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MTRF1L Gene

protein-coding   GIFtS: 53
GCID: GC06M153308

Mitochondrial Translational Release Factor 1-Like

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Translational Release Factor 1-Like1 2 3     Mitochondrial Release Factor 1 Like2
mtRF1a2 3     Peptide Chain Release Factor 1-Like, Mitochondrial2
HMRF1L2     MTRF1A3
MRF1L2     

External Ids:    HGNC: 210511   Entrez Gene: 545162   Ensembl: ENSG000001120317   OMIM: 6135425   UniProtKB: Q9UGC73   

Export aliases for MTRF1L gene to outside databases

Previous GC identifers: GC06M153264 GC06M153340 GC06M153401 GC06M153351 GC06M150871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTRF1L Gene:
Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins
involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L
is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases
mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 (PubMed 18429816)).(supplied
by OMIM, Nov 2010)

GeneCards Summary for MTRF1L Gene:
MTRF1L (mitochondrial translational release factor 1-like) is a protein-coding gene. Diseases associated with MTRF1L include optic atrophy, and ophthalmoplegia. GO annotations related to this gene include translation release factor activity, codon specific. An important paralog of this gene is MTRF1.

UniProtKB/Swiss-Prot: RF1ML_HUMAN, Q9UGC7
Function: Mitochondrial peptide chain release factor that directs the termination of translation in response to
the peptide chain termination codons UAA and UAG

Gene Wiki entry for MTRF1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTRF1L gene promoter:
         GR   Sox5   FOXO3   Nkx2-5   HNF-3beta   HNF-1A   FOXO3b   FOXC1   FOXO3a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTRF1L promoter sequence
   Search Chromatin IP Primers for MTRF1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTRF1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25-q26   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q25-q26

MTRF1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTRF1L gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M153308:  view genomic region     (about GC identifiers)

Start:
153,308,400 bp from pter      End:
153,323,925 bp from pter
Size:
15,526 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RF1ML_HUMAN, Q9UGC7 (See protein sequence)
Recommended Name: Peptide chain release factor 1-like, mitochondrial precursor  
Size: 380 amino acids; 43600 Da
Secondary accessions: B3KTA0 Q3KR06 Q5TF44 Q5TF50 Q96CC5 Q96EX4 Q96K40
Alternative splicing: 4 isoforms:  Q9UGC7-1   Q9UGC7-2   Q9UGC7-3   Q9UGC7-4   

Explore the universe of human proteins at neXtProt for MTRF1L: NX_Q9UGC7

Explore proteomics data for MTRF1L at MOPED

Post-translational modifications: 

  • Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTRF1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107656.1  NP_061914.3  

    ENSEMBL proteins: 
     ENSP00000414383   ENSP00000356202   ENSP00000356200   ENSP00000356199   ENSP00000415113  

    MTRF1L Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MTRF1L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014720 dsRNA-bd_dom
     IPR005139 PCRF
     IPR000352 Pep_chain_release_fac_I_II

    Graphical View of Domain Structure for InterPro Entry Q9UGC7

    ProtoNet protein and cluster: Q9UGC7

    1 Blocks protein domain: IPB000352 Class I peptide chain release factor domain

    UniProtKB/Swiss-Prot: RF1ML_HUMAN, Q9UGC7
    Similarity: Belongs to the prokaryotic/mitochondrial release factor family


    MTRF1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RF1ML_HUMAN, Q9UGC7
    Function: Mitochondrial peptide chain release factor that directs the termination of translation in response to
    the peptide chain termination codons UAA and UAG

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003747translation release factor activity ----
    GO:0016149translation release factor activity, codon specific IEA--
         
    MTRF1L for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mtrf1l):
     homeostasis/metabolism  mortality/aging 

    MTRF1L for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTRF1L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTRF1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTRF1L

    miRNA
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    miRTarBase miRNAs that target MTRF1L:
    hsa-mir-17-5p (MIRT050842), hsa-mir-26a-5p (MIRT050099), hsa-mir-125b-5p (MIRT046047), hsa-mir-196a-5p (MIRT048201)

    Block miRNA regulation of human, mouse, rat MTRF1L using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MTRF1L:
    hsa-miR-519e hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmidMTRF1L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MTRF1L

