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Aliases for MTOR Gene

Aliases for MTOR Gene

  • Mechanistic Target Of Rapamycin 2 3 4
  • Mechanistic Target Of Rapamycin (Serine/Threonine Kinase) 2 3 5
  • Rapamycin And FKBP12 Target 1 2 3 4
  • Mammalian Target Of Rapamycin 2 3 4
  • FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 1 3 4
  • FK506 Binding Protein 12-Rapamycin Associated Protein 2 2 3
  • FKBP12-Rapamycin Complex-Associated Protein 1 2 3
  • Rapamycin Associated Protein FRAP2 2 3
  • FKBP-Rapamycin Associated Protein 2 3
  • Rapamycin Target Protein 1 3 4
  • FRAP1 3 4
  • FRAP2 3 4
  • RAFT1 3 4
  • RAPT1 3 4
  • FRAP 3 4
  • DJ576K7.1 (FK506 Binding Protein 12-Rapamycin Associated Protein 1) 2
  • FK506 Binding Protein 12-Rapamycin Associated Protein 1 2
  • FKBP12-Rapamycin Complex-Associated Protein 4
  • Rapamycin Target Protein 2
  • EC 2.7.11.1 4
  • MTOR 4
  • SKS 3

External Ids for MTOR Gene

Previous HGNC Symbols for MTOR Gene

  • FRAP
  • FRAP2
  • FRAP1

Previous GeneCards Identifiers for MTOR Gene

  • GC01M011089
  • GC01M010317

Summaries for MTOR Gene

Entrez Gene Summary for MTOR Gene

  • The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for MTOR Gene

MTOR (Mechanistic Target Of Rapamycin) is a Protein Coding gene. Diseases associated with MTOR include smith-kingsmore syndrome and isolated focal cortical dysplasia type iib. Among its related pathways are Endometrial cancer and Adipocytokine signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is SMG1.

UniProtKB/Swiss-Prot for MTOR Gene

  • Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser-422. Regulates osteoclastogensis by adjusting the expression of CEBPB isoforms (By similarity).

Gene Wiki entry for MTOR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTOR Gene

Genomics for MTOR Gene

Regulatory Elements for MTOR Gene

Enhancers for MTOR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTOR on UCSC Golden Path with GeneCards custom track

Promoters for MTOR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTOR on UCSC Golden Path with GeneCards custom track

Genomic Location for MTOR Gene

Chromosome:
1
Start:
11,106,531 bp from pter
End:
11,262,557 bp from pter
Size:
156,027 bases
Orientation:
Minus strand

Genomic View for MTOR Gene

Genes around MTOR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTOR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTOR Gene

Proteins for MTOR Gene

  • Protein details for MTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42345-MTOR_HUMAN
    Recommended name:
    Serine/threonine-protein kinase mTOR
    Protein Accession:
    P42345
    Secondary Accessions:
    • Q4LE76
    • Q5TER1
    • Q6LE87
    • Q96QG3
    • Q9Y4I3

    Protein attributes for MTOR Gene

    Size:
    2549 amino acids
    Molecular mass:
    288892 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC1 complex is a 1 Md obligate dimer of two stoichiometric heterotetramers with overall dimensions of 290 A x 210 A x 135 A. It has a rhomboid shape and a central cavity, the dimeric interfaces are formed by interlocking interactions between the two MTOR and the two RPTOR subunits. the MLST8 subunits forms distal foot-like protuberances, and contacts only one MTOR within the complex, while the small PRAS40 localizes to the midsection of the central core, in close proximity to RPTOR. Part of the mammalian target of rapamycin COmplex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with PLPP7 and PML. Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex. Interacts with UBQLN1. Interacts with TTI1 and TELO2. Interacts with CLIP1; phosphorylates and regulates CLIP1. Interacts with NBN. Interacts with HTR6 (PubMed:23027611). Interacts with BRAT1.
    SequenceCaution:
    • Sequence=AAC39933.1; Type=Frameshift; Positions=956, 999; Evidence={ECO:0000305}; Sequence=BAE06077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MTOR Gene

neXtProt entry for MTOR Gene

Proteomics data for MTOR Gene at MOPED

Post-translational modifications for MTOR Gene

  • Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation. Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and PRAS40 and leads to increased intrinsic mTORC1 kinase activity. Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity.
  • Ubiquitination at Lys 309, Lys 616, Lys 1293, Lys 1635, Lys 1655, and Lys 2166
  • Modification sites at PhosphoSitePlus

Other Protein References for MTOR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MTOR (mTOR)

