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MTX3 Gene

protein-coding   GIFtS: 47
GCID: GC05M079272

Metaxin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metaxin 31 2
metaxin-32
C5

External Ids:    HGNC: 248121   Entrez Gene: 3457782   Ensembl: ENSG000001770347   OMIM: 3028025   UniProtKB: Q5HYI73   

Export aliases for MTX3 gene to outside databases

Previous GC identifers: GC05M079311 GC05M074480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTX3 Gene:
MTX3 (metaxin 3) is a protein-coding gene. Diseases associated with MTX3 include charcot-marie-tooth neuropathy x, and central nervous system lymphoma. An important paralog of this gene is MTX1.

UniProtKB/Swiss-Prot: MTX3_HUMAN, Q5HYI7
Function: Could function in transport of proteins into the mitochondrion (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTX3 gene promoter:
         HOXA9   AP-1   HTF   RelA   CUTL1   GATA-2   FOXO1a   FOXO1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTX3 promoter sequence
   Search Chromatin IP Primers for MTX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.1   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

MTX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTX3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M079272:  view genomic region     (about GC identifiers)

Start:
79,272,539 bp from pter      End:
79,287,088 bp from pter
Size:
14,550 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MTX3_HUMAN, Q5HYI7 (See protein sequence)
Recommended Name: Metaxin-3  
Size: 312 amino acids; 35093 Da
Sequence caution: Sequence=CAD97995.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DL65 E9PB57 Q7Z380 Q8NB92
Alternative splicing: 4 isoforms:  Q5HYI7-1   Q5HYI7-2   Q5HYI7-4   Q5HYI7-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTX3: NX_Q5HYI7

Explore proteomics data for MTX3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77
  • Modification sites at PhosphoSitePlus

  • See MTX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001010891.4  NP_001161213.1  

    ENSEMBL proteins: 
     ENSP00000423600   ENSP00000423302   ENSP00000424798  

    MTX3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MTX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017410 Metaxin
     IPR010987 Glutathione-S-Trfase_C-like
     IPR019564 Sam37/metaxin

    Graphical View of Domain Structure for InterPro Entry Q5HYI7

    ProtoNet protein and cluster: Q5HYI7

    UniProtKB/Swiss-Prot: MTX3_HUMAN, Q5HYI7
    Similarity: Belongs to the metaxin family


    MTX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTX3_HUMAN, Q5HYI7
    Function: Could function in transport of proteins into the mitochondrion (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTX3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTX3
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    miRNA
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    miRTarBase miRNAs that target MTX3:
    hsa-mir-9-5p (MIRT021418), hsa-mir-148b-3p (MIRT019429), hsa-mir-30a-5p (MIRT005190)

    Block miRNA regulation of human, mouse, rat MTX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTX3 (see all 82):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-607 hsa-miR-300 hsa-miR-30d hsa-miR-3921 hsa-miR-10b* hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MTX3

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTX3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTX3_HUMAN, Q5HYI7: Mitochondrion outer membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IEA--

    MTX3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTX3
    Interactions:

        Search GeneGlobe Interaction Network for MTX3

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion IEA--

    MTX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTX3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTX3 gene (2 alternative transcripts): 
    NM_001010891.4  NM_001167741.1  

    Unigene Cluster for MTX3:

    Metaxin 3
    Hs.531418  [show with all ESTs]
    Unigene Representative Sequence: NM_001167741
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512560(uc003kge.4 uc010jah.3 uc010jag.3) ENST00000509852
    ENST00000512528
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTX3 (see all 82):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-607 hsa-miR-300 hsa-miR-30d hsa-miR-3921 hsa-miR-10b* hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTX3
    Predesigned siRNA for gene silencing in human, mouse, rat MTX3
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    OriGene ORF clones in mouse, rat for MTX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MTX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTX3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MTX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MTX3
      QuantiTect SYBR Green Assays in human, mouse, rat MTX3
      QuantiFast Probe-based Assays in human, mouse, rat MTX3

    Additional mRNA sequence: 

    AK296864.1 BC035085.1 BC150295.1 BX537790.1 BX538064.1 BX647596.1 

    6 DOTS entries:

    DT.202598  DT.404170  DT.120848654  DT.100001434  DT.100665832  DT.75115343 

    Selected AceView cDNA sequences (see all 80):

