MTRNR2L7 Gene
protein-coding GIFtS: 26
GCID: GC10M037895
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MT-RNR2-like 7
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Aliases
for MTRNR2L7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MT-RNR2-Like 71 2 | | HN72 3 | | MT-RNR2-Like Protein 72 3 | | Humanin 72 | | Humanin-Like Protein 72 | | MTRNR2-Like 72 |
Export aliases for MTRNR2L7 gene to outside databasesPrevious GC identifers: GC10M037892 GC10M037893 |
Summaries
for MTRNR2L7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)
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Genomic Views
for MTRNR2L7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MTRNR2L7
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTRNR2L7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTRNR2L7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p11.21 Ensembl cytogenetic band: 10p11.21 HGNC cytogenetic band: 10p11.21MTRNR2L7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M037895: view genomic region
(about GC identifiers)
Start:
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37,890,366 bp from pter |
End:
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37,891,859 bp from pter |
Size:
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1,494 bases |
Orientation:
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minus strand |
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Proteins
for MTRNR2L7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74 (See
protein sequence)Recommended Name: Humanin-like protein 7 Size: 24 amino acids; 2647 Da
Subcellular location: Cytoplasm (By similarity). Secreted (By similarity)Explore the universe of human proteins at neXtProt for MTRNR2L7: NX_P0CJ74
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CJ74
MTRNR2L7 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001177418.1
ENSEMBL proteins: ENSP00000439985
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
IEA | -- | | GO:0005737 | cytoplasm |
IEA | -- |
MTRNR2L7 for ontologies About GeneDecksing
MTRNR2L7 Antibody Products:
Assay Products for MTRNR2L7: |
Protein
Domains /
Families
for MTRNR2L7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P0CJ74 UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74Similarity: Belongs to the humanin family |
Function
for MTRNR2L7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)Induction: Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STStreatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours followingbeta-carotene treatment
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Pathways & Interactions
for MTRNR2L7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTRNR2L7
|
Drugs & Compounds
for MTRNR2L7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTRNR2L7
Search CenterWatch for drugs/clinical trials and news about MTRNR2L7 / HMN7 
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Transcripts
for MTRNR2L7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTRNR2L7 gene: NM_001190489.1 Unigene Cluster for MTRNR2L7: MT-RNR2-like 7 Hs.727092 Unigene Representative Sequence: NM_0011904891 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000544824(uc021ppd.1)
GeneLoc Exon Structure
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Expression
for MTRNR2L7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTRNR2L7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.727092
UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74Tissue specificity: Expressed in testis
SABiosciences Custom PCR Arrays for MTRNR2L7
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MTRNR2L7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTRNR2L7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTRNR2L7 |
Orthologs
for MTRNR2L7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for MTRNR2L7 (if available)
TreeFam Gene Tree for MTRNR2L7 (if available) |
Paralogs
for MTRNR2L7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MTRNR2L7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTRNR2L7 (37890366 - 37891859 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MTRNR2L7: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MTRNR2L7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTRNR2L7 for disorders About GeneDecksing
2  diseases for MTRNR2L7: About MalaCardsalzheimer's disease neuronitis
Export disorders for MTRNR2L7 gene to outside databases
|
Publications
for MTRNR2L7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTRNR2L7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MTRNR2L7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evidence for potential functionality of nuclearly-enc oded humanin isoforms. (PubMed id 19477263)1, 2, 3 Bodzioch M....Dembinska-Kiec A. (2009)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PubMed id 12009529)1 Tajima H.... Nishimoto I. (2002)
- A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PubMed id 11371646)1 Hashimoto Y.... Nashimoto I. (2001)
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External Searches for MTRNR2L7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MTRNR2L7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MTRNR2L7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTRNR2L7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTRNR2L7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MTRNR2L7 gene:
Search GeneIP for patents involving MTRNR2L7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTRNR2L7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTRNR2L7 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTRNR2L7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTRNR2L7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTRNR2L7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTRNR2L7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTRNR2L7 |
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 | | | MTRNR2L7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MTRNR2L7 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MTRNR2L7 |
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