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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTPAP Gene

protein-coding   GIFtS: 48
GCID: GC10M030598

mitochondrial poly(A) polymerase

(Previous name: PAP associated domain containing 1 )
(Previous symbol: PAPD1)
 Explore 11 diseases affiliated with
MTPAP via our new
 Human Malady Compendium 
Biological research products
for MTPAP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Poly(A) Polymerase1 2     SPAX42 5
PAPD11 2 3 5     FLJ104861
MtPAP1     PAP Associated Domain Containing 11
Polynucleotide Adenylyltransferase2 3     Poly(A) RNA Polymerase, Mitochondrial2
Terminal Uridylyltransferase 12 3     EC 2.7.7.193
PAP-Associated Domain-Containing Protein 12 3     PAP3
TUTase 12 3     

External Ids:    HGNC: 255321   Entrez Gene: 551492   Ensembl: ENSG000001079517   OMIM: 6136695   UniProtKB: Q9NVV43   

Export aliases for MTPAP gene to outside databases

Previous GC identifers: GC10M030642 GC10M030317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTPAP:
The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3'
poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.(provided
by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
Function: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but
has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May
be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be
responsible for the creation of some UAA stop codons which are not encoded in mtDNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTPAP gene promoter:
         E2F-4   E2F-3a   E2F-5   CUTL1   E2F-2   C/EBPalpha   CHOP-10   AREB6   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTPAP promoter sequence
   Search SABiosciences Chromatin IP Primers for MTPAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTPAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.23   Ensembl cytogenetic band:  10p11.23   HGNC cytogenetic band: 10p12.1

MTPAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTPAP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M030598:  view genomic region     (about GC identifiers)

Start:
30,598,730 bp from pter      End:
30,663,377 bp from pter
Size:
64,648 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4 (See protein sequence)
Recommended Name: Poly(A) RNA polymerase, mitochondrial precursor  
Size: 582 amino acids; 66172 Da
Cofactor: Magnesium or manganese
Subunit: Homodimer
Subcellular location: Cytoplasm. Mitochondrion
1 PDB 3D structure from and Proteopedia for MTPAP:
3PQ1 (3D)    
Secondary accessions: D3DRX0 Q659E3 Q6P7E5 Q9HA74
Alternative splicing: 2 isoforms:  Q9NVV4-1   Q9NVV4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTPAP: NX_Q9NVV4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NVV4

  • MTPAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060579.3  
    ENSEMBL proteins: 
     ENSP00000263063   ENSP00000404392   ENSP00000394118   ENSP00000350820  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MTPAP

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005794Golgi apparatus IDA--


    MTPAP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MTPAP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002058 PAP_assoc

    Graphical View of Domain Structure for InterPro Entry Q9NVV4

    ProtoNet protein and cluster: Q9NVV4

    1 Blocks protein family: IPB002058 PAP/25A-associated domain

    UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
    Similarity: Belongs to the DNA polymerase type-B-like family
    Similarity: Contains 1 PAP-associated domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
    Function: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but
    has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May
    be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be
    responsible for the creation of some UAA stop codons which are not encoded in mtDNA
    Catalytic activity: ATP + RNA(n) = diphosphate + RNA(n+1)
    Biophysicochemical properties: Kinetic parameters: KM=0.1 mM for ATP; KM=0.7 mM for UTP;

    Enzyme Number (IUBMB): EC 2.7.7.191

    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate MTPAP (see all 24):
    hsa-miR-548j hsa-miR-676 hsa-miR-548i hsa-miR-218 hsa-miR-3133 hsa-miR-548a-3p hsa-miR-7-1* hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidMTPAP 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA--
    GO:0002134UTP binding IDA--
    GO:0003723RNA binding IEA--
    GO:0004652polynucleotide adenylyltransferase activity IDA--
    GO:0005515protein binding IPI--


    MTPAP for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTPAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/238 Interacting proteins for MTPAP (Q9NVV41, 2, 3 ENSP000002630634) via UniProtKB, MINT, STRING, and/or I2D (see all 238)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 3, ENSP000003299674EBI-2556166,EBI-1383470 I2D: score=1 STRING: ENSP00000329967
    CALCOCO2Q131371, 3, ENSP000002589474EBI-2556166,EBI-739580 I2D: score=1 STRING: ENSP00000258947
    AZI2Q9H6S13, ENSP000004193714I2D: score=1 STRING: ENSP00000419371
    ICT1Q141972, ENSP000003015854MINT-8079030 STRING: ENSP00000301585
    NEK9Q8TD193I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006378mRNA polyadenylation IDA--
    GO:0008219cell death IEA--
    GO:0071044histone mRNA catabolic process IMP18172165


    MTPAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTPAP
    Search CenterWatch for drugs/clinical trials and news about MTPAP / PAPD1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTPAP gene: 
    NM_018109.3  

    Unigene Cluster for MTPAP:

    Mitochondrial poly(A) polymerase
    Hs.173946  [show with all ESTs]
    Unigene Representative Sequence: NM_018109
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263063 ENST00000488290(uc001ivf.1) ENST00000417581 ENST00000421701(uc001ivc.2)
    ENST00000471055(uc001ivd.2) ENST00000358107(uc001iva.4 uc001ivb.4)


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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate MTPAP (see all 24):
    hsa-miR-548j hsa-miR-676 hsa-miR-548i hsa-miR-218 hsa-miR-3133 hsa-miR-548a-3p hsa-miR-7-1* hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidMTPAP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTPAP (see all 4)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTPAP
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTPAP
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    Additional cDNA sequence: 

