MTX2 Gene
protein-coding GIFtS: 56
GCID: GC02P177134
|
|
metaxin 2
| |
Aliases
for MTX2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Metaxin 21 2 | | Mitochondrial Outer Membrane Import Complex Protein 22 3 | | Metaxin-21 |
| External Ids: | HGNC: 75061 | Entrez Gene: 106512 | Ensembl: ENSG000001286547 | OMIM: 6085555 | UniProtKB: O754313 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408049 | |
Export aliases for MTX2 gene to outside databasesPrevious GC identifers: GC02P175196 GC02P175805 GC02P177098 GC02P177336 GC02P176959 GC02P176844 GC02P169011
Summaries
for MTX2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MTX2:
The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown tointeract with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encodedprotein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it isinvolved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcriptvariants. A related pseudogene has been identified on chromosome 7. (provided by RefSeq, Jun 2009)
UniProtKB/Swiss-Prot: MTX2_HUMAN, O75431Function: Involved in transport of proteins into the mitochondrion
|
Genomic Views
for MTX2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTX2 gene promoter:
Pax-5 AML1a FOXF2 Nkx2-2 GATA-1 Pax-3 POU2F1 POU2F1a RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTX2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTX2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1MTX2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P177134: view genomic region
(about GC identifiers)
Start:
|
177,134,123 bp from pter |
End:
|
177,202,753 bp from pter |
Size:
|
68,631 bases |
Orientation:
|
plus strand |
|
Proteins
for MTX2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTX2_HUMAN, O75431 (See
protein sequence)Recommended Name: Metaxin-2 Size: 263 amino acids; 29763 Da
Subunit: Interacts with MTX1/metaxin-1. Associates with the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3
Subcellular location: Mitochondrion outer membrane
Secondary accessions: A8JZZ4 Q53S50 Q53SQ2 Q5M7Z6Explore the universe of human proteins at neXtProt for MTX2: NX_O75431
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75431
MTX2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006545.1
ENSEMBL proteins: ENSP00000403545 ENSP00000249442 ENSP00000402204 ENSP00000414176 ENSP00000398757 ENSP00000376314 Reactome Protein details: O75431
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005741 | mitochondrial outer membrane |
IEA | -- |
MTX2 for ontologies About GeneDecksing
MTX2 Antibody Products:
Assay Products for MTX2: |
Protein
Domains /
Families
for MTX2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTX2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75431ProtoNet protein and cluster: O75431 UniProtKB/Swiss-Prot: MTX2_HUMAN, O75431Similarity: Belongs to the metaxin family |
Function
for MTX2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MTX2_HUMAN, O75431Function: Involved in transport of proteins into the mitochondrion Genatlas biochemistry entry for MTX2:metaxin 2,metaxin 1 binding protein,ubiquitously expressed,also homolog to C elegans Cel ZC97.1,located on thecytosolic face of the outer mitochondrial membrane,putatively involved in protein import into mitochondria
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTX2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX2 |
2 GenomeRNAi human phenotypes for MTX2:
|
Pathways & Interactions
for MTX2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for MTX2
MTX2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTX2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/22 Interacting proteins for MTX2 (O754312, 3 ENSP000002494424) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MTX2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTX2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTX2
Search CenterWatch for drugs/clinical trials and news about MTX2
|
Transcripts
for MTX2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTX2 gene (2 alternative transcripts): NM_006554.4 NM_001006635.1 Unigene Cluster for MTX2: Metaxin 2 Hs.470728 [show with all ESTs]Unigene Representative Sequence: NR_0278506 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000420864(uc002ukw.3 uc002ukx.3) ENST00000249442 ENST00000423461
ENST00000443241 ENST00000452865 ENST00000392529
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTX2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTX2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MTX2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTX2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTX2 |
Additional cDNA sequence: AF053551.1 AK001287.1 AK289359.1 AK303564.1 AK315918.1 BC017271.2 BC067831.1 BC088359.1 NR_027850.1 10 DOTS entries: DT.452694 DT.91744726 DT.100786240 DT.100024686 DT.100786242 DT.120987881 DT.91744725 DT.95256680 DT.101962352 DT.91673212 24/160 AceView cDNA sequences (see all 160): BU508259 CR622668 BQ288036 BQ417485 BC017271 BU192147 AI990767 BU153855 CB243220 BX328374 AI351477 BI835523 BP369188 BX279933 BM836178 AF053551 NM_006554 N98666 AA256376 CR617418 AA256436 BQ890398 BU677822 AA515286
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MTX2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MTX2
|
Expression
for MTX2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTAAAAA
About this image
See MTX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTX2
SOURCE GeneReport for Unigene cluster: Hs.470728
SABiosciences Expression via Pathway-Focused PCR Array including MTX2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTX2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX2 |
Orthologs
for MTX2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MTX2 gene from 8/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MTX21 |
metaxin 2 |
80.05(n)
88.42(a) |
|
424138 XM_421989.2 XP_421989.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MTX26 |
-- |
87(a) |
1 ↔ 1 |
GL343356.1(260915-314787) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.136102 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.62(n) |
|
CA793260.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.238712 |
Transcribed sequence with moderate similarity to protein more |
73.81(n) |
|
CF550207.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG80041 , 3 |
protein-mitochondrial targeting3
CG80041 |
44(a)
(best of 2)3
52.6(n)1
45.08(a)1 |
|
76D53
401781 NM_140904.11 NP_649161.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
mtx-21 |
Protein MTX-2 |
50.07(n)
39(a) |
|
176087 NM_066288.3 NP_498689.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G190806 |
metaxin-related protein |
17(a) |
1 ↔ 1 |
2(8262750-8264964) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
19(a) |
1 ↔ 1 |
6(3427700-3432506) |
ENSEMBL Gene Tree for MTX2 (if available)
TreeFam Gene Tree for MTX2 (if available) |
Paralogs
for MTX2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTX2 gene
- MTX12 MTX32
4 SIMAP similar genes for MTX2 using alignment to 6 protein entries: MTX2_HUMAN (see all proteins):C19orf47 NDUFS7 TGFBR3 MTX1
MTX2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MTX2
PGOHUM00000233551
|
Genomic Variants
for MTX2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTX2 (177134123 - 177202753 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MTX2
2 CNVs: 78860 90135 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTX2 |
|
Disorders
/ Diseases
for MTX2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTX2 for disorders About GeneDecksing
OMIM gene information: 608555
OMIM disorders: --
2  diseases for MTX2: About MalaCardsprostate cancer prostatitis
Human Genome Epidemiology (HuGE) Navigator: MTX2 (2 documents)
Export disorders for MTX2 gene to outside databases
|
Publications
for MTX2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTX2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MTX2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane. (PubMed id 10381257)1, 2, 3 Armstrong L.C.... Bornstein P. (1999)
- MINOS1 is a conserved component of mitofilin complexe s and required for mitochondrial function and cristae organization. (PubMed id 22114354)1, 2 Alkhaja A.K....Deckers M. (2012)
- The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. (PubMed id 17624330)1, 3 Xie J....Capaldi R.A. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Conserved roles of Sam50 and metaxins in VDAC biogenesis. (PubMed id 17510655)1, 9 Kozjak-Pavlovic V....Rudel T. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for MTX2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTX2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTX2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTX2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTX2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MTX2 gene:
Search GeneIP for patents involving MTX2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTX2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 |
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| |
 |  |  |  | |
| | | | Search Tocris compounds for MTX2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MTX2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTX2 |
|  |  |  | | | | ThermoFisher Antibody for MTX2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTX2 |
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