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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTNR1A Gene

protein-coding   GIFtS: 64
GCID: GC04M187454

Melatonin Receptor 1A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melatonin Receptor 1A1 2
Mel1a Receptor2 3
MEL-1A-R2
MT12
Melatonin Receptor Type 1A2
Mel-1A-R3

External Ids:    HGNC: 74631   Entrez Gene: 45432   Ensembl: ENSG000001684127   OMIM: 6006655   UniProtKB: P480393   

Export aliases for MTNR1A gene to outside databases

Previous GC identifers: GC04M188488 GC04M188133 GC04M188149 GC04M187829 GC04M187691 GC04M187347 GC04M183202


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTNR1A Gene:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the
pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin
effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an
integral membrane protein that is readily detectable and localized to two specific regions of the brain. The
hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars
tuberalis may be responsible for the reproductive effects of melatonin. (provided by RefSeq, Jul 2008)

GeneCards Summary for MTNR1A Gene: 
MTNR1A (melatonin receptor 1A) is a protein-coding gene. Diseases associated with MTNR1A include sleep disorder, and tardive dyskinesia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include organic cyclic compound binding and hormone binding. An important paralog of this gene is MTNR1B.

UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039
Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of
melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit
adenylate cyclase activity

summary for MTNR1A Gene:
Melatonin receptors are a group of high affinity Gi/Go protein-coupled receptors, which are split into two
subtypes; MT1 and MT2. A third melatonin receptor, MT3, was proposed to exist but it has since been shown to
be the hamster homolog of human quinone reductase 2 and is therefore not considered within this GPCR
classification. MT1 and MT2 receptors are widely distributed with high concentrations found in the brain
(especially in the suprachiasmatic nucleus) and in the retina. Lower expression levels are seen in the
kidney, heart, lung and liver. Melatonin receptors regulate a variety of physiological and neuroendrocrine
functions including control of the endogenous circadian rhythm, thermoregulation and prolactin expression.
The human genes encoding MT1 and MT2 receptors are located on chromosome 4q35.1 and chromosome 11q21-22
respectively.

Gene Wiki entry for MTNR1A (Melatonin receptor 1A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTNR1A gene promoter:
         STAT5B   C/EBPbeta   HTF   STAT5A   C/EBPalpha   E47   RORalpha2   GATA-1   TGIF   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTNR1A promoter sequence
   Search SABiosciences Chromatin IP Primers for MTNR1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTNR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35

MTNR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTNR1A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M187454:  view genomic region     (about GC identifiers)

Start:
187,454,809 bp from pter      End:
187,476,721 bp from pter
Size:
21,913 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039 (See protein sequence)
Recommended Name: Melatonin receptor type 1A  
Size: 350 amino acids; 39375 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A0AVC5 B0M0L2

Explore the universe of human proteins at neXtProt for MTNR1A: NX_P48039

Explore proteomics data for MTNR1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48039

  • MTNR1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTNR1A Protein Expression
    REFSEQ proteins: NP_005949.1  
    ENSEMBL proteins: 
     ENSP00000302811  
    Reactome Protein details: P48039
    Human Recombinant Protein Products for MTNR1A: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA10531408
    GO:0016021integral to membrane ----
    GO:0043235receptor complex IDA10531408

    MTNR1A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MTNR: GPCR / Class A : Melatonin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: MT1 receptor 
    Melatonin receptors

    4 InterPro protein domains:
     IPR002278 Mel_1A_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000025 Melatonin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P48039

    ProtoNet protein and cluster: P48039

    2 Blocks protein domains:
    IPB000025 Melatonin receptor signature
    IPB002278 Melatonin 1A receptor signature


    UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039
    Similarity: Belongs to the G-protein coupled receptor 1 family


    MTNR1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTR1A_HUMAN, P48039
    Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of
    melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit
    adenylate cyclase activity

         Genatlas biochemistry entry for MTNR1A:
    melatonin receptor 1A,disorders with varients R54W and A157V more prominent in a Japanese population,putatively
    involved in subjects with Circadian rhythm sleep disorders,G protein coupled receptor superfamily

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI--
    GO:0008502melatonin receptor activity IEA--
    GO:0042562hormone binding IPI10531408
    GO:0097159organic cyclic compound binding IPI10531408
         
    MTNR1A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mtnr1a):
     behavior/neurological 

    MTNR1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mtnr1atm1Rep for MTNR1A

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MTNR1A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Sweet Taste Signaling
    Melatonin Signaling0.72
    4Prostanoid ligand receptors
    Small Ligand GPCRs0.40
    5Circadian entrainment
    Circadian entrainment0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MTNR1A
        Melatonin Signaling

    2 BioSystems Pathways for MTNR1A
        GPCRs, Class A Rhodopsin-like
    Small Ligand GPCRs

    5/6        Reactome Pathways for MTNR1A (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for MTNR1A):
        Neuroactive ligand-receptor interaction
    Circadian entrainment


