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MTX2 Gene

protein-coding   GIFtS: 58
GCID: GC02P177134

Metaxin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metaxin 21 2
Mitochondrial Outer Membrane Import Complex Protein 22 3
metaxin-22

External Ids:    HGNC: 75061   Entrez Gene: 106512   Ensembl: ENSG000001286547   OMIM: 6085555   UniProtKB: O754313   

Export aliases for MTX2 gene to outside databases

Previous GC identifers: GC02P175196 GC02P175805 GC02P177098 GC02P177336 GC02P176959 GC02P176844 GC02P169011


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTX2 Gene:
The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to
interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the
encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that
it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple
transcript variants. A related pseudogene has been identified on chromosome 7. (provided by RefSeq, Jun 2009)

GeneCards Summary for MTX2 Gene:
MTX2 (metaxin 2) is a protein-coding gene. Diseases associated with MTX2 include tonsillitis, and prostatitis. An important paralog of this gene is MTX1.

UniProtKB/Swiss-Prot: MTX2_HUMAN, O75431
Function: Involved in transport of proteins into the mitochondrion




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTX2 gene promoter:
         Pax-5   AML1a   FOXF2   Nkx2-2   GATA-1   Pax-3   POU2F1   POU2F1a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTX2 promoter sequence
   Search Chromatin IP Primers for MTX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

MTX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTX2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P177134:  view genomic region     (about GC identifiers)

Start:
177,134,123 bp from pter      End:
177,202,753 bp from pter
Size:
68,631 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MTX2_HUMAN, O75431 (See protein sequence)
Recommended Name: Metaxin-2  
Size: 263 amino acids; 29763 Da
Subunit: Interacts with MTX1/metaxin-1. Associates with the MINOS/MitOS complex, that includes IMMT, HSPA9 and
CHCHD3
Secondary accessions: A8JZZ4 Q53S50 Q53SQ2 Q5M7Z6

Explore the universe of human proteins at neXtProt for MTX2: NX_O75431

Explore proteomics data for MTX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006545.1  
    ENSEMBL proteins: 
     ENSP00000403545   ENSP00000249442   ENSP00000402204   ENSP00000414176   ENSP00000398757  
     ENSP00000376314  
    Reactome Protein details: O75431

    MTX2 Human Recombinant Protein Products:

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    MTX2 Assay Products:

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    Cloud-Clone Corp. CLIAs for MTX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010987 Glutathione-S-Trfase_C-like
     IPR019564 Sam37/metaxin

    Graphical View of Domain Structure for InterPro Entry O75431

    ProtoNet protein and cluster: O75431

    UniProtKB/Swiss-Prot: MTX2_HUMAN, O75431
    Similarity: Belongs to the metaxin family


    MTX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTX2_HUMAN, O75431
    Function: Involved in transport of proteins into the mitochondrion

         Genatlas biochemistry entry for MTX2:
    metaxin 2,metaxin 1 binding protein,ubiquitously expressed,also homolog to C elegans Cel ZC97.1,located on the
    cytosolic face of the outer mitochondrial membrane,putatively involved in protein import into mitochondria

    Phenotypes:
         2 GenomeRNAi human phenotypes for MTX2:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTX2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTX2
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    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MTX2:
    hsa-miR-26a hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidMTX2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MTX2
    Predesigned siRNA for gene silencing in human, mouse, rat MTX2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTX2_HUMAN, O75431: Mitochondrion outer membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome2
    cytoskeleton1
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane IEA--

    MTX2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTX2 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MTX2
        Mitochondrial protein import



    MTX2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MTX2: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MTX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTX2 (O754312, 3 ENSP000002494424) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTX1Q135052, 3, ENSP000003573604MINT-5007196 MINT-4791404 I2D: score=6 STRING: ENSP00000357360
    SAMM50Q9Y5122, ENSP000003454454MINT-5007196 MINT-4791404 STRING: ENSP00000345445
    CHCHD3Q9NX632, ENSP000002625704MINT-5007196 STRING: ENSP00000262570
    MINOS1Q5TGZ03, ENSP000003255624I2D: score=1 STRING: ENSP00000325562
    MEIS2O147703, ENSP000003262964I2D: score=1 STRING: ENSP00000326296
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0006839mitochondrial transport TAS10381257
    GO:0044267cellular protein metabolic process TAS--

    MTX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTX2 gene (2 alternative transcripts): 
    NM_006554.4  NM_001006635.1  

    Unigene Cluster for MTX2:

    Metaxin 2
    Hs.470728  [show with all ESTs]
    Unigene Representative Sequence: NR_027850
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420864(uc002ukw.3 uc002ukx.3) ENST00000249442 ENST00000423461
    ENST00000443241 ENST00000452865 ENST00000392529
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MTX2:
    hsa-miR-26a hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidMTX2 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for MTX2
    OriGene qSTAR qPCR primer pairs in human, mouse for MTX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTX2
      QuantiTect SYBR Green Assays in human, mouse, rat MTX2
      QuantiFast Probe-based Assays in human, mouse, rat MTX2

