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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTRNR2L6 Gene

protein-coding   GIFtS: 27
GCID: GC07P142709

MT-RNR2-Like 6

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MT-RNR2-Like 61 2
HN62 3
Humanin-Like Protein 62
MTRNR2-Like 62
MT-RNR2-Like Protein 63

External Ids:    HGNC: 371631   Entrez Gene: 1004634822   Ensembl: ENSG000002706727   UniProtKB: P0CJ733   

Export aliases for MTRNR2L6 gene to outside databases

Previous GC identifers: GC07U902933 GC07P142375 GC07P142377 GC07P142393 GC07P142435 GC07P142482 GC07P142639


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MTRNR2L6 Gene: 
MTRNR2L6 (MT-RNR2-like 6) is a protein-coding gene. Diseases associated with MTRNR2L6 include alzheimer's disease, and neuronitis.

UniProtKB/Swiss-Prot: HMN6_HUMAN, P0CJ73
Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MTRNR2L6
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTRNR2L6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

MTRNR2L6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTRNR2L6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142709:  view genomic region     (about GC identifiers)

Start:
142,374,104 bp from pter      End:
142,375,550 bp from pter
Size:
1,447 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,NW_003571040 848,923-850,317      Chr7+,CRA_TCAG 141,745,424-141,746,818     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HMN6_HUMAN, P0CJ73 (See protein sequence)
Recommended Name: Humanin-like protein 6  
Size: 24 amino acids; 2719 Da
Subcellular location: Cytoplasm (By similarity). Secreted (By similarity)

Explore the universe of human proteins at neXtProt for MTRNR2L6: NX_P0CJ73

MTRNR2L6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001177416.1  
ENSEMBL proteins: 
 ENSP00000473686  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005737cytoplasm IEA--

MTRNR2L6 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: P0CJ73

UniProtKB/Swiss-Prot: HMN6_HUMAN, P0CJ73
Similarity: Belongs to the humanin family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HMN6_HUMAN, P0CJ73
Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)
Induction: Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS
treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours
following beta-carotene treatment

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTRNR2L6

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Search CenterWatch for drugs/clinical trials and news about MTRNR2L6 / HMN6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MTRNR2L6 gene: 
NM_001190487.1  

Unigene Cluster for MTRNR2L6:

MT-RNR2-like 6
Hs.727419
Unigene Representative Sequence: NM_001190487
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000604952

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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


SOURCE GeneReport for Unigene cluster: Hs.727419

UniProtKB/Swiss-Prot: HMN6_HUMAN, P0CJ73
Tissue specificity: Expressed in skeletal muscle and testis

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for MTRNR2L6 (if available)
TreeFam Gene Tree for MTRNR2L6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MTRNR2L6 gene
5 SIMAP similar genes for MTRNR2L6 using alignment to 1 protein entry:     HMN6_HUMAN:
MTRNR2L1    MT-RNR2    MTRNR2L2    MTRNR2L8    MTRNR2L9

MTRNR2L6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/105 SNPs in MTRNR2L6 are shown (see all 105)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1484538531,2
C--142372174(+) TACTAC/TGTTGA 1 -- us2k10--------
rs1844253371,2
--142372206(+) ATCTTC/TGTCTT 1 -- us2k10--------
rs1888719291,2
--142372216(+) TGTGCC/TGGTTT 1 -- us2k10--------
rs1926517571,2
--142372316(+) CAGTCA/GTGGGA 1 -- us2k10--------
rs21876331,2
C,F,A--142372329(+) ACTGCC/TGTGCA 1 -- us2k110Minor allele frequency- T:0.43WA NA CSA EA 370
rs21569641,2
C,F--142372587(+) AACACC/TCCCCT 1 -- us2k16Minor allele frequency- T:0.26WA NA EA 364
rs102318561,2
C,F,H--142372671(+) CAACTC/GTGCCA 1 -- us2k17Minor allele frequency- G:0.03NS EA NA WA 542
rs1846853811,2
--142372720(+) AACAGC/TTACCC 1 -- us2k10--------
rs102472331,2
C,F,A--142372764(+) CCCTCA/GCCAAT 1 -- us2k112Minor allele frequency- N:0.02EA NA WA CSA 583
rs1180489401,2
C,F--142372807(+) ACGCAC/TGCCCA 1 -- us2k11Minor allele frequency- T:0.03EA 120

HapMap Linkage Disequilibrium report for MTRNR2L6 (142374104 - 142375550 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for MTRNR2L6:    About this table     
Variant IDTypeSubtypePubMed ID
nsv428187CNV Loss18775914
dgv841n27CNV Loss19166990
nsv465170CNV Loss19166990
nsv824336CNV Loss20364138
esv34617CNV Loss17911159
nsv824337CNV Loss20364138
nsv8223CNV Loss18304495
nsv831166CNV Gain+Loss17160897
essv19150CNV CNV17122850
dgv2145e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for MTRNR2L6:    About MalaCards
alzheimer's disease    neuronitis


MTRNR2L6 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): MTRNR2L6

Export disorders for MTRNR2L6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MTRNR2L6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MTRNR2L6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Evidence for potential functionality of nuclearly-enc oded humanin isoforms. (PubMed id 19477263)1, 2, 3 Bodzioch M....Dembinska-Kiec A. (2009)
  2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
  3. Humanin: a harbinger of mitochondrial-derived peptides ? (PubMed id 23402768)1 Lee C....Cohen P. (2013)
  4. Immunolocalization of humanin in human sperm and test is. (PubMed id 20542501)1 Moretti E....Collodel G. (2010)
  5. Humanin: a novel central regulator of peripheral insul in action. (PubMed id 19623253)1 Muzumdar R.H....Cohen P. (2009)
  6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
  7. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PubMed id 12732850)1 Guo B....Reed J.C. (2003)
  8. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PubMed id 12009529)1 Tajima H.... Nishimoto I. (2002)
  9. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PubMed id 11371646)1 Hashimoto Y.... Nashimoto I. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100463482 HGNC: 37163 Ensembl:ENSG00000270672 euGenes: HUgn100463482 ECgene: MTRNR2L6
H-InvDB: MTRNR2L6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MTRNR2L6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MTRNR2L6 gene:
Search GeneIP for patents involving MTRNR2L6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTRNR2L6
 Browse SwitchGear 3'UTR luciferase reporter plasmids for MTRNR2L6
 Browse SwitchGear Promoter luciferase reporter plasmids for MTRNR2L6
 Search ThermoFisher Antibodies for MTRNR2L6
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MTRNR2L6
 inGenious Targeting Laboratory - Custom generated mouse model solutions for MTRNR2L6
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MTRNR2L6
Customized:
 lentivirus for stable overexpression of MTRNR2L6
 lentivirus expression plasmids for stable overexpression of MTRNR2L6
 adenovirus for overexpression of MTRNR2L6
 Search LSBio for Antibodies for MTRNR2L6
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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