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Aliases for MTX3 Gene

Aliases for MTX3 Gene

  • Metaxin 3 2 3 5
  • Metaxin-3 3

External Ids for MTX3 Gene

Previous GeneCards Identifiers for MTX3 Gene

  • GC05M079311
  • GC05M074480
  • GC05M079272

Summaries for MTX3 Gene

GeneCards Summary for MTX3 Gene

MTX3 (Metaxin 3) is a Protein Coding gene. An important paralog of this gene is MTX1.

UniProtKB/Swiss-Prot for MTX3 Gene

  • Could function in transport of proteins into the mitochondrion.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTX3 Gene

Genomics for MTX3 Gene

Regulatory Elements for MTX3 Gene

Enhancers for MTX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G079989 1.1 ENCODE 7 +0.3 300 2.1 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 SP3 MTX3 LINC01455
GH05G079974 0.6 ENCODE 0.4 +16.1 16086 1.0 GATA3 JUND FOSL2 FOS CUX1 PRDM1 TCF7L2 THBS4 MTX3 LINC01455
GH05G079955 0.7 ENCODE 0.3 +34.7 34745 2.0 ZBTB21 ZIC2 HIC1 CTBP1 GATA3 POLR2A ZNF366 FOSL2 FOS ZNF600 THBS4 CTD-2201I18.1 LINC01455 MTX3
GH05G079962 0.6 ENCODE 0.3 +28.2 28194 0.3 ZSCAN21 JUND POLR2A ZBTB21 SMARCA4 CEBPA CEBPG THBS4 LINC01455 MTX3
GH05G079980 0.4 ENCODE 0.4 +10.1 10074 0.8 PKNOX1 THBS4 MTX3 LINC01455
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTX3 on UCSC Golden Path with GeneCards custom track

Promoters for MTX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000183128 265 1201 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 SP3

Genomic Location for MTX3 Gene

79,976,716 bp from pter
79,991,265 bp from pter
14,550 bases
Minus strand

Genomic View for MTX3 Gene

Genes around MTX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTX3 Gene

Proteins for MTX3 Gene

  • Protein details for MTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DL65
    • E9PB57
    • Q7Z380
    • Q8NB92

    Protein attributes for MTX3 Gene

    312 amino acids
    Molecular mass:
    35093 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD97995.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTX3 Gene


neXtProt entry for MTX3 Gene

Post-translational modifications for MTX3 Gene

  • Ubiquitination at posLast=7777
  • Modification sites at PhosphoSitePlus

Other Protein References for MTX3 Gene

No data available for DME Specific Peptides for MTX3 Gene

Domains & Families for MTX3 Gene

Protein Domains for MTX3 Gene

Suggested Antigen Peptide Sequences for MTX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metaxin family.
  • Belongs to the metaxin family.
genes like me logo Genes that share domains with MTX3: view

No data available for Gene Families for MTX3 Gene

Function for MTX3 Gene

Molecular function for MTX3 Gene

UniProtKB/Swiss-Prot Function:
Could function in transport of proteins into the mitochondrion.

Phenotypes for MTX3 Gene

GenomeRNAi human phenotypes for MTX3:
genes like me logo Genes that share phenotypes with MTX3: view

Animal Model Products

miRNA for MTX3 Gene

miRTarBase miRNAs that target MTX3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTX3 Gene

Localization for MTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTX3 Gene

Mitochondrion outer membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTX3 gene
Compartment Confidence
mitochondrion 4
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MTX3: view

Pathways & Interactions for MTX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IEA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with MTX3: view

No data available for Pathways by source and SIGNOR curated interactions for MTX3 Gene

Drugs & Compounds for MTX3 Gene

No Compound Related Data Available

Transcripts for MTX3 Gene

Unigene Clusters for MTX3 Gene

Metaxin 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTX3 Gene

No ASD Table

Relevant External Links for MTX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTX3 Gene

Protein differential expression in normal tissues from HIPED for MTX3 Gene

This gene is overexpressed in Tlymphocyte (21.9), Monocytes (11.4), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTX3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTX3 Gene:


SOURCE GeneReport for Unigene cluster for MTX3 Gene:


Evidence on tissue expression from TISSUES for MTX3 Gene

  • Eye(4.1)
  • Skin(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with MTX3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTX3 Gene

Orthologs for MTX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTX3 34 35
  • 99.46 (n)
(Canis familiaris)
Mammalia MTX3 34 35
  • 93.9 (n)
(Bos Taurus)
Mammalia MTX3 34 35
  • 92.82 (n)
(Mus musculus)
Mammalia Mtx3 34 16 35
  • 87.19 (n)
(Rattus norvegicus)
Mammalia Mtx3 34
  • 86.72 (n)
(Ornithorhynchus anatinus)
Mammalia MTX3 35
  • 70 (a)
(Monodelphis domestica)
Mammalia MTX3 35
  • 68 (a)
(Gallus gallus)
Aves MTX3 34 35
  • 78.95 (n)
(Anolis carolinensis)
Reptilia MTX3 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtx3 34
  • 71.45 (n)
(Danio rerio)
Actinopterygii LOC100535564 34
  • 63.96 (n)
mtx3 35 35
  • 47 (a)
Dr.29098 34
fruit fly
(Drosophila melanogaster)
Insecta CG9393 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea mtx-1 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.877 35
  • 24 (a)
Species where no ortholog for MTX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTX3 Gene

Gene Tree for MTX3 (if available)
Gene Tree for MTX3 (if available)

Paralogs for MTX3 Gene

Paralogs for MTX3 Gene

(1) SIMAP similar genes for MTX3 Gene using alignment to 1 proteins: Pseudogenes for MTX3 Gene

genes like me logo Genes that share paralogs with MTX3: view

Variants for MTX3 Gene

Sequence variations from dbSNP and Humsavar for MTX3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000069361 -- 79,986,575(+) AAGCA(A/G)CAGGT intron-variant
rs1000540580 -- 79,979,166(+) ACAAG(A/G)GTTTG utr-variant-3-prime
rs1000644949 -- 79,979,957(+) TCTAT(A/G)AATTT utr-variant-3-prime
rs1000920327 -- 79,991,994(+) AGGCT(C/T)TGTGC intron-variant, upstream-variant-2KB
rs1001312955 -- 79,977,931(+) AAATA(C/T)AAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTX3 Gene

Variant ID Type Subtype PubMed ID
esv2763465 CNV loss 21179565
esv3605548 CNV loss 21293372
nsv1021113 CNV gain 25217958
nsv823106 CNV loss 20364138

Variation tolerance for MTX3 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTX3 Gene

Disorders for MTX3 Gene

Relevant External Links for MTX3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MTX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTX3 Gene

Publications for MTX3 Gene

  1. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. (PMID: 15087125) Adolph K.W. (Gene 2004) 2 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for MTX3 Gene

Sources for MTX3 Gene

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