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Aliases for MTRNR2L5 Gene

Aliases for MTRNR2L5 Gene

  • MT-RNR2-Like 5 2 3
  • HN5 3 4
  • Humanin-Like Protein 5 3
  • MT-RNR2-Like Protein 5 4
  • Humanin-Like 5 2
  • MTRNR2-Like 5 3

External Ids for MTRNR2L5 Gene

Previous GeneCards Identifiers for MTRNR2L5 Gene

  • GC10U901394
  • GC10P057360

Summaries for MTRNR2L5 Gene

GeneCards Summary for MTRNR2L5 Gene

MTRNR2L5 (MT-RNR2-Like 5) is a Protein Coding gene. Diseases associated with MTRNR2L5 include asthenopia and paralytic squint.

UniProtKB/Swiss-Prot for MTRNR2L5 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L5 Gene

Genomics for MTRNR2L5 Gene

Genomic Location for MTRNR2L5 Gene

55,598,990 bp from pter
55,600,728 bp from pter
1,739 bases
Plus strand

Genomic View for MTRNR2L5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MTRNR2L5 Gene

No data available for Regulatory Elements for MTRNR2L5 Gene

Proteins for MTRNR2L5 Gene

  • Protein details for MTRNR2L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 5
    Protein Accession:

    Protein attributes for MTRNR2L5 Gene

    24 amino acids
    Molecular mass:
    2666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L5 Gene

Proteomics data for MTRNR2L5 Gene at MOPED

Post-translational modifications for MTRNR2L5 Gene

No Post-translational modifications

Other Protein References for MTRNR2L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L5 Gene

Domains & Families for MTRNR2L5 Gene

Protein Domains for MTRNR2L5 Gene


Suggested Antigen Peptide Sequences for MTRNR2L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L5: view

No data available for Gene Families for MTRNR2L5 Gene

Function for MTRNR2L5 Gene

Molecular function for MTRNR2L5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, remains down-regulated 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L5 Gene

Localization for MTRNR2L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L5 Gene

Secreted. Cytoplasm.

Subcellular locations from

Jensen Localization Image for MTRNR2L5 Gene COMPARTMENTS Subcellular localization image for MTRNR2L5 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L5: view

Pathways & Interactions for MTRNR2L5 Gene

SuperPathways for MTRNR2L5 Gene

No Data Available

Interacting Proteins for MTRNR2L5 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L5 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L5 Gene

Drugs & Compounds for MTRNR2L5 Gene

No Compound Related Data Available

Transcripts for MTRNR2L5 Gene

mRNA/cDNA for MTRNR2L5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L5 Gene

MT-RNR2-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L5 Gene

No ASD Table

Relevant External Links for MTRNR2L5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L5 Gene

mRNA expression in normal human tissues for MTRNR2L5 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L5 Gene

This gene is overexpressed in Adrenal Gland (x27.6), Pituitary (x14.2), Skin - Not Sun Exposed (Suprapubic) (x5.6), and Brain - Cortex (x5.5).

SOURCE GeneReport for Unigene cluster for MTRNR2L5 Gene Hs.727204

mRNA Expression by UniProt/SwissProt for MTRNR2L5 Gene

Tissue specificity: Expressed in testis and brain.
genes like me logo Genes that share expression patterns with MTRNR2L5: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MTRNR2L5 Gene

Orthologs for MTRNR2L5 Gene

Evolution for MTRNR2L5 Gene

Gene Tree for MTRNR2L5 (if available)
Gene Tree for MTRNR2L5 (if available)

No data available for Orthologs for MTRNR2L5 Gene

Paralogs for MTRNR2L5 Gene

(5) SIMAP similar genes for MTRNR2L5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L5: view

No data available for Paralogs for MTRNR2L5 Gene

Variants for MTRNR2L5 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4290137 -- 55,600,319(+) AGATG(G/T)TGCCA utr-variant-3-prime
rs4363502 -- 55,598,904(+) TTACA(A/C)CCGGA upstream-variant-2KB
rs4394744 -- 55,599,036(+) ACTTA(C/T)TCTGG utr-variant-5-prime
rs4612709 -- 55,598,907(+) CACCC(A/G)GAAGA upstream-variant-2KB
rs5785147 -- 55,598,331(+) TGCTT(-/AGCCCTAA)ACACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L5 Gene

Variant ID Type Subtype PubMed ID
nsv895480 CNV Loss 21882294
nsv895482 CNV Loss 21882294
nsv895483 CNV Loss 21882294
nsv895484 CNV Loss 21882294
nsv895485 CNV Loss 21882294
dgv723n71 CNV Loss 21882294
nsv895488 CNV Gain 21882294
nsv895489 CNV Loss 21882294

Variation tolerance for MTRNR2L5 Gene

Gene Damage Index Score: 7.44; 81.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTRNR2L5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L5 Gene

Disorders for MTRNR2L5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MTRNR2L5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • accommodative asthenopia
paralytic squint
  • incomitant dissociation
premenstrual tension
  • premenstrual syndrome
facial nerve disease
  • facial nerve diseases
facial paralysis
  • facial palsy
- elite association

Relevant External Links for MTRNR2L5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MTRNR2L5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTRNR2L5 Gene

Publications for MTRNR2L5 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 67
  2. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C. … Breton S. (Mitochondrial DNA 2015) 67
  3. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C. … Cohen P. (Trends Endocrinol. Metab. 2013) 67
  4. Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. (PMID: 23726511) Xie P. … Gelernter J. (Biol. Psychiatry 2013) 67
  5. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E. … Collodel G. (Fertil. Steril. 2010) 67

Products for MTRNR2L5 Gene

Sources for MTRNR2L5 Gene

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