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Aliases for MTRNR2L2 Gene

Aliases for MTRNR2L2 Gene

  • MT-RNR2-Like 2 2 3 5
  • Humanin-Like 2 2 3
  • HN2 3 4
  • Humanin-Like Protein 2 3
  • MT-RNR2-Like Protein 2 4
  • MTRNR2-Like 2 3

External Ids for MTRNR2L2 Gene

Previous GeneCards Identifiers for MTRNR2L2 Gene

  • GC05U901448
  • GC05M075154
  • GC05M079945

Summaries for MTRNR2L2 Gene

GeneCards Summary for MTRNR2L2 Gene

MTRNR2L2 (MT-RNR2-Like 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTRNR2L2 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

Additional gene information for MTRNR2L2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L2 Gene

Genomics for MTRNR2L2 Gene

Regulatory Elements for MTRNR2L2 Gene

Enhancers for MTRNR2L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H080651 0.2 ENCODE 0.7 -0.2 -202 0.2 GC05P080651 MTRNR2L2
GH05H080652 0.2 ENCODE 0.7 -0.4 -362 0.2 DHFR GC05P080651 MTRNR2L2
GH05H080650 0.2 ENCODE 0.7 +0.3 259 0.3 MTRNR2L2 ENSG00000249655
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTRNR2L2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTRNR2L2 Gene

Genomic Locations for MTRNR2L2 Gene
1,036 bases
Minus strand

Genomic View for MTRNR2L2 Gene

Genes around MTRNR2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L2 Gene

Proteins for MTRNR2L2 Gene

  • Protein details for MTRNR2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 2
    Protein Accession:

    Protein attributes for MTRNR2L2 Gene

    28 amino acids
    Molecular mass:
    3081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L2 Gene

Post-translational modifications for MTRNR2L2 Gene

No Post-translational modifications

Other Protein References for MTRNR2L2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L2 Gene

Domains & Families for MTRNR2L2 Gene

Protein Domains for MTRNR2L2 Gene


Suggested Antigen Peptide Sequences for MTRNR2L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L2: view

No data available for Gene Families for MTRNR2L2 Gene

Function for MTRNR2L2 Gene

Molecular function for MTRNR2L2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Up-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L2 Gene

Localization for MTRNR2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L2 Gene

Secreted. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L2 Gene

Pathways & Interactions for MTRNR2L2 Gene

SuperPathways for MTRNR2L2 Gene

No Data Available

Interacting Proteins for MTRNR2L2 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L2 Gene

Drugs & Compounds for MTRNR2L2 Gene

No Compound Related Data Available

Transcripts for MTRNR2L2 Gene

mRNA/cDNA for MTRNR2L2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L2 Gene

MT-RNR2-like 2:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L2 Gene

No ASD Table

Relevant External Links for MTRNR2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L2 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L2 Gene

This gene is overexpressed in Brain - Amygdala (x7.3), Brain - Putamen (basal ganglia) (x5.9), Brain - Anterior cingulate cortex (BA24) (x5.1), and Brain - Substantia nigra (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L2 Gene:


SOURCE GeneReport for Unigene cluster for MTRNR2L2 Gene:


mRNA Expression by UniProt/SwissProt for MTRNR2L2 Gene:

Tissue specificity: Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain.
genes like me logo Genes that share expression patterns with MTRNR2L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L2 Gene

Orthologs for MTRNR2L2 Gene

Evolution for MTRNR2L2 Gene

Gene Tree for MTRNR2L2 (if available)
Gene Tree for MTRNR2L2 (if available)

No data available for Orthologs for MTRNR2L2 Gene

Paralogs for MTRNR2L2 Gene

(5) SIMAP similar genes for MTRNR2L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L2: view

No data available for Paralogs for MTRNR2L2 Gene

Variants for MTRNR2L2 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000156862 -- 80,652,305(+) CAAAA(C/G)ATGAA intron-variant, upstream-variant-2KB
rs1001341936 -- 80,650,152(+) GCGGC(C/T)GTTAA intron-variant, utr-variant-5-prime
rs1003162519 -- 80,651,802(+) CTTGG(A/G)TTAAT intron-variant, upstream-variant-2KB
rs1003214871 -- 80,651,954(+) TGCGT(A/G)CTTGA intron-variant, upstream-variant-2KB
rs1004585411 -- 80,652,636(+) GCAGG(C/T)GTCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L2 Gene

Variant ID Type Subtype PubMed ID
nsv964903 CNV duplication 23825009
nsv483112 CNV loss 15286789
nsv10709 CNV loss 18304495
esv3605581 CNV gain 21293372
esv23281 CNV gain+loss 19812545

Variation tolerance for MTRNR2L2 Gene

Gene Damage Index Score: 0.75; 15.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTRNR2L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L2 Gene

Disorders for MTRNR2L2 Gene

Relevant External Links for MTRNR2L2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MTRNR2L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L2 Gene

Publications for MTRNR2L2 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 60
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C … Breton S (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2016) 3 60
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C … Cohen P (Trends in endocrinology and metabolism: TEM 2013) 3 60
  5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin EJ … Vasan RS (BMC medical genetics 2007) 45 60

Products for MTRNR2L2 Gene

Sources for MTRNR2L2 Gene

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