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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTO1 Gene

protein-coding   GIFtS: 53
GCID: GC06P074171

mitochondrial translation optimization 1 homolog (S. cerevisiae)

 Explore 5 diseases affiliated with
MTO1 via our new
 Human Malady Compendium 
Biological research products
for MTO1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Translation Optimization 1 Homolog (S. Cerevisiae)1 2     Protein MTO1 Homolog, Mitochondrial2
COXPD102     EC 1.1.1.408
Homolog Of Yeast Mto12     EC 6.3.58
Mitochondrial MTO1-32     

External Ids:    HGNC: 192611   Entrez Gene: 258212   Ensembl: ENSG000001352977   OMIM: 6146675   UniProtKB: Q9Y2Z23   

Export aliases for MTO1 gene to outside databases

Previous GC identifers: GC06P074129 GC06P074167 GC06P074228 GC06P071369


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTO1:
This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded
protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes
associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MTO1_HUMAN, Q9Y2Z2
Function: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in
mitochondrial tRNAs

Gene Wiki entry for MTO1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MTO1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13   Ensembl cytogenetic band:  6q13   HGNC cytogenetic band: 6q14.1

MTO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTO1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P074171:  view genomic region     (about GC identifiers)

Start:
74,171,301 bp from pter      End:
74,218,959 bp from pter
Size:
47,659 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTO1_HUMAN, Q9Y2Z2 (See protein sequence)
Recommended Name: Protein MTO1 homolog, mitochondrial precursor  
Size: 717 amino acids; 79964 Da
Cofactor: FAD (By similarity)
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=AAD27712.1; Type=Frameshift; Positions=9; Sequence=AAH05808.2; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: B3KQB5 Q5SWL2 Q5SWL3 Q5SWL4 Q8NDN7 Q8WZ57 Q96FE6 Q9BS06
Alternative splicing: 6 isoforms:  Q9Y2Z2-1   Q9Y2Z2-2   Q9Y2Z2-3   Q9Y2Z2-4   Q9Y2Z2-5   Q9Y2Z2-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTO1: NX_Q9Y2Z2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2Z2

  • 2 DME Specific Peptides for MTO1 (Q9Y2Z2)
     VIGLETH  TIRDVSL 

    MTO1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116698.1  NP_036255.2  NP_598400.1  

    ENSEMBL proteins: 
     ENSP00000402038   ENSP00000419561   ENSP00000396529   ENSP00000359328   ENSP00000428302  
     ENSP00000416397   ENSP00000359323   ENSP00000428903   ENSP00000407580   ENSP00000430660  
     ENSP00000428863   ENSP00000429595  

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    Uscn Proteins for MTO1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--


    MTO1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MTO1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013027 FAD_pyr_nucl-diS_OxRdtase
     IPR002218 GIDA-rel
     IPR020595 GIDA-rel_CS
     IPR026904 GidA-assoc_3

    Graphical View of Domain Structure for InterPro Entry Q9Y2Z2

    ProtoNet protein and cluster: Q9Y2Z2

    1 Blocks protein family: IPB002218 Glucose-inhibited division protein

    UniProtKB/Swiss-Prot: MTO1_HUMAN, Q9Y2Z2
    Similarity: Belongs to the MnmG family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MTO1_HUMAN, Q9Y2Z2
    Function: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in
    mitochondrial tRNAs

    Enzyme Numbers (IUBMB): EC 6.3.52 EC 1.1.1.402

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050660flavin adenine dinucleotide binding IEA--


    MTO1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/36 Interacting proteins for MTO1 (Q9Y2Z23 ENSP000004020384) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTPBP3Q969Y23, ENSP000003516444I2D: score=5 STRING: ENSP00000351644
    HSPD1P108093, ENSP000003400194I2D: score=2 STRING: ENSP00000340019
    KARSQ150463, ENSP000003254484I2D: score=1 STRING: ENSP00000325448
    OXSMQ9NWU13, ENSP000002807014I2D: score=1 STRING: ENSP00000280701
    TRMUO756483, ENSP000002908464I2D: score=1 STRING: ENSP00000290846
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002098tRNA wobble uridine modification ----
    GO:0008033tRNA processing ----
    GO:0055114oxidation-reduction process IEA--
    GO:0070899mitochondrial tRNA wobble uridine modification IEA--


