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Aliases for MTRF1 Gene

Aliases for MTRF1 Gene

  • Mitochondrial Translational Release Factor 1 2 3
  • Mitochontrial Peptide Chain Release Factor 1 2 3
  • MtRF-1 3 4
  • MRF-1 3 4
  • Peptide Chain Release Factor 1, Mitochondrial 3
  • MTTRF1 3
  • MRF1 3
  • RF1 3

External Ids for MTRF1 Gene

Previous GeneCards Identifiers for MTRF1 Gene

  • GC13M039777
  • GC13M035777
  • GC13M040727
  • GC13M039588
  • GC13M040689
  • GC13M041790
  • GC13M022590

Summaries for MTRF1 Gene

Entrez Gene Summary for MTRF1 Gene

  • The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTRF1 Gene

MTRF1 (Mitochondrial Translational Release Factor 1) is a Protein Coding gene. GO annotations related to this gene include translation release factor activity and translation release factor activity, codon specific. An important paralog of this gene is MTRF1L.

UniProtKB/Swiss-Prot for MTRF1 Gene

  • Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA

Gene Wiki entry for MTRF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRF1 Gene

Genomics for MTRF1 Gene

Genomic Location for MTRF1 Gene

Start:
41,216,369 bp from pter
End:
41,263,577 bp from pter
Size:
47,209 bases
Orientation:
Minus strand

Genomic View for MTRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRF1 Gene

No data available for Regulatory Elements for MTRF1 Gene

Proteins for MTRF1 Gene

  • Protein details for MTRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75570-RF1M_HUMAN
    Recommended name:
    Peptide chain release factor 1, mitochondrial
    Protein Accession:
    O75570
    Secondary Accessions:
    • B4DG01
    • Q5T6Y5
    • Q8IUQ6

    Protein attributes for MTRF1 Gene

    Size:
    445 amino acids
    Molecular mass:
    52306 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MTRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTRF1 Gene

Proteomics data for MTRF1 Gene at MOPED

Post-translational modifications for MTRF1 Gene

  • Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTRF1 Gene

No data available for DME Specific Peptides for MTRF1 Gene

Domains for MTRF1 Gene

Protein Domains for MTRF1 Gene

Graphical View of Domain Structure for InterPro Entry

O75570

UniProtKB/Swiss-Prot:

RF1M_HUMAN :
  • O75570
Family:
  • Belongs to the prokaryotic/mitochondrial release factor family.
genes like me logo Genes that share domains with MTRF1: view

No data available for Gene Families for MTRF1 Gene

Function for MTRF1 Gene

Molecular function for MTRF1 Gene

UniProtKB/Swiss-Prot Function: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA

Gene Ontology (GO) - Molecular Function for MTRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003747 translation release factor activity TAS 9838146
GO:0016149 translation release factor activity, codon specific IEA --
genes like me logo Genes that share ontologies with MTRF1: view

Phenotypes for MTRF1 Gene

MGI mutant phenotypes for MTRF1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MTRF1: view

Animal Model Products

CRISPR Products

miRNA for MTRF1 Gene

miRTarBase miRNAs that target MTRF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTRF1 Gene

Localization for MTRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRF1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTRF1 Gene COMPARTMENTS Subcellular localization image for MTRF1 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MTRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MTRF1: view

Pathways for MTRF1 Gene

SuperPathways for MTRF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006415 translational termination IEA --
GO:0006449 regulation of translational termination TAS 9838146
genes like me logo Genes that share ontologies with MTRF1: view

No data available for Pathways by source for MTRF1 Gene

Transcripts for MTRF1 Gene

Unigene Clusters for MTRF1 Gene

Mitochondrial translational release factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTRF1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MTRF1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - -
SP11: - - -

ExUns: 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for MTRF1 Gene

GeneLoc Exon Structure for
MTRF1
ECgene alternative splicing isoforms for
MTRF1

Expression for MTRF1 Gene

mRNA expression in normal human tissues for MTRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTRF1 Gene

SOURCE GeneReport for Unigene cluster for MTRF1 Gene Hs.382176

genes like me logo Genes that share expressions with MTRF1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTRF1 Gene

Orthologs for MTRF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MTRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTRF1 35
  • 99.93 (n)
  • 100 (a)
MTRF1 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTRF1 35
  • 88.54 (n)
  • 88.09 (a)
MTRF1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTRF1 35
  • 89.67 (n)
  • 87.33 (a)
MTRF1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtrf1 35
  • 84.49 (n)
  • 82.02 (a)
Mtrf1 16
Mtrf1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTRF1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTRF1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtrf1 35
  • 83.41 (n)
  • 81.76 (a)
chicken
(Gallus gallus)
Aves MTRF1 35
  • 68.82 (n)
  • 66.59 (a)
MTRF1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTRF1 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10531 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mtrf1 35
  • 66.14 (n)
  • 67.63 (a)
zebrafish
(Danio rerio)
Actinopterygii mtrf1 35
  • 63.39 (n)
  • 67.52 (a)
mtrf1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5705 36
  • 34 (a)
OneToMany
CG5705 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea W03F8.3 36
  • 28 (a)
OneToMany
W03F8.3 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRF1 36
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G47020 35
  • 52.66 (n)
  • 45.6 (a)
rice
(Oryza sativa)
Liliopsida Os05g0277300 35
  • 50.63 (n)
  • 46.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for MTRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTRF1 Gene

ENSEMBL:
Gene Tree for MTRF1 (if available)
TreeFam:
Gene Tree for MTRF1 (if available)

Paralogs for MTRF1 Gene

Paralogs for MTRF1 Gene

Selected SIMAP similar genes for MTRF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTRF1: view

Variants for MTRF1 Gene

Sequence variations from dbSNP and Humsavar for MTRF1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs944790 -- 41,246,241(-) AAACC(A/G)CCAAT intron-variant
rs1050878 -- 41,240,381(-) AAGCA(C/T)TTGAA synonymous-codon, reference, intron-variant
rs1332939 -- 41,264,699(-) TTTAA(C/G)GTTGT upstream-variant-2KB
rs1332940 -- 41,260,953(-) TAGAG(A/C/G)TGATT intron-variant
rs1541115 -- 41,258,498(-) agtag(C/G)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTRF1 Gene

Variant ID Type Subtype PubMed ID
nsv832587 CNV Gain 17160897
nsv1014 CNV Insertion 18451855
esv2747301 CNV Deletion 23290073
nsv1015 CNV Insertion 18451855

Relevant External Links for MTRF1 Gene

HapMap Linkage Disequilibrium report
MTRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRF1 Gene

Disorders for MTRF1 Gene

(2) University of Copenhagen DISEASES for MTRF1 Gene

(1) Novoseek inferred disease relationships for MTRF1 Gene

Disease -log(P) Hits PubMed IDs
sterility male 83.6 3

Relevant External Links for MTRF1

Genetic Association Database (GAD)
MTRF1
Human Genome Epidemiology (HuGE) Navigator
MTRF1
genes like me logo Genes that share disorders with MTRF1: view

No data available for UniProtKB/Swiss-Prot for MTRF1 Gene

Publications for MTRF1 Gene

  1. Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor. (PMID: 9838146) Zhang Y. … Spremulli L.L. (Biochim. Biophys. Acta 1998) 2 3 4
  2. Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1-->q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32-->q34.1 with radiation hybrid mapping. (PMID: 10773675) Hansen L.L. … Justesen J. (Cytogenet. Cell Genet. 2000) 2 3
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4

Products for MTRF1 Gene

Sources for MTRF1 Gene

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