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Aliases for MTRNR2L6 Gene

Aliases for MTRNR2L6 Gene

  • MT-RNR2-Like 6 2 3
  • Humanin-Like 6 2 3
  • HN6 3 4
  • Humanin-Like Protein 6 3
  • MT-RNR2-Like Protein 6 4
  • MTRNR2-Like 6 3

External Ids for MTRNR2L6 Gene

Summaries for MTRNR2L6 Gene

GeneCards Summary for MTRNR2L6 Gene

MTRNR2L6 (MT-RNR2-Like 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L6 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L6 Gene

Genomics for MTRNR2L6 Gene

Genomic Location for MTRNR2L6 Gene

Start:
142,666,272 bp from pter
End:
142,667,718 bp from pter
Size:
1,447 bases
Orientation:
Plus strand

Genomic View for MTRNR2L6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTRNR2L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L6 Gene

No data available for Regulatory Elements for MTRNR2L6 Gene

Proteins for MTRNR2L6 Gene

  • Protein details for MTRNR2L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ73-HMN6_HUMAN
    Recommended name:
    Humanin-like 6
    Protein Accession:
    P0CJ73
    Secondary Accessions:

    Protein attributes for MTRNR2L6 Gene

    Size:
    24 amino acids
    Molecular mass:
    2719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L6 Gene

Proteomics data for MTRNR2L6 Gene at MOPED

Post-translational modifications for MTRNR2L6 Gene

No Post-translational modifications

Other Protein References for MTRNR2L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L6 Gene

Domains for MTRNR2L6 Gene

Protein Domains for MTRNR2L6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HMN6_HUMAN
Family:
  • Belongs to the humanin family.:
    • P0CJ73
genes like me logo Genes that share domains with MTRNR2L6: view

No data available for Gene Families for MTRNR2L6 Gene

Function for MTRNR2L6 Gene

Molecular function for MTRNR2L6 Gene

UniProtKB/Swiss-Prot Function: Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction: Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MTRNR2L6 Gene

Localization for MTRNR2L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L6 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L6: view

Pathways for MTRNR2L6 Gene

SuperPathways for MTRNR2L6 Gene

No Data Available

Interacting Proteins for MTRNR2L6 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L6 Gene

None

No data available for Pathways by source for MTRNR2L6 Gene

Transcripts for MTRNR2L6 Gene

mRNA/cDNA for MTRNR2L6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L6 Gene

MT-RNR2-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L6 Gene

No ASD Table

Relevant External Links for MTRNR2L6 Gene

GeneLoc Exon Structure for
MTRNR2L6
ECgene alternative splicing isoforms for
MTRNR2L6

Expression for MTRNR2L6 Gene

mRNA expression in normal human tissues for MTRNR2L6 Gene

SOURCE GeneReport for Unigene cluster for MTRNR2L6 Gene Hs.727419

mRNA Expression by UniProt/SwissProt for MTRNR2L6 Gene

P0CJ73-HMN6_HUMAN
Tissue specificity: Expressed in skeletal muscle and testis.
genes like me logo Genes that share expressions with MTRNR2L6: view

Orthologs for MTRNR2L6 Gene

Evolution for MTRNR2L6 Gene

ENSEMBL:
Gene Tree for MTRNR2L6 (if available)
TreeFam:
Gene Tree for MTRNR2L6 (if available)

No data available for Orthologs for MTRNR2L6 Gene

Paralogs for MTRNR2L6 Gene

Selected SIMAP similar genes for MTRNR2L6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L6: view

No data available for Paralogs for MTRNR2L6 Gene

Variants for MTRNR2L6 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2156964 -- 142,664,755(+) AACAC(C/T)CCCCT upstream-variant-2KB
rs2187633 -- 142,664,497(+) ACTGC(C/T)GTGCA upstream-variant-2KB
rs2367330 -- 142,665,363(+) TATCA(A/G)GCACG upstream-variant-2KB
rs2367331 -- 142,665,502(+) CCACC(A/G)CAGCC upstream-variant-2KB
rs2367332 -- 142,665,601(+) AACCC(G/T)GGCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L6 Gene

Variant ID Type Subtype PubMed ID
nsv831166 CNV Gain+Loss 17160897
nsv428187 CNV Loss 18775914
dgv2145e1 CNV Complex 17122850
dgv841n27 CNV Loss 19166990
essv19150 CNV CNV 17122850
nsv824336 CNV Loss 20364138
esv34617 CNV Loss 17911159
nsv465170 CNV Loss 19166990
nsv8223 CNV Loss 18304495
nsv824337 CNV Loss 20364138

Relevant External Links for MTRNR2L6 Gene

HapMap Linkage Disequilibrium report
MTRNR2L6

Disorders for MTRNR2L6 Gene

Relevant External Links for MTRNR2L6

Genetic Association Database (GAD)
MTRNR2L6
genes like me logo Genes that share disorders with MTRNR2L6: view

No data available for UniProtKB/Swiss-Prot for MTRNR2L6 Gene

Publications for MTRNR2L6 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PMID: 11371646) Hashimoto Y. … Nashimoto I. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3
  4. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PMID: 12009529) Tajima H. … Nishimoto I. (Neurosci. Lett. 2002) 3
  5. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PMID: 12732850) Guo B. … Reed J.C. (Nature 2003) 3

Products for MTRNR2L6 Gene

Sources for MTRNR2L6 Gene

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