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Aliases for MTX3 Gene

Aliases for MTX3 Gene

  • Metaxin 3 2 3 5
  • Metaxin-3 3

External Ids for MTX3 Gene

Previous GeneCards Identifiers for MTX3 Gene

  • GC05M079311
  • GC05M074480
  • GC05M079272

Summaries for MTX3 Gene

GeneCards Summary for MTX3 Gene

MTX3 (Metaxin 3) is a Protein Coding gene. An important paralog of this gene is MTX1.

UniProtKB/Swiss-Prot for MTX3 Gene

  • Could function in transport of proteins into the mitochondrion.

Additional gene information for MTX3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTX3 Gene

Genomics for MTX3 Gene

Regulatory Elements for MTX3 Gene

Enhancers for MTX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H080124 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -134.8 -134767 3.1 HDAC1 HDGF PKNOX1 TBL1XR1 BMI1 BATF ZNF143 ZNF207 FOS ATF7 ZFYVE16 MTX3 JMY SERINC5 FAM151B ENSG00000251675 GC05P080097
GH05H079611 1.1 ENCODE 20.5 +378.4 378354 3.5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 PAPD4 MTX3 KRT18P45 LOC644936 RPL39P20 RPS3AP20 CRSP8P SPZ1 GC05M079620
GH05H080179 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -196.6 -196591 17.2 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF766 SP5 SERINC5 PAPD4 ENSG00000251675 MTX3 CTD-2201I18.1 THBS4 DHFR LINC01337 GC05P080147
GH05H080251 1.6 Ensembl ENCODE dbSUPER 12 -263.9 -263924 7.7 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 FOS SP3 PAPD4 RPS3AP20 MTX3 ENSG00000251675 CTD-2201I18.1 THBS4 DHFR SERINC5 GC05P080147
GH05H079511 1.2 ENCODE 14.5 +477.7 477661 3.6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 PAPD4 MTX3 JMY GC05P079511 HOMER1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTX3 on UCSC Golden Path with GeneCards custom track

Promoters for MTX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000183128 265 1201 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 ZNF121 GLIS2

Genomic Locations for MTX3 Gene

Genomic Locations for MTX3 Gene
chr5:79,976,716-79,991,265
(GRCh38/hg38)
Size:
14,550 bases
Orientation:
Minus strand
chr5:79,272,539-79,287,088
(GRCh37/hg19)

Genomic View for MTX3 Gene

Genes around MTX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTX3 Gene

Proteins for MTX3 Gene

  • Protein details for MTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYI7-MTX3_HUMAN
    Recommended name:
    Metaxin-3
    Protein Accession:
    Q5HYI7
    Secondary Accessions:
    • B4DL65
    • E9PB57
    • Q7Z380
    • Q8NB92

    Protein attributes for MTX3 Gene

    Size:
    312 amino acids
    Molecular mass:
    35093 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD97995.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTX3 Gene

Post-translational modifications for MTX3 Gene

  • Ubiquitination at Lys77
  • Modification sites at PhosphoSitePlus

Other Protein References for MTX3 Gene

No data available for DME Specific Peptides for MTX3 Gene

Domains & Families for MTX3 Gene

Gene Families for MTX3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTX3 Gene

Suggested Antigen Peptide Sequences for MTX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HYI7

UniProtKB/Swiss-Prot:

MTX3_HUMAN :
  • Belongs to the metaxin family.
Family:
  • Belongs to the metaxin family.
genes like me logo Genes that share domains with MTX3: view

Function for MTX3 Gene

Molecular function for MTX3 Gene

UniProtKB/Swiss-Prot Function:
Could function in transport of proteins into the mitochondrion.

Phenotypes From GWAS Catalog for MTX3 Gene

Phenotypes for MTX3 Gene

GenomeRNAi human phenotypes for MTX3:
genes like me logo Genes that share phenotypes with MTX3: view

miRNA for MTX3 Gene

miRTarBase miRNAs that target MTX3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTX3 Gene

Localization for MTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTX3 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTX3 gene
Compartment Confidence
mitochondrion 4
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MTX3: view

Pathways & Interactions for MTX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IEA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with MTX3: view

No data available for Pathways by source and SIGNOR curated interactions for MTX3 Gene

Drugs & Compounds for MTX3 Gene

No Compound Related Data Available

Transcripts for MTX3 Gene

Unigene Clusters for MTX3 Gene

Metaxin 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTX3 Gene

No ASD Table

Relevant External Links for MTX3 Gene

GeneLoc Exon Structure for
MTX3
ECgene alternative splicing isoforms for
MTX3

Expression for MTX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTX3 Gene

Protein differential expression in normal tissues from HIPED for MTX3 Gene

This gene is overexpressed in Tlymphocyte (21.9), Monocytes (11.4), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTX3 Gene



NURSA nuclear receptor signaling pathways regulating expression of MTX3 Gene:

MTX3

SOURCE GeneReport for Unigene cluster for MTX3 Gene:

Hs.531418

Evidence on tissue expression from TISSUES for MTX3 Gene

  • Eye(4.1)
  • Skin(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with MTX3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTX3 Gene

Orthologs for MTX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTX3 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia MTX3 33 34
  • 93.9 (n)
cow
(Bos Taurus)
Mammalia MTX3 34 33
  • 92.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mtx3 33 16 34
  • 87.19 (n)
rat
(Rattus norvegicus)
Mammalia Mtx3 33
  • 86.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MTX3 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTX3 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTX3 33 34
  • 78.95 (n)
lizard
(Anolis carolinensis)
Reptilia MTX3 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtx3 33
  • 71.45 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535564 33
  • 63.96 (n)
mtx3 34 34
  • 47 (a)
OneToMany
Dr.29098 33
fruit fly
(Drosophila melanogaster)
Insecta CG9393 34
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mtx-1 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.877 34
  • 24 (a)
OneToMany
Species where no ortholog for MTX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTX3 Gene

ENSEMBL:
Gene Tree for MTX3 (if available)
TreeFam:
Gene Tree for MTX3 (if available)

Paralogs for MTX3 Gene

Paralogs for MTX3 Gene

(1) SIMAP similar genes for MTX3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MTX3 Gene

genes like me logo Genes that share paralogs with MTX3: view

Variants for MTX3 Gene

Sequence variations from dbSNP and Humsavar for MTX3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000069361 -- 79,986,575(+) AAGCA(A/G)CAGGT intron-variant
rs1000540580 -- 79,979,166(+) ACAAG(A/G)GTTTG utr-variant-3-prime
rs1000644949 -- 79,979,957(+) TCTAT(A/G)AATTT utr-variant-3-prime
rs1000920327 -- 79,991,994(+) AGGCT(C/T)TGTGC intron-variant, upstream-variant-2KB
rs1001312955 -- 79,977,931(+) AAATA(C/T)AAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTX3 Gene

Variant ID Type Subtype PubMed ID
nsv823106 CNV loss 20364138
nsv1021113 CNV gain 25217958
esv3605548 CNV loss 21293372
esv2763465 CNV loss 21179565

Variation tolerance for MTX3 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTX3 Gene

Disorders for MTX3 Gene

Relevant External Links for MTX3

Genetic Association Database (GAD)
MTX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTX3

No disorders were found for MTX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTX3 Gene

Publications for MTX3 Gene

  1. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. (PMID: 15087125) Adolph KW (Gene 2004) 2 3 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for MTX3 Gene

Sources for MTX3 Gene

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