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MTPN Gene

protein-coding   GIFtS: 50
GCID: GC07M135613

Myotrophin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
myotrophin1 2
Granule Cell Differentiation Protein1 2
Protein V-12 3
GCDP2
V-12

External Ids:    HGNC: 156671   Entrez Gene: 1363192   Ensembl: ENSG000001058877   OMIM: 6064845   UniProtKB: P585463   

Export aliases for MTPN gene to outside databases

Previous GC identifers: GC07U990334 GC07M133953 GC07M135013 GC07M135027 GC07M135068 GC07M135262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTPN Gene:
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein
6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of
NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in
cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of
granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a
non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is
associated with myeloproliferative disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for MTPN Gene:
MTPN (myotrophin) is a protein-coding gene.

UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546
Function: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By
similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the
F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes,
but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy

Gene Wiki entry for MTPN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MTPN
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MTPN promoter sequence
   Search Chromatin IP Primers for MTPN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33-q35

MTPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTPN gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M135613:  view genomic region     (about GC identifiers)

Start:
135,611,503 bp from pter      End:
135,662,204 bp from pter
Size:
50,702 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 134,955,940-135,006,645     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546 (See protein sequence)
Recommended Name: Myotrophin  
Size: 118 amino acids; 12895 Da
Subunit: Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB
Miscellaneous: This protein is produced by a bicistronic gene which also produces the MPD6 protein from a
non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic
structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN
1 PDB 3D structure from and Proteopedia for MTPN:
3AAA (3D)    

Explore the universe of human proteins at neXtProt for MTPN: NX_P58546

Explore proteomics data for MTPN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys4, Lys11
  • Modification sites at PhosphoSitePlus

  • See MTPN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_665807.1  
    ENSEMBL proteins: 
     ENSP00000376800   ENSP00000388321  

    MTPN Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P58546

    ProtoNet protein and cluster: P58546

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546
    Similarity: Belongs to the myotrophin family
    Similarity: Contains 3 ANK repeats


    Find genes that share domains with MTPN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTPN_HUMAN, P58546
    Function: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By
    similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the
    F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes,
    but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy
    Induction: Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of
    myocardial ischemia. Up-regulated in heart left ventricle of patients with dilated cardiomyopathy

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MTPN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MTPN:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTPN
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    hsa-mir-122-5p (MIRT023322), hsa-mir-124-3p (MIRT001834), hsa-mir-20a-3p (MIRT038976), hsa-mir-130b-5p (MIRT038329), hsa-let-7b-5p (MIRT001850), hsa-mir-503-5p (MIRT041109), hsa-mir-21-5p (MIRT030848), hsa-mir-331-3p (MIRT043449), hsa-mir-375 (MIRT000054)

    Block miRNA regulation of human, mouse, rat MTPN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTPN (see all 118):
    hsa-miR-140-5p hsa-miR-323-3p hsa-miR-548j hsa-miR-200a hsa-miR-605 hsa-miR-4275 hsa-miR-3162-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidMTPN 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTPN_HUMAN, P58546: Cytoplasm (Probable). Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol ISS--
    GO:0008290F-actin capping protein complex IDA16895918
    GO:0030424axon IEA--

    Find genes that share ontologies with MTPN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTPN
    Interactions:

        GeneGlobe Interaction Network for MTPN

    Selected Interacting proteins for MTPN (P585463) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284823I2D: score=3 
    CAPZBP477563I2D: score=2 
    DSTYKQ6XUX33I2D: score=2 
    NFKB1P198383I2D: score=2 
    RELAQ042063I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation NAS12031792
    GO:0006584catecholamine metabolic process IEA--
    GO:0010557positive regulation of macromolecule biosynthetic process ISS--
    GO:0010613positive regulation of cardiac muscle hypertrophy IMP10329199
    GO:0016049cell growth IDA10329199

    Find genes that share ontologies with MTPN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTPN

    2 Novoseek inferred chemical compound relationships for MTPN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 30.8 4 9633917 (3), 7758156 (1)
    tyrosine 0 2 9633917 (2)



    Find genes that share compounds with MTPN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTPN gene: 
    NM_145808.3  

    Unigene Cluster for MTPN:

    Myotrophin
    Hs.602015  [show with all ESTs]
    Unigene Representative Sequence: NM_145808
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393085(uc003vte.4 uc010lmv.3) ENST00000435723
    miRNA
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    Block miRNA regulation of human, mouse, rat MTPN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTPN (see all 118):
    hsa-miR-140-5p hsa-miR-323-3p hsa-miR-548j hsa-miR-200a hsa-miR-605 hsa-miR-4275 hsa-miR-3162-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidMTPN 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for MTPN
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      QuantiTect SYBR Green Assays in human, mouse, rat MTPN
      QuantiFast Probe-based Assays in human, mouse, rat MTPN

    Additional mRNA sequence: 

