Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTNR1A Gene

Aliases for MTNR1A Gene

  • Melatonin Receptor 1A 2 3 5
  • Mel1a Receptor 3 4
  • MEL-1A-R 3 4
  • Melatonin Receptor Type 1A 3
  • MT1 3

External Ids for MTNR1A Gene

Previous GeneCards Identifiers for MTNR1A Gene

  • GC04M188488
  • GC04M188133
  • GC04M188149
  • GC04M187829
  • GC04M187691
  • GC04M187454
  • GC04M187347
  • GC04M183202

Summaries for MTNR1A Gene

Entrez Gene Summary for MTNR1A Gene

  • This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTNR1A Gene

MTNR1A (Melatonin Receptor 1A) is a Protein Coding gene. Diseases associated with MTNR1A include Idiopathic Scoliosis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1B.

UniProtKB/Swiss-Prot for MTNR1A Gene

  • High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Tocris Summary for MTNR1A Gene

  • Melatonin receptors are a group of high affinity Gi/G0 protein-coupled receptors, which are split into two subtypes; MT1 and MT2. They are widely distributed with high concentrations found in the brain (especially in the suprachiasmatic nucleus) and in the retina.

Gene Wiki entry for MTNR1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTNR1A Gene

Genomics for MTNR1A Gene

Regulatory Elements for MTNR1A Gene

Enhancers for MTNR1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F186570 1 FANTOM5 Ensembl ENCODE 0.4 -14.8 -14834 0.8 SCRT2 GC04P186578 MTNR1A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MTNR1A on UCSC Golden Path with GeneCards custom track

Promoters for MTNR1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001866327 367 1201 CTCF ZNF76 ZFHX2 FOXK2 SCRT2 PRDM10 ZNF600 RNF2 L3MBTL2 NFIA

Genomic Location for MTNR1A Gene

Chromosome:
4
Start:
186,533,000 bp from pter
End:
186,555,567 bp from pter
Size:
22,568 bases
Orientation:
Minus strand

Genomic View for MTNR1A Gene

Genes around MTNR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTNR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTNR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTNR1A Gene

Proteins for MTNR1A Gene

  • Protein details for MTNR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48039-MTR1A_HUMAN
    Recommended name:
    Melatonin receptor type 1A
    Protein Accession:
    P48039
    Secondary Accessions:
    • A0AVC5
    • B0M0L2

    Protein attributes for MTNR1A Gene

    Size:
    350 amino acids
    Molecular mass:
    39375 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTNR1A Gene

Post-translational modifications for MTNR1A Gene

  • Glycosylation at Asn 4 and Asn 10

Other Protein References for MTNR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTNR1A Gene

Domains & Families for MTNR1A Gene

Gene Families for MTNR1A Gene

Suggested Antigen Peptide Sequences for MTNR1A Gene

Graphical View of Domain Structure for InterPro Entry

P48039

UniProtKB/Swiss-Prot:

MTR1A_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MTNR1A: view

Function for MTNR1A Gene

Molecular function for MTNR1A Gene

GENATLAS Biochemistry:
melatonin receptor 1A,disorders with varients R54W and A157V more prominent in a Japanese population,putatively involved in subjects with Circadian rhythm sleep disorders,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for MTNR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 20859254
GO:0008502 melatonin receptor activity IEA,TAS --
GO:0042562 hormone binding IPI 10531408
GO:0097159 organic cyclic compound binding IPI 10531408
genes like me logo Genes that share ontologies with MTNR1A: view
genes like me logo Genes that share phenotypes with MTNR1A: view

Animal Models for MTNR1A Gene

MGI Knock Outs for MTNR1A:

Animal Model Products

  • Taconic Biosciences Mouse Models for MTNR1A

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for MTNR1A (Melatonin R1A/MT1/MTNR1A)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MTNR1A Gene

Localization for MTNR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTNR1A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTNR1A Gene COMPARTMENTS Subcellular localization image for MTNR1A gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MTNR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA,TAS 10531408
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 10531408
genes like me logo Genes that share ontologies with MTNR1A: view

Pathways & Interactions for MTNR1A Gene

genes like me logo Genes that share pathways with MTNR1A: view

Pathways by source for MTNR1A Gene

Gene Ontology (GO) - Biological Process for MTNR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 9645677
GO:0007617 mating behavior TAS 7946354
genes like me logo Genes that share ontologies with MTNR1A: view

No data available for SIGNOR curated interactions for MTNR1A Gene

Drugs & Compounds for MTNR1A Gene

(42) Drugs for MTNR1A Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Melatonin Approved, Vet_approved Nutra Antagonist, binder, Target, agonist Melatonin receptors MT inhibitor 255
Ramelteon Approved, Investigational Pharma Full agonist, Agonist, agonist, Target, multitarget Agonist of melatonin receptor(M1-M2),highly selective 0
Agomelatine Approved, Investigational Pharma Antagonist, agonist, Target MT1/MT2 / 5-HT2C agonist 0
Tasimelteon Approved Pharma Target, agonist 0
VEC-162 Investigational Pharma Target 0

(2) Additional Compounds for MTNR1A Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prazosin hydrochloride
19237-84-4

(5) Tocris Compounds for MTNR1A Gene

Compound Action Cas Number
2-Phenylmelatonin Potent melatonin agonist 151889-03-1
4-P-PDOT MT2 antagonist 620170-78-7
GR 135531 High affinity melatonin MT3 ligand 190277-13-5
Luzindole Competitive melatonin MT1/MT2 antagonist 117946-91-5
Prazosin hydrochloride alpha1 and alpha2B antagonist. MT3 antagonist 19237-84-4

