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Aliases for MTX2 Gene

Aliases for MTX2 Gene

  • Metaxin 2 2 3
  • Mitochondrial Outer Membrane Import Complex Protein 2 3 4
  • Metaxin-2 3

External Ids for MTX2 Gene

Previous GeneCards Identifiers for MTX2 Gene

  • GC02P175196
  • GC02P175805
  • GC02P177098
  • GC02P177336
  • GC02P176959
  • GC02P176844
  • GC02P177134
  • GC02P169011

Summaries for MTX2 Gene

Entrez Gene Summary for MTX2 Gene

  • The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jun 2009]

GeneCards Summary for MTX2 Gene

MTX2 (Metaxin 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. An important paralog of this gene is MTX3.

UniProtKB/Swiss-Prot for MTX2 Gene

  • Involved in transport of proteins into the mitochondrion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTX2 Gene

Genomics for MTX2 Gene

Regulatory Elements for MTX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTX2 Gene

176,269,395 bp from pter
176,338,025 bp from pter
68,631 bases
Plus strand

Genomic View for MTX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTX2 Gene

Proteins for MTX2 Gene

  • Protein details for MTX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8JZZ4
    • Q53S50
    • Q53SQ2
    • Q5M7Z6
    • Q8IZ68

    Protein attributes for MTX2 Gene

    263 amino acids
    Molecular mass:
    29763 Da
    Quaternary structure:
    • Interacts with MTX1/metaxin-1. Associates with the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3.

    Alternative splice isoforms for MTX2 Gene


neXtProt entry for MTX2 Gene

Proteomics data for MTX2 Gene at MOPED

Post-translational modifications for MTX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTX2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MTX2 Gene

Domains for MTX2 Gene

Protein Domains for MTX2 Gene

Suggested Antigen Peptide Sequences for MTX2 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75431
  • Belongs to the metaxin family.
genes like me logo Genes that share domains with MTX2: view

No data available for Gene Families for MTX2 Gene

Function for MTX2 Gene

Molecular function for MTX2 Gene

GENATLAS Biochemistry:
metaxin 2,metaxin 1 binding protein,ubiquitously expressed,also homolog to C elegans Cel ZC97.1,located on the cytosolic face of the outer mitochondrial membrane,putatively involved in protein import into mitochondria
UniProtKB/Swiss-Prot Function:
Involved in transport of proteins into the mitochondrion.

Gene Ontology (GO) - Molecular Function for MTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MTX2: view

Phenotypes for MTX2 Gene

genes like me logo Genes that share phenotypes with MTX2: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTX2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MTX2 Gene

Localization for MTX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTX2 Gene

Mitochondrion outer membrane.

Subcellular locations from

Jensen Localization Image for MTX2 Gene COMPARTMENTS Subcellular localization image for MTX2 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with MTX2: view

Pathways for MTX2 Gene

genes like me logo Genes that share pathways with MTX2: view

Pathways by source for MTX2 Gene

2 Reactome pathways for MTX2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006839 mitochondrial transport TAS 10381257
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MTX2: view

Transcripts for MTX2 Gene

Unigene Clusters for MTX2 Gene

Metaxin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTX2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTX2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -

Relevant External Links for MTX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTX2 Gene

mRNA expression in normal human tissues for MTX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MTX2 Gene

This gene is overexpressed in Heart (12.2) and Brain (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTX2 Gene

SOURCE GeneReport for Unigene cluster for MTX2 Gene Hs.470728

genes like me logo Genes that share expressions with MTX2: view

Expression partners for MTX2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTX2 Gene

Orthologs for MTX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MTX2 35
  • 94.1 (n)
  • 97.31 (a)
MTX2 36
  • 94 (a)
(Canis familiaris)
Mammalia MTX2 35
  • 94.42 (n)
  • 98.1 (a)
MTX2 36
  • 97 (a)
(Mus musculus)
Mammalia Mtx2 35
  • 92.14 (n)
  • 96.96 (a)
Mtx2 16
Mtx2 36
  • 97 (a)
(Pan troglodytes)
Mammalia MTX2 35
  • 96.96 (n)
  • 96.2 (a)
MTX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mtx2 35
  • 90.75 (n)
  • 93.92 (a)
(Monodelphis domestica)
Mammalia MTX2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia MTX2 36
  • 85 (a)
(Gallus gallus)
Aves MTX2 35
  • 80.05 (n)
  • 88.42 (a)
MTX2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia MTX2 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtx2 35
  • 78.08 (n)
  • 84.23 (a)
Str.15350 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13610 35
(Danio rerio)
Actinopterygii Dr.23871 35
mtx2 35
  • 70.14 (n)
  • 81.47 (a)
mtx2 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5662 37
  • 36 (a)
CG8004 37
  • 44 (a)
CG8004 35
  • 52.6 (n)
  • 45.08 (a)
CG5662 36
  • 32 (a)
CG8004 36
  • 41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008150 35
  • 48.13 (n)
  • 43.2 (a)
(Caenorhabditis elegans)
Secernentea mtx-2 35
  • 50.13 (n)
  • 38.8 (a)
mtx-2 36
  • 36 (a)
Species with no ortholog for MTX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTX2 Gene

Gene Tree for MTX2 (if available)
Gene Tree for MTX2 (if available)

Paralogs for MTX2 Gene

Paralogs for MTX2 Gene

Selected SIMAP similar genes for MTX2 Gene using alignment to 6 proteins: Pseudogenes for MTX2 Gene

genes like me logo Genes that share paralogs with MTX2: view

Variants for MTX2 Gene

Sequence variations from dbSNP and Humsavar for MTX2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs818363 -- 176,337,342(+) TGGCC(C/T)ATATT intron-variant
rs818364 -- 176,337,387(+) AGGTT(A/G/T)GTTGA intron-variant
rs818365 -- 176,338,248(+) AAAAG(G/T)TTGAG downstream-variant-500B
rs999375 -- 176,283,993(-) ATTTT(C/T)AAAAT intron-variant
rs1403992 -- 176,300,236(-) TAACA(A/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTX2 Gene

Variant ID Type Subtype PubMed ID
nsv523803 CNV Gain 19592680
esv2676194 CNV Deletion 23128226
nsv459952 CNV Loss 19166990

Relevant External Links for MTX2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTX2 Gene

Disorders for MTX2 Gene

Relevant External Links for MTX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MTX2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MTX2 Gene

Publications for MTX2 Gene

  1. Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane. (PMID: 10381257) Armstrong L.C. … Bornstein P. (J. Cell. Biochem. 1999) 2 3 4
  2. Conserved roles of Sam50 and metaxins in VDAC biogenesis. (PMID: 17510655) Kozjak-Pavlovic V. … Rudel T. (EMBO Rep. 2007) 3 23
  3. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil- helix domain-containing protein 3 and 6 and DnaJC11. (PMID: 17624330) Xie J. … Capaldi R.A. (FEBS Lett. 2007) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MTX2 Gene

Sources for MTX2 Gene

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