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Aliases for MTSS1L Gene

Aliases for MTSS1L Gene

  • Metastasis Suppressor 1-Like 2 3
  • Actin-Bundling With BAIAP2 Homology Protein 1 3 4
  • Actin-Bundling Protein With BAIAP2 Homology 2 3
  • ABBA-1 3 4
  • MTSS1-Like Protein 3

External Ids for MTSS1L Gene

Summaries for MTSS1L Gene

GeneCards Summary for MTSS1L Gene

MTSS1L (Metastasis Suppressor 1-Like) is a Protein Coding gene. GO annotations related to this gene include actin binding and cytoskeletal adaptor activity. An important paralog of this gene is MTSS1.

UniProtKB/Swiss-Prot for MTSS1L Gene

  • May function in actin bundling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTSS1L Gene

Genomics for MTSS1L Gene

Genomic Location for MTSS1L Gene

Start:
70,661,204 bp from pter
End:
70,686,066 bp from pter
Size:
24,863 bases
Orientation:
Minus strand

Genomic View for MTSS1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTSS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTSS1L Gene

Regulatory Elements for MTSS1L Gene

Proteins for MTSS1L Gene

  • Protein details for MTSS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q765P7-MTSSL_HUMAN
    Recommended name:
    MTSS1-like protein
    Protein Accession:
    Q765P7
    Secondary Accessions:
    • A6NJI7
    • Q9BUA8

    Protein attributes for MTSS1L Gene

    Size:
    747 amino acids
    Molecular mass:
    79929 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MTSS1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTSS1L Gene

Proteomics data for MTSS1L Gene at MOPED

Post-translational modifications for MTSS1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTSS1L Gene

No data available for DME Specific Peptides for MTSS1L Gene

Domains for MTSS1L Gene

Protein Domains for MTSS1L Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MTSSL_HUMAN
Domain:
  • Contains 1 IMD (IRSp53/MIM homology) domain.:
    • Q765P7
  • Contains 1 WH2 domain.:
    • Q765P7
Family:
  • Belongs to the MTSS1 family.:
    • Q765P7
genes like me logo Genes that share domains with MTSS1L: view

No data available for Gene Families for MTSS1L Gene

Function for MTSS1L Gene

Molecular function for MTSS1L Gene

UniProtKB/Swiss-Prot Function: May function in actin bundling.

Gene Ontology (GO) - Molecular Function for MTSS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0008093 cytoskeletal adaptor activity --
GO:0017124 SH3 domain binding --
genes like me logo Genes that share ontologies with MTSS1L: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTSS1L Gene

Localization for MTSS1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTSS1L Gene COMPARTMENTS Subcellular localization image for MTSS1L gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for MTSS1L Gene

Pathways for MTSS1L Gene

SuperPathways for MTSS1L Gene

No Data Available

Interacting Proteins for MTSS1L Gene

Gene Ontology (GO) - Biological Process for MTSS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IEA --
GO:0007165 signal transduction --
GO:0046847 filopodium assembly --
GO:0097178 ruffle assembly IEA --
genes like me logo Genes that share ontologies with MTSS1L: view

No data available for Pathways by source for MTSS1L Gene

Transcripts for MTSS1L Gene

Unigene Clusters for MTSS1L Gene

Metastasis suppressor 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTSS1L Gene

No ASD Table

Relevant External Links for MTSS1L Gene

GeneLoc Exon Structure for
MTSS1L
ECgene alternative splicing isoforms for
MTSS1L

Expression for MTSS1L Gene

mRNA expression in normal human tissues for MTSS1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MTSS1L Gene

SOURCE GeneReport for Unigene cluster for MTSS1L Gene Hs.432387

genes like me logo Genes that share expressions with MTSS1L: view

Orthologs for MTSS1L Gene

This gene was present in the common ancestor of animals.

Orthologs for MTSS1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTSS1L 36
  • 99.17 (n)
  • 99.86 (a)
MTSS1L 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTSS1L 36
  • 91.47 (n)
  • 93.99 (a)
MTSS1L 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTSS1L 36
  • 91.35 (n)
  • 94.17 (a)
MTSS1L 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtss1l 36
  • 89.25 (n)
  • 95.92 (a)
Mtss1l 16
Mtss1l 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTSS1L 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTSS1L 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtss1l 36
  • 89.53 (n)
  • 96.34 (a)
chicken
(Gallus gallus)
Aves MTSS1L 36
  • 81.83 (n)
  • 85.45 (a)
MTSS1L 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTSS1L 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtss1l 36
  • 70.83 (n)
  • 77.64 (a)
Str.17843 36
zebrafish
(Danio rerio)
Actinopterygii mtss1l 36
  • 68.55 (n)
  • 73.37 (a)
mtss1l 37
  • 60 (a)
OneToMany
MTSS1L (2 of 2) 37
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mim 37
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M04F3.5 37
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
Species with no ortholog for MTSS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTSS1L Gene

ENSEMBL:
Gene Tree for MTSS1L (if available)
TreeFam:
Gene Tree for MTSS1L (if available)

Paralogs for MTSS1L Gene

Paralogs for MTSS1L Gene

Selected SIMAP similar genes for MTSS1L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MTSS1L: view

Variants for MTSS1L Gene

Sequence variations from dbSNP and Humsavar for MTSS1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1979256 -- 70,675,728(+) TCATT(C/T)CTAAA intron-variant
rs2054183 -- 70,666,460(+) GTGAC(C/G)GGCAG intron-variant
rs2124832 -- 70,669,714(+) cggga(A/G)gctga intron-variant
rs2864755 -- 70,666,809(+) CAAGC(C/T)GCTAG intron-variant
rs3058050 -- 70,669,828(+) AAAAA(-/A/AAA/AAAA/AAAAAA)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTSS1L Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv517391 CNV Loss 19592680
dgv2904n71 CNV Loss 21882294
dgv2905n71 CNV Loss 21882294
nsv906881 CNV Loss 21882294
dgv2906n71 CNV Loss 21882294
nsv906883 CNV Loss 21882294
nsv471094 CNV Loss 18288195
nsv906885 CNV Loss 21882294
nsv1856 CNV Insertion 18451855
dgv2907n71 CNV Loss 21882294
nsv906888 CNV Loss 21882294
esv2666396 CNV Deletion 23128226

Relevant External Links for MTSS1L Gene

HapMap Linkage Disequilibrium report
MTSS1L
Human Gene Mutation Database (HGMD)
MTSS1L

Disorders for MTSS1L Gene

No disorders were found for MTSS1L Gene.

No data available for UniProtKB/Swiss-Prot for MTSS1L Gene

Publications for MTSS1L Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. (PMID: 14752106) Yamagishi A. … Mochizuki N. (J. Biol. Chem. 2004) 3 4
  3. Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1. (PMID: 20875796) Zheng D. … Zhan X. (Biochem. Biophys. Res. Commun. 2010) 3
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  5. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3

Products for MTSS1L Gene

Sources for MTSS1L Gene

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