Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MTNR1B Gene

protein-coding   GIFtS: 64
GCID: GC11P092705

Melatonin Receptor 1B

  See MTNR1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Melatonin Receptor 1B1 2     MT22
Mel1b Receptor2 3     Melatonin Receptor MEL1B2
FGQTL22     Melatonin Receptor Type 1B2
MEL-1B-R2     Mel-1B-R3

External Ids:    HGNC: 74641   Entrez Gene: 45442   Ensembl: ENSG000001346407   OMIM: 6008045   UniProtKB: P492863   

Export aliases for MTNR1B gene to outside databases

Previous GC identifers: GC11P095033 GC11P094210 GC11P092887 GC11P092390 GC11P092342 GC11P088793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MTNR1B Gene:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the
pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane
receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to
participate in light-dependent functions in the retina and may be involved in the neurobiological effects of
melatonin. (provided by RefSeq, Jul 2008)

GeneCards Summary for MTNR1B Gene:
MTNR1B (melatonin receptor 1B) is a protein-coding gene. Diseases associated with MTNR1B include diabetes mellitus, type 2, susceptiblity to, and gestational diabetes. GO annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1A.

UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286
Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of
melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit
adenylate cyclase activity

summary for MTNR1B Gene:
Melatonin receptors are a group of high affinity Gi/Go protein-coupled receptors, which are split into two
subtypes; MT1 and MT2. A third melatonin receptor, MT3, was proposed to exist but it has since been shown to
be the hamster homolog of human quinone reductase 2 and is therefore not considered within this GPCR
classification. MT1 and MT2 receptors are widely distributed with high concentrations found in the brain
(especially in the suprachiasmatic nucleus) and in the retina. Lower expression levels are seen in the
kidney, heart, lung and liver. Melatonin receptors regulate a variety of physiological and neuroendrocrine
functions including control of the endogenous circadian rhythm, thermoregulation and prolactin expression.
The human genes encoding MT1 and MT2 receptors are located on chromosome 4q35.1 and chromosome 11q21-22
respectively.

Gene Wiki entry for MTNR1B (Melatonin receptor 1B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTNR1B gene promoter:
         NF-1   Pbx1a   Brachyury   MIF-1   LCR-F1   AREB6   POU2F1   POU2F1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTNR1B promoter sequence
   Search Chromatin IP Primers for MTNR1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTNR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21-q22   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q21-q22

MTNR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTNR1B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P092705:  view genomic region     (about GC identifiers)

Start:
92,702,789 bp from pter      End:
92,718,232 bp from pter
Size:
15,444 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286 (See protein sequence)
Recommended Name: Melatonin receptor type 1B  
Size: 362 amino acids; 40188 Da

Explore the universe of human proteins at neXtProt for MTNR1B: NX_P49286

Explore proteomics data for MTNR1B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4

  • See MTNR1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005950.1  
    ENSEMBL proteins: 
     ENSP00000257068   ENSP00000436101   ENSP00000433573  
    Reactome Protein details: P49286

    MTNR1B Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MTNR1B Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MTNR1B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MTNR1B
    GenScript Custom Purified and Recombinant Proteins Services for MTNR1B
    Novus Biologicals MTNR1B Protein
    Novus Biologicals MTNR1B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTNR1B

     
    Search eBioscience for Proteins for MTNR1B 

    MTNR1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MTNR1B
    OriGene Custom Antibody Services for MTNR1B
    Novus Biologicals MTNR1B Antibodies
    Abcam antibodies for MTNR1B
    Cloud-Clone Corp. Antibodies for MTNR1B
    ThermoFisher Antibodies for MTNR1B
    LSBio Antibodies in human, mouse, rat for MTNR1B

    MTNR1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTNR1B
    Browse R&D Systems for biochemical assays
    GenScript MTNR1B-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTNR1B
    Cloud-Clone Corp. CLIAs for MTNR1B
    Search eBioscience for ELISAs for MTNR1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MTNR: GPCR / Class A : Melatonin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: MT2 receptor
    Melatonin receptors

    5 InterPro protein domains:
     IPR002278 Mel_1A_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000025 Melatonin_rcpt
     IPR027459 Mel_rcpt_1B
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P49286

    ProtoNet protein and cluster: P49286

    1 Blocks protein domain: IPB000025 Melatonin receptor signature

    UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with MTNR1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTR1B_HUMAN, P49286
    Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of
    melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit
    adenylate cyclase activity

         Genatlas biochemistry entry for MTNR1B:
    melatonin receptor 1B,expressed in retina and brain,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS7568007
    GO:0005515protein binding IPI--
    GO:0008502melatonin receptor activity IEA--
         
