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MTPN Gene

protein-coding   GIFtS: 54

GC07M135262
myotrophin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FLJ31098 2
FLJ99857 2
GCDP 1, 2
MYOTROPHIN 1
V-1 1, 2
myotrophin 2
Descriptions
Protein V-1 3
granule cell differentiation protein 2
External Ids
HGNC: 156671
Entrez Gene: 1363192
UniProtKB: P585463
Ensembl: ENSG000001058877
Search outside databases for aliases for MTPN gene

Previous GC identifers: GC07U990334 GC07M133953 GC07M135013 GC07M135027 GC07M135068

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MTPN:
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine
zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is
involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers.
This protein also has a potential function in cerebellar morphogenesis, and it may be involved in
the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the
3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation
initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated
with myeloproliferative disease. [provided by RefSeq]

UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546
Function: Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar
neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy

Gene Wiki entry for MTPN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MTPN gene  

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33-q35

MTPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M135262:     (about GC identifiers)

Start:
135,262,049 bp from pter
End:
135,312,647 bp from pter
Size:
50,599 bases
Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 134,955,946-135,006,505     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079596.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546 (See protein sequence)
Recommended Name: Myotrophin  
Size: 118 amino acids; 12895 Da
Subcellular location: Cytoplasm (By similarity)
Miscellaneous: This protein is produced by a bicistronic gene which also produces the MPD6 protein
from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without
conventional genomic structure. It is encoded by a cryptic open reading frame located in the
3'-untranslated region of MTPN

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_665807.1  

    ENSEMBL proteins: 
    ENSP00000349140 ENSP00000376800 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Myotrophin)
    Human Recombinant Proteins from Abnova (MTPN)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0005622 intracellular IDA11256614
    GO:0005737 cytoplasm IEA--
    GO:0030424 axon IEA--
    About this table

    Antibodies for MTPN: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MTPN
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Myotrophin), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (MTPN)
    Novus Biologicals Antibodies for MTPN

    Assays for MTPN: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR002110 ANK


       GeneDecks  MTPN for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P58546

    ProtoNet protein and cluster: P58546

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546
    Similarity: Belongs to the myotrophin family
    Similarity: Contains 3 ANK repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MTPN)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MTPN)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145808

                  Applied Biosystems Silencer® siRNAs for MTPN

                  Sigma-Aldrich siRNA for MTPN  
                         Sigma-Aldrich shRNA for MTPN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for MTPN
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_145808
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_145808
                                     untagged cDNA clone in CMV expression vector: NM_145808 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_145808

    UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546
    Function: Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar
    neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding NAS12031792
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MTPN 


    4 Interacting proteins for MTPN (ENSP000003491403 P585461) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DSTYKQ6XUX31EBI-1051736, EBI-1049520
    CAPZBENSP000003642873STRING (score=.852)
    RELAENSP000003115083STRING (score=.766)
    NFKB1ENSP000002265743STRING (score=.765)
    About this table

    5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417 regulation of translation NAS12031792
    GO:0006584 catecholamine metabolic process IEA--
    GO:0016049 cell growth NAS12031792
    GO:0016202 regulation of striated muscle development NAS12031792
    GO:0021707 cerebellar granule cell differentiation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MTPN
    2 Novoseek chemical compound relationships for MTPN gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 32.96 4 9633917 (3), 7758156 (1)
    tyrosine 0.00 2 9633917 (2)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MTPN)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MTPN)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145808

                  Sigma-Aldrich siRNA for MTPN  
                         Sigma-Aldrich shRNA for MTPN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_145808  

    REFSEQ mRNAs for MTPN gene: 

    NM_145808.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_145808  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_145808
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_145808
                                     untagged cDNA clone in CMV expression vector: NM_145808 

    Additional cDNA sequence: 

    AF106075.1 AF130088.1 AK056225.1 AK309816.1 AL110137.1 AL834231.1 AY611627.1 BC028093.1 
    BC034722.1 

    13 DOTS entries:

    DT.448286  DT.100011161  DT.100798496  DT.95255802  DT.100798500  DT.100798503  DT.101971329  DT.95074637 
    DT.100798505  DT.102829456  DT.121041665  DT.40219617  DT.121041651 

    24/642 AceView cDNA sequences (see all 642 ):

    CR611568 AI880861 BU156531 BM705947 AW081292 BU735313 BX280742 BM476367 
    AA329670 AA055475 AI800394 BQ671412 BQ025002 BP374229 BQ438171 AA463690 
    AW474049 AA846874 AI651321 AV755413 BG679041 AA887481 T63872 AA564972 

    highest scoring ESTs for MTPN:

    R67204 AA279574 AA374586 AA521352 AA743780 AF106075 AI694841 AI818116 AL527816 AL550701 

    Unigene Clusters for MTPN:

    Myotrophin
    Hs.602015  [show with all ESTs], Hs.654894  [show with all ESTs]
    Unigene Representative Sequences: XM_001726675, NM_001128619


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MTPN

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -     -               

    About this scheme

    ECgene alternative splicing isoforms for MTPN

    2 Ensembl transcripts including schematic representations:
    ENST00000356707  ENST00000393085  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MTPN expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MTPN

    1 / 2 / 3

    5 probe-sets matching MTPN gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    76577_at2, 3 U95-E 2 1.00 0.50 0.80 0.76 R67204 1.00 1.00 1.00 1

    45306_at2, 3 U95-B 2 1.00 0.50 0.33 1.62 AA742560 0.60 0.83 0.73 1

    64202_at2, 3 U95-C 2 0.62 0.55 0.86 0.64 R67205 0.80 1.00 0.91 1

    224656_s_at2, 3 U133-B 2 1.00 0.50 -- -- AL533334 0.40 1.00 0.76 1

    224656_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
    GeneDecks  MTPN for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.602015 Hs.654894

    UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546
    Tissue specificity: Ubiquitous

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MTPN gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MTPN1   -- myotrophin 96.05(n)
    100(a)
    403487  NM_001002989.1  NP_001002989.1 
    chimpanzee
    (Pan troglodytes)
    MTPN1   -- myotrophin 100(n)
    100(a)
    463756  XM_001146879.1  XP_001146879.1 
    cow
    (Bos taurus)
    MTPN1   -- myotrophin 94.92(n)
    100(a)
    541099  NM_203362.2  NP_976238.2 
    rat
    (Rattus norvegicus)
    Mtpn1   -- myotrophin 96.61(n)
    99.15(a)
    79215  NM_024374.3  NP_077350.1 
    mouse
    (Mus musculus)
    Mtpn1, 5 65
    myotrophin1, 5 97.46(n)1
    99.15(a)1
    144891  NM_008098.31  NP_032124.11 
     AK0026205  AK0280275  (see all 35)
    About this table        Species with no ortholog for MTPN

    ENSEMBL Gene Tree for MTPN
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/278 NCBI SNPs in MTPN are shown (see all 278 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 110)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs78111341,2
    A,C,F,H135313922(+) TACAAG/ATCCAC 1 -- ng3111Minor allele frequency- A:0.46EU EA WA NA 920
    rs38235751,2
    C,F,H135312821(+) CTGGGA/CGGCAG 1 -- ng316Minor allele frequency- C:0.13MN EA EU WA 1670
    --
    rs102355041,2
    A,C135314112(+) agcacC/Tttggg 1 -- ng310--------
    --
    rs175534131,2
    F135312872(-) TCTCA-/ACTCTT 1 -- ng312Minor allele frequency- A:0.18MN EA 1252
    rs69741831,2
    H135312857(+) AGACAG/ACGAAT 1 -- ng314Minor allele frequency- A:0.00EU EA WA 418
    --
    rs117629071,2
    C135314182(+) tgagaA/Caccat 1 -- ng310--------
    rs41425151,2
    A,C,F,H135306640(+) TAAGCG/ATGTTG 1 -- int17Minor allele frequency- A:0.42NA EU EA WA 560
    rs102759471,2
    A,C,F,H135294166(+) TTTCAG/CTAAAG 1 -- int14Minor allele frequency- C:0.39EU EA WA 418
    rs77814261,2
    A,C,F,H135312089(+) CGCCTG/AACTGT 1 -- int17Minor allele frequency- A:0.43NA EU EA WA 562
    --
    rs47321631,2
    A,C,F,H135304282(+) AACTAT/Cattgt 1 -- int14Minor allele frequency- C:0.39EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for MTPN (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606484

    4 Novoseek disease relationships for MTPN gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 73.28 17 14970239 (3), 18693253 (2), 9634699 (2), 10329199 (2) (see all 9)
    hypertrophy 59.00 14 15532712 (2), 14970239 (2), 8428777 (2), 9633917 (1) (see all 9)
    heart failure 39.65 12 14970239 (4), 12932609 (2), 15946807 (1), 15385543 (1) (see all 6)
    ventricular hypertrophy 27.51 3 10329199 (1), 11023986 (1)
    About this table

    Genetic Association Database: MTPN

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/44 PubMed articles for MTPN gene (see all 44 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 136319 HGNC: 15667 AceView: MTPN Ensembl:ENSG00000105887 euGenes: HUgn136319
    ECgene: MTPN H-InvDB: MTPN
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MTPN:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for MTPN-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for MTPN Antibodies for MTPN
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MTPN Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
    (Myotrophin)
     Antibodies (Myotrophin)
     Search OriGene for MTPN
     Search Tocris compounds for MTPN




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for MTPN

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