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Aliases for MTRNR2L1 Gene

Aliases for MTRNR2L1 Gene

  • MT-RNR2-Like 1 2 3 5
  • Humanin-Like 1 2 3
  • HN1 3 4
  • Humanin-Like Protein 1 3
  • MT-RNR2-Like Protein 1 4
  • MTRNR2-Like 1 3

External Ids for MTRNR2L1 Gene

Previous GeneCards Identifiers for MTRNR2L1 Gene

  • GC17U901444
  • GC17P022091
  • GC17P022102
  • GC17P022116
  • GC17P022131
  • GC17P022142
  • GC17P022158
  • GC17P022269
  • GC17P022528
  • GC17P022735
  • GC17P022790

Summaries for MTRNR2L1 Gene

GeneCards Summary for MTRNR2L1 Gene

MTRNR2L1 (MT-RNR2-Like 1) is a Protein Coding gene. An important paralog of this gene is MTRNR2L6.

UniProtKB/Swiss-Prot for MTRNR2L1 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L1 Gene

Genomics for MTRNR2L1 Gene

Regulatory Elements for MTRNR2L1 Gene

Enhancers for MTRNR2L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MTRNR2L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTRNR2L1 Gene

Chromosome:
17
Start:
22,523,111 bp from pter
End:
22,524,665 bp from pter
Size:
1,555 bases
Orientation:
Plus strand

Genomic View for MTRNR2L1 Gene

Genes around MTRNR2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L1 Gene

Proteins for MTRNR2L1 Gene

  • Protein details for MTRNR2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ68-HMN1_HUMAN
    Recommended name:
    Humanin-like 1
    Protein Accession:
    P0CJ68

    Protein attributes for MTRNR2L1 Gene

    Size:
    24 amino acids
    Molecular mass:
    2691 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L1 Gene

Post-translational modifications for MTRNR2L1 Gene

No Post-translational modifications

Other Protein References for MTRNR2L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L1 Gene

Domains & Families for MTRNR2L1 Gene

Protein Domains for MTRNR2L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ68

UniProtKB/Swiss-Prot:

HMN1_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L1: view

No data available for Gene Families for MTRNR2L1 Gene

Function for MTRNR2L1 Gene

Molecular function for MTRNR2L1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L1 Gene

Localization for MTRNR2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L1 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTRNR2L1 Gene COMPARTMENTS Subcellular localization image for MTRNR2L1 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L1: view

Pathways & Interactions for MTRNR2L1 Gene

SuperPathways for MTRNR2L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTRNR2L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L1 Gene

Drugs & Compounds for MTRNR2L1 Gene

No Compound Related Data Available

Transcripts for MTRNR2L1 Gene

mRNA/cDNA for MTRNR2L1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L1 Gene

MT-RNR2-like 1:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L1 Gene

No ASD Table

Relevant External Links for MTRNR2L1 Gene

GeneLoc Exon Structure for
MTRNR2L1
ECgene alternative splicing isoforms for
MTRNR2L1

Expression for MTRNR2L1 Gene

mRNA expression in normal human tissues for MTRNR2L1 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L1 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.6), Brain - Putamen (basal ganglia) (x6.4), and Brain - Amygdala (x5.1).

Protein differential expression in normal tissues from HIPED for MTRNR2L1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTRNR2L1 Gene



Protein tissue co-expression partners for MTRNR2L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L1 Gene:

MTRNR2L1

SOURCE GeneReport for Unigene cluster for MTRNR2L1 Gene:

Hs.740185

mRNA Expression by UniProt/SwissProt for MTRNR2L1 Gene:

P0CJ68-HMN1_HUMAN
Tissue specificity: Highly expressed in the kidney, heart muscle and testis.
genes like me logo Genes that share expression patterns with MTRNR2L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MTRNR2L1 Gene

Orthologs for MTRNR2L1 Gene

Evolution for MTRNR2L1 Gene

ENSEMBL:
Gene Tree for MTRNR2L1 (if available)
TreeFam:
Gene Tree for MTRNR2L1 (if available)

No data available for Orthologs for MTRNR2L1 Gene

Paralogs for MTRNR2L1 Gene

Paralogs for MTRNR2L1 Gene

(7) SIMAP similar genes for MTRNR2L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L1: view

Variants for MTRNR2L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L1 Gene

Variant ID Type Subtype PubMed ID
dgv3128n100 CNV gain 25217958
dgv3131n100 CNV gain 25217958
dgv3132n100 CNV gain 25217958
dgv364n27 CNV gain 19166990
dgv517n67 CNV loss 20364138
dgv539e199 CNV deletion 23128226
esv2660756 CNV deletion 23128226
esv26964 CNV gain+loss 19812545
esv2751621 CNV gain 17911159
esv2751622 CNV gain 17911159
esv2758681 CNV gain+loss 17122850
esv3572520 CNV gain 25503493
esv3640266 CNV loss 21293372
esv3640267 CNV gain 21293372
esv3892985 CNV gain 25118596
esv3892986 CNV loss 25118596
nsv1057665 CNV gain 25217958
nsv1059146 CNV gain 25217958
nsv457715 CNV loss 19166990
nsv457716 CNV loss 19166990
nsv470584 CNV gain 18288195
nsv516664 CNV gain+loss 19592680
nsv574610 CNV gain 21841781
nsv574612 CNV gain+loss 21841781
nsv574613 CNV loss 21841781
nsv574614 CNV loss 21841781
nsv9526 CNV loss 18304495
nsv960079 CNV duplication 23825009

Variation tolerance for MTRNR2L1 Gene

Gene Damage Index Score: 0.10; 2.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTRNR2L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTRNR2L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MTRNR2L1 Gene

Disorders for MTRNR2L1 Gene

Relevant External Links for MTRNR2L1

Human Genome Epidemiology (HuGE) Navigator
MTRNR2L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTRNR2L1

No disorders were found for MTRNR2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L1 Gene

Publications for MTRNR2L1 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 2 3 4 65
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 65
  3. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. (PMID: 26990160) Sreekumar P.G. … Hinton D.R. (Invest. Ophthalmol. Vis. Sci. 2016) 3 65
  4. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C. … Breton S. (Mitochondrial DNA 2015) 3 65
  5. Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-I^. (PMID: 26216267) Njomen E. … Heyl D.L. (Protein Pept. Lett. 2015) 3 65

Products for MTRNR2L1 Gene

Sources for MTRNR2L1 Gene

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