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    GenScript: all cDNA clones in your preferred vector (see all 2): MTRF1L (NM_019041)
    Sino Biological Human cDNA Clone for MTRF1L
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTRF1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTRF1L

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTRF1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RF1ML_HUMAN, Q9UGC7: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA--

    MTRF1L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTRF1L
    Interactions:

        Search GeneGlobe Interaction Network for MTRF1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTRF1L (Q9UGC73 ENSP000003562024) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MT-CO2P004033, ENSP000003548764I2D: score=1 STRING: ENSP00000354876
    HEMK1Q9Y5R43, ENSP000002328544I2D: score=5 STRING: ENSP00000232854
    N6AMT1Q9Y5N53, ENSP000003035844I2D: score=1 STRING: ENSP00000303584
    MT-CO1P003953, ENSP000003544994I2D: score=1 STRING: ENSP00000354499
    MPDU1O753523I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006415translational termination ----

    MTRF1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTRF1L (RF1ML)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTRF1L gene (2 alternative transcripts): 
    NM_001114184.1  NM_019041.5  

    Unigene Cluster for MTRF1L:

    Mitochondrial translational release factor 1-like
    Hs.225836  [show with all ESTs]
    Unigene Representative Sequence: NM_019041
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461949 ENST00000414771 ENST00000367233(uc003qpi.4 uc011efa.2)
    ENST00000464135(uc003qpj.4) ENST00000367231(uc003qpl.4) ENST00000367230(uc003qpk.4)
    ENST00000485512 ENST00000485283 ENST00000463251 ENST00000448966 ENST00000482526

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat MTRF1L using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MTRF1L:
    hsa-miR-519e hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmidMTRF1L 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MTRF1L
    Predesigned siRNA for gene silencing in human, mouse, rat MTRF1L
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    GenScript: all cDNA clones in your preferred vector (see all 2): MTRF1L (NM_019041)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTRF1L
      QuantiTect SYBR Green Assays in human, mouse, rat MTRF1L
      QuantiFast Probe-based Assays in human, mouse, rat MTRF1L

    Additional mRNA sequence: 

    AK001037.1 AK027684.1 AK095240.1 AK225321.1 AK225970.1 AK290662.1 AK297671.1 AL049992.1 
    BC011873.2 BC014428.1 BC105973.1 

    22 DOTS entries:

    DT.97841761  DT.92428057  DT.100790932  DT.95174222  DT.95174220  DT.121396156  DT.100790930  DT.205990 
    DT.75153380  DT.95174221  DT.95118787  DT.121269434  DT.91952549  DT.99968141  DT.100790928  DT.75109609 
    DT.75110081  DT.121396047  DT.121396114  DT.91649607  DT.95133838  DT.95174223 

    Selected AceView cDNA sequences (see all 206):

    AI803987 BX423351 BM855571 AW295335 BQ947765 AI873974 AA282019 AI915742 
    BG491412 AI372887 F35597 AI868646 CK903839 AA577353 AI225109 CB995736 
    AI333479 CR616466 AI434611 AK001037 AI474350 BE155591 BM838509 BM994815 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTRF1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAGTCAG
    MTRF1L Expression
    About this image

    MTRF1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTRF1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.225836

    UniProtKB/Swiss-Prot: RF1ML_HUMAN, Q9UGC7
    Tissue specificity: Expressed in skeletal muscle (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTRF1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MTRF1L gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtrf1l1 , 5 mitochondrial translational release factor 1-like1, 5 81.49(n)1
    82.75(a)1
      10 (1.91 cM)5
    1088531  NM_175374.31  NP_780583.11 
     58118875 
    chicken
    (Gallus gallus)
    Aves MTRF1L1 mitochondrial translational release factor 1-like 72.74(n)
    70.87(a)
      421643  XM_419682.3  XP_419682.2 
    lizard
    (Anolis carolinensis)
    Reptilia MTRF1L6
    mitochondrial translational release factor 1-like
    64(a)
    1 ↔ 1
    1(215804136-215812401)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.133852 Transcribed sequence with weak similarity to protein more 81.8(n)    BX730605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003337331 peptide chain release factor 1-like, mitochondrial-like 62.66(n)
    59.76(a)
      100333733  XM_002664226.3  XP_002664272.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57051 CG5705 51.21(n)
    47.32(a)
      34720  NM_135773.3  NP_609617.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W03F8.31 W03F8.3 47.35(n)
    37.38(a)
      177294  NM_068336.6  NP_500737.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRF1(YGL143C)4
    MRF11
    Mitochondrial translation release factor, involved more4
    MRF11
    49.78(n)1
    43.05(a)1
      7(235958-234717)4
    8527341, 4  NP_011372.31  NP_011372.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APG31 APG3 52.23(n)
    42.68(a)
      825466  NM_116156.4  NP_191850.2 
    rice
    (Oryza sativa)
    Liliopsida Os11g06571001 Os11g0657100 51.98(n)
    42.77(a)
      4351050  NM_001074926.1  NP_001068394.1 