    MTNR1A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTNR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/170 Interacting proteins for MTNR1A (P480392, 3 ENSP000003028114) via UniProtKB, MINT, STRING, and/or I2D (see all 170)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RGS20O760812, 3, ENSP000002973134MINT-8087198 MINT-8087089 MINT-8087146 MINT-8087131 MINT-8087181 MINT-8087038 MINT-8087164 I2D: score=1 STRING: ENSP00000297313
    MTNR1BP492862, 3, ENSP000002570684MINT-8087089 MINT-8087107 I2D: score=3 STRING: ENSP00000257068
    CALRP277973, ENSP000003208664I2D: score=2 STRING: ENSP00000320866
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    GNB4Q9HAV03, ENSP000002325644I2D: score=2 STRING: ENSP00000232564
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS9645677
    GO:0007617mating behavior TAS7946354
    GO:0007623circadian rhythm TAS9645677
    GO:0030828positive regulation of cGMP biosynthetic process IDA10531408

    MTNR1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MTNR1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MTNR1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    4-P-PDOTMT2 antagonist[134865-74-0]
    LuzindoleCompetitive melatonin MT1/MT2 antagonist[117946-91-5]
    MelatoninEndogenous hormone; agonist at MT1 and MT2[73-31-4]
    2-IodomelatoninHigh affinity melatonin agonist[93515-00-5]
    Prazosin hydrochloridealpha1 and alpha2B antagonist. MT3 antagonist[19237-84-4]

    3 DrugBank Compounds for MTNR1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ramelteon-- 196597-26-9targetmultitarget19568703 19228178 17015817 16730121 16432265 17389558 15695169 11752352 17803013 19768947 15869323 16173650 17157111
    MelatoninMEL (see all 4)73-31-4targetagonist15992934 19463840 20674373 11752352 19449447 20827520 19966183
    AgomelatineS-20098 (see all 2)138112-76-2target--15289999

    10/22 IUPHAR Ligands for MTNR1A (MT1 receptor) (see all 22)    About this table 
    LigandTypeActionAffinityPubmed IDs
    2-iodo-melatonin
    AgonistFull agonist10.2 - 1112764576 9089668
    ramelteon
    AgonistFull agonist10.915695169
    2-[125I]MLT
    AgonistFull agonist9.9 - 10.712764576 9089668
    agomelatine
    AgonistFull agonist10 - 10.412764576 9618428
    LY 156735
    AgonistFull agonist10.115302228
    [3H]melatonin
    AgonistFull agonist9.4 - 9.910696085
    GR 196429
    AgonistFull agonist9.4 - 9.910696085 9618428
    melatonin
    AgonistFull agonist9.1 - 9.712764576 9089668
    S26131
    AntagonistAntagonist8.4 - 9.312764576
    S26284
    AgonistPartial agonist8.5 - 9.212764576

    2 Novoseek inferred chemical compound relationships for MTNR1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2[125i]iodomelatonin 88.8 5 9247069 (2), 9089668 (2), 7568007 (1)
    melatonin 84.7 47 9141494 (3), 11841602 (2), 12973153 (2), 11408347 (2) (see all 25)

    Search CenterWatch for drugs/clinical trials and news about MTNR1A / MTR1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for MTNR1A gene: 
    NM_005958.3  

    Unigene Cluster for MTNR1A:

    Melatonin receptor 1A
    Hs.243467  [show with all ESTs]
    Unigene Representative Sequence: BC126297
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307161(uc003izd.1)

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    Additional mRNA sequence: 

    AF435588.1 BC074946.2 BC074947.2 BC113816.1 BC126297.1 BC126299.1 EU432127.1 U14108.1 

    1 DOTS entry:

    DT.91748277 

    23 AceView cDNA sequences:

    AL703888 BC074946 BC074947 AI204202 BX112166 AI001834 BC034307 AI138290 
    AI126472 AF435588 BU567547 CB155561 U14108 BC038717 CB122088 BI520221 
    NM_005958 BU194998 AI208101 AI221202 BI520849 BI459826 BG719069 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTNR1A expression in normal human tissues (normalized intensities)      MTNR1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTATTTCA
    MTNR1A Expression
    About this image


    MTNR1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer

    See MTNR1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTNR1A

    SOURCE GeneReport for Unigene cluster: Hs.243467

    UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039
    Tissue specificity: Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN).
    Hippocampus

        SABiosciences Expression via Pathway-Focused PCR Arrays including MTNR1A: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MTNR1A gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtnr1a1 , 5 melatonin receptor 1A1, 5 81.62(n)1
    84.86(a)1
      8 (24.95 cM)5
    177731  NM_008639.21  NP_032665.11 
     450691375 
    chicken
    (Gallus gallus)
    Aves MTNR1A1 melatonin receptor 1A 74.59(n)
    80.87(a)
      396319  NM_205362.1  NP_990693.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTNR1A6
    --
    Uncharacterized protein
    82(a)
    69(a)
    1 ↔ 1
    possible ortholog
    5(111605694-111606563)
    2(137854834-137866999)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978082 Mel-1c receptor subtype 73.72(n)    U67881.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mel1ar2 melatonin receptor type 1A z1.7 76.87(n)   30667  AY166824.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta moody1 CG4322-PA 43.43(n)
    29.64(a)
      31168  NM_001201605.1  NP_001188534.1 


