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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTPAP Gene

protein-coding   GIFtS: 51
GCID: GC10M030598

Mitochondrial Poly(A) Polymerase

(Previous name: PAP associated domain containing 1)
(Previous symbol: PAPD1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Poly(A) Polymerase1 2     TUTase11
PAPD11 2 3 5     PAP Associated Domain Containing 11
Polynucleotide Adenylyltransferase2 3     Poly(A) RNA Polymerase, Mitochondrial2
Terminal Uridylyltransferase 12 3     EC 2.7.7.193
PAP-Associated Domain-Containing Protein 12 3     PAP3
TUTase 12 3     mtPAP3
SPAX42 5     

External Ids:    HGNC: 255321   Entrez Gene: 551492   Ensembl: ENSG000001079517   OMIM: 6136695   UniProtKB: Q9NVV43   

Export aliases for MTPAP gene to outside databases

Previous GC identifers: GC10M030642 GC10M030317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTPAP Gene:
The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the
3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA
degradation.(provided by RefSeq, Jan 2011)

GeneCards Summary for MTPAP Gene: 
MTPAP (mitochondrial poly(A) polymerase) is a protein-coding gene. Diseases associated with MTPAP include ataxia, spastic, 4, and optic atrophy. GO annotations related to this gene include RNA binding and identical protein binding. An important paralog of this gene is ENSG00000255508.

UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
Function: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides,
but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA
degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is
initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTPAP gene promoter:
         E2F-4   E2F-3a   E2F-5   CUTL1   E2F-2   C/EBPalpha   CHOP-10   AREB6   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTPAP promoter sequence
   Search SABiosciences Chromatin IP Primers for MTPAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTPAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.23   Ensembl cytogenetic band:  10p11.23   HGNC cytogenetic band: 10p12.1

MTPAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTPAP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M030598:  view genomic region     (about GC identifiers)

Start:
30,598,730 bp from pter      End:
30,663,377 bp from pter
Size:
64,648 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4 (See protein sequence)
Recommended Name: Poly(A) RNA polymerase, mitochondrial precursor  
Size: 582 amino acids; 66172 Da
Cofactor: Magnesium or manganese
Subunit: Homodimer
Subcellular location: Cytoplasm. Mitochondrion
1 PDB 3D structure from and Proteopedia for MTPAP:
3PQ1 (3D)    
Secondary accessions: D3DRX0 Q659E3 Q6P7E5 Q9HA74
Alternative splicing: 2 isoforms:  Q9NVV4-1   Q9NVV4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTPAP: NX_Q9NVV4

Explore proteomics data for MTPAP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVV4

  • MTPAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTPAP Protein Expression
    REFSEQ proteins: NP_060579.3  
    ENSEMBL proteins: 
     ENSP00000263063   ENSP00000404392   ENSP00000394118   ENSP00000350820  

    Human Recombinant Protein Products for MTPAP: 
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    Cloud-Clone Corp. Proteins for MTPAP 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005794Golgi apparatus IDA--

    MTPAP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002058 PAP_assoc

    Graphical View of Domain Structure for InterPro Entry Q9NVV4

    ProtoNet protein and cluster: Q9NVV4

    1 Blocks protein domain: IPB002058 PAP/25A-associated domain

    UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
    Similarity: Belongs to the DNA polymerase type-B-like family
    Similarity: Contains 1 PAP-associated domain


    MTPAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAPD1_HUMAN, Q9NVV4
    Function: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides,
    but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA
    degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is
    initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA
    Catalytic activity: ATP + RNA(n) = diphosphate + RNA(n+1)
    Biophysicochemical properties: Kinetic parameters: KM=0.1 mM for ATP; KM=0.7 mM for UTP;

         Enzyme Number (IUBMB): EC 2.7.7.191

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA--
    GO:0002134UTP binding IDA--
    GO:0003723RNA binding IEA--
    GO:0004652polynucleotide adenylyltransferase activity IDA--
    GO:0005515protein binding IPI--
         
