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Aliases for MTNR1A Gene

Aliases for MTNR1A Gene

  • Melatonin Receptor 1A 2 3
  • Mel1a Receptor 3 4
  • MEL-1A-R 3 4
  • Melatonin Receptor Type 1A 3
  • MT1 3

External Ids for MTNR1A Gene

Summaries for MTNR1A Gene

Entrez Gene Summary for MTNR1A Gene

  • This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTNR1A Gene

MTNR1A (Melatonin Receptor 1A) is a Protein Coding gene. Diseases associated with MTNR1A include idiopathic scoliosis and sleep disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone binding and organic cyclic compound binding. An important paralog of this gene is MTNR1B.

UniProtKB/Swiss-Prot for MTNR1A Gene

  • High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity

Tocris Summary for MTNR1A Gene

  • Melatonin receptors are a group of high affinity Gi/Go protein-coupled receptors, which are split into two subtypes; MT1 and MT2. A third melatonin receptor, MT3, was proposed to exist but it has since been shown to be the hamster homolog of human quinone reductase 2 and is therefore not considered within this GPCR classification. MT1 and MT2 receptors are widely distributed with high concentrations found in the brain (especially in the suprachiasmatic nucleus) and in the retina. Lower expression levels are seen in the kidney, heart, lung and liver. Melatonin receptors regulate a variety of physiological and neuroendrocrine functions including control of the endogenous circadian rhythm, thermoregulation and prolactin expression. The human genes encoding MT1 and MT2 receptors are located on chromosome 4q35.1 and chromosome 11q21-22 respectively.

Gene Wiki entry for MTNR1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTNR1A Gene

Genomics for MTNR1A Gene

Genomic Location for MTNR1A Gene

Start:
186,533,655 bp from pter
End:
186,555,567 bp from pter
Size:
21,913 bases
Orientation:
Minus strand

Genomic View for MTNR1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTNR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTNR1A Gene

Regulatory Elements for MTNR1A Gene

Proteins for MTNR1A Gene

  • Protein details for MTNR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48039-MTR1A_HUMAN
    Recommended name:
    Melatonin receptor type 1A
    Protein Accession:
    P48039
    Secondary Accessions:
    • A0AVC5
    • B0M0L2

    Protein attributes for MTNR1A Gene

    Size:
    350 amino acids
    Molecular mass:
    39375 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTNR1A Gene

Proteomics data for MTNR1A Gene at MOPED

Post-translational modifications for MTNR1A Gene

Other Protein References for MTNR1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MTNR1A Gene

Domains for MTNR1A Gene

Gene Families for MTNR1A Gene

HGNC:
  • MTNR :GPCR / Class A : Melatonin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for MTNR1A Gene

Graphical View of Domain Structure for InterPro Entry

P48039

UniProtKB/Swiss-Prot:

MTR1A_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P48039
genes like me logo Genes that share domains with MTNR1A: view

Function for MTNR1A Gene

Molecular function for MTNR1A Gene

GENATLAS Biochemistry: melatonin receptor 1A,disorders with varients R54W and A157V more prominent in a Japanese population,putatively involved in subjects with Circadian rhythm sleep disorders,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity

Gene Ontology (GO) - Molecular Function for MTNR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding IPI 20859254
GO:0008502 melatonin receptor activity IEA --
GO:0042562 hormone binding IPI 10531408
GO:0097159 organic cyclic compound binding IPI 10531408
genes like me logo Genes that share ontologies with MTNR1A: view

Phenotypes for MTNR1A Gene

MGI mutant phenotypes for MTNR1A:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MTNR1A: view

Animal Models for MTNR1A Gene

MGI Knock Outs for MTNR1A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MTNR1A Gene

Localization for MTNR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTNR1A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTNR1A Gene COMPARTMENTS Subcellular localization image for MTNR1A gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MTNR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10531408
GO:0016021 integral component of membrane --
GO:0043235 receptor complex IDA 10531408
genes like me logo Genes that share ontologies with MTNR1A: view

Pathways for MTNR1A Gene

genes like me logo Genes that share pathways with MTNR1A: view

Pathways by source for MTNR1A Gene

Gene Ontology (GO) - Biological Process for MTNR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 9645677
GO:0007617 mating behavior TAS 7946354
GO:0007623 circadian rhythm TAS 9645677
GO:0030828 positive regulation of cGMP biosynthetic process IDA 10531408
genes like me logo Genes that share ontologies with MTNR1A: view

Compounds for MTNR1A Gene

(5) Tocris Compounds for MTNR1A Gene

Compound Action Cas Number
2-Iodomelatonin High affinity melatonin agonist [93515-00-5]
4-P-PDOT MT2 antagonist [134865-74-0]
Luzindole Competitive melatonin MT1/MT2 antagonist [117946-91-5]
Melatonin Endogenous hormone; agonist at MT1 and MT2 [73-31-4]
Prazosin hydrochloride alpha1 and alpha2B antagonist. MT3 antagonist [19237-84-4]

(3) Drugbank Compounds for MTNR1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Agomelatine
  • S-20098
138112-76-2 target
Melatonin
  • MEL
73-31-4 target agonist
Ramelteon
196597-26-9 target multitarget

(22) IUPHAR Ligand for MTNR1A Gene

Ligand Type Action Affinity Pubmed IDs
2-iodo-melatonin Agonist Full agonist 11
ramelteon Agonist Full agonist 10.9
2-[125I]MLT Agonist Full agonist 10.7
LY 156735 Agonist Full agonist 10.1
[3H]melatonin Agonist Full agonist 9.9
GR 196429 Agonist Full agonist 9.9
S26131 Antagonist Antagonist 9.3
S26284 Agonist Partial agonist 9.2
6-Cl-MLT Agonist Full agonist 9.2
6-hydroxymelatonin Agonist Full agonist 9.2
IIK7 Agonist Full agonist 8.3
S22153 Antagonist Antagonist 8.1
5-HEAT Agonist Full agonist 7.8
S24014 Agonist Partial agonist 7.5
K185 Antagonist Antagonist 7.2
4P-PDOT Antagonist Antagonist 7.2
S24773 Agonist Full agonist 7.1
GR 128107 Agonist Partial agonist 6.9
S20928 Antagonist Antagonist 6.9
luzindole Antagonist Antagonist 6.8
agomelatine Antagonist Antagonist 6.2
melatonin Antagonist Antagonist 5.2

(2) Novoseek inferred chemical compound relationships for MTNR1A Gene

Compound -log(P) Hits PubMed IDs
2[125i]iodomelatonin 88.8 5
melatonin 84.7 32
genes like me logo Genes that share compounds with MTNR1A: view

Transcripts for MTNR1A Gene

mRNA/cDNA for MTNR1A Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTNR1A Gene

Melatonin receptor 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTNR1A Gene

No ASD Table

Relevant External Links for MTNR1A Gene

GeneLoc Exon Structure for
MTNR1A
ECgene alternative splicing isoforms for
MTNR1A

Expression for MTNR1A Gene

mRNA expression in normal human tissues for MTNR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTNR1A Gene

This gene is overexpressed in Kidney - Cortex (14.5), Brain - Cerebellar Hemisphere (9.1), Testis (6.0), Brain - Cerebellum (5.7), and Colon - Transverse (4.4).

