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Aliases for MTUS1 Gene

Aliases for MTUS1 Gene

  • Microtubule Associated Tumor Suppressor 1 2 3 5
  • Angiotensin-II Type 2 Receptor-Interacting Protein 3 4
  • Mitochondrial Tumor Suppressor Gene 1 2 3
  • AT2 Receptor-Interacting Protein 2 3
  • Mitochondrial Tumor Suppressor 1 2 4
  • AT2 Receptor-Binding Protein 3 4
  • AT2R Binding Protein 2 3
  • MTSG1 3 4
  • ATBP 3 4
  • ATIP 3 4
  • Microtubule-Associated Tumor Suppressor 1 3
  • Erythroid Differentiation-Related 3
  • Transcription Factor MTSG1 3
  • KIAA1288 4
  • ICIS 3
  • MP44 3
  • GK1 4

External Ids for MTUS1 Gene

Previous GeneCards Identifiers for MTUS1 Gene

  • GC08M017512
  • GC08M017545
  • GC08M016045
  • GC08M017501

Summaries for MTUS1 Gene

Entrez Gene Summary for MTUS1 Gene

  • This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTUS1 Gene

MTUS1 (Microtubule Associated Tumor Suppressor 1) is a Protein Coding gene. Diseases associated with MTUS1 include Hepatocellular Carcinoma and Familial Breast Cancer. An important paralog of this gene is MTUS2.

UniProtKB/Swiss-Prot for MTUS1 Gene

  • Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.

Gene Wiki entry for MTUS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTUS1 Gene

Genomics for MTUS1 Gene

Regulatory Elements for MTUS1 Gene

Enhancers for MTUS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F017846 1.7 FANTOM5 Ensembl ENCODE 21.1 -48.3 -48304 5.1 TBP ATF1 ARID4B FEZF1 ZSCAN9 RARA RFX5 ZNF121 ZNF366 EGR2 MTUS1 ENSG00000253671 ENSG00000253215 FGL1 ENSG00000253944 ASAH1 PCM1 MTMR7 GC08M017832 GC08P017880
GH08F017786 1.1 Ensembl ENCODE 20.7 +5.8 5826 18.3 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 FOS PAF1 ENSG00000253671 MTUS1 ENSG00000253944 CNOT7 ASAH1 GC08M017800 GC08M017804 GC08P017779
GH08F017838 0.7 ENCODE 19.9 -37.5 -37479 1.2 POLR3A MTUS1 ENSG00000253671 CNOT7 ENSG00000253944 ASAH1 GC08M017832 GC08P017815
GH08F017604 1.3 FANTOM5 Ensembl ENCODE 17.7 +195.2 195150 2.5 SOX13 SOX5 KLF1 JUN NR3C1 ZFHX2 POLR2A MYNN ZNF547 TCF7 MTUS1 PDGFRL MTMR7 ENSG00000277466 MIR548V
GH08F017607 1.1 FANTOM5 Ensembl ENCODE 16 +191.2 191182 4.8 SIN3A FEZF1 ZNF2 YY1 ZNF121 FOS DEK TSHZ1 PPARG MIER3 MTUS1 MTMR7 PDGFRL LOC105379299 ENSG00000277466 MIR548V
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MTUS1 on UCSC Golden Path with GeneCards custom track

Promoters for MTUS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001386805 -81 3800 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 PAF1

Genomic Location for MTUS1 Gene

Chromosome:
8
Start:
17,643,794 bp from pter
End:
17,801,220 bp from pter
Size:
157,427 bases
Orientation:
Minus strand

Genomic View for MTUS1 Gene

Genes around MTUS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTUS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTUS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTUS1 Gene

Proteins for MTUS1 Gene

  • Protein details for MTUS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULD2-MTUS1_HUMAN
    Recommended name:
    Microtubule-associated tumor suppressor 1
    Protein Accession:
    Q9ULD2
    Secondary Accessions:
    • A8K135
    • B2RBJ6
    • B3KWJ9
    • B4DH03
    • B9EGA1
    • D3DSP8
    • Q63HJ6
    • Q659F4
    • Q6PK49
    • Q6URW7
    • Q8N4M6
    • Q8WTT9
    • Q9H7T2

