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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTSS1 Gene

protein-coding   GIFtS: 60
GCID: GC08M125563

Metastasis Suppressor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Metastasis Suppressor 11 2     KIAA04293 5
MIM2 3 5     MIMA2
Metastasis Suppressor YGL-12 3     MIMB2
Missing In Metastasis Protein2 3     Metastasis Suppressor Protein 12

External Ids:    HGNC: 204431   Entrez Gene: 97882   Ensembl: ENSG000001708737   OMIM: 6084865   UniProtKB: O433123   

Export aliases for MTSS1 gene to outside databases

Previous GC identifers: GC08M125567 GC08M125231 GC08M125519 GC08M125632 GC08M120888


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MTSS1 Gene: 
MTSS1 (metastasis suppressor 1) is a protein-coding gene. Diseases associated with MTSS1 include wiskott-aldrich syndrome, and kidney cancer. GO annotations related to this gene include SH3 domain binding and identical protein binding. An important paralog of this gene is MTSS1L.

UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
Function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely
through an interaction with the actin cytoskeleton

Gene Wiki entry for MTSS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTSS1 gene promoter:
         AhR   MyoD   RORalpha2   C/EBPalpha   AREB6   PPAR-gamma1   S8   c-Myb   PPAR-gamma2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MTSS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTSS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTSS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8p22

MTSS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTSS1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M125563:  view genomic region     (about GC identifiers)

Start:
125,563,025 bp from pter      End:
125,740,730 bp from pter
Size:
177,706 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312 (See protein sequence)
Recommended Name: Metastasis suppressor protein 1  
Size: 755 amino acids; 82251 Da
Subunit: Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta
Subcellular location: Cytoplasm, cytoskeleton
1 PDB 3D structure from and Proteopedia for MTSS1:
2D1K (3D)    
Secondary accessions: Q8TCA2 Q96RX2
Alternative splicing: 3 isoforms:  O43312-1   O43312-2   O43312-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTSS1: NX_O43312

Explore proteomics data for MTSS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43312

  • MTSS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTSS1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269900.1  NP_001269903.1  NP_055566.3  

    ENSEMBL proteins: 
     ENSP00000367256   ENSP00000429064   ENSP00000428685   ENSP00000322804   ENSP00000393606  
     ENSP00000428319   ENSP00000428348   ENSP00000428145   ENSP00000429752   ENSP00000346119  
     ENSP00000378884  

    Human Recombinant Protein Products for MTSS1: 
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    Novus Biologicals MTSS1 Protein
    Sino Biological Recombinant Protein for MTSS1
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTSS1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle NAS12570871
    GO:0005737cytoplasm TAS12570871
    GO:0015629actin cytoskeleton IDA12570871
    GO:0030139endocytic vesicle TAS12570871

    MTSS1 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for MTSS1 

    Assay Products for MTSS1: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for MTSS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR013606 IRSp53/MIM_homology_IMD
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry O43312

    ProtoNet protein and cluster: O43312

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
    Domain: The WH2 motif at the C-terminus binds to actin monomers
    Similarity: Belongs to the MTSS1 family
    Similarity: Contains 1 IMD (IRSp53/MIM homology) domain
    Similarity: Contains 1 WH2 domain


    MTSS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTSS1_HUMAN, O43312
    Function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely
    through an interaction with the actin cytoskeleton

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ----
    GO:0003785actin monomer binding IDA12570871
    GO:0005102receptor binding IPI12570871
    GO:0005515protein binding IPI15383276
    GO:0008093cytoskeletal adaptor activity IEA--
         
    MTSS1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mtss1):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  renal/urinary system  skeleton  tumorigenesis 

    MTSS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mtss1tm1Pla for MTSS1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MTSS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MTSS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTSS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTSS1 

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    hsa-miR-596 hsa-miR-200a hsa-miR-141 hsa-miR-654-5p hsa-miR-532-5p hsa-miR-23a hsa-miR-28-5p hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidMTSS1 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of MTSS1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTSS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MTSS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hedgehog signaling events mediated by Gli proteins
    Hedgehog signaling events mediated by Gli proteins
    2Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MTSS1
        Cytoskeletal Signaling

