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MTRNR2L7 Gene

protein-coding   GIFtS: 26
GCID: GC10M037895

MT-RNR2-Like 7

  See MTRNR2L7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MT-RNR2-Like 71 2
Humanin-Like 71 2
HN72 3
Humanin-Like Protein 72
MTRNR2-Like 72
MT-RNR2-Like Protein 73

External Ids:    HGNC: 371641   Entrez Gene: 1002884852   Ensembl: ENSG000002568927   UniProtKB: P0CJ743   

Export aliases for MTRNR2L7 gene to outside databases

Previous GC identifers: GC10M037892 GC10M037893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTRNR2L7 Gene:
MTRNR2L7 (MT-RNR2-like 7) is a protein-coding gene. Diseases associated with MTRNR2L7 include alzheimer's disease.

UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74
Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MTRNR2L7
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MTRNR2L7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTRNR2L7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21   Ensembl cytogenetic band:  10p11.21   HGNC cytogenetic band: 10p11.21

MTRNR2L7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTRNR2L7 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M037895:  view genomic region     (about GC identifiers)

Start:
37,890,366 bp from pter      End:
37,891,859 bp from pter
Size:
1,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74 (See protein sequence)
Recommended Name: Humanin-like protein 7  
Size: 24 amino acids; 2647 Da

Explore the universe of human proteins at neXtProt for MTRNR2L7: NX_P0CJ74

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001177418.1  
    ENSEMBL proteins: 
     ENSP00000439985  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028139 Humanin

    Graphical View of Domain Structure for InterPro Entry P0CJ74

    ProtoNet protein and cluster: P0CJ74

    UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74
    Similarity: Belongs to the humanin family


    Find genes that share domains with MTRNR2L7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMN7_HUMAN, P0CJ74
    Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)
    Induction: Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS
    treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours
    following beta-carotene treatment

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMN7_HUMAN, P0CJ74: Cytoplasm (By similarity). Secreted (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with MTRNR2L7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTRNR2L7
    Interactions:

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTRNR2L7 gene: 
    NM_001190489.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000544824(uc021ppd.1)
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTRNR2L7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MTRNR2L7 Expression
    About this image

    MTRNR2L7 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    UniProtKB/Swiss-Prot: HMN7_HUMAN, P0CJ74
    Tissue specificity: Expressed in testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTRNR2L7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for MTRNR2L7 (if available)
    TreeFam Gene Tree for MTRNR2L7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTRNR2L7 gene
    1 SIMAP similar gene for MTRNR2L7 using alignment to 1 protein entry:     HMN7_HUMAN:
    MTRNR2L10

    Find genes that share paralogs with MTRNR2L7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTRNR2L7 (see all 101)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881168361,2
    --37890018(+) AGATGA/GTCTGG 1 -- ds50010--------
    rs107409421,2
    C,F,A,H--37890024(+) TCTGGT/CATAGG 1 -- ds500117Minor allele frequency- C:0.38NS EA NA WA CSA 796
    rs1901690701,2
    --37890032(+) AGGGAA/GGGGAG 1 -- ds50010--------
    rs1138514331,2
    C,F--37890118(+) GTAAGA/G/TGTTCT 1 -- ds50010--------
    rs1145932601,2
    C,F--37890183(+) ACAATG/ATTGGG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1866697641,2
    --37890188(+) GTTGGA/GTCCCT 1 -- ds50010--------
    rs1404405091,2
    --37890293(+) TATAGA/GCATGT 1 -- ds50010--------
    rs1911192501,2
    --37890297(+) GGCATA/GTAGTT 1 -- ds50010--------
    rs115996941,2
    C,F,A,H--37890319(+) TTCAAC/TTCTGA 1 -- ds50015Minor allele frequency- T:0.00NS EA NA 540
    rs1848426091,2
    --37890353(+) AATTGA/CTGGGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MTRNR2L7 (37890366 - 37891859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MTRNR2L7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895030CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for MTRNR2L7:    
    About MalaCards
    alzheimer's disease


    Find genes that share disorders with MTRNR2L7           About GenesLikeMe

    Genetic Association Database (GAD): MTRNR2L7

    Export disorders for MTRNR2L7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTRNR2L7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MTRNR2L7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PubMed id 19477263)1, 2, 3 Bodzioch M....Dembinska-Kiec A. (Genomics 2009)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    3. Humanin: a harbinger of mitochondrial-derived peptides? (PubMed id 23402768)1 Lee C....Cohen P. (Trends Endocrinol. Metab. 2013)
    4. Immunolocalization of humanin in human sperm and testis. (PubMed id 20542501)1 Moretti E....Collodel G. (Fertil. Steril. 2010)
    5. Common body mass index-associated variants confer risk of extreme obesity. (PubMed id 19553259)4 Cotsapas C....Daly M.J. (Hum. Mol. Genet. 2009)
    6. Humanin: a novel central regulator of peripheral insulin action. (PubMed id 19623253)1 Muzumdar R.H....Cohen P. (PLoS ONE 2009)
    7. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PubMed id 12732850)1 Guo B....Reed J.C. (Nature 2003)
    8. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PubMed id 12009529)1 Tajima H.... Nishimoto I. (Neurosci. Lett. 2002)
    9. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PubMed id 11371646)1 Hashimoto Y.... Nashimoto I. (Proc. Natl. Acad. Sci. U.S.A. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100288485 HGNC: 37164 Ensembl:ENSG00000256892 euGenes: HUgn100288485 ECgene: MTRNR2L7
    H-InvDB: MTRNR2L7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTRNR2L7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTRNR2L7 gene:
    Search GeneIP for patents involving MTRNR2L7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTRNR2L7
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MTRNR2L7
     Browse SwitchGear Promoter luciferase reporter plasmids for MTRNR2L7
     Search ThermoFisher Antibodies for MTRNR2L7
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MTRNR2L7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTRNR2L7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTRNR2L7
     Search LSBio for Antibodies for MTRNR2L7
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     Browse compounds at ApexBio
     Search Addgene for plasmids for MTRNR2L7
      Search eBioscience for proteins for MTRNR2L7
      Search eBioscience for elisas for MTRNR2L7
      eBioscience FlowRNA Probe Sets
           
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