    ENSEMBL Gene Tree for MTRF1L (if available)
    TreeFam Gene Tree for MTRF1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTRF1L gene
    MTRF12  
    1 SIMAP similar gene for MTRF1L using alignment to 4 protein entries:     RF1ML_HUMAN (see all proteins):
    MTRF1

    MTRF1L for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MTRF1L
    PGOHUM00000242895 PGOHUM00000249799 PGOHUM00000250041


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTRF1L (see all 373)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122153631,2
    C,A--153307949(+) GCATGA/GGGGCG 2 -- ds50012Minor allele frequency- G:0.25NA 4
    rs122017711,2
    C,F,A--153308040(+) AGATCG/ACGCCA 2 -- ds50013Minor allele frequency- A:0.50NA 6
    rs1927335261,2
    --153308041(+) GATCAC/TGCCAT 2 -- ds50010--------
    rs615852461,2
    C--153308142(+) TCTAT-/GTACCA 2 -- ds50010--------
    rs69211371,2
    C,F,A,H--153308198(+) attttG/Tggcca 2 -- ds500129Minor allele frequency- T:0.23NS EA NA WA CSA 2765
    rs1842767651,2
    --153308291(+) TCTCCC/TGCGGG 2 -- ds50010--------
    rs121899651,2
    C,F,A,H--153308312(+) cctctG/Tgatga 2 -- ds500119Minor allele frequency- T:0.14NS EA NA CSA WA 2342
    rs669345241,2
    C--153308368(+) AGGCC-/CTTTACAA 2 -- cds10--------
    rs772259861,2
    C--153308370(+) GGCCTT/ACAACA 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs589079051,2
    C,F--153308380(+) ATAAAG/AAACAA 2 -- ds50012Minor allele frequency- A:0.06WA NA 238

    HapMap Linkage Disequilibrium report for MTRF1L (153308400 - 153323925 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MTRF1L: --
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613542    OMIM disorders: --

    9 diseases for MTRF1L:    About MalaCards
    optic atrophy    ophthalmoplegia    encephalomyopathy    cleft lip
    pneumonia    tuberculosis    malaria    prostate cancer
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for MTRF1L:
    Leigh disease     Ophthalmoplegia

    MTRF1L for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTRF1L
    Human Genome Epidemiology (HuGE) Navigator: MTRF1L (2 documents)

    Export disorders for MTRF1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTRF1L gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MTRF1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC. (PubMed id 18541145)1, 2 Ishizawa T.... Takeuchi N. (Biochem. Biophys. Res. Commun. 2008)
    3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    4. mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. (PubMed id 17803939)1, 2 Soleimanpour-Lichaei H.R....Chrzanowska-Lightowlers Z. (Mol. Cell 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mutations in C12orf65 in patients with encephalomyopathy and a mitochondrial translation defect. (PubMed id 20598281)1 Antonicka H.... Shoubridge E.A. (Am. J. Hum. Genet. 2010)
    9. HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG. (PubMed id 18429816)1 Nozaki Y....Takeuchi N. (amp 2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54516 HGNC: 21051 AceView: MTRF1L Ensembl:ENSG00000112031 euGenes: HUgn54516
    ECgene: MTRF1L H-InvDB: MTRF1L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTRF1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTRF1L gene:
    Search GeneIP for patents involving MTRF1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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