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MTSS1 Gene

protein-coding   GIFtS: 60
GCID: GC08M125563

Metastasis Suppressor 1

  Search for MTSS1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metastasis Suppressor 11 2     KIAA04293 5
MIM2 3 5     MIMA2
Metastasis Suppressor YGL-12 3     MIMB2
Missing In Metastasis Protein2 3     Metastasis Suppressor Protein 12

External Ids:    HGNC: 204431   Entrez Gene: 97882   Ensembl: ENSG000001708737   OMIM: 6084865   UniProtKB: O433123   

Export aliases for MTSS1 gene to outside databases

Previous GC identifers: GC08M125567 GC08M125231 GC08M125519 GC08M125632 GC08M120888


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTSS1 Gene:
MTSS1 (metastasis suppressor 1) is a protein-coding gene. GO annotations related to this gene include SH3 domain binding and identical protein binding. An important paralog of this gene is MTSS1L.

UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
Function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely
through an interaction with the actin cytoskeleton

Gene Wiki entry for MTSS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTSS1 gene promoter:
         AhR   MyoD   RORalpha2   C/EBPalpha   AREB6   PPAR-gamma1   S8   c-Myb   PPAR-gamma2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MTSS1 promoter sequence
   Search Chromatin IP Primers for MTSS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTSS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8p22

MTSS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTSS1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M125563:  view genomic region     (about GC identifiers)

Start:
125,563,025 bp from pter      End:
125,740,730 bp from pter
Size:
177,706 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312 (See protein sequence)
Recommended Name: Metastasis suppressor protein 1  
Size: 755 amino acids; 82251 Da
Subunit: Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta
1 PDB 3D structure from and Proteopedia for MTSS1:
2D1K (3D)    
Secondary accessions: Q8TCA2 Q96RX2
Alternative splicing: 3 isoforms:  O43312-1   O43312-2   O43312-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTSS1: NX_O43312

Explore proteomics data for MTSS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTSS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269900.1  NP_001269903.1  NP_055566.3  

    ENSEMBL proteins: 
     ENSP00000367256   ENSP00000429064   ENSP00000428685   ENSP00000322804   ENSP00000393606  
     ENSP00000428319   ENSP00000428348   ENSP00000428145   ENSP00000429752   ENSP00000346119  
     ENSP00000378884  

    MTSS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MTSS1
    GenScript Custom Purified and Recombinant Proteins Services for MTSS1
    Novus Biologicals MTSS1 Protein
    Sino Biological Recombinant Protein for MTSS1
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTSS1

     
    Search eBioscience for Proteins for MTSS1 

    MTSS1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MTSS1 
    OriGene Antibodies for MTSS1
    OriGene Custom Antibody Services for MTSS1
    Novus Biologicals MTSS1 Antibodies
    Abcam antibodies for MTSS1
    Cloud-Clone Corp. Antibodies for MTSS1
    ThermoFisher Antibodies for MTSS1
    LSBio Antibodies in human, mouse, rat for MTSS1

    MTSS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MTSS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTSS1
    Cloud-Clone Corp. CLIAs for MTSS1
    Search eBioscience for ELISAs for MTSS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013606 IRSp53/MIM_homology_IMD
     IPR003124 WH2_dom
     IPR027682 MTSS1

    Graphical View of Domain Structure for InterPro Entry O43312

    ProtoNet protein and cluster: O43312

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
    Domain: The WH2 motif at the C-terminus binds to actin monomers
    Similarity: Belongs to the MTSS1 family
    Similarity: Contains 1 IMD (IRSp53/MIM homology) domain
    Similarity: Contains 1 WH2 domain


    Find genes that share domains with MTSS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTSS1_HUMAN, O43312
    Function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely
    through an interaction with the actin cytoskeleton

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ----
    GO:0003785actin monomer binding IDA12570871
    GO:0005102receptor binding IPI12570871
    GO:0005515protein binding IPI15383276
    GO:0008093cytoskeletal adaptor activity IEA--
         
    Find genes that share ontologies with MTSS1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mtss1):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  renal/urinary system  skeleton  tumorigenesis 

    Find genes that share phenotypes with MTSS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mtss1tm1Pla for MTSS1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTSS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTSS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTSS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTSS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTSS1:
    hsa-mir-192-5p (MIRT026400), hsa-mir-182-5p (MIRT006300), hsa-mir-215-5p (MIRT024949)

    Block miRNA regulation of human, mouse, rat MTSS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTSS1 (see all 45):
    hsa-miR-596 hsa-miR-200a hsa-miR-141 hsa-miR-654-5p hsa-miR-532-5p hsa-miR-23a hsa-miR-28-5p hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidMTSS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTSS1
    Predesigned siRNA for gene silencing in human, mouse, rat MTSS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTSS1

    Clone
    Products:
         
