MTX3 Gene
protein-coding GIFtS: 44
GCID: GC05M079272
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metaxin 3
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Aliases
for MTX3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Metaxin 31 2 | | Metaxin-31 | | C5 |
Export aliases for MTX3 gene to outside databasesPrevious GC identifers: GC05M079311 GC05M074480 |
Summaries
for MTX3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MTX3_HUMAN, Q5HYI7Function: Could function in transport of proteins into the mitochondrion (By similarity)
|
Genomic Views
for MTX3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTX3 gene promoter:
HOXA9 AP-1 HTF RelA CUTL1 GATA-2 FOXO1a FOXO1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTX3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTX3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q14.1 Ensembl cytogenetic band: 5q14.1 HGNC cytogenetic band: 5q14.1MTX3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M079272: view genomic region
(about GC identifiers)
Start:
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79,272,539 bp from pter |
End:
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79,287,088 bp from pter |
Size:
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14,550 bases |
Orientation:
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minus strand |
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Proteins
for MTX3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTX3_HUMAN, Q5HYI7 (See
protein sequence)Recommended Name: Metaxin-3 Size: 312 amino acids; 35093 Da
Subcellular location: Mitochondrion outer membrane (By similarity)
Secondary accessions: B4DL65 Q8NB92Alternative splicing: 3 isoforms: Q5HYI7-1 Q5HYI7-2 Q5HYI7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MTX3: NX_Q5HYI7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5HYI7
MTX3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001010891.4 NP_001161213.1
ENSEMBL proteins: ENSP00000423600 ENSP00000423302 ENSP00000424798
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005741 | mitochondrial outer membrane |
IEA | -- |
MTX3 for ontologies About GeneDecksing
MTX3 Antibody Products:
Assay Products for MTX3: |
Protein
Domains /
Families
for MTX3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTX3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5HYI7ProtoNet protein and cluster: Q5HYI7 UniProtKB/Swiss-Prot: MTX3_HUMAN, Q5HYI7Similarity: Belongs to the metaxin family |
Function
for MTX3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MTX3_HUMAN, Q5HYI7Function: Could function in transport of proteins into the mitochondrion (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTX3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTX3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for MTX3 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTX3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTX3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX3 |
|
Pathways & Interactions
for MTX3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTX3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006626 | protein targeting to mitochondrion |
IEA | -- |
MTX3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTX3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTX3
Search CenterWatch for drugs/clinical trials and news about MTX3
|
Transcripts
for MTX3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTX3 gene (2 alternative transcripts): NM_001010891.4 NM_001167741.1 Unigene Cluster for MTX3: Metaxin 3 Hs.531418 [show with all ESTs]Unigene Representative Sequence: NM_0011677413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000512560(uc003kge.4 uc010jah.3 uc010jag.3) ENST00000509852
ENST00000512528
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTX3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTX3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MTX3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTX3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTX3 |
Additional cDNA sequence: AK296864.1 BC035085.1 BC150295.1 BX537790.1 BX538064.1 BX647596.1 6 DOTS entries: DT.202598 DT.404170 DT.120848654 DT.100001434 DT.100665832 DT.75115343 24/80 AceView cDNA sequences (see all 80): BQ924925 AI648641 AA723131 AA443160 AI572723 AA625606 AA886176 AI613195 BQ945174 AA926911 AA411667 AI743044 CD679006 CA445861 BQ773098 CA446749 AA663255 BX537790 AA233787 AA418807 AW340403 CF457210 BE855822 BU193968
GeneLoc Exon Structure
|
Expression
for MTX3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACTGTTCT
About this image
See MTX3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTX3
SOURCE GeneReport for Unigene cluster: Hs.531418
SABiosciences Custom PCR Arrays for MTX3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTX3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MTX3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTX3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTX3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX3 |
Orthologs
for MTX3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MTX3 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for MTX3 (if available)
TreeFam Gene Tree for MTX3 (if available) |
Paralogs
for MTX3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTX3 gene
- MTX12 MTX22
1 SIMAP similar gene for MTX3 using alignment to 3 protein entries: MTX3_HUMAN (see all proteins):MTX1
MTX3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MTX3
PGOHUM00000243996
|
Genomic Variants
for MTX3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTX3 (79272539 - 79287088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MTX3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTX3 |
|
Disorders
/ Diseases
for MTX3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTX3 for disorders About GeneDecksing
OMIM gene information: 302802
OMIM disorders: --
5  diseases for MTX3: About MalaCardscharcot-marie-tooth neuropathy, x-linked recessive, 3 charcot-marie-tooth neuropathy charcot-marie-tooth neuropathy x cns lymphoma
neuropathy
1 disease from the University of Copenhagen DISEASES database for MTX3:Central nervous system lymphoma Export disorders for MTX3 gene to outside databases
|
Publications
for MTX3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTX3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MTX3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. (PubMed id 15087125)1, 3, 9 Adolph K.W. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MTX3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTX3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTX3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTX3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTX3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MTX3 gene:
Search GeneIP for patents involving MTX3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTX3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTX3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTX3 | | | OriGene Protein Over-expression Lysate for MTX3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MTX3 | | OriGene 3'-UTR Clone for MTX3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTX3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTX3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MTX3 | | OriGene Custom Protein Services for MTX3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTX3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTX3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTX3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTX3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTX3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTX3 |
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 |  |  |  | |
| | | | Search Tocris compounds for MTX3 |
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 | | | MTX3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX3 |
|  |  |  | | | | Search ThermoFisher Antibodies for MTX3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTX3 |
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