    AB194709.1 AK001348.1 AK022188.1 AK125211.1 AY364242.1 BC061703.1 

    10 DOTS entries:

    DT.410378  DT.92426294  DT.101980928  DT.429324  DT.121303648  DT.121303684  DT.92426296  DT.121303747 
    DT.91642227  DT.92426292 

    24/119 AceView cDNA sequences (see all 119):

    BE145764 CA945008 AL122121 AW473989 AW008991 BX115191 Z45791 T71331 
    AW243841 AI167205 AA400998 CA487835 AA618549 BM905354 BX645123 AA884787 
    AI635291 BM801639 AI744411 BQ000745 BU619051 BQ272568 BM819197 AK001348 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MTPAP (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -     -     -                             -                                                               
    SP2:              -     -     -     -                             -                                                               
    SP3:              -     -     -     -                 -     -     -                                                               
    SP4:                          -     -                             -                                                               
    SP5:                                                              -                                                               


    ECgene alternative splicing isoforms for MTPAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTPAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MTPAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTPAP

    SOURCE GeneReport for Unigene cluster: Hs.173946

    UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
    Tissue specificity: Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and
    skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTPAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MTPAP gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MTPAP1 mitochondrial poly(A) polymerase 65.35(n)
    58(a)
      420478  XM_418580.3  XP_418580.3 
    lizard
    (Anolis carolinensis)
    Reptilia MTPAP6
    --
    60(a)
    1 ↔ 1
    6(13462017-13474043)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.26322 Xenopus laevis transcribed sequence with weak similarity more 70.78(n)    BU900678.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173442 Transcribed sequence with weak similarity to protein more 72.95(n)    BM184671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG114181 CG11418 43.1(n)
    34.45(a)
      31081  NM_130548.3  NP_569904.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G397406
    AT3G457606
    (see all 4)
    Nucleotidyltransferase family protein
    (see all 4)
    15(a)
    14(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    2(16575752-16579120)
    3(16801996-16804967)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 6)
    expressed protein
    (see all 6)
    23(a)
    20(a)
    (see all 6)
    possible ortholog
    many ↔ many
    (see all 6)
    10(6121021-6126841)
    1(36358666-36364450)


    ENSEMBL Gene Tree for MTPAP (if available)
    TreeFam Gene Tree for MTPAP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTPAP gene
    ENSG000002555082  TUT12  ZCCHC62  ZCCHC112  PAPD42  

    MTPAP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/833 NCBI SNPs in MTPAP are shown (see all 833    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1513208041,2
    --30598242(+) CAACAA/GCAAAT 1 -- ds50010--------
    rs1813651631,2
    --30598333(+) ACTTCC/TGCGTA 1 -- ds50010--------
    rs744399201,2
    --30598342(+) TATCAC/TATTAA 1 -- ds50012Minor allele frequency- T:0.21CSA WA 119
    rs1406532111,2
    --30598535(+) TTCCCC/TACCAC 1 -- ds50010--------
    rs1863710581,2
    --30598541(+) ACCACA/GGCACC 1 -- ds50010--------
    rs1889220081,2
    --30598652(+) TACAGC/TGTAAG 1 -- ds50010--------
    rs7907601,2
    C,F,H,--30598666(-) CTCTAG/CTCAGG 1 -- ds500117Minor allele frequency- C:0.25NS EA NA WA CSA 794
    rs1504008291,2
    --30598702(+) AAGACA/GCCAAT 1 -- ds50010--------
    rs1465357531,2
    --30598713(+) AGGAAA/GTGACA 1 -- ds50010--------
    rs1816601631,2
    --30598813(+) CTATAA/CCGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MTPAP (30598730 - 30663377 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MTPAP
         4 CNVs: 85167 75164 65631 4674
    Human Gene Mutation Database (HGMD): MTPAP

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MTPAP for disorders           About GeneDecksing

    OMIM gene information: 613669   
    OMIM disorders: 613672  
    UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
  • Defects in MTPAP are the cause of spastic ataxia autosomal recessive type 4 (SPAX4) [MIM:613672]. A slowly
  • progressive neurodegenerative disease characterized by cerebellar ataxia, spastic paraparesis, dysarthria, and optic
    atrophy. Note=Affected individuals exhibit a drastic decrease in poly(A) tail length of representative mitochondrial
    mRNA transcripts, including COX1 and RNA14 (PubMed:20970105)

    11 diseases for MTPAP:    About MalaCards
    ataxia, spastic, 4    spastic paraparesis    spasticity    optic atrophy
    cerebellar ataxia    spastic ataxia    ataxia    neurodegenerative disease
    alzheimer's disease    obesity    malaria

    Human Genome Epidemiology (HuGE) Navigator: MTPAP (6 documents)

    Export disorders for MTPAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTPAP gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with MTPAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase. (PubMed id 15769737)1, 2, 3 Nagaike T.... Ueda T. (2005)
    2. Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase. (PubMed id 15547249)1, 2, 3 Tomecki R....Stepien P.P. (2004)
    3. Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. (PubMed id 21292163)1, 2 Bai Y.... Tong L. (2011)
    4. Defective mitochondrial mRNA maturation is associated with spastic ataxia. (PubMed id 20970105)1, 2 Crosby A.H....Lightowlers R.N. (2010)
    5. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    9. Gene regulation: reviving the message. (PubMed id 12239557)1, 3 Keller W. and Martin G. (2002)
    10. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55149 HGNC: 25532 AceView: PAPD1 Ensembl:ENSG00000107951 euGenes: HUgn55149
    ECgene: MTPAP H-InvDB: MTPAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTPAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTPAP gene:
    Search GeneIP for patents involving MTPAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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