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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTSS1 Gene

protein-coding   GIFtS: 57
GCID: GC08M125563

metastasis suppressor 1
 Explore 9 diseases affiliated with
MTSS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MTSS1    

Aliases
for MTSS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metastasis Suppressor 11 2     MIMB1 2
MIM1 2 3 5     Metastasis Suppressor YGL-12 3
KIAA04291 3 5     Missing In Metastasis Protein2 3
MIMA1 2     Metastasis Suppressor Protein 12

External Ids:    HGNC: 204431   Entrez Gene: 97882   Ensembl: ENSG000001708737   OMIM: 6084865   UniProtKB: O433123   

Export aliases for MTSS1 gene to outside databases

Previous GC identifers: GC08M125567 GC08M125231 GC08M125519 GC08M125632 GC08M120888


Summaries
for MTSS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
Function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an
interaction with the actin cytoskeleton

Gene Wiki entry for MTSS1


Genomic Views
for MTSS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTSS1 gene promoter:
         AhR   MyoD   RORalpha2   C/EBPalpha   AREB6   PPAR-gamma1   S8   c-Myb   PPAR-gamma2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MTSS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTSS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTSS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8p22

MTSS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTSS1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M125563:  view genomic region     (about GC identifiers)

Start:
 125,563,025 bp from pter      End:
 125,740,730 bp from pter
Size:
 177,706 bases      Orientation:
 minus strand

Proteins
for MTSS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312 (See protein sequence)
Recommended Name: Metastasis suppressor protein 1  
Size: 755 amino acids; 82251 Da
Subunit: Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta
Subcellular location: Cytoplasm, cytoskeleton
1 PDB 3D structure from and Proteopedia for MTSS1:
2D1K (3D)    
Secondary accessions: Q8TCA2 Q96RX2
Alternative splicing: 3 isoforms:  O43312-1   O43312-2   O43312-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTSS1: NX_O43312

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43312

    • MTSS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055566.3  
    ENSEMBL proteins: 
     ENSP00000367256   ENSP00000429064   ENSP00000428685   ENSP00000322804   ENSP00000393606  
     ENSP00000428319   ENSP00000428348   ENSP00000428145   ENSP00000429752   ENSP00000346119  
     ENSP00000378884  

    Human Recombinant Protein Products: 
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    Novus Biologicals MTSS1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MTSS1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle NAS12570871
    GO:0005737cytoplasm TAS12570871
    GO:0015629actin cytoskeleton IDA12570871
    GO:0030139endocytic vesicle TAS12570871


    MTSS1 for ontologies           About GeneDecksing



    MTSS1 Antibody Products: 
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    Assay Products for MTSS1: 
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    Uscn ELISAs and CLIAs for MTSS1

    Protein Domains /
    Families
    for MTSS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MTSS1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003124 WH2_dom
     IPR013606 IRSp53/MIM_homology_IMD

    Graphical View of Domain Structure for InterPro Entry O43312

    ProtoNet protein and cluster: O43312

    1 Blocks protein family: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
    Domain: The WH2 motif at the C-terminus binds to actin monomers
    Similarity: Belongs to the MTSS1 family
    Similarity: Contains 1 IMD (IRSp53/MIM homology) domain
    Similarity: Contains 1 WH2 domain


    Function
    for MTSS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
    Function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an
    interaction with the actin cytoskeleton

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTSS1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MTSS1 (see all 45):
    hsa-miR-596 hsa-miR-200a hsa-miR-141 hsa-miR-654-5p hsa-miR-532-5p hsa-miR-23a hsa-miR-28-5p hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmid: MTSS1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTSS1 (see all 6)
    OriGene siRNA: MTSS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTSS1

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MTSS1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTSS1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ----
    GO:0003785actin monomer binding IDA12570871
    GO:0005102receptor binding IPI12570871
    GO:0005515protein binding IPI15383276
    GO:0008093cytoskeletal adaptor activity IEA--


    MTSS1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Mtss1tm1Pla for MTSS1
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mtss1):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  renal/urinary system  skeleton  tumorigenesis 

    MTSS1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MTSS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Hedgehog signaling events mediated by Gli proteins
    		Hedgehog signaling events mediated by Gli proteins1.00
    2Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MTSS1
        Cytoskeletal Signaling

