Skin - Not Sun Exposed (Suprapubic) (x5.5), Skin - Sun Exposed (Lower leg) (x5.3), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for MUC15 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC15 Gene



SOURCE GeneReport for Unigene cluster for MUC15 Gene Hs.407152

mRNA Expression by UniProt/SwissProt for MUC15 Gene

Q8N387-MUC15_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, bone marrow, lymph node and lung.
genes like me logo Genes that share expression patterns with MUC15: view

Protein tissue co-expression partners for MUC15 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MUC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC15 35
  • 99.54 (n)
  • 99.17 (a)
MUC15 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MUC15 36
  • 68 (a)
OneToOne
MUC15 35
  • 78.99 (n)
  • 68.79 (a)
dog
(Canis familiaris)
Mammalia MUC15 35
  • 78.86 (n)
  • 65.65 (a)
MUC15 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Muc15 16
Muc15 36
  • 59 (a)
OneToOne
Muc15 35
  • 73.92 (n)
  • 60.42 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MUC15 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Muc15 35
  • 74.34 (n)
  • 60.91 (a)
lizard
(Anolis carolinensis)
Reptilia MUC15 36
  • 28 (a)
OneToOne
Species with no ortholog for MUC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC15 Gene

ENSEMBL:
Gene Tree for MUC15 (if available)
TreeFam:
Gene Tree for MUC15 (if available)

Paralogs for MUC15 Gene

No data available for Paralogs for MUC15 Gene

Variants for MUC15 Gene

Sequence variations from dbSNP and Humsavar for MUC15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_019376 -
VAR_019377 -
VAR_050452 -

Structural Variations from Database of Genomic Variants (DGV) for MUC15 Gene

Variant ID Type Subtype PubMed ID
nsv467778 CNV Loss 19166990
nsv521916 CNV Loss 19592680

Variation tolerance for MUC15 Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC15 Gene

HapMap Linkage Disequilibrium report
MUC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC15 Gene

Disorders for MUC15 Gene

Relevant External Links for MUC15

Genetic Association Database (GAD)
MUC15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC15

No disorders were found for MUC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MUC15 Gene

Publications for MUC15 Gene

  1. Isolation and characterization of MUC15, a novel cell membrane associated mucin. (PMID: 12047385) Pallesen L.T. … Rasmussen J.T. (Eur. J. Biochem. 2002) 2 3 4 67
  2. Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro. (PMID: 17720698) Shyu M.K. … Hsieh F.J. (Hum. Reprod. 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Correlations of MUC15 overexpression with clinicopathological features and prognosis of glioma. (PMID: 24710941) Yang W.B. … Li C.Y. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2014) 3
  5. MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients. (PMID: 23933603) Wang R.Y. … Wang H.Y. (Gastroenterology 2013) 3

Products for MUC15 Gene

Sources for MUC15 Gene

Back to Top

Content