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Aliases for MTNR1B Gene

Aliases for MTNR1B Gene

  • Melatonin Receptor 1B 2 3
  • Mel1b Receptor 3 4
  • MEL-1B-R 3 4
  • Melatonin Receptor Type 1B 3
  • Melatonin Receptor MEL1B 3
  • FGQTL2 3
  • MT2 3

External Ids for MTNR1B Gene

Summaries for MTNR1B Gene

Entrez Gene Summary for MTNR1B Gene

  • This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTNR1B Gene

MTNR1B (Melatonin Receptor 1B) is a Protein Coding gene. Diseases associated with MTNR1B include idiopathic scoliosis and scoliosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is GPR50.

UniProtKB/Swiss-Prot for MTNR1B Gene

  • High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity

Tocris Summary for MTNR1B Gene

  • Melatonin receptors are a group of high affinity Gi/Go protein-coupled receptors, which are split into two subtypes; MT1 and MT2. A third melatonin receptor, MT3, was proposed to exist but it has since been shown to be the hamster homolog of human quinone reductase 2 and is therefore not considered within this GPCR classification. MT1 and MT2 receptors are widely distributed with high concentrations found in the brain (especially in the suprachiasmatic nucleus) and in the retina. Lower expression levels are seen in the kidney, heart, lung and liver. Melatonin receptors regulate a variety of physiological and neuroendrocrine functions including control of the endogenous circadian rhythm, thermoregulation and prolactin expression. The human genes encoding MT1 and MT2 receptors are located on chromosome 4q35.1 and chromosome 11q21-22 respectively.

Gene Wiki entry for MTNR1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTNR1B Gene

Genomics for MTNR1B Gene

Genomic Location for MTNR1B Gene

Start:
92,969,623 bp from pter
End:
92,985,066 bp from pter
Size:
15,444 bases
Orientation:
Plus strand

Genomic View for MTNR1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTNR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTNR1B Gene

Regulatory Elements for MTNR1B Gene

Proteins for MTNR1B Gene

  • Protein details for MTNR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49286-MTR1B_HUMAN
    Recommended name:
    Melatonin receptor type 1B
    Protein Accession:
    P49286
    Secondary Accessions:

    Protein attributes for MTNR1B Gene

    Size:
    362 amino acids
    Molecular mass:
    40188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTNR1B Gene

Proteomics data for MTNR1B Gene at MOPED

Post-translational modifications for MTNR1B Gene

Other Protein References for MTNR1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MTNR1B Gene

Domains for MTNR1B Gene

Gene Families for MTNR1B Gene

HGNC:
  • MTNR :GPCR / Class A : Melatonin receptors
IUPHAR :

Protein Domains for MTNR1B Gene

UniProtKB/Swiss-Prot:

MTR1B_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P49286
genes like me logo Genes that share domains with MTNR1B: view

Function for MTNR1B Gene

Molecular function for MTNR1B Gene

GENATLAS Biochemistry: melatonin receptor 1B,expressed in retina and brain,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity

Gene Ontology (GO) - Molecular Function for MTNR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 7568007
GO:0005515 protein binding IPI 20859254
GO:0008502 melatonin receptor activity IEA --
genes like me logo Genes that share ontologies with MTNR1B: view

Phenotypes for MTNR1B Gene

MGI mutant phenotypes for MTNR1B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MTNR1B: view

Animal Models for MTNR1B Gene

MGI Knock Outs for MTNR1B:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MTNR1B Gene

Localization for MTNR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTNR1B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTNR1B Gene COMPARTMENTS Subcellular localization image for MTNR1B gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MTNR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7568007
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with MTNR1B: view

Pathways for MTNR1B Gene

genes like me logo Genes that share pathways with MTNR1B: view

Pathways by source for MTNR1B Gene

Gene Ontology (GO) - Biological Process for MTNR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7568007
GO:0007268 synaptic transmission TAS 7568007
GO:0042593 glucose homeostasis IMP 20668700
GO:0050796 regulation of insulin secretion IMP 20668700
genes like me logo Genes that share ontologies with MTNR1B: view

Compounds for MTNR1B Gene

(5) Tocris Compounds for MTNR1B Gene

Compound Action Cas Number
2-Iodomelatonin High affinity melatonin agonist [93515-00-5]
4-P-PDOT MT2 antagonist [134865-74-0]
Luzindole Competitive melatonin MT1/MT2 antagonist [117946-91-5]
Melatonin Endogenous hormone; agonist at MT1 and MT2 [73-31-4]
Prazosin hydrochloride alpha1 and alpha2B antagonist. MT3 antagonist [19237-84-4]

(3) Drugbank Compounds for MTNR1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Agomelatine
  • S-20098
138112-76-2 target
Melatonin
  • MEL
73-31-4 target agonist
Ramelteon
196597-26-9 target multitarget

(24) IUPHAR Ligand for MTNR1B Gene

Ligand Type Action Affinity Pubmed IDs
2-iodo-melatonin Agonist Full agonist 11
ramelteon Agonist Full agonist 10.9
2-[125I]MLT Agonist Full agonist 10.7
LY 156735 Agonist Full agonist 10.1
GR 196429 Agonist Full agonist 9.9
[3H]melatonin Agonist Full agonist 9.9
5-methoxy-luzindole Agonist Partial agonist 9.6
S26131 Antagonist Antagonist 9.3
6-Cl-MLT Agonist Full agonist 9.2
6-hydroxymelatonin Agonist Full agonist 9.2
S26284 Agonist Partial agonist 9.2
IIK7 Agonist Full agonist 8.3
S22153 Antagonist Antagonist 8.1
DH97 Antagonist Antagonist 8
5-HEAT Agonist Full agonist 7.8
S24014 Agonist Partial agonist 7.5
K185 Antagonist Antagonist 7.2
4P-PDOT Antagonist Antagonist 7.2
S24773 Agonist Full agonist 7.1
GR 128107 Agonist Partial agonist 6.9
S20928 Antagonist Antagonist 6.9
luzindole Antagonist Antagonist 6.8
agomelatine Antagonist Antagonist 6.2
melatonin Antagonist Antagonist 5.2

