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Aliases for MTUS2 Gene

Aliases for MTUS2 Gene

  • Microtubule Associated Scaffold Protein 2 2 3 5
  • Cardiac Zipper Protein 2 3 4
  • KIAA0774 2 3 4
  • Microtubule Associated Tumor Suppressor Candidate 2 2 3
  • Microtubule Plus-End Tracking Protein TIP150 3 4
  • Tracking Protein Of 150 KDa 3 4
  • +TIP Of 150 KDa 2 3
  • TIP150 3 4
  • CAZIP 3 4
  • Microtubule-Associated Tumor Suppressor Candidate 2 3
  • ICIS 3

External Ids for MTUS2 Gene

Previous HGNC Symbols for MTUS2 Gene

  • KIAA0774

Previous GeneCards Identifiers for MTUS2 Gene

  • GC13P028497
  • GC13P029599
  • GC13P010420

Summaries for MTUS2 Gene

GeneCards Summary for MTUS2 Gene

MTUS2 (Microtubule Associated Scaffold Protein 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and microtubule binding. An important paralog of this gene is MTUS1.

UniProtKB/Swiss-Prot for MTUS2 Gene

  • Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.

Additional gene information for MTUS2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTUS2 Gene

Genomics for MTUS2 Gene

Regulatory Elements for MTUS2 Gene

Enhancers for MTUS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H029454 1.4 Ensembl ENCODE dbSUPER 11.1 +636.2 636166 3.6 HDAC1 TBP PKNOX1 ARNT NFRKB RAD21 TCF12 ZNF143 FOS ETV6 MTUS2-AS1 MTUS2 PIR44178
GH13H029580 1.2 Ensembl ENCODE dbSUPER 10.4 +762.3 762256 3.4 STAT1 TAL1 MAFG ZIC2 ZKSCAN1 ZFHX2 JUND ZNF316 ZNF366 GLIS1 MTUS2-AS1 MTUS2 UBL3 GC13P029586 PIR32808
GH13H029702 0.9 Ensembl ENCODE 11.2 +882.9 882949 1.5 TBP JUN HLF CEBPB MAX EP300 ZNF623 NFIL3 JUND CEBPA SLC7A1 MTUS2-AS1 MTUS2 LOC105370139 UBL3
GH13H029124 0.6 ENCODE 16.6 +305.3 305317 1.9 BCL11A IKZF1 CHD1 JUNB RUNX3 BATF SPI1 MTUS2 MTUS2-AS2
GH13H029519 0.8 ENCODE dbSUPER 12 +702.2 702203 5.8 JUND POLR2A ZNF366 JUN NBN YBX1 MTUS2-AS1 MTUS2 SLC7A1 EIF4A1P7 GC13M029513 PIR35309 PIR32808
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTUS2 on UCSC Golden Path with GeneCards custom track

Promoters for MTUS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060478 -348 801 CTCF MXI1 RB1 REST RAD21 CTBP1 EGR1 GLIS1 HMGN3 ZBTB26

Genomic Locations for MTUS2 Gene

Genomic Locations for MTUS2 Gene
685,600 bases
Plus strand

Genomic View for MTUS2 Gene

Genes around MTUS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTUS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTUS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTUS2 Gene

Proteins for MTUS2 Gene

  • Protein details for MTUS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microtubule-associated tumor suppressor candidate 2
    Protein Accession:
    Secondary Accessions:
    • A7E292
    • B4DF81
    • O94872
    • Q08E97
    • Q5JQR3
    • Q8N5E2

    Protein attributes for MTUS2 Gene

    1369 amino acids
    Molecular mass:
    150195 Da
    Quaternary structure:
    • Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.
    • Sequence=AAI50246.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA34494.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39910.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39912.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40386.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40565.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40566.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41204.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MTUS2 Gene


neXtProt entry for MTUS2 Gene

Post-translational modifications for MTUS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTUS2 Gene

Domains & Families for MTUS2 Gene

Gene Families for MTUS2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTUS2 Gene


Graphical View of Domain Structure for InterPro Entry



  • In the C-terminal section; belongs to the MTUS1 family.
  • In the C-terminal section; belongs to the MTUS1 family.
genes like me logo Genes that share domains with MTUS2: view

Function for MTUS2 Gene

Molecular function for MTUS2 Gene

UniProtKB/Swiss-Prot Function:
Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.

