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Aliases for MTSS1L Gene

Aliases for MTSS1L Gene

  • Metastasis Suppressor 1-Like 2 3 5
  • Actin-Bundling With BAIAP2 Homology Protein 1 3 4
  • Actin-Bundling Protein With BAIAP2 Homology 2 3
  • ABBA-1 3 4

External Ids for MTSS1L Gene

Previous GeneCards Identifiers for MTSS1L Gene

  • GC16M069254
  • GC16M070695
  • GC16M056526

Summaries for MTSS1L Gene

GeneCards Summary for MTSS1L Gene

MTSS1L (Metastasis Suppressor 1-Like) is a Protein Coding gene. GO annotations related to this gene include actin binding and cytoskeletal adaptor activity. An important paralog of this gene is MTSS1.

UniProtKB/Swiss-Prot for MTSS1L Gene

  • May function in actin bundling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTSS1L Gene

Genomics for MTSS1L Gene

Regulatory Elements for MTSS1L Gene

Enhancers for MTSS1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTSS1L on UCSC Golden Path with GeneCards custom track

Promoters for MTSS1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTSS1L on UCSC Golden Path with GeneCards custom track

Genomic Location for MTSS1L Gene

70,661,204 bp from pter
70,686,066 bp from pter
24,863 bases
Minus strand

Genomic View for MTSS1L Gene

Genes around MTSS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTSS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTSS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTSS1L Gene

Proteins for MTSS1L Gene

  • Protein details for MTSS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MTSS1-like protein
    Protein Accession:
    Secondary Accessions:
    • A6NJI7
    • Q9BUA8

    Protein attributes for MTSS1L Gene

    747 amino acids
    Molecular mass:
    79929 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MTSS1L Gene


neXtProt entry for MTSS1L Gene

Proteomics data for MTSS1L Gene at MOPED

Post-translational modifications for MTSS1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTSS1L Gene

No data available for DME Specific Peptides for MTSS1L Gene

Domains & Families for MTSS1L Gene

Protein Domains for MTSS1L Gene


Suggested Antigen Peptide Sequences for MTSS1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IMD (IRSp53/MIM homology) domain.
  • Belongs to the MTSS1 family.
  • Contains 1 IMD (IRSp53/MIM homology) domain.
  • Contains 1 WH2 domain.
  • Belongs to the MTSS1 family.
genes like me logo Genes that share domains with MTSS1L: view

No data available for Gene Families for MTSS1L Gene

Function for MTSS1L Gene

Molecular function for MTSS1L Gene

UniProtKB/Swiss-Prot Function:
May function in actin bundling.

Phenotypes for MTSS1L Gene

genes like me logo Genes that share phenotypes with MTSS1L: view

Animal Models for MTSS1L Gene

MGI Knock Outs for MTSS1L:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTSS1L Gene

Localization for MTSS1L Gene

Subcellular locations from

Jensen Localization Image for MTSS1L Gene COMPARTMENTS Subcellular localization image for MTSS1L gene
Compartment Confidence
cytosol 4
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MTSS1L Gene

Pathways & Interactions for MTSS1L Gene

SuperPathways for MTSS1L Gene

No Data Available

Interacting Proteins for MTSS1L Gene

Gene Ontology (GO) - Biological Process for MTSS1L Gene


No data available for Pathways by source and SIGNOR curated interactions for MTSS1L Gene

Drugs & Compounds for MTSS1L Gene

No Compound Related Data Available

Transcripts for MTSS1L Gene

Unigene Clusters for MTSS1L Gene

Metastasis suppressor 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTSS1L Gene

No ASD Table

Relevant External Links for MTSS1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTSS1L Gene

mRNA expression in normal human tissues for MTSS1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTSS1L Gene

This gene is overexpressed in Brain (35.0) and Frontal cortex (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTSS1L Gene

SOURCE GeneReport for Unigene cluster for MTSS1L Gene Hs.432387

genes like me logo Genes that share expression patterns with MTSS1L: view

Protein tissue co-expression partners for MTSS1L Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTSS1L Gene

Orthologs for MTSS1L Gene

This gene was present in the common ancestor of animals.

Orthologs for MTSS1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MTSS1L 35
  • 91.47 (n)
  • 93.99 (a)
  • 90 (a)
(Canis familiaris)
Mammalia MTSS1L 35
  • 91.35 (n)
  • 94.17 (a)
  • 93 (a)
(Mus musculus)
Mammalia Mtss1l 35
  • 89.25 (n)
  • 95.92 (a)
Mtss1l 16
Mtss1l 36
  • 95 (a)
(Pan troglodytes)
Mammalia MTSS1L 35
  • 99.17 (n)
  • 99.86 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mtss1l 35
  • 89.53 (n)
  • 96.34 (a)
(Monodelphis domestica)
Mammalia MTSS1L 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia MTSS1L 36
  • 84 (a)
(Gallus gallus)
Aves MTSS1L 35
  • 81.83 (n)
  • 85.45 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia MTSS1L 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtss1l 35
  • 70.83 (n)
  • 77.64 (a)
Str.17843 35
(Danio rerio)
Actinopterygii mtss1l 35
  • 68.55 (n)
  • 73.37 (a)
mtss1l 36
  • 60 (a)
MTSS1L (2 of 2) 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta mim 36
  • 5 (a)
(Caenorhabditis elegans)
Secernentea M04F3.5 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
-- 36
  • 21 (a)
Species with no ortholog for MTSS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTSS1L Gene

Gene Tree for MTSS1L (if available)
Gene Tree for MTSS1L (if available)

Paralogs for MTSS1L Gene

Paralogs for MTSS1L Gene

(1) SIMAP similar genes for MTSS1L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MTSS1L: view

Variants for MTSS1L Gene

Sequence variations from dbSNP and Humsavar for MTSS1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs12934558 -- 70,678,497(+) GGCAT(A/C)TCTCG intron-variant
rs12934681 -- 70,678,499(+) CATCT(C/T)TCGGC intron-variant
rs13334862 -- 70,665,782(+) GCATT(G/T)TGAAG intron-variant
rs60964009 -- 70,684,112(+) TTCCA(C/T)GAGCA intron-variant
rs61095688 -- 70,677,047(+) CCCCC(C/G)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTSS1L Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv517391 CNV Loss 19592680
dgv2904n71 CNV Loss 21882294
dgv2905n71 CNV Loss 21882294
nsv906881 CNV Loss 21882294
dgv2906n71 CNV Loss 21882294
nsv906883 CNV Loss 21882294
nsv471094 CNV Loss 18288195
nsv906885 CNV Loss 21882294
nsv1856 CNV Insertion 18451855
dgv2907n71 CNV Loss 21882294
nsv906888 CNV Loss 21882294
esv2666396 CNV Deletion 23128226

Variation tolerance for MTSS1L Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTSS1L Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTSS1L Gene

Disorders for MTSS1L Gene

Relevant External Links for MTSS1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MTSS1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTSS1L Gene

Publications for MTSS1L Gene

  1. A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. (PMID: 14752106) Yamagishi A. … Mochizuki N. (J. Biol. Chem. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  5. The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators. (PMID: 25669885) Di Fiore B. … Pines J. (Dev. Cell 2015) 3

Products for MTSS1L Gene

Sources for MTSS1L Gene