Aliases for MTNR1A Gene
External Ids for MTNR1A Gene
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTNR1A Gene
MTNR1A (Melatonin Receptor 1A) is a Protein Coding gene. Diseases associated with MTNR1A include idiopathic scoliosis and sleep disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone binding and organic cyclic compound binding. An important paralog of this gene is MTNR1B.
UniProtKB/Swiss-Prot for MTNR1A Gene
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity
Melatonin receptors are a group of high affinity Gi/Go protein-coupled receptors, which are split into two subtypes; MT1 and MT2. A third melatonin receptor, MT3, was proposed to exist but it has since been shown to be the hamster homolog of human quinone reductase 2 and is therefore not considered within this GPCR classification. MT1 and MT2 receptors are widely distributed with high concentrations found in the brain (especially in the suprachiasmatic nucleus) and in the retina. Lower expression levels are seen in the kidney, heart, lung and liver. Melatonin receptors regulate a variety of physiological and neuroendrocrine functions including control of the endogenous circadian rhythm, thermoregulation and prolactin expression. The human genes encoding MT1 and MT2 receptors are located on chromosome 4q35.1 and chromosome 11q21-22 respectively.