Phenotypes From GWAS Catalog for MTUS2 Gene

Gene Ontology (GO) - Molecular Function for MTUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008017 microtubule binding IDA 19543227
GO:0042803 protein homodimerization activity IPI 19543227
genes like me logo Genes that share ontologies with MTUS2: view

Phenotypes for MTUS2 Gene

genes like me logo Genes that share phenotypes with MTUS2: view

Animal Model Products

miRNA for MTUS2 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTUS2 Gene

Localization for MTUS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTUS2 Gene

Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTUS2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (3)
  • Microtubules (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19806667
GO:0005737 cytoplasm IEA --
GO:0005813 colocalizes_with centrosome IDA 19543227
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with MTUS2: view

Pathways & Interactions for MTUS2 Gene

SuperPathways for MTUS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTUS2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTUS2 Gene

Drugs & Compounds for MTUS2 Gene

No Compound Related Data Available

Transcripts for MTUS2 Gene

Unigene Clusters for MTUS2 Gene

Microtubule associated tumor suppressor candidate 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTUS2 Gene

No ASD Table

Relevant External Links for MTUS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTUS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTUS2 Gene

mRNA differential expression in normal tissues according to GTEx for MTUS2 Gene

This gene is overexpressed in Heart - Left Ventricle (x10.5), Heart - Atrial Appendage (x6.4), and Artery - Aorta (x5.8).

Protein differential expression in normal tissues from HIPED for MTUS2 Gene

This gene is overexpressed in Fetal heart (41.6) and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MTUS2 Gene

Protein tissue co-expression partners for MTUS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTUS2 Gene:


SOURCE GeneReport for Unigene cluster for MTUS2 Gene:


mRNA Expression by UniProt/SwissProt for MTUS2 Gene:

Tissue specificity: Detected in embryonic stem cells differentiating to cardiomyocytes.

Evidence on tissue expression from TISSUES for MTUS2 Gene

  • Pancreas(4.4)
  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with MTUS2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTUS2 Gene

Orthologs for MTUS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTUS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTUS2 33 34
  • 99.32 (n)
(Canis familiaris)
Mammalia MTUS2 33 34
  • 83.39 (n)
(Monodelphis domestica)
Mammalia MTUS2 34
  • 83 (a)
(Bos Taurus)
Mammalia MTUS2 34 33
  • 78.2 (n)
(Mus musculus)
Mammalia Mtus2 33 16 34
  • 75.96 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 15 (a)
(Gallus gallus)
Aves MTUS2 33 34
  • 61.98 (n)
(Anolis carolinensis)
Reptilia MTUS2 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9204 33
(Danio rerio)
Actinopterygii MTUS2 (2 of 2) 34
  • 57 (a)
mtus2 34
  • 28 (a)
Species where no ortholog for MTUS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTUS2 Gene

Gene Tree for MTUS2 (if available)
Gene Tree for MTUS2 (if available)

Paralogs for MTUS2 Gene

Paralogs for MTUS2 Gene

(1) SIMAP similar genes for MTUS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MTUS2: view

Variants for MTUS2 Gene

Sequence variations from dbSNP and Humsavar for MTUS2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000000306 -- 29,280,743(+) CAAGT(A/G)GTAAT intron-variant
rs1000000488 -- 29,006,246(+) CACTC(C/T)GCACC intron-variant
rs1000004691 -- 29,000,776(+) CACTT(C/T)TCCCT intron-variant
rs1000007064 -- 29,408,234(+) TGATT(-/A)AAAAA intron-variant
rs1000008285 -- 29,124,870(+) TAGGA(A/G)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTUS2 Gene

