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Aliases for MTRNR2L4 Gene

Aliases for MTRNR2L4 Gene

  • MT-RNR2-Like 4 2 3 5
  • Humanin-Like 4 2 3
  • HN4 3 4
  • Humanin-Like Protein 4 3
  • MT-RNR2-Like Protein 4 4
  • MTRNR2-Like 4 3

External Ids for MTRNR2L4 Gene

Previous GeneCards Identifiers for MTRNR2L4 Gene

  • GC16U901199
  • GC16M003429
  • GC16M003435
  • GC16M003439
  • GC16M003444
  • GC16M003450
  • GC16M003454
  • GC16M003458
  • GC16M003463

Summaries for MTRNR2L4 Gene

GeneCards Summary for MTRNR2L4 Gene

MTRNR2L4 (MT-RNR2-Like 4) is a Protein Coding gene. Diseases associated with MTRNR2L4 include Third Cranial Nerve Disease and Asthenopia. An important paralog of this gene is MTRNR2L5.

UniProtKB/Swiss-Prot for MTRNR2L4 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L4 Gene

Genomics for MTRNR2L4 Gene

Regulatory Elements for MTRNR2L4 Gene

Enhancers for MTRNR2L4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G003156 1.7 FANTOM5 ENCODE dbSUPER 18.2 +213.9 213947 3.8 CREB3L1 DMAP1 YY1 ZNF263 SP3 NFYC TBX21 MEF2D SSRP1 ZNF610 ZNF213-AS1 ZNF205 CLUAP1 RNPS1 MTCO1P28 ZNF174 ZNF263 MTND1P8 TIGD7 MTRNR2L4
GH16G003019 1.4 ENCODE dbSUPER 17.7 +350.4 350438 5.2 MLX CREB3L1 AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 SP3 BICDL2 ZNF174 ZNF205 TIGD7 ZNF597 MTRNR2L4 CLUAP1 ZNF263 SNHG19 ERVK13-1
GH16G002602 2.4 ENCODE dbSUPER 9.7 +769.1 769124 1.7 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 TIGD7 NME3 CLUAP1 TBC1D24 ZNF213-AS1 MTCO1P28 ZNF597 ZNF174 MTND1P8 IFT140
GH16G003069 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +298.4 298361 9.8 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A YBX1 ZNF2 ZBTB7B ZNF205 LOC105371058 MMP25 IL32 FLYWCH2 BICDL2 LOC100128770 THOC6 HCFC1R1 CLDN6
GH16G002719 1.1 ENCODE 18.4 +652.1 652115 2.6 HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 ZNF263 TIGD7 MTND1P8 MTRNR2L4 FLYWCH2 NME3 CLUAP1 ZNF213-AS1 MTCO1P28 ZNF174 RNPS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTRNR2L4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTRNR2L4 Gene

Chromosome:
16
Start:
3,370,979 bp from pter
End:
3,372,740 bp from pter
Size:
1,762 bases
Orientation:
Minus strand

Genomic View for MTRNR2L4 Gene

Genes around MTRNR2L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L4 Gene

Proteins for MTRNR2L4 Gene

  • Protein details for MTRNR2L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ71-HMN4_HUMAN
    Recommended name:
    Humanin-like 4
    Protein Accession:
    P0CJ71

    Protein attributes for MTRNR2L4 Gene

    Size:
    28 amino acids
    Molecular mass:
    3247 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L4 Gene

Post-translational modifications for MTRNR2L4 Gene

No Post-translational modifications

Other Protein References for MTRNR2L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L4 Gene

Domains & Families for MTRNR2L4 Gene

Protein Domains for MTRNR2L4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ71

UniProtKB/Swiss-Prot:

HMN4_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L4: view

No data available for Gene Families for MTRNR2L4 Gene

Function for MTRNR2L4 Gene

Molecular function for MTRNR2L4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Expression is not affected following staurosporine (STS) treatment. Down-regulated 6 hours following beta-carotene treatment, remains down-regulated 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L4 Gene

Localization for MTRNR2L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L4 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L4 gene
Compartment Confidence
extracellular 4
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MTRNR2L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L4: view

Pathways & Interactions for MTRNR2L4 Gene

SuperPathways for MTRNR2L4 Gene

No Data Available

Interacting Proteins for MTRNR2L4 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L4 Gene

Transcripts for MTRNR2L4 Gene

mRNA/cDNA for MTRNR2L4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L4 Gene

MT-RNR2-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L4 Gene

No ASD Table

Relevant External Links for MTRNR2L4 Gene

GeneLoc Exon Structure for
MTRNR2L4
ECgene alternative splicing isoforms for
MTRNR2L4

Expression for MTRNR2L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L4 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L4 Gene

This gene is overexpressed in Ovary (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L4 Gene:

MTRNR2L4

SOURCE GeneReport for Unigene cluster for MTRNR2L4 Gene:

Hs.639648

mRNA Expression by UniProt/SwissProt for MTRNR2L4 Gene:

P0CJ71-HMN4_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain.
genes like me logo Genes that share expression patterns with MTRNR2L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L4 Gene

Orthologs for MTRNR2L4 Gene

Evolution for MTRNR2L4 Gene

ENSEMBL:
Gene Tree for MTRNR2L4 (if available)
TreeFam:
Gene Tree for MTRNR2L4 (if available)

No data available for Orthologs for MTRNR2L4 Gene

Paralogs for MTRNR2L4 Gene

Paralogs for MTRNR2L4 Gene

(2) SIMAP similar genes for MTRNR2L4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L4: view

Variants for MTRNR2L4 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000154674 -- 3,371,576(+) CCACA(C/G)CCAGC intron-variant, utr-variant-3-prime
rs1001331142 -- 3,371,863(+) TTCAC(C/T)GACTG intron-variant, reference, missense
rs1001615442 -- 3,371,644(+) ATCTC(C/T)TGACC intron-variant, utr-variant-3-prime
rs1001891657 -- 3,372,689(+) GTAAT(A/T)TTTTT intron-variant, upstream-variant-2KB
rs1003067623 -- 3,371,702(+) TGAGC(C/T)ACCAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L4 Gene

Variant ID Type Subtype PubMed ID
dgv2694n100 CNV gain 25217958
dgv2695n100 CNV gain 25217958
dgv476e199 CNV deletion 23128226
esv3637664 CNV loss 21293372
nsv1044147 CNV loss 25217958
nsv1054969 CNV loss 25217958
nsv1714 CNV insertion 18451855
nsv974749 CNV duplication 23825009

Relevant External Links for MTRNR2L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTRNR2L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MTRNR2L4 Gene

Disorders for MTRNR2L4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MTRNR2L4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
third cranial nerve disease
  • oculomotor nerve paralysis
asthenopia
  • accommodative strain
oculomotor nerve paralysis
  • iii nerve palsy
cranial nerve disease
  • cranial nerve disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MTRNR2L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTRNR2L4
genes like me logo Genes that share disorders with MTRNR2L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTRNR2L4 Gene

Publications for MTRNR2L4 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4 64
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C. … Breton S. (Mitochondrial DNA 2015) 3 64
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C. … Cohen P. (Trends Endocrinol. Metab. 2013) 3 64
  5. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E. … Collodel G. (Fertil. Steril. 2010) 3 64

Products for MTRNR2L4 Gene

Sources for MTRNR2L4 Gene

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