    Find genes that share ontologies with MTNR1B           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Mtnr1b):
     normal 

    Find genes that share phenotypes with MTNR1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mtnr1btm1Drw for MTNR1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTNR1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTNR1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTNR1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTNR1B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MTNR1B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MTNR1B:
    hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidMTNR1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTNR1B
    Predesigned siRNA for gene silencing in human, mouse, rat MTNR1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTNR1B

    Clone
    Products:
         
    OriGene clones in human, mouse for MTNR1B (see all 5)
    OriGene ORF clones in mouse, rat for MTNR1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTNR1B (NM_005959)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTNR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTNR1B

    Cell Line
    Products:
         
    GenScript MTNR1B-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTNR1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1B

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11180) for MTNR1B 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MTR1B_HUMAN, P49286: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7568007
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with MTNR1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MTNR1B About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Sweet Taste Signaling
    Melatonin Signaling0.72
    4Circadian entrainment
    Circadian entrainment0.40
    5Eicosanoid ligand-binding receptors
    Small Ligand GPCRs0.31


    Find genes that share SuperPaths with MTNR1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MTNR1B
        Melatonin Signaling

    2 BioSystems Pathways for MTNR1B
        GPCRs, Class A Rhodopsin-like
    Small Ligand GPCRs

    2 Reactome Pathways for MTNR1B
        G alpha (i) signalling events
    Class A/1 (Rhodopsin-like receptors)


    2 Kegg Pathways  (Kegg details for MTNR1B):
        Neuroactive ligand-receptor interaction
    Circadian entrainment

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTNR1B: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MTNR1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTNR1B (P492861, 2, 3 ENSP000002570684) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RGS20O760811, 2, 3, ENSP000002973134EBI-1188341,EBI-1052678 MINT-8087055 MINT-8087089 I2D: score=1 STRING: ENSP00000297313
    MTNR1AP480391, 2, 3, ENSP000003028114EBI-1188341,EBI-1188238 MINT-8087089 MINT-8087107 I2D: score=3 STRING: ENSP00000302811
    GNB4Q9HAV03, ENSP000002325644I2D: score=2 STRING: ENSP00000232564
    HSPA5P110213, ENSP000003241734I2D: score=2 STRING: ENSP00000324173
    ITM2CQ9NQX73, ENSP000003227304I2D: score=2 STRING: ENSP00000322730
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7568007
    GO:0007268synaptic transmission TAS7568007
    GO:0042593glucose homeostasis IMP--
    GO:0050796regulation of insulin secretion IMP--

    Find genes that share ontologies with MTNR1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MTNR1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    4-P-PDOTMT2 antagonist[134865-74-0]
    LuzindoleCompetitive melatonin MT1/MT2 antagonist[117946-91-5]
    MelatoninEndogenous hormone; agonist at MT1 and MT2[73-31-4]
    2-IodomelatoninHigh affinity melatonin agonist[93515-00-5]
    Prazosin hydrochloridealpha1 and alpha2B antagonist. MT3 antagonist[19237-84-4]

    3 DrugBank Compounds for MTNR1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ramelteon-- 196597-26-9targetmultitarget19568703 19228178 17015817 16730121 16432265 17389558 15695169 11752352 17803013 19768947 15869323 16173650 17157111
    MelatoninMEL (see all 4)73-31-4targetagonist15992934 19463840 20674373 19449447 20827520 19966183
    AgomelatineS-20098 (see all 2)138112-76-2target--15289999

    Selected IUPHAR Ligands for MTNR1B (MT2 receptor) (see all 24)    About this table
    LigandTypeActionAffinityPubmed IDs
    agomelatine
    AgonistFull agonist9.9 - 10.512764576 9618428
    LY 156735
    AgonistFull agonist10.415302228
    2-iodo-melatonin
    AgonistFull agonist9.7 - 10.312764576 9089668 9618428
    IIK7
    AgonistFull agonist10.310420436
    ramelteon
    AgonistFull agonist1015695169
    2-[125I]MLT
    AgonistFull agonist9.7 - 1012764576 9089668
    6-Cl-MLT
    AgonistFull agonist9.4 - 9.812764576 9089668 9618428
    GR 196429
    AgonistFull agonist9.7 - 9.810696085 9618428
    melatonin
    AgonistFull agonist9.4 - 9.812764576 9089668
    S24014
    AgonistPartial agonist9.612764576

    2 Novoseek inferred chemical compound relationships for MTNR1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melatonin 82.5 38 7568007 (3), 16098099 (2), 17632395 (2), 9089668 (2) (see all 19)
    glucose 20.1 7 19241057 (2), 19060907 (1), 20200315 (1), 19060908 (1)