Variant ID Type Subtype PubMed ID
esv3354076 CNV duplication 20981092
esv3334629 CNV insertion 20981092
esv3249829 CNV deletion 24192839
esv3249718 CNV deletion 24192839
esv275414 CNV loss 21479260
esv2747209 CNV deletion 23290073
esv2747207 CNV deletion 23290073
esv2747206 CNV deletion 23290073
esv2747205 CNV deletion 23290073
esv2747204 CNV deletion 23290073
esv2747203 CNV deletion 23290073
esv2747202 CNV deletion 23290073
esv2747201 CNV deletion 23290073
esv2747200 CNV deletion 23290073
esv2747199 CNV deletion 23290073
esv2747198 CNV deletion 23290073
esv2747196 CNV deletion 23290073
esv2747195 CNV deletion 23290073
esv2747194 CNV deletion 23290073
esv2674542 CNV deletion 23128226
esv2674147 CNV deletion 23128226
esv2673934 CNV deletion 23128226
esv2671942 CNV deletion 23128226
esv2656848 CNV deletion 23128226
esv2604500 CNV deletion 19546169
esv2592607 CNV deletion 19546169
esv24526 CNV loss 19812545
esv2428654 CNV deletion 19546169
esv2404495 CNV deletion 18987734
esv2028726 CNV deletion 18987734
esv1638300 CNV deletion 17803354
esv1626402 CNV deletion 17803354
esv1003602 CNV deletion 20482838
esv1000206 CNV deletion 20482838
dgv938n106 CNV deletion 24896259
dgv937n106 CNV deletion 24896259
dgv936n106 CNV deletion 24896259
dgv539e212 CNV loss 25503493
dgv341e199 CNV deletion 23128226
nsv1113554 CNV deletion 24896259
nsv1113553 CNV deletion 24896259
nsv1071090 CNV deletion 25765185
nsv1071089 CNV deletion 25765185
nsv1070162 CNV deletion 25765185
nsv1069740 CNV deletion 25765185
esv992274 CNV deletion 20482838
esv9584 CNV loss 19470904
esv8958 CNV loss 19470904
esv5230 CNV loss 18987735
esv4893 CNV loss 18987735
esv3631652 CNV loss 21293372
esv3631649 CNV loss 21293372
esv3631648 CNV loss 21293372
esv3580586 CNV loss 25503493
esv3550245 CNV deletion 23714750
esv3550243 CNV deletion 23714750
esv3550242 CNV deletion 23714750
esv3445341 CNV insertion 20981092
esv3436963 CNV insertion 20981092
esv3364547 CNV insertion 20981092
nsv983571 CNV duplication 23825009
nsv978 CNV deletion 18451855
nsv977223 CNV duplication 23825009
nsv976100 CNV duplication 23825009
nsv976 CNV deletion 18451855
nsv958145 CNV deletion 24416366
nsv958117 CNV deletion 24416366
nsv958113 CNV deletion 24416366
nsv958111 CNV deletion 24416366
nsv819299 CNV loss 19587683
nsv64217 CNV deletion 16902084
nsv64203 CNV deletion 16902084
nsv561392 CNV loss 21841781
nsv561391 CNV loss 21841781
nsv473604 CNV novel sequence insertion 20440878
nsv455851 CNV loss 19166990
nsv1149258 CNV deletion 26484159
nsv1149120 CNV deletion 26484159
nsv1149047 CNV deletion 26484159
nsv1147021 CNV deletion 26484159
nsv1144671 CNV deletion 24896259
nsv1139797 CNV deletion 24896259
nsv1139108 CNV deletion 24896259
nsv1138208 CNV deletion 24896259
nsv1134298 CNV deletion 24896259
nsv1134297 CNV deletion 24896259
nsv1134296 CNV deletion 24896259
nsv1129545 CNV tandem duplication 24896259
nsv1127321 CNV deletion 24896259
nsv1124870 CNV deletion 24896259

Variation tolerance for MTUS2 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTUS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTUS2 Gene

Disorders for MTUS2 Gene

Relevant External Links for MTUS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MTUS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTUS2 Gene

Publications for MTUS2 Gene

  1. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PMID: 19543227) Jiang K … Yao X (EMBO reports 2009) 2 3 4 60
  2. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. (PMID: 20889352) Rodrigues-Ferreira S … Nahmias C (Trends in endocrinology and metabolism: TEM 2010) 2 3 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. CAZIP, a novel protein expressed in the developing heart and nervous system. (PMID: 19806667) Du Puy L … Passier R (Developmental dynamics : an official publication of the American Association of Anatomists 2009) 3 4 60
  5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 60

Products for MTUS2 Gene

Sources for MTUS2 Gene

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