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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTNR1B Gene

protein-coding   GIFtS: 64
GCID: GC11P092705

Melatonin Receptor 1B

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melatonin Receptor 1B1 2     MT22
Mel1b Receptor2 3     Melatonin Receptor MEL1B2
FGQTL22     Melatonin Receptor Type 1B2
MEL-1B-R2     Mel-1B-R3

External Ids:    HGNC: 74641   Entrez Gene: 45442   Ensembl: ENSG000001346407   OMIM: 6008045   UniProtKB: P492863   

Export aliases for MTNR1B gene to outside databases

Previous GC identifers: GC11P095033 GC11P094210 GC11P092887 GC11P092390 GC11P092342 GC11P088793


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTNR1B Gene:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the
pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane
receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to
participate in light-dependent functions in the retina and may be involved in the neurobiological effects of
melatonin. (provided by RefSeq, Jul 2008)

GeneCards Summary for MTNR1B Gene: 
MTNR1B (melatonin receptor 1B) is a protein-coding gene. Diseases associated with MTNR1B include scoliosis, and gestational diabetes, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1A.

UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286
Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of
melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit
adenylate cyclase activity

summary for MTNR1B Gene:
Melatonin receptors are a group of high affinity Gi/Go protein-coupled receptors, which are split into two
subtypes; MT1 and MT2. A third melatonin receptor, MT3, was proposed to exist but it has since been shown to
be the hamster homolog of human quinone reductase 2 and is therefore not considered within this GPCR
classification. MT1 and MT2 receptors are widely distributed with high concentrations found in the brain
(especially in the suprachiasmatic nucleus) and in the retina. Lower expression levels are seen in the
kidney, heart, lung and liver. Melatonin receptors regulate a variety of physiological and neuroendrocrine
functions including control of the endogenous circadian rhythm, thermoregulation and prolactin expression.
The human genes encoding MT1 and MT2 receptors are located on chromosome 4q35.1 and chromosome 11q21-22
respectively.

Gene Wiki entry for MTNR1B (Melatonin receptor 1B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTNR1B gene promoter:
         NF-1   Pbx1a   Brachyury   MIF-1   LCR-F1   AREB6   POU2F1   POU2F1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTNR1B promoter sequence
   Search SABiosciences Chromatin IP Primers for MTNR1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTNR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21-q22   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q21-q22

MTNR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTNR1B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P092705:  view genomic region     (about GC identifiers)

Start:
92,702,789 bp from pter      End:
92,718,232 bp from pter
Size:
15,444 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286 (See protein sequence)
Recommended Name: Melatonin receptor type 1B  
Size: 362 amino acids; 40188 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for MTNR1B: NX_P49286

Explore proteomics data for MTNR1B at MOPED 

MTNR1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MTNR1B Protein Expression

REFSEQ proteins: NP_005950.1  
ENSEMBL proteins: 
 ENSP00000257068   ENSP00000436101   ENSP00000433573  
Reactome Protein details: P49286
Human Recombinant Protein Products for MTNR1B: 
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Cloud-Clone Corp. Proteins for MTNR1B 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS7568007
GO:0016021integral to membrane ----

MTNR1B for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for MTNR1B


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
MTNR: GPCR / Class A : Melatonin receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: MT2 receptor 
Melatonin receptors

5 InterPro protein domains:
 IPR002278 Mel_1A_rcpt
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000025 Melatonin_rcpt
 IPR027459 Mel_rcpt_1B
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P49286

ProtoNet protein and cluster: P49286

1 Blocks protein domain: IPB000025 Melatonin receptor signature

UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286
Similarity: Belongs to the G-protein coupled receptor 1 family


MTNR1B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MTR1B_HUMAN, P49286
Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of
melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit
adenylate cyclase activity

     Genatlas biochemistry entry for MTNR1B:
melatonin receptor 1B,expressed in retina and brain,G protein coupled receptor superfamily

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity TAS7568007
GO:0005515protein binding IPI--
GO:0008502melatonin receptor activity IEA--
     
MTNR1B for ontologies           About GeneDecksing


Phenotypes:
     1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Mtnr1b):
 normal 

MTNR1B for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for MTNR1B: Mtnr1btm1Drw Mtnr1btm1Lex

   inGenious Targeting Laboratory - Custom generated mouse model solutions for MTNR1B 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTNR1B 
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidMTNR1B 3' UTR sequence
Inhib. RNA
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1B


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MTNR1B About                                                                                                See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
GPCRs, Class A Rhodopsin-like0.41
GPCR ligand binding0.71
Neuroactive ligand-receptor interaction0.37
G alpha (i) signalling events0.46
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Sweet Taste Signaling
Melatonin Signaling0.72
4Prostanoid ligand receptors
Small Ligand GPCRs0.40
5Circadian entrainment
Circadian entrainment0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MTNR1B
    Melatonin Signaling