    MTO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MTO1

    1 HMDB Compound for MTO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Search CenterWatch for drugs/clinical trials and news about MTO1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTO1 gene (3 alternative transcripts): 
    NM_001123226.1  NM_012123.3  NM_133645.2  

    Unigene Cluster for MTO1:

    Mitochondrial translation optimization 1 homolog (S. cerevisiae)
    Hs.347614  [show with all ESTs]
    Unigene Representative Sequence: NM_001123226
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000415954 ENST00000498286(uc010kav.3 uc003pgz.4 uc003pha.4)
    ENST00000442897 ENST00000370305(uc010kaw.1) ENST00000521032 ENST00000370308
    ENST00000415228 ENST00000370300(uc003pgy.4 uc003phb.4) ENST00000522205(uc003phc.1)
    ENST00000462039 ENST00000518210 ENST00000485082 ENST00000466977 ENST00000445187
    ENST00000520366 ENST00000487960 ENST00000524046 ENST00000521156

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF132937.1 AF319422.2 AF469110.1 AF469111.1 AK026073.1 AK074625.1 AK225828.1 AL833823.1 
    AY078985.1 AY078986.1 AY947715.1 AY947716.1 BC005808.2 BC011051.1 DQ656037.2 

    17 DOTS entries:

    DT.97855164  DT.455427  DT.100650931  DT.97795420  DT.100034226  DT.95234208  DT.95131199  DT.100650934 
    DT.100650932  DT.100650935  DT.100650919  DT.100872296  DT.121400859  DT.102842223  DT.121401059  DT.121401136 
    DT.121400519 

    24/204 AceView cDNA sequences (see all 204):

    BE070650 AK074625 BQ718226 AI160271 BQ002267 BX401352 BU165266 AK026073 
    BG177377 NM_133645 AY078985 BM807184 BG026018 CA309169 AU280169 AA573289 
    AA278420 BM707952 BM980628 H38254 CR605187 CA443179 AI560208 AF319422 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for MTO1 (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
    SP1:                                -     -     -                 -     -                                                                             -     -   
    SP2:                                -     -     -                 -     -                                                           -     -           -     -   
    SP3:                                -     -     -                 -     -                                                           -     -           -     -   
    SP4:                                -     -     -                 -     -     -     -     -     -                                   -     -           -     -   
    SP5:              -     -     -     -     -     -                 -     -                                                                                       

    ExUns: 14b · 14c · 14d · 14e ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c
    SP1:                                -                                       
    SP2:                                -                                       
    SP3:                                -                                       
    SP4:                                -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for MTO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGATTTGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MTO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTO1

    SOURCE GeneReport for Unigene cluster: Hs.347614

    UniProtKB/Swiss-Prot: MTO1_HUMAN, Q9Y2Z2
    Tissue specificity: Ubiquitously expressed in various tissues, but with a markedly elevated expression in tissues of
    high metabolic rates including cochlea

        SABiosciences Expression via Pathway-Focused PCR Array including MTO1: 
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MTO1 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mto11 , 5 mitochondrial translation optimization 1 homolog (S. more1, 5 84.71(n)1
    87.52(a)1
      9 (43.65 cM)5
    682911  NM_026658.21  NP_080934.21 
     784482085 
    chicken
    (Gallus gallus)
    Aves MTO11 mitochondrial translation optimization 1 homolog (S. more 70.38(n)
    73.71(a)
      772297  NM_001079764.1  NP_001073232.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTO16
    --
    59(a)
    1 ↔ 1
    GL343341.1(127486-147423)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1587821 zgc:158782 55.61(n)
    53.27(a)
      100009640  NM_001083009.1  NP_001076478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46101 , 3 CG46101 54(a)3
    57.11(n)1
    58.13(a)1
      375711  NM_137833.11  NP_611677.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F52H3.21 , 3 glucose inhibited division protein3
    Protein F52H3.21
    49(a)3
    54.26(n)1
    52.13(a)1
      II(10030934-10033118)3
    1745631  NM_063768.41  NP_496169.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTO11 Mto1p 52.15(n)
    49.13(a)
      852616   NP_011278.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G134401 glucose-inhibited division family A protein 49.79(n)
    42.08(a)
      815830  NM_126930.2  NP_178974.1 
    rice
    (Oryza sativa)
    Liliopsida Os.377622 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.94(n)    AK100099.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria mnmG6
    5-methylaminomethyl-2-thiouridine modification at ...
    47(a)
    1 ↔ 1
    Chromosome(3921767-3923656)