    Protein attributes for MTUS1 Gene

    Size:
    1270 amino acids
    Molecular mass:
    141397 Da
    Quaternary structure:
    • Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules.
    SequenceCaution:
    • Sequence=AAH07328.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH33842.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14894.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTUS1 Gene

neXtProt entry for MTUS1 Gene

Post-translational modifications for MTUS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for MTUS1

No data available for DME Specific Peptides for MTUS1 Gene

Domains & Families for MTUS1 Gene

Protein Domains for MTUS1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9ULD2

UniProtKB/Swiss-Prot:

MTUS1_HUMAN :
  • Belongs to the MTUS1 family.
Family:
  • Belongs to the MTUS1 family.
genes like me logo Genes that share domains with MTUS1: view

No data available for Gene Families for MTUS1 Gene

Function for MTUS1 Gene

Molecular function for MTUS1 Gene

UniProtKB/Swiss-Prot Function:
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
UniProtKB/Swiss-Prot Induction:
Isoform 1 is down-regulated in invasive breast carcinomas (at protein level).
genes like me logo Genes that share phenotypes with MTUS1: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTUS1 Gene

Localization for MTUS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTUS1 Gene

Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.
Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTUS1 Gene COMPARTMENTS Subcellular localization image for MTUS1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
mitochondrion 4
nucleus 4
golgi apparatus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MTUS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with MTUS1: view

Pathways & Interactions for MTUS1 Gene

SuperPathways for MTUS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTUS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTUS1 Gene

Transcripts for MTUS1 Gene

Unigene Clusters for MTUS1 Gene

Microtubule associated tumor suppressor 1:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTUS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ·
SP1: - - - - - - - - - - -
SP2: - - - -
SP3:
SP4: - - - - - - - - -
SP5:
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - - - - - - -
SP14: - - -
SP15: - - - -
SP16:
SP17:
SP18:
SP19: - - - -
SP20:
SP21:
SP22: - - - - -
SP23:
SP24:
SP25: - -

ExUns: 20c · 20d · 20e ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c · 27d ^ 28a · 28b · 28c · 28d ^ 29 ^ 30 ^ 31a · 31b ^ 32a · 32b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - - - -
SP12: - - -
SP13:
SP14:
SP15: - - - - - - - - - - - - -
SP16: -
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP23:
SP24:
SP25:

ExUns: 33a · 33b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for MTUS1 Gene

GeneLoc Exon Structure for
MTUS1
ECgene alternative splicing isoforms for
MTUS1

Expression for MTUS1 Gene

mRNA expression in normal human tissues for MTUS1 Gene

Protein differential expression in normal tissues from HIPED for MTUS1 Gene

This gene is overexpressed in Serum (34.0) and Pancreas (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTUS1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MTUS1 Gene:

MTUS1

SOURCE GeneReport for Unigene cluster for MTUS1 Gene:

Hs.7946

mRNA Expression by UniProt/SwissProt for MTUS1 Gene:

Q9ULD2-MTUS1_HUMAN
Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.
genes like me logo Genes that share expression patterns with MTUS1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MTUS1 Gene

Orthologs for MTUS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTUS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTUS1 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTUS1 34 35
  • 86.48 (n)
dog
(Canis familiaris)
Mammalia MTUS1 34 35
  • 84.27 (n)
mouse
(Mus musculus)
Mammalia Mtus1 34 16 35
  • 75.82 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911065 34
  • 69.33 (n)
oppossum
(Monodelphis domestica)
Mammalia MTUS1 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTUS1 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTUS1 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTUS1 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13519 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398697 34
zebrafish
(Danio rerio)
Actinopterygii mtus1a 35
  • 26 (a)
OneToMany
MTUS1 (1 of 2) 35
  • 18 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6933 34
Species where no ortholog for MTUS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTUS1 Gene

ENSEMBL:
Gene Tree for MTUS1 (if available)
TreeFam:
Gene Tree for MTUS1 (if available)

