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MTRNR2L2 Gene

protein-coding   GIFtS: 23
GCID: GC05M079945

MT-RNR2-Like 2

  See MTRNR2L2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MT-RNR2-Like 21 2
Humanin-Like 21 2
HN22 3
Humanin-Like Protein 22
MTRNR2-Like 22
MT-RNR2-Like Protein 23

External Ids:    HGNC: 371561   Entrez Gene: 1004629812   Ensembl: ENSG000002710437   UniProtKB: P0CJ693   

Export aliases for MTRNR2L2 gene to outside databases

Previous GC identifers: GC05U901448 GC05M075154


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTRNR2L2 Gene:
MTRNR2L2 (MT-RNR2-like 2) is a protein-coding gene. Diseases associated with MTRNR2L2 include alzheimer's disease.

UniProtKB/Swiss-Prot: HMN2_HUMAN, P0CJ69
Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MTRNR2L2
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTRNR2L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.1   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

MTRNR2L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTRNR2L2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M079945:  view genomic region     (about GC identifiers)

Start:
79,945,819 bp from pter      End:
79,946,855 bp from pter
Size:
1,037 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/Swiss-Prot: HMN2_HUMAN, P0CJ69 (See protein sequence)
Recommended Name: Humanin-like protein 2  
Size: 28 amino acids; 3081 Da

Explore the universe of human proteins at neXtProt for MTRNR2L2: NX_P0CJ69

REFSEQ proteins: NP_001177399.1  
ENSEMBL proteins: 
 ENSP00000473917  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR028139 Humanin

Graphical View of Domain Structure for InterPro Entry P0CJ69

ProtoNet protein and cluster: P0CJ69

UniProtKB/Swiss-Prot: HMN2_HUMAN, P0CJ69
Similarity: Belongs to the humanin family


Find genes that share domains with MTRNR2L2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HMN2_HUMAN, P0CJ69
Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)
Induction: Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS
treatment. Up-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours
following beta-carotene treatment

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HMN2_HUMAN, P0CJ69: Cytoplasm (By similarity). Secreted (By similarity)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005737cytoplasm IEA--

Find genes that share ontologies with MTRNR2L2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MTRNR2L2 gene: 
NM_001190470.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000604882
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MTRNR2L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

UniProtKB/Swiss-Prot: HMN2_HUMAN, P0CJ69
Tissue specificity: Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for MTRNR2L2 (if available)
TreeFam Gene Tree for MTRNR2L2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MTRNR2L2 gene
5 SIMAP similar genes for MTRNR2L2 using alignment to 1 protein entry:     HMN2_HUMAN:
MTRNR2L1    MTRNR2L8    MT-RNR2    MTRNR2L5    MTRNR2L6

Find genes that share paralogs with MTRNR2L2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 3 variations for MTRNR2L2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv483112CNV Loss15286789
nsv10709CNV Loss18304495
esv23281CNV Gain+Loss19812545

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for MTRNR2L2:    
About MalaCards
alzheimer's disease


Find genes that share disorders with MTRNR2L2           About GenesLikeMe

Genetic Association Database (GAD): MTRNR2L2

Export disorders for MTRNR2L2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MTRNR2L2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MTRNR2L2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PubMed id 19477263)1, 2, 3 Bodzioch M....Dembinska-Kiec A. (Genomics 2009)
  2. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
  3. Humanin: a harbinger of mitochondrial-derived peptides? (PubMed id 23402768)1 Lee C....Cohen P. (Trends Endocrinol. Metab. 2013)
  4. Immunolocalization of humanin in human sperm and testis. (PubMed id 20542501)1 Moretti E....Collodel G. (Fertil. Steril. 2010)
  5. Humanin: a novel central regulator of peripheral insulin action. (PubMed id 19623253)1 Muzumdar R.H....Cohen P. (PLoS ONE 2009)
  6. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
  7. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PubMed id 12732850)1 Guo B....Reed J.C. (Nature 2003)
  8. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PubMed id 12009529)1 Tajima H.... Nishimoto I. (Neurosci. Lett. 2002)
  9. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PubMed id 11371646)1 Hashimoto Y.... Nashimoto I. (Proc. Natl. Acad. Sci. U.S.A. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100462981 HGNC: 37156 Ensembl:ENSG00000271043 euGenes: HUgn100462981 ECgene: MTRNR2L2
H-InvDB: MTRNR2L2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MTRNR2L2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MTRNR2L2 gene:
Search GeneIP for patents involving MTRNR2L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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