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Aliases for MTRNR2L4 Gene

Aliases for MTRNR2L4 Gene

  • MT-RNR2-Like 4 2 3
  • Humanin-Like 4 2 3
  • HN4 3 4
  • Humanin-Like Protein 4 3
  • MT-RNR2-Like Protein 4 4
  • MTRNR2-Like 4 3

External Ids for MTRNR2L4 Gene

Previous GeneCards Identifiers for MTRNR2L4 Gene

  • GC16U901199
  • GC16M003429
  • GC16M003435
  • GC16M003439
  • GC16M003444
  • GC16M003450
  • GC16M003454
  • GC16M003458
  • GC16M003463

Summaries for MTRNR2L4 Gene

GeneCards Summary for MTRNR2L4 Gene

MTRNR2L4 (MT-RNR2-Like 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L4 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L4 Gene

Genomics for MTRNR2L4 Gene

Genomic Location for MTRNR2L4 Gene

Start:
3,370,979 bp from pter
End:
3,372,740 bp from pter
Size:
1,762 bases
Orientation:
Minus strand

Genomic View for MTRNR2L4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTRNR2L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L4 Gene

No data available for Regulatory Elements for MTRNR2L4 Gene

Proteins for MTRNR2L4 Gene

  • Protein details for MTRNR2L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ71-HMN4_HUMAN
    Recommended name:
    Humanin-like 4
    Protein Accession:
    P0CJ71
    Secondary Accessions:

    Protein attributes for MTRNR2L4 Gene

    Size:
    28 amino acids
    Molecular mass:
    3247 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L4 Gene

Proteomics data for MTRNR2L4 Gene at MOPED

Post-translational modifications for MTRNR2L4 Gene

No Post-translational modifications

Other Protein References for MTRNR2L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L4 Gene

Domains for MTRNR2L4 Gene

Protein Domains for MTRNR2L4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ71

UniProtKB/Swiss-Prot:

HMN4_HUMAN :
  • P0CJ71
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L4: view

No data available for Gene Families for MTRNR2L4 Gene

Function for MTRNR2L4 Gene

Molecular function for MTRNR2L4 Gene

UniProtKB/Swiss-Prot Function: Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction: Expression is not affected following staurosporine (STS) treatment. Down-regulated 6 hours following beta-carotene treatment, remains down-regulated 24 hours following beta-carotene treatment.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MTRNR2L4 Gene

Localization for MTRNR2L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L4 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L4: view

No data available for Subcellular locations from COMPARTMENTS for MTRNR2L4 Gene

Pathways for MTRNR2L4 Gene

SuperPathways for MTRNR2L4 Gene

No Data Available

Interacting Proteins for MTRNR2L4 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L4 Gene

None

No data available for Pathways by source for MTRNR2L4 Gene

Transcripts for MTRNR2L4 Gene

mRNA/cDNA for MTRNR2L4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L4 Gene

MT-RNR2-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L4 Gene

No ASD Table

Relevant External Links for MTRNR2L4 Gene

GeneLoc Exon Structure for
MTRNR2L4
ECgene alternative splicing isoforms for
MTRNR2L4

Expression for MTRNR2L4 Gene

mRNA expression in normal human tissues for MTRNR2L4 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L4 Gene

This gene is overexpressed in Ovary (5.4).

SOURCE GeneReport for Unigene cluster for MTRNR2L4 Gene Hs.639648

mRNA Expression by UniProt/SwissProt for MTRNR2L4 Gene

P0CJ71-HMN4_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain.
genes like me logo Genes that share expressions with MTRNR2L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for MTRNR2L4 Gene

Orthologs for MTRNR2L4 Gene

Evolution for MTRNR2L4 Gene

ENSEMBL:
Gene Tree for MTRNR2L4 (if available)
TreeFam:
Gene Tree for MTRNR2L4 (if available)

No data available for Orthologs for MTRNR2L4 Gene

Paralogs for MTRNR2L4 Gene

Selected SIMAP similar genes for MTRNR2L4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L4: view

No data available for Paralogs for MTRNR2L4 Gene

Variants for MTRNR2L4 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs37799 -- 3,372,604(+) aagtg(C/G)tggga upstream-variant-2KB
rs37800 -- 3,373,648(+) acgtg(G/T)tattt upstream-variant-2KB
rs7195948 -- 3,372,598(+) CTCCC(A/G)AAGTG upstream-variant-2KB
rs7204929 -- 3,372,399(+) agtga(C/T)gcaat upstream-variant-2KB
rs8053830 -- 3,371,691(+) GATTA(C/T)AGGCG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L4 Gene

Variant ID Type Subtype PubMed ID
nsv905212 CNV Gain 21882294
nsv1714 CNV Insertion 18451855
dgv476e199 CNV Deletion 23128226

Relevant External Links for MTRNR2L4 Gene

HapMap Linkage Disequilibrium report
MTRNR2L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L4 Gene

Disorders for MTRNR2L4 Gene

No disorders were found for MTRNR2L4 Gene.

No data available for UniProtKB/Swiss-Prot for MTRNR2L4 Gene

Publications for MTRNR2L4 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  3. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PMID: 11371646) Hashimoto Y. … Nashimoto I. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3
  4. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PMID: 12009529) Tajima H. … Nishimoto I. (Neurosci. Lett. 2002) 3
  5. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PMID: 12732850) Guo B. … Reed J.C. (Nature 2003) 3

Products for MTRNR2L4 Gene

Sources for MTRNR2L4 Gene

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