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Aliases for MTRNR2L8 Gene

Aliases for MTRNR2L8 Gene

  • MT-RNR2-Like 8 2 3
  • Humanin-Like 8 2 3
  • HN8 3 4
  • Humanin-Like Protein 8 3
  • MT-RNR2-Like Protein 8 4
  • MTRNR2-Like 8 3

External Ids for MTRNR2L8 Gene

Summaries for MTRNR2L8 Gene

GeneCards Summary for MTRNR2L8 Gene

MTRNR2L8 (MT-RNR2-Like 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L8 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L8 Gene

Genomics for MTRNR2L8 Gene

Genomic Location for MTRNR2L8 Gene

Start:
10,507,887 bp from pter
End:
10,509,189 bp from pter
Size:
1,303 bases
Orientation:
Minus strand

Genomic View for MTRNR2L8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTRNR2L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L8 Gene

No data available for Regulatory Elements for MTRNR2L8 Gene

Proteins for MTRNR2L8 Gene

  • Protein details for MTRNR2L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ75-HMN8_HUMAN
    Recommended name:
    Humanin-like 8
    Protein Accession:
    P0CJ75
    Secondary Accessions:

    Protein attributes for MTRNR2L8 Gene

    Size:
    24 amino acids
    Molecular mass:
    2661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L8 Gene

Proteomics data for MTRNR2L8 Gene at MOPED

Post-translational modifications for MTRNR2L8 Gene

No Post-translational modifications

Other Protein References for MTRNR2L8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L8 Gene

Domains for MTRNR2L8 Gene

Protein Domains for MTRNR2L8 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HMN8_HUMAN
Family:
  • Belongs to the humanin family.:
    • P0CJ75
genes like me logo Genes that share domains with MTRNR2L8: view

No data available for Gene Families for MTRNR2L8 Gene

Function for MTRNR2L8 Gene

Molecular function for MTRNR2L8 Gene

UniProtKB/Swiss-Prot Function: Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction: Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MTRNR2L8 Gene

Localization for MTRNR2L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L8 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L8: view

Pathways for MTRNR2L8 Gene

SuperPathways for MTRNR2L8 Gene

No Data Available

Interacting Proteins for MTRNR2L8 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L8 Gene

None

No data available for Pathways by source for MTRNR2L8 Gene

Transcripts for MTRNR2L8 Gene

mRNA/cDNA for MTRNR2L8 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L8 Gene

MT-RNR2-like 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L8 Gene

No ASD Table

Relevant External Links for MTRNR2L8 Gene

GeneLoc Exon Structure for
MTRNR2L8
ECgene alternative splicing isoforms for
MTRNR2L8

Expression for MTRNR2L8 Gene

mRNA expression in normal human tissues for MTRNR2L8 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L8 Gene

This gene is overexpressed in Brain - Amygdala (7.2), Brain - Putamen (basal ganglia) (5.9), Brain - Anterior cingulate cortex (BA24) (4.7), Brain - Substantia nigra (4.4), and Brain - Frontal Cortex (BA9) (4.1).

SOURCE GeneReport for Unigene cluster for MTRNR2L8 Gene Hs.717003

mRNA Expression by UniProt/SwissProt for MTRNR2L8 Gene

P0CJ75-HMN8_HUMAN
Tissue specificity: Highly expressed in the kidney, heart muscle and testis. Not expressed in skeletal muscle.
genes like me logo Genes that share expressions with MTRNR2L8: view

Orthologs for MTRNR2L8 Gene

Evolution for MTRNR2L8 Gene

ENSEMBL:
Gene Tree for MTRNR2L8 (if available)
TreeFam:
Gene Tree for MTRNR2L8 (if available)

No data available for Orthologs for MTRNR2L8 Gene

Paralogs for MTRNR2L8 Gene

Selected SIMAP similar genes for MTRNR2L8 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MTRNR2L8 Gene

genes like me logo Genes that share paralogs with MTRNR2L8: view

No data available for Paralogs for MTRNR2L8 Gene

Variants for MTRNR2L8 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11042865 -- 10,510,897(+) AACAG(C/T)TGCAA upstream-variant-2KB
rs114842430 -- 10,510,603(+) TGCCT(C/T)GTGAA upstream-variant-2KB
rs116598783 -- 10,510,643(+) TTCAC(A/G)GCCTC upstream-variant-2KB
rs140122050 -- 10,510,465(+) AATTA(A/G)TTGTA upstream-variant-2KB
rs143831138 -- 10,510,905(+) CAAGC(A/G)TGTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L8 Gene

Variant ID Type Subtype PubMed ID
esv22967 CNV Gain 19812545

Relevant External Links for MTRNR2L8 Gene

HapMap Linkage Disequilibrium report
MTRNR2L8

Disorders for MTRNR2L8 Gene

No disorders were found for MTRNR2L8 Gene.

No data available for UniProtKB/Swiss-Prot for MTRNR2L8 Gene

Publications for MTRNR2L8 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  3. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PMID: 11371646) Hashimoto Y. … Nashimoto I. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3
  4. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PMID: 12009529) Tajima H. … Nishimoto I. (Neurosci. Lett. 2002) 3
  5. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PMID: 12732850) Guo B. … Reed J.C. (Nature 2003) 3

Products for MTRNR2L8 Gene

Sources for MTRNR2L8 Gene

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