    Find genes that share compounds with MTNR1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MTNR1B gene: 
    NM_005959.3  

    Unigene Cluster for MTNR1B:

    Melatonin receptor 1B
    Hs.569039  [show with all ESTs]
    Unigene Representative Sequence: NM_005959
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257068(uc001pdk.1) ENST00000532482 ENST00000528076
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTNR1B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MTNR1B:
    hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidMTNR1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTNR1B
    Predesigned siRNA for gene silencing in human, mouse, rat MTNR1B
    Clone
    Products:
         
    OriGene clones in human, mouse for MTNR1B (see all 5)
    OriGene ORF clones in mouse, rat for MTNR1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTNR1B (NM_005959)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTNR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTNR1B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MTNR1B
    OriGene qSTAR qPCR primer pairs in human, mouse for MTNR1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTNR1B
      QuantiTect SYBR Green Assays in human, mouse, rat MTNR1B
      QuantiFast Probe-based Assays in human, mouse, rat MTNR1B
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11180) for MTNR1B 

    Additional mRNA sequence: 

    AF467654.1 AY114100.1 AY521019.1 BC069163.1 U25341.1 

    2 DOTS entries:

    DT.102821914  DT.101963086 

    12 AceView cDNA sequences:

    BC069163 U25341 AI222420 AY521019 CN842566 NM_005959 BF725791 BV169750 
    CN835231 CN842471 CN835266 BX118886 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MTNR1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTCAGGCT
    MTNR1B Expression
    About this image

    MTNR1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTNR1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.569039

    UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286
    Tissue specificity: Expressed in retina and less in brain and hippocampus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTNR1B: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MTNR1B
    OriGene qSTAR qPCR primer pairs in human, mouse for MTNR1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTNR1B
    QuantiTect SYBR Green Assays in human, mouse, rat MTNR1B
    QuantiFast Probe-based Assays in human, mouse, rat MTNR1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MTNR1B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtnr1b1 , 5 melatonin receptor 1B1, 5 81.2(n)1
    80.91(a)1
      9 (5.15 cM)5
    2447011  NM_145712.21  NP_663758.21 
     158245285 
    chicken
    (Gallus gallus)
    Aves MTNR1B1 melatonin receptor 1B 67.6(n)
    69.36(a)
      396338  XM_417201.3  XP_417201.2 
    lizard
    (Anolis carolinensis)
    Reptilia MTNR1B6
    melatonin receptor 1B
    64(a)
    1 ↔ 1
    3(196732589-196811594)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004935091 melatonin receptor type 1B-like 68.24(n)
    70.55(a)
      100493509  XM_004920744.1  XP_004920801.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mel1c2 melatonin receptor type 1C z2.3 76.59(n)   30661  AY166825.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG303406
    --
    17(a)
    1 → many
    2R(5487414-5488716)
    worm
    (Caenorhabditis elegans)
    Secernentea npr-356
    Protein C50F7.1, isoform b
    20(a)
    1 → many
    IV(7743906-7746074) WBGene00016842


    ENSEMBL Gene Tree for MTNR1B (if available)
    TreeFam Gene Tree for MTNR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MTNR1B gene
    MTNR1A2  GPR502  
    2 SIMAP similar genes for MTNR1B using alignment to 5 protein entries:     MTR1B_HUMAN (see all proteins):
    MTNR1A    GPR50

    Find genes that share paralogs with MTNR1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MTNR1B (see all 369)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000291901,2
    C--88800673(+) AAAAAA/GCCCTC 1 -- int10--------
    rs1930462451,2
    --92572427(+) CAAGTA/TGCTGA 1 -- us2k10--------
    rs1852674801,2
    --92572680(+) TCACAC/TCAGTT 1 -- us2k10--------
    rs1135508941,2
    C,F--92572759(+) CCTAAC/TAAATA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1433989141,2
    C--92572843(+) CTTCA-/CCTC  
     TCCCTTC
    CCTCT
    1 -- us2k10--------
    rs784845301,2
    C,F--92572939(+) TCCCCC/TCTTTA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1927296241,2
    --92572968(+) ACTTAC/TGTAAA 1 -- us2k10--------
    rs1395730721,2
    C--92572979(+) ATAAC-/ATATGTA 1 -- us2k10--------
    rs1485876511,2
    --92573024(+) TTCTCA/GATACC 1 -- us2k10--------
    rs1117506041,2
    C--92573028(+) CAATAC/GCCACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTNR1B (92702789 - 92718232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MTNR1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744911CNV Deletion23290073
    nsv898173CNV Loss21882294
    esv28204CNV Gain19812545
    nsv442239CNV CNV18776908

    Human Gene Mutation Database (HGMD): MTNR1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTNR1B
    DNA2.0 Custom Variant and Variant Library Synthesis for MTNR1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600804   
    OMIM disorders: 125853  
    3 diseases for MTNR1B:    
    About MalaCards
    diabetes mellitus, type 2, susceptiblity to    gestational diabetes    sleep disorder

    1 disease from the University of Copenhagen DISEASES database for MTNR1B:
    Diabetes mellitus

    Find genes that share disorders with MTNR1B           About GenesLikeMe

    1 Novoseek inferred disease relationship for MTNR1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scoliosis idiopathic 65.8 2 17632395 (2)

    Genetic Association Database (GAD): MTNR1B
    Human Genome Epidemiology (HuGE) Navigator: MTNR1B (56 documents)

    Export disorders for MTNR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MTNR1B gene, integrated from 10 sources (see all 136):
    (articles sorted by number of sources associating them with MTNR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. (PubMed id 20200315)1, 4, 9 Andersson E.A....Hansen T. (Diabetes 2010)
    2. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. (PubMed id 7568007)1, 2, 9 Reppert S.M....Gusella J.F. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    3. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. (PubMed id 19060908)1, 4, 9 Lyssenko V....Groop L. (Nat. Genet. 2009)
    4. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. (PubMed id 19241057)1, 4, 9 RAPnn T....Ling C. (Diabetologia 2009)
    5. Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. (PubMed id 17632395)1, 4, 9 Qiu X.S....Cheng J.C. (Spine 2007)
    6. Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. (PubMed id 16098099)1, 4, 9 Ha E....Hong S.J. (J. Pineal Res. 2005)
    7. Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. (PubMed id 19533084)1, 4, 9 Reiling E....'t Hart L.M. (Diabetologia 2009)
    8. Variants in MTNR1B influence fasting glucose levels. (PubMed id 19060907)1, 4, 9 Prokopenko I....Abecasis G.R. (Nat. Genet. 2009)
    9. The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. (PubMed id 17108395)1, 4, 9 Qiu X.S....Cheng J.C. (Stud Health Technol Inform 2006)
    10. Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). (PubMed id 22508271)1, 4 Rasmussen-Torvik L.J....Pankow J.S. (Genet. Epidemiol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4544 HGNC: 7464 AceView: MTNR1B Ensembl:ENSG00000134640 euGenes: HUgn4544
    ECgene: MTNR1B Kegg: 4544 H-InvDB: MTNR1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MTNR1B Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Melatonin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MTNR1B gene:
    Search GeneIP for patents involving MTNR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant MTNR1B Protein
     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for MTNR1B (Melatonin R1B/MT2/MTNR1B)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MTNR1B   OriGene RNAi products in human, mouse, rat for MTNR1B  
     OriGene qPCR primer pairs and template standards for MTNR1B   OriGene Protein Over-expression Lysate for MTNR1B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MTNR1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for MTNR1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MTNR1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MTNR1B   OriGene Custom Protein Services for MTNR1B  

     
     
     Block miRNA regulation of human, mouse, rat MTNR1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MTNR1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTNR1B Predesigned siRNA for gene silencing in human, mouse, rat MTNR1B
     QuantiFast Probe-based Assays in human, mouse, rat MTNR1B QuantiTect SYBR Green Assays in human, mouse, rat MTNR1B
     PCR Arrays including human, mouse, rat MTNR1B Search Chromatin IP Primers for MTNR1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTNR1B  GeneGlobe Interaction Network for MTNR1B
     Regulatory tfbs in MTNR1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for MTNR1B GenScript cDNA clones with any tag delivered in your preferred vector for MTNR1B
     GenScript MTNR1B-overexpressing Cell Line for Assay CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for MTNR1B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MTNR1B antibodies
     MTNR1B proteins
     MTNR1B lysates
     Antibodies for MTNR1B
     See all of Abcam's Antibodies, Kits and Proteins for MTNR1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MTNR1B
     Antibodies for MTNR1B
     ELISAs for MTNR1B
     CLIAs for MTNR1B



     Browse ESI BIO Cell Lines and PureStem Progenitors for MTNR1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1B
     SwitchGear 3'UTR luciferase reporter plasmids for MTNR1B
     SwitchGear Promoter luciferase reporter plasmids for MTNR1B
     ThermoFisher Antibodies for MTNR1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTNR1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTNR1B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTNR1B
     LSBio Antibodies in human, mouse, rat for MTNR1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MTNR1B
      Search eBioscience for proteins for MTNR1B
      Search eBioscience for elisas for MTNR1B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MTNR1B gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4