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Aliases for MTRNR2L12 Gene

Aliases for MTRNR2L12 Gene

  • MT-RNR2-Like 12 2 3 5
  • MT-RNR2-Like 12 (Pseudogene) 2 3
  • Humanin-Like 12 2 3
  • HN12 LncRNA 2 3
  • HN12 3 4
  • MT-RNR2-Like Protein 12 4
  • MTRNR2-Like 12 3

External Ids for MTRNR2L12 Gene

Previous GeneCards Identifiers for MTRNR2L12 Gene

  • GC03U901529
  • GC03M096338
  • GC03M096339
  • GC03M096343

Summaries for MTRNR2L12 Gene

GeneCards Summary for MTRNR2L12 Gene

MTRNR2L12 (MT-RNR2-Like 12) is a Protein Coding gene. An important paralog of this gene is MIR4485.

UniProtKB/Swiss-Prot for MTRNR2L12 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L12 Gene

Genomics for MTRNR2L12 Gene

Regulatory Elements for MTRNR2L12 Gene

Enhancers for MTRNR2L12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F096618 0.7 ENCODE 0.8 -0.1 -146 0.1 MTRNR2L12 RPL18AP8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MTRNR2L12 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTRNR2L12 Gene

96,617,186 bp from pter
96,618,236 bp from pter
1,051 bases
Minus strand

Genomic View for MTRNR2L12 Gene

Genes around MTRNR2L12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L12 Gene

Proteins for MTRNR2L12 Gene

  • Protein details for MTRNR2L12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 12
    Protein Accession:

    Protein attributes for MTRNR2L12 Gene

    27 amino acids
    Molecular mass:
    2961 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L12 Gene

Post-translational modifications for MTRNR2L12 Gene

No Post-translational modifications

Other Protein References for MTRNR2L12 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MTRNR2L12 Gene

Domains & Families for MTRNR2L12 Gene

Protein Domains for MTRNR2L12 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L12: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MTRNR2L12 Gene

Function for MTRNR2L12 Gene

Molecular function for MTRNR2L12 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MTRNR2L12 Gene

Localization for MTRNR2L12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L12 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L12: view

No data available for Subcellular locations from COMPARTMENTS for MTRNR2L12 Gene

Pathways & Interactions for MTRNR2L12 Gene

SuperPathways for MTRNR2L12 Gene

No Data Available

Interacting Proteins for MTRNR2L12 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L12 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L12 Gene

Transcripts for MTRNR2L12 Gene

mRNA/cDNA for MTRNR2L12 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L12 Gene

No ASD Table

Relevant External Links for MTRNR2L12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTRNR2L12 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L12 Gene

This gene is overexpressed in Brain - Amygdala (x8.2), Brain - Anterior cingulate cortex (BA24) (x7.2), Brain - Frontal Cortex (BA9) (x6.4), Brain - Substantia nigra (x4.7), Brain - Caudate (basal ganglia) (x4.6), and Brain - Hippocampus (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L12 Gene:

genes like me logo Genes that share expression patterns with MTRNR2L12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MTRNR2L12 Gene

Orthologs for MTRNR2L12 Gene

Evolution for MTRNR2L12 Gene

Gene Tree for MTRNR2L12 (if available)
Gene Tree for MTRNR2L12 (if available)

No data available for Orthologs for MTRNR2L12 Gene

Paralogs for MTRNR2L12 Gene

Paralogs for MTRNR2L12 Gene

genes like me logo Genes that share paralogs with MTRNR2L12: view

Variants for MTRNR2L12 Gene

Variation tolerance for MTRNR2L12 Gene

Gene Damage Index Score: 0.42; 9.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTRNR2L12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L12 Gene

Disorders for MTRNR2L12 Gene

No disorders were found for MTRNR2L12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for MTRNR2L12 Gene

Publications for MTRNR2L12 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4 64
  2. Apoptotic neuron-secreted HN12 inhibits cell apoptosis in Hirschsprung's disease. (PMID: 27853370) Du C. … Tang W. (Int J Nanomedicine 2016) 2 3 64
  3. MTRNR2L12: A Candidate Blood Marker of Early Alzheimer's Disease-Like Dementia in Adults with Down Syndrome. (PMID: 25720405) Bik-Multanowski M. … Midro A. (J. Alzheimers Dis. 2015) 3 64
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  5. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PMID: 12009529) Tajima H. … Nishimoto I. (Neurosci. Lett. 2002) 3 64

Products for MTRNR2L12 Gene

Sources for MTRNR2L12 Gene

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