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MTUS2 Gene

protein-coding   GIFtS: 47
GCID: GC13P029599

Microtubule Associated Tumor Suppressor Candidate 2

(Previous name: KIAA0774)
(Previous symbol: KIAA0774)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule Associated Tumor Suppressor Candidate 21 2     Tracking Protein Of 150 KDa2 3
KIAA07741 2 3     CAZIP2 3
Cardiac Zipper Protein1 2 3     TIP1502 3
+TIP Of 150 KDa1 2     ICIS2
Microtubule Plus-End Tracking Protein TIP1502 3     Microtubule-Associated Tumor Suppressor Candidate 22

External Ids:    HGNC: 205951   Entrez Gene: 232812   Ensembl: ENSG000001329387   UniProtKB: Q5JR593   

Export aliases for MTUS2 gene to outside databases

Previous GC identifers: GC13P028497 GC13P010420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTUS2 Gene:
MTUS2 (microtubule associated tumor suppressor candidate 2) is a protein-coding gene. GO annotations related to this gene include microtubule binding and protein homodimerization activity. An important paralog of this gene is MTUS1.

UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59
Function: Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end
of microtubules. May regulate the dynamics of microtubules at their growing distal tip




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MTUS2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MTUS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTUS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12.3

MTUS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTUS2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P029599:  view genomic region     (about GC identifiers)

Start:
29,598,748 bp from pter      End:
30,080,084 bp from pter
Size:
481,337 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59 (See protein sequence)
Recommended Name: Microtubule-associated tumor suppressor candidate 2  
Size: 1369 amino acids; 150195 Da
Subunit: Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and
KIF2C to microtubules
Sequence caution: Sequence=AAI50246.1; Type=Erroneous initiation; Sequence=BAA34494.2; Type=Erroneous initiation;
Sequence=CAI39910.1; Type=Erroneous gene model prediction; Sequence=CAI39912.1; Type=Erroneous gene model
prediction; Sequence=CAI40386.1; Type=Erroneous gene model prediction; Sequence=CAI40565.1; Type=Erroneous gene
model prediction; Sequence=CAI40566.1; Type=Erroneous gene model prediction; Sequence=CAI41204.1; Type=Erroneous
gene model prediction;
Secondary accessions: A7E292 B4DF81 O94872 Q08E97 Q5JQR3 Q8N5E2
Alternative splicing: 3 isoforms:  Q5JR59-2   Q5JR59-3   Q5JR59-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTUS2: NX_Q5JR59

Explore proteomics data for MTUS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTUS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001028774.2  NP_056048.1  

    ENSEMBL proteins: 
     ENSP00000392057   ENSP00000370186   ENSP00000445403  

    MTUS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MTUS2
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    Novus Biologicals MTUS2 Proteins
    Novus Biologicals MTUS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MTUS2 

    MTUS2 Antibody Products:

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    ThermoFisher Antibodies for MTUS2
    LSBio Antibodies in human, mouse, rat for MTUS2

    MTUS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MTUS2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MTUS2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5JR59

    UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59
    Similarity: In the C-terminal section; belongs to the MTUS1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTUS2_HUMAN, Q5JR59
    Function: Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end
    of microtubules. May regulate the dynamics of microtubules at their growing distal tip

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19060904
    GO:0008017microtubule binding IDA19543227
    GO:0042803protein homodimerization activity IPI19543227
         
    Find genes that share ontologies with MTUS2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTUS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTUS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTUS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTUS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTUS2:
    hsa-mir-124-3p (MIRT022821), hsa-mir-146a-5p (MIRT021240)

    Block miRNA regulation of human, mouse, rat MTUS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTUS2 (see all 54):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-488 hsa-miR-138-2* hsa-miR-507 hsa-miR-1184 hsa-miR-649 hsa-miR-525-3p
    SwitchGear 3'UTR luciferase reporter plasmidMTUS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTUS2
    Predesigned siRNA for gene silencing in human, mouse, rat MTUS2

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MTUS2 (NM_001033602)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTUS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTUS2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MTUS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTUS2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTUS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTUS2_HUMAN, Q5JR59: Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal
    tip (the plus-end) of microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813colocalizes with centrosome IDA19543227
    GO:0005881colocalizes with cytoplasmic microtubule IDA19543227