No data available for DME Specific Peptides for MTOR Gene

Domains & Families for MTOR Gene

Gene Families for MTOR Gene

Graphical View of Domain Structure for InterPro Entry

P42345

UniProtKB/Swiss-Prot:

MTOR_HUMAN :
  • The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center.
  • Belongs to the PI3/PI4-kinase family.
  • Contains 32 HEAT repeats.
Domain:
  • The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center.
  • The FAT domain forms three discontinuous subdomains of alpha-helical TPR repeats plus a single subdomain of HEAT repeats. The four domains pack sequentially to form a C-shaped a-solenoid that clamps onto the kinase domain (PubMed:23636326).
  • Contains 1 FAT domain.
  • Contains 1 FATC domain.
  • Contains 1 PI3K/PI4K domain.
Family:
  • Belongs to the PI3/PI4-kinase family.
Similarity:
  • Contains 32 HEAT repeats.
  • Contains 16 TPR repeats.
genes like me logo Genes that share domains with MTOR: view

Function for MTOR Gene

Molecular function for MTOR Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity of mTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation and the activation of mTORC1. Activation by amino acids requires relocalization of the mTORC1 complex to lysosomes that is mediated by the Ragulator complex, SLC38A9, and the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD (PubMed:18497260, PubMed:20381137, PubMed:25561175, PubMed:25567906). On the other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits mTORC1 through a REDD1-dependent mechanism which may also require PRKAA1. The kinase activity of MTOR within the mTORC1 complex is positively regulated by MLST8 and negatively regulated by DEPTOR and AKT1S1. MTOR phosphorylates RPTOR which in turn inhibits mTORC1. MTOR is the target of the immunosuppressive and anti-cancer drug rapamycin which acts in complex with FKBP1A/FKBP12, and specifically inhibits its kinase activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. It may be regulated by RHEB but in an indirect manner through the PI3K signaling pathway.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser-422. Regulates osteoclastogensis by adjusting the expression of CEBPB isoforms (By similarity).

Enzyme Numbers (IUBMB) for MTOR Gene

Gene Ontology (GO) - Molecular Function for MTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001030 RNA polymerase III type 1 promoter DNA binding IDA 20233713
genes like me logo Genes that share ontologies with MTOR: view

Phenotypes for MTOR Gene

MGI mutant phenotypes for MTOR:
inferred from 15 alleles
GenomeRNAi human phenotypes for MTOR:
genes like me logo Genes that share phenotypes with MTOR: view

Human Phenotype Ontology for MTOR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MTOR Gene

MGI Knock Outs for MTOR:

Animal Model Products

  • Taconic Biosciences Mouse Models for MTOR

CRISPR Products

No data available for Transcription Factor Targets and HOMER Transcription for MTOR Gene

Localization for MTOR Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTOR Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm. Nucleus, PML body. Microsome membrane. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). {ECO:0000250 UniProtKB:Q9JLN9, ECO:0000269 PubMed:18497260, ECO:0000269 PubMed:20381137}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTOR Gene COMPARTMENTS Subcellular localization image for MTOR gene
Compartment Confidence
cytosol 5
lysosome 5
nucleus 5
vacuole 5
endoplasmic reticulum 4
golgi apparatus 4
mitochondrion 4
plasma membrane 4
cytoskeleton 2
endosome 2
extracellular 2

Gene Ontology (GO) - Cellular Components for MTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0012505 endomembrane system IDA 18497260
GO:0016605 colocalizes_with PML body IEA,ISS --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with MTOR: view

Pathways & Interactions for MTOR Gene

SuperPathways for MTOR Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Translation Insulin regulation of translation
3 PI3K events in ERBB4 signaling
4 mTOR signalling
5 CD28 co-stimulation
genes like me logo Genes that share pathways with MTOR: view

Pathways by source for MTOR Gene

SIGNOR curated interactions for MTOR Gene

Gene Ontology (GO) - Biological Process for MTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0003007 heart morphogenesis IEA --
GO:0005979 regulation of glycogen biosynthetic process IEA --
GO:0006109 regulation of carbohydrate metabolic process IEA --
genes like me logo Genes that share ontologies with MTOR: view

Drugs & Compounds for MTOR Gene

(98) Drugs for MTOR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Everolimus Approved Pharma inhibitor, Biomarker, Target mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 1835
Temsirolimus Approved Pharma Inhibition, inhibitor, Biomarker, Target MTOR inhibitor, mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 0
Sirolimus Approved, Investigational Pharma inhibitor, Target Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 1835
Pimecrolimus Approved, Investigational Pharma inhibitor, Target, potentiator 61
Miconazole Approved, Investigational Pharma Antagonist, Pore Blocker 3525

