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Aliases for MTTP Gene

Aliases for MTTP Gene

  • Microsomal Triglyceride Transfer Protein 2 3 5
  • Microsomal Triglyceride Transfer Protein (Large Polypeptide, 88kDa) 2 3
  • MTP 3 4
  • Microsomal Triglyceride Transfer Protein (Large Polypeptide, 88kD) 2
  • Microsomal Triglyceride Transfer Protein Large Subunit 3
  • ABL 3

External Ids for MTTP Gene

Previous HGNC Symbols for MTTP Gene

  • MTP

Previous GeneCards Identifiers for MTTP Gene

  • GCMTU990051
  • GC04P100854
  • GC04P100715
  • GC04P100485
  • GC04P096223

Summaries for MTTP Gene

Entrez Gene Summary for MTTP Gene

  • MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTTP Gene

MTTP (Microsomal Triglyceride Transfer Protein) is a Protein Coding gene. Diseases associated with MTTP include Abetalipoproteinemia and Abdominal Obesity-Metabolic Syndrome 1. Among its related pathways are Statin Pathway and Metabolism. GO annotations related to this gene include protein heterodimerization activity and lipid transporter activity.

UniProtKB/Swiss-Prot for MTTP Gene

  • Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).

Gene Wiki entry for MTTP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTTP Gene

Genomics for MTTP Gene

Regulatory Elements for MTTP Gene

Enhancers for MTTP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F099562 1.1 ENCODE 23.3 +0.3 266 3.4 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS SP3 MTTP LOC100507053 TRMT10A ADH5 ADH1B ADH1C
GH04F099571 1 ENCODE 20.7 +12.2 12178 9.0 ATF1 ARID4B DMAP1 YY1 FOS MXD4 MIER2 PPARG KAT8 SSRP1 MTTP TRMT10A LOC100507053 ADH1B ENSG00000248676
GH04F099561 1.1 Ensembl ENCODE 17.9 -2.5 -2461 0.6 ATF1 PKNOX1 CBX3 RAD21 CHAMP1 GTF3C2 POLR3A RCOR1 FOS CREM MTTP LOC100507053 C4orf17
GH04F099721 1.1 Ensembl ENCODE 14.2 +159.5 159516 2.6 ATF1 PKNOX1 RAD21 RFX5 YY1 GATA2 FOS CREM CEBPB REST MTTP TRMT10A DAPP1 ENSG00000248676
GH04F099845 1.4 FANTOM5 Ensembl ENCODE 10.6 +282.9 282873 3.3 HDGF MXI1 TBL1XR1 WRNIP1 CHD4 BMI1 RELA POLR2A EED ETV6 DAPP1 TRMT10A MTTP LAMTOR3 DNAJB14 ENSG00000279913
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTTP on UCSC Golden Path with GeneCards custom track

Promoters for MTTP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001246118 -61 2200 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS SP3

Genomic Location for MTTP Gene

Chromosome:
4
Start:
99,563,761 bp from pter
End:
99,623,999 bp from pter
Size:
60,239 bases
Orientation:
Plus strand

Genomic View for MTTP Gene

Genes around MTTP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTTP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTTP Gene

Proteins for MTTP Gene

  • Protein details for MTTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55157-MTP_HUMAN
    Recommended name:
    Microsomal triglyceride transfer protein large subunit
    Protein Accession:
    P55157
    Secondary Accessions:
    • A8K428
    • Q08AM4
    • Q6P5T3

    Protein attributes for MTTP Gene

    Size:
    894 amino acids
    Molecular mass:
    99351 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI) (PubMed:23475612, PubMed:26224785, PubMed:25108285). Interacts with APOB (PubMed:26224785, PubMed:25108285, PubMed:27206948).

    Alternative splice isoforms for MTTP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTTP Gene

Post-translational modifications for MTTP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTTP Gene

Domains & Families for MTTP Gene

Graphical View of Domain Structure for InterPro Entry

P55157

UniProtKB/Swiss-Prot:

MTP_HUMAN :
  • Contains 1 vitellogenin domain.
Domain:
  • Contains 1 vitellogenin domain.
genes like me logo Genes that share domains with MTTP: view

No data available for Gene Families for MTTP Gene

Function for MTTP Gene

Molecular function for MTTP Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).
UniProtKB/Swiss-Prot Induction:
Positively regulated by cholesterol and negatively regulated by insulin.

Gene Ontology (GO) - Molecular Function for MTTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity TAS --
GO:0005515 protein binding IPI 23475612
GO:0005548 phospholipid transporter activity IDA 23475612
GO:0008289 lipid binding IEA --
GO:0034185 apolipoprotein binding IEA --
genes like me logo Genes that share ontologies with MTTP: view
genes like me logo Genes that share phenotypes with MTTP: view

Human Phenotype Ontology for MTTP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MTTP Gene

MGI Knock Outs for MTTP:

Animal Model Products

miRNA for MTTP Gene

miRTarBase miRNAs that target MTTP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MTTP Gene

Localization for MTTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTTP Gene

Endoplasmic reticulum. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785). {ECO:0000269 PubMed:23475612, ECO:0000269 PubMed:26224785}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTTP gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
peroxisome 2
cytosol 2
plasma membrane 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MTTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 22236406
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with MTTP: view

Pathways & Interactions for MTTP Gene

genes like me logo Genes that share pathways with MTTP: view

Pathways by source for MTTP Gene

Gene Ontology (GO) - Biological Process for MTTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006497 protein lipidation IEA --
GO:0006629 lipid metabolic process TAS 1439810
GO:0006641 triglyceride metabolic process IEA --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with MTTP: view

No data available for SIGNOR curated interactions for MTTP Gene

Drugs & Compounds for MTTP Gene

(28) Drugs for MTTP Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lomitapide Approved Pharma Target, antagonist 0
Hesperetin Approved Pharma Target, antagonist 0
atorvastatin Approved Pharma Competitive, Inhibitor 0
Pravastatin Approved Pharma Competitive, Inhibitor 149
Implitapide Investigational Pharma inhibitor, Target 0

(28) Additional Compounds for MTTP Gene - From: Novoseek and HMDB