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MTUS1 Gene

protein-coding   GIFtS: 55
GCID: GC08M017501

Microtubule Associated Tumor Suppressor 1

(Previous name: mitochondrial tumor suppressor 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule Associated Tumor Suppressor 11 2     AT2 Receptor-Binding Protein2 3
Mitochondrial Tumor Suppressor 11 3     ICIS2
AT2 Receptor-Interacting Protein1 2     MP442
AT2R Binding Protein1 2     Erythroid Differentiation-Related2
Mitochondrial Tumor Suppressor Gene 11 2     Microtubule-Associated Tumor Suppressor 12
Angiotensin-II Type 2 Receptor-Interacting Protein2 3     Transcription Factor MTSG12
ATBP2 3     GK13
ATIP2 3     KIAA12883
MTSG12 3     

External Ids:    HGNC: 297891   Entrez Gene: 575092   Ensembl: ENSG000001294227   OMIM: 6095895   UniProtKB: Q9ULD23   

Export aliases for MTUS1 gene to outside databases

Previous GC identifers: GC08M017512 GC08M017545 GC08M016045


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTUS1 Gene:
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2)
receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants
encoding different isoforms have been found for this gene. One of the transcript variants has been shown to
encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other
variants may encode nuclear or transmembrane proteins but it has not been determined whether they also
participate in AT2 signaling pathways. (provided by RefSeq, Jul 2008)

GeneCards Summary for MTUS1 Gene:
MTUS1 (microtubule associated tumor suppressor 1) is a protein-coding gene. Diseases associated with MTUS1 include hepatocellular carcinoma, and cowpox. An important paralog of this gene is MTUS2.

UniProtKB/Swiss-Prot: MTUS1_HUMAN, Q9ULD2
Function: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell
surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1
inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces
tumor growth

Gene Wiki entry for MTUS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTUS1 gene promoter:
         USF1   MEF-2   USF2   Lmo2   USF-1:USF-2   MEF-2A   POU2F1   POU2F1a   USF-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): MTUS1 promoter sequence
   Search Chromatin IP Primers for MTUS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTUS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

MTUS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTUS1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M017501:  view genomic region     (about GC identifiers)

Start:
17,501,303 bp from pter      End:
17,658,426 bp from pter
Size:
157,124 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MTUS1_HUMAN, Q9ULD2 (See protein sequence)
Recommended Name: Microtubule-associated tumor suppressor 1  
Size: 1270 amino acids; 141397 Da
Subunit: Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with
microtubules
Sequence caution: Sequence=AAH07328.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH33842.1; Type=Erroneous initiation; Sequence=BAB14894.1; Type=Erroneous initiation;
Secondary accessions: A8K135 B2RBJ6 B3KWJ9 B4DH03 B9EGA1 D3DSP8 Q63HJ6 Q659F4 Q6PK49 Q6URW7
Q8N4M6 Q8WTT9 Q9H7T2
Alternative splicing: 7 isoforms:  Q9ULD2-1   Q9ULD2-2   Q9ULD2-3   Q9ULD2-4   Q9ULD2-5   Q9ULD2-6   Q9ULD2-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTUS1: NX_Q9ULD2

Explore proteomics data for MTUS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTUS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001001924.1  NP_001001925.1  NP_001001931.1  NP_001159865.1  NP_065800.1  

    ENSEMBL proteins: 
     ENSP00000297488   ENSP00000431016   ENSP00000371285   ENSP00000262102   ENSP00000430167  
     ENSP00000371293   ENSP00000445738   ENSP00000382921   ENSP00000371286  

    MTUS1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTUS1

    MTUS1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MTUS1
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    LSBio Antibodies in human, mouse, rat for MTUS1

    MTUS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for MTUS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9ULD2

    UniProtKB/Swiss-Prot: MTUS1_HUMAN, Q9ULD2
    Similarity: Belongs to the MTUS1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTUS1_HUMAN, Q9ULD2
    Function: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell
    surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1
    inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces
    tumor growth
    Induction: Isoform 1 is down-regulated in invasive breast carcinomas (at protein level)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTUS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTUS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTUS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTUS1

    miRNA
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    miRTarBase miRNAs that target MTUS1:
    hsa-let-7b-5p (MIRT052348), hsa-let-7a-5p (MIRT052541), hsa-mir-98-5p (MIRT027822), hsa-mir-125a-5p (MIRT004388), hsa-mir-183-5p (MIRT047094), hsa-mir-1296-5p (MIRT036127), hsa-mir-335-5p (MIRT018728)

    Block miRNA regulation of human, mouse, rat MTUS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTUS1 (see all 63):
    hsa-miR-361-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-let-7d hsa-miR-449a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidMTUS1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MTUS1
    Predesigned siRNA for gene silencing in human, mouse, rat MTUS1

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MTUS1 (NM_001001924)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTUS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTUS1

