Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MUC12 Gene

Aliases for MUC12 Gene

  • Mucin 12, Cell Surface Associated 2 3
  • MUC11 3 4 6
  • Mucin 11 2 3
  • Mucin-11 3 4
  • MUC-11 3 4
  • MUC-12 3 4
  • Mucin-12 3

External Ids for MUC12 Gene

Previous Symbols for MUC12 Gene

  • MUC11

Summaries for MUC12 Gene

GeneCards Summary for MUC12 Gene

MUC12 (Mucin 12, Cell Surface Associated) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. An important paralog of this gene is MUC17.

UniProtKB/Swiss-Prot for MUC12 Gene

  • Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC12 Gene

Genomics for MUC12 Gene

Genomic Location for MUC12 Gene

Start:
100,969,623 bp from pter
End:
101,018,949 bp from pter
Size:
49,327 bases
Orientation:
Plus strand

Genomic View for MUC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC12 Gene

No data available for Regulatory Elements for MUC12 Gene

Proteins for MUC12 Gene

  • Protein details for MUC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKN1-MUC12_HUMAN
    Recommended name:
    Mucin-12
    Protein Accession:
    Q9UKN1
    Secondary Accessions:
    • A6ND38
    • F5GWV9
    • Q9UKN0

    Protein attributes for MUC12 Gene

    Size:
    5478 amino acids
    Molecular mass:
    558164 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Infection by L.monocytogenes induces increases in mucin secretion and MUC4 and MUC12 transcription. This may constitute a host cell defense response that inhibits the entry of listeria monocytogenes in the cell

    Alternative splice isoforms for MUC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUC12 Gene

Proteomics data for MUC12 Gene at MOPED

Post-translational modifications for MUC12 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn154, Asn170, Asn176, Asn382, Asn738, Asn1793, Asn3350, Asn4433, Asn4571, Asn5169, Asn5182, Asn5197, Asn5228, and Asn5264

Other Protein References for MUC12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC12 Gene

Domains for MUC12 Gene

Gene Families for MUC12 Gene

HGNC:

Protein Domains for MUC12 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MUC12_HUMAN
Domain:
  • The proteolytic cleavage occurs within the SEA domain. This domain is not interchangeable, suggesting that it is insufficient to mediate efficient cleavage.:
    • Q9UKN1
  • Contains 1 EGF-like domain.:
    • Q9UKN1
  • Contains 1 SEA domain.:
    • Q9UKN1
genes like me logo Genes that share domains with MUC12: view

Function for MUC12 Gene

Molecular function for MUC12 Gene

GENATLAS Biochemistry: mucin 12,cell surface glycoprotein,expressed in colon,down-regulated in colorectal cancer,maybe involved in epithelial cell regulation
UniProtKB/Swiss-Prot Function: Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium.
UniProtKB/Swiss-Prot Induction: By listeriolysin O.

Gene Ontology (GO) - Molecular Function for MUC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MUC12: view

Phenotypes for MUC12 Gene

GenomeRNAi human phenotypes for MUC12:
genes like me logo Genes that share phenotypes with MUC12: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MUC12 Gene

Localization for MUC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC12 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC12 Gene COMPARTMENTS Subcellular localization image for MUC12 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
cytosol 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MUC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0005887 integral component of plasma membrane NAS 10463611
genes like me logo Genes that share ontologies with MUC12: view

Pathways for MUC12 Gene

genes like me logo Genes that share pathways with MUC12: view

Gene Ontology (GO) - Biological Process for MUC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10463611
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC12: view

Transcripts for MUC12 Gene

Unigene Clusters for MUC12 Gene

Mucin 12, cell surface associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC12 Gene

No ASD Table

Relevant External Links for MUC12 Gene

GeneLoc Exon Structure for
MUC12
ECgene alternative splicing isoforms for
MUC12

Expression for MUC12 Gene

mRNA expression in normal human tissues for MUC12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC12 Gene

