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MTOR Gene

protein-coding   GIFtS: 69
GCID: GC01M011166

Mechanistic Target Of Rapamycin (Serine/Threonine Kinase)

(Previous name: FK506 binding protein 12-rapamycin associated protein 1)
(Previous symbols: FRAP, FRAP2, FRAP1)
  See MTOR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mechanistic Target Of Rapamycin (Serine/Threonine Kinase)1 2     RAFT12 3
FRAP11 2 3 5     RAPT12 3
FRAP1 2 3     FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 12 3
FRAP21 2 3     DJ576K7.1 (FK506 Binding Protein 12-Rapamycin Associated Protein 1)1
Mammalian Target Of Rapamycin1 2 3     FK506 Binding Protein 12-Rapamycin Associated Protein 11
Rapamycin And FKBP12 Target 11 2 3     Rapamycin Target Protein1
FK506 Binding Protein 12-Rapamycin Associated Protein 21 2     Serine/Threonine-Protein Kinase MTOR2
FKBP-Rapamycin Associated Protein1 2     EC 2.7.11.13
FKBP12-Rapamycin Complex-Associated Protein 11 2     FKBP12-Rapamycin Complex-Associated Protein3
Rapamycin Associated Protein FRAP21 2     mTOR3
Rapamycin Target Protein 12 3     Mechanistic Target Of Rapamycin3

External Ids:    HGNC: 39421   Entrez Gene: 24752   Ensembl: ENSG000001987937   OMIM: 6012315   UniProtKB: P423453   

Export aliases for MTOR gene to outside databases

Previous GC identifers: GC01M011089 GC01M010317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTOR Gene:
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases
mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the
target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene
is located in an intron of this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for MTOR Gene:
MTOR (mechanistic target of rapamycin (serine/threonine kinase)) is a protein-coding gene. Diseases associated with MTOR include paronychia, and kidney angiomyolipoma. GO annotations related to this gene include drug binding and protein serine/threonine kinase activity. An important paralog of this gene is ENSG00000261740.

UniProtKB/Swiss-Prot: MTOR_HUMAN, P42345
Function: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival
in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly
regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally
distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein
synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes
phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).
Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the
activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor
EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by
acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation,
through transcriptional enhancement of the pentose phosphate pathway which produces
5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this
function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase
III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In
parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy
homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also
negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1
at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy
through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth
factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor.
Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2
complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays
a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide
3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through
phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A
or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'

Gene Wiki entry for MTOR (Mammalian target of rapamycin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MTOR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTOR promoter sequence
   Search Chromatin IP Primers for MTOR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36

MTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTOR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M011166:  view genomic region     (about GC identifiers)

Start:
11,166,588 bp from pter      End:
11,322,608 bp from pter
Size:
156,021 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MTOR_HUMAN, P42345 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase mTOR  
Size: 2549 amino acids; 288892 Da
Subunit: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR,
AKT1S1/PRAS40 and DEPTOR. The mTORC1 complex is a 1 Md obligate dimer of two stoichiometric heterotetramers with
overall dimensions of 290 A x 210 A x 135 A. It has a rhomboid shape and a central cavity, the dimeric interfaces
are formed by interlocking interactions between the two MTOR and the two RPTOR subunits. the MLST8 subunits forms
distal foot-like protuberances, and contacts only one MTOR within the complex, while the small PRAS40 localizes
to the midsection of the central core, in close proximity to RPTOR. Part of the mammalian target of rapamycin
COmplex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with PPAPDC3 and PML.
Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex. Interacts with UBQLN1.
Interacts with TTI1 and TELO2. Interacts with CLIP1; phosphorylates and regulates CLIP1. Interacts with NBN
Sequence caution: Sequence=AAC39933.1; Type=Frameshift; Positions=956, 999; Sequence=BAE06077.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for MTOR (see all 18):
1AUE (3D)        1FAP (3D)        1NSG (3D)        2FAP (3D)        2GAQ (3D)        2NPU (3D)    
Secondary accessions: Q4LE76 Q5TER1 Q6LE87 Q96QG3 Q9Y4I3

Explore the universe of human proteins at neXtProt for MTOR: NX_P42345

Explore proteomics data for MTOR at MOPED

Post-translational modifications: 

  • Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes
    autophosphorylation. Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and
    PRAS40 and leads to increased intrinsic mTORC1 kinase activity1
  • Ubiquitination2 at Lys309, Lys616, Lys1293, Lys1635, Lys1655, Lys2166
  • Modification sites at PhosphoSitePlus

  • See MTOR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004949.1  
    ENSEMBL proteins: 
     ENSP00000366034   ENSP00000354558   ENSP00000398745  
    Reactome Protein details: P42345

    MTOR Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MTOR Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MTOR
    OriGene Protein Over-expression Lysate for MTOR
    OriGene MassSpec for MTOR
    OriGene Custom Protein Services for MTOR
    GenScript Custom Purified and Recombinant Proteins Services for MTOR
    Novus Biologicals MTOR Protein
    Novus Biologicals MTOR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MTOR 

     
    antibodies-online proteins for MTOR (3 products) 

     
    antibodies-online peptides for MTOR

    MTOR Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MTOR
    R&D Systems Antibodies for MTOR (TOR)
    Cell Signaling Technology (CST) Antibodies for MTOR 
    OriGene Antibodies for MTOR
    OriGene Custom Antibody Services for MTOR
    Novus Biologicals MTOR Antibodies
    Abcam antibodies for MTOR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for MTOR
    antibodies-online antibodies for MTOR (270 products) 

    MTOR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTOR
    R&D Systems ELISAs for MTOR (TOR)         (see all)
    GenScript Custom Assay Services for MTOR
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MTOR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MTOR 
    antibodies-online kits for MTOR (21 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: mechanistic target of rapamycin (serine/threonine kinase)
    FRAP subfamily

    Selected InterPro protein domains (see all 12):
     IPR011990 TPR-like_helical
     IPR011989 ARM-like
     IPR009076 Rapamycin-bd_dom
     IPR024585 DUF3385_TOR
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P42345

    ProtoNet protein and cluster: P42345

    3 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003151 PIK-related kinase


    UniProtKB/Swiss-Prot: MTOR_HUMAN, P42345
    Domain: The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center
    (PubMed:23636326)
    Domain: The FAT domain forms three discontinuous subdomains of alpha-helical TPR repeats plus a single subdomain
    of HEAT repeats. The four domains pack sequentially to form a C-shaped a-solenoid that clamps onto the kinase
    domain (PubMed:23636326)
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 FAT domain
    Similarity: Contains 1 FATC domain
    Similarity: Contains 32 HEAT repeats
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 16 TPR repeats


    Find genes that share domains with MTOR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTOR_HUMAN, P42345
    Function: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival
    in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly
    regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally
    distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein
    synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes
    phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).
    Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the
    activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor
    EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by
    acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation,
    through transcriptional enhancement of the pentose phosphate pathway which produces
    5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this
    function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase
    III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In
    parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy
    homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also
    negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1
    at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy
    through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth
    factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor.
    Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2
    complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays
    a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide
    3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through
    phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A
    or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation
    of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity
    of mTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation
    and the activation of mTORC1. Activation by amino acids requires relocalization of the mTORC1 complex to
    lysosomes that is mediated by the Ragulator complex and the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD. On the
    other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits
    mTORC1 through a REDD1-dependent mechanism which may also require PRKAA1. The kinase activity of MTOR within the
    mTORC1 complex is positively regulated by MLST8 and negatively regulated by DEPTOR and AKT1S1. MTOR
    phosphorylates RPTOR which in turn inhibits mTORC1. MTOR is the target of the immunosuppressive and anti-cancer
    drug rapamycin which acts in complex with FKBP1A/FKBP12, and specifically inhibits its kinase activity. mTORC2 is
    also activated by growth factors, but seems to be nutrient-insensitive. It may be regulated by RHEB but in an
    indirect manner through the PI3K signaling pathway

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001030RNA polymerase III type 1 promoter DNA binding IDA--
    GO:0001031RNA polymerase III type 2 promoter DNA binding IDA--
    GO:0001032RNA polymerase III type 3 promoter DNA binding IDA--
    GO:0001156TFIIIC-class transcription factor binding IDA--
    GO:0004674protein serine/threonine kinase activity TAS--
         
    Find genes that share ontologies with MTOR           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for MTOR:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability with pacli  Increased circadian period len 
     Increased colony dispersion (i  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         Selected MGI mutant phenotypes (inferred from 14 alleles(MGI details for Mtor) (see all 16):
     adipose tissue  behavior/neurological  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     nervous system  no phenotypic analysis  normal  renal/urinary system  respiratory system 

    Find genes that share phenotypes with MTOR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MTOR: Mtortm1Yam Mtortm1.1Koz Mtortm1.2Seq Mtortm1.1Clyn

       genOway: Develop your customized and physiologically relevant rodent model for MTOR

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTOR:
    mmu-mir-100-5p (MIRT006627), hsa-mir-181b-5p (MIRT047241), hsa-mir-744-5p (MIRT037492), hsa-mir-100-5p (MIRT007365), hsa-mir-144-3p (MIRT006872), hsa-mir-99b-5p (MIRT006564), hsa-mir-99a-5p (MIRT006146), hsa-mir-16-5p (MIRT031485)

    Block miRNA regulation of human, mouse, rat MTOR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTOR (see all 25):
    hsa-miR-579 hsa-miR-148b* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-1271 hsa-miR-4305 hsa-miR-3129-5p hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidMTOR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTOR
    Predesigned siRNA for gene silencing in human, mouse, rat MTOR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTOR

    Clone
    Products:
         
    OriGene clones in human, mouse for MTOR (see all 5)
    OriGene ORF clones in mouse, rat for MTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTOR (NM_004958)
    Sino Biological Human cDNA Clone for MTOR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTOR
    Addgene plasmids for MTOR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTOR
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTOR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTOR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTOR_HUMAN, P42345: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi
    apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral
    membrane protein; Cytoplasmic side. Lysosome. Cytoplasm (By similarity). Nucleus, PML body (By similarity).
    Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity).
    Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    golgi apparatus5
    lysosome5
    mitochondrion5
    vacuole5
    nucleus3
    plasma membrane3
    cytoskeleton2
    endosome2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA11853878
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005764lysosome IDA--

    Find genes that share ontologies with MTOR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTOR About   (see all 65)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    mTOR signaling pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Insulin signaling pathway0.32
    Translation Regulation activity of EIF4F0.44
    ErbB2/ErbB3 signaling events0.31
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    3Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    Signaling by Insulin receptor0.80
    IRS-related events0.94
    PKB-mediated events0.41
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    mTOR signalling0.39
    IRS-mediated signalling0.92
    TOR signaling0.32
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    5Endometrial cancer
    Signal transduction PTEN pathway0.45
    Acute myeloid leukemia0.40


    Find genes that share SuperPaths with MTOR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for MTOR
        Adipocytokines & Insulin Signaling
    Akt Signaling Pathway
    Notch Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MTOR (see all 18)
        FLT3 Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Interferon Pathway
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for MTOR
        Translational Control

    4 Tocris Bioscience Pathways for MTOR
        Akt Pathway
    Insulin Pathway
    TGF-beta Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MTOR (see all 14)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development CNTF receptor signaling
    Signal transduction AKT signaling
    Signal transduction PTEN pathway

    Selected BioSystems Pathways for MTOR (see all 36)
        MicroRNAs in cardiomyocyte hypertrophy
    TOR signaling
    Senescence and Autophagy
    Insulin Signaling
    ErbB signaling pathway

    2 Sino Biological Pathways for MTOR
        EGFR Signaling Pathway
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for MTOR (see all 7)
        Release of eIF4E
    HSF1-dependent transactivation
    Constitutive PI3K/AKT Signaling in Cancer
    S6K1-mediated signalling
    PIP3 activates AKT signaling


    Selected Kegg Pathways  (Kegg details for MTOR) (see all 14):
        ErbB signaling pathway
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    Insulin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTOR (see all 10): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MTOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTOR (P423451, 2, 3 ENSP000003545584) via UniProtKB, MINT, STRING, and/or I2D (see all 480)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RICTORQ6R3271, 2, 3, ENSP000003499594EBI-359260,EBI-1387196 MINT-7556061 MINT-6948596 MINT-7556024 MINT-8088269 MINT-8088291 MINT-6948610 MINT-7556076 MINT-8150419 I2D: score=9 STRING: ENSP00000349959
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 51):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IDA--
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0005979regulation of glycogen biosynthetic process IEA--
    GO:0006109regulation of carbohydrate metabolic process ----
    GO:0006468protein phosphorylation IMP17028174

    Find genes that share ontologies with MTOR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for MTOR (see all 14)     About this table
    CompoundAction CAS #
    AZD2014orally bioavailable inhibitor of the mTOR[1009298-59-2]
    AZD8055Potent, selective, and ATP-competitive mTOR inhibitor[1009298-09-2]
    Everolimus (RAD001)mTOR inhibitor, Rapamycin Sirolimus derivative, antifungal and immunosuppresant[159351-69-6]
    GDC-0349small molecule anticaner drug candidate[1207360-89-1]
    GDC-mTOR inhibitorPotent and selective ATP-competitive inhibitor of mTOR[1207358-59-5]
    GSK2126458highly potent PI3K and mTOR inhibitor[1086062-66-9]
    INK 128 (MLN0128)potent and selective inhibitor of TORC1 and TORC2[1224844-38-5]
    KU-0063794Selective inhibitor of mammalian target of rapamycin (mTOR)[938440-64-3]
    PP242Selective and ATP-competitive mTOR inhibitor[1092351-67-1]
    Rapamycin (Sirolimus)mTOR inhibitor, antifungal and immunosuppresant compound[53123-88-9]

    Browse Tocris compounds for MTOR

    4 DrugBank Compounds for MTOR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EverolimusAfinitor (see all 6)159351-69-6targetinhibitor20569080 18466433 19774211 11752352 20531964 20155724 19344392
    Sirolimus(-)-Rapamycin (see all 2)53123-88-9targetinhibitor19620795 11752352 20005306 12742462
    Temsirolimus-- 162635-04-3targetinhibitor18265991 17935273 11752352
    PimecrolimusASM 981 (see all 2)137071-32-0targetpotentiator12113647

    Selected Novoseek inferred chemical compound relationships for MTOR gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 95.4 609 20177775 (4), 14592809 (4), 16452206 (4), 19414357 (4) (see all 99)
    everolimus 81.9 37 20204306 (6), 16856892 (3), 17634556 (2), 20061787 (2) (see all 18)
    temsirolimus 78.9 13 17987219 (2), 19620795 (2), 15955899 (1), 17092282 (1) (see all 9)
    ap 23573 78.5 4 16205124 (1), 19012509 (1), 17720651 (1)
    ly294002 77 26 10623881 (2), 10749120 (1), 18773906 (1), 12193593 (1) (see all 21)
    phosphatidylinositol 70.6 37 10749120 (1), 16099944 (1), 9891068 (1), 15563472 (1) (see all 28)
    farnesylthiosalicylic acid 69.2 4 19838215 (1)
    sunitinib 65 2 17092282 (1), 19467916 (1)
    wortmannin 65 20 9249059 (2), 12569580 (1), 15227545 (1), 16372478 (1) (see all 15)
    aicar 62.2 6 17215282 (1), 19625624 (1), 19639604 (1), 19225536 (1) (see all 6)

    1 PharmGKB related drug/compound annotation for MTOR gene    About this table
    Drug/compound PharmGKB Annotation
    everolimus



    Find genes that share compounds with MTOR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for MTOR gene: 
    NM_004958.3  

    Unigene Cluster for MTOR:

    Mechanistic target of rapamycin (serine/threonine kinase)
    Hs.338207  [show with all ESTs]
    Unigene Representative Sequence: U88966
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376838(uc001asc.3) ENST00000361445(uc001asd.3) ENST00000473471
    ENST00000490931 ENST00000455339 ENST00000495435 ENST00000476768
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTOR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTOR (see all 25):
    hsa-miR-579 hsa-miR-148b* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-1271 hsa-miR-4305 hsa-miR-3129-5p hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidMTOR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MTOR
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    OriGene clones in human, mouse for MTOR (see all 5)
    OriGene ORF clones in mouse, rat for MTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTOR (NM_004958)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTOR
    Addgene plasmids for MTOR 
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    OriGene qSTAR qPCR primer pairs in human, mouse for MTOR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTOR
      QuantiTect SYBR Green Assays in human, mouse, rat MTOR
      QuantiFast Probe-based Assays in human, mouse, rat MTOR

    Additional mRNA sequence: 

    AB209995.1 AK024393.1 AK126762.1 AK302863.1 AK304273.1 BC113820.1 BC117166.1 BC127611.1 
    L34075.1 L35478.1 U88966.1 

    15 DOTS entries:

    DT.445446  DT.101980524  DT.86839085  DT.100793492  DT.102828329  DT.95085956  DT.121344265  DT.121344277 
    DT.75113724  DT.87015511  DT.91704383  DT.92430127  DT.95085957  DT.95179023  DT.206234 

    Selected AceView cDNA sequences (see all 260):

    CD370823 AA397996 CA427353 NM_004958 AL079590 BQ010420 AI624685 CB130997 
    AI719183 AA814913 AA766933 AI278203 AW080263 AL079589 BG677234 AI373566 
    CB119445 AA662936 BG057854 L35478 CA432283 BM825377 BI771714 BQ073602 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MTOR    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                                      -     -                 -                                             
    SP2:                                                                                                              -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for MTOR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MTOR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTATCAGA
    MTOR Expression
    About this image

    MTOR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTOR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.338207

    UniProtKB/Swiss-Prot: MTOR_HUMAN, P42345
    Tissue specificity: Expressed in numerous tissues, with highest levels in testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTOR (see all 10): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat
              Autophagy in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MTOR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTOR
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    QuantiFast Probe-based Assays in human, mouse, rat MTOR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTOR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MTOR gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtor1 , 5 mechanistic target of rapamycin (serine/threonine kinase)1, 5 90.38(n)1
    98.94(a)1
      4 (78.76 cM)5
    567171  NM_020009.21  NP_064393.21 
     1484486115 
    chicken
    (Gallus gallus)
    Aves MTOR1 mechanistic target of rapamycin (serine/threonine kinase) 82.3(n)
    97.22(a)
      419455  XM_417614.4  XP_417614.3 
    lizard
    (Anolis carolinensis)
    Reptilia MTOR6
    mechanistic target of rapamycin (serine/threonine ...
    95(a)
    1 ↔ 1
    GL343615.1(133163-276011)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.97312 Xenopus laevis transcribed sequence with strong similarity more 79.72(n)    BJ072996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc22h082 wufc22h08 81.32(n)   324254  AI658150.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tor1 Target of rapamycin 57.96(n)
    56.44(a)
      47396  NM_001273498.1  NP_001260427.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-3636
    Protein LET-363, isoform a (let-363) mRNA, complet...
    35(a)
    many ↔ many
    I(5245743-5263426) WBGene00002583
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOR2(YKL203C)4
    TOR21
    PIK-related protein kinase and rapamycin target; subunit more4
    TOR21
    50.55(n)1
    45.58(a)1
      11(63359-55935)4
    8536321, 4  NP_012719.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TOR1 TOR 51.91(n)
    46(a)
      841427  NM_103891.3  NP_175425.2 
    rice
    (Oryza sativa)
    Liliopsida Os.177562 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.21(n)    AK120473.1 


    ENSEMBL Gene Tree for MTOR (if available)
    TreeFam Gene Tree for MTOR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTOR gene
    ENSG000002617402  SMG12  
    3 SIMAP similar genes for MTOR using alignment to 3 protein entries:     MTOR_HUMAN (see all proteins):
    FRAP1    SMG1    ATR

    Find genes that share paralogs with MTOR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTOR (see all 3438)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0415424
    An ovarian mucinous carcinoma sample4--see VAR_0415422 M V mis40--------
    VAR_0415384
    A metastatic melanoma sample4--see VAR_0415382 M T mis40--------
    VAR_0415374
    A lung large cell carcinoma sample4--see VAR_0415372 A S mis40--------
    VAR_0415434
    A colorectal adenocarcinoma sample4--see VAR_0415432 S Y mis40--------
    VAR_0415444
    A glioblastoma multiforme sample4--see VAR_0415442 P L mis40--------
    rs347982591,2
    C--10344882(+) TGACA-/GTTGTTGA 1 -- cds10--------
    rs1113070991,2
    C--10360280(+) AATTATG/-TGTGT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs348203451,2
    C--10389375(+) TCACT-/AAACAC 1 -- int10--------
    rs2003155961,2
    C--10405324(+) CCCCCA/CAACCC 1 -- int10--------
    rs3724256681,2
    C--10431447(+) AAAAAA/-TAGAA 1 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for MTOR (11166588 - 11322608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MTOR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658000CNV Deletion23128226
    esv267860CNV Insertion20981092

    Human Gene Mutation Database (HGMD): MTOR
    Selected Site Specific Mutation Identification with PCR Assays for MTOR (see all 15):
    Cosmic IdAA Change
    12847p.A8S
    20407p.Q1866*
    71710p.F370Y
    51889p.L2220F
    20417p.S2215Y
    SeqTarget long-range PCR primers for resequencing MTOR
    DNA2.0 Custom Variant and Variant Library Synthesis for MTOR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601231    OMIM disorders: --