(11) ApexBio Compounds for MTNR1A Gene

Compound Action Cas Number
2-Iodomelatonin 93515-00-5
2-Phenylmelatonin 151889-03-1
4-P-PDOT 134865-74-0
6-Chloromelatonin 63762-74-3
8-M-PDOT 134865-70-6
DH 97 220339-00-4
GR 135531 190277-13-5
Luzindole 117946-91-5
Melatonin Melatonin receptors MT inhibitor 73-31-4
N-Acetyltryptamine 1016-47-3
Ramelteon Agonist of melatonin receptor(M1-M2),highly selective 196597-26-9
genes like me logo Genes that share compounds with MTNR1A: view

Transcripts for MTNR1A Gene

mRNA/cDNA for MTNR1A Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTNR1A Gene

Melatonin receptor 1A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for MTNR1A (Melatonin R1A/MT1/MTNR1A)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTNR1A Gene

No ASD Table

Relevant External Links for MTNR1A Gene

GeneLoc Exon Structure for
MTNR1A
ECgene alternative splicing isoforms for
MTNR1A

Expression for MTNR1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTNR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTNR1A Gene

This gene is overexpressed in Kidney - Cortex (x14.5), Brain - Cerebellar Hemisphere (x9.1), Testis (x6.0), Brain - Cerebellum (x5.7), and Colon - Transverse (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MTNR1A Gene:

MTNR1A

SOURCE GeneReport for Unigene cluster for MTNR1A Gene:

Hs.243467

mRNA Expression by UniProt/SwissProt for MTNR1A Gene:

P48039-MTR1A_HUMAN
Tissue specificity: Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
genes like me logo Genes that share expression patterns with MTNR1A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MTNR1A Gene

Orthologs for MTNR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for MTNR1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTNR1A 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia MTNR1A 34
  • 85.34 (n)
cow
(Bos Taurus)
Mammalia MTNR1A 34 35
  • 84.53 (n)
rat
(Rattus norvegicus)
Mammalia Mtnr1a 34
  • 82.57 (n)
mouse
(Mus musculus)
Mammalia Mtnr1a 34 16 35
  • 81.62 (n)
oppossum
(Monodelphis domestica)
Mammalia MTNR1A 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MEL1A 35
  • 77 (a)
OneToOne
MTNR1A 34
  • 74.48 (n)
lizard
(Anolis carolinensis)
Reptilia MTNR1A 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtnr1a 34
  • 71.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397808 34
zebrafish
(Danio rerio)
Actinopterygii MTNR1A (2 of 2) 35
  • 75 (a)
OneToMany
mtnr1aa 35
  • 75 (a)
OneToMany
LOC565718 34
  • 70.86 (n)
mel1ar 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11655 34
fruit fly
(Drosophila melanogaster)
Insecta CG30340 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-35 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
ManyToMany
CSA.5131 35
  • 19 (a)
ManyToMany
Species where no ortholog for MTNR1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTNR1A Gene

ENSEMBL:
Gene Tree for MTNR1A (if available)
TreeFam:
Gene Tree for MTNR1A (if available)

Paralogs for MTNR1A Gene

Paralogs for MTNR1A Gene

(3) SIMAP similar genes for MTNR1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTNR1A: view

Variants for MTNR1A Gene

Sequence variations from dbSNP and Humsavar for MTNR1A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10434256 -- 186,549,222(+) CAAGA(A/T)CATAT intron-variant
rs10434308 -- 186,548,848(+) ATATA(C/T)ACTAT intron-variant
rs10691765 -- 186,540,813(+) AAGGA(-/AGGA)CCAGG intron-variant
rs10866293 -- 186,551,377(+) TCTGG(C/T)TGATT intron-variant
rs111289735 -- 186,547,525(+) TACTC(A/G)CGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTNR1A Gene

Variant ID Type Subtype PubMed ID
dgv5494n100 CNV gain 25217958
dgv5495n100 CNV gain 25217958
esv1214111 CNV deletion 17803354
esv1667505 CNV insertion 17803354
esv2728948 CNV deletion 23290073
esv2728949 CNV deletion 23290073
nsv1015619 CNV gain 25217958
nsv1022361 CNV gain 25217958
nsv1025244 CNV gain 25217958
nsv1073826 CNV deletion 25765185
nsv1131853 CNV deletion 24896259
nsv1142415 CNV tandem duplication 24896259
nsv289366 CNV insertion 16902084
nsv4646 CNV insertion 18451855
nsv525719 CNV gain 19592680
nsv596417 CNV gain 21841781

Variation tolerance for MTNR1A Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTNR1A Gene

Human Gene Mutation Database (HGMD)
MTNR1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTNR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTNR1A Gene

Disorders for MTNR1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MTNR1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
idiopathic scoliosis
  • scoliosis idiopathic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MTNR1A

Genetic Association Database (GAD)
MTNR1A
Human Genome Epidemiology (HuGE) Navigator
MTNR1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTNR1A
genes like me logo Genes that share disorders with MTNR1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTNR1A Gene

Publications for MTNR1A Gene

  1. Lack of association between the promoter polymorphism of the MTNR1A gene and adolescent idiopathic scoliosis. (PMID: 18794763) Qiu X.S. … Qiu Y. (Spine 2008) 3 22 46 64
  2. Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis. (PMID: 12973153) Morcuende J.A. … Sheffield V. (Spine 2003) 3 22 46 64
  3. Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders. (PMID: 10471411) Ebisawa T. … Yamauchi T. (Biochem. Biophys. Res. Commun. 1999) 3 4 22 64
  4. Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). (PMID: 7558006) Slaugenhaupt S.A. … Reppert S.M. (Genomics 1995) 2 3 22 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for MTNR1A Gene

Sources for MTNR1A Gene

Content
Loading form....