Aliases for MTUS2 Gene
Aliases for MTUS2 Gene
External Ids for MTUS2 Gene
- HGNC: 20595
- Entrez Gene: 23281
- Ensembl: ENSG00000132938
- UniProtKB: Q5JR59
Previous HGNC Symbols for MTUS2 Gene
- KIAA0774
Previous GeneCards Identifiers for MTUS2 Gene
- GC13P028497
- GC13P029599
- GC13P010420
Summaries for MTUS2 Gene
GeneCards Summary for MTUS2 Gene
MTUS2 (Microtubule Associated Tumor Suppressor Candidate 2) is a Protein Coding gene. Diseases associated with MTUS2 include Hypertrophy Of Breast. GO annotations related to this gene include protein homodimerization activity and microtubule binding. An important paralog of this gene is CCDC69.
UniProtKB/Swiss-Prot for MTUS2 Gene
-
Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTUS2 Gene
Genomics for MTUS2 Gene
Regulatory Elements for MTUS2 Gene
Enhancers for MTUS2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around MTUS2 on UCSC Golden Path with GeneCards custom track
Promoters for MTUS2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around MTUS2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MTUS2 Gene
- Chromosome:
- 13
- Start:
- 28,820,348 bp from pter
- End:
- 29,505,947 bp from pter
- Size:
- 685,600 bases
- Orientation:
- Plus strand
Genomic View for MTUS2 Gene
Genes around MTUS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q12.3 by Ensembl
- 13q12.3 by Entrez Gene
- 13q12.3 by HGNC
MTUS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTUS2 Gene
Proteins for MTUS2 Gene
-
Protein details for MTUS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JR59-MTUS2_HUMAN
- Recommended name:
- Microtubule-associated tumor suppressor candidate 2
- Protein Accession:
- Q5JR59
- A7E292
- B4DF81
- O94872
- Q08E97
- Q5JQR3
- Q8N5E2
Protein attributes for MTUS2 Gene
- Size:
- 1369 amino acids
- Molecular mass:
- 150195 Da
- Quaternary structure:
-
- Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.
- SequenceCaution:
-
- Sequence=AAI50246.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA34494.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39910.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39912.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40386.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40565.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40566.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41204.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for MTUS2 Gene
Post-translational modifications for MTUS2 Gene
Other Protein References for MTUS2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MTUS2
- Novus Biologicals Antibodies for MTUS2
- Abcam antibodies for MTUS2
- Invitrogen Antibodies for MTUS2
- antibodies-online Antibodies for MTUS2: See all 21
- GeneTex MTUS2 antibody for MTUS2
-
Custom Antibody ServicesProSci Antibodies for MTUS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for MTUS2
Protein Products
-
OriGene Purified Proteins for MTUS2
- Search Origene for MassSpec and Protein Over-expression Lysates for MTUS2
- Origene Custom Protein Services for MTUS2
- antibodies-online Proteins for MTUS2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MTUS2
- Abcam proteins for MTUS2
Assay Products
No data available for DME Specific Peptides for MTUS2 Gene
Domains & Families for MTUS2 Gene
Protein Domains for MTUS2 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for MTUS2 Gene
Graphical View of Domain Structure for InterPro Entry
Q5JR59- Family:
-
- In the C-terminal section; belongs to the MTUS1 family.
No data available for Gene Families for MTUS2 Gene
Function for MTUS2 Gene
Molecular function for MTUS2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008017 | microtubule binding | IDA | 19543227 |
| GO:0042803 | protein homodimerization activity | IPI | 19543227 |
Phenotypes for MTUS2 Gene
- GenomeRNAi human phenotypes for MTUS2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MTUS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTUS2 gene
- Search ViGene Biosciences for MTUS2
CRISPR Products
-
OriGene CRISPR knockouts for MTUS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTUS2
- GenScript: Design CRISPR guide RNA sequences for MTUS2
miRNA for MTUS2 Gene
- miRTarBase miRNAs that target MTUS2
miRNA Products
- Search ViGene Biosciences for MTUS2
Clone Products
- OriGene clones in human for MTUS2
- OriGene ORF clones in human,mouse,rat for MTUS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MTUS2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MTUS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTUS2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTUS2 Gene
Localization for MTUS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTUS2 Gene
- Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 4 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 19806667 |
Pathways & Interactions for MTUS2 Gene
More details on SuperPathways for MTUS2
No Data Available
Interacting Proteins for MTUS2 Gene
Selected Interacting proteins:
Q5JR59-MTUS2_HUMAN
ENSP00000392057
for MTUS2 Gene via
MINT
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for MTUS2 Gene
Transcripts for MTUS2 Gene
mRNA/cDNA for MTUS2 Gene
- (7) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (30) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MTUS2 Gene
- Microtubule associated tumor suppressor candidate 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MTUS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTUS2
- GenScript: Design CRISPR guide RNA sequences for MTUS2
miRNA Products
- Search ViGene Biosciences for MTUS2
Clone Products
- OriGene clones in human for MTUS2
- OriGene ORF clones in human,mouse,rat for MTUS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for MTUS2 Gene
mRNA differential expression in normal tissues according to GTEx for MTUS2 Gene
This gene is overexpressed in Heart - Left Ventricle (x10.5), Heart - Atrial Appendage (x6.4), and Artery - Aorta (x5.8).
