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Aliases for MTSS1 Gene

Aliases for MTSS1 Gene

  • Metastasis Suppressor 1 2 3
  • MIM 3 4 6
  • Missing In Metastasis Protein 3 4
  • Metastasis Suppressor YGL-1 3 4
  • KIAA0429 4 6
  • Metastasis Suppressor Protein 1 3
  • MIMA 3
  • MIMB 3

External Ids for MTSS1 Gene

Previous GeneCards Identifiers for MTSS1 Gene

  • GC08M125567
  • GC08M125231
  • GC08M125519
  • GC08M125632
  • GC08M125563
  • GC08M120888

Summaries for MTSS1 Gene

GeneCards Summary for MTSS1 Gene

MTSS1 (Metastasis Suppressor 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Hedgehog signaling events mediated by Gli proteins. GO annotations related to this gene include identical protein binding and SH3 domain binding. An important paralog of this gene is MTSS1L.

UniProtKB/Swiss-Prot for MTSS1 Gene

  • May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton

Gene Wiki entry for MTSS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTSS1 Gene

Genomics for MTSS1 Gene

Regulatory Elements for MTSS1 Gene

Genomic Location for MTSS1 Gene

124,550,770 bp from pter
124,728,507 bp from pter
177,738 bases
Minus strand

Genomic View for MTSS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTSS1 Gene

Proteins for MTSS1 Gene

  • Protein details for MTSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metastasis suppressor protein 1
    Protein Accession:
    Secondary Accessions:
    • J3KNK6
    • Q8TCA2
    • Q96RX2

    Protein attributes for MTSS1 Gene

    755 amino acids
    Molecular mass:
    82251 Da
    Quaternary structure:
    • Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta.

    Three dimensional structures from OCA and Proteopedia for MTSS1 Gene

    Alternative splice isoforms for MTSS1 Gene


neXtProt entry for MTSS1 Gene

Proteomics data for MTSS1 Gene at MOPED

Post-translational modifications for MTSS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTSS1 Gene

Domains for MTSS1 Gene

Protein Domains for MTSS1 Gene


Graphical View of Domain Structure for InterPro Entry



  • O43312
  • The WH2 motif at the C-terminus binds to actin monomers
  • Contains 1 IMD (IRSp53/MIM homology) domain.
  • Contains 1 WH2 domain.
  • Belongs to the MTSS1 family.
genes like me logo Genes that share domains with MTSS1: view

No data available for Gene Families for MTSS1 Gene

Function for MTSS1 Gene

Molecular function for MTSS1 Gene

UniProtKB/Swiss-Prot Function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton

Gene Ontology (GO) - Molecular Function for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0003785 actin monomer binding IDA 12570871
GO:0005102 receptor binding IPI 12570871
GO:0005515 protein binding IPI 15383276
GO:0008093 cytoskeletal adaptor activity --
genes like me logo Genes that share ontologies with MTSS1: view
genes like me logo Genes that share phenotypes with MTSS1: view

Animal Models for MTSS1 Gene

MGI Knock Outs for MTSS1:

miRNA for MTSS1 Gene

miRTarBase miRNAs that target MTSS1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MTSS1 Gene

Localization for MTSS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTSS1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for MTSS1 Gene COMPARTMENTS Subcellular localization image for MTSS1 gene
Compartment Confidence
cytoskeleton 5
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle NAS 12570871
GO:0005737 cytoplasm TAS 12570871
GO:0005912 adherens junction IEA --
GO:0015629 actin cytoskeleton IDA 12570871
GO:0030139 endocytic vesicle TAS 12570871
genes like me logo Genes that share ontologies with MTSS1: view

Pathways for MTSS1 Gene

genes like me logo Genes that share pathways with MTSS1: view

Pathways by source for MTSS1 Gene

1 Cell Signaling Technology pathway for MTSS1 Gene
1 BioSystems pathway for MTSS1 Gene

Gene Ontology (GO) - Biological Process for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006928 movement of cell or subcellular component NAS 12570871
GO:0007009 plasma membrane organization IEA --
GO:0007015 actin filament organization --
genes like me logo Genes that share ontologies with MTSS1: view

Transcripts for MTSS1 Gene

mRNA/cDNA for MTSS1 Gene

Unigene Clusters for MTSS1 Gene

Metastasis suppressor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTSS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8: -

ExUns: 19a · 19b

Relevant External Links for MTSS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTSS1 Gene

mRNA expression in normal human tissues for MTSS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MTSS1 Gene

