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Aliases for MTRNR2L6 Gene

Aliases for MTRNR2L6 Gene

  • MT-RNR2-Like 6 2 3 5
  • Humanin-Like 6 2 3
  • HN6 3 4
  • Humanin-Like Protein 6 3
  • MT-RNR2-Like Protein 6 4
  • MTRNR2-Like 6 3

External Ids for MTRNR2L6 Gene

Previous GeneCards Identifiers for MTRNR2L6 Gene

  • GC07U902933
  • GC07P142375
  • GC07P142377
  • GC07P142393
  • GC07P142435
  • GC07P142482
  • GC07P142639
  • GC07P142709
  • GC07P142771
  • GC07P142817
  • GC07P142881
  • GC07P143012
  • GC07P143161

Summaries for MTRNR2L6 Gene

GeneCards Summary for MTRNR2L6 Gene

MTRNR2L6 (MT-RNR2-Like 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L6 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L6 Gene

Genomics for MTRNR2L6 Gene

Regulatory Elements for MTRNR2L6 Gene

Enhancers for MTRNR2L6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F142669 0.6 ENCODE 0.8 +3.2 3222 0.2 CTCF SMC3 TRIM22 REST RAD21 TRBV25-1 MTRNR2L6
GH07F142670 0.6 Ensembl 0.8 +3.0 3030 0.2 CTCF SMC3 TRIM22 REST RAD21 TRBV25-1 MTRNR2L6
GH07F142668 0.4 Ensembl 0.8 +2.6 2629 0.2 IKZF1 TRBV25-1 MTRNR2L6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTRNR2L6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTRNR2L6 Gene

142,666,272 bp from pter
142,667,718 bp from pter
1,447 bases
Plus strand

Genomic View for MTRNR2L6 Gene

Genes around MTRNR2L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L6 Gene

Proteins for MTRNR2L6 Gene

  • Protein details for MTRNR2L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 6
    Protein Accession:

    Protein attributes for MTRNR2L6 Gene

    24 amino acids
    Molecular mass:
    2719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L6 Gene

Post-translational modifications for MTRNR2L6 Gene

No Post-translational modifications

Other Protein References for MTRNR2L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L6 Gene

Domains & Families for MTRNR2L6 Gene

Protein Domains for MTRNR2L6 Gene


Suggested Antigen Peptide Sequences for MTRNR2L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L6: view

No data available for Gene Families for MTRNR2L6 Gene

Function for MTRNR2L6 Gene

Molecular function for MTRNR2L6 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L6 Gene

Localization for MTRNR2L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L6 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L6: view

No data available for Subcellular locations from COMPARTMENTS for MTRNR2L6 Gene

Pathways & Interactions for MTRNR2L6 Gene

SuperPathways for MTRNR2L6 Gene

No Data Available

Interacting Proteins for MTRNR2L6 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L6 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L6 Gene

Transcripts for MTRNR2L6 Gene

mRNA/cDNA for MTRNR2L6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L6 Gene

MT-RNR2-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L6 Gene

No ASD Table

Relevant External Links for MTRNR2L6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTRNR2L6 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L6 Gene:


SOURCE GeneReport for Unigene cluster for MTRNR2L6 Gene:


mRNA Expression by UniProt/SwissProt for MTRNR2L6 Gene:

Tissue specificity: Expressed in skeletal muscle and testis.
genes like me logo Genes that share expression patterns with MTRNR2L6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MTRNR2L6 Gene

Orthologs for MTRNR2L6 Gene

Evolution for MTRNR2L6 Gene

Gene Tree for MTRNR2L6 (if available)
Gene Tree for MTRNR2L6 (if available)

No data available for Orthologs for MTRNR2L6 Gene

Paralogs for MTRNR2L6 Gene

(5) SIMAP similar genes for MTRNR2L6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L6: view

No data available for Paralogs for MTRNR2L6 Gene

Variants for MTRNR2L6 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10231856 -- 142,664,839(+) CAACT(C/G)TGCCA upstream-variant-2KB
rs10232003 -- 142,665,017(+) CACCC(A/C)GAAAG upstream-variant-2KB
rs10232237 -- 142,665,178(+) ATATA(C/T)AGTTA upstream-variant-2KB
rs10247233 -- 142,664,932(+) CCCTC(A/G)CCAAT upstream-variant-2KB
rs10260647 -- 142,665,040(+) ACCTT(A/G)TACTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L6 Gene

Variant ID Type Subtype PubMed ID
nsv981597 CNV duplication 23825009
nsv971553 CNV duplication 23825009
nsv831166 CNV gain+loss 17160897
nsv831165 CNV gain 17160897
nsv824337 CNV loss 20364138
nsv824336 CNV loss 20364138
nsv8223 CNV loss 18304495
nsv608630 CNV loss 21841781
nsv470396 CNV loss 18288195
nsv465170 CNV loss 19166990
nsv465148 CNV loss 19166990
nsv428187 CNV loss 18775914
nsv1029719 CNV loss 25217958
nsv1018286 CNV gain 25217958
esv3615286 CNV loss 21293372
esv3576450 CNV gain 25503493
esv34617 CNV loss 17911159
esv2759569 CNV loss 17122850
dgv841n27 CNV loss 19166990
dgv11652n54 CNV loss 21841781
dgv11644n54 CNV loss 21841781

Variation tolerance for MTRNR2L6 Gene

Gene Damage Index Score: 0.18; 3.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTRNR2L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L6 Gene

Disorders for MTRNR2L6 Gene

Relevant External Links for MTRNR2L6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MTRNR2L6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L6 Gene

Publications for MTRNR2L6 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4 64
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C. … Breton S. (Mitochondrial DNA 2015) 3 64
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C. … Cohen P. (Trends Endocrinol. Metab. 2013) 3 64
  5. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E. … Collodel G. (Fertil. Steril. 2010) 3 64

Products for MTRNR2L6 Gene

Sources for MTRNR2L6 Gene

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