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Aliases for MTRNR2L8 Gene

Aliases for MTRNR2L8 Gene

  • MT-RNR2-Like 8 2 3 5
  • Humanin-Like 8 2 3
  • HN8 3 4
  • Humanin-Like Protein 8 3
  • MT-RNR2-Like Protein 8 4
  • MTRNR2-Like 8 3

External Ids for MTRNR2L8 Gene

Previous GeneCards Identifiers for MTRNR2L8 Gene

  • GC11U901604
  • GC11M010202
  • GC11M010537
  • GC11M010538
  • GC11M010539
  • GC11M010540
  • GC11M010548
  • GC11M010515
  • GC11M010521
  • GC11M010526
  • GC11M010550
  • GC11M010558
  • GC11M010565
  • GC11M010570

Summaries for MTRNR2L8 Gene

GeneCards Summary for MTRNR2L8 Gene

MTRNR2L8 (MT-RNR2-Like 8) is a Protein Coding gene. An important paralog of this gene is MTRNR2L12.

UniProtKB/Swiss-Prot for MTRNR2L8 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

Additional gene information for MTRNR2L8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L8 Gene

Genomics for MTRNR2L8 Gene

GeneHancer (GH) Regulatory Elements for MTRNR2L8 Gene

Promoters and enhancers for MTRNR2L8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I010509 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 550.8 -0.1 -112 1 GC11M010511 MTRNR2L8 PIR32636 PIR43375 MIR4485 MRVI1-AS1
GH11I010508 Promoter 0.5 EPDnew 550.8 +0.5 485 0.1 GC11M010511 MTRNR2L8 PIR32636 MIR4485 PIR43375
GH11I010507 Enhancer 0.4 Ensembl ENCODE 550.8 +1.1 1147 0.5 GC11M010511 MTRNR2L8 MIR4485 PIR43375 MRVI1-AS1 GC11M010474
GH11I010510 Enhancer 0.2 ENCODE 550.8 -1.1 -1060 0.2 GC11M010511 MTRNR2L8 PIR32636 MIR4485 PIR43375 GC11M010583
GH11I010512 Enhancer 0.2 ENCODE 550.8 -0.8 -840 0.2 GC11M010511 MTRNR2L8 PIR32636 MIR4485 PIR43375 RNF141
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTRNR2L8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTRNR2L8 Gene

Genomic Locations for MTRNR2L8 Gene
1,303 bases
Minus strand

Genomic View for MTRNR2L8 Gene

Genes around MTRNR2L8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L8 Gene

Proteins for MTRNR2L8 Gene

  • Protein details for MTRNR2L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 8
    Protein Accession:

    Protein attributes for MTRNR2L8 Gene

    24 amino acids
    Molecular mass:
    2661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L8 Gene

Post-translational modifications for MTRNR2L8 Gene

No Post-translational modifications

Other Protein References for MTRNR2L8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L8 Gene

Domains & Families for MTRNR2L8 Gene

Gene Families for MTRNR2L8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTRNR2L8 Gene


Suggested Antigen Peptide Sequences for MTRNR2L8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L8: view

Function for MTRNR2L8 Gene

Molecular function for MTRNR2L8 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Phenotypes From GWAS Catalog for MTRNR2L8 Gene

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L8 Gene

Localization for MTRNR2L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L8 Gene

Secreted. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L8 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L8 Gene

Pathways & Interactions for MTRNR2L8 Gene

SuperPathways for MTRNR2L8 Gene

No Data Available

Interacting Proteins for MTRNR2L8 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L8 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L8 Gene

Drugs & Compounds for MTRNR2L8 Gene

No Compound Related Data Available

Transcripts for MTRNR2L8 Gene

mRNA/cDNA for MTRNR2L8 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L8 Gene

MT-RNR2-like 8:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L8 Gene

No ASD Table

Relevant External Links for MTRNR2L8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L8 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L8 Gene

This gene is overexpressed in Brain - Amygdala (x7.2), Brain - Putamen (basal ganglia) (x5.9), Brain - Anterior cingulate cortex (BA24) (x4.7), Brain - Substantia nigra (x4.4), and Brain - Frontal Cortex (BA9) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L8 Gene:


SOURCE GeneReport for Unigene cluster for MTRNR2L8 Gene:


mRNA Expression by UniProt/SwissProt for MTRNR2L8 Gene:

Tissue specificity: Highly expressed in the kidney, heart muscle and testis. Not expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with MTRNR2L8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L8 Gene

Orthologs for MTRNR2L8 Gene

Evolution for MTRNR2L8 Gene

Gene Tree for MTRNR2L8 (if available)
Gene Tree for MTRNR2L8 (if available)

No data available for Orthologs for MTRNR2L8 Gene

Paralogs for MTRNR2L8 Gene

Paralogs for MTRNR2L8 Gene

(7) SIMAP similar genes for MTRNR2L8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L8: view

Variants for MTRNR2L8 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1545743 benign, Erythrocyte AMP deaminase deficiency 10,507,469(-) G/A downstream_transcript_variant
rs551737295 uncertain-significance, Erythrocyte AMP deaminase deficiency 10,507,565(-) T/C downstream_transcript_variant
rs752754496 uncertain-significance, Erythrocyte AMP deaminase deficiency 10,507,556(-) TAAATAAA/TAAA downstream_transcript_variant
rs866636048 uncertain-significance, Erythrocyte AMP deaminase deficiency 10,507,420(-) T/C downstream_transcript_variant
rs1000344130 -- 10,508,381(-) C/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L8 Gene

Variant ID Type Subtype PubMed ID
esv22967 CNV gain 19812545
esv3625358 CNV gain 21293372
nsv1044011 CNV gain 25217958
nsv972946 CNV duplication 23825009
nsv975881 CNV duplication 23825009

Variation tolerance for MTRNR2L8 Gene

Gene Damage Index Score: 0.06; 1.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTRNR2L8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L8 Gene

Disorders for MTRNR2L8 Gene

Additional Disease Information for MTRNR2L8

No disorders were found for MTRNR2L8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L8 Gene

Publications for MTRNR2L8 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  3. Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity. (PMID: 27528462) Pantazatos SP … Mann JJ (Molecular psychiatry 2017) 3 58
  4. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C … Breton S (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2016) 3 58
  5. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C … Cohen P (Trends in endocrinology and metabolism: TEM 2013) 3 58

Products for MTRNR2L8 Gene

Sources for MTRNR2L8 Gene

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