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Aliases for MTRNR2L5 Gene

Aliases for MTRNR2L5 Gene

  • MT-RNR2-Like 5 2 3
  • Humanin-Like 5 2 3
  • HN5 3 4
  • Humanin-Like Protein 5 3
  • MT-RNR2-Like Protein 5 4
  • MTRNR2-Like 5 3

External Ids for MTRNR2L5 Gene

Previous GeneCards Identifiers for MTRNR2L5 Gene

  • GC10U901394
  • GC10P057360

Summaries for MTRNR2L5 Gene

GeneCards Summary for MTRNR2L5 Gene

MTRNR2L5 (MT-RNR2-Like 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L5 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L5 Gene

Genomics for MTRNR2L5 Gene

Genomic Location for MTRNR2L5 Gene

55,598,990 bp from pter
55,600,728 bp from pter
1,739 bases
Plus strand

Genomic View for MTRNR2L5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTRNR2L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L5 Gene

No data available for Regulatory Elements for MTRNR2L5 Gene

Proteins for MTRNR2L5 Gene

  • Protein details for MTRNR2L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 5
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MTRNR2L5 Gene

    24 amino acids
    Molecular mass:
    2666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L5 Gene

Proteomics data for MTRNR2L5 Gene at MOPED

Post-translational modifications for MTRNR2L5 Gene

No Post-translational modifications

Other Protein References for MTRNR2L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L5 Gene

Domains for MTRNR2L5 Gene

Protein Domains for MTRNR2L5 Gene


Suggested Antigen Peptide Sequences for MTRNR2L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L5: view

No data available for Gene Families for MTRNR2L5 Gene

Function for MTRNR2L5 Gene

Molecular function for MTRNR2L5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, remains down-regulated 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MTRNR2L5 Gene

Localization for MTRNR2L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L5 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L5: view

No data available for Subcellular locations from COMPARTMENTS for MTRNR2L5 Gene

Pathways for MTRNR2L5 Gene

SuperPathways for MTRNR2L5 Gene

No Data Available

Interacting Proteins for MTRNR2L5 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L5 Gene


No data available for Pathways by source for MTRNR2L5 Gene

Transcripts for MTRNR2L5 Gene

mRNA/cDNA for MTRNR2L5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L5 Gene

MT-RNR2-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L5 Gene

No ASD Table

Relevant External Links for MTRNR2L5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L5 Gene

mRNA expression in normal human tissues for MTRNR2L5 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L5 Gene

This gene is overexpressed in Adrenal Gland (27.6), Pituitary (14.2), Skin - Not Sun Exposed (Suprapubic) (5.6), and Brain - Cortex (5.5).

SOURCE GeneReport for Unigene cluster for MTRNR2L5 Gene Hs.727204

mRNA Expression by UniProt/SwissProt for MTRNR2L5 Gene

Tissue specificity: Expressed in testis and brain.
genes like me logo Genes that share expressions with MTRNR2L5: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for MTRNR2L5 Gene

Orthologs for MTRNR2L5 Gene

Evolution for MTRNR2L5 Gene

Gene Tree for MTRNR2L5 (if available)
Gene Tree for MTRNR2L5 (if available)

No data available for Orthologs for MTRNR2L5 Gene

Paralogs for MTRNR2L5 Gene

(5) SIMAP similar genes for MTRNR2L5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L5: view

No data available for Paralogs for MTRNR2L5 Gene

Variants for MTRNR2L5 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11004928 - 55,599,937(+) TTCAA(C/T)CAGTG reference, missense
rs578085341 -- 55,599,168(+) TCTAG(C/T)CAAGT utr-variant-5-prime
rs577669135 -- 55,597,569(+) AATTT(A/C)TGTCT upstream-variant-2KB
rs576587848 -- 55,596,998(+) GGGAG(A/G)AAATA upstream-variant-2KB
rs576437579 -- 55,597,594(+) TACTT(A/C)AAGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L5 Gene

Variant ID Type Subtype PubMed ID
nsv895480 CNV Loss 21882294
nsv895482 CNV Loss 21882294
nsv895483 CNV Loss 21882294
nsv895484 CNV Loss 21882294
nsv895485 CNV Loss 21882294
dgv723n71 CNV Loss 21882294
nsv895488 CNV Gain 21882294
nsv895489 CNV Loss 21882294

Relevant External Links for MTRNR2L5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L5 Gene

Disorders for MTRNR2L5 Gene

No disorders were found for MTRNR2L5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MTRNR2L5 Gene

Publications for MTRNR2L5 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PMID: 11371646) Hashimoto Y. … Nashimoto I. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3
  4. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PMID: 12009529) Tajima H. … Nishimoto I. (Neurosci. Lett. 2002) 3
  5. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PMID: 12732850) Guo B. … Reed J.C. (Nature 2003) 3

Products for MTRNR2L5 Gene

Sources for MTRNR2L5 Gene

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