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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MUC15 Gene

protein-coding   GIFtS: 43
GCID: GC11M026537

mucin 15, cell surface associated
 Explore 7 diseases affiliated with
MUC15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MUC15    

Aliases
for MUC15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mucin 15, Cell Surface Associated1 2
MUC-152 3
PAS32
PASIII2
Mucin-151

External Ids:    HGNC: 149561   Entrez Gene: 1436622   Ensembl: ENSG000001695507   OMIM: 6085665   UniProtKB: Q8N3873   

Export aliases for MUC15 gene to outside databases

Previous GC identifers: GC00U991135 GC11M027355 GC11M026619 GC11M026544 GC11M026277


Summaries
for MUC15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MUC15_HUMAN, Q8N387
Function: May play a role in the cell adhesion to the extracellular matrix




Genomic Views
for MUC15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MUC15 gene promoter:
         SRF   RFX1   SRF (504 AA)   POU6F1 (c2)   FAC1   POU2F1   FOXO4   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MUC15 promoter sequence
   Search SABiosciences Chromatin IP Primers for MUC15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3   Ensembl cytogenetic band:  11p14.2   HGNC cytogenetic band: 11p14.3

MUC15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M026537:  view genomic region     (about GC identifiers)

Start:
 26,580,579 bp from pter      End:
 26,593,815 bp from pter
Size:
 13,237 bases      Orientation:
 minus strand

Proteins
for MUC15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MUC15_HUMAN, Q8N387 (See protein sequence)
Recommended Name: Mucin-15 precursor  
Size: 334 amino acids; 36294 Da
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 2: Secreted (Potential)
Sequence caution: Sequence=AAH20912.2; Type=Erroneous termination; Positions=335; Note=Translated as stop;
Secondary accessions: B3KY00 Q6UWS3 Q8IXI8 Q8WW41
Alternative splicing: 2 isoforms:  Q8N387-1   Q8N387-2   

Explore the universe of human proteins at neXtProt for MUC15: NX_Q8N387

Post-translational modifications:

  • Highly glycosylated (N- and O-linked carbohydrates) (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N387

    • MUC15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128563.1  NP_001128564.1  NP_663625.2  

    ENSEMBL proteins: 
     ENSP00000397339   ENSP00000431983   ENSP00000431945   ENSP00000416753   ENSP00000281268  
    Reactome Protein details: Q8N387
    Human Recombinant Protein Products: 
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    Uscn Proteins for MUC15

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    MUC15 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MUC15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N387


    Function
    for MUC15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MUC15_HUMAN, Q8N387
    Function: May play a role in the cell adhesion to the extracellular matrix

    miRNA
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    Inhib. RNA
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    Clone
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    In Situ Assay
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    Animal Models:
         Mouse knock-out Muc15tm1Lex for MUC15
         1 MGI phenotypic allele for Muc15 (no phenotypes)

    MUC15 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MUC15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    		Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein1.00
    		Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein1.00
    		Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein1.00
    		Termination of O-glycan biosynthesis0.69
    		Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein1.00
    		O-linked glycosylation of mucins0.28
    2Asparagine N-linked glycosylation
    		Post-translational protein modification0.44
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for MUC15 (see all 8)
        Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein



    MUC15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUC15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for MUC15 (ENSP000004167534) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT10ENSP000002971074STRING: ENSP00000297107
    GALNT14ENSP000002889884STRING: ENSP00000288988
    GALNT15ENSP000003442604STRING: ENSP00000344260
    GCNT1ENSP000003659204STRING: ENSP00000365920
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    MUC15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MUC15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MUC15
    Search CenterWatch for drugs/clinical trials and news about MUC15 

    Transcripts
    for MUC15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MUC15 gene (3 alternative transcripts): 
    NM_001135091.1  NM_001135092.1  NM_145650.3  

    Unigene Cluster for MUC15:

    Mucin 15, cell surface associated
    Hs.407152  [show with all ESTs]
    Unigene Representative Sequence: NM_001135091
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455601(uc001mqx.3) ENST00000529533 ENST00000527569 ENST00000436318(uc001mqw.3)
    ENST00000281268(uc001mqy.3)

    miRNA
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    hsa-miR-551b* hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmid: MUC15 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ417818.1 AJ507429.1 AK026790.1 AK128337.1 AY358668.1 BC020912.1 BC058007.1 

    3 DOTS entries:

    DT.214133  DT.444808  DT.100745537 

    24/111 AceView cDNA sequences (see all 111):

    R69775 AI580282 AW964239 R32155 AA335232 H01478 AA912810 AY358668 
    AA970503 AI457650 AW573035 AI743944 CF528255 H01577 AA887182 AA329570 
    AI239951 BQ025249 R78648 BQ024016 BM981007 BU630408 BE326955 CB243657 

    GeneLoc Exon Structure


    Expression
    for MUC15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MUC15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MUC15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MUC15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MUC15

    SOURCE GeneReport for Unigene cluster: Hs.407152

    UniProtKB/Swiss-Prot: MUC15_HUMAN, Q8N387
    Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood
    leukocyte, bone marrow, lymph node and lung

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC15

    Orthologs
    for MUC15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MUC15 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Muc151 , 5 mucin 151, 5 73.78(n)1
    61.28(a)1    		   2 (56.75 cM)5
    2693281  NM_172979.21  NP_766567.11 
     1107213405 
    lizard
    (Anolis carolinensis)    		 Reptilia MUC156
    		 --
    		 44(a)
    		 1 ↔ 1
    		 GL343240.1(816023-821020)


    ENSEMBL Gene Tree for MUC15 (if available)
    TreeFam Gene Tree for MUC15 (if available) 

    Paralogs
    for MUC15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MUC15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC15
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC15

    Disorders / Diseases
    for MUC15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MUC15 for disorders           About GeneDecksing

    OMIM gene information: 608566    OMIM disorders: --

    7 diseases for MUC15:    About MalaCards
    papillary thyroid carcinoma    thyroid carcinoma    thyroiditis    laryngitis
    obesity    carcinoma    prostatitis


    Export disorders for MUC15 gene to outside databases

    Publications
    for MUC15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MUC15 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MUC15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of MUC15, a novel cell membrane associated mucin. (PubMed id 12047385)1, 2, 3 Pallesen L.T....Rasmussen J.T. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro. (PubMed id 17720698)1, 9 Shyu M.K....Hsieh F.J. (2007)
    5. The ANO3/MUC15 locus is associated with eczema in fami lies ascertained through asthma. (PubMed id 22657408)1 Dizier M.H....Demenais F. (2012)
    6. Expression of the membrane mucins MUC4 and MUC15, pot ential markers of malignancy and prognosis, in papillary thyroid carcinoma. (PubMed id 21615302)1 Nam K.H....Park C.S. (2011)
    7. Common body mass index-associated variants confer ris k of extreme obesity. (PubMed id 19553259)1 Cotsapas C....Daly M.J. (2009)
    8. Overexpression of MUC15 activates extracellular signa l-regulated kinase 1/2 and promotes the oncogenic potential of human colon canc er cells. (PubMed id 19520792)1 Huang J....Huang M.C. (2009)
    9. Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. (PubMed id 18834073)1 Samuels T.L....Johnston N. (2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    External Searches for MUC15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MUC15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 143662 HGNC: 14956 AceView: MUC15 Ensembl:ENSG00000169550 euGenes: HUgn143662
    ECgene: MUC15 H-InvDB: MUC15

    Other Databases showing MUC15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MUC15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MUC15 Pharmacogenomics, SNPs, Pathways
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    Intellectual Property
    for MUC15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MUC15 gene:
    Search GeneIP for patents involving MUC15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MUC15 gene

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    In Situ Hybridization Assays from
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