    1 BioSystems Pathway for MTSS1 
        Hedgehog signaling events mediated by Gli proteins



    MTSS1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTSS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for MTSS1 (O433121, 2, 3 ENSP000003228044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-473954,EBI-466029 MINT-3978180 MINT-3978484 MINT-3978605 I2D: score=3 STRING: ENSP00000347184
    CTTNQ142472, 3, ENSP000003018434MINT-7306884 I2D: score=2 STRING: ENSP00000301843
    PTPRDP234683, ENSP000003488124I2D: score=1 STRING: ENSP00000348812
    RECQL5O947623I2D: score=4 
    ACTA1P681333I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement NAS12570871
    GO:0007015actin filament organization ----
    GO:0007155cell adhesion NAS12570871
    GO:0007165signal transduction ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS12570871


    MTSS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MTSS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTSS1
    Search CenterWatch for drugs/clinical trials and news about MTSS1 

    Transcripts
    for MTSS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MTSS1 gene: 
    NM_014751.4  

    Unigene Cluster for MTSS1:

    Metastasis suppressor 1
    Hs.336994  [show with all ESTs]
    Unigene Representative Sequence: NM_014751
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000378017(uc003yri.2) ENST00000518547(uc011lin.1 uc011lio.1 uc003yrk.2 uc003yrl.2)
    ENST00000520771(uc003yrh.2) ENST00000519168 ENST00000325064 ENST00000431961
    ENST00000523587 ENST00000524090 ENST00000523179 ENST00000520094 ENST00000522722
    ENST00000522118 ENST00000519226 ENST00000522162 ENST00000529463 ENST00000519671
    ENST00000524243 ENST00000472084

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTSS1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MTSS1 (see all 45):
    hsa-miR-596 hsa-miR-200a hsa-miR-141 hsa-miR-654-5p hsa-miR-532-5p hsa-miR-23a hsa-miR-28-5p hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmid: MTSS1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTSS1 (see all 6)
    OriGene siRNA: MTSS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTSS1
    Clone
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    GenScript: all cDNA clones in your preferred vector: MTSS1 (NM_014751)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTSS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTSS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTSS1

    Additional cDNA sequence: 

    AB007889.2 AF086645.1 AF116674.1 AK027015.1 AK126651.1 AK126989.1 AK295681.1 AK302036.1 
    AK310792.1 BC023998.1 EF560715.1 U50573.1 

    14 DOTS entries:

    DT.454840  DT.95137631  DT.95244731  DT.100752014  DT.99959639  DT.97844620  DT.91654072  DT.121486184 
    DT.121486474  DT.92429725  DT.121486151  DT.100657894  DT.100752013  DT.86853309 

    9 AceView cDNA sequences:

    BM675543 BF508649 BU535618 AW976253 BM931744 BX492881 BG913875 AI554562 
    BF674886 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MTSS1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^
    SP1:                          -     -     -                                                     -     -           -                                             
    SP2:                                                                                            -     -                 -                                       
    SP3:                                                                                            -     -           -     -     -                                 
    SP4:                                                                                            -     -           -     -                                       
    SP5:                                                                                            -     -           -                                             

    ExUns: 19a · 19b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MTSS1

    Expression
    for MTSS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTSS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTATTAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MTSS1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MTSS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTSS1

    SOURCE GeneReport for Unigene cluster: Hs.336994

    UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
    Tissue specificity: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and
    peripheral blood

        SABiosciences Expression via Pathway-Focused PCR Arrays including MTSS1: 
              Notch Signaling Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTSS1

    Orthologs
    for MTSS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MTSS1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mtss11 , 5 metastasis suppressor 11, 5 86.53(n)1
    93.29(a)1    		   15 (25.09 cM)5
    2114011  NM_001146180.11  NP_001139652.11 
     589412445 
    chicken
    (Gallus gallus)    		 Aves MTSS11 metastasis suppressor 1 80.31(n)
    87.87(a)    		   420336  NM_001030954.1  NP_001026125.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MTSS16
    		 --
    		 84(a)
    		 1 ↔ 1
    		 4(6215130-6251587)
    fruit fly
    (Drosophila melanogaster)    		 Insecta mim6
    		 missing-in-metastasis
    		 11(a)
    		 1 → many
    		 2R(2812192-2859142)
    worm
    (Caenorhabditis elegans)    		 Secernentea M04F3.56
    		 Protein M04F3.5
    		 18(a)
    		 possible ortholog
    		 I(4773819-4777718)