This gene is overexpressed in Fetal heart (41.6) and Fetal Brain (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTUS2 Gene
SOURCE GeneReport for Unigene cluster for MTUS2 Gene Hs.22287
mRNA Expression by UniProt/SwissProt for MTUS2 Gene
Q5JR59-MTUS2_HUMAN
Tissue specificity:
Detected in embryonic stem cells differentiating to cardiomyocytes.
Primer Products
-
OriGene qPCR primer pairs for MTUS2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MTUS2 Gene
Orthologs for MTUS2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MTUS2 35 |
|
||
| MTUS2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | MTUS2 35 |
|
||
| MTUS2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Mtus2 35 |
|
||
| Mtus2 16 |
|
||||
| Mtus2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | MTUS2 35 |
|
||
| MTUS2 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | MTUS2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | MTUS2 35 |
|
||
| MTUS2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | MTUS2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.9204 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mtus2 36 |
|
OneToMany | |
| MTUS2 (2 of 2) 36 |
|
OneToMany |
- Species with no ortholog for MTUS2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MTUS2 Gene
(1) SIMAP similar genes for MTUS2 Gene using alignment to 2 proteins:
Variants for MTUS2 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs12874207 | - | 29,324,670(+) | ATCTC(A/C)TAAGA | reference, missense | |
| VAR_058831 | - | ||||
| rs167832 | -- | 29,069,384(-) | tgccc(A/G)acctg | intron-variant | |
| rs167833 | -- | 29,052,345(-) | TGCCA(C/T)CATGC | intron-variant | |
| rs167834 | -- | 29,063,483(-) | TTACA(C/T)GATTG | intron-variant |
Residual Variation Intolerance Score:
94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.21;
76.08% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MTUS2 Gene
Disorders for MTUS2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypertrophy of breast |
|
|
Search MTUS2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MTUS2
No data available for UniProtKB/Swiss-Prot and Genatlas for MTUS2 Gene
Publications for MTUS2 Gene
- TIP150 interacts with and targets MCAK at the microtubule plus ends. (PMID: 19543227) Jiang K. … Yao X. (EMBO Rep. 2009) 2 3 4 67
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
- Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction. (PMID: 24847103) Xia P. … Yao X. (J Mol Cell Biol 2014) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
Products for MTUS2 Gene
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- Custom Antibody ServicesOriGene Antibodies for MTUS2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MTUS2
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- OriGene qPCR primer pairs for MTUS2
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- Novus Biologicals Antibodies for MTUS2
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for MTUS2
- Abcam proteins for MTUS2
- Search for Assays for MTUS2 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for MTUS2: See all 21
- Search antibodies-online for kits
- antibodies-online Proteins for MTUS2: See all 3
- Search antibodies-online for peptides
- GeneTex MTUS2 antibody for MTUS2
- Search GeneTex for Proteins for MTUS2
- ViGene Biosciences adenoviral particle packaged cDNA for MTUS2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MTUS2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MTUS2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MTUS2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MTUS2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MTUS2 gene
- Search ViGene Biosciences for MTUS2
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- Santa Cruz Biotechnology (SCBT) Antibodies for MTUS2
- Search Santa Cruz Biotechnology (SCBT) for MTUS2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MTUS2
- Custom Antibody ServicesProSci Antibodies for MTUS2
Sources for MTUS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
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- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
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- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
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- (130) diseasecard
- (131) NIH Rare Diseases
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- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
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- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon