MTOR Gene
protein-coding GIFtS: 64
GCID: GC01M011166
|
|
mechanistic target of rapamycin (serine/threonine kinase)(Previous name: FK506 binding protein 12-rapamycin associated protein 1...)
(Previous symbols: FRAP, FRAP2, FRAP1)
| |
Aliases
for MTOR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mechanistic Target Of Rapamycin (Serine/Threonine Kinase)1 2 | | FLJ448091 | | FRAP11 2 3 5 | | FK506 Binding Protein 12-Rapamycin Associated Protein 22 | | FRAP1 2 3 | | FKBP-Rapamycin Associated Protein2 | | FRAP21 2 3 | | FKBP12-Rapamycin Complex-Associated Protein 12 | | RAFT11 2 3 | | Rapamycin Associated Protein FRAP22 | | RAPT11 2 3 | | Serine/Threonine-Protein Kinase MTOR2 | | FK506 Binding Protein 12-Rapamycin Associated Protein 11 2 | | EC 2.7.11.13 | | Mammalian Target Of Rapamycin2 3 | | FKBP12-Rapamycin Complex-Associated Protein3 | | Rapamycin And FKBP12 Target 12 3 | | MTOR1 | | Rapamycin Target Protein 12 3 | | Mechanistic Target Of Rapamycin3 | | FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 12 3 | | |
Export aliases for MTOR gene to outside databasesPrevious GC identifers: GC01M011089 GC01M010317 |
Summaries
for MTOR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MTOR:
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinasesmediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the targetfor the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is locatedin an intron of this gene. (provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: MTOR_HUMAN, P42345Function: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival inresponse to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally andfunctionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulatesprotein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includesphosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activityof their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B and theinhibitor of translation initiation PDCD4. Regulates ribosome synthesis by activating RNA polymerase III-dependenttranscription through phosphorylation and inhibition of MAF1 a RNA polymerase III-repressor. In parallel to proteinsynthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 mayalso regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagythrough phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting theinteraction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of theautophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includesphosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellularprocesses including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guaninenucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'
Gene Wiki entry for MTOR (Mammalian target of rapamycin)
|
Genomic Views
for MTOR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MTOR
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTOR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTOR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36MTOR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M011166: view genomic region
(about GC identifiers)
Start:
|
11,166,588 bp from pter |
End:
|
11,322,608 bp from pter |
Size:
|
156,021 bases |
Orientation:
|
minus strand |
|
Proteins
for MTOR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTOR_HUMAN, P42345 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase mTOR Size: 2549 amino acids; 288892 Da
Subunit: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR,MAPKAP1 and DEPTOR. Interacts with PPAPDC3 and PML (By similarity). Interacts with PRR5 and RICTOR; the interaction isdirect within the mTORC2 complex (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TTI1 and TELO2(By similarity). Interacts with CLIP1; phosphorylates and regulates CLIP1 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatusmembrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein;Cytoplasmic side. Lysosome. Cytoplasm (By similarity). Nucleus, PML body (By similarity). Note=Shuttles betweencytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomesdepends on amino acid availability and RRAGA and RRAGB
Sequence caution: Sequence=AAC39933.1; Type=Frameshift; Positions=956, 999; Sequence=BAE06077.1; Type=Erroneousinitiation; Note=Translation N-terminally shortened;
6/12 PDB 3D structures from  and Proteopedia  for MTOR (see all 12):1AUE (3D)
1FAP (3D)
1NSG (3D)
2FAP (3D)
2GAQ (3D)
2NPU (3D)
Secondary accessions: Q4LE76 Q5TER1 Q6LE87 Q96QG3 Q9Y4I3Explore the universe of human proteins at neXtProt for MTOR: NX_P42345
Post-translational modifications:
Phosphorylated. Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261 promotesautophosphorylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P42345
MTOR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004949.1
ENSEMBL proteins: ENSP00000354558 ENSP00000366034 ENSP00000398745 Reactome Protein details: P42345
Human Recombinant Protein Products for MTOR:
Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17): About this table
MTOR for ontologies About GeneDecksing
MTOR Antibody Products:
Assay Products for MTOR: |
Protein
Domains /
Families
for MTOR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTOR for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry P42345ProtoNet protein and cluster: P42345 3 Blocks protein families: IPB000357 HEAT repeat IPB000403 Phosphatidylinositol 3- and 4-kinase IPB003151 PIK-related kinase
UniProtKB/Swiss-Prot: MTOR_HUMAN, P42345Similarity: Belongs to the PI3/PI4-kinase familySimilarity: Contains 1 FAT domainSimilarity: Contains 1 FATC domainSimilarity: Contains 7 HEAT repeatsSimilarity: Contains 1 PI3K/PI4K domain |
Function
for MTOR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MTOR_HUMAN, P42345Function: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival inresponse to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally andfunctionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulatesprotein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includesphosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activityof their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B and theinhibitor of translation initiation PDCD4. Regulates ribosome synthesis by activating RNA polymerase III-dependenttranscription through phosphorylation and inhibition of MAF1 a RNA polymerase III-repressor. In parallel to proteinsynthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 mayalso regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagythrough phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting theinteraction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of theautophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includesphosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellularprocesses including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guaninenucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation ofTSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity ofmTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation and theactivation of mTORC1. Activation by amino acids requires relocalization of the mTORC1 complex to lysosomes that ismediated by the Ragulator complex and the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD. On the other hand, low cellularenergy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits mTORC1 through a REDD1-dependentmechanism which may also require PRKAA1. The kinase activity of MTOR within the mTORC1 complex is positively regulatedby MLST8 and negatively regulated by DEPTOR and AKT1S1. MTOR phosphorylates RPTOR which in turn inhibits mTORC1.mTORC1 binds and is inhibited by the FKBP1A-rapamycin complex. mTORC2 is also activated by growth factors, but seemsto be nutrient-insensitive. It may be regulated by RHEB but in an indirect manner through the PI3K signaling pathway Enzyme Number (IUBMB): EC 2.7.11.11
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001030 | RNA polymerase III type 1 promoter DNA binding |
IDA | -- | | GO:0001031 | RNA polymerase III type 2 promoter DNA binding |
IDA | -- | | GO:0001032 | RNA polymerase III type 3 promoter DNA binding |
IDA | -- | | GO:0001156 | TFIIIC-class transcription factor binding |
IDA | -- | | GO:0004674 | protein serine/threonine kinase activity |
TAS | -- |
MTOR for ontologies About GeneDecksing
Phenotypes:
7 GenomeRNAi human phenotypes for MTOR:
15/16 MGI mutant phenotypes (inferred from 14 alleles ) (MGI details for Mtor) (see all 16):
MTOR for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for MTOR: Mtortm1Yam Mtortm1.1Koz Mtortm1.2Seq Mtortm1.1Clyn
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTOR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTOR
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MTOR (NM_004958) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTOR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTOR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTOR |
|
Pathways & Interactions
for MTOR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/56 super-pathways (see all 56) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | | | 2 | Signaling by FGFR | | | 3 | PIP3 activates AKT signaling | | | 4 | IRS-related events | | | 5 | Development IGF-RI signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/14 EMD Millipore Pathways for MTOR (see all 14)
2  R&D Systems Pathways for MTOR
1 
Cell Signaling Technology (CST) Pathway for MTOR
4  Tocris Bioscience Pathways for MTOR
5/14  GeneGo (Thomson Reuters) Pathways for MTOR (see all 14)
5/33  BioSystems Pathways for MTOR (see all 33)
5/45 
Reactome Pathways for MTOR (see all 45)
5/9 
Kegg Pathways (Kegg details for MTOR) (see all 9):
MTOR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTOR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/301 Interacting proteins for MTOR (P423451, 2, 3 ENSP000003545584) via UniProtKB, MINT, STRING, and/or I2D (see all 301)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RICTOR | Q6R3271, 2, 3, ENSP000003499594 | EBI-359260,EBI-1387196 MINT-7556061 MINT-6948596 MINT-7556024 MINT-8088269 MINT-8088291 MINT-6948610 MINT-7556076 MINT-8150419 I2D:
score=9 STRING: ENSP00000349959 | | MAPKAP1 | Q9BPZ72, 3, ENSP000002659604 | MINT-7556061 MINT-6948596 MINT-7556024 MINT-8088269 MINT-8088291 MINT-6948610 MINT-7556076 MINT-8150419 I2D:
score=4 STRING: ENSP00000265960 | | RPTOR | Q8N1221, 2, 3, ENSP000003072724 | EBI-359260,EBI-1567928 MINT-7556099 MINT-7222801 MINT-7556024 MINT-8088311 MINT-8150419 I2D:
score=12 STRING: ENSP00000307272 | | RPS6 | P627532, 3, ENSP000003697574 | MINT-8088269 MINT-8088291 MINT-8088311 I2D:
score=1 STRING: ENSP00000369757 | | RPL23A | P627502, 3, ENSP000003891034 | MINT-8088269 MINT-8088291 I2D:
score=1 STRING: ENSP00000389103 |
About this table
Gene Ontology (GO): 5/49 biological process terms (GO ID links to tree view) (see all 49): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001934 | positive regulation of protein phosphorylation |
IDA | -- | | GO:0001938 | positive regulation of endothelial cell proliferation |
IEA | -- | | GO:0005979 | regulation of glycogen biosynthetic process |
IEA | -- | | GO:0006109 | regulation of carbohydrate metabolic process |
-- | -- | | GO:0006468 | protein phosphorylation |
IMP | 17028174 |
MTOR for ontologies About GeneDecksing
|
Drugs & Compounds
for MTOR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MTOR for compounds About GeneDecksing
Compounds for MTOR available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| KU 0063794 | Selective mTOR inhibitor | [938440-64-3] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | Rapamycin | mTOR inhibitor; immunosuppressant | [53123-88-9] | | Torin 2 | Potent and selective mTOR inhibitor | [1223001-51-1] | | PP 121 | Dual kinase inhibitor; inhibits PI 3K family kinases | [1092788-83-4] |
4 DrugBank Compounds for MTOR About this table
10/58 Novoseek chemical compound relationships for MTOR gene (see all 58) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rapamycin |
95.4 |
609 |
20177775 (4), 14592809 (4), 16452206 (4), 19414357 (4) (see all 99) |
| everolimus |
81.9 |
37 |
20204306 (6), 16856892 (3), 17634556 (2), 20061787 (2) (see all 18) |
| temsirolimus |
78.9 |
13 |
17987219 (2), 19620795 (2), 15955899 (1), 17092282 (1) (see all 9) |
| ap 23573 |
78.5 |
4 |
16205124 (1), 19012509 (1), 17720651 (1) |
| ly294002 |
77 |
26 |
10623881 (2), 10749120 (1), 18773906 (1), 12193593 (1) (see all 21) |
| phosphatidylinositol |
70.6 |
37 |
10749120 (1), 16099944 (1), 9891068 (1), 15563472 (1) (see all 28) |
| farnesylthiosalicylic acid |
69.2 |
4 |
19838215 (1) |
| sunitinib |
65 |
2 |
17092282 (1), 19467916 (1) |
| wortmannin |
65 |
20 |
9249059 (2), 12569580 (1), 15227545 (1), 16372478 (1) (see all 15) |
| aicar |
62.2 |
6 |
17215282 (1), 19625624 (1), 19639604 (1), 19225536 (1) (see all 6) |
Search CenterWatch for drugs/clinical trials and news about MTOR
|
Transcripts
for MTOR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTOR gene: NM_004958.3 Unigene Cluster for MTOR: Mechanistic target of rapamycin (serine/threonine kinase) Hs.338207 [show with all ESTs]Unigene Representative Sequence: U889667 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361445(uc001asd.3) ENST00000376838(uc001asc.3) ENST00000473471
ENST00000490931 ENST00000455339 ENST00000495435 ENST00000476768
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTOR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTOR
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MTOR (NM_004958) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTOR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTOR |
Additional cDNA sequence: AB209995.1 AK024393.1 AK126762.1 AK302863.1 AK304273.1 BC113820.1 BC117166.1 BC127611.1 L34075.1 L35478.1 U88966.1 15 DOTS entries: DT.445446 DT.101980524 DT.86839085 DT.100793492 DT.102828329 DT.95085956 DT.121344265 DT.121344277 DT.75113724 DT.87015511 DT.91704383 DT.92430127 DT.95085957 DT.95179023 DT.206234 24/260 AceView cDNA sequences (see all 260): AW006106 AA975907 AI423563 NM_004958 CB119926 BG677234 BU629108 N64398 AI803273 AI719183 CA427353 AA766933 AW080263 CB119445 AI278203 L34075 F12955 BX282505 AL079590 BQ010420 BG057854 CA944864 AI797430 AL079589
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MTOR About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MTOR
|
Expression
for MTOR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTOR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTATCAGA
About this image
See MTOR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTOR
SOURCE GeneReport for Unigene cluster: Hs.338207
UniProtKB/Swiss-Prot: MTOR_HUMAN, P42345Tissue specificity: Expressed in numerous tissues, with highest levels in testis
SABiosciences Expression via Pathway-Focused PCR Arrays including MTOR (see all 10):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTOR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTOR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTOR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTOR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTOR |
Orthologs
for MTOR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MTOR gene from 9/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MTOR1 |
mechanistic target of rapamycin (serine/threonine kinase) |
82.3(n)
97.22(a) |
|
419455 XM_417614.3 XP_417614.3 |
lizard
(Anolis carolinensis) |
Reptilia |
MTOR6 |
-- |
95(a) |
1 ↔ 1 |
GL343615.1(137454-247550) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.97312 |
Xenopus laevis transcribed sequence with strong similarity more |
79.72(n) |
|
BJ072996.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc22h082 |
wufc22h08 |
81.32(n) |
|
324254 AI658150.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tor1 |
Target of rapamycin |
57.84(n)
56.62(a) |
|
47396 NM_080152.2 NP_524891.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
let-3636 |
Target of rapamycin homolog |
34(a) |
1 ↔ 1 |
I(5245743-5263429) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
TOR2(YKL203C)4
TOR21 |
PIK-related protein kinase and rapamycin target; subunit more4
Tor2p1 |
50.35(n)1
45.79(a)1 |
|
11(63359-55935)4
8536321, 4 NP_012719.21, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TOR1 |
FKBP12-rapamycin complex-associated protein |
51.39(n)
45.23(a) |
|
841427 NM_103891.3 NP_175425.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.177562 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.21(n) |
|
AK120473.1 |
ENSEMBL Gene Tree for MTOR (if available)
TreeFam Gene Tree for MTOR (if available) |
Paralogs
for MTOR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTOR gene
- PRKDC2
4 SIMAP similar genes for MTOR using alignment to 3 protein entries: MTOR_HUMAN (see all proteins):FRAP1 SMG1 ATR ATM
MTOR for paralogs About GeneDecksing
|
Genomic Variants
for MTOR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTOR (11166588 - 11322608 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MTOR: -- | 5/15 SABiosciences Cancer Mutation PCR Assays for MTOR (see all 15): |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTOR |
|
Disorders
/ Diseases
for MTOR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTOR for disorders About GeneDecksing
OMIM gene information: 601231
OMIM disorders: --
20/147  diseases for MTOR (see all 147): About MalaCardsalveolar soft part sarcoma skeletal muscle regeneration peutz-jeghers syndrome diffuse large b-cell lymphoma
subependymal giant cell astrocytoma perivascular epithelioid cell tumor focal cortical dysplasia renal clear cell carcinoma
b-cell lymphomas squamous cell carcinoma smooth muscle tumor anaplastic large cell lymphoma
waldenstrom macroglobulinemia clear cell renal cell carcinoma non-hodgkin lymphoma clear cell adenocarcinoma
polycystic kidney disease soft tissue sarcoma pemphigus vulgaris angiomyolipoma
20/22 diseases from the University of Copenhagen DISEASES database for MTOR (see all 22):Renal cell carcinoma Lymphangioleiomyomatosis Breast cancer Stomatitis
Malignant glioma Polycystic kidney disease Lymphoma Carcinoma
Lung cancer Leukemia Hepatocellular carcinoma Diabetes mellitus
Prostate cancer Kidney disease Sarcoma Peutz-Jeghers syndrome
Endometrial cancer Kidney angiomyolipoma Subependymal giant cell astrocytoma Angiomyolipoma