    Cell Line
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    ESI BIO PureStem Progenitors for MTUS1: 
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTUS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTUS1_HUMAN, Q9ULD2: Mitochondrion. Golgi apparatus (By similarity). Cell membrane (By similarity). Nucleus (By
    similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin-II (By similarity)
    MTUS1_HUMAN, Q9ULD2: Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
    cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge
    during cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion5
    nucleus3
    golgi apparatus2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005815microtubule organizing center IEA--

    MTUS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTUS1
    Interactions:

        GeneGlobe Interaction Network for MTUS1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MTUS1 (Q9ULD23 ENSP000002621024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTR2P500523, ENSP000003609734I2D: score=2 STRING: ENSP00000360973
    ORC4ENSP000002641694STRING: ENSP00000264169
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0071375cellular response to peptide hormone stimulus IEA--

    MTUS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTUS1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTUS1 gene (6 alternative transcripts): 
    NM_001001924.2  NM_001001925.2  NM_001001931.2  NM_001166393.1  NM_020749.4  NM_001001927.1  

    Unigene Cluster for MTUS1:

    Microtubule associated tumor suppressor 1
    Hs.7946  [show with all ESTs]
    Unigene Representative Sequence: NM_001001924
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000517413 ENST00000297488(uc003wxs.3) ENST00000520196 ENST00000381861(uc003wxt.3)
    ENST00000262102(uc010lsy.3) ENST00000519263 ENST00000518889 ENST00000518792
    ENST00000523471 ENST00000518713 ENST00000522757 ENST00000521772 ENST00000524371
    ENST00000517818 ENST00000524044 ENST00000523183 ENST00000519066 ENST00000521635

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTUS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTUS1 (see all 63):
    hsa-miR-361-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-429 hsa-let-7d hsa-miR-449a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidMTUS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTUS1
    Predesigned siRNA for gene silencing in human, mouse, rat MTUS1
    Clone
    Products:
         
    OriGene clones in human, mouse for MTUS1 (see all 30)
    OriGene ORF clones in mouse, rat for MTUS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MTUS1 (NM_001001924)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTUS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTUS1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MTUS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTUS1
      QuantiTect SYBR Green Assays in human, mouse, rat MTUS1
      QuantiFast Probe-based Assays in human, mouse, rat MTUS1

    Additional mRNA sequence: 

    AB033114.1 AF086371.1 AF121259.1 AF293357.1 AF394227.1 AK000172.1 AK024357.1 AK026661.1 
    AK125188.1 AK289750.1 AK294860.1 AK304105.1 AK310871.1 AK314692.1 AY363099.1 BC007328.2 
    BC017740.1 BC033842.1 BC098381.1 BC117564.1 BC136320.1 BC142971.1 BC171765.1 FJ458440.1 
    FJ458441.1 

    Selected DOTS entries (see all 28):

    DT.451623  DT.95273567  DT.91763573  DT.40132178  DT.101984530  DT.100798474  DT.100798469  DT.100798472 
    DT.121480902  DT.205143  DT.91763564  DT.121480804  DT.95273569  DT.95315733  DT.40316779  DT.95273566 
    DT.100705640  DT.121480846  DT.121480854  DT.432549  DT.95139854  DT.101969567  DT.121480829  DT.121480850 

    Selected AceView cDNA sequences (see all 332):

    CA405996 NM_001001931 AI810681 Z41694 AI810416 AI149364 AW293730 AA621202 
    BU609177 CD679291 BU733517 BM702509 BM665224 BM314677 BM662029 BM968524 
    BU685931 BC017740 CA397428 NM_020749 AA470902 AB033114 NM_001001925 AI125878 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTUS1 (see all 25)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ·
    SP1:                                                                          -           -     -     -                 -     -     -     -     -     -     -   
    SP2:                                                                                                                                      -     -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                            -     -                 -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 20c · 20d · 20e ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c · 27d ^ 28a · 28b · 28c · 28d ^ 29 ^ 30 ^ 31a · 31b ^ 32a · 32b ^
    SP1:  -     -     -     -           -     -     -                 -     -                             -                                               -         
    SP2:  -     -     -     -           -     -     -                 -     -                             -                                               -         
    SP3:                                            -                 -     -                             -                                                         
    SP4:  -     -     -     -           -     -     -                 -     -                                                                                       
    SP5:                                -     -     -                 -     -                                                                                       

    ExUns: 33a · 33b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MTUS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTUS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAATGCAA
    MTUS1 Expression
    About this image


    MTUS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
    MTUS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTUS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7946

    UniProtKB/Swiss-Prot: MTUS1_HUMAN, Q9ULD2
    Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in
    ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform
    1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is
    the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed
    in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain

        Custom PCR Arrays for MTUS1
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    QuantiFast Probe-based Assays in human, mouse, rat MTUS1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTUS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MTUS1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtus11 , 5 mitochondrial tumor suppressor 11, 5 75.82(n)1
    66.09(a)1
      8 (23.89 cM)5
    1021031  NM_001005863.21  NP_001005863.11 
     409909185 
    chicken
    (Gallus gallus)
    Aves MTUS16
    microtubule associated tumor suppressor 1
    67(a)
    1 ↔ 1
    4(62557973-62607677)
    lizard
    (Anolis carolinensis)
    Reptilia MTUS16
    microtubule associated tumor suppressor 1
    60(a)
    1 ↔ 1
    5(109056416-109117182)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986972 ICIS 75.68(n)    AY352638.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mtus1a6
    MTUS1 (1 of 2)6
    microtubule associated tumor suppressor 1
    26(a)
    18(a)
    1 ↔ many
    1 ↔ many
    14(31167099-31227101) ENSDARG00000071562
    1(15282565-15359635) ENSDARG00000034105


    ENSEMBL Gene Tree for MTUS1 (if available)
    TreeFam Gene Tree for MTUS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTUS1 gene
    MTUS22  CCDC692  

    MTUS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTUS1 (see all 5505)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871037041,2,,4
    CHepatocellular carcinoma (HCC)4 --17825438(+) TGCATG/TAAGAG 8 N H mis10--------
    rs617337031,2,,4
    C,FHepatocellular carcinoma (HCC)4 --17867881(+) ACCCTG/TAAGGC 4 K Q mis11Minor allele frequency- T:0.03NS 76
    VAR_0351784
    Hepatocellular carcinoma (HCC)4--see VAR_0351782 A S mis40--------
    VAR_0351844
    Hepatocellular carcinoma (HCC)4--see VAR_0351842 Q R mis40--------
    rs672532081,2
    C--16058544(+) AAAAC-/C/CG  
            
    CCCCC
    5 -- int10--------
    rs570626841,2
    C--16067606(+) TTTTT-/T/TT  
            
    AAATC
    5 -- int11NA 2
    rs29379021,2
    C,F,A,H--16097649(-) GGAGGG/AGGTCA 5 -- int1 trp38Minor allele frequency- A:0.42NA WA CSA EA 370
    rs4041391,2
    C,F,H--16097650(-) AGGAGC/GAGGTC 5 -- int17Minor allele frequency- G:0.50NA WA EA 366
    rs665618221,2
    C--16102404(+) CAAACAG/-AAATT 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs360663771,2
    C--16102405(+) AAACA-/GAAATTC 4 -- int10--------

    HapMap Linkage Disequilibrium report for MTUS1 (17501303 - 17658426 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MTUS1 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674241CNV Deletion23128226
    nsv821096CNV Deletion20802225
    esv2659440CNV Deletion23128226
    esv2421533CNV Deletion20811451
    esv2605243CNV Insertion19546169
    nsv6098CNV Insertion18451855
    nsv471727CNV Loss16327809
    nsv526978CNV Loss19592680
    nsv514481CNV Loss21397061
    esv34867CNV Loss17911159

    Human Gene Mutation Database (HGMD): MTUS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTUS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MTUS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609589    OMIM disorders: --

    UniProtKB/Swiss-Prot: MTUS1_HUMAN, Q9ULD2
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The
    major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV)
    infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note=The
    gene represented in this entry may be involved in disease pathogenesis

  • 15 diseases for MTUS1:    
    About MalaCards
    hepatocellular carcinoma    cowpox    familial breast cancer    esophageal squamous cell carcinoma
    squamous cell carcinoma    adenoma    esophagitis    breast cancer
    thyroiditis    prostate cancer    multiple myeloma    myeloma
    endotheliitis    neuronitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for MTUS1:
    Cowpox

    MTUS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTUS1
    Human Genome Epidemiology (HuGE) Navigator: MTUS1 (3 documents)

    Export disorders for MTUS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTUS1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with MTUS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new tumor suppressor gene located at chromosome 8p21.3-22. (PubMed id 12692079)1, 2, 3 Seibold S.... Marx M. (FASEB J. 2003)
    2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    3. Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP. (PubMed id 16887298)1, 2, 9 Di Benedetto M....Nahmias C. (Gene 2006)
    4. Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. (PubMed id 16650523)1, 2, 9 Di Benedetto M....Nahmias C. (Mol. Cell. Endocrinol. 2006)
    5. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. (PubMed id 15123706)1, 2, 9 Nouet S.... Nahmias C. (J. Biol. Chem. 2004)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis. (PubMed id 19794912)1, 2 Rodrigues-Ferreira S.... Nahmias C. (PLoS ONE 2009)
    8. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    9. Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk. (PubMed id 17301065)1, 4 Frank B....Burwinkel B. (Carcinogenesis 2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57509 HGNC: 29789 AceView: MTUS1 Ensembl:ENSG00000129422 euGenes: HUgn57509
    ECgene: MTUS1 H-InvDB: MTUS1

    (According to HUGE)
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    HUGE: KIAA1288

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTUS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTUS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTUS1 gene:
    Search GeneIP for patents involving MTUS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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