Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MTNR1A Gene

protein-coding GIFtS: 62
GCID: GC04M187347

melatonin receptor 1A

Explore 17 diseases affiliated with
MTNR1A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Melatonin Receptor 1A¹ ²
MEL-1A-R¹ ²
Mel1a Receptor² ³
MT1²
Melatonin Receptor Type 1A²
Mel-1A-R³

External Ids:	HGNC: 7463¹	Entrez Gene: 4543²	Ensembl: ENSG00000168412⁷	OMIM: 600665⁵	UniProtKB: P48039³

Export aliases for MTNR1A gene to outside databases

Previous GC identifers: GC04M188488 GC04M188133 GC04M188149 GC04M187829 GC04M187691 GC04M187454 GC04M183202

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTNR1A:

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the

pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects

on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral

membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic

suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be

responsible for the reproductive effects of melatonin. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039

Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin.

The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase

activity

summary for MTNR1A:

Melatonin receptors are a group of high affinity Gi/Go protein-coupled receptors, which are split into two

subtypes; MT1 and MT2. A third melatonin receptor, MT3, was proposed to exist but it has since been shown to

be the hamster homolog of human quinone reductase 2 and is therefore not considered within this GPCR

classification. MT1 and MT2 receptors are widely distributed with high concentrations found in the brain

(especially in the suprachiasmatic nucleus) and in the retina. Lower expression levels are seen in the

kidney, heart, lung and liver. Melatonin receptors regulate a variety of physiological and neuroendrocrine

functions including control of the endogenous circadian rhythm, thermoregulation and prolactin expression.

The human genes encoding MT1 and MT2 receptors are located on chromosome 4q35.1 and chromosome 11q21-22

respectively.

Gene Wiki entry for MTNR1A (Melatonin receptor 1A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MTNR1A gene promoter:
STAT5B C/EBPbeta HTF STAT5A C/EBPalpha E47 RORalpha2 GATA-1 TGIF ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MTNR1A promoter sequence

Search SABiosciences Chromatin IP Primers for MTNR1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTNR1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.2 HGNC cytogenetic band: 4q35

MTNR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTNR1A gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M187347: view genomic region (about GC identifiers)

Start:	187,347,700 bp from pter	End:	187,476,721 bp from pter
Size:	129,022 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039 (See protein sequence)

Recommended Name: Melatonin receptor type 1A

Size: 350 amino acids; 39375 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A0AVC5 B0M0L2

Explore the universe of human proteins at neXtProt for MTNR1A: NX_P48039

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48039

MTNR1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005949.1

ENSEMBL proteins:

ENSP00000422449 ENSP00000302811

Reactome Protein details: P48039
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MTNR1A Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MTNR1A OriGene Protein Over-expression Lysate: MTNR1A OriGene Custom Protein Services for MTNR1A
	GenScript Custom Purified and Recombinant Proteins Services for MTNR1A
	Novus Biologicals MTNR1A Proteins Novus Biologicals MTNR1A Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MTNR1A

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IDA	10531408
GO:0043235	receptor complex	IDA	10531408

MTNR1A for ontologies About GeneDecksing

MTNR1A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): MTNR1A OriGene Custom Antibody Services for MTNR1A
	GenScript Custom Superior Antibodies Services for MTNR1A
	Novus Biologicals MTNR1A Antibodies
	Search for Antibodies for MTNR1A at Abcam
	Uscn Antibodies for MTNR1A
	ThermoFisher Antibodies for MTNR1A

Assay Products for MTNR1A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript MTNR1A-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MTNR1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MTNR1A for domains About GeneDecksing

4 InterPro domains/families:

IPR002278 Mel_1A_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR000025 Melatonin_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P48039

ProtoNet protein and cluster: P48039

2 Blocks protein families:

IPB000025 Melatonin receptor signature

IPB002278 Melatonin 1A receptor signature

UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039

Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin.

