MUC12 Gene
protein-coding GIFtS: 48
GCID: GC07P100612
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|
mucin 12, cell surface associated(Previous name: mucin 11 )
(Previous symbol: MUC11)
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Aliases
for MUC12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mucin 12, Cell Surface Associated1 2 | | MUC-122 3 | | MUC111 2 3 5 | | Mucin-113 | | Mucin 111 2 | | Mucin-121 | | MUC-112 3 | | Mucin-113 |
Export aliases for MUC12 gene to outside databasesPrevious GC identifers: GC07P099131 GC07P100194 GC07P100208 GC07P100240 GC07P100429 GC07P095191 |
Summaries
for MUC12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MUC12_HUMAN, Q9UKN1Function: Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelialcell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium
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Genomic Views
for MUC12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MUC12
Other transcription factors
Search SABiosciences Chromatin IP Primers for MUC12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22MUC12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P100612: view genomic region
(about GC identifiers)
Start:
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100,612,904 bp from pter |
End:
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100,662,230 bp from pter |
Size:
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49,327 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,971,293-100,020,619 |
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Proteins
for MUC12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MUC12_HUMAN, Q9UKN1 (See
protein sequence)Recommended Name: Mucin-12 precursor Size: 5478 amino acids; 558164 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Miscellaneous: Infection by L.monocytogenes induces increases in mucin secretion and MUC4 and MUC12 transcription. Thismay constitute a host cell defense response that inhibits the entry of listeria monocytogenes in the cell
Secondary accessions: A6ND38 Q9UKN0Explore the universe of human proteins at neXtProt for MUC12: NX_Q9UKN1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKN1
MUC12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001157934.1
ENSEMBL proteins: ENSP00000368755 ENSP00000306919 ENSP00000441929 Reactome Protein details: Q9UKN1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MUC12 for ontologies About GeneDecksing
MUC12 Antibody Products:
Assay Products for MUC12: |
Protein
Domains /
Families
for MUC12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MUC12 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKN1ProtoNet protein and cluster: Q9UKN1 1 Blocks protein family: IPB000082 SEA domain
UniProtKB/Swiss-Prot: MUC12_HUMAN, Q9UKN1Domain: The proteolytic cleavage occurs within the SEA domain. This domain is not interchangeable, suggesting that itis insufficient to mediate efficient cleavageSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 SEA domain |
Function
for MUC12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MUC12_HUMAN, Q9UKN1Function: Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelialcell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epitheliumInduction: By listeriolysin O Genatlas biochemistry entry for MUC12:mucin 12,cell surface glycoprotein,expressed in colon,down-regulated in colorectal cancer,maybe involved in epithelialcell regulation
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC12 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
MUC12 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MUC12:
|
Pathways & Interactions
for MUC12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for MUC12 (see all 8)
MUC12 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUC12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/47 Interacting proteins for MUC12 (Q9UKN13 ENSP000003687554) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
MUC12 for ontologies About GeneDecksing
|
Drugs & Compounds
for MUC12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MUC12
Search CenterWatch for drugs/clinical trials and news about MUC12
|
Transcripts
for MUC12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MUC12 gene: NM_001164462.1 Unigene Cluster for MUC12: Mucin 12, cell surface associated Hs.489355 [show with all ESTs]Unigene Representative Sequence: NM_0011644626 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379442 ENST00000305119 ENST00000473098 ENST00000467414 ENST00000474482
ENST00000536621(uc003uxo.3)
Additional cDNA sequence: AF147790.1 AF147791.1 AK024856.1 AK025404.1 AK130455.1 AK296627.1 BC127877.1 BC152481.1 BC152482.1 24/31 DOTS entries (see all 31): DT.95151723 DT.86855004 DT.86846562 DT.95364743 DT.97859163 DT.435400 DT.95121454 DT.91690847 DT.95264785 DT.91918837 DT.95362898 DT.100743021 DT.100811954 DT.91734436 DT.95309254 DT.121071776 DT.92440543 DT.95070709 DT.95332859 DT.95358994 DT.100036266 DT.100811955 DT.121071780 DT.121071790 24/216 AceView cDNA sequences (see all 216): BG959491 AI732436 BQ719224 AF147790 BM987949 BX104713 BG982489 AW849376 AW849507 AW849669 AI763064 BG982490 BE927962 BG956076 AW843883 BE550265 BG983049 AI954628 BF804409 AW938895 AI342785 BF768293 AW572433 BG978643