This gene is overexpressed in Colon - Transverse (39.5), Colon - Sigmoid (5.4), and Prostate (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MUC12 Gene

SOURCE GeneReport for Unigene cluster for MUC12 Gene Hs.489355

mRNA Expression by UniProt/SwissProt for MUC12 Gene

Q9UKN1-MUC12_HUMAN
Tissue specificity: Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in the colon of patients with ulcerative colitis (UC) and Crohns disease (CD).
genes like me logo Genes that share expressions with MUC12: view

Orthologs for MUC12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC12 37
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MUC12 37
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 27 (a)
ManyToMany
Species with no ortholog for MUC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC12 Gene

ENSEMBL:
Gene Tree for MUC12 (if available)
TreeFam:
Gene Tree for MUC12 (if available)

Paralogs for MUC12 Gene

Paralogs for MUC12 Gene

Selected SIMAP similar genes for MUC12 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MUC12: view

Variants for MUC12 Gene

Sequence variations from dbSNP and Humsavar for MUC12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1790 -- 100,991,418(-) GTGTC(C/G/T)TTTGA synonymous-codon, missense, reference
rs1791 -- 100,991,359(-) GCTGG(A/C/T)AGGGG missense, reference
rs3891963 -- 100,987,966(-) tagac(A/G)tagtt intron-variant
rs3892290 -- 100,968,857(-) GGCAG(A/C/G)CCTGA upstream-variant-2KB
rs3924886 -- 101,012,722(-) CTCCC(C/G)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MUC12 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv2119e1 CNV Complex 17122850
dgv2120e1 CNV Complex 17122850
nsv428181 CNV Gain+Loss 18775914
nsv831074 CNV Loss 17160897
nsv511981 CNV Loss 21212237
esv2734907 CNV Deletion 23290073
nsv513678 OTHER Inversion 21212237
nsv5871 CNV Insertion 18451855
nsv7 CNV Insertion 15895083
nsv820330 CNV Duplication 20802225
esv1007842 CNV Insertion 20482838
esv24638 CNV Gain+Loss 19812545
nsv824240 CNV Gain 20364138
nsv8187 CNV Gain+Loss 18304495
dgv1154e201 CNV Deletion 23290073
esv2667109 CNV Deletion 23128226
dgv1155e201 CNV Deletion 23290073
esv1426303 CNV Deletion 17803354
nsv5872 CNV Insertion 18451855
nsv8 CNV Insertion 15895083

Relevant External Links for MUC12 Gene

HapMap Linkage Disequilibrium report
MUC12

Disorders for MUC12 Gene

(2) Novoseek inferred disease relationships for MUC12 Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 40.4 1
tumors 0 2
genes like me logo Genes that share disorders with MUC12: view

No data available for UniProtKB/Swiss-Prot for MUC12 Gene

Publications for MUC12 Gene

  1. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. (PMID: 10463611) Williams S.J. … Antalis T.M. (Cancer Res. 1999) 2 3 4 23
  2. Mucin gene expression in the effusions of otitis media with effusion. (PMID: 12560150) Takeuchi K. … Majima Y. (Int. J. Pediatr. Otorhinolaryngol. 2003) 23
  3. Expression of the cell surface mucin gene family in adenocarcinomas. (PMID: 15375564) Packer L.M. … McGuckin M.A. (Int. J. Oncol. 2004) 23
  4. Peritoneal recurrence of gastric cancer with mucin phenotype 12 years after curative resection: report of a case. (PMID: 17387567) Aihara R. … Suzuki K. (Surg. Today 2007) 23
  5. Mucin gene expression in human middle ear epithelium. (PMID: 17667140) Kerschner J.E. (Laryngoscope 2007) 23

Products for MUC12 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MUC12
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MUC12
    • Block miRNA regulation of MUC12 using miScript Target Protectors

    Sources for MUC12 Gene

    Back to Top

    Content