(20) Additional Compounds for MTOR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Compound 401
168425-64-7
PI 103 hydrochloride
371935-79-4

(5) Tocris Compounds for MTOR Gene

Compound Action Cas Number
Compound 401 Selective DNA-PK and mTOR inhibitor 168425-64-7
KU 0063794 Selective mTOR inhibitor 938440-64-3
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
PP 121 Dual kinase inhibitor; inhibits PI 3-K family kinases 1092788-83-4
Rapamycin mTOR inhibitor; immunosuppressant 53123-88-9

(20) ApexBio Compounds for MTOR Gene

Compound Action Cas Number
AZD2014 Novel mTOR inhibitor 1009298-59-2
AZD8055 MTOR inhibitor 1009298-09-2
Everolimus (RAD001) MTOR inhibitor 159351-69-6
GDC-0349 MTOR inhibitor 1207360-89-1
GDC-0980 (RG7422) Class I PI3K inhibitor for PI3Kα/β/δ/γ 1032754-93-0
GSK2126458 PI3K/mTOR inhibitor 1086062-66-9
INK 128 (MLN0128) MTOR(TORC-1/-2) inhibitor,potent and selective 1224844-38-5
KU-0063794 MTORC1 and mTORC2 inhibitor 938440-64-3
OSI-027 MTORC1/ mTORC2 inhibitor 936890-98-1
PP242 MTOR inhibitor, selective and ATP-competitive 1092351-67-1
Rapamycin (Sirolimus) Original antifungal antibiotic 53123-88-9
Ridaforolimus (Deforolimus, MK-8669) MTOR inhibitor 572924-54-0
Temsirolimus MTOR inhibitor 162635-04-3
Torin 1 MTOR inhibitor,potent and selective 1222998-36-8
Torin 2 MTOR inhibitor,highly potent and selective 1223001-51-1
WAY-600 MTOR inhibitor 1062159-35-6
WYE-125132 (WYE-132) ATP-competitive mTOR inhibitor, highly potent 1144068-46-1
WYE-354 MTOR inhibitor,potent,ATP-competitive and cell-permeable 1062169-56-5
WYE-687 MTOR inhibitor,ATP-competitive and selective 1062161-90-3
XL388 MTOR inhibitor,highly potent and selective 1251156-08-7
genes like me logo Genes that share compounds with MTOR: view

Drug Products

Transcripts for MTOR Gene

Unigene Clusters for MTOR Gene

Mechanistic target of rapamycin (serine/threonine kinase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTOR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: - - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for MTOR Gene

GeneLoc Exon Structure for
MTOR
ECgene alternative splicing isoforms for
MTOR

Expression for MTOR Gene

mRNA expression in normal human tissues for MTOR Gene

Protein differential expression in normal tissues from HIPED for MTOR Gene

This gene is overexpressed in Nasal epithelium (32.3) and Bone (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTOR Gene



SOURCE GeneReport for Unigene cluster for MTOR Gene Hs.338207

mRNA Expression by UniProt/SwissProt for MTOR Gene

P42345-MTOR_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest levels in testis.
genes like me logo Genes that share expression patterns with MTOR: view

Protein tissue co-expression partners for MTOR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTOR Gene