SOURCE GeneReport for Unigene cluster for MTSS1 Gene Hs.336994

mRNA Expression by UniProt/SwissProt for MTSS1 Gene

Tissue specificity: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
genes like me logo Genes that share expressions with MTSS1: view

No data available for mRNA differential expression in normal tissues for MTSS1 Gene

Orthologs for MTSS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTSS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTSS1 35
  • 99.65 (n)
  • 99.74 (a)
MTSS1 36
  • 100 (a)
(Bos Taurus)
Mammalia MTSS1 35
  • 90.73 (n)
  • 96.69 (a)
MTSS1 36
  • 97 (a)
(Canis familiaris)
Mammalia MTSS1 35
  • 92.18 (n)
  • 97.36 (a)
MTSS1 36
  • 92 (a)
(Mus musculus)
Mammalia Mtss1 35
  • 89.99 (n)
  • 96.57 (a)
Mtss1 16
Mtss1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia MTSS1 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia MTSS1 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Mtss1 35
  • 90.25 (n)
  • 95.65 (a)
(Gallus gallus)
Aves MTSS1 35
  • 80.31 (n)
  • 87.87 (a)
MTSS1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia MTSS1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtss1.1 35
  • 75.29 (n)
  • 83.02 (a)
(Danio rerio)
Actinopterygii si:dkey-46l15.1 35
  • 63.71 (n)
  • 64.96 (a)
si:dkey-46l15.1 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta mim 36
  • 5 (a)
(Caenorhabditis elegans)
Secernentea M04F3.5 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
-- 36
  • 21 (a)
Species with no ortholog for MTSS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTSS1 Gene

Gene Tree for MTSS1 (if available)
Gene Tree for MTSS1 (if available)

Paralogs for MTSS1 Gene

Paralogs for MTSS1 Gene

Selected SIMAP similar genes for MTSS1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with MTSS1: view

Variants for MTSS1 Gene

Sequence variations from dbSNP and Humsavar for MTSS1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1647 -- 124,685,169(+) AGAAC(C/T)TTTTC intron-variant
rs729513 -- 124,720,778(+) AAAAT(A/T)CCTCA intron-variant
rs748020 -- 124,603,425(-) AAAGA(A/G)CAAGG intron-variant
rs752492 -- 124,603,497(+) CAAAG(C/T)CAGCA intron-variant
rs874293 -- 124,729,157(-) AAAAC(C/G)ATCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTSS1 Gene

Variant ID Type Subtype PubMed ID
nsv465801 CNV Loss 19166990
nsv525649 CNV Gain 19592680
nsv465802 CNV Loss 19166990
nsv528287 CNV Gain 19592680
esv275001 CNV Gain+Loss 21479260
esv5049 CNV Deletion 18987735
nsv396843 CNV Insertion 16902084
esv23776 CNV Gain 19812545
nsv891434 CNV Gain 21882294
esv275526 CNV Loss 21479260
esv2737533 CNV Deletion 23290073
nsv507489 CNV Insertion 20534489
esv2737534 CNV Deletion 23290073
esv2737535 CNV Deletion 23290073

Relevant External Links for MTSS1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTSS1 Gene

Disorders for MTSS1 Gene

(5) Novoseek inferred disease relationships for MTSS1 Gene

Disease -log(P) Hits PubMed IDs
bladder cancer metastatic 88 2
wiskott-aldrich syndrome 75.1 2
metastasis 41.4 10
cancer 11.3 3
tumors 0 1

Relevant External Links for MTSS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MTSS1: view

No data available for UniProtKB/Swiss-Prot for MTSS1 Gene

Publications for MTSS1 Gene

  1. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. (PMID: 12482861) Mattila P.K. … Lappalainen P. (J. Biol. Chem. 2003) 2 3 23
  2. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. (PMID: 12570871) Woodings J.A. … Machesky L.M. (Biochem. J. 2003) 3 4 23
  3. MIM, a potential metastasis suppressor gene in bladder cancer. (PMID: 12082544) Lee Y.-G. … Pienta K.J. (Neoplasia 2002) 2 3 4
  4. Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. (PMID: 16280553) Bompard G. … Machesky L.M. (J. Cell. Sci. 2005) 3 23
  5. Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. (PMID: 15488640) Nixdorf S. … Jackson P. (Cancer Lett. 2004) 3 23

Products for MTSS1 Gene

Sources for MTSS1 Gene

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