    OriGene clones in human, mouse for MTSS1 (see all 6)
    OriGene ORF clones in mouse, rat for MTSS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTSS1 (NM_014751)
    Sino Biological Human cDNA Clone for MTSS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTSS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTSS1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MTSS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTSS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTSS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTSS1_HUMAN, O43312: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle NAS12570871
    GO:0005737cytoplasm TAS12570871
    GO:0015629actin cytoskeleton IDA12570871
    GO:0030139endocytic vesicle TAS12570871

    Find genes that share ontologies with MTSS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTSS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Hedgehog signaling events mediated by Gli proteins
    Hedgehog signaling events mediated by Gli proteins
    2Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with MTSS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MTSS1
        Cytoskeletal Signaling

    1 BioSystems Pathway for MTSS1
        Hedgehog signaling events mediated by Gli proteins



        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTSS1: 
              Notch Signaling Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MTSS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MTSS1 (O433121, 2, 3 ENSP000003228044) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-473954,EBI-466029 MINT-3978180 MINT-3978484 MINT-3978605 I2D: score=3 STRING: ENSP00000347184
    CTTNQ142472, 3, ENSP000003018434MINT-7306884 I2D: score=2 STRING: ENSP00000301843
    PTPRDP234683, ENSP000003488124I2D: score=1 STRING: ENSP00000348812
    RECQL5O947623I2D: score=4 
    ACTA1P681333I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement NAS12570871
    GO:0007015actin filament organization ----
    GO:0007155cell adhesion NAS12570871
    GO:0007165signal transduction ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS12570871

    Find genes that share ontologies with MTSS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTSS1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTSS1 gene (3 alternative transcripts): 
    NM_001282971.1  NM_001282974.1  NM_014751.5  

    Unigene Cluster for MTSS1:

    Metastasis suppressor 1
    Hs.336994  [show with all ESTs]
    Unigene Representative Sequence: NM_014751
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000378017(uc003yri.2) ENST00000518547(uc011lin.1 uc011lio.1 uc003yrk.2 uc003yrl.2)
    ENST00000520771(uc003yrh.2) ENST00000519168 ENST00000325064 ENST00000431961
    ENST00000523587 ENST00000524090 ENST00000523179 ENST00000520094 ENST00000522722
    ENST00000522118 ENST00000519226 ENST00000522162 ENST00000529463 ENST00000519671
    ENST00000524243 ENST00000472084
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTSS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTSS1 (see all 45):
    hsa-miR-596 hsa-miR-200a hsa-miR-141 hsa-miR-654-5p hsa-miR-532-5p hsa-miR-23a hsa-miR-28-5p hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidMTSS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTSS1
    Predesigned siRNA for gene silencing in human, mouse, rat MTSS1
    Clone
    Products:
         
    OriGene clones in human, mouse for MTSS1 (see all 6)
    OriGene ORF clones in mouse, rat for MTSS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTSS1 (NM_014751)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTSS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTSS1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MTSS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTSS1
      QuantiTect SYBR Green Assays in human, mouse, rat MTSS1
      QuantiFast Probe-based Assays in human, mouse, rat MTSS1

    Additional mRNA sequence: 

    AB007889.2 AF086645.1 AF116674.1 AK027015.1 AK126651.1 AK126989.1 AK295681.1 AK302036.1 
    AK310792.1 BC023998.1 EF560715.1 U50573.1 

    14 DOTS entries:

    DT.454840  DT.95137631  DT.95244731  DT.100752014  DT.99959639  DT.97844620  DT.91654072  DT.121486184 
    DT.121486474  DT.92429725  DT.121486151  DT.100657894  DT.100752013  DT.86853309 

    9 AceView cDNA sequences:

    BF508649 BM675543 BU535618 BX492881 BM931744 AW976253 BG913875 AI554562 
    BF674886 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTSS1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^
    SP1:                          -     -     -                                                     -     -           -                                             
    SP2:                                                                                            -     -                 -                                       
    SP3:                                                                                            -     -           -     -     -                                 
    SP4:                                                                                            -     -           -     -                                       
    SP5:                                                                                            -     -           -                                             

    ExUns: 19a · 19b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MTSS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTSS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATTAGAA
    MTSS1 Expression
    About this image


    MTSS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Ventral/hypothalamic-like neurons
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Brain (Nervous System)
             Ventral/hypothalamic-like neurons
    MTSS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTSS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.336994

    UniProtKB/Swiss-Prot: MTSS1_HUMAN, O43312
    Tissue specificity: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and
    peripheral blood