Paralogs for MTUS1 Gene

Paralogs for MTUS1 Gene

genes like me logo Genes that share paralogs with MTUS1: view

Variants for MTUS1 Gene

Sequence variations from dbSNP and Humsavar for MTUS1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs187103704 Hepatocellular carcinoma (HCC) [MIM:114550] 17,713,220(+) TGCAT(G/T)AAGAG nc-transcript-variant, reference, missense
rs567116808 Hepatocellular carcinoma (HCC) [MIM:114550] 17,646,137(+) AAAGC(C/T)GCCTT reference, missense, splice-acceptor-variant
rs61733703 Hepatocellular carcinoma (HCC) [MIM:114550] 17,755,585(+) ACCCT(A/G/T)AAGGC nc-transcript-variant, reference, missense, stop-gained
VAR_035178 Hepatocellular carcinoma (HCC) [MIM:114550]
rs10086264 -- 17,667,762(+) TATGC(A/G)AGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTUS1 Gene

Variant ID Type Subtype PubMed ID
dgv12040n54 CNV loss 21841781
dgv12041n54 CNV loss 21841781
dgv12042n54 CNV loss 21841781
dgv12043n54 CNV loss 21841781
dgv7120n100 CNV gain 25217958
dgv7121n100 CNV gain 25217958
esv23139 CNV gain 19812545
esv2421533 CNV deletion 20811451
esv2605243 CNV insertion 19546169
esv2659440 CNV deletion 23128226
esv2674241 CNV deletion 23128226
esv2759600 CNV loss 17122850
esv2761186 CNV loss 21179565
esv2762735 CNV gain 21179565
esv2764066 CNV gain+loss 21179565
esv3310470 CNV novel sequence insertion 20981092
esv3340868 CNV insertion 20981092
esv3378123 CNV duplication 20981092
esv3394562 CNV insertion 20981092
esv34867 CNV loss 17911159
esv3543157 CNV deletion 23714750
esv3543158 CNV deletion 23714750
esv3616489 CNV loss 21293372
esv3616492 CNV loss 21293372
esv3616495 CNV loss 21293372
esv3616497 CNV loss 21293372
esv3616498 CNV loss 21293372
esv3616499 CNV gain 21293372
esv3616500 CNV gain 21293372
esv3891363 CNV loss 25118596
esv3891364 CNV gain 25118596
nsv1029903 CNV loss 25217958
nsv1075540 CNV deletion 25765185
nsv1077024 CNV deletion 25765185
nsv1137350 CNV deletion 24896259
nsv1137351 CNV deletion 24896259
nsv1137352 CNV deletion 24896259
nsv471727 CNV loss 16327809
nsv510133 OTHER sequence alteration 20534489
nsv512032 CNV loss 21212237
nsv514481 CNV loss 21397061
nsv516696 CNV loss 19592680
nsv526978 CNV loss 19592680
nsv6098 CNV insertion 18451855
nsv610681 CNV loss 21841781
nsv610692 CNV loss 21841781
nsv610700 CNV gain 21841781
nsv610701 CNV gain 21841781
nsv818613 CNV loss 17921354
nsv819748 CNV gain 19587683
nsv821096 CNV deletion 20802225
nsv8307 CNV loss 18304495
nsv8308 CNV gain 18304495
nsv831247 CNV gain 17160897
nsv831249 CNV loss 17160897
nsv831250 CNV loss 17160897
nsv957083 CNV deletion 24416366

Variation tolerance for MTUS1 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.10; 80.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTUS1 Gene

Human Gene Mutation Database (HGMD)
MTUS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTUS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTUS1 Gene

Disorders for MTUS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MTUS1 Gene - From: Swiss-Prot and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search MTUS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MTUS1_HUMAN
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269 PubMed:16650523}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Relevant External Links for MTUS1

Genetic Association Database (GAD)
MTUS1
Human Genome Epidemiology (HuGE) Navigator
MTUS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTUS1
genes like me logo Genes that share disorders with MTUS1: view

No data available for Genatlas for MTUS1 Gene

Publications for MTUS1 Gene

  1. Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. (PMID: 16650523) Di Benedetto M. … Nahmias C. (Mol. Cell. Endocrinol. 2006) 3 4 22 64
  2. Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP. (PMID: 16887298) Di Benedetto M. … Nahmias C. (Gene 2006) 3 4 22 64
  3. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. (PMID: 15123706) Nouet S. … Nahmias C. (J. Biol. Chem. 2004) 3 4 22 64
  4. Identification of a new tumor suppressor gene located at chromosome 8p21.3-22. (PMID: 12692079) Seibold S. … Marx M. (FASEB J. 2003) 2 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64

Products for MTUS1 Gene

Sources for MTUS1 Gene

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