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Aliases & Descriptions for MTPN
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ31098 2 | | FLJ99857 2 | | GCDP 1, 2 | | MYOTROPHIN 1 | | V-1 1, 2 | | myotrophin 2 |
| | | Descriptions |
|---|
| Protein V-1 3 | | granule cell differentiation protein 2 |
|
| | Search outside databases for aliases for MTPN genePrevious GC identifers: GC07U990334 GC07M133953 GC07M135013 GC07M135027 GC07M135068 |
Summaries for MTPN(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MTPN: The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq] UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546Function: Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophyGene Wiki entry for MTPN |
Genomic Location for MTPN
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the MTPN gene 
Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33-q35MTPN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M135262:
(about GC identifiers)
Start:
|
135,262,049 bp from pter |
End:
|
135,312,647 bp from pter |
Size:
|
50,599 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 134,955,946-135,006,505 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079596.2
| Proteins for MTPN
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546 (See
protein sequence)Recommended Name: Myotrophin Size: 118 amino acids; 12895 Da
Subcellular location: Cytoplasm (By similarity)
Miscellaneous: This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPNPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_665807.1
ENSEMBL proteins: ENSP00000349140 ENSP00000376800
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for MTPN: Assays for MTPN: | Protein
Domains/ Families for MTPN(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P58546
ProtoNet protein and cluster: P58546 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546Similarity: Belongs to the myotrophin familySimilarity: Contains 3 ANK repeats | Gene Function for MTPN
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145808
Applied Biosystems Silencer® siRNAs for MTPN
Sigma-Aldrich siRNA for MTPN  Sigma-Aldrich shRNA for MTPN  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145808                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_145808                                  untagged cDNA clone in CMV expression vector: NM_145808 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_145808
UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546Function: Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for MTPN
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for MTPN 
4 Interacting proteins for MTPN (ENSP000003491403 P585461) via UniProtKB, MINT, and/or STRINGAbout this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
): About this table
|
Drugs & Compounds for MTPN(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for MTPN 2 Novoseek chemical compound relationships for MTPN gene
About this table
|
Transcripts for MTPN(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145808
Sigma-Aldrich siRNA for MTPN  Sigma-Aldrich shRNA for MTPN  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_145808 REFSEQ mRNAs for MTPN gene: NM_145808.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_145808               OriGene GFP tagged cDNA clone in CMV expression vector: NM_145808                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_145808                                  untagged cDNA clone in CMV expression vector: NM_145808  Additional cDNA sequence: AF106075.1 AF130088.1 AK056225.1 AK309816.1 AL110137.1 AL834231.1 AY611627.1 BC028093.1 BC034722.1 13 DOTS entries: DT.448286 DT.100011161 DT.100798496 DT.95255802 DT.100798500 DT.100798503 DT.101971329 DT.95074637 DT.100798505 DT.102829456 DT.121041665 DT.40219617 DT.121041651 24/642 AceView cDNA sequences (see all 642
):CR611568 AI880861 BU156531 BM705947 AW081292 BU735313 BX280742 BM476367 AA329670 AA055475 AI800394 BQ671412 BQ025002 BP374229 BQ438171 AA463690 AW474049 AA846874 AI651321 AV755413 BG679041 AA887481 T63872 AA564972
highest scoring ESTs for MTPN:R67204 AA279574 AA374586 AA521352 AA743780 AF106075 AI694841 AI818116 AL527816 AL550701 Unigene Clusters for MTPN: Myotrophin Hs.602015 [show with all ESTs], Hs.654894 [show with all ESTs]Unigene Representative Sequences: XM_001726675, NM_001128619
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MTPN
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | |
| SP1: | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for MTPN
2 Ensembl transcripts including schematic representations: ENST00000356707
ENST00000393085
|
Expression for MTPN
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MTPN expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MTPN
1 / 2 / 3 5 probe-sets matching MTPN gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.602015 Hs.654894 UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546Tissue specificity: Ubiquitous |
Orthologs for MTPN
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MTPN gene from 5/12 species (see all 12
)
About this table Species with no ortholog for MTPN
ENSEMBL Gene Tree for MTPN | Paralogs for MTPN(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for MTPN(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MTPN (up to first 250kb)
|
Disorders & Mutations for MTPN
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606484
4 Novoseek disease relationships for MTPN gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cardiac hypertrophy |
73.28 |
17 |
14970239 (3), 18693253 (2), 9634699 (2), 10329199 (2) (see all 9) |
| hypertrophy |
59.00 |
14 |
15532712 (2), 14970239 (2), 8428777 (2), 9633917 (1) (see all 9) |
| heart failure |
39.65 |
12 |
14970239 (4), 12932609 (2), 15946807 (1), 15385543 (1) (see all 6) |
| ventricular hypertrophy |
27.51 |
3 |
10329199 (1), 11023986 (1) |
About this table
Genetic Association Database: MTPN
|
Medical News for MTPN(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for MTPN (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/44 PubMed articles for MTPN gene (see all 44
):- cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy. (PubMed id 10329199)1, 3, 4 Anderson K.M.... Chabot-Fletcher M. (1999)
- Assignment of myotrophin to human chromosome band 7q33-->q35 by in situ hybridization. (PubMed id 11474205)1, 2, 3 Mitra S....Sen S. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Myotrophin in human cardiomyopathic heart. (PubMed id 8508536)1, 3 Sil P....Sen S. (1993)
- Myotrophin in human heart failure. (PubMed id 12932609)1, 6 O'Brien R.J....Ng L.L. (2003)
- Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro. (PubMed id 8576259)1, 3 Sivasubramanian N....Sen S. (1996)
- Myotrophin induces early response genes and enhances cardiac gene expression. (PubMed id 8428777)1, 3 Mukherjee D.P....Sen S. (1993)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
|
Search for MTPN
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MTPN
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MTPN
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTPN(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for MTPN(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for MTPN:

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Incremental update: 13 Oct 2009
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