Orthologs for MTOR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MTOR Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia MTOR 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtor 36
  • 99 (a)
OneToOne
Mtor 16
Mtor 35
  • 90.38 (n)
  • 98.94 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MTOR 36
  • 100 (a)
OneToOne
MTOR 35
  • 99.32 (n)
  • 99.4 (a)
dog
(Canis familiaris)
Mammalia MTOR 36
  • 99 (a)
OneToOne
MTOR 35
  • 92.04 (n)
  • 99.1 (a)
cow
(Bos Taurus)
Mammalia MTOR 36
  • 100 (a)
OneToOne
MTOR 35
  • 92.3 (n)
  • 99.45 (a)
rat
(Rattus norvegicus)
Mammalia Mtor 35
  • 90.94 (n)
  • 98.9 (a)
chicken
(Gallus gallus)
Aves MTOR 36
  • 97 (a)
OneToOne
MTOR 35
  • 82.3 (n)
  • 97.22 (a)
lizard
(Anolis carolinensis)
Reptilia MTOR 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9731 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15506 35
mtor 35
  • 76.4 (n)
  • 89.32 (a)
zebrafish
(Danio rerio)
Actinopterygii mtor 36
  • 89 (a)
OneToOne
wufc22h08 35
mtor 35
  • 78.59 (n)
  • 90.85 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3686 35
fruit fly
(Drosophila melanogaster)
Insecta Tor 36
  • 56 (a)
OneToOne
Tor 35
  • 57.96 (n)
  • 56.44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007873 35
  • 57.39 (n)
  • 57.43 (a)
worm
(Caenorhabditis elegans)
Secernentea let-363 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOR2 36
  • 43 (a)
OneToMany
TOR2 38
TOR2 35
  • 50.55 (n)
  • 45.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13948g 35
  • 51.4 (n)
  • 47.03 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR420W 35
  • 52.43 (n)
  • 47.11 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11338 35
thale cress
(Arabidopsis thaliana)
eudicotyledons TOR 35
  • 51.91 (n)
  • 46 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7658 35
rice
(Oryza sativa)
Liliopsida Os05g0235300 35
  • 55.24 (n)
  • 53.04 (a)
Os.17756 35
barley
(Hordeum vulgare)
Liliopsida Hv.1352 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tor2 35
  • 51.97 (n)
  • 49.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05608 35
  • 53.97 (n)
  • 48.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4144 35
Species with no ortholog for MTOR:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MTOR Gene

ENSEMBL:
Gene Tree for MTOR (if available)
TreeFam:
Gene Tree for MTOR (if available)

Paralogs for MTOR Gene

Paralogs for MTOR Gene

(3) SIMAP similar genes for MTOR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTOR: view

Variants for MTOR Gene

Sequence variations from dbSNP and Humsavar for MTOR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_041537 A lung large cell carcinoma sample
VAR_041538 A metastatic melanoma sample
rs56164650 - 11,213,437(+) ATGCA(C/T)GAAGA nc-transcript-variant, reference, missense
rs28730685 - 11,212,472(-) TAGGG(C/T)AGCGC nc-transcript-variant, reference, missense
rs55975118 - 11,212,340(+) GTGAA(A/G)ACAGC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MTOR Gene

Variant ID Type Subtype PubMed ID
esv267860 CNV Insertion 20981092
esv2658000 CNV Deletion 23128226

Variation tolerance for MTOR Gene

Residual Variation Intolerance Score: 0.0904% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTOR Gene

HapMap Linkage Disequilibrium report
MTOR
Human Gene Mutation Database (HGMD)
MTOR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTOR Gene

Disorders for MTOR Gene

MalaCards: The human disease database

(55) MalaCards diseases for MTOR Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
smith-kingsmore syndrome
  • macrocephaly, seizures, mental retardation, umbilical hernia, and facial dysmorphism
isolated focal cortical dysplasia type iib
  • fcd type iib
isolated focal cortical dysplasia type iia
  • fcd type iia
glioblastoma multiforme
  • adult glioblastoma multiforme
subependymal giant cell astrocytoma
  • sega
- elite association - COSMIC cancer census association via MalaCards
Search MTOR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MTOR_HUMAN
  • Smith-Kingsmore syndrome (SKS) [MIM:616638]: An autosomal dominant syndrome characterized by intellectual disability, macrocephaly, seizures, umbilical hernia, and facial dysmorphic features. {ECO:0000269 PubMed:25851998, ECO:0000269 PubMed:26542245}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MTOR

Genetic Association Database (GAD)
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Human Genome Epidemiology (HuGE) Navigator
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Atlas of Genetics and Cytogenetics in Oncology and Haematology:
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No data available for Genatlas for MTOR Gene

Publications for MTOR Gene

  1. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. (PMID: 8008069) Brown E.J. … Schreiber S.L. (Nature 1994) 2 3 4 23 67
  2. Dissecting the role of mTOR: lessons from mTOR inhibitors. (PMID: 20005306) Dowling R.J. … Sonenberg N. (Biochim. Biophys. Acta 2010) 3 23 25 26
  3. [Mammalian target of rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma]. (PMID: 19620795) Shuuin T. … Karashima H. (Gan To Kagaku Ryoho 2009) 23 25 26
  4. Sunitinib, sorafenib and mTOR inhibitors in renal cancer. (PMID: 17935273) Radulovic S. … Bjelogrlic S.K. (J BUON 2007) 3 25 26
  5. The rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt-mTOR-p70S6K pathway in human medullary thyroid carcinoma cells. (PMID: 19815051) Grozinsky-Glasberg S. … Shimon I. (Mol. Cell. Endocrinol. 2010) 3 23

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