Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTRNR2L2 Gene

Aliases for MTRNR2L2 Gene

  • MT-RNR2-Like 2 2 3
  • Humanin-Like 2 2 3
  • HN2 3 4
  • Humanin-Like Protein 2 3
  • MT-RNR2-Like Protein 2 4
  • MTRNR2-Like 2 3

External Ids for MTRNR2L2 Gene

Previous GeneCards Identifiers for MTRNR2L2 Gene

  • GC05U901448
  • GC05M075154
  • GC05M079945

Summaries for MTRNR2L2 Gene

GeneCards Summary for MTRNR2L2 Gene

MTRNR2L2 (MT-RNR2-Like 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L2 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L2 Gene

Genomics for MTRNR2L2 Gene

Genomic Location for MTRNR2L2 Gene

Start:
80,650,000 bp from pter
End:
80,651,035 bp from pter
Size:
1,036 bases
Orientation:
Minus strand

Genomic View for MTRNR2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTRNR2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L2 Gene

No data available for Regulatory Elements for MTRNR2L2 Gene

Proteins for MTRNR2L2 Gene

  • Protein details for MTRNR2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ69-HMN2_HUMAN
    Recommended name:
    Humanin-like 2
    Protein Accession:
    P0CJ69
    Secondary Accessions:

    Protein attributes for MTRNR2L2 Gene

    Size:
    28 amino acids
    Molecular mass:
    3081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L2 Gene

Proteomics data for MTRNR2L2 Gene at MOPED

Post-translational modifications for MTRNR2L2 Gene

No Post-translational modifications

Other Protein References for MTRNR2L2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L2 Gene

Domains for MTRNR2L2 Gene

Protein Domains for MTRNR2L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ69

UniProtKB/Swiss-Prot:

HMN2_HUMAN :
  • P0CJ69
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L2: view

No data available for Gene Families for MTRNR2L2 Gene

Function for MTRNR2L2 Gene

Molecular function for MTRNR2L2 Gene

UniProtKB/Swiss-Prot Function: Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction: Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Up-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MTRNR2L2 Gene

Localization for MTRNR2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L2 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L2: view

No data available for Subcellular locations from COMPARTMENTS for MTRNR2L2 Gene

Pathways for MTRNR2L2 Gene

SuperPathways for MTRNR2L2 Gene

No Data Available

Interacting Proteins for MTRNR2L2 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L2 Gene

None

No data available for Pathways by source for MTRNR2L2 Gene

Transcripts for MTRNR2L2 Gene

mRNA/cDNA for MTRNR2L2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L2 Gene

MT-RNR2-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTRNR2L2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L2 Gene

No ASD Table

Relevant External Links for MTRNR2L2 Gene

GeneLoc Exon Structure for
MTRNR2L2
ECgene alternative splicing isoforms for
MTRNR2L2

Expression for MTRNR2L2 Gene

mRNA expression in normal human tissues for MTRNR2L2 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L2 Gene

This gene is overexpressed in Brain - Amygdala (7.3), Brain - Putamen (basal ganglia) (5.9), Brain - Anterior cingulate cortex (BA24) (5.1), and Brain - Substantia nigra (4.0).

SOURCE GeneReport for Unigene cluster for MTRNR2L2 Gene Hs.666077

mRNA Expression by UniProt/SwissProt for MTRNR2L2 Gene

P0CJ69-HMN2_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain.
genes like me logo Genes that share expressions with MTRNR2L2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for MTRNR2L2 Gene

Orthologs for MTRNR2L2 Gene

Evolution for MTRNR2L2 Gene

ENSEMBL:
Gene Tree for MTRNR2L2 (if available)
TreeFam:
Gene Tree for MTRNR2L2 (if available)

No data available for Orthologs for MTRNR2L2 Gene

Paralogs for MTRNR2L2 Gene

Selected SIMAP similar genes for MTRNR2L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L2: view

No data available for Paralogs for MTRNR2L2 Gene

Variants for MTRNR2L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L2 Gene

Variant ID Type Subtype PubMed ID
nsv483112 CNV Loss 15286789
nsv10709 CNV Loss 18304495
esv23281 CNV Gain+Loss 19812545

Relevant External Links for MTRNR2L2 Gene

HapMap Linkage Disequilibrium report
MTRNR2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MTRNR2L2 Gene

Disorders for MTRNR2L2 Gene

Relevant External Links for MTRNR2L2

Genetic Association Database (GAD)
MTRNR2L2
genes like me logo Genes that share disorders with MTRNR2L2: view

No data available for UniProtKB/Swiss-Prot for MTRNR2L2 Gene

Publications for MTRNR2L2 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4
  3. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PMID: 11371646) Hashimoto Y. … Nashimoto I. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3
  4. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PMID: 12009529) Tajima H. … Nishimoto I. (Neurosci. Lett. 2002) 3
  5. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PMID: 12732850) Guo B. … Reed J.C. (Nature 2003) 3

Products for MTRNR2L2 Gene

Sources for MTRNR2L2 Gene

Back to Top

Content