Aliases for MTOR Gene
Aliases for MTOR Gene
- Mechanistic Target Of Rapamycin 2 3 4 5
- Rapamycin And FKBP12 Target 1 2 3 4
- Mammalian Target Of Rapamycin 2 3 4
- FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 1 3 4
- Mechanistic Target Of Rapamycin (Serine/Threonine Kinase) 2 3
- FK506 Binding Protein 12-Rapamycin Associated Protein 2 2 3
- FKBP12-Rapamycin Complex-Associated Protein 1 2 3
- Rapamycin Associated Protein FRAP2 2 3
- FKBP-Rapamycin Associated Protein 2 3
- Rapamycin Target Protein 1 3 4
- FRAP1 3 4
- FRAP2 3 4
External Ids for MTOR Gene
- HGNC: 3942
- Entrez Gene: 2475
- Ensembl: ENSG00000198793
- OMIM: 601231
- UniProtKB: P42345
Previous HGNC Symbols for MTOR Gene
- FRAP
- FRAP2
- FRAP1
Previous GeneCards Identifiers for MTOR Gene
- GC01M011089
- GC01M010317
Summaries for MTOR Gene
-
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
-
mTOR deregulation has been observed in many cancer types. As a part of the PI3K/Akt pathway, there is a broad interest in mTOR biology across cancer types. mTOR inhibition has been investigated for nearly a decade. Everolimus, temsirolimus and zotarolimus are three of the more commonly used mTOR inhibitors used in clinical treatment today, with modest success.
GeneCards Summary for MTOR Gene
MTOR (Mechanistic Target Of Rapamycin) is a Protein Coding gene. Diseases associated with MTOR include Smith-Kingsmore Syndrome and Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome. Among its related pathways are Development IGF-1 receptor signaling and Constitutive Signaling by AKT1 E17K in Cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is SMG1.
UniProtKB/Swiss-Prot for MTOR Gene
-
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser-422. Regulates osteoclastogensis by adjusting the expression of CEBPB isoforms (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTOR Gene
Genomics for MTOR Gene
Regulatory Elements for MTOR Gene
Enhancers for MTOR Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MTOR on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MTOR Gene
- Chromosome:
- 1
- Start:
- 11,106,531 bp from pter
- End:
- 11,262,557 bp from pter
- Size:
- 156,027 bases
- Orientation:
- Minus strand
Genomic View for MTOR Gene
Genes around MTOR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.22 by Ensembl
- 1p36.22 by Entrez Gene
- 1p36.22 by HGNC
MTOR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTOR Gene
Proteins for MTOR Gene
-
Protein details for MTOR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P42345-MTOR_HUMAN
- Recommended name:
- Serine/threonine-protein kinase mTOR
- Protein Accession:
- P42345
- Q4LE76
- Q5TER1
- Q6LE87
- Q96QG3
- Q9Y4I3
Protein attributes for MTOR Gene
- Size:
- 2549 amino acids
- Molecular mass:
- 288892 Da
- Quaternary structure:
-
- Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC1 complex is a 1 Md obligate dimer of two stoichiometric heterotetramers with overall dimensions of 290 A x 210 A x 135 A. It has a rhomboid shape and a central cavity, the dimeric interfaces are formed by interlocking interactions between the two MTOR and the two RPTOR subunits. The MLST8 subunit forms distal foot-like protuberances, and contacts only one MTOR within the complex, while the small PRAS40 localizes to the midsection of the central core, in close proximity to RPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with PLPP7 and PML. Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex. Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). Interacts with UBQLN1. Interacts with TTI1 and TELO2. Interacts with CLIP1; phosphorylates and regulates CLIP1. Interacts with NBN. Interacts with HTR6 (PubMed:23027611). Interacts with BRAT1.
- SequenceCaution:
-
- Sequence=AAC39933.1; Type=Frameshift; Positions=956, 999; Evidence={ECO:0000305}; Sequence=BAE06077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for MTOR Gene
Post-translational modifications for MTOR Gene
- Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation. Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and PRAS40 and leads to increased intrinsic mTORC1 kinase activity. Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity.