    MTPAP for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTPAP 
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    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate MTPAP (see all 24):
    hsa-miR-548j hsa-miR-676 hsa-miR-548i hsa-miR-218 hsa-miR-3133 hsa-miR-548a-3p hsa-miR-7-1* hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidMTPAP 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTPAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/252 Interacting proteins for MTPAP (Q9NVV41, 2, 3 ENSP000002630634) via UniProtKB, MINT, STRING, and/or I2D (see all 252)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 3, ENSP000003299674EBI-2556166,EBI-356402 I2D: score=1 STRING: ENSP00000329967
    CALCOCO2Q131371, 3, ENSP000002589474EBI-2556166,EBI-739580 I2D: score=1 STRING: ENSP00000258947
    AZI2Q9H6S13, ENSP000004193714I2D: score=1 STRING: ENSP00000419371
    ICT1Q141972, ENSP000003015854MINT-8079030 STRING: ENSP00000301585
    NEK9Q8TD193I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006378mRNA polyadenylation IDA--
    GO:0008219cell death IEA--
    GO:0071044histone mRNA catabolic process IMP18172165

    MTPAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTPAP (PAPD1)

    Search CenterWatch for drugs/clinical trials and news about MTPAP / PAPD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTPAP gene: 
    NM_018109.3  

    Unigene Cluster for MTPAP:

    Mitochondrial poly(A) polymerase
    Hs.173946  [show with all ESTs]
    Unigene Representative Sequence: NM_018109
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263063 ENST00000488290(uc001ivf.1) ENST00000417581 ENST00000421701(uc001ivc.2)
    ENST00000471055(uc001ivd.2) ENST00000358107(uc001iva.4 uc001ivb.4)


    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate MTPAP (see all 24):
    hsa-miR-548j hsa-miR-676 hsa-miR-548i hsa-miR-218 hsa-miR-3133 hsa-miR-548a-3p hsa-miR-7-1* hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidMTPAP 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB194709.1 AK001348.1 AK022188.1 AK125211.1 AY364242.1 BC061703.1 

    10 DOTS entries:

    DT.410378  DT.92426294  DT.101980928  DT.429324  DT.121303648  DT.121303684  DT.92426296  DT.121303747 
    DT.91642227  DT.92426292 

    24/119 AceView cDNA sequences (see all 119):

    AW473989 Z45791 AA618549 AI167205 CA945008 BM905354 BQ272568 AI744411 
    AA884787 T71331 BX115191 BM801639 AW008991 BX645123 AA400998 AL122121 
    AI635291 AW243841 CA487835 BM819197 AI681826 BQ000745 AK001348 BU619051 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MTPAP (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -     -     -                             -                                                               
    SP2:              -     -     -     -                             -                                                               
    SP3:              -     -     -     -                 -     -     -                                                               
    SP4:                          -     -                             -                                                               
    SP5:                                                              -                                                               


    ECgene alternative splicing isoforms for MTPAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTPAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MTPAP Expression
    About this image


    See MTPAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTPAP

    SOURCE GeneReport for Unigene cluster: Hs.173946

    UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
    Tissue specificity: Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain,
    and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTPAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MTPAP gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtpap1 , 5 mitochondrial poly(A) polymerase1, 5 79.69(n)1
    76.76(a)1
      18 (2.77 cM)5
    674401  NM_026157.21  NP_080433.11 
     43755925 
    chicken
    (Gallus gallus)
    Aves MTPAP1 mitochondrial poly(A) polymerase 65.35(n)
    58(a)
      420478  XM_418580.3  XP_418580.3 
    lizard
    (Anolis carolinensis)
    Reptilia MTPAP6
    mitochondrial poly(A) polymerase
    57(a)
    1 ↔ 1
    6(13462011-13475249)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.26322 Xenopus laevis transcribed sequence with weak similarity more 70.78(n)    BU900678.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173442 Transcribed sequence with weak similarity to protein more 72.95(n)    BM184671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG114181 CG11418 43.1(n)
    34.45(a)
      31081  NM_130548.3  NP_569904.1 