10/58 Novoseek disease relationships for MTOR gene (see all 58) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tuberous sclerosis |
80 |
22 |
18695678 (3), 19143643 (3), 14614311 (1), 16545079 (1) (see all 17) |
| cancer |
61.9 |
116 |
19166931 (5), 17041628 (4), 16404421 (4), 19738050 (4) (see all 56) |
| tumors |
59.9 |
149 |
18511708 (5), 14634209 (4), 16452206 (4), 15937108 (4) (see all 78) |
| lymphangioleiomyomatosis |
59.6 |
1 |
19143643 (1) |
| carcinoma renal cell |
53.4 |
8 |
19379082 (2), 18279068 (2), 17162089 (1), 17987219 (1) (see all 5) |
| renal cancer |
51.6 |
2 |
20364382 (1), 19165638 (1) |
| angiomyolipoma |
48.4 |
4 |
18085521 (1), 17521703 (1), 16575396 (1), 19265534 (1) |
| polycystic kidney diseases |
46.2 |
7 |
17102641 (2), 20460933 (2), 16567633 (1), 20133481 (1) |
| adpkd |
46.1 |
9 |
16567633 (2), 17102641 (2), 18845692 (1), 19421190 (1) |
| breast cancer |
43.5 |
29 |
15501954 (4), 16648488 (2), 16288304 (2), 19077306 (2) (see all 18) |
Human Genome Epidemiology (HuGE) Navigator: MTOR (19 documents)
Export disorders for MTOR gene to outside databases
|
Publications
for MTOR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTOR gene, integrated from 9 sources (see all 1325):
(articles sorted by number of sources associating them with MTOR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mammalian protein targeted by G1-arresting rapamycin-receptor complex. (PubMed id 8008069)1, 2, 3, 9 Brown E.J.... Schreiber S.L. (1994)
- GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PubMed id 12718876)1, 2, 9 Kim D.-H.... Sabatini D.M. (2003)
- Dissecting the role of mTOR: lessons from mTOR inhibi tors. (PubMed id 20005306)1, 7, 9 Dowling R.J....Sonenberg N. (2010)
- FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. (PubMed id 11930000)1, 2, 9 Desai B.N.... Schreiber S.L. (2002)
- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the growth machinery. (PubMed id 12150925)1, 2, 9 Kim D.-H.... Sabatini D.M. (2002)
- Site-specific mTOR phosphorylation promotes mTORC1-me diated signaling and cell growth. (PubMed id 19487463)1, 2, 9 Acosta-Jaquez H.A....Fingar D.C. (2009)
- The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. (PubMed id 12231510)1, 2, 9 Choi J.H....Zheng X.F. (2002)
- Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. (PubMed id 8662507)1, 2, 9 Choi J.... Clardy J. (1996)
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). (PubMed id 18925875)1, 2, 9 Garcia-Martinez J.M. and Alessi D.R. (2008)
- Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. (PubMed id 12150926)1, 2, 9 Hara K.... Yonezawa K. (2002)
|
External Searches for MTOR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTOR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTOR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTOR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTOR | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for MTOR | Genetics and Cytogenetics in Oncology and Haematology | | Wikipedia | http://en.wikipedia.org/wiki/Mammalian_target_of_rapamycin | | Target mTOR | http://www.targetmtor.com/index.jsp |
|
| | |
About This Section
| Patent Information for MTOR gene:
Search GeneIP for patents involving MTOR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTOR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MTOR | | OriGene shRNA RFP for MTOR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTOR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTOR | | | OriGene Protein Over-expression Lysate for MTOR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MTOR | | OriGene 3'-UTR Clone for MTOR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTOR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTOR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MTOR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MTOR | | OriGene Custom Protein Services for MTOR | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTOR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTOR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTOR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTOR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTOR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTOR |
| |
 |  |  |  | |
| | Antibodies & Assays for MTOR |
| | | | Tocris compounds for MTOR |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MTOR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTOR |
|  |  |  |  | | | | ThermoFisher Antibody for MTOR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTOR |
| |  | |
|
|
|