    1 BioSystems Pathway for MTSS1
        Hedgehog signaling events mediated by Gli proteins




    MTSS1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTSS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for MTSS1 (O433121, 2, 3 ENSP000003228044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-473954,EBI-466029 MINT-3978180 MINT-3978484 MINT-3978605 I2D: score=3 STRING: ENSP00000347184
    CTTNQ142472, 3, ENSP000003018434MINT-7306884 I2D: score=2 STRING: ENSP00000301843
    PTPRDP234683, ENSP000003488124I2D: score=1 STRING: ENSP00000348812
    RECQL5O947623I2D: score=4 
    ACTA1P681333I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement NAS12570871
    GO:0007015actin filament organization ----
    GO:0007155cell adhesion NAS12570871
    GO:0007165signal transduction ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS12570871

    MTSS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTSS1

    Search CenterWatch for drugs/clinical trials and news about MTSS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTSS1 gene (3 alternative transcripts): 
    NM_001282971.1  NM_001282974.1  NM_014751.5  

    Unigene Cluster for MTSS1:

    Metastasis suppressor 1
    Hs.336994  [show with all ESTs]
    Unigene Representative Sequence: NM_014751
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000378017(uc003yri.2) ENST00000518547(uc011lin.1 uc011lio.1 uc003yrk.2 uc003yrl.2)
    ENST00000520771(uc003yrh.2) ENST00000519168 ENST00000325064 ENST00000431961
    ENST00000523587 ENST00000524090 ENST00000523179 ENST00000520094 ENST00000522722
    ENST00000522118 ENST00000519226 ENST00000522162 ENST00000529463 ENST00000519671
    ENST00000524243 ENST00000472084
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTSS1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MTSS1 (see all 45):
    hsa-miR-596 hsa-miR-200a hsa-miR-141 hsa-miR-654-5p hsa-miR-532-5p hsa-miR-23a hsa-miR-28-5p hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidMTSS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MTSS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTSS1
    Clone
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    GenScript: all cDNA clones in your preferred vector: MTSS1 (NM_014751)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTSS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTSS1
    Sirion Biotech Customized lentivirus for stable overexpression of MTSS1 
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTSS1

    Additional mRNA sequence: 

    AB007889.2 AF086645.1 AF116674.1 AK027015.1 AK126651.1 AK126989.1 AK295681.1 AK302036.1 
    AK310792.1 BC023998.1 EF560715.1 U50573.1 

    14 DOTS entries:

    DT.454840  DT.95137631  DT.95244731  DT.100752014  DT.99959639  DT.97844620  DT.91654072  DT.121486184 
    DT.121486474  DT.92429725  DT.121486151  DT.100657894  DT.100752013  DT.86853309 

    9 AceView cDNA sequences:

    BF508649 BM675543 BU535618 BX492881 BM931744 AW976253 BG913875 AI554562 
    BF674886 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MTSS1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^
    SP1:                          -     -     -                                                     -     -           -                                             
    SP2:                                                                                            -     -                 -                                       
    SP3:                                                                                            -     -           -     -     -                                 
    SP4:                                                                                            -     -           -     -                                       
    SP5:                                                                                            -     -           -                                             

    ExUns: 19a · 19b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MTSS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTSS1 expression in normal human tissues (normalized intensities)      MTSS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATTAGAA
    MTSS1 Expression
    About this image


    MTSS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem progenitor F15
     
     Ovary (Reproductive System)
             Human Ovarian Fibroblasts (HOF)   
     
     Endothelium (Cardiovascular System)
             PureStem endothelial progenitor RP1-MV2-18
     
     Fibroblast (Uncategorized)
             Human Ovarian Fibroblasts (HOF)   
     
     Brain (Nervous System)
             brain/hindbrain   

    See MTSS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTSS1

    SOURCE GeneReport for Unigene cluster: Hs.336994

    UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
    Tissue specificity: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and
    peripheral blood

