MTRNR2L10 Gene
protein-coding GIFtS: 26
GCID: GC0XM055266
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MT-RNR2-like 10
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Aliases
for MTRNR2L10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MT-RNR2-Like 101 2 | | HN102 3 | | MT-RNR2-Like Protein 102 3 | | Humanin 102 | | Humanin-Like Protein 102 | | MTRNR2-Like 102 |
Export aliases for MTRNR2L10 gene to outside databasesPrevious GC identifers: GC0XU901540 GC0XM055217 GC0XM055243 GC0XM055247 GC0XM055253 GC0XM055261 |
Summaries
for MTRNR2L10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HMN10_HUMAN, P0CJ77Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)
|
Genomic Views
for MTRNR2L10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MTRNR2L10
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTRNR2L10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTRNR2L10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.21MTRNR2L10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM055266: view genomic region
(about GC identifiers)
Start:
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55,207,824 bp from pter |
End:
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55,208,944 bp from pter |
Size:
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1,121 bases |
Orientation:
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minus strand |
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Proteins
for MTRNR2L10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMN10_HUMAN, P0CJ77 (See
protein sequence)Recommended Name: Humanin-like protein 10 Size: 24 amino acids; 2806 Da
Subcellular location: Cytoplasm (By similarity). Secreted (By similarity)Explore the universe of human proteins at neXtProt for MTRNR2L10: NX_P0CJ77
MTRNR2L10 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001177637.1
ENSEMBL proteins: ENSP00000442159
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005737 | cytoplasm |
IEA | -- |
MTRNR2L10 for ontologies About GeneDecksing
MTRNR2L10 Antibody Products:
Assay Products for MTRNR2L10: |
Protein
Domains /
Families
for MTRNR2L10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P0CJ77 UniProtKB/Swiss-Prot: HMN10_HUMAN, P0CJ77Similarity: Belongs to the humanin family |
Function
for MTRNR2L10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HMN10_HUMAN, P0CJ77Function: Plays a role as a neuroprotective and antiapoptotic factor (By similarity)Induction: Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STStreatment. Down-regulated 6 hours following beta-carotene treatment, while it is up-regulated 24 hours followingbeta-carotene treatment
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Pathways & Interactions
for MTRNR2L10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTRNR2L10
|
Drugs & Compounds
for MTRNR2L10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTRNR2L10
Search CenterWatch for drugs/clinical trials and news about MTRNR2L10 / HMN10 
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Transcripts
for MTRNR2L10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTRNR2L10 gene: NM_001190708.1 Unigene Cluster for MTRNR2L10: MT-RNR2-like 10 Hs.722730 [show with all ESTs]Unigene Representative Sequence: NM_0011907081 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000545075(uc022bxr.1)
GeneLoc Exon Structure
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Expression
for MTRNR2L10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTRNR2L10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATTCTCA
About this image
SOURCE GeneReport for Unigene cluster: Hs.722730
UniProtKB/Swiss-Prot: HMN10_HUMAN, P0CJ77Tissue specificity: Expressed in mature brain, thyroid gland and testis
SABiosciences Custom PCR Arrays for MTRNR2L10
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MTRNR2L10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTRNR2L10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTRNR2L10 |
Orthologs
for MTRNR2L10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for MTRNR2L10 (if available)
TreeFam Gene Tree for MTRNR2L10 (if available) |
Paralogs
for MTRNR2L10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MTRNR2L10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MTRNR2L10 (55207824 - 55208944 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MTRNR2L10: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MTRNR2L10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTRNR2L10 for disorders About GeneDecksing
3  diseases for MTRNR2L10: About MalaCardsalzheimer's disease thyroiditis neuronitis
Export disorders for MTRNR2L10 gene to outside databases
|
Publications
for MTRNR2L10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTRNR2L10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MTRNR2L10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evidence for potential functionality of nuclearly-enc oded humanin isoforms. (PubMed id 19477263)1, 2, 3 Bodzioch M....Dembinska-Kiec A. (2009)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. (PubMed id 12009529)1 Tajima H.... Nishimoto I. (2002)
- A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. (PubMed id 11371646)1 Hashimoto Y.... Nashimoto I. (2001)
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External Searches for MTRNR2L10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MTRNR2L10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTRNR2L10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTRNR2L10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTRNR2L10 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MTRNR2L10 gene:
Search GeneIP for patents involving MTRNR2L10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTRNR2L10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTRNR2L10 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTRNR2L10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTRNR2L10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTRNR2L10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTRNR2L10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTRNR2L10 |
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 | | | MTRNR2L10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MTRNR2L10 |
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