Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTRNR2L8 Gene

Aliases for MTRNR2L8 Gene

  • MT-RNR2-Like 8 2 3 5
  • Humanin-Like 8 2 3
  • HN8 3 4
  • Humanin-Like Protein 8 3
  • MT-RNR2-Like Protein 8 4
  • MTRNR2-Like 8 3

External Ids for MTRNR2L8 Gene

Previous GeneCards Identifiers for MTRNR2L8 Gene

  • GC11U901604
  • GC11M010202
  • GC11M010537
  • GC11M010538
  • GC11M010539
  • GC11M010540
  • GC11M010548
  • GC11M010515
  • GC11M010521
  • GC11M010526
  • GC11M010550
  • GC11M010558

Summaries for MTRNR2L8 Gene

GeneCards Summary for MTRNR2L8 Gene

MTRNR2L8 (MT-RNR2-Like 8) is a Protein Coding gene. An important paralog of this gene is MTRNR2L12.

UniProtKB/Swiss-Prot for MTRNR2L8 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L8 Gene

Genomics for MTRNR2L8 Gene

Regulatory Elements for MTRNR2L8 Gene

Enhancers for MTRNR2L8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G010651 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -147.6 -147572 9.9 PKNOX1 ARNT WRNIP1 SIN3A YY1 ZNF766 FOS DEK SP5 JUNB MRVI1 LOC101928053 LYVE1 CTR9 MTRNR2L8 MRVI1-AS1 ADM GC11M010667
GH11G010385 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +121.6 121623 3.9 HDAC1 FOXA2 PKNOX1 TBL1XR1 SIN3A RARA TCF12 GATA2 FOS CEBPB MTRNR2L8 LYVE1 MRVI1 AMPD3 GC11M010399 RNU6ATAC33P PIR60970
GH11G010454 1.3 ENCODE dbSUPER 10.6 +51.9 51920 6.4 HDGF PKNOX1 FOXA2 ARNT WRNIP1 SIN3A YY1 CBX5 FOS JUNB CTR9 AMPD3 MTRNR2L8 RPL21P97 LYVE1 MRVI1 GC11M010466 GC11P010430
GH11G010449 1 ENCODE dbSUPER 10.6 +57.9 57851 3.2 HDGF TBP CTCF ZNF146 MAX RBBP5 EBF1 RAD21 TCF12 ZBTB48 AMPD3 CTR9 MTRNR2L8 LYVE1 MRVI1 GC11M010466 GC11P010430
GH11G010725 1 Ensembl ENCODE 9.8 -216.4 -216438 1.1 HDAC1 ESRRA JUN CEBPG FOSL1 FOS TCF7L2 SMARCE1 JUNB CEBPB MRVI1 LYVE1 MTRNR2L8 GC11P010725
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTRNR2L8 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTRNR2L8 Gene

Chromosome:
11
Start:
10,507,887 bp from pter
End:
10,509,189 bp from pter
Size:
1,303 bases
Orientation:
Minus strand

Genomic View for MTRNR2L8 Gene

Genes around MTRNR2L8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L8 Gene

Proteins for MTRNR2L8 Gene

  • Protein details for MTRNR2L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ75-HMN8_HUMAN
    Recommended name:
    Humanin-like 8
    Protein Accession:
    P0CJ75

    Protein attributes for MTRNR2L8 Gene

    Size:
    24 amino acids
    Molecular mass:
    2661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L8 Gene

Post-translational modifications for MTRNR2L8 Gene

No Post-translational modifications

Other Protein References for MTRNR2L8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L8 Gene

Domains & Families for MTRNR2L8 Gene

Protein Domains for MTRNR2L8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ75

UniProtKB/Swiss-Prot:

HMN8_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L8: view

No data available for Gene Families for MTRNR2L8 Gene

Function for MTRNR2L8 Gene

Molecular function for MTRNR2L8 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L8 Gene

Localization for MTRNR2L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L8 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L8 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L8: view

Pathways & Interactions for MTRNR2L8 Gene

SuperPathways for MTRNR2L8 Gene

No Data Available

Interacting Proteins for MTRNR2L8 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L8 Gene

Drugs & Compounds for MTRNR2L8 Gene

No Compound Related Data Available

Transcripts for MTRNR2L8 Gene

mRNA/cDNA for MTRNR2L8 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L8 Gene

MT-RNR2-like 8:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L8 Gene

No ASD Table

Relevant External Links for MTRNR2L8 Gene

GeneLoc Exon Structure for
MTRNR2L8
ECgene alternative splicing isoforms for
MTRNR2L8

Expression for MTRNR2L8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L8 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L8 Gene

This gene is overexpressed in Brain - Amygdala (x7.2), Brain - Putamen (basal ganglia) (x5.9), Brain - Anterior cingulate cortex (BA24) (x4.7), Brain - Substantia nigra (x4.4), and Brain - Frontal Cortex (BA9) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L8 Gene:

MTRNR2L8

SOURCE GeneReport for Unigene cluster for MTRNR2L8 Gene:

Hs.717003

mRNA Expression by UniProt/SwissProt for MTRNR2L8 Gene:

P0CJ75-HMN8_HUMAN
Tissue specificity: Highly expressed in the kidney, heart muscle and testis. Not expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with MTRNR2L8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L8 Gene

Orthologs for MTRNR2L8 Gene

Evolution for MTRNR2L8 Gene

ENSEMBL:
Gene Tree for MTRNR2L8 (if available)
TreeFam:
Gene Tree for MTRNR2L8 (if available)

No data available for Orthologs for MTRNR2L8 Gene

Paralogs for MTRNR2L8 Gene

Paralogs for MTRNR2L8 Gene

(7) SIMAP similar genes for MTRNR2L8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L8: view

Variants for MTRNR2L8 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs551737295 Uncertain significance 10,507,565(+) TAAAG(C/T)CAGCT downstream-variant-500B, utr-variant-3-prime
rs866636048 Uncertain significance 10,507,420(+) TGAAA(C/T)TGAAT downstream-variant-500B, utr-variant-3-prime
rs886047593 Uncertain significance 10,507,560(+) TTAAA(-/TAAA)GTCAG downstream-variant-500B, utr-variant-3-prime
rs1545743 Benign 10,507,469(+) CCCCC(A/G)TTTAT downstream-variant-500B, utr-variant-3-prime
rs1000344130 -- 10,508,381(+) ATTTG(A/C)CGAGT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L8 Gene

Variant ID Type Subtype PubMed ID
esv22967 CNV gain 19812545
esv3625358 CNV gain 21293372
nsv1044011 CNV gain 25217958
nsv972946 CNV duplication 23825009
nsv975881 CNV duplication 23825009

Variation tolerance for MTRNR2L8 Gene

Gene Damage Index Score: 0.06; 1.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTRNR2L8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTRNR2L8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L8 Gene

Disorders for MTRNR2L8 Gene

Relevant External Links for MTRNR2L8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTRNR2L8

No disorders were found for MTRNR2L8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L8 Gene

Publications for MTRNR2L8 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4 64
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C. … Breton S. (Mitochondrial DNA 2015) 3 64
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C. … Cohen P. (Trends Endocrinol. Metab. 2013) 3 64
  5. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E. … Collodel G. (Fertil. Steril. 2010) 3 64

Products for MTRNR2L8 Gene

Sources for MTRNR2L8 Gene

Content
Loading form....