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Aliases for MUC15 Gene

Aliases for MUC15 Gene

  • Mucin 15, Cell Surface Associated 2 3
  • MUC-15 3 4
  • Mucin-15 3
  • PASIII 3
  • PAS3 3

External Ids for MUC15 Gene

Previous GeneCards Identifiers for MUC15 Gene

  • GC00U991135
  • GC11M027355
  • GC11M026619
  • GC11M026544
  • GC11M026277

Summaries for MUC15 Gene

UniProtKB/Swiss-Prot for MUC15 Gene

  • May play a role in the cell adhesion to the extracellular matrix

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC15 Gene

Genomics for MUC15 Gene

Regulatory Elements for MUC15 Gene

Genomic Location for MUC15 Gene

Start:
26,559,032 bp from pter
End:
26,572,268 bp from pter
Size:
13,237 bases
Orientation:
Minus strand

Genomic View for MUC15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC15 Gene

Proteins for MUC15 Gene

  • Protein details for MUC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N387-MUC15_HUMAN
    Recommended name:
    Mucin-15
    Protein Accession:
    Q8N387
    Secondary Accessions:
    • B3KY00
    • E9PII6
    • F8W945
    • Q6UWS3
    • Q8IXI8
    • Q8WW41

    Protein attributes for MUC15 Gene

    Size:
    334 amino acids
    Molecular mass:
    36294 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20912.2; Type=Erroneous termination; Positions=335; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC15 Gene

Proteomics data for MUC15 Gene at MOPED

Post-translational modifications for MUC15 Gene

  • Highly glycosylated (N- and O-linked carbohydrates).
  • Glycosylation at Asn30, Asn61, Asn79, Asn90, Asn148, Asn155, Asn163, Asn218, and Asn225
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC15 Gene

No data available for DME Specific Peptides for MUC15 Gene

Domains for MUC15 Gene

Gene Families for MUC15 Gene

HGNC:

Protein Domains for MUC15 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MUC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC15: view

No data available for UniProtKB/Swiss-Prot for MUC15 Gene

Function for MUC15 Gene

Molecular function for MUC15 Gene

UniProtKB/Swiss-Prot Function: May play a role in the cell adhesion to the extracellular matrix

Animal Model Products

CRISPR Products

miRNA for MUC15 Gene

miRTarBase miRNAs that target MUC15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MUC15 Gene

Localization for MUC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC15 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC15 Gene COMPARTMENTS Subcellular localization image for MUC15 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for MUC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MUC15: view

Pathways for MUC15 Gene

genes like me logo Genes that share pathways with MUC15: view

Interacting Proteins for MUC15 Gene

Gene Ontology (GO) - Biological Process for MUC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC15: view

Transcripts for MUC15 Gene

Unigene Clusters for MUC15 Gene

Mucin 15, cell surface associated:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MUC15

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC15 Gene

No ASD Table

Relevant External Links for MUC15 Gene

GeneLoc Exon Structure for
MUC15
ECgene alternative splicing isoforms for
MUC15

Expression for MUC15 Gene

mRNA expression in normal human tissues for MUC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC15 Gene

This gene is overexpressed in Thyroid (11.6), Minor Salivary Gland (8.1), Esophagus - Mucosa (7.8), Skin - Not Sun Exposed (Suprapubic) (5.5), Skin - Sun Exposed (Lower leg) (5.3), and Vagina (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MUC15 Gene

SOURCE GeneReport for Unigene cluster for MUC15 Gene Hs.407152

mRNA Expression by UniProt/SwissProt for MUC15 Gene

Q8N387-MUC15_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, bone marrow, lymph node and lung.
genes like me logo Genes that share expressions with MUC15: view

In Situ Assay Products

Orthologs for MUC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC15 35
  • 99.54 (n)
  • 99.17 (a)
MUC15 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MUC15 35
  • 78.99 (n)
  • 68.79 (a)
MUC15 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MUC15 35
  • 78.86 (n)
  • 65.65 (a)
MUC15 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Muc15 35
  • 73.92 (n)
  • 60.42 (a)
Muc15 16
Muc15 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUC15 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Muc15 35
  • 74.34 (n)
  • 60.91 (a)
lizard
(Anolis carolinensis)
Reptilia MUC15 36
  • 28 (a)
OneToOne
Species with no ortholog for MUC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC15 Gene

ENSEMBL:
Gene Tree for MUC15 (if available)
TreeFam:
Gene Tree for MUC15 (if available)

Paralogs for MUC15 Gene

No data available for Paralogs for MUC15 Gene

Variants for MUC15 Gene

Sequence variations from dbSNP and Humsavar for MUC15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_019376 -
VAR_019377 -
VAR_050452 -

Structural Variations from Database of Genomic Variants (DGV) for MUC15 Gene

Variant ID Type Subtype PubMed ID
nsv467778 CNV Loss 19166990
nsv521916 CNV Loss 19592680

Relevant External Links for MUC15 Gene

HapMap Linkage Disequilibrium report
MUC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC15 Gene

Disorders for MUC15 Gene

Relevant External Links for MUC15

Genetic Association Database (GAD)
MUC15
genes like me logo Genes that share disorders with MUC15: view

No data available for UniProtKB/Swiss-Prot for MUC15 Gene

Publications for MUC15 Gene

  1. Isolation and characterization of MUC15, a novel cell membrane associated mucin. (PMID: 12047385) Pallesen L.T. … Rasmussen J.T. (Eur. J. Biochem. 2002) 2 3 4
  2. Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro. (PMID: 17720698) Shyu M.K. … Hsieh F.J. (Hum. Reprod. 2007) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C. … Daly M.J. (Hum. Mol. Genet. 2009) 3 48

Products for MUC15 Gene

Sources for MUC15 Gene

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