Aliases for MTPAP Gene
External Ids for MTPAP Gene
Previous HGNC Symbols for MTPAP Gene
Previous GeneCards Identifiers for MTPAP Gene
The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]
GeneCards Summary for MTPAP Gene
MTPAP (Mitochondrial Poly(A) Polymerase) is a Protein Coding gene. Diseases associated with MTPAP include ataxia, spastic, 4. GO annotations related to this gene include RNA binding and identical protein binding. An important paralog of this gene is TUT1.
UniProtKB/Swiss-Prot for MTPAP Gene
Polymerase that creates the 3 poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.