Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTX3 Gene

Aliases for MTX3 Gene

  • Metaxin 3 2 3 5

External Ids for MTX3 Gene

Previous GeneCards Identifiers for MTX3 Gene

  • GC05M079311
  • GC05M074480
  • GC05M079272

Summaries for MTX3 Gene

GeneCards Summary for MTX3 Gene

MTX3 (Metaxin 3) is a Protein Coding gene. An important paralog of this gene is MTX2.

UniProtKB/Swiss-Prot for MTX3 Gene

  • Could function in transport of proteins into the mitochondrion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTX3 Gene

Genomics for MTX3 Gene

Regulatory Elements for MTX3 Gene

Promoters for MTX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTX3 Gene

Chromosome:
5
Start:
79,976,716 bp from pter
End:
79,991,265 bp from pter
Size:
14,550 bases
Orientation:
Minus strand

Genomic View for MTX3 Gene

Genes around MTX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTX3 Gene

Proteins for MTX3 Gene

  • Protein details for MTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYI7-MTX3_HUMAN
    Recommended name:
    Metaxin-3
    Protein Accession:
    Q5HYI7
    Secondary Accessions:
    • B4DL65
    • E9PB57
    • Q7Z380
    • Q8NB92

    Protein attributes for MTX3 Gene

    Size:
    312 amino acids
    Molecular mass:
    35093 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD97995.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTX3 Gene

Proteomics data for MTX3 Gene at MOPED

Post-translational modifications for MTX3 Gene

  • Ubiquitination at Lys 77
  • Modification sites at PhosphoSitePlus

Other Protein References for MTX3 Gene

No data available for DME Specific Peptides for MTX3 Gene

Domains & Families for MTX3 Gene

Protein Domains for MTX3 Gene

Suggested Antigen Peptide Sequences for MTX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HYI7

UniProtKB/Swiss-Prot:

MTX3_HUMAN :
  • Belongs to the metaxin family.
Family:
  • Belongs to the metaxin family.
genes like me logo Genes that share domains with MTX3: view

No data available for Gene Families for MTX3 Gene

Function for MTX3 Gene

Molecular function for MTX3 Gene

UniProtKB/Swiss-Prot Function:
Could function in transport of proteins into the mitochondrion.

Phenotypes for MTX3 Gene

GenomeRNAi human phenotypes for MTX3:
genes like me logo Genes that share phenotypes with MTX3: view

Animal Model Products

miRNA for MTX3 Gene

miRTarBase miRNAs that target MTX3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTX3 Gene

Localization for MTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTX3 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTX3 Gene COMPARTMENTS Subcellular localization image for MTX3 gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MTX3 Gene

Pathways & Interactions for MTX3 Gene

SuperPathways for MTX3 Gene

No Data Available

Interacting Proteins for MTX3 Gene

Gene Ontology (GO) - Biological Process for MTX3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTX3 Gene

Drugs & Compounds for MTX3 Gene

No Compound Related Data Available

Transcripts for MTX3 Gene

Unigene Clusters for MTX3 Gene

Metaxin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTX3 Gene

No ASD Table

Relevant External Links for MTX3 Gene

GeneLoc Exon Structure for
MTX3
ECgene alternative splicing isoforms for
MTX3

Expression for MTX3 Gene

mRNA expression in normal human tissues for MTX3 Gene

Protein differential expression in normal tissues from HIPED for MTX3 Gene

This gene is overexpressed in Tlymphocyte (21.9), Monocytes (11.4), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTX3 Gene



SOURCE GeneReport for Unigene cluster for MTX3 Gene Hs.531418

genes like me logo Genes that share expression patterns with MTX3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MTX3 Gene

Orthologs for MTX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTX3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTX3 35
  • 92.82 (n)
  • 94.72 (a)
MTX3 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTX3 35
  • 93.9 (n)
  • 95.93 (a)
MTX3 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtx3 35
  • 87.19 (n)
  • 91.32 (a)
Mtx3 16
Mtx3 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTX3 35
  • 99.46 (n)
  • 100 (a)
MTX3 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtx3 35
  • 86.72 (n)
  • 89.84 (a)
oppossum
(Monodelphis domestica)
Mammalia MTX3 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTX3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTX3 35
  • 78.95 (n)
  • 80.97 (a)
MTX3 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTX3 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtx3 35
  • 71.45 (n)
  • 74.26 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.29098 35
LOC100535564 35
  • 63.96 (n)
  • 60.57 (a)
mtx3 36
  • 47 (a)
OneToMany
mtx3 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9393 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mtx-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.877 36
  • 24 (a)
OneToMany
Species with no ortholog for MTX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTX3 Gene

ENSEMBL:
Gene Tree for MTX3 (if available)
TreeFam:
Gene Tree for MTX3 (if available)

Paralogs for MTX3 Gene

Paralogs for MTX3 Gene

(1) SIMAP similar genes for MTX3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MTX3 Gene

genes like me logo Genes that share paralogs with MTX3: view

Variants for MTX3 Gene

Sequence variations from dbSNP and Humsavar for MTX3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs9293796 - 79,986,975(+) TAACT(C/G)CTCAG reference, missense
rs1047767 -- 79,977,500(-) GGTTT(A/T)GAGTT utr-variant-3-prime
rs1055188 -- 79,983,346(-) TGAAT(A/G)TGCAC utr-variant-3-prime
rs1055189 -- 79,983,308(-) AATTT(A/T)TTAAC utr-variant-3-prime
rs1222026 -- 79,984,408(-) TCTAC(A/C/G)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTX3 Gene

Variant ID Type Subtype PubMed ID
nsv823106 CNV Loss 20364138

Variation tolerance for MTX3 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTX3 Gene

HapMap Linkage Disequilibrium report
MTX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTX3 Gene

Disorders for MTX3 Gene

Relevant External Links for MTX3

Genetic Association Database (GAD)
MTX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTX3

No disorders were found for MTX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTX3 Gene

Publications for MTX3 Gene

  1. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. (PMID: 15087125) Adolph K.W. (Gene 2004) 2 3 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MTX3 Gene

Sources for MTX3 Gene

Back to Top

Content