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Aliases for MUC13 Gene

Aliases for MUC13 Gene

  • Mucin 13, Cell Surface Associated 2 3 5
  • Down-Regulated In Colon Cancer 1 2 3 4
  • Mucin 13, Epithelial Transmembrane 2 3
  • MUC-13 3 4
  • DRCC1 3 4
  • RECC 4

External Ids for MUC13 Gene

Previous HGNC Symbols for MUC13 Gene

  • DRCC1

Previous GeneCards Identifiers for MUC13 Gene

  • GC03P186200
  • GC03M124651
  • GC03M125905
  • GC03M125946
  • GC03M125947
  • GC03M126106
  • GC03M121998
  • GC03M124624

Summaries for MUC13 Gene

Entrez Gene Summary for MUC13 Gene

  • Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008]

GeneCards Summary for MUC13 Gene

MUC13 (Mucin 13, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC13 include Purulent Endophthalmitis and Relapsing Fever. Among its related pathways are Diseases associated with O-glycosylation of proteins and Defective GALNT12 causes colorectal cancer 1 (CRCS1). GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for MUC13 Gene

  • Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC13 Gene

Genomics for MUC13 Gene

Regulatory Elements for MUC13 Gene

Enhancers for MUC13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MUC13 on UCSC Golden Path with GeneCards custom track

Genomic Location for MUC13 Gene

124,905,442 bp from pter
124,953,819 bp from pter
48,378 bases
Minus strand

Genomic View for MUC13 Gene

Genes around MUC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC13 Gene

Proteins for MUC13 Gene

  • Protein details for MUC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UWD9
    • Q9NXT5

    Protein attributes for MUC13 Gene

    512 amino acids
    Molecular mass:
    54604 Da
    Quaternary structure:
    • Homodimer of beta subunits.
    • Sequence=BAA90925.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MUC13 Gene

Proteomics data for MUC13 Gene at MOPED

Post-translational modifications for MUC13 Gene

  • Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds.
  • Highly N-glycosylated.
  • Glycosylation at Asn 151, Asn 169, Asn 193, Asn 206, Asn 284, and Asn 332
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MUC13 Gene

Domains & Families for MUC13 Gene

Gene Families for MUC13 Gene


Protein Domains for MUC13 Gene

Suggested Antigen Peptide Sequences for MUC13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EGF-like domains.
  • Contains 3 EGF-like domains.
  • Contains 1 SEA domain.
genes like me logo Genes that share domains with MUC13: view

Function for MUC13 Gene

Molecular function for MUC13 Gene

UniProtKB/Swiss-Prot Function:
Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

Animal Model Products

  • Taconic Biosciences Mouse Models for MUC13

miRNA for MUC13 Gene

miRTarBase miRNAs that target MUC13

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC13 Gene

Localization for MUC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC13 Gene

Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Secreted. Note=Also exists as a soluble form.

Subcellular locations from

Jensen Localization Image for MUC13 Gene COMPARTMENTS Subcellular localization image for MUC13 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
golgi apparatus 4
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MUC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0005829 cytosol IMP 11278439
genes like me logo Genes that share ontologies with MUC13: view

Pathways & Interactions for MUC13 Gene

genes like me logo Genes that share pathways with MUC13: view

Interacting Proteins for MUC13 Gene

Selected Interacting proteins: Q9H3R2-MUC13_HUMAN for MUC13 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MUC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030277 maintenance of gastrointestinal epithelium IMP 17058067
genes like me logo Genes that share ontologies with MUC13: view

No data available for SIGNOR curated interactions for MUC13 Gene

Drugs & Compounds for MUC13 Gene

No Compound Related Data Available

Transcripts for MUC13 Gene

Unigene Clusters for MUC13 Gene

Mucin 13, cell surface associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC13 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - - - -
SP3: -

Relevant External Links for MUC13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC13 Gene

mRNA expression in normal human tissues for MUC13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC13 Gene

This gene is overexpressed in Colon - Transverse (x25.4) and Small Intestine - Terminal Ileum (x22.7).

Protein differential expression in normal tissues from HIPED for MUC13 Gene

This gene is overexpressed in Fetal gut (38.9), Islet of Langerhans (14.5), and Pancreatic juice (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MUC13 Gene

SOURCE GeneReport for Unigene cluster for MUC13 Gene Hs.5940

mRNA Expression by UniProt/SwissProt for MUC13 Gene

Tissue specificity: Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.
genes like me logo Genes that share expression patterns with MUC13: view

Protein tissue co-expression partners for MUC13 Gene

- Elite partner

Primer Products

Orthologs for MUC13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MUC13 35
  • 70.11 (n)
  • 57.88 (a)
MUC13 36
  • 47 (a)
(Mus musculus)
Mammalia Muc13 35
  • 59.39 (n)
  • 46.78 (a)
Muc13 16
Muc13 36
  • 35 (a)
(Pan troglodytes)
Mammalia MUC13 35
  • 99.06 (n)
  • 97.98 (a)
MUC13 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Muc13 35
  • 59.96 (n)
  • 46.61 (a)
(Canis familiaris)
Mammalia MUC13 36
  • 42 (a)
(Monodelphis domestica)
Mammalia MUC13 36
  • 27 (a)
(Gallus gallus)
Aves MUC13 36
  • 21 (a)
(Anolis carolinensis)
Reptilia MUC13 36
  • 21 (a)
Species with no ortholog for MUC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC13 Gene

Gene Tree for MUC13 (if available)
Gene Tree for MUC13 (if available)

Paralogs for MUC13 Gene

No data available for Paralogs for MUC13 Gene

Variants for MUC13 Gene

Sequence variations from dbSNP and Humsavar for MUC13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4679394 - 124,927,993(+) TGGTG(A/C/G)CTGGA reference, missense
rs16836185 - 124,913,235(+) GAGAC(C/T)GGAAG reference, missense
rs1127233 - 124,908,177(-) TCAAG(A/C)CACAG reference, missense
rs4679392 - 124,927,747(+) TAGGT(A/G)TAGGA reference, missense
rs12732 -- 124,905,721(-) AGCCG(C/T)CCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MUC13 Gene

Variant ID Type Subtype PubMed ID
nsv877403 CNV Loss 21882294
nsv877404 CNV Loss 21882294
esv1366339 CNV Insertion 17803354
nsv818166 CNV Loss 17921354

Variation tolerance for MUC13 Gene

Gene Damage Index Score: 5.06; 68.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC13 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC13 Gene

Disorders for MUC13 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MUC13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
purulent endophthalmitis
relapsing fever
- elite association - COSMIC cancer census association via MalaCards
Search MUC13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MUC13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC13 Gene

Publications for MUC13 Gene

  1. Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. (PMID: 11278439) Williams S.J. … McGuckin M.A. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection. (PMID: 25261323) van den Kieboom C.H. … de Jonge M.I. (Eur. Respir. J. 2015) 3
  3. A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells. (PMID: 25672256) Nishii Y. … Sakuma Y. (Int. J. Oncol. 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Overexpression of mucin 13 due to promoter methylation promotes aggressive behavior in ovarian cancer cells. (PMID: 25048476) Sung H.Y. … Ahn J.H. (Yonsei Med. J. 2014) 3

Products for MUC13 Gene

Sources for MUC13 Gene