        SABiosciences Expression via Pathway-Focused PCR Arrays including MTSS1: 
              Notch Signaling Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTSS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MTSS1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtss11 , 5 metastasis suppressor 11, 5 86.53(n)1
    93.29(a)1
      15 (25.09 cM)5
    2114011  NM_001146180.11  NP_001139652.11 
     589412445 
    chicken
    (Gallus gallus)
    Aves MTSS11 metastasis suppressor 1 80.31(n)
    87.87(a)
      420336  NM_001030954.1  NP_001026125.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTSS16
    metastasis suppressor 1
    77(a)
    1 ↔ 1
    4(6082134-6251587)
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    46(a)
    possible ortholog
    6(50532243-50637165)
    fruit fly
    (Drosophila melanogaster)
    Insecta mim6
    missing-in-metastasis
    9(a)
    1 → many
    2R(2812192-2859142)
    worm
    (Caenorhabditis elegans)
    Secernentea M04F3.56
    Protein M04F3.5
    14(a)
    1 → many
    I(4773818-4777717)


    ENSEMBL Gene Tree for MTSS1 (if available)
    TreeFam Gene Tree for MTSS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTSS1 gene
    MTSS1L2  
    1 SIMAP similar gene for MTSS1 using alignment to 9 protein entries:     MTSS1_HUMAN (see all proteins):
    MTSS1L

    MTSS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4139 SNPs in MTSS1 are shown (see all 4139)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681100141,2
    C--120917847(+) TTTTT-/ATTTTTT 1 -- int11Minor allele frequency- AT:0.00NA 2
    rs779020621,2
    C,F--125562745(+) AAGGTA/GAGGGA 1 -- ds50013Minor allele frequency- G:0.34CSA WA 122
    rs1859548321,2
    --125562846(+) TTTAGC/TTCTTG 1 -- ds50010--------
    rs1910466811,2
    --125562906(+) TCTTAC/TAGCCA 1 -- ds50010--------
    rs123353141,2
    C,F,H--125563025(+) AGGACT/GTTTTT 1 -- ut317Minor allele frequency- G:0.04NS EA CSA WA 534
    rs751455981,2
    F--125563094(+) AGACAC/TATTAC 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1815340981,2
    --125563125(+) TTTAGA/GACAAA 1 -- ut310--------
    rs1154934861,2
    C,F--125563159(+) TCTCAG/CTACAA 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs1858781021,2
    --125563168(+) AAACTA/GGCAAC 1 -- ut310--------
    rs1912259601,2
    --125563362(+) GCTGTA/GCCAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MTSS1 (125563025 - 125740730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for MTSS1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737533CNV Deletion23290073
    esv2737534CNV Deletion23290073
    esv5049CNV Deletion18987735
    esv2737535CNV Deletion23290073
    nsv507489CNV Insertion20534489
    nsv396843CNV Insertion16902084
    nsv465801CNV Loss19166990
    nsv465802CNV Loss19166990
    esv275526CNV Loss21479260
    nsv891434CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing MTSS1:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing MTSS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MTSS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608486    OMIM disorders: --

    7 diseases for MTSS1:    About MalaCards
    wiskott-aldrich syndrome    kidney cancer    hepatocellular carcinoma    squamous cell carcinoma
    prostate cancer    prostatitis    breast cancer


    MTSS1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for MTSS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer metastatic 88 4 15870888 (1), 12482861 (1)
    wiskott-aldrich syndrome 75.1 2 15870888 (1), 12570871 (1)
    metastasis 41.4 17 12570871 (3), 16280553 (2), 15870888 (2), 15488640 (2) (see all 5)
    cancer 11.3 3 16280553 (1), 15870888 (1), 12570871 (1)
    tumors 0 1 15870888 (1)

    Genetic Association Database (GAD): MTSS1
    Human Genome Epidemiology (HuGE) Navigator: MTSS1 (3 documents)

    Export disorders for MTSS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTSS1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with MTSS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MIM, a potential metastasis suppressor gene in bladder cancer. (PubMed id 12082544)1, 2, 3 Lee Y.G....Pienta K.J. (2002)
    2. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. (PubMed id 12482861)1, 3, 9 Mattila P.K....Lappalainen P. (2003)
    3. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. (PubMed id 12570871)1, 2, 9 Woodings J.A.... Machesky L.M. (2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (2010)
    6. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    10. Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. (PubMed id 15488640)1, 9 Nixdorf S....Jackson P. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9788 HGNC: 20443 AceView: MTSS1.1 Ensembl:ENSG00000170873 euGenes: HUgn9788
    ECgene: MTSS1 H-InvDB: MTSS1

    (According to HUGE)
    About This Section
    HUGE: KIAA0429

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTSS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTSS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTSS1 gene:
    Search GeneIP for patents involving MTSS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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