    AF106075.1 AF130088.2 AK055660.1 AK056225.1 AK309816.1 AL110137.1 AL834231.1 AY611627.1 
    BC028093.1 BC034722.1 

    14 DOTS entries:

    DT.448286  DT.100011161  DT.100798496  DT.95255802  DT.100798500  DT.100798503  DT.100798505  DT.101971329 
    DT.102829456  DT.40219617  DT.95074637  DT.121014771  DT.121041651  DT.121041665 

    Selected AceView cDNA sequences (see all 642):

    BQ434108 BX281433 CA390182 CD676327 AI564507 AA463690 AA770400 AA385817 
    CR611568 CB111401 AA825763 BU735373 BI334815 AL110137 AI873985 BU183734 
    AL134864 AA714200 BI028556 BM470015 AA826286 BM664350 AW304152 AA337068 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MTPN    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -     -               


    ECgene alternative splicing isoforms for MTPN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTPN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATCCGAA
    MTPN Expression
    About this image


    MTPN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MTPN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTPN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.602015

    UniProtKB/Swiss-Prot: MTPN_HUMAN, P58546
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTPN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtpn1 , 5 myotrophin1, 5 97.46(n)1
    99.15(a)1
      6 (15.27 cM)5
    144891  NM_008098.41  NP_032124.11 
     355089065 
    chicken
    (Gallus gallus)
    Aves MTPN1 myotrophin 90.68(n)
    97.46(a)
      395702  NM_204886.1  NP_990217.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTPN6
    myotrophin
    96(a)
    1 ↔ 1
    GL343602.1(167047-197300)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.50942 Xenopus laevis transcribed sequence with weak similarity more 83.23(n)    BJ072987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10f072 Danio rerio cDNA clone MGC64078 IMAGE6794528, complete more 74.66(n)    BC054609.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317151 CG31715 60.63(n)
    50.86(a)
      318909  NM_164917.2  NP_723568.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C43H6.31 C43H6.3 51.99(n)
    44.04(a)
      180545  NM_076036.5  NP_508437.1 


    ENSEMBL Gene Tree for MTPN (if available)
    TreeFam Gene Tree for MTPN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTPN gene
    Selected SIMAP similar genes for MTPN using alignment to 2 protein entries:     MTPN_HUMAN (see all proteins) (see all similar genes):
    DKFZp761E1322    MTMR8    ANKDD1A    BARD1    ESPN    LOC91526
    ANKRD28    IBTK    TNKS    ANK3    ANKDD1B    ANKS6
    GPR75-ASB3    HACE1    ANK2    ANKRD31    ANKRD35    ANKRD42

    Find genes that share paralogs with MTPN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MTPN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv824314CNV Loss20364138
    dgv7496n71CNV Loss21882294
    dgv7494n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606484    OMIM disorders: --


    Find genes that share disorders with MTPN           About GenesLikeMe

    4 Novoseek inferred disease relationships for MTPN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 73.3 17 14970239 (3), 18693253 (2), 9634699 (2), 10329199 (2) (see all 9)
    hypertrophy 59.3 15 15532712 (2), 14970239 (2), 8428777 (2), 9633917 (1) (see all 10)
    heart failure 40.6 12 14970239 (4), 12932609 (2), 15946807 (1), 15385543 (1) (see all 6)
    ventricular hypertrophy 25.1 3 10329199 (1), 11023986 (1)

    Genetic Association Database (GAD): MTPN

    Export disorders for MTPN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTPN gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with MTPN)
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    1. cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy. (PubMed id 10329199)1, 2, 9 Anderson K.M.... Chabot-Fletcher M. (J. Mol. Cell. Cardiol. 1999)
    2. Assignment of myotrophin to human chromosome band 7q33--&gt;q35 by in situ hybridization. (PubMed id 11474205)1, 3, 9 Mitra S....Sen S. (Cytogenet. Cell Genet. 2001)
    3. Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end. (PubMed id 16895918)1, 2 Bhattacharya N.... Cooper J.A. (J. Biol. Chem. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Myotrophin in human cardiomyopathic heart. (PubMed id 8508536)1, 9 Sil P....Sen S. (Circ. Res. 1993)
    7. Myotrophin in human heart failure. (PubMed id 12932609)4, 9 O'Brien R.J....Ng L.L. (J. Am. Coll. Cardiol. 2003)
    8. Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro. (PubMed id 8576259)1, 9 Sivasubramanian N....Sen S. (J. Biol. Chem. 1996)
    9. Myotrophin induces early response genes and enhances cardiac gene expression. (PubMed id 8428777)1, 9 Mukherjee D.P....Sen S. (Hypertension 1993)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 136319 HGNC: 15667 AceView: MTPN Ensembl:ENSG00000105887 euGenes: HUgn136319
    ECgene: MTPN H-InvDB: MTPN

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTPN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTPN gene:
    Search GeneIP for patents involving MTPN

    GeneCards and IP:
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