    Find genes that share ontologies with MTUS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTUS2
    Interactions:

        Search GeneGlobe Interaction Network for MTUS2

    Selected Interacting proteins for MTUS2 (Q5JR591, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPRE1Q156911, 2, 3EBI-742948,EBI-1004115 MINT-7256299 MINT-7256149 MINT-7256258 MINT-7256350 MINT-7256110 MINT-7256165 MINT-7256121 I2D: score=1 
    KIF2CQ996611, 2, 3EBI-742948,EBI-1642317 MINT-7256299 MINT-7256258 MINT-7256235 MINT-7256361 MINT-7256216 MINT-7256202 I2D: score=1 
    PLK4O004442, 3MINT-67204 I2D: score=5 
    ZNF655Q8N7202, 3MINT-67594 I2D: score=5 
    C1orf216Q8TAB52, 3MINT-67819 I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    9 ApexBio Compounds for MTUS2     About this table
    CompoundAction CAS #
    7-xylosyltaxoltaxol (Paclitaxel) derivative[90332-66-4]
    ColchicineColchicine, a tubulin Inhibitor[64-86-8]
    D-64131novel inhibitor of Tubulin polymerization[74588-78-6]
    Docetaxel Trihydrateinhibitor of depolymerisation of microtubules[148408-66-6]
    Mc-MMADPotent tubulin inhibitor[1401963-15-2]
    MMADPotent tubulin inhibitor[203849-91-6]
    Monomethyl auristatin EAntimitotic agent[474645-27-7]
    PodophyllotoxinActions Inhibits microtubule assembly[518-28-5]
    Vc-MMADantibody drug conjugate[1401963-17-4]

    Browse Tocris compounds for MTUS2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTUS2 gene (2 alternative transcripts): 
    NM_001033602.2  NM_015233.5  

    Unigene Cluster for MTUS2:

    Microtubule associated tumor suppressor candidate 2
    Hs.22287  [show with all ESTs]
    Unigene Representative Sequence: NM_001033602
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431530(uc001usl.4 uc010tdq.2) ENST00000255289 ENST00000380808(uc001usm.4 uc010aau.3)
    ENST00000400542 ENST00000467990 ENST00000542829
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTUS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTUS2 (see all 54):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-488 hsa-miR-138-2* hsa-miR-507 hsa-miR-1184 hsa-miR-649 hsa-miR-525-3p
    SwitchGear 3'UTR luciferase reporter plasmidMTUS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTUS2
    Predesigned siRNA for gene silencing in human, mouse, rat MTUS2
    Clone
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    OriGene clones in human, mouse for MTUS2 (see all 12)
    OriGene ORF clones in mouse, rat for MTUS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MTUS2 (NM_001033602)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTUS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTUS2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MTUS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTUS2
      QuantiTect SYBR Green Assays in human, mouse, rat MTUS2
      QuantiFast Probe-based Assays in human, mouse, rat MTUS2

    Additional mRNA sequence: 

    AB018317.2 AK293970.1 AK301633.1 AK302516.1 BC032481.1 BC119654.1 BC119655.1 BC129985.1 
    BC150245.1 

    6 DOTS entries:

    DT.100743967  DT.209340  DT.311611  DT.120783141  DT.100658767  DT.91814423 

    Selected AceView cDNA sequences (see all 30):

    BF512653 T26932 CF552274 AB018317 CB151991 BC032481 BI838225 T26418 
    AA021163 BX101662 CB153757 AI818409 BM906724 AL702629 BU788127 AJ709151 
    BG218308 AA962508 R17729 BE671488 R17357 H04911 AA443334 R41801 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTUS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGACAAG
    MTUS2 Expression
    About this image


    MTUS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Epithalamus
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Left Ventricle
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
    MTUS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTUS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22287

    UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59
    Tissue specificity: Detected in embryonic stem cells differentiating to cardiomyocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTUS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MTUS2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtus21 , 5 microtubule associated tumor suppressor candidate 21, 5 75.96(n)1
    71.24(a)1
      5 (87.82 cM)5
    775211  NM_029920.71  NP_084196.41 
     1479573205 
    chicken
    (Gallus gallus)
    Aves MTUS21 microtubule associated tumor suppressor candidate 2 61.98(n)
    51.39(a)
      418923  XM_417117.3  XP_417117.2 
    lizard
    (Anolis carolinensis)
    Reptilia MTUS26
    microtubule associated tumor suppressor candidate ...
    70(a)
    1 ↔ 1
    3(185057937-185085564)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.92042 Transcribed sequence with weak similarity to protein more 75.11(n)    BX684473.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MTUS2 (2 of 2)6
    mtus26
    microtubule associated tumor suppressor candidate ...
    microtubule associated tumor suppressor candidate ...
    57(a)
    28(a)
    1 ↔ many
    1 ↔ many
    15(3319595-3331916) ENSDARG00000074984
    10(24935660-25053513) ENSDARG00000062347


    ENSEMBL Gene Tree for MTUS2 (if available)
    TreeFam Gene Tree for MTUS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTUS2 gene
    MTUS12  CCDC692  
    1 SIMAP similar gene for MTUS2 using alignment to 2 protein entries:     MTUS2_HUMAN (see all proteins):
    CCDC69

    Find genes that share paralogs with MTUS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTUS2 (see all 10795)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs599166531,2
    C--10460457(+) TTTTT-/TTTT  
     
    /TTTTTT
    GACAG
    1 -- int11NA 2
    rs1118482361,2
    C--10915260(+) TGAGC-/CCTT  
            
    CCTTC
    1 -- int11Minor allele frequency- CCTT:0.00CSA 2
    rs1809266461,2
    --29596752(+) GTGCAC/TGTGTG 1 -- us2k10--------
    rs1157355231,2
    F--29596790(+) AAAGTG/ATGGAA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1838562821,2
    --29596811(+) CTCCAC/TTGGGG 1 -- us2k10--------
    rs1117369061,2
    C,F--29596827(+) GGTGAC/TGGGGC 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1885795751,2
    --29596888(+) ACTCAC/TAATAG 1 -- us2k10--------
    rs1403575751,2
    C--29596989(+) AACTCC/TTTGGG 1 -- us2k10--------
    rs1454374461,2
    --29597007(+) ATAACC/GCTGAT 1 -- us2k10--------
    rs1147963691,2
    F--29597228(+) TGGTAG/CTTATG 1 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for MTUS2 (29598748 - 29848748 bp, first 250kb of MTUS2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MTUS2 (see all 48):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747206CNV Deletion23290073
    esv4893CNV Deletion18987735
    esv2747205CNV Deletion23290073
    esv2028726CNV Deletion18987734
    esv2747199CNV Deletion23290073
    esv992274CNV Deletion20482838
    esv2747209CNV Deletion23290073
    esv1626402CNV Deletion17803354
    esv5230CNV Deletion18987735
    esv2747207CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTUS2
    DNA2.0 Custom Variant and Variant Library Synthesis for MTUS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with MTUS2           About GenesLikeMe

    Genetic Association Database (GAD): MTUS2
    Human Genome Epidemiology (HuGE) Navigator: MTUS2 (1 document)

    Export disorders for MTUS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTUS2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with MTUS2)
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    world of online information

    1. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PubMed id 19543227)1, 2, 3 Jiang K....Yao X. (EMBO Rep. 2009)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. CAZIP, a novel protein expressed in the developing heart and nervous system. (PubMed id 19806667)1, 2 Du Puy L.... Passier R. (Dev. Dyn. 2009)
    4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    5. Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300/CBP-associated factor (PCAF) orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis. (PubMed id 23595990)1 Ward T....Yao X. (J. Biol. Chem. 2013)
    6. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. (PubMed id 22754043)1 Byrne E.M....Martin N.G. (Sleep 2012)
    9. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. (PubMed id 19901119)1 TreviA+o L.R....Relling M.V. (J. Clin. Oncol. 2009)
    10. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23281 HGNC: 20595 AceView: KIAA0774 Ensembl:ENSG00000132938 euGenes: HUgn23281
    ECgene: MTUS2 H-InvDB: MTUS2

    (According to HUGE)
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    HUGE: KIAA0774

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTUS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTUS2 gene:
    Search GeneIP for patents involving MTUS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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