    ENSEMBL Gene Tree for MTSS1 (if available)
    TreeFam Gene Tree for MTSS1 (if available) 

    Paralogs
    for MTSS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTSS1 gene
    MTSS1L2  
    1 SIMAP similar gene for MTSS1 using alignment to 9 protein entries:     MTSS1_HUMAN (see all proteins):
    MTSS1L

    MTSS1 for paralogs           About GeneDecksing



    Genomic Variants
    for MTSS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3576 NCBI SNPs in MTSS1 are shown (see all 3576)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs779020621,2
    		F,--125562745(+) AAGGTA/GAGGGA 1 -- ds50013Minor allele frequency- G:0.34CSA WA 122
    rs1859548321,2
    		--125562846(+) TTTAGC/TTCTTG 1 -- ds50010--------
    rs1910466811,2
    		--125562906(+) TCTTAC/TAGCCA 1 -- ds50010--------
    rs123353141,2
    		C,F,H,--125563025(+) AGGACT/GTTTTT 1 -- ut317Minor allele frequency- G:0.04NS EA CSA WA 534
    rs751455981,2
    		--125563094(+) AGACAC/TATTAC 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1815340981,2
    		--125563125(+) TTTAGA/GACAAA 1 -- ut310--------
    rs1154934861,2
    		F,--125563159(+) TCTCAG/CTACAA 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs1858781021,2
    		--125563168(+) AAACTA/GGCAAC 1 -- ut310--------
    rs1912259601,2
    		--125563362(+) GCTGTA/GCCAAG 1 -- ut310--------
    rs727147081,2
    		C,--125563390(+) TATTTC/TAAAGG 1 -- ut314Minor allele frequency- T:0.14WA NA EA 360

    HapMap Linkage Disequilibrium report for MTSS1 (125563025 - 125740730 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MTSS1
         1 CNV: 43549
         1 Indel: 70431

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing MTSS1:
    Gastric Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTSS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MTSS1

    Disorders / Diseases
    for MTSS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MTSS1 for disorders           About GeneDecksing

    OMIM gene information: 608486    OMIM disorders: --

    9 diseases for MTSS1:    About MalaCards
    wiskott-aldrich syndrome    urinary bladder cancer    squamous cell carcinoma    huntington's disease
    hepatocellular carcinoma    prostate cancer    breast cancer    carcinoma
    prostatitis

    5 Novoseek disease relationships for MTSS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer metastatic 88 4 15870888 (1), 12482861 (1)
    wiskott-aldrich syndrome 75.1 2 15870888 (1), 12570871 (1)
    metastasis 41.4 17 12570871 (3), 16280553 (2), 15870888 (2), 15488640 (2) (see all 5)
    cancer 11.3 3 16280553 (1), 15870888 (1), 12570871 (1)
    tumors 0 1 15870888 (1)

    Human Genome Epidemiology (HuGE) Navigator: MTSS1 (3 documents)

    Export disorders for MTSS1 gene to outside databases

    Publications
    for MTSS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTSS1 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with MTSS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MIM, a potential metastasis suppressor gene in bladder cancer. (PubMed id 12082544)1, 2, 3 Lee Y.G....Pienta K.J. (2002)
    2. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. (PubMed id 12482861)1, 3, 9 Mattila P.K....Lappalainen P. (2003)
    3. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. (PubMed id 12570871)1, 2, 9 Woodings J.A.... Machesky L.M. (2003)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    7. Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. (PubMed id 15488640)1, 9 Nixdorf S....Jackson P. (2004)
    8. Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. (PubMed id 16280553)1, 9 Bompard G....Machesky L.M. (2005)
    9. [Expression and clinical significance of miR-23a and m etastasis suppressor 1 in colon carcinoma]. (PubMed id 22455847)1 Tang H.L....Su Q. (2012)
    10. MTSS1, a novel target of DNA methyltransferase 3B, fun ctions as a tumor suppressor in hepatocellular carcinoma. (PubMed id 21909138)1 Fan H....Guan X.Y. (2012)

    External Searches for MTSS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MTSS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9788 HGNC: 20443 AceView: MTSS1.1 Ensembl:ENSG00000170873 euGenes: HUgn9788
    ECgene: MTSS1 H-InvDB: MTSS1

    Other Databases showing MTSS1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0429

    Specialized Databases showing MTSS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTSS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTSS1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MTSS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MTSS1 gene:
    Search GeneIP for patents involving MTSS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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