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Aliases for MTPN Gene

Aliases for MTPN Gene

  • Myotrophin 2 3 5
  • Granule Cell Differentiation Protein 2 3
  • Protein V-1 3 4
  • GCDP 3
  • V-1 3

External Ids for MTPN Gene

Previous GeneCards Identifiers for MTPN Gene

  • GC07U990334
  • GC07M133953
  • GC07M135013
  • GC07M135027
  • GC07M135068
  • GC07M135262
  • GC07M135613

Summaries for MTPN Gene

Entrez Gene Summary for MTPN Gene

  • The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTPN Gene

MTPN (Myotrophin) is a Protein Coding gene. Diseases associated with MTPN include motor neuritis and hypophosphatemic rickets with hypercalciuria.

UniProtKB/Swiss-Prot for MTPN Gene

  • Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.

Gene Wiki entry for MTPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTPN Gene

Genomics for MTPN Gene

Regulatory Elements for MTPN Gene

Promoters for MTPN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTPN on UCSC Golden Path with GeneCards custom track

Genomic Location for MTPN Gene

Chromosome:
7
Start:
135,926,755 bp from pter
End:
135,977,456 bp from pter
Size:
50,702 bases
Orientation:
Minus strand

Genomic View for MTPN Gene

Genes around MTPN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTPN Gene

Proteins for MTPN Gene

  • Protein details for MTPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58546-MTPN_HUMAN
    Recommended name:
    Myotrophin
    Protein Accession:
    P58546

    Protein attributes for MTPN Gene

    Size:
    118 amino acids
    Molecular mass:
    12895 Da
    Quaternary structure:
    • Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.
    Miscellaneous:
    • This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3-untranslated region of MTPN.

    Three dimensional structures from OCA and Proteopedia for MTPN Gene

neXtProt entry for MTPN Gene

Proteomics data for MTPN Gene at MOPED

Post-translational modifications for MTPN Gene

  • Ubiquitination at Lys 4 and Lys 11
  • Modification sites at PhosphoSitePlus

Other Protein References for MTPN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTPN Gene

Domains & Families for MTPN Gene

Gene Families for MTPN Gene

Protein Domains for MTPN Gene

Suggested Antigen Peptide Sequences for MTPN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58546

UniProtKB/Swiss-Prot:

MTPN_HUMAN :
  • Belongs to the myotrophin family.
  • Contains 3 ANK repeats.
Family:
  • Belongs to the myotrophin family.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with MTPN: view

Function for MTPN Gene

Molecular function for MTPN Gene

UniProtKB/Swiss-Prot Function:
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
UniProtKB/Swiss-Prot Induction:
Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of myocardial ischemia. Up-regulated in heart left ventricle of patients with dilated cardiomyopathy.
genes like me logo Genes that share phenotypes with MTPN: view

Animal Model Products

miRNA for MTPN Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTPN Gene

Localization for MTPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTPN Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTPN Gene COMPARTMENTS Subcellular localization image for MTPN gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MTPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MTPN: view

Pathways & Interactions for MTPN Gene

SuperPathways for MTPN Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016049 cell growth IDA 10329199
GO:0016202 regulation of striated muscle tissue development NAS 12031792
GO:0021707 cerebellar granule cell differentiation IEA --
GO:0030182 neuron differentiation NAS 12031792
GO:0030307 positive regulation of cell growth IEA,ISS --
genes like me logo Genes that share ontologies with MTPN: view

No data available for Pathways by source and SIGNOR curated interactions for MTPN Gene

Drugs & Compounds for MTPN Gene

(2) Drugs for MTPN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTPN: view

Transcripts for MTPN Gene

mRNA/cDNA for MTPN Gene

Unigene Clusters for MTPN Gene

Myotrophin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTPN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: - -

Relevant External Links for MTPN Gene

GeneLoc Exon Structure for
MTPN
ECgene alternative splicing isoforms for
MTPN

Expression for MTPN Gene

mRNA expression in normal human tissues for MTPN Gene

Protein differential expression in normal tissues from HIPED for MTPN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTPN Gene



SOURCE GeneReport for Unigene cluster for MTPN Gene Hs.602015

mRNA Expression by UniProt/SwissProt for MTPN Gene

P58546-MTPN_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MTPN: view

Protein tissue co-expression partners for MTPN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTPN Gene

Orthologs for MTPN Gene

This gene was present in the common ancestor of animals.

