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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MTUS2 Gene

protein-coding GIFtS: 45
GCID: GC13P029599

microtubule associated tumor suppressor candidate 2

(Previous name: KIAA0774 )
(Previous symbol: KIAA0774)

Search for MTUS2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Microtubule Associated Tumor Suppressor Candidate 2¹ ²		Cardiac Zipper Protein² ³
CAZIP¹ ² ³		Microtubule Plus-End Tracking Protein TIP150² ³
KIAA0774¹ ² ³		Tracking Protein Of 150 KDa² ³
TIP150¹ ² ³		+TIP Of 150 KDa²
ICIS¹ ²		Microtubule-Associated Tumor Suppressor Candidate 2²

External Ids:	HGNC: 20595¹	Entrez Gene: 23281²	Ensembl: ENSG00000132938⁷	UniProtKB: Q5JR59³

Export aliases for MTUS2 gene to outside databases

Previous GC identifers: GC13P028497 GC13P010420

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59

Function: Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of

microtubules. May regulate the dynamics of microtubules at their growing distal tip

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MTUS2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MTUS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTUS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3 Ensembl cytogenetic band: 13q12.3 HGNC cytogenetic band: 13q12.3

MTUS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTUS2 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P029599: view genomic region (about GC identifiers)

Start:	29,598,748 bp from pter	End:	30,080,084 bp from pter
Size:	481,337 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59 (See protein sequence)

Recommended Name: Microtubule-associated tumor suppressor candidate 2

Size: 1369 amino acids; 150195 Da

Subunit: Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to

microtubules

Subcellular location: Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip

(the plus-end) of microtubules

Sequence caution: Sequence=AAI50246.1; Type=Erroneous initiation; Sequence=BAA34494.2; Type=Erroneous initiation;

Sequence=CAI39910.1; Type=Erroneous gene model prediction; Sequence=CAI39912.1; Type=Erroneous gene model prediction;

Sequence=CAI40386.1; Type=Erroneous gene model prediction; Sequence=CAI40565.1; Type=Erroneous gene model prediction;

Sequence=CAI40566.1; Type=Erroneous gene model prediction; Sequence=CAI41204.1; Type=Erroneous gene model prediction;

Secondary accessions: A7E292 B4DF81 O94872 Q08E97 Q5JQR3 Q8N5E2

Alternative splicing: 3 isoforms: Q5JR59-2 Q5JR59-3 Q5JR59-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTUS2: NX_Q5JR59

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5JR59

MTUS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001028774.2 NP_056048.1

ENSEMBL proteins:

ENSP00000392057 ENSP00000370186 ENSP00000445403

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MTUS2 OriGene Protein Over-expression Lysate: MTUS2 OriGene Custom Protein Services for MTUS2
	GenScript Custom Purified and Recombinant Proteins Services for MTUS2
	Novus Biologicals MTUS2 Proteins Novus Biologicals MTUS2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MTUS2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005813	colocalizes with centrosome	IDA	19543227
GO:0005881	colocalizes with cytoplasmic microtubule	IDA	19543227

MTUS2 for ontologies About GeneDecksing

MTUS2 Antibody Products:

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	Novus Biologicals MTUS2 Antibodies
	Search for Antibodies for MTUS2 at Abcam
	Uscn Antibodies for MTUS2
	ThermoFisher Antibodies for MTUS2

Assay Products for MTUS2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MTUS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MTUS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5JR59

UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59

Similarity: In the C-terminal section; belongs to the MTUS1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59

Function: Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of

microtubules. May regulate the dynamics of microtubules at their growing distal tip

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MTUS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTUS2
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate MTUS2 (see all 54):
		hsa-miR-3678-3p hsa-miR-579 hsa-miR-488 hsa-miR-138-2* hsa-miR-507 hsa-miR-1184 hsa-miR-649 hsa-miR-525-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MTUS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTUS2 OriGene shRNA RFP: MTUS2 OriGene siRNA: MTUS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTUS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MTUS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTUS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTUS2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MTUS2 (NM_001033602)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTUS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTUS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MTUS2
		Search LifeMap BioReagents cell lines for MTUS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTUS2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19543227
GO:0008017	microtubule binding	IDA	19543227
GO:0042803	protein homodimerization activity	IPI	19543227