    Additional mRNA sequence: 

    AF053551.1 AK001287.1 AK289359.1 AK303564.1 AK315918.1 BC017271.2 BC067831.1 BC088359.1 
    NR_027850.1 

    10 DOTS entries:

    DT.452694  DT.91744726  DT.100786240  DT.100024686  DT.100786242  DT.120987881  DT.91744725  DT.95256680 
    DT.101962352  DT.91673212 

    Selected AceView cDNA sequences (see all 160):

    BX328374 AI351477 CB243220 BU508259 BC017271 BQ417485 BQ288036 CR622668 
    AI990767 BU153855 BU192147 AA233279 BU193246 AI991560 N66514 BM970770 
    BU165147 BI835523 BP369188 BX279933 BM836178 AF053551 N98666 AA256376 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MTX2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:              -                                                         


    ECgene alternative splicing isoforms for MTX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTAAAAA
    MTX2 Expression
    About this image


    MTX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    MTX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.470728
        Pathway & Disease-focused RT2 Profiler PCR Array including MTX2: 
              Mitochondria in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTX2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtx21 , 5 metaxin 21, 5 92.14(n)1
    96.96(a)1
      2 (44.13 cM)5
    533751  NM_016804.41  NP_058084.31 
     748258035 
    chicken
    (Gallus gallus)
    Aves MTX21 metaxin 2 80.05(n)
    88.42(a)
      424138  XM_421989.3  XP_421989.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTX26
    metaxin 2
    82(a)
    1 ↔ 1
    GL343356.1(260502-315109)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136102 Xenopus laevis transcribed sequence with moderate similarity more 79.62(n)    CA793260.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.238712 Transcribed sequence with moderate similarity to protein more 73.81(n)    CF550207.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80041 , 3 protein-mitochondrial targeting3
    CG80041
    44(a)
    (best of 2)3
    52.6(n)1
    45.08(a)1
      76D53
    401781  NM_140904.21  NP_649161.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mtx-21 mtx-2 50.13(n)
    38.8(a)
      176087  NM_066288.4  NP_498689.2 


    ENSEMBL Gene Tree for MTX2 (if available)
    TreeFam Gene Tree for MTX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTX2 gene
    MTX12  MTX32  
    5 SIMAP similar genes for MTX2 using alignment to 6 protein entries:     MTX2_HUMAN (see all proteins):
    C19orf47    NDUFS7    TGFBR3    ZNF738    ZNF83

    MTX2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MTX2
    PGOHUM00000233551


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTX2 (see all 1275)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920438521,2
    --177132316(+) TAAGAC/TGCTGC 2 -- us2k10--------
    rs1141412121,2
    F--177132434(+) CTGGGC/AACAGT 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1858005831,2
    C--177132446(+) GCTCAC/TGCCTG 2 -- us2k10--------
    rs1903266491,2
    --177132569(+) GGGCAC/TGGTGG 2 -- us2k10--------
    rs1425951941,2
    --177132571(+) GCATGA/GTGGCA 2 -- us2k10--------
    rs1505558341,2
    C--177132577(+) TGGCAC/GGCACC 2 -- us2k10--------
    rs101707691,2
    C--177132655(+) TGGGCT/CGAGAT 2 -- us2k12Minor allele frequency- C:0.00NA 4
    rs1479209321,2
    --177132723(+) AAAAAA/GAAAAG 2 -- us2k10--------
    rs129995891,2
    C--177132727(+) aaaaaA/Ggaaaa 2 -- us2k1 tfbs3 trp30--------
    rs1496824451,2
    --177132921(+) ATTGCC/TGGCAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTX2 (177134123 - 177202753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MTX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676194CNV Deletion23128226
    nsv459952CNV Loss19166990
    nsv523803CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTX2
    DNA2.0 Custom Variant and Variant Library Synthesis for MTX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608555    OMIM disorders: --

    7 diseases for MTX2:    
    About MalaCards
    tonsillitis    prostatitis    prostate cancer    malaria
    cerebritis    thyroiditis    endotheliitis


    MTX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTX2
    Human Genome Epidemiology (HuGE) Navigator: MTX2 (2 documents)

    Export disorders for MTX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTX2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MTX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane. (PubMed id 10381257)1, 2, 3 Armstrong L.C.... Bornstein P. (J. Cell. Biochem. 1999)
    2. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. (PubMed id 22114354)1, 2 Alkhaja A.K.... Deckers M. (Mol. Biol. Cell 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil- helix domain-containing protein 3 and 6 and DnaJC11. (PubMed id 17624330)1, 3 Xie J.... Capaldi R.A. (FEBS Lett. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Conserved roles of Sam50 and metaxins in VDAC biogenesis. (PubMed id 17510655)1, 9 Kozjak-Pavlovic V....Rudel T. (EMBO Rep. 2007)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10651 HGNC: 7506 AceView: MTX2 Ensembl:ENSG00000128654 euGenes: HUgn10651
    ECgene: MTX2 H-InvDB: MTX2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTX2 gene:
    Search GeneIP for patents involving MTX2

    GeneCards and IP:
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