(2) Novoseek inferred chemical compound relationships for MTNR1B Gene

Compound -log(P) Hits PubMed IDs
melatonin 82.5 25
glucose 20.1 5
genes like me logo Genes that share compounds with MTNR1B: view

Transcripts for MTNR1B Gene

mRNA/cDNA for MTNR1B Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTNR1B Gene

Melatonin receptor 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTNR1B Gene

No ASD Table

Relevant External Links for MTNR1B Gene

GeneLoc Exon Structure for
MTNR1B
ECgene alternative splicing isoforms for
MTNR1B

Expression for MTNR1B Gene

mRNA expression in normal human tissues for MTNR1B Gene

mRNA differential expression in normal tissues according to GTEx for MTNR1B Gene

This gene is overexpressed in Testis (15.9), Brain - Nucleus accumbens (basal ganglia) (12.2), and Brain - Hypothalamus (4.5).

SOURCE GeneReport for Unigene cluster for MTNR1B Gene Hs.569039

mRNA Expression by UniProt/SwissProt for MTNR1B Gene

P49286-MTR1B_HUMAN
Tissue specificity: Expressed in retina and less in brain and hippocampus
genes like me logo Genes that share expressions with MTNR1B: view

Orthologs for MTNR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for MTNR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTNR1B 36
  • 98.53 (n)
  • 98.34 (a)
MTNR1B 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTNR1B 36
  • 83.06 (n)
  • 76.24 (a)
dog
(Canis familiaris)
Mammalia MTNR1B 36
  • 85.52 (n)
  • 80.97 (a)
MTNR1B 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtnr1b 36
  • 81.2 (n)
  • 80.91 (a)
Mtnr1b 16
Mtnr1b 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTNR1B 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTNR1B 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtnr1b 36
  • 80.15 (n)
  • 80.34 (a)
chicken
(Gallus gallus)
Aves MEL1B 37
  • 68 (a)
OneToOne
MTNR1B 36
  • 67.6 (n)
  • 69.36 (a)
lizard
(Anolis carolinensis)
Reptilia MTNR1B 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493509 36
  • 68.24 (n)
  • 70.55 (a)
zebrafish
(Danio rerio)
Actinopterygii mel1c 36
mtnr1ba 37
  • 57 (a)
OneToMany
mtnr1bb 36
  • 70.4 (n)
  • 69.16 (a)
mtnr1bb 37
  • 65 (a)
OneToMany
mtnr1bb 37
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30340 37
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-35 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
ManyToMany
CSA.5131 37
  • 20 (a)
ManyToMany
Species with no ortholog for MTNR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTNR1B Gene

ENSEMBL:
Gene Tree for MTNR1B (if available)
TreeFam:
Gene Tree for MTNR1B (if available)

Paralogs for MTNR1B Gene

Paralogs for MTNR1B Gene

Selected SIMAP similar genes for MTNR1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MTNR1B: view

Variants for MTNR1B Gene

Sequence variations from dbSNP and Humsavar for MTNR1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1374646 -- 92,972,662(+) TGGCA(C/T)CTCAC intron-variant
rs1562443 -- 92,982,445(+) GGGAA(C/G)TTCAT utr-variant-3-prime
rs1562444 -- 92,982,683(+) CCAGC(A/G)TGGCA utr-variant-3-prime
rs3781637 -- 92,980,604(-) GGTCA(A/G)CCAGA intron-variant
rs3781638 -- 92,980,341(-) GAATA(A/C)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTNR1B Gene

Variant ID Type Subtype PubMed ID
nsv898173 CNV Loss 21882294
esv28204 CNV Gain 19812545
nsv442239 CNV CNV 18776908
esv2744911 CNV Deletion 23290073

Relevant External Links for MTNR1B Gene

HapMap Linkage Disequilibrium report
MTNR1B
Human Gene Mutation Database (HGMD)
MTNR1B

Disorders for MTNR1B Gene

(1) OMIM Diseases for MTNR1B Gene (600804)

(1) University of Copenhagen DISEASES for MTNR1B Gene

(1) Novoseek inferred disease relationships for MTNR1B Gene

Disease -log(P) Hits PubMed IDs
scoliosis idiopathic 65.8 2

Relevant External Links for MTNR1B

Genetic Association Database (GAD)
MTNR1B
Human Genome Epidemiology (HuGE) Navigator
MTNR1B
genes like me logo Genes that share disorders with MTNR1B: view

No data available for UniProtKB/Swiss-Prot for MTNR1B Gene

Publications for MTNR1B Gene

  1. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. (PMID: 7568007) Reppert S.M. … Gusella J.F. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  2. Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. (PMID: 16098099) Ha E. … Hong S.J. (J. Pineal Res. 2005) 3 23 49
  3. The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. (PMID: 17108395) Qiu X.S. … Cheng J.C. (Stud Health Technol Inform 2006) 3 23 49
  4. Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. (PMID: 17632395) Qiu X.S. … Cheng J.C. (Spine 2007) 3 23 49
  5. Variants in MTNR1B influence fasting glucose levels. (PMID: 19060907) Prokopenko I. … Abecasis G.R. (Nat. Genet. 2009) 3 23 49

Products for MTNR1B Gene

Sources for MTNR1B Gene

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