Aliases for MTRF1L Gene
External Ids for MTRF1L Gene
Previous GeneCards Identifiers for MTRF1L Gene
The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
GeneCards Summary for MTRF1L Gene
MTRF1L (Mitochondrial Translational Release Factor 1-Like) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include translation release factor activity and translation release factor activity, codon specific. An important paralog of this gene is MTRF1.
UniProtKB/Swiss-Prot for MTRF1L Gene
Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.