MTUS2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MTUS2

5/25 Interacting proteins for MTUS2 (Q5JR59^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPRE1	Q15691²^,³	MINT-7256299 MINT-7256149 MINT-7256258 MINT-7256350 MINT-7256110 MINT-7256165 MINT-7256121 I2D: score=1
KIF2C	Q99661²^,³	MINT-7256299 MINT-7256258 MINT-7256235 MINT-7256361 MINT-7256216 MINT-7256202 I2D: score=1
PLK4	O00444²^,³	MINT-67204 I2D: score=5
ZNF655	Q8N720²^,³	MINT-67594 I2D: score=5
C1orf216	Q8TAB5²^,³	MINT-67819 I2D: score=4

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MTUS2
Search CenterWatch for drugs/clinical trials and news about MTUS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MTUS2 gene (2 alternative transcripts):

NM_001033602.2 NM_015233.5

Unigene Cluster for MTUS2:

Microtubule associated tumor suppressor candidate 2

Hs.22287 [show with all ESTs]

Unigene Representative Sequence: NM_001033602

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000431530(uc001usl.4 uc010tdq.2) ENST00000255289 ENST00000380808(uc001usm.4 uc010aau.3)

ENST00000400542 ENST00000467990 ENST00000542829

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MTUS2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTUS2
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate MTUS2 (see all 54):
		hsa-miR-3678-3p hsa-miR-579 hsa-miR-488 hsa-miR-138-2* hsa-miR-507 hsa-miR-1184 hsa-miR-649 hsa-miR-525-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MTUS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTUS2 OriGene shRNA RFP: MTUS2 OriGene siRNA: MTUS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTUS2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTUS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTUS2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MTUS2 (NM_001033602)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTUS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTUS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTUS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MTUS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTUS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTUS2

Additional cDNA sequence:

AB018317.2 AK293970.1 AK301633.1 AK302516.1 BC032481.1 BC119654.1 BC119655.1 BC129985.1

BC150245.1

6 DOTS entries:

DT.100743967 DT.209340 DT.311611 DT.120783141 DT.100658767 DT.91814423

24/30 AceView cDNA sequences (see all 30):

BF512653 CB151991 BC032481 AB018317 T26932 CF552274 BU788127 BX101662

T26418 BI838225 AA021163 AI818409 AL702629 BM906724 AJ709151 CB153757

R17729 AA962508 BE671488 BG218308 R17357 AA443334 H04911 AA248815

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MTUS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGGACAAG

About this image

MTUS2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Bone

Brain

Brain

Brain

Eye

Interventricular Septum

Heart

Left Ventricle

Heart

Right Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)

Bone

See MTUS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTUS2

SOURCE GeneReport for Unigene cluster: Hs.22287

UniProtKB/Swiss-Prot: MTUS2_HUMAN, Q5JR59

Tissue specificity: Detected in embryonic stem cells differentiating to cardiomyocytes

SABiosciences Custom PCR Arrays for MTUS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTUS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MTUS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTUS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTUS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTUS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MTUS2 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MTUS2¹	microtubule associated tumor suppressor candidate 2	61.84(n) 51.22(a)		418923 XM_417117.2 XP_417117.2
lizard (Anolis carolinensis)	Reptilia	MTUS2⁶ --	--	71(a) 28(a)	1 ↔ 1 possible ortholog	3(185057937-185085564) 3(185057522-185389033)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.9204²	Transcribed sequence with weak similarity to protein more	75.11(n)		BX684473.1
zebrafish (Danio rerio)	Actinopterygii	CABZ01053588.1⁶ mtus2⁶	-- microtubule associated tumor suppressor candidate ...	56(a) 33(a)	1 ↔ many 1 ↔ many	15(3319595-3331916) 10(24995231-25052835)
fruit fly (Drosophila melanogaster)	Insecta	toc⁶	toucan	8(a)	possible ortholog	2L(3068345-3144613)

ENSEMBL Gene Tree for MTUS2 (if available)
TreeFam Gene Tree for MTUS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MTUS2 gene