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTSS1: 
              Notch Signaling Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MTSS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTSS1
    QuantiTect SYBR Green Assays in human, mouse, rat MTSS1
    QuantiFast Probe-based Assays in human, mouse, rat MTSS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTSS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTSS1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtss11 , 5 metastasis suppressor 11, 5 89.99(n)1
    96.57(a)1
      15 (25.09 cM)5
    2114011  NM_144800.21  NP_659049.21 
     589412445 
    chicken
    (Gallus gallus)
    Aves MTSS11 metastasis suppressor 1 80.31(n)
    87.87(a)
      420336  NM_001030954.1  NP_001026125.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTSS16
    metastasis suppressor 1
    77(a)
    1 ↔ 1
    4(6082134-6251587)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mtss1.11 metastasis suppressor 1, gene 1 75.29(n)
    83.02(a)
      780261  NM_001079332.1  NP_001072800.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-46l15.11 si:dkey-46l15.1 63.71(n)
    64.96(a)
      560131  NM_001123252.1  NP_001116724.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mim6
    missing-in-metastasis
    5(a)
    1 → many
    2R(2812192-2859142)
    worm
    (Caenorhabditis elegans)
    Secernentea M04F3.56
    Protein M04F3.5 (M04F3.5) mRNA, complete cds
    7(a)
    1 → many
    I(4773818-4777717) WBGene00019771


    ENSEMBL Gene Tree for MTSS1 (if available)
    TreeFam Gene Tree for MTSS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTSS1 gene
    MTSS1L2  
    1 SIMAP similar gene for MTSS1 using alignment to 9 protein entries:     MTSS1_HUMAN (see all proteins):
    MTSS1L

    Find genes that share paralogs with MTSS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTSS1 (see all 4139)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681100141,2
    C--120917847(+) TTTTT-/ATTTTTT 1 -- int11Minor allele frequency- AT:0.00NA 2
    rs779020621,2
    C,F--125562745(+) AAGGTA/GAGGGA 1 -- ds50013Minor allele frequency- G:0.34CSA WA 122
    rs1859548321,2
    --125562846(+) TTTAGC/TTCTTG 1 -- ds50010--------
    rs1910466811,2
    --125562906(+) TCTTAC/TAGCCA 1 -- ds50010--------
    rs123353141,2
    C,F,H--125563025(+) AGGACT/GTTTTT 1 -- ut317Minor allele frequency- G:0.04NS EA CSA WA 534
    rs751455981,2
    F--125563094(+) AGACAC/TATTAC 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1815340981,2
    --125563125(+) TTTAGA/GACAAA 1 -- ut310--------
    rs1154934861,2
    C,F--125563159(+) TCTCAG/CTACAA 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs1858781021,2
    --125563168(+) AAACTA/GGCAAC 1 -- ut310--------
    rs1912259601,2
    --125563362(+) GCTGTA/GCCAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MTSS1 (125563025 - 125740730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MTSS1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737533CNV Deletion23290073
    esv2737534CNV Deletion23290073
    esv5049CNV Deletion18987735
    esv2737535CNV Deletion23290073
    nsv507489CNV Insertion20534489
    nsv396843CNV Insertion16902084
    nsv465801CNV Loss19166990
    nsv465802CNV Loss19166990
    esv275526CNV Loss21479260
    nsv891434CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing MTSS1:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing MTSS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MTSS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608486    OMIM disorders: --


    Find genes that share disorders with MTSS1           About GenesLikeMe

    5 Novoseek inferred disease relationships for MTSS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer metastatic 88 4 15870888 (1), 12482861 (1)
    wiskott-aldrich syndrome 75.1 2 15870888 (1), 12570871 (1)
    metastasis 41.4 17 12570871 (3), 16280553 (2), 15870888 (2), 15488640 (2) (see all 5)
    cancer 11.3 3 16280553 (1), 15870888 (1), 12570871 (1)
    tumors 0 1 15870888 (1)

    Genetic Association Database (GAD): MTSS1
    Human Genome Epidemiology (HuGE) Navigator: MTSS1 (3 documents)

    Export disorders for MTSS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTSS1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with MTSS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MIM, a potential metastasis suppressor gene in bladder cancer. (PubMed id 12082544)1, 2, 3 Lee Y.-G.... Pienta K.J. (Neoplasia 2002)
    2. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. (PubMed id 12482861)1, 3, 9 Mattila P.K....Lappalainen P. (J. Biol. Chem. 2003)
    3. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. (PubMed id 12570871)1, 2, 9 Woodings J.A.... Machesky L.M. (Biochem. J. 2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    6. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1997)
    10. Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. (PubMed id 15488640)1, 9 Nixdorf S....Jackson P. (Cancer Lett. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9788 HGNC: 20443 AceView: MTSS1.1 Ensembl:ENSG00000170873 euGenes: HUgn9788
    ECgene: MTSS1 H-InvDB: MTSS1

    (According to HUGE)
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    HUGE: KIAA0429

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTSS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTSS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTSS1 gene:
    Search GeneIP for patents involving MTSS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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