2 BioSystems Pathways for MTNR1B
    GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs

5/6        Reactome Pathways for MTNR1B (see all 6)
    GPCR downstream signaling
Signal Transduction
Signaling by GPCR
G alpha (i) signalling events
GPCR ligand binding


2         Kegg Pathways  (Kegg details for MTNR1B):
    Neuroactive ligand-receptor interaction
Circadian entrainment


MTNR1B for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTNR1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/162 Interacting proteins for MTNR1B (P492862, 3 ENSP000002570684) via UniProtKB, MINT, STRING, and/or I2D (see all 162)
InteractantInteraction Details
GeneCardExternal ID(s)
RGS20O760812, 3, ENSP000002973134MINT-8087055 MINT-8087089 I2D: score=1 STRING: ENSP00000297313
MTNR1AP480392, 3, ENSP000003028114MINT-8087089 MINT-8087107 I2D: score=3 STRING: ENSP00000302811
GNB4Q9HAV03, ENSP000002325644I2D: score=2 STRING: ENSP00000232564
HSPA5P110213, ENSP000003241734I2D: score=2 STRING: ENSP00000324173
ITM2CQ9NQX73, ENSP000003227304I2D: score=2 STRING: ENSP00000322730
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7568007
GO:0007268synaptic transmission TAS7568007
GO:0042593glucose homeostasis IMP--
GO:0050796regulation of insulin secretion IMP--

MTNR1B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MTNR1B for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for MTNR1B available from Tocris Bioscience    About this table
CompoundAction CAS #
4-P-PDOTMT2 antagonist[134865-74-0]
LuzindoleCompetitive melatonin MT1/MT2 antagonist[117946-91-5]
MelatoninEndogenous hormone; agonist at MT1 and MT2[73-31-4]
2-IodomelatoninHigh affinity melatonin agonist[93515-00-5]
Prazosin hydrochloridealpha1 and alpha2B antagonist. MT3 antagonist[19237-84-4]

3 DrugBank Compounds for MTNR1B    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Ramelteon-- 196597-26-9targetmultitarget19568703 19228178 17015817 16730121 16432265 17389558 15695169 11752352 17803013 19768947 15869323 16173650 17157111
MelatoninMEL (see all 4)73-31-4targetagonist15992934 19463840 20674373 19449447 20827520 19966183
AgomelatineS-20098 (see all 2)138112-76-2target--15289999

10/24 IUPHAR Ligands for MTNR1B (MT2 receptor) (see all 24)    About this table 
LigandTypeActionAffinityPubmed IDs
agomelatine
AgonistFull agonist9.9 - 10.512764576 9618428
LY 156735
AgonistFull agonist10.415302228
2-iodo-melatonin
AgonistFull agonist9.7 - 10.312764576 9089668 9618428
IIK7
AgonistFull agonist10.310420436
ramelteon
AgonistFull agonist1015695169
2-[125I]MLT
AgonistFull agonist9.7 - 1012764576 9089668
6-Cl-MLT
AgonistFull agonist9.4 - 9.812764576 9089668 9618428
GR 196429
AgonistFull agonist9.7 - 9.810696085 9618428
melatonin
AgonistFull agonist9.4 - 9.812764576 9089668
S24014
AgonistPartial agonist9.612764576

2 Novoseek inferred chemical compound relationships for MTNR1B gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
melatonin 82.5 38 7568007 (3), 16098099 (2), 17632395 (2), 9089668 (2) (see all 19)
glucose 20.1 7 19241057 (2), 19060907 (1), 20200315 (1), 19060908 (1)

Search CenterWatch for drugs/clinical trials and news about MTNR1B / MTR1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MTNR1B gene: 
NM_005959.3  

Unigene Cluster for MTNR1B:

Melatonin receptor 1B
Hs.569039  [show with all ESTs]
Unigene Representative Sequence: NM_005959
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000257068(uc001pdk.1) ENST00000532482 ENST00000528076

miRNA
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Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: MTNR1B (NM_005959)
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Additional mRNA sequence: 

AF467654.1 AY114100.1 AY521019.1 BC069163.1 U25341.1 

2 DOTS entries:

DT.102821914  DT.101963086 

12 AceView cDNA sequences:

AY521019 CN842566 BC069163 U25341 AI222420 BV169750 NM_005959 BF725791 
CN835231 CN835266 CN842471 BX118886 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MTNR1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTTCAGGCT
MTNR1B Expression
About this image


See MTNR1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTNR1B

SOURCE GeneReport for Unigene cluster: Hs.569039

UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286
Tissue specificity: Expressed in retina and less in brain and hippocampus

    SABiosciences Expression via Pathway-Focused PCR Arrays including MTNR1B: 
          G Protein Coupled Receptors 384HT in human mouse rat
          Circadian Rhythms in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTNR1B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MTNR1B gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mtnr1b1 , 5 melatonin receptor 1B1, 5 81.2(n)1
80.91(a)1
  9 (5.15 cM)5
2447011  NM_145712.21  NP_663758.21 
 158245285 
chicken
(Gallus gallus)
Aves MTNR1B1 melatonin receptor 1B 68.77(n)
70.69(a)
  396338  XM_417201.2  XP_417201.2 
lizard
(Anolis carolinensis)
Reptilia MTNR1B6
Uncharacterized protein
66(a)
1 ↔ 1
3(196732589-196811594)
zebrafish
(Danio rerio)
Actinopterygii mel1c2 melatonin receptor type 1C z2.3 76.59(n)   30661  AY166825.1 
fruit fly
(Drosophila melanogaster)
Insecta CG303406
--
16(a)
1 → many
2R(5487414-5488716)


ENSEMBL Gene Tree for MTNR1B (if available)
TreeFam Gene Tree for MTNR1B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MTNR1B gene
MTNR1A2  GPR502  
2 SIMAP similar genes for MTNR1B using alignment to 5 protein entries:     MTR1B_HUMAN (see all proteins):
MTNR1A    GPR50

MTNR1B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/369 SNPs in MTNR1B are shown (see all 369)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0092634
----see VAR_0092632 L F mis40--------
rs2000291901,2
C--88800673(+) AAAAAA/GCCCTC 1 -- int10--------
rs1930462451,2
--92572427(+) CAAGTA/TGCTGA 1 -- us2k10--------
rs1852674801,2
--92572680(+) TCACAC/TCAGTT 1 -- us2k10--------
rs1135508941,2
C,F--92572759(+) CCTAAC/TAAATA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1433989141,2
C--92572843(+) CTTCA-/CCTC  
 TCCCTTC
CCTCT
1 -- us2k10--------
rs784845301,2
C,F--92572939(+) TCCCCC/TCTTTA 1 -- us2k11Minor allele frequency- T:0.02WA 118
rs1927296241,2
--92572968(+) ACTTAC/TGTAAA 1 -- us2k10--------
rs1395730721,2
C--92572979(+) ATAAC-/ATATGTA 1 -- us2k10--------
rs1485876511,2
--92573024(+) TTCTCA/GATACC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MTNR1B (92702789 - 92718232 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MTNR1B:    About this table     
Variant IDTypeSubtypePubMed ID
esv2744911CNV Deletion23290073
nsv898173CNV Loss21882294
esv28204CNV Gain19812545
nsv442239CNV CNV18776908


Human Gene Mutation Database (HGMD): MTNR1B
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 600804    OMIM disorders: --

20/21 diseases for MTNR1B (see all 21):    About MalaCards
scoliosis    gestational diabetes    sleep disorder    tardive dyskinesia
autism spectrum disorder    pertussis    glucose intolerance    polycystic ovary syndrome
atherosclerosis    obesity    schizophrenia    diabetes mellitus
rheumatoid arthritis    arthritis    alzheimer's disease    multiple sclerosis
melanoma    colorectal cancer    pancreatitis    breast cancer

1 disease from the University of Copenhagen DISEASES database for MTNR1B:
Diabetes mellitus

MTNR1B for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

1 Novoseek inferred disease relationship for MTNR1B gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
scoliosis idiopathic 65.8 2 17632395 (2)

Genetic Association Database (GAD): MTNR1B
Human Genome Epidemiology (HuGE) Navigator: MTNR1B (56 documents)

Export disorders for MTNR1B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MTNR1B gene, integrated from 9 sources (see all 133):
(articles sorted by number of sources associating them with MTNR1B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. MTNR1B G24E variant associates With BMI and fasting p lasma glucose in the general population in studies of 22,142 Europeans. (PubMed id 20200315)1, 4, 9 Andersson E.A....Hansen T. (2010)
  2. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. (PubMed id 7568007)1, 2, 9 Reppert S.M....Gusella J.F. (1995)
  3. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. (PubMed id 19060908)1, 4, 9 Lyssenko V....Groop L. (2009)
  4. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. (PubMed id 19241057)1, 4, 9 RAPnn T....Ling C. (2009)
  5. Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. (PubMed id 17632395)1, 4, 9 Qiu X.S....Cheng J.C. (2007)
  6. Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. (PubMed id 16098099)1, 4, 9 Ha E....Hong S.J. (2005)
  7. Combined effects of single-nucleotide polymorphisms i n GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes ris k. (PubMed id 19533084)1, 4, 9 Reiling E....'t Hart L.M. (2009)
  8. Variants in MTNR1B influence fasting glucose levels. (PubMed id 19060907)1, 4, 9 Prokopenko I....Abecasis G.R. (2009)
  9. The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. (PubMed id 17108395)1, 4, 9 Qiu X.S....Cheng J.C. (2006)
  10. Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). (PubMed id 22508271)1, 4 Rasmussen-Torvik L.J....Pankow J.S. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 4544 HGNC: 7464 AceView: MTNR1B Ensembl:ENSG00000134640 euGenes: HUgn4544
ECgene: MTNR1B Kegg: 4544 H-InvDB: MTNR1B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MTNR1B Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Melatonin_receptor

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MTNR1B gene:
Search GeneIP for patents involving MTNR1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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