    CD679006 BQ924925 AI743044 BQ945174 AI613195 AA886176 CA445861 AA663255 
    AA723131 BQ773098 AA625606 AA411667 AA443160 AI572723 CA446749 AA926911 
    BX537790 AI648641 AA180315 AW340403 CF457210 AA418807 BM989302 AA233787 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTGTTCT
    MTX3 Expression
    About this image

    MTX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531418
        Custom PCR Arrays for MTX3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTX3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtx31 , 5 metaxin 31, 5 87.19(n)1
    91.32(a)1
      13 (47.78 cM)5
    3827931  NM_001162945.11  NP_001156417.11 
     928447875 
    chicken
    (Gallus gallus)
    Aves MTX31 metaxin 3 78.95(n)
    80.97(a)
      427176  NM_001079483.1  NP_001072951.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTX36
    metaxin 3
    62(a)
    1 ↔ 1
    2(12561266-12577264)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mtx31 metaxin 3 71.45(n)
    74.26(a)
      100493350  XM_002940200.2  XP_002940246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290982 Danio rerio metaxin 3 mRNA, complete cds 79.15(n)    AY194226.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93936
    --
    18(a)
    1 → many
    3R(5387305-5389395)
    worm
    (Caenorhabditis elegans)
    Secernentea mtx-16
    Protein MTX-1 (mtx-1) mRNA, complete cds
    23(a)
    1 → many
    I(14755151-14756426) WBGene00009559


    ENSEMBL Gene Tree for MTX3 (if available)
    TreeFam Gene Tree for MTX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTX3 gene
    MTX12  MTX22  
    1 SIMAP similar gene for MTX3 using alignment to 1 protein entry:     MTX3_HUMAN:
    MTX1

    MTX3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MTX3
    PGOHUM00000243996


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTX3 (see all 354)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25786041,2
    H--79272040(+) AGAGCA/CCAAGT 2 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1383500681,2
    --79272101(+) GCTCAC/TGCCTG 2 -- int10--------
    rs1428502261,2
    C--79272102(+) CTCACA/GCCTGT 2 -- int10--------
    rs561532541,2
    C--79272219(+) AAAAAAAA/-TACCA 2 -- cds11Minor allele frequency- -:0.00NA 2
    rs3721496771,2
    C--79272222(+) AAATA-/CCAAAAA 2 -- int10--------
    rs709820141,2
    C--79272224(+) AAAAA-/ATTTAG 2 -- int12Minor allele frequency- A:0.25NA 4
    rs1878330991,2
    --79272321(+) CAGGTA/GGCGAA 2 -- int10--------
    rs1929261761,2
    --79272323(+) GGTGGC/TGAAGG 2 -- int10--------
    rs1823485591,2
    --79272351(+) CACACC/TATTGC 2 -- int10--------
    rs24047081,2
    C,F,H--79272431(-) CATAGC/TGGGTT 2 -- int115Minor allele frequency- T:0.39NS EA NA WA CSA 776

    HapMap Linkage Disequilibrium report for MTX3 (79272539 - 79287088 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MTX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv823106CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTX3
    DNA2.0 Custom Variant and Variant Library Synthesis for MTX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 302802    OMIM disorders: --

    3 diseases for MTX3:    
    About MalaCards
    charcot-marie-tooth neuropathy x    central nervous system lymphoma    neuropathy

    1 disease from the University of Copenhagen DISEASES database for MTX3:
    Central nervous system lymphoma

    MTX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTX3

    Export disorders for MTX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTX3 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with MTX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. (PubMed id 15087125)1, 3, 9 Adolph K.W. (Gene 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 345778 HGNC: 24812 AceView: MTX3 Ensembl:ENSG00000177034 euGenes: HUgn345778
    ECgene: MTX3 H-InvDB: MTX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTX3 gene:
    Search GeneIP for patents involving MTX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MTX3  
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     Block miRNA regulation of human, mouse, rat MTX3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MTX3
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     Custom PCR Arrays for MTX3 Search Chromatin IP Primers for MTX3
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTX3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTX3
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