    ENSEMBL Gene Tree for MTPAP (if available)
    TreeFam Gene Tree for MTPAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTPAP gene
    ENSG000002555082  TUT12  ZCCHC62  ZCCHC112  PAPD42  

    MTPAP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1007 SNPs in MTPAP are shown (see all 1007)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0649074
    Spastic ataxia autosomal recessive 4 (SPAX4)4--see VAR_0649072 N D mis40--------
    rs1513208041,2
    C--30503632(+) CAACAA/GCAAAT 1 -- ds50010--------
    rs1813651631,2
    --30503723(+) ACTTCC/TGCGTA 1 -- ds50010--------
    rs744399201,2
    C,F--30503732(+) TATCAC/TATTAA 1 -- ds50012Minor allele frequency- T:0.21CSA WA 119
    rs1406532111,2
    --30503925(+) TTCCCC/TACCAC 1 -- ds50010--------
    rs1863710581,2
    --30503931(+) ACCACA/GGCACC 1 -- ds50010--------
    rs1889220081,2
    --30504042(+) TACAGC/TGTAAG 1 -- ds50010--------
    rs7907601,2
    C,F,H--30504056(-) CTCTAG/CTCAGG 1 -- ds500117Minor allele frequency- C:0.25NS EA NA WA CSA 794
    rs1504008291,2
    C--30504092(+) AAGACA/GCCAAT 1 -- ds50010--------
    rs1465357531,2
    --30504103(+) AGGAAA/GTGACA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MTPAP (30598730 - 30663377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MTPAP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509349CNV Insertion20534489
    nsv831821CNV Loss17160897
    esv21514CNV Loss19812545
    nsv894993CNV Gain21882294


    Human Gene Mutation Database (HGMD): MTPAP
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613669   
    OMIM disorders: 613672  
    UniProtKB/Swiss-Prot: PAPD1_HUMAN, Q9NVV4
  • Spastic ataxia autosomal recessive 4 (SPAX4) [MIM:613672]: A slowly progressive neurodegenerative disease
    characterized by cerebellar ataxia, spastic paraparesis, dysarthria, and optic atrophy. Note=The disease is
    caused by mutations affecting the gene represented in this entry. MTPAP mutations result in a defect of
    mitochondrial mRNA maturation. Affected individuals exhibit a drastic decrease in poly(A) tail length of
    mitochondrial mRNA transcripts, including COX1 and RNA14 (PubMed:20970105)

  • 9 diseases for MTPAP:    About MalaCards
    ataxia, spastic, 4    optic atrophy    spastic paraparesis    spasticity
    cerebellar ataxia    ataxia    type 1 diabetes    obesity
    alzheimer's disease


    MTPAP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): MTPAP
    Human Genome Epidemiology (HuGE) Navigator: MTPAP (6 documents)

    Export disorders for MTPAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTPAP gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with MTPAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase. (PubMed id 15769737)1, 2, 3 Nagaike T.... Ueda T. (2005)
    2. Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase. (PubMed id 15547249)1, 2, 3 Tomecki R....Stepien P.P. (2004)
    3. Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. (PubMed id 21292163)1, 2 Bai Y.... Tong L. (2011)
    4. Defective mitochondrial mRNA maturation is associated with spastic ataxia. (PubMed id 20970105)1, 2 Crosby A.H....Lightowlers R.N. (2010)
    5. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. Gene regulation: reviving the message. (PubMed id 12239557)1, 3 Keller W. and Martin G. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55149 HGNC: 25532 AceView: PAPD1 Ensembl:ENSG00000107951 euGenes: HUgn55149
    ECgene: MTPAP H-InvDB: MTPAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTPAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTPAP gene:
    Search GeneIP for patents involving MTPAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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