    ENSEMBL Gene Tree for MTNR1A (if available)
    TreeFam Gene Tree for MTNR1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTNR1A gene
    MTNR1B2  GPR502  
    3 SIMAP similar genes for MTNR1A using alignment to 4 protein entries:     MTR1A_HUMAN (see all proteins):
    MTNR1B    GPR50    CHRM2

    MTNR1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/667 SNPs in MTNR1A are shown (see all 667)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs591701351,2
    C--183207660(+) AAAAA-/AAAA  
      
    /AAAAA
    GGCCA
    1 -- int11NA 2
    rs1836999751,2
    --187454314(+) TAACTC/TTGCCA 1 -- ds50010--------
    rs1150850731,2
    C,F--187454539(+) TACCCC/ATTTTG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs21656681,2
    C,F,A,H--187454701(+) TATAAC/TGCTGA 1 -- ds500114Minor allele frequency- T:0.08NS NA WA CSA EA 624
    rs1886206301,2
    --187454705(+) ATGCTG/TACAGC 1 -- ds50010--------
    rs2012700751,2
    C--187454796(+) AAGAGC/TGAGGC 1 -- ds50010--------
    rs1128575121,2
    C--187454812(+) GCAGCG/ATGTCC 1 -- ut312Minor allele frequency- A:0.02CSA WA 120
    rs3759821641,2
    C--187454854(+) GGAGTC/TACCTT 2 N D mis10--------
    rs2001926311,2
    C--187454863(+) CTTTAC/TTACAT 2 I V mis11Minor allele frequency- T:0.00EU 1323
    rs1923707641,2
    C--187454891(+) GGAGAC/TGGTTT 2 P syn10--------

    HapMap Linkage Disequilibrium report for MTNR1A (187454809 - 187476721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MTNR1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728949CNV Deletion23290073
    esv2728948CNV Deletion23290073
    esv1214111CNV Deletion17803354
    esv1667505CNV Insertion17803354
    nsv4646CNV Insertion18451855
    nsv289366CNV Insertion16902084
    nsv525719CNV Gain19592680


    Human Gene Mutation Database (HGMD): MTNR1A
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MTNR1A
    DNA2.0 Custom Variant and Variant Library Synthesis for MTNR1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600665    OMIM disorders: --

    20/22 diseases for MTNR1A (see all 22):    About MalaCards
    sleep disorder    tardive dyskinesia    scoliosis    autism spectrum disorder
    pertussis    nephrolithiasis    oral squamous cell carcinoma    attention deficit hyperactivity disorder
    alzheimer's disease    polycystic ovary syndrome    acute myocardial infarction    schizophrenia
    squamous cell carcinoma    obesity    myocardial infarction    rheumatoid arthritis
    arthritis    adenocarcinoma    breast cancer    colorectal cancer


    MTNR1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for MTNR1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 21.7 2 11841602 (1), 17316165 (1)

    Genetic Association Database (GAD): MTNR1A
    Human Genome Epidemiology (HuGE) Navigator: MTNR1A (13 documents)

    Export disorders for MTNR1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTNR1A gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with MTNR1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). (PubMed id 7558006)1, 3, 9 Slaugenhaupt S.A....Reppert S.M. (1995)
    2. Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis. (PubMed id 12973153)1, 4, 9 Morcuende J.A....Sheffield V. (2003)
    3. Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders. (PubMed id 10471411)1, 2, 9 Ebisawa T.... Yamauchi T. (1999)
    4. Lack of association between the promoter polymorphism of the MTNR1A gene and adolescent idiopathic scoliosis. (PubMed id 18794763)1, 4, 9 Qiu X.S....Qiu Y. (2008)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Examination of association of genes in the serotonin system to autism. (PubMed id 19184136)1, 4 Anderson B.M....Haines J.L. (2009)
    7. [Effect of genetic polymorphism of MTNR1A gene on adolescent idiopathic scoliosis] (PubMed id 18067741)1, 4 Qiu X.S....Cheng C.Y. (2007)
    8. Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. (PubMed id 16098099)1, 4 Ha E....Hong S.J. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. (PubMed id 7946354)1, 2 Reppert S.M.... Ebisawa T. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4543 HGNC: 7463 AceView: MTNR1A Ensembl:ENSG00000168412 euGenes: HUgn4543
    ECgene: MTNR1A Kegg: 4543 H-InvDB: MTNR1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTNR1A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Melatonin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTNR1A gene:
    Search GeneIP for patents involving MTNR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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