Aliases for MTUS1 Gene
External Ids for MTUS1 Gene
Previous GeneCards Identifiers for MTUS1 Gene
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTUS1 Gene
MTUS1 (Microtubule Associated Tumor Suppressor 1) is a Protein Coding gene. Diseases associated with MTUS1 include Hepatocellular Carcinoma and Familial Breast Cancer. An important paralog of this gene is MTUS2.
UniProtKB/Swiss-Prot for MTUS1 Gene
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.