The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase

activity

Genatlas biochemistry entry for MTNR1A:

melatonin receptor 1A,disorders with varients R54W and A157V more prominent in a Japanese population,putatively

involved in subjects with Circadian rhythm sleep disorders,G protein coupled receptor superfamily

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTNR1A
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MTNR1A
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTNR1A (see all 7) OriGene shRNA RFP: MTNR1A OriGene siRNA: MTNR1A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTNR1A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MTNR1A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTNR1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTNR1A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MTNR1A (NM_005958)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTNR1A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTNR1A

Cell Line Products:		GenScript MTNR1A-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for MTNR1A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1A

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008502	melatonin receptor activity	IEA	--
GO:0042562	hormone binding	IPI	10531408
GO:0097159	organic cyclic compound binding	IPI	10531408

MTNR1A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Mtnr1a^tm1Rep for MTNR1A
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Mtnr1a):

behavior/neurological

MTNR1A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Sweet Taste Signaling

Melatonin Signaling

0.72

Prostanoid ligand receptors

Small Ligand GPCRs

0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MTNR1A

Melatonin Signaling

2 BioSystems Pathways for MTNR1A

	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs

5/6 Reactome Pathways for MTNR1A (see all 6)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events
	GPCR ligand binding

1 Kegg Pathway (Kegg details for MTNR1A):

Neuroactive ligand-receptor interaction

MTNR1A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MTNR1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/170 Interacting proteins for MTNR1A (P48039^{2, 3} ENSP00000302811⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 170)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RGS20	O76081²^,³, ENSP00000297313⁴	MINT-8087198 MINT-8087089 MINT-8087146 MINT-8087131 MINT-8087181 MINT-8087038 MINT-8087164 I2D: score=1 STRING: ENSP00000297313
MTNR1B	P49286²^,³, ENSP00000257068⁴	MINT-8087089 MINT-8087107 I2D: score=3 STRING: ENSP00000257068
CALR	P27797³, ENSP00000320866⁴	I2D: score=2 STRING: ENSP00000320866
GNB1	P62873³, ENSP00000367872⁴	I2D: score=2 STRING: ENSP00000367872
GNB4	Q9HAV0³, ENSP00000232564⁴	I2D: score=2 STRING: ENSP00000232564

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9645677
GO:0007617	mating behavior	TAS	7946354
GO:0007623	circadian rhythm	TAS	9645677
GO:0030828	positive regulation of cGMP biosynthetic process	IDA	10531408

MTNR1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MTNR1A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MTNR1A available from Tocris Bioscience About this table

Compound	Action	CAS #
6-Chloromelatonin	Melatonin agonist	[63762-74-3]
Luzindole	Competitive melatonin MT1/MT2 antagonist	[117946-91-5]
Melatonin	Endogenous hormone; agonist at MT1 and MT2	[73-31-4]
2-Phenylmelatonin	Potent melatonin agonist	[151889-03-1]
2-Iodomelatonin	High affinity melatonin agonist	[93515-00-5]

3 DrugBank Compounds for MTNR1A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Ramelteon	--	196597-26-9	target	multitarget	19568703 19228178 17015817 16730121 16432265 17389558 15695169 11752352 17803013 19768947 15869323 16173650 17157111
Melatonin	MEL (see all 4)	73-31-4	target	agonist	15992934 19463840 20674373 11752352 19449447 20827520 19966183
Agomelatine	S-20098 (see all 2)	138112-76-2	target	--	15289999

2 Novoseek chemical compound relationships for MTNR1A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2[125i]iodomelatonin	88.8	5	9247069 (2), 9089668 (2), 7568007 (1)
melatonin	84.7	47	9141494 (3), 11841602 (2), 12973153 (2), 11408347 (2) (see all 25)

Search CenterWatch for drugs/clinical trials and news about MTNR1A / MTR1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MTNR1A gene:

NM_005958.3

Unigene Cluster for MTNR1A:

Melatonin receptor 1A

Hs.243467 [show with all ESTs]

Unigene Representative Sequence: BC126297

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000509111 ENST00000307161(uc003izd.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTNR1A
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MTNR1A
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTNR1A (see all 7) OriGene shRNA RFP: MTNR1A OriGene siRNA: MTNR1A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTNR1A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTNR1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTNR1A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MTNR1A (NM_005958)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTNR1A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTNR1A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTNR1A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MTNR1A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTNR1A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTNR1A

Additional cDNA sequence:

AF435588.1 BC074946.2 BC074947.2 BC113816.1 BC126297.1 BC126299.1 EU432127.1 U14108.1

1 DOTS entry:

DT.91748277

23 AceView cDNA sequences:

BC074946 AL703888 BC074947 BX112166 BC038717 AI138290 U14108 NM_005958

AI001834 AF435588 BC034307 CB155561 CB122088 AI204202 BU567547 BI520221

AI126472 BI459826 AI208101 AI221202 BI520849 BU194998 BG719069

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MTNR1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGTATTTCA

About this image

MTNR1A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MTNR1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTNR1A