Orthologs for MTPN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTPN 35
  • 100 (n)
  • 100 (a)
MTPN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTPN 36
  • 100 (a)
OneToOne
MTPN 35
  • 94.92 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia MTPN 35
  • 96.05 (n)
  • 100 (a)
MTPN 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtpn 36
  • 99 (a)
OneToOne
Mtpn 16
Mtpn 35
  • 97.46 (n)
  • 99.15 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MTPN 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtpn 35
  • 96.89 (n)
  • 99.15 (a)
chicken
(Gallus gallus)
Aves MTPN 36
  • 76 (a)
OneToOne
MTPN 35
  • 90.68 (n)
  • 97.46 (a)
lizard
(Anolis carolinensis)
Reptilia MTPN 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5094 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76285 35
mtpn 35
  • 74.29 (n)
  • 78.81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7923 35
zebrafish
(Danio rerio)
Actinopterygii mtpn 36
  • 80 (a)
OneToOne
mtpn 35
  • 72.88 (n)
  • 79.66 (a)
wufa10f07 35
fruit fly
(Drosophila melanogaster)
Insecta CG31715 36
  • 49 (a)
OneToMany
CG7423 36
  • 40 (a)
OneToMany
CG31715 35
  • 60.63 (n)
  • 50.86 (a)
worm
(Caenorhabditis elegans)
Secernentea C43H6.3 35
  • 51.99 (n)
  • 44.04 (a)
C43H6.3 36
  • 42 (a)
OneToOne
Species with no ortholog for MTPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTPN Gene

ENSEMBL:
Gene Tree for MTPN (if available)
TreeFam:
Gene Tree for MTPN (if available)

Paralogs for MTPN Gene

genes like me logo Genes that share paralogs with MTPN: view

No data available for Paralogs for MTPN Gene

Variants for MTPN Gene

Structural Variations from Database of Genomic Variants (DGV) for MTPN Gene

Variant ID Type Subtype PubMed ID
dgv7494n71 CNV Loss 21882294
dgv7496n71 CNV Loss 21882294
nsv824314 CNV Loss 20364138

Variation tolerance for MTPN Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTPN Gene

HapMap Linkage Disequilibrium report
MTPN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MTPN Gene

Disorders for MTPN Gene

MalaCards: The human disease database

(2) MalaCards diseases for MTPN Gene - From: DISEASES

Disorder Aliases PubMed IDs
motor neuritis
  • peripheral motor neuropathy
hypophosphatemic rickets with hypercalciuria
  • hereditary hypophosphatemic rickets with hypercalciuria
- elite association - COSMIC cancer census association via MalaCards
Search MTPN in MalaCards View complete list of genes associated with diseases

Relevant External Links for MTPN

Genetic Association Database (GAD)
MTPN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTPN
genes like me logo Genes that share disorders with MTPN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTPN Gene

Publications for MTPN Gene

  1. cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy. (PMID: 10329199) Anderson K.M. … Chabot-Fletcher M. (J. Mol. Cell. Cardiol. 1999) 3 4 23 67
  2. Assignment of myotrophin to human chromosome band 7q33-->q35 by in situ hybridization. (PMID: 11474205) Mitra S. … Sen S. (Cytogenet. Cell Genet. 2001) 2 3 23
  3. Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro. (PMID: 8576259) Sivasubramanian N. … Sen S. (J. Biol. Chem. 1996) 3 23
  4. Myotrophin induces early response genes and enhances cardiac gene expression. (PMID: 8428777) Mukherjee D.P. … Sen S. (Hypertension 1993) 3 23
  5. Myotrophin in human cardiomyopathic heart. (PMID: 8508536) Sil P. … Sen S. (Circ. Res. 1993) 3 23

Products for MTPN Gene

Sources for MTPN Gene

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