MTUS1² CCDC69²

1 SIMAP similar gene for MTUS2 using alignment to 2 protein entries: MTUS2_HUMAN (see all proteins):

CCDC69

MTUS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58667275^1,2	C	--	10805504(+)	`TGTTT-/GTTT TGAGA`	1	--	int¹		0	--	--	--	--
rs5802523^1,2	C	--	10868564(+)	`AGTAG-/AAAT AAATA`	1	--	int¹		0	--	--	--	--
rs200214158^1,2	C	--	10868567(+)	`AGAAAG/TANNNN`	1	--	int¹		0	--	--	--	--
rs77772073^1,2	C,	--	10887036(+)	`GGCTGG/TCATTG`	2	A S	mis¹		0	--	--	--	--
rs74044830^1,2	C,	--	10887543(+)	`GAAACG/ACTGGT`	1	--	int¹		2		WA	120
rs78951476^1,2	F,	--	10887957(+)	`TCTCCA/CGTGTA`	1	--	int¹		1		WA	118
rs17601608^1,2	C,F,H,	--	10888121(+)	`AGCGAT/CATCAC`	1	--	int¹		23		NA NS EA WA	2508
rs77448766^1,2		--	10888528(+)	`CCCTGG/AGTTGG`	1	--	int¹		1		NA	120
rs180926646^1,2		--	29596752(+)	`GTGCAC/TGTGTG`	1	--	us2k¹		0	--	--	--	--
rs115735523^1,2	F,	--	29596790(+)	`AAAGTG/ATGGAA`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for MTUS2 (29598748 - 29848748 bp, first 250kb of MTUS2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for MTUS2
1 CNV: 58620
15/17 Indels (see all 17): 42509 45154 25229 76295 39965 66409 11663 39964 45153 42800 86757 11662 101690 76294 61306

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTUS2

DNA2.0 Custom Variant and Variant Library Synthesis for MTUS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MTUS2 for disorders About MalaCards

MTUS2 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: MTUS2 (1 document)

Export disorders for MTUS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MTUS2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with MTUS2)

Utopia: connect your pdf to the dynamic
world of online information

TIP150 interacts with and targets MCAK at the microtubule plus ends. (PubMed id 19543227)^{1, 2, 3} Jiang K....Yao X. (2009)
CAZIP, a novel protein expressed in the developing heart and nervous system. (PubMed id 19806667)^{1, 2} Du Puy L.... Passier R. (2009)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2} Nagase T.... Ohara O. (1998)
Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)¹ Wong K.A....O'Bryan J.P. (2012)
A genome-wide association study of caffeine-related sl eep disturbance: confirmation of a role for a common variant in the adenosine re ceptor. (PubMed id 22754043)¹ Byrne E.M....Martin N.G. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. (PubMed id 17704809)¹ Cheng Z....Yao X. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23281	HGNC: 20595	AceView: KIAA0774	Ensembl:ENSG00000132938	euGenes: HUgn23281
ECgene: MTUS2	H-InvDB: MTUS2

(According to HUGE)
About This Section

HUGE: KIAA0774

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MTUS2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MTUS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MTUS2 gene:
Search GeneIP for patents involving MTUS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	OriGene Antibodies for MTUS2		OriGene shRNA RFP for MTUS2
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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MTUS2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MTUS2

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTUS2

	SwitchGear 3'UTR luciferase reporter plasmids for MTUS2
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ThermoFisher Antibodies for MTUS2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTUS2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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MTUS2 Gene

microtubule associated tumor suppressor candidate 2

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MTUS2 Gene

microtubule associated tumor suppressor candidate 2

Aliasesfor MTUS2 gene

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Genomic Viewsfor MTUS2 gene

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Protein Domains /Familiesfor MTUS2 gene

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Genome Databases showing MTUS2 gene

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Specialized Databases showing MTUS2 gene

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Aliases
for MTUS2 gene

Summaries
for MTUS2 gene

Genomic Views
for MTUS2 gene

Proteins
for MTUS2 gene

Protein Domains /
Families
for MTUS2 gene

Function
for MTUS2 gene

Pathways & Interactions
for MTUS2 gene

Drugs & Compounds
for MTUS2 gene

Transcripts
for MTUS2 gene

Expression
for MTUS2 gene

Orthologs
for MTUS2 gene

Paralogs
for MTUS2 gene

Genomic Variants
for MTUS2 gene

Disorders / Diseases
for MTUS2 gene

Publications
for MTUS2 gene

Intellectual Property
for MTUS2 gene

Products
for MTUS2 gene