Aliases for MTREX Gene
External Ids for MTREX Gene
Previous HGNC Symbols for MTREX Gene
GeneCards Summary for MTREX Gene
UniProtKB/Swiss-Prot for MTREX Gene
Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3-processing of the 7S pre-RNA to the mature 5.8S rRNA.