    ENSEMBL Gene Tree for MTO1 (if available)
    TreeFam Gene Tree for MTO1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/772 NCBI SNPs in MTO1 are shown (see all 772    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346720701,2
    C--71385746(+) AAAAA-/AAGAAAT 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs1445584461,2
    --74169632(+) GAAATG/TACTGA 3 -- us2k10--------
    rs122120881,2
    --74169716(+) cttcaC/Tcccca 3 -- us2k10--------
    rs1396938871,2
    --74169785(+) CCTCAC/TTAAAC 3 -- us2k10--------
    rs1851010351,2
    --74169813(+) TATATC/TCAGTG 3 -- us2k10--------
    rs1163750101,2
    F,--74169848(+) AGGCAG/CTGACC 3 -- us2k11Minor allele frequency- C:0.03WA 118
    rs30137281,2
    --74169952(+) gggctG/Tctggc 3 -- us2k10--------
    rs729600231,2
    C,F,--74170078(+) CAACCG/CATTCT 3 -- us2k11Minor allele frequency- C:0.07EA 120
    rs1473164841,2
    --74170120(+) TCTCT-/CTCTTTTT 3 -- us2k10--------
    rs131922201,2
    C--74170293(+) tttttC/Tttgta 3 -- us2k1 trp31Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for MTO1 (74171301 - 74218959 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MTO1: --
    Human Gene Mutation Database (HGMD): MTO1

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MTO1 for disorders           About GeneDecksing

    OMIM gene information: 614667    OMIM disorders: --

    UniProtKB/Swiss-Prot: MTO1_HUMAN, Q9Y2Z2
  • Defects in MTO1 are the cause of combined oxidative phosphorylation deficiency type 10 (COXPD10) [MIM:614702].
  • An autosomal recessive disorder resulting in variable defects of mitochondrial oxidative respiration. Affected
    individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. The severity is variable, but can
    be fatal in the most severe cases

    5 diseases for MTO1:    About MalaCards
    sensorineural hearing loss    hearing loss    diabetes mellitus    pneumonia
    malaria

    1 disease from the University of Copenhagen DISEASES database for MTO1:
    Nonsyndromic deafness
    Human Genome Epidemiology (HuGE) Navigator: MTO1 (3 documents)

    Export disorders for MTO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTO1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with MTO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation. (PubMed id 12011058)1, 2, 3 Li X.M.... Guan M.-X. (2002)
    2. Mutations of the mitochondrial-tRNA modifier MTO1 caus e hypertrophic cardiomyopathy and lactic acidosis. (PubMed id 22608499)1, 2 Ghezzi D....Zeviani M. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    6. Study of modifiers factors associated to mitochondrial mutations in individuals with hearing impairment. (PubMed id 19338775)1, 9 de Moraes V.C....Sartorato E.L. (2009)
    7. Molecular characterization of putative modulatory factors in two Spanish families with A1555G deafness. (PubMed id 18391568)1, 9 Otaegui D....Lopez de Munain A. (2008)
    8. Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3. (PubMed id 15542390)1, 9 Bykhovskaya Y....Fischel-Ghodsian N. (2004)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25821 HGNC: 19261 AceView: MTO1 Ensembl:ENSG00000135297 euGenes: HUgn25821
    ECgene: MTO1 H-InvDB: MTO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTO1 gene:
    Search GeneIP for patents involving MTO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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