    12 diseases for MTOR:    
    About MalaCards
    paronychia    kidney angiomyolipoma    plasmablastic lymphoma    angiomyolipoma
    tuberous sclerosis    ewing's family of tumors    lymphangioleiomyomatosis    alexander disease
    subependymal giant cell astrocytoma    tuberous sclerosis complex    hemimegalencephaly    breast cancer

    Selected diseases from the University of Copenhagen DISEASES database for MTOR (see all 23):
    Renal cell carcinoma     Tuberous sclerosis     Lymphangioleiomyomatosis     Breast cancer
    Stomatitis     Malignant glioma     Polycystic kidney disease     Lymphoma
    Carcinoma     Lung cancer     Leukemia     Hepatocellular carcinoma
    Subependymal giant cell astrocytoma     Diabetes mellitus     Prostate cancer     Kidney disease
    Sarcoma     Peutz-Jeghers syndrome     Kidney angiomyolipoma     Endometrial cancer

    Find genes that share disorders with MTOR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MTOR gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 80 22 18695678 (3), 19143643 (3), 14614311 (1), 16545079 (1) (see all 17)
    cancer 61.9 116 19166931 (5), 17041628 (4), 16404421 (4), 19738050 (4) (see all 56)
    tumors 59.9 149 18511708 (5), 14634209 (4), 16452206 (4), 15937108 (4) (see all 78)
    lymphangioleiomyomatosis 59.6 1 19143643 (1)
    carcinoma renal cell 53.4 8 19379082 (2), 18279068 (2), 17162089 (1), 17987219 (1) (see all 5)
    renal cancer 51.6 2 20364382 (1), 19165638 (1)
    angiomyolipoma 48.4 4 18085521 (1), 17521703 (1), 16575396 (1), 19265534 (1)
    polycystic kidney diseases 46.2 7 17102641 (2), 20460933 (2), 16567633 (1), 20133481 (1)
    adpkd 46.1 9 16567633 (2), 17102641 (2), 18845692 (1), 19421190 (1)
    breast cancer 43.5 29 15501954 (4), 16648488 (2), 16288304 (2), 19077306 (2) (see all 18)

    Genetic Association Database (GAD): MTOR
    Human Genome Epidemiology (HuGE) Navigator: MTOR (19 documents)

    Export disorders for MTOR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTOR gene, integrated from 10 sources (see all 1471):
    (articles sorted by number of sources associating them with MTOR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. (PubMed id 8008069)1, 2, 3, 9 Brown E.J.... Schreiber S.L. (Nature 1994)
    2. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PubMed id 12718876)1, 2, 9 Kim D.-H.... Sabatini D.M. (Mol. Cell 2003)
    3. Dissecting the role of mTOR: lessons from mTOR inhibitors. (PubMed id 20005306)1, 7, 9 Dowling R.J....Sonenberg N. (Biochim. Biophys. Acta 2010)
    4. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. (PubMed id 11930000)1, 2, 9 Desai B.N.... Schreiber S.L. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the growth machinery. (PubMed id 12150925)1, 2, 9 Kim D.-H.... Sabatini D.M. (Cell 2002)
    6. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. (PubMed id 19164214)1, 4, 9 Hildebrandt M.A....Wu X. (J. Clin. Oncol. 2009)
    7. Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. (PubMed id 19487463)1, 2, 9 Acosta-Jaquez H.A.... Fingar D.C. (Mol. Cell. Biol. 2009)
    8. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. (PubMed id 12231510)1, 2, 9 Choi J.H....Zheng X.F. (EMBO Rep. 2002)
    9. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. (PubMed id 8662507)1, 2, 9 Choi J.... Clardy J. (Science 1996)
    10. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). (PubMed id 18925875)1, 2, 9 Garcia-Martinez J.M. and Alessi D.R. (Biochem. J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2475 HGNC: 3942 AceView: FRAP1 Ensembl:ENSG00000198793 euGenes: HUgn2475
    ECgene: MTOR Kegg: 2475 H-InvDB: MTOR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MTOR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTOR Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Mammalian_target_of_rapamycin
    Target mTORhttp://www.targetmtor.com/index.jsp

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTOR gene:
    Search GeneIP for patents involving MTOR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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