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Aliases for MTRNR2L6 Gene

Aliases for MTRNR2L6 Gene

  • MT-RNR2-Like 6 2 3
  • HN6 3 4
  • Humanin-Like Protein 6 3
  • MT-RNR2-Like Protein 6 4
  • Humanin-Like 6 2
  • MTRNR2-Like 6 3

External Ids for MTRNR2L6 Gene

Previous GeneCards Identifiers for MTRNR2L6 Gene

  • GC07U902933
  • GC07P142375
  • GC07P142377
  • GC07P142393
  • GC07P142435
  • GC07P142482
  • GC07P142639
  • GC07P142709
  • GC07P142771
  • GC07P142817

Summaries for MTRNR2L6 Gene

GeneCards Summary for MTRNR2L6 Gene

MTRNR2L6 (MT-RNR2-Like 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L6 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L6 Gene

Genomics for MTRNR2L6 Gene

Genomic Location for MTRNR2L6 Gene

142,666,272 bp from pter
142,667,718 bp from pter
1,447 bases
Plus strand

Genomic View for MTRNR2L6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTRNR2L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L6 Gene

No data available for Regulatory Elements for MTRNR2L6 Gene

Proteins for MTRNR2L6 Gene

  • Protein details for MTRNR2L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 6
    Protein Accession:

    Protein attributes for MTRNR2L6 Gene

    24 amino acids
    Molecular mass:
    2719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L6 Gene

Proteomics data for MTRNR2L6 Gene at MOPED

Post-translational modifications for MTRNR2L6 Gene

No Post-translational modifications

Other Protein References for MTRNR2L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L6 Gene

Domains & Families for MTRNR2L6 Gene

Protein Domains for MTRNR2L6 Gene


Suggested Antigen Peptide Sequences for MTRNR2L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L6: view

No data available for Gene Families for MTRNR2L6 Gene

Function for MTRNR2L6 Gene

Molecular function for MTRNR2L6 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L6 Gene

Localization for MTRNR2L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L6 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L6: view

No data available for Subcellular locations from COMPARTMENTS for MTRNR2L6 Gene

Pathways & Interactions for MTRNR2L6 Gene

SuperPathways for MTRNR2L6 Gene

No Data Available

Interacting Proteins for MTRNR2L6 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L6 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L6 Gene

Drugs & Compounds for MTRNR2L6 Gene

No Compound Related Data Available

Transcripts for MTRNR2L6 Gene

mRNA/cDNA for MTRNR2L6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L6 Gene

MT-RNR2-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L6 Gene

No ASD Table

Relevant External Links for MTRNR2L6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L6 Gene

mRNA expression in normal human tissues for MTRNR2L6 Gene

SOURCE GeneReport for Unigene cluster for MTRNR2L6 Gene Hs.727419

mRNA Expression by UniProt/SwissProt for MTRNR2L6 Gene

Tissue specificity: Expressed in skeletal muscle and testis.
genes like me logo Genes that share expression patterns with MTRNR2L6: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MTRNR2L6 Gene

Orthologs for MTRNR2L6 Gene

Evolution for MTRNR2L6 Gene

Gene Tree for MTRNR2L6 (if available)
Gene Tree for MTRNR2L6 (if available)

No data available for Orthologs for MTRNR2L6 Gene

Paralogs for MTRNR2L6 Gene

(5) SIMAP similar genes for MTRNR2L6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L6: view

No data available for Paralogs for MTRNR2L6 Gene

Variants for MTRNR2L6 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2156964 -- 142,664,755(+) AACAC(C/T)CCCCT upstream-variant-2KB
rs2187633 -- 142,664,497(+) ACTGC(C/T)GTGCA upstream-variant-2KB
rs2367330 -- 142,665,363(+) TATCA(A/G)GCACG upstream-variant-2KB
rs2367331 -- 142,665,502(+) CCACC(A/G)CAGCC upstream-variant-2KB
rs2367332 -- 142,665,601(+) AACCC(G/T)GGCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L6 Gene

Variant ID Type Subtype PubMed ID
nsv831166 CNV Gain+Loss 17160897
nsv428187 CNV Loss 18775914
dgv2145e1 CNV Complex 17122850
dgv841n27 CNV Loss 19166990
essv19150 CNV CNV 17122850
nsv824336 CNV Loss 20364138
esv34617 CNV Loss 17911159
nsv465170 CNV Loss 19166990
nsv8223 CNV Loss 18304495
nsv824337 CNV Loss 20364138

Variation tolerance for MTRNR2L6 Gene

Gene Damage Index Score: 0.18; 3.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTRNR2L6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L6 Gene

Disorders for MTRNR2L6 Gene

Relevant External Links for MTRNR2L6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MTRNR2L6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L6 Gene

Publications for MTRNR2L6 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 67
  2. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C. … Breton S. (Mitochondrial DNA 2015) 67
  3. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C. … Cohen P. (Trends Endocrinol. Metab. 2013) 67
  4. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E. … Collodel G. (Fertil. Steril. 2010) 67
  5. Humanin: a novel central regulator of peripheral insulin action. (PMID: 19623253) Muzumdar R.H. … Cohen P. (PLoS ONE 2009) 67

Products for MTRNR2L6 Gene

Sources for MTRNR2L6 Gene

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