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Aliases for MTRNR2L2 Gene

Aliases for MTRNR2L2 Gene

  • MT-RNR2-Like 2 2 3 5
  • Humanin-Like 2 2 3
  • HN2 3 4
  • Humanin-Like Protein 2 3
  • MT-RNR2-Like Protein 2 4
  • MTRNR2-Like 2 3

External Ids for MTRNR2L2 Gene

Previous GeneCards Identifiers for MTRNR2L2 Gene

  • GC05U901448
  • GC05M075154
  • GC05M079945

Summaries for MTRNR2L2 Gene

GeneCards Summary for MTRNR2L2 Gene

MTRNR2L2 (MT-RNR2-Like 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L2 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L2 Gene

Genomics for MTRNR2L2 Gene

Regulatory Elements for MTRNR2L2 Gene

Enhancers for MTRNR2L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G080651 0.2 ENCODE 0.7 -0.2 -202 0.2 MTRNR2L2 GC05P080651
GH05G080652 0.2 ENCODE 0.7 -0.4 -362 0.2 DHFR GC05P080651 MTRNR2L2
GH05G080650 0.2 ENCODE 0.7 +0.3 259 0.3 MTRNR2L2 ENSG00000249655
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTRNR2L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTRNR2L2 Gene

Chromosome:
5
Start:
80,650,000 bp from pter
End:
80,651,035 bp from pter
Size:
1,036 bases
Orientation:
Minus strand

Genomic View for MTRNR2L2 Gene

Genes around MTRNR2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L2 Gene

Proteins for MTRNR2L2 Gene

  • Protein details for MTRNR2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ69-HMN2_HUMAN
    Recommended name:
    Humanin-like 2
    Protein Accession:
    P0CJ69

    Protein attributes for MTRNR2L2 Gene

    Size:
    28 amino acids
    Molecular mass:
    3081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L2 Gene

Post-translational modifications for MTRNR2L2 Gene

No Post-translational modifications

Other Protein References for MTRNR2L2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L2 Gene

Domains & Families for MTRNR2L2 Gene

Protein Domains for MTRNR2L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ69

UniProtKB/Swiss-Prot:

HMN2_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L2: view

No data available for Gene Families for MTRNR2L2 Gene

Function for MTRNR2L2 Gene

Molecular function for MTRNR2L2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Up-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L2 Gene

Localization for MTRNR2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L2 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L2: view

Pathways & Interactions for MTRNR2L2 Gene

SuperPathways for MTRNR2L2 Gene

No Data Available

Interacting Proteins for MTRNR2L2 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L2 Gene

Transcripts for MTRNR2L2 Gene

mRNA/cDNA for MTRNR2L2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L2 Gene

MT-RNR2-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L2 Gene

No ASD Table

Relevant External Links for MTRNR2L2 Gene

GeneLoc Exon Structure for
MTRNR2L2
ECgene alternative splicing isoforms for
MTRNR2L2

Expression for MTRNR2L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L2 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L2 Gene

This gene is overexpressed in Brain - Amygdala (x7.3), Brain - Putamen (basal ganglia) (x5.9), Brain - Anterior cingulate cortex (BA24) (x5.1), and Brain - Substantia nigra (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L2 Gene:

MTRNR2L2

SOURCE GeneReport for Unigene cluster for MTRNR2L2 Gene:

Hs.666077

mRNA Expression by UniProt/SwissProt for MTRNR2L2 Gene:

P0CJ69-HMN2_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain.
genes like me logo Genes that share expression patterns with MTRNR2L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L2 Gene

Orthologs for MTRNR2L2 Gene

Evolution for MTRNR2L2 Gene

ENSEMBL:
Gene Tree for MTRNR2L2 (if available)
TreeFam:
Gene Tree for MTRNR2L2 (if available)

No data available for Orthologs for MTRNR2L2 Gene

Paralogs for MTRNR2L2 Gene

(5) SIMAP similar genes for MTRNR2L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L2: view

No data available for Paralogs for MTRNR2L2 Gene

Variants for MTRNR2L2 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000156862 -- 80,652,305(+) CAAAA(C/G)ATGAA intron-variant, upstream-variant-2KB
rs1001341936 -- 80,650,152(+) GCGGC(C/T)GTTAA intron-variant, utr-variant-5-prime
rs1003162519 -- 80,651,802(+) CTTGG(A/G)TTAAT intron-variant, upstream-variant-2KB
rs1003214871 -- 80,651,954(+) TGCGT(A/G)CTTGA intron-variant, upstream-variant-2KB
rs1004585411 -- 80,652,636(+) GCAGG(C/T)GTCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L2 Gene

Variant ID Type Subtype PubMed ID
esv23281 CNV gain+loss 19812545
esv3605581 CNV gain 21293372
nsv10709 CNV loss 18304495
nsv483112 CNV loss 15286789
nsv964903 CNV duplication 23825009

Variation tolerance for MTRNR2L2 Gene

Gene Damage Index Score: 0.75; 15.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTRNR2L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTRNR2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L2 Gene

Disorders for MTRNR2L2 Gene

Relevant External Links for MTRNR2L2

Genetic Association Database (GAD)
MTRNR2L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTRNR2L2

No disorders were found for MTRNR2L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L2 Gene

Publications for MTRNR2L2 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C. … Breton S. (Mitochondrial DNA 2015) 3 64
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C. … Cohen P. (Trends Endocrinol. Metab. 2013) 3 64
  5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 46 64

Products for MTRNR2L2 Gene

Sources for MTRNR2L2 Gene

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