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Aliases for MUC15 Gene

Aliases for MUC15 Gene

  • Mucin 15, Cell Surface Associated 2 3 5
  • MUC-15 3 4
  • Mucin-15 3
  • PASIII 3
  • PAS3 3

External Ids for MUC15 Gene

Previous GeneCards Identifiers for MUC15 Gene

  • GC00U991135
  • GC11M027355
  • GC11M026619
  • GC11M026544
  • GC11M026277

Summaries for MUC15 Gene

GeneCards Summary for MUC15 Gene

MUC15 (Mucin 15, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC15 include Tn Polyagglutination Syndrome. Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling.

UniProtKB/Swiss-Prot for MUC15 Gene

  • May play a role in the cell adhesion to the extracellular matrix.

Additional gene information for MUC15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC15 Gene

Genomics for MUC15 Gene

GeneHancer (GH) Regulatory Elements for MUC15 Gene

Promoters and enhancers for MUC15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I026572 Promoter/Enhancer 0.8 EPDnew ENCODE 550.8 +0.0 46 0.2 IKZF1 GC11M026565 MUC15 ANO3
GH11I026573 Enhancer 0.7 FANTOM5 ENCODE 595.6 -0.7 -727 0.7 USF1 ZBTB33 MUC15 ANO3 SLC5A12 GC11M026667
GH11I026620 Enhancer 0.7 ENCODE 17.6 -49.6 -49615 2.7 SMARCC1 JUN JUNB DPF2 BATF EP300 IRF4 ZKSCAN1 SP1 JUND MUC15 GC11M026667 ANO3
GH11I026583 Enhancer 0.6 ENCODE 13.1 -11.4 -11402 1 SMARCE1 NFIB CEBPB DPF2 CEBPG EP300 ZNF217 GATA3 CTBP1 MUC15 GC11M026667 ANO3
GH11I026593 Enhancer 0.2 ENCODE 19.3 -21.6 -21576 1.1 MUC15 GC11M026667 ANO3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MUC15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MUC15 gene promoter:

Genomic Locations for MUC15 Gene

Genomic Locations for MUC15 Gene
chr11:26,559,032-26,572,268
(GRCh38/hg38)
Size:
13,237 bases
Orientation:
Minus strand
chr11:26,580,579-26,593,815
(GRCh37/hg19)

Genomic View for MUC15 Gene

Genes around MUC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC15 Gene

Proteins for MUC15 Gene

  • Protein details for MUC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N387-MUC15_HUMAN
    Recommended name:
    Mucin-15
    Protein Accession:
    Q8N387
    Secondary Accessions:
    • B3KY00
    • E9PII6
    • F8W945
    • Q6UWS3
    • Q8IXI8
    • Q8WW41

    Protein attributes for MUC15 Gene

    Size:
    334 amino acids
    Molecular mass:
    36294 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20912.2; Type=Erroneous termination; Positions=335; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC15 Gene

Post-translational modifications for MUC15 Gene

  • Highly glycosylated (N- and O-linked carbohydrates).
  • Glycosylation at isoforms=230, isoforms=261, isoforms=279, isoforms=290, Asn148, Asn155, isoforms=2163, Asn218, and Asn225

No data available for DME Specific Peptides for MUC15 Gene

Domains & Families for MUC15 Gene

Gene Families for MUC15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MUC15 Gene

Suggested Antigen Peptide Sequences for MUC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC15: view

No data available for UniProtKB/Swiss-Prot for MUC15 Gene

Function for MUC15 Gene

Molecular function for MUC15 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the cell adhesion to the extracellular matrix.

Phenotypes From GWAS Catalog for MUC15 Gene

genes like me logo Genes that share phenotypes with MUC15: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC15 Gene

Localization for MUC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC15 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUC15 gene
Compartment Confidence
plasma membrane 5
extracellular 4
golgi apparatus 4
nucleus 1

Gene Ontology (GO) - Cellular Components for MUC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MUC15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUC15 Gene

Pathways & Interactions for MUC15 Gene

genes like me logo Genes that share pathways with MUC15: view

Gene Ontology (GO) - Biological Process for MUC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with MUC15: view

No data available for SIGNOR curated interactions for MUC15 Gene

Drugs & Compounds for MUC15 Gene

No Compound Related Data Available

Transcripts for MUC15 Gene

Unigene Clusters for MUC15 Gene

Mucin 15, cell surface associated:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC15 Gene

No ASD Table

Relevant External Links for MUC15 Gene

GeneLoc Exon Structure for
MUC15
ECgene alternative splicing isoforms for
MUC15

Expression for MUC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC15 Gene

This gene is overexpressed in Thyroid (x11.6), Minor Salivary Gland (x8.1), Esophagus - Mucosa (x7.8), Skin - Not Sun Exposed (Suprapubic) (x5.5), Skin - Sun Exposed (Lower leg) (x5.3), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for MUC15 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC15 Gene



Protein tissue co-expression partners for MUC15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MUC15 Gene:

MUC15

SOURCE GeneReport for Unigene cluster for MUC15 Gene:

Hs.407152

mRNA Expression by UniProt/SwissProt for MUC15 Gene:

Q8N387-MUC15_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, bone marrow, lymph node and lung.

Evidence on tissue expression from TISSUES for MUC15 Gene

  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with MUC15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC15 Gene

Orthologs for MUC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC15 33 34
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia MUC15 33 34
  • 78.99 (n)
dog
(Canis familiaris)
Mammalia MUC15 33 34
  • 78.86 (n)
rat
(Rattus norvegicus)
Mammalia Muc15 33
  • 74.34 (n)
mouse
(Mus musculus)
Mammalia Muc15 33 16 34
  • 73.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MUC15 34
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MUC15 34
  • 28 (a)
OneToOne
Species where no ortholog for MUC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC15 Gene

ENSEMBL:
Gene Tree for MUC15 (if available)
TreeFam:
Gene Tree for MUC15 (if available)

Paralogs for MUC15 Gene

No data available for Paralogs for MUC15 Gene

Variants for MUC15 Gene

Sequence variations from dbSNP and Humsavar for MUC15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs293979 likely-benign, not provided 26,565,803(-) G/A/C coding_sequence_variant, missense_variant
rs1000110379 -- 26,570,764(-) G/A intron_variant
rs1000115096 -- 26,563,383(-) G/A intron_variant
rs1001055014 -- 26,569,064(-) A/G intron_variant
rs1001067488 -- 26,559,022(-) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MUC15 Gene

Variant ID Type Subtype PubMed ID
esv3579450 CNV loss 25503493
esv3891956 CNV loss 25118596
nsv1051211 CNV loss 25217958
nsv467778 CNV loss 19166990
nsv521916 CNV loss 19592680
nsv553899 CNV loss 21841781

Variation tolerance for MUC15 Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MUC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MUC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC15 Gene

Disorders for MUC15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MUC15 Gene - From: GeneCards

Disorder Aliases PubMed IDs
tn polyagglutination syndrome
  • tnps
- elite association - COSMIC cancer census association via MalaCards
Search MUC15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MUC15

genes like me logo Genes that share disorders with MUC15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC15 Gene

Publications for MUC15 Gene

  1. Isolation and characterization of MUC15, a novel cell membrane-associated mucin. (PMID: 12047385) Pallesen LT … Rasmussen JT (European journal of biochemistry 2002) 2 3 4 58
  2. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C … GIANT Consortium (Human molecular genetics 2009) 3 44 58
  3. Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro. (PMID: 17720698) Shyu MK … Hsieh FJ (Human reproduction (Oxford, England) 2007) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for MUC15 Gene

Sources for MUC15 Gene

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