SOURCE GeneReport for Unigene cluster: Hs.243467

UniProtKB/Swiss-Prot: MTR1A_HUMAN, P48039

Tissue specificity: Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus

SABiosciences Expression via Pathway-Focused PCR Arrays including MTNR1A:

G Protein Coupled Receptors 384HT in human mouse rat

Circadian Rhythms in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTNR1A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MTNR1A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTNR1A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTNR1A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MTNR1A gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mtnr1a^{1 , 5}	melatonin receptor 1A^{1, 5}	81.62(n)¹ 84.86(a)¹		8 (24.95 cM)⁵ 17773¹ NM_008639.2¹ NP_032665.1¹ 45069137⁵
chicken (Gallus gallus)	Aves	MTNR1A¹	melatonin receptor 1A	74.59(n) 80.87(a)		396319 NM_205362.1 NP_990693.1
lizard (Anolis carolinensis)	Reptilia	MTNR1A⁶	--	82(a)	1 ↔ 1	5(111605694-111606563)
African clawed frog (Xenopus laevis)	Amphibia	LOC397808²	Mel-1c receptor subtype	73.72(n)		U67881.1
zebrafish (Danio rerio)	Actinopterygii	mel1ar²	melatonin receptor type 1A z1.7	76.87(n)		30667 AY166824.1
fruit fly (Drosophila melanogaster)	Insecta	moody¹	CG4322-PA	43.43(n) 29.64(a)		31168 NM_001201605.1 NP_001188534.1

ENSEMBL Gene Tree for MTNR1A (if available)
TreeFam Gene Tree for MTNR1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MTNR1A gene

MTNR1B² GPR50²

3 SIMAP similar genes for MTNR1A using alignment to 4 protein entries: MTR1A_HUMAN (see all proteins):

MTNR1B GPR50 OPRM1

MTNR1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Human Gene Mutation Database (HGMD): MTNR1A

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTNR1A

DNA2.0 Custom Variant and Variant Library Synthesis for MTNR1A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MTNR1A for disorders           About GeneDecksing

OMIM gene information: 600665    OMIM disorders: --

17 diseases for MTNR1A:    About MalaCards

tardive dyskinesia autism spectrum disorder oral squamous cell carcinoma squamous cell carcinoma

sleep disorder scoliosis alzheimer's disease rheumatoid arthritis

pertussis arthritis breast cancer obesity

carcinoma schizophrenia adenocarcinoma pancreatitis

neuronitis

1 Novoseek disease relationship for MTNR1A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	21.7	2	11841602 (1), 17316165 (1)

Genetic Association Database (GAD): MTNR1A
Human Genome Epidemiology (HuGE) Navigator: MTNR1A (13 documents)

Export disorders for MTNR1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MTNR1A gene, integrated from 9 sources (see all 99):
(articles sorted by number of sources associating them with MTNR1A)

Utopia: connect your pdf to the dynamic
world of online information

Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). (PubMed id 7558006)^{1, 3, 9} Slaugenhaupt S.A....Reppert S.M. (1995)
Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis. (PubMed id 12973153)^{1, 4, 9} Morcuende J.A....Sheffield V. (2003)
Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders. (PubMed id 10471411)^{1, 2, 9} Ebisawa T.... Yamauchi T. (1999)
Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. (PubMed id 16098099)^{1, 4} Ha E....Hong S.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. (PubMed id 7946354)^{1, 2} Reppert S.M.... Ebisawa T. (1994)
Possible involvement of melatonin in tooth developmen t: expression of melatonin 1a receptor in human and mouse tooth germs. (PubMed id 20372918)^{1, 9} Kumasaka S....Satomura K. (2010)
Mutation screening of melatonin-related genes in pati ents with autism spectrum disorders. (PubMed id 20377855)^{1, 9} Jonsson L....Melke J. (2010)
Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients. (PubMed id 11841602)^{1, 9} Savaskan E....Muller-Spahn F. (2002)
Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. (PubMed id 10598579)^{1, 9} Brydon L....Jockers R. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4543	HGNC: 7463	AceView: MTNR1A	Ensembl:ENSG00000168412	euGenes: HUgn4543
ECgene: MTNR1A	Kegg: 4543	H-InvDB: MTNR1A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MTNR1A	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Melatonin_receptor

Intellectual Property for MTNR1A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MTNR1A gene:
Search GeneIP for patents involving MTNR1A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Purified and/or Recombinant MTNR1A Protein

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for MTNR1A		OriGene shRNA RFP