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Aliases for MTRNR2L5 Gene

Aliases for MTRNR2L5 Gene

  • MT-RNR2-Like 5 2 3 5
  • Humanin-Like 5 2 3
  • HN5 3 4
  • Humanin-Like Protein 5 3
  • MT-RNR2-Like Protein 5 4
  • MTRNR2-Like 5 3

External Ids for MTRNR2L5 Gene

Previous GeneCards Identifiers for MTRNR2L5 Gene

  • GC10U901394
  • GC10P057360

Summaries for MTRNR2L5 Gene

GeneCards Summary for MTRNR2L5 Gene

MTRNR2L5 (MT-RNR2-Like 5) is a Protein Coding gene. Diseases associated with MTRNR2L5 include Asthenopia and Ametropic Amblyopia. An important paralog of this gene is MTRNR2L8.

UniProtKB/Swiss-Prot for MTRNR2L5 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

Additional gene information for MTRNR2L5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L5 Gene

Genomics for MTRNR2L5 Gene

GeneHancer (GH) Regulatory Elements for MTRNR2L5 Gene

Promoters and enhancers for MTRNR2L5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I055599 Promoter 0.5 EPDnew 550.8 +0.4 438 0.1 MTRNR2L5 PCDH15
GH10I055600 Promoter 0.5 EPDnew 550.8 +0.2 204 0.1 ENSG00000236744 MTRNR2L5 PCDH15
GH10I055602 Enhancer 0.2 Ensembl 0.8 +3.2 3211 0.4 MTRNR2L5 PCDH15
GH10I055627 Enhancer 0.3 ENCODE 0.3 +28.6 28641 0.6 EZH2 PCDH15 MTRNR2L5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTRNR2L5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTRNR2L5 Gene

Genomic Locations for MTRNR2L5 Gene
1,739 bases
Plus strand

Genomic View for MTRNR2L5 Gene

Genes around MTRNR2L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L5 Gene

Proteins for MTRNR2L5 Gene

  • Protein details for MTRNR2L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 5
    Protein Accession:

    Protein attributes for MTRNR2L5 Gene

    24 amino acids
    Molecular mass:
    2666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L5 Gene

Post-translational modifications for MTRNR2L5 Gene

No Post-translational modifications

Other Protein References for MTRNR2L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L5 Gene

Domains & Families for MTRNR2L5 Gene

Gene Families for MTRNR2L5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTRNR2L5 Gene


Suggested Antigen Peptide Sequences for MTRNR2L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L5: view

Function for MTRNR2L5 Gene

Molecular function for MTRNR2L5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, remains down-regulated 24 hours following beta-carotene treatment.

Phenotypes From GWAS Catalog for MTRNR2L5 Gene

Gene Ontology (GO) - Molecular Function for MTRNR2L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MTRNR2L5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L5 Gene

Localization for MTRNR2L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L5 Gene

Secreted. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L5 gene
Compartment Confidence
extracellular 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MTRNR2L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MTRNR2L5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L5 Gene

Pathways & Interactions for MTRNR2L5 Gene

SuperPathways for MTRNR2L5 Gene

No Data Available

Interacting Proteins for MTRNR2L5 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072734 cellular response to staurosporine IMP 19477263
GO:1900118 negative regulation of execution phase of apoptosis IMP 19477263
GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process IMP 19477263
genes like me logo Genes that share ontologies with MTRNR2L5: view

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L5 Gene

Drugs & Compounds for MTRNR2L5 Gene

No Compound Related Data Available

Transcripts for MTRNR2L5 Gene

mRNA/cDNA for MTRNR2L5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L5 Gene

MT-RNR2-like 5:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L5 Gene

No ASD Table

Relevant External Links for MTRNR2L5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L5 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L5 Gene

This gene is overexpressed in Adrenal Gland (x27.6), Pituitary (x14.2), Skin - Not Sun Exposed (Suprapubic) (x5.6), and Brain - Cortex (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L5 Gene:


SOURCE GeneReport for Unigene cluster for MTRNR2L5 Gene:


mRNA Expression by UniProt/SwissProt for MTRNR2L5 Gene:

Tissue specificity: Expressed in testis and brain.
genes like me logo Genes that share expression patterns with MTRNR2L5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L5 Gene

Orthologs for MTRNR2L5 Gene

Evolution for MTRNR2L5 Gene

Gene Tree for MTRNR2L5 (if available)
Gene Tree for MTRNR2L5 (if available)

No data available for Orthologs for MTRNR2L5 Gene

Paralogs for MTRNR2L5 Gene

Paralogs for MTRNR2L5 Gene

(5) SIMAP similar genes for MTRNR2L5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L5: view

Variants for MTRNR2L5 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L5 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000670879 -- 55,600,478(+) A/G 3_prime_UTR_variant
rs1000845573 -- 55,598,270(+) TTT/TT upstream_transcript_variant
rs1001338407 -- 55,600,641(+) T/C 3_prime_UTR_variant
rs1001528633 -- 55,598,751(+) CCC/CC upstream_transcript_variant
rs1002636502 -- 55,600,249(+) A/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L5 Gene

Variant ID Type Subtype PubMed ID
dgv864n100 CNV gain 25217958
esv2761598 CNV loss 21179565
esv3623350 CNV loss 21293372
nsv1041917 CNV loss 25217958
nsv1048800 CNV gain 25217958
nsv1053015 CNV gain 25217958
nsv551044 CNV loss 21841781
nsv551045 CNV loss 21841781
nsv551049 CNV loss 21841781
nsv948018 CNV duplication 23825009
nsv975063 CNV duplication 23825009

Variation tolerance for MTRNR2L5 Gene

Gene Damage Index Score: 7.44; 81.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTRNR2L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L5 Gene

Disorders for MTRNR2L5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MTRNR2L5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • accommodative strain
ametropic amblyopia
  • refractive amblyopia
paralytic squint
  • incomitant dissociation
premenstrual tension
  • premenstrual syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MTRNR2L5

genes like me logo Genes that share disorders with MTRNR2L5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTRNR2L5 Gene

Publications for MTRNR2L5 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C … Breton S (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2016) 3 58
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C … Cohen P (Trends in endocrinology and metabolism: TEM 2013) 3 58
  5. Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. (PMID: 23726511) Xie P … Gelernter J (Biological psychiatry 2013) 3 58

Products for MTRNR2L5 Gene

Sources for MTRNR2L5 Gene

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