GeneLoc Exon Structure
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Expression
for MUC12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MUC12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGCTGCAA
About this image
See MUC12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MUC12
SOURCE GeneReport for Unigene cluster: Hs.489355
UniProtKB/Swiss-Prot: MUC12_HUMAN, Q9UKN1Tissue specificity: Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in thecolon of patients with ulcerative colitis (UC) and Crohn's disease (CD)
SABiosciences Custom PCR Arrays for MUC12
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MUC12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC12 |
Orthologs
for MUC12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MUC12 gene from 3/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5663631 |
mucin-17-like |
42.11(n)
34.85(a) |
|
566363 XM_701288.4 XP_706380.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sgs16 |
Salivary gland secretion 1 |
17(a) |
1 ↔ 1 |
2L(4937409-4941424) |
worm
(Caenorhabditis elegans) |
Secernentea |
F26C11.36 |
Uncharacterized protein F26C11.3 |
7(a) |
possible ortholog |
II(9903000-9915040) |
ENSEMBL Gene Tree for MUC12 (if available)
TreeFam Gene Tree for MUC12 (if available) |
Paralogs
for MUC12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MUC12 gene
- LOC1001315142 MUC162 MUC3A2 MUC172 MUC222
3 SIMAP similar genes for MUC12 using alignment to 5 protein entries: MUC12_HUMAN (see all proteins):MUC17 MUC4 MUC3A
MUC12 for paralogs About GeneDecksing
|
Genomic Variants
for MUC12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MUC12 (100612904 - 100662230 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 22 variations for MUC12
15/21 CNVs (see all 21): 82114 36583 94751 32940 94752 0617 94753 64905 70014 82115 31381 94750 36582 3692 94755
1 Indel: 70015 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MUC12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MUC12 for disorders About GeneDecksing
OMIM gene information: 604609
OMIM disorders: --
11  diseases for MUC12: About MalaCardsotitis media inflammatory bowel disease ulcerative colitis gastric cancer
crohn's disease laryngitis peritonitis colorectal cancer
pneumonia adenocarcinoma malaria
2 Novoseek disease relationships for MUC12 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gastric cancer |
40.4 |
1 |
17387567 (1) |
| tumors |
0 |
2 |
10463611 (2) |
Export disorders for MUC12 gene to outside databases
|
Publications
for MUC12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MUC12 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MUC12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two novel mucin genes down-regulated in colorectal cancer identified by differential display. (PubMed id 10463611)1, 2, 3, 9 Williams S.J....Antalis T.M. (1999)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- MUC12 mRNA expression is an independent marker of pro gnosis in stage II and stage III colorectal cancer. (PubMed id 20162577)1 Matsuyama T....Sugihara K. (2010)
- Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. (PubMed id 18834073)1 Samuels T.L....Johnston N. (2008)
- Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. (PubMed id 17058067)2 Moehle C....Schmitz G. (2006)
- The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins. (PubMed id 15943821)2 Palmai-Pallag T.... Harris A. (2005)
- The increase in mucin exocytosis and the upregulation of MUC genes encoding for membrane-bound mucins induced by the thiol-activated exotoxin listeriolysin O is a host cell defence response that inhibits the cell-entry of Listeria monocytogenes. (PubMed id 15953034)2 Lievin-Le Moal V.... Coconnier-Polter M.-H. (2005)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of MUC1 proteolytic cleavage sites in vivo. (PubMed id 11341784)2 Parry S....Harris A. (2001)
|
External Searches for MUC12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MUC12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MUC12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUC12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MUC12 | Pharmacogenomics, SNPs, Pathways | | Mucin database | http://www.medkem.gu.se/mucinbiology/databases/ |
|
| | |
About This Section
| Patent Information for MUC12 gene:
Search GeneIP for patents involving MUC12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MUC12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUC12 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC12 |
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 |  |  |  | |
| | | | Search Tocris compounds for MUC12 |
| |  |  |  |  | | | | |
 |
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 | | | MUC12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC12 |
|  |  |  | | | | Search ThermoFisher Antibodies for MUC12 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC12 |
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