Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTUS2 Gene

Aliases for MTUS2 Gene

  • Microtubule Associated Tumor Suppressor Candidate 2 2 3
  • Cardiac Zipper Protein 2 3 4
  • KIAA0774 2 3 4
  • Microtubule Plus-End Tracking Protein TIP150 3 4
  • Tracking Protein Of 150 KDa 3 4
  • +TIP Of 150 KDa 2 3
  • TIP150 3 4
  • CAZIP 3 4
  • Microtubule-Associated Tumor Suppressor Candidate 2 3
  • ICIS 3

External Ids for MTUS2 Gene

Previous HGNC Symbols for MTUS2 Gene

  • KIAA0774

Previous GeneCards Identifiers for MTUS2 Gene

  • GC13P028497
  • GC13P029599
  • GC13P010420

Summaries for MTUS2 Gene

GeneCards Summary for MTUS2 Gene

MTUS2 (Microtubule Associated Tumor Suppressor Candidate 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and microtubule binding. An important paralog of this gene is CCDC69.

UniProtKB/Swiss-Prot for MTUS2 Gene

  • Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTUS2 Gene

Genomics for MTUS2 Gene

Genomic Location for MTUS2 Gene

Start:
28,820,348 bp from pter
End:
29,505,947 bp from pter
Size:
685,600 bases
Orientation:
Plus strand

Genomic View for MTUS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTUS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTUS2 Gene

No data available for Regulatory Elements for MTUS2 Gene

Proteins for MTUS2 Gene

  • Protein details for MTUS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JR59-MTUS2_HUMAN
    Recommended name:
    Microtubule-associated tumor suppressor candidate 2
    Protein Accession:
    Q5JR59
    Secondary Accessions:
    • A7E292
    • B4DF81
    • O94872
    • Q08E97
    • Q5JQR3
    • Q8N5E2

    Protein attributes for MTUS2 Gene

    Size:
    1369 amino acids
    Molecular mass:
    150195 Da
    Quaternary structure:
    • Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.
    SequenceCaution:
    • Sequence=AAI50246.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA34494.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39910.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39912.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40386.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40565.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40566.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41204.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MTUS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTUS2 Gene

Proteomics data for MTUS2 Gene at MOPED

Post-translational modifications for MTUS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTUS2 Gene

No data available for DME Specific Peptides for MTUS2 Gene

Domains for MTUS2 Gene

Protein Domains for MTUS2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5JR59

UniProtKB/Swiss-Prot:

MTUS2_HUMAN :
  • Q5JR59
Family:
  • In the C-terminal section; belongs to the MTUS1 family.
genes like me logo Genes that share domains with MTUS2: view

No data available for Gene Families for MTUS2 Gene

Function for MTUS2 Gene

Molecular function for MTUS2 Gene

UniProtKB/Swiss-Prot Function: Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.

Gene Ontology (GO) - Molecular Function for MTUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008017 microtubule binding IDA 19543227
GO:0042803 protein homodimerization activity IPI 19543227
genes like me logo Genes that share ontologies with MTUS2: view

Animal Model Products

CRISPR Products

miRNA for MTUS2 Gene

miRTarBase miRNAs that target MTUS2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTUS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTUS2 Gene

Localization for MTUS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTUS2 Gene

Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTUS2 Gene COMPARTMENTS Subcellular localization image for MTUS2 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MTUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19806667
GO:0005813 colocalizes_with centrosome IDA 19543227
GO:0005881 colocalizes_with cytoplasmic microtubule IDA 19543227
genes like me logo Genes that share ontologies with MTUS2: view

Compounds for MTUS2 Gene

(9) ApexBio Compounds for MTUS2 Gene

Compound Action Cas Number
7-xylosyltaxol taxol (Paclitaxel) derivative [90332-66-4]
Colchicine Colchicine, a tubulin Inhibitor [64-86-8]
D-64131 novel inhibitor of Tubulin polymerization [74588-78-6]
Docetaxel Trihydrate inhibitor of depolymerisation of microtubules [148408-66-6]
Mc-MMAD Potent tubulin inhibitor [1401963-15-2]
MMAD Potent tubulin inhibitor [203849-91-6]
Monomethyl auristatin E Antimitotic agent [474645-27-7]
Podophyllotoxin Actions Inhibits microtubule assembly [518-28-5]
Vc-MMAD antibody drug conjugate. [1401963-17-4]
genes like me logo Genes that share compounds with MTUS2: view

Transcripts for MTUS2 Gene

Unigene Clusters for MTUS2 Gene

Microtubule associated tumor suppressor candidate 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTUS2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MTUS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTUS2 Gene

No ASD Table

Relevant External Links for MTUS2 Gene

GeneLoc Exon Structure for
MTUS2
ECgene alternative splicing isoforms for
MTUS2

Expression for MTUS2 Gene

mRNA expression in normal human tissues for MTUS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTUS2 Gene

This gene is overexpressed in Heart - Left Ventricle (10.5), Heart - Atrial Appendage (6.4), and Artery - Aorta (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MTUS2 Gene

SOURCE GeneReport for Unigene cluster for MTUS2 Gene Hs.22287

mRNA Expression by UniProt/SwissProt for MTUS2 Gene

Q5JR59-MTUS2_HUMAN
Tissue specificity: Detected in embryonic stem cells differentiating to cardiomyocytes.
genes like me logo Genes that share expressions with MTUS2: view

In Situ Assay Products

Orthologs for MTUS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTUS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTUS2 35
  • 99.32 (n)
  • 99.2 (a)
MTUS2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTUS2 35
  • 78.2 (n)
  • 72.03 (a)
MTUS2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTUS2 35
  • 83.39 (n)
  • 78.27 (a)
MTUS2 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtus2 35
  • 75.96 (n)
  • 71.24 (a)
Mtus2 16
Mtus2 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTUS2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 15 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MTUS2 35
  • 61.98 (n)
  • 51.39 (a)
MTUS2 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTUS2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9204 35
zebrafish
(Danio rerio)
Actinopterygii mtus2 36
  • 28 (a)
OneToMany
MTUS2 (2 of 2) 36
  • 57 (a)
OneToMany
Species with no ortholog for MTUS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTUS2 Gene

ENSEMBL:
Gene Tree for MTUS2 (if available)
TreeFam:
Gene Tree for MTUS2 (if available)

Paralogs for MTUS2 Gene

Paralogs for MTUS2 Gene

Selected SIMAP similar genes for MTUS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MTUS2: view

Variants for MTUS2 Gene

Sequence variations from dbSNP and Humsavar for MTUS2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs167832 -- 29,069,384(-) tgccc(A/G)acctg intron-variant
rs167833 -- 29,052,345(-) TGCCA(C/T)CATGC intron-variant
rs167834 -- 29,063,483(-) TTACA(C/T)GATTG intron-variant
rs182740 -- 29,025,692(-) TCCCA(A/G)ATACC reference, synonymous-codon
rs184467 -- 29,048,499(-) tgaga(A/C)cctat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTUS2 Gene

Variant ID Type Subtype PubMed ID
dgv341e199 CNV Deletion 23128226
esv2747194 CNV Deletion 23290073
nsv899957 CNV Loss 21882294
esv2747195 CNV Deletion 23290073
esv2656848 CNV Deletion 23128226
nsv455851 CNV Loss 19166990
esv2674542 CNV Deletion 23128226
esv24526 CNV Loss 19812545
nsv819299 CNV Loss 19587683
dgv1570n71 CNV Loss 21882294
nsv976 CNV Loss 18451855
esv2747196 CNV Deletion 23290073
esv2674147 CNV Deletion 23128226
esv270829 CNV Insertion 20981092
esv2404495 CNV Deletion 18987734
esv4893 CNV Deletion 18987735
esv1000206 CNV Deletion 20482838
nsv64203 CNV Loss 16902084
esv1638300 CNV Deletion 17803354
esv8958 CNV Loss 19470904
esv2747198 CNV Deletion 23290073
esv2671942 CNV Deletion 23128226
nsv978 CNV Loss 18451855
esv2673934 CNV Deletion 23128226
esv2747199 CNV Deletion 23290073
esv2747200 CNV Deletion 23290073
esv2747201 CNV Deletion 23290073
esv1626402 CNV Deletion 17803354
esv2604500 CNV Deletion 19546169
esv2028726 CNV Deletion 18987734
esv5230 CNV Deletion 18987735
esv2747202 CNV Deletion 23290073
esv992274 CNV Deletion 20482838
esv2428654 CNV Deletion 19546169
esv9584 CNV Loss 19470904
nsv64217 CNV Loss 16902084
esv2747203 CNV Deletion 23290073
esv2747204 CNV Deletion 23290073
esv2747205 CNV Deletion 23290073
esv275414 CNV Loss 21479260
esv270952 CNV Insertion 20981092
esv272935 CNV Insertion 20981092
esv2747206 CNV Deletion 23290073
nsv899960 CNV Gain 21882294
esv2592607 CNV Deletion 19546169
esv2747207 CNV Deletion 23290073
esv2747209 CNV Deletion 23290073
esv1003602 CNV Deletion 20482838

Relevant External Links for MTUS2 Gene

HapMap Linkage Disequilibrium report
MTUS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTUS2 Gene

Disorders for MTUS2 Gene

Relevant External Links for MTUS2

Genetic Association Database (GAD)
MTUS2
Human Genome Epidemiology (HuGE) Navigator
MTUS2
genes like me logo Genes that share disorders with MTUS2: view

No data available for UniProtKB/Swiss-Prot for MTUS2 Gene

Publications for MTUS2 Gene

  1. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PMID: 19543227) Jiang K. … Yao X. (EMBO Rep. 2009) 2 3 4
  2. CAZIP, a novel protein expressed in the developing heart and nervous system. (PMID: 19806667) Du Puy L. … Passier R. (Dev. Dyn. 2009) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PMID: 22558309) Wong K.A. … O'Bryan J.P. (PLoS ONE 2012) 3

Products for MTUS2 Gene

Sources for MTUS2 Gene

Back to Top

Content