SOURCE GeneReport for Unigene cluster for MTNR1A Gene Hs.243467

mRNA Expression by UniProt/SwissProt for MTNR1A Gene

P48039-MTR1A_HUMAN
Tissue specificity: Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus
genes like me logo Genes that share expressions with MTNR1A: view

No data available for Protein expression for MTNR1A Gene

Orthologs for MTNR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for MTNR1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTNR1A 35
  • 99.08 (n)
  • 98.62 (a)
MTNR1A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTNR1A 35
  • 84.53 (n)
  • 83.67 (a)
MTNR1A 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTNR1A 35
  • 85.34 (n)
  • 88.22 (a)
mouse
(Mus musculus)
Mammalia Mtnr1a 35
  • 81.62 (n)
  • 84.86 (a)
Mtnr1a 16
Mtnr1a 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTNR1A 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mtnr1a 35
  • 82.57 (n)
  • 84.86 (a)
chicken
(Gallus gallus)
Aves MEL1A 36
  • 77 (a)
OneToOne
MTNR1A 35
  • 74.48 (n)
  • 80 (a)
lizard
(Anolis carolinensis)
Reptilia MTNR1A 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397808 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mtnr1a 35
  • 71.24 (n)
  • 77.43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11655 35
zebrafish
(Danio rerio)
Actinopterygii LOC565718 35
  • 70.86 (n)
  • 77.43 (a)
mel1ar 35
MTNR1A (2 of 2) 36
  • 75 (a)
OneToMany
mtnr1aa 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30340 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-35 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
CSA.5131 36
  • 19 (a)
ManyToMany
Species with no ortholog for MTNR1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTNR1A Gene

ENSEMBL:
Gene Tree for MTNR1A (if available)
TreeFam:
Gene Tree for MTNR1A (if available)

Paralogs for MTNR1A Gene

Paralogs for MTNR1A Gene

Selected SIMAP similar genes for MTNR1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTNR1A: view

Variants for MTNR1A Gene

Sequence variations from dbSNP and Humsavar for MTNR1A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1800884 - 186,534,272(-) GCTGG(C/T)GGCCG reference, missense
rs1800885 - 186,555,206(-) TGTAT(C/T)GGAAC reference, missense
rs1899434 -- 186,541,052(-) AACGC(A/G)GGCTG intron-variant
rs2119882 -- 186,555,751(+) TGGGA(C/T)CAAAT upstream-variant-2KB
rs2119883 -- 186,547,921(-) TCTCA(A/G)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTNR1A Gene

Variant ID Type Subtype PubMed ID
nsv525719 CNV Gain 19592680
nsv4646 CNV Insertion 18451855
esv2728948 CNV Deletion 23290073
esv1667505 CNV Insertion 17803354
nsv289366 CNV Insertion 16902084
esv2728949 CNV Deletion 23290073
esv1214111 CNV Deletion 17803354

Relevant External Links for MTNR1A Gene

HapMap Linkage Disequilibrium report
MTNR1A
Human Gene Mutation Database (HGMD)
MTNR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTNR1A Gene

Disorders for MTNR1A Gene

(1) Novoseek inferred disease relationships for MTNR1A Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 21.7 2

Relevant External Links for MTNR1A

Genetic Association Database (GAD)
MTNR1A
Human Genome Epidemiology (HuGE) Navigator
MTNR1A
genes like me logo Genes that share disorders with MTNR1A: view

No data available for UniProtKB/Swiss-Prot for MTNR1A Gene

Publications for MTNR1A Gene

  1. Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). (PMID: 7558006) Slaugenhaupt S.A. … Reppert S.M. (Genomics 1995) 2 3 23
  2. Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders. (PMID: 10471411) Ebisawa T. … Yamauchi T. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis. (PMID: 12973153) Morcuende J.A. … Sheffield V. (Spine 2003) 3 23 48
  4. Lack of association between the promoter polymorphism of the MTNR1A gene and adolescent idiopathic scoliosis. (PMID: 18794763) Qiu X.S. … Qiu Y. (Spine 2008) 3 23 48
  5. Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo. (PMID: 17349020) Satomura K. … Nagayama M. (J. Pineal Res. 2007) 3 23

Products for MTNR1A Gene

Sources for MTNR1A Gene

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