- Ubiquitination at posLast=309309, Lys616, posLast=12931293, posLast=16351635, Lys1655, and posLast=21662166
- Modification sites at PhosphoSitePlus
Other Protein References for MTOR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MTOR
- R&D Systems Antibodies for MTOR (TOR)
- Cell Signaling Technology (CST) Antibodies for MTOR (mTOR)
-
Custom Antibody ServicesOriGene Antibodies for MTOR
- CF806117
- TA806117
- CF806072
- TA806072
- CF806066
- TA806066
- CF805945
- TA805945
- CF805942
- TA805942
- CF805930
- TA805930
- CF805914
- TA805914
- CF805913
- TA805913
- CF805908
- TA805908
- CF805901
- TA805901
- CF805816
- TA805816
- TA590835
- TA353962
- TA352630
- TA352422
- TA333255
- TA332740
- TA325699
- TA325698
- TA325697
- TA325696
- TA322695
- TA322694
- TA310067
- R1472P
- AP55871PU-S
- AP55871PU-N
- AP33129PU-S
- AP33129PU-N
- AP20987PU-N
- AP20896PU-N
- AP20800PU-N
- AP20712PU-N
- AP15666PU-S
- AP15666PU-N
- AP15666PU-M
- AP09511PU-S
- AP09511PU-N
- AP09299PU-N
- AP08060PU-S
- AP08060PU-N
- AP07823PU-N
- AP07537PU-N
- AP07300PU-N
- AP06628PU-N
- AP06541PU-N
- AP02480PU-S
- AP02480PU-N
- TA306210
- TA302216
- TA300537
- Novus Biologicals Antibodies for MTOR
-
Abcam antibodies for MTOR
-
Cloud-Clone Corp. Antibodies for MTOR
- Invitrogen Antibodies for MTOR
- antibodies-online Antibodies for MTOR: See all 363
- GeneTex MTOR antibody for MTOR
-
Custom Antibody ServicesProSci Antibodies for MTOR
-
Santa Cruz Biotechnology (SCBT) Antibodies for MTOR
Protein Products
- EMD Millipore Purified and/or Recombinant MTOR Protein
-
OriGene Purified Proteins for MTOR
- Search Origene for MassSpec and Protein Over-expression Lysates for MTOR
- Origene Custom Protein Services for MTOR
-
Cloud-Clone Corp. Proteins for MTOR
- antibodies-online Proteins for MTOR: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MTOR
-
Abcam proteins for MTOR
Assay Products
- EMD Millipore Kits and Assays for MTOR
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for MTOR (TOR)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for MTOR (mTOR)
-
Cloud-Clone Corp Assay Kits for MTOR
- antibodies-online Kits for MTOR: See all 43
-
Abcam assays for MTOR
No data available for DME Specific Peptides for MTOR Gene
Domains & Families for MTOR Gene
Gene Families for MTOR Gene
Protein Domains for MTOR Gene
Suggested Antigen Peptide Sequences for MTOR Gene
Graphical View of Domain Structure for InterPro Entry
P42345UniProtKB/Swiss-Prot:
MTOR_HUMAN :- The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center.
- Belongs to the PI3/PI4-kinase family.
- Domain:
-
- The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center.
- The FAT domain forms three discontinuous subdomains of alpha-helical TPR repeats plus a single subdomain of HEAT repeats. The four domains pack sequentially to form a C-shaped a-solenoid that clamps onto the kinase domain (PubMed:23636326).
- Family:
-
- Belongs to the PI3/PI4-kinase family.
Function for MTOR Gene
Molecular function for MTOR Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity of mTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation and the activation of mTORC1. Activation by amino acids requires relocalization of the mTORC1 complex to lysosomes that is mediated by the Ragulator complex, SLC38A9, and the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD (PubMed:18497260, PubMed:20381137, PubMed:25561175, PubMed:25567906). On the other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits mTORC1 through a REDD1-dependent mechanism which may also require PRKAA1. The kinase activity of MTOR within the mTORC1 complex is positively regulated by MLST8 and negatively regulated by DEPTOR and AKT1S1. MTOR phosphorylates RPTOR which in turn inhibits mTORC1. MTOR is the target of the immunosuppressive and anti-cancer drug rapamycin which acts in complex with FKBP1A/FKBP12, and specifically inhibits its kinase activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. It may be regulated by RHEB but in an indirect manner through the PI3K signaling pathway.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser-422. Regulates osteoclastogensis by adjusting the expression of CEBPB isoforms (By similarity).
Enzyme Numbers (IUBMB) for MTOR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001030 | RNA polymerase III type 1 promoter DNA binding | IDA | 20233713 |
| GO:0001031 | RNA polymerase III type 2 promoter DNA binding | IDA | 20233713 |
| GO:0001032 | RNA polymerase III type 3 promoter DNA binding | IDA | 20233713 |
| GO:0001156 | TFIIIC-class transcription factor binding | IDA | 20543138 |
Phenotypes for MTOR Gene
- MGI mutant phenotypes for MTOR:
-
inferred from 16 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for MTOR:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Transferrin accumulation in the perinuclear area
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Decreased shRNA abundance
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased circadian period length
- Decreased cell number
- Decreased cell proliferation
- Increased cell migration
- Increased Nanog expression
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Decreased viability with paclitaxel
Animal Models for MTOR Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for MTOR
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTOR
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MTOR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
- Search ViGene Biosciences for MTOR
CRISPR Products
-
OriGene CRISPR knockouts for MTOR
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTOR
- GenScript: Design CRISPR guide RNA sequences for MTOR
miRNA for MTOR Gene
- miRTarBase miRNAs that target MTOR
-
- hsa-mir-99a-5p (MIRT006146)
- hsa-mir-520c-3p (MIRT006155)
- hsa-mir-373-3p (MIRT006157)
- hsa-mir-99b-5p (MIRT006564)
- mmu-mir-100-5p (MIRT006627)
- hsa-mir-144-3p (MIRT006872)
- hsa-mir-100-5p (MIRT007365)
- hsa-mir-199a-3p (MIRT026023)
- hsa-mir-16-5p (MIRT031485)
- hsa-mir-744-5p (MIRT037492)
- hsa-mir-181b-5p (MIRT047241)
- hsa-mir-101-3p (MIRT054040)
- hsa-let-7c-5p (MIRT437347)
- hsa-mir-218-5p (MIRT440200)
miRNA Products
- Search ViGene Biosciences for MTOR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MTOR
- Browse OriGene Inhibitory RNA Products For MTOR
-
ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
Clone Products
-
OriGene ORF clones in human for MTOR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MTOR
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MTOR
- VectorBuilder custom plasmid, inducible vectors for MTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MTOR
-
ViGene Biosciences adenoviral particle packaged cDNA for MTOR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MTOR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTOR Gene
Localization for MTOR Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTOR Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm. Nucleus, PML body. Microsome membrane. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). {ECO:0000250 UniProtKB:Q9JLN9, ECO:0000269 PubMed:18497260, ECO:0000269 PubMed:20381137}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| plasma membrane | 4 |
| mitochondrion | 4 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endosome | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 11853878 |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for MTOR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 3 | mTOR signalling |
.70
|
.51
|
| 4 | Glioma |
.47
.37
|
.36
|
| 5 | GAB1 signalosome |
.89
|
|
Pathways by source for MTOR Gene
5 Sino Biological pathways for MTOR Gene
2 GeneTex pathways for MTOR Gene
1 Cell Signaling Technology pathway for MTOR Gene
47 BioSystems pathways for MTOR Gene
51 Reactome pathways for MTOR Gene
1 PharmGKB pathway for MTOR Gene
29 KEGG pathways for MTOR Gene
14 GeneGo (Thomson Reuters) pathways for MTOR Gene
- Development CNTF receptor signaling
- Development Endothelin-1/EDNRA transactivation of EGFR
- Development Growth hormone signaling via PI3K/AKT and MAPK cascades
- Development IGF-1 receptor signaling
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
9 R&D Systems pathways for MTOR Gene
4 Tocris pathways for MTOR Gene
18 Qiagen pathways for MTOR Gene
Interacting Proteins for MTOR Gene
Selected Interacting proteins:
ENSP00000354558
P42345-MTOR_HUMAN
for MTOR Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for MTOR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | 20233713 |
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
| GO:0003007 | heart morphogenesis | IEA | -- |
Drugs & Compounds for MTOR Gene
(112) Drugs for MTOR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Everolimus | Approved | Pharma | inhibitor, Biomarker, Target | mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors | 1940 | |
| Temsirolimus | Approved | Pharma | Inhibition, inhibitor, Biomarker, Target | MTOR inhibitor, mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors, mTOR inhibitor; antitumor | 0 | |
| Sirolimus | Approved, Investigational | Pharma | inhibitor, Target | Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors | 1940 | |
| Pimecrolimus | Approved, Investigational | Pharma | inhibitor, Target, potentiator | 63 | ||
| Miconazole | Approved, Investigational, Vet_approved | Pharma | Antagonist, Pore Blocker | 3706 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| WYE 687 dihydrochloride |
|
1062161-90-3 |
|
|
(5) Tocris Compounds for MTOR Gene
| Compound | Action | Cas Number |
|---|---|---|
| KU 0063794 | Selective mTOR inhibitor | 938440-64-3 |
| PP 242 | Dual mTORC1/mTORC2 inhibitor | 1092351-67-1 |
| Temsirolimus | mTOR inhibitor; antitumor | 162635-04-3 |
| Torin 2 | Potent and selective mTOR inhibitor | 1223001-51-1 |
| WYE 687 dihydrochloride | Potent and selective mTOR inhibitor | 1062161-90-3 |
(37) ApexBio Compounds for MTOR Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZD2014 | Novel mTOR inhibitor | 1009298-59-2 |
| AZD8055 | MTOR inhibitor | 1009298-09-2 |
| BEZ235 (NVP-BEZ235) | PI3K/mTOR inhibitor,ATP-competitve | 915019-65-7 |
| BEZ235 Tosylate | MTOR/P13K inhibitor | 1028385-32-1 |
| Everolimus (RAD001) | MTOR inhibitor | 159351-69-6 |
| GDC-0349 | MTOR inhibitor | 1207360-89-1 |
| GDC-0980 (RG7422) | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 1032754-93-0 |
| GDC-mTOR inhibitor | MTOR inhibitor | 1207358-59-5 |
| GNE-477 | dual PI3K/mTOR inhibitor | 1032754-81-6 |
| GNE-493 | Pan-PI3K/mTOR inhibitor | 1033735-94-2 |
| GSK1059615 | PI3K and mTOR inhibitor,potent and reversible | 958852-01-2 |
| GSK2126458 | PI3K/mTOR inhibitor | 1086062-66-9 |
| INK 128 (MLN0128) | MTOR(TORC-1/-2) inhibitor,potent and selective | 1224844-38-5 |
| KU-0063794 | MTORC1 and mTORC2 inhibitor | 938440-64-3 |
| LY 303511 | MTOR inhibitor | 154447-38-8 |
| MHY1485 | mTOR activator, autophage inhibitor | 326914-06-1 |
| Nordihydroguaiaretic acid | Anti-tumor agent;lipoxygenase inhibitor | 500-38-9 |
| NVP-BGT226 | PI3K/mTOR inhibitor,selective and novel | 1245537-68-1 |
| OSI-027 | MTORC1/ mTORC2 inhibitor | 936890-98-1 |
| Palomid 529 | PI3K/Akt/mTOR inhibitor | 914913-88-5 |
| PF-04691502 | PI3K/mTOR (FRAP) inhibitor | 1013101-36-4 |
| PF-05212384 (PKI-587) | PI3Kα, PI3Kγ and mTOR inhibitor | 1197160-78-3 |
| PI-103 | Class I PI3K, mTOR and DNA-PK inhibitor | 371935-74-9 |
| PP121 | Dual inhibitor of tyrosine and phosphoinositide kinases | 1092788-83-4 |
| PP242 | MTOR inhibitor, selective and ATP-competitive | 1092351-67-1 |
| Rapamycin (Sirolimus) | Original antifungal antibiotic | 53123-88-9 |
| Ridaforolimus (Deforolimus, MK-8669) | MTOR inhibitor | 572924-54-0 |
| SAR245409 (XL765) | mTOR/PI3K inhibitor | 1349796-36-6 |
| Temsirolimus | MTOR inhibitor | 162635-04-3 |
| Torin 1 | MTOR inhibitor,potent and selective | 1222998-36-8 |
| Torin 2 | MTOR inhibitor,highly potent and selective | 1223001-51-1 |
| VS-5584 (SB2343) | MTOR/P13K inhibitor,potent and selective | 1246560-33-7 |
| WAY-600 | MTOR inhibitor | 1062159-35-6 |
| WYE-125132 (WYE-132) | ATP-competitive mTOR inhibitor, highly potent | 1144068-46-1 |
| WYE-354 | MTOR inhibitor,potent,ATP-competitive and cell-permeable | 1062169-56-5 |
| WYE-687 | MTOR inhibitor,ATP-competitive and selective | 1062161-90-3 |
| XL388 | MTOR inhibitor,highly potent and selective | 1251156-08-7 |
Transcripts for MTOR Gene
mRNA/cDNA for MTOR Gene
- (6) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (260) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MTOR Gene
CRISPR Products
-
OriGene CRISPR knockouts for MTOR
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTOR
- GenScript: Design CRISPR guide RNA sequences for MTOR
miRNA Products
- Search ViGene Biosciences for MTOR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MTOR
- Browse OriGene Inhibitory RNA Products For MTOR
-
ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
Clone Products
-
OriGene ORF clones in human for MTOR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MTOR
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MTOR
- VectorBuilder custom plasmid, inducible vectors for MTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
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| SP5: |
Expression for MTOR Gene
This gene is overexpressed in Nasal epithelium (32.3) and Bone (23.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTOR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MTOR Gene:
MTORSOURCE GeneReport for Unigene cluster for MTOR Gene:
Hs.338207mRNA Expression by UniProt/SwissProt for MTOR Gene:
P42345-MTOR_HUMAN
Tissue specificity:
Expressed in numerous tissues, with highest levels in testis.
Evidence on tissue expression from TISSUES for MTOR Gene
- Nervous system(4.9)
- Liver(4.6)
- Skin(3.8)
- Blood(3.7)
- Muscle(3.4)
- Kidney(3.2)
- Heart(3)
- Intestine(2.9)
- Lung(2.8)
- Eye(2.7)
- Pancreas(2.5)
- Lymph node(2.4)
- Bone marrow(2.2)
- Spleen(2.2)
- Thyroid gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MTOR Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
Organs:
Head and neck:
- brain
- cranial nerve
- head
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for MTOR
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTOR Gene
Orthologs for MTOR Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTOR 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MTOR 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | MTOR 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MTOR 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mtor 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mtor 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | MTOR 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MTOR 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mtor 34 |
|
||
| Str.15506 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9731 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mtor 34 35 |
|
||
| wufc22h08 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3686 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Tor 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007873 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | let-363 35 |
|
ManyToMany | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR420W 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B13948g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOR2 34 35 37 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | TOR 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.11338 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0235300 34 |
|
||
| Os.17756 34 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.1352 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.7658 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU05608 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tor2 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4144 34 |
|
- Species where no ortholog for MTOR was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for MTOR Gene
(3) SIMAP similar genes for MTOR Gene using alignment to 3 proteins:
Variants for MTOR Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs863225264 | Pathogenic, Smith-Kingsmore syndrome (SKS) [MIM:616638] | 11,130,747(-) | ACTTC(A/G)AAGCT | nc-transcript-variant, reference, missense | |
| VAR_041537 | A lung large cell carcinoma sample | ||||
| VAR_041538 | A metastatic melanoma sample | ||||
| VAR_041542 | An ovarian mucinous carcinoma sample | ||||
| VAR_041543 | A colorectal adenocarcinoma sample |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2658000 | CNV | deletion | 23128226 |
| esv3303581 | CNV | mobile element insertion | 20981092 |
| esv3427172 | CNV | insertion | 20981092 |
| esv3585215 | CNV | loss | 21293372 |
| nsv1122297 | CNV | deletion | 24896259 |
| nsv474152 | CNV | novel sequence insertion | 20440878 |
| nsv545407 | CNV | gain | 21841781 |
| nsv945769 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
0.0904% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.15;
39.04% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MTOR Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTOR Gene
Disorders for MTOR Gene
(68) MalaCards diseases for MTOR Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| smith-kingsmore syndrome |
|
|
| macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome |
|
|
| focal cortical dysplasia, taylor balloon cell type |
|
|
| glioblastoma multiforme |
|
|
| luminal breast carcinoma |
|
|
Search MTOR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MTOR_HUMAN- Smith-Kingsmore syndrome (SKS) [MIM:616638]: An autosomal dominant syndrome characterized by intellectual disability, macrocephaly, seizures, umbilical hernia, and facial dysmorphic features. {ECO:0000269 PubMed:25851998, ECO:0000269 PubMed:26542245}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for MTOR
No data available for Genatlas for MTOR Gene
Publications for MTOR Gene
- A mammalian protein targeted by G1-arresting rapamycin-receptor complex. (PMID: 8008069) Brown E.J. … Schreiber S.L. (Nature 1994) 2 3 4 22 64
- Dissecting the role of mTOR: lessons from mTOR inhibitors. (PMID: 20005306) Dowling R.J. … Sonenberg N. (Biochim. Biophys. Acta 2010) 3 22 25 64
- Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. (PMID: 19487463) Acosta-Jaquez H.A. … Fingar D.C. (Mol. Cell. Biol. 2009) 3 4 22 64
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). (PMID: 18925875) Garcia-Martinez J.M. … Alessi D.R. (Biochem. J. 2008) 3 4 22 64
- GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PMID: 12718876) Kim D.-H. … Sabatini D.M. (Mol. Cell 2003) 3 4 22 64
Products for MTOR Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MTOR
- EMD Millipore Purified and/or Recombinant MTOR Protein
- EMD Millipore Kits and Assays for MTOR
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for MTOR (TOR)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for MTOR (TOR)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MTOR
- TA300537
- TA302216
- TA306210
- AP02480PU-N
- AP02480PU-S
- AP06541PU-N
- AP06628PU-N
- AP07300PU-N
- AP07537PU-N
- AP07823PU-N
- AP08060PU-N
- AP08060PU-S
- AP09299PU-N
- AP09511PU-N
- AP09511PU-S
- AP15666PU-M
- AP15666PU-N
- AP15666PU-S
- AP20712PU-N
- AP20800PU-N
- AP20896PU-N
- AP20987PU-N
- AP33129PU-N
- AP33129PU-S
- AP55871PU-N
- AP55871PU-S
- R1472P
- TA310067
- TA322694
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- TA325696
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- TA325699
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- TA352422
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- TA590835
- TA805816
- CF805816
- TA805901
- CF805901
- TA805908
- CF805908
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- CF805913
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- CF805914
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- CF805930
- TA805942
- CF805942
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- CF805945
- TA806066
- CF806066
- TA806072
- CF806072
- TA806117
- CF806117
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MTOR
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- OriGene qPCR primer pairs for MTOR
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- OriGene ORF clones in human for MTOR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MTOR
- GenScript: Next-day shipping cDNA ORF clone for MTOR in any vector
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- GenScript: Design CRISPR guide RNA sequences for MTOR
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Cell Signaling Technology (CST) Antibodies for MTOR (mTOR)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for MTOR (mTOR)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for MTOR
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- Novus Biologicals Antibodies for MTOR
- Novus Biologicals proteins and lysates for MTOR
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for MTOR
- Abcam proteins for MTOR
- Abcam assays for MTOR
- Find your target
- Search knockout validated antibodies
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- Cloud-Clone Corp. Antibodies for MTOR
- Cloud-Clone Corp. Proteins for MTOR
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- Taconic Biosciences Mouse Models for MTOR
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MTOR
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for MTOR
- Addgene plasmids for MTOR
- antibodies-online Antibodies for MTOR: See all 363
- antibodies-online Kits for MTOR: See all 43
- antibodies-online Proteins for MTOR: See all 3
- Search antibodies-online for peptides
- GeneTex MTOR antibody for MTOR
- Search GeneTex for Proteins for MTOR
- ViGene Biosciences adenoviral particle packaged cDNA for MTOR gene
- ViGene Biosciences lentiviral particle packaged cDNA for MTOR gene
- ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
- Search ViGene Biosciences for MTOR
- Santa Cruz Biotechnology (SCBT) Antibodies for MTOR
- Search Santa Cruz Biotechnology (SCBT) for MTOR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MTOR
- Custom Antibody ServicesProSci Antibodies for MTOR
- Search for MTOR Proteins at ProSci
- Horizon Cell Lines for MTOR
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTOR
- VectorBuilder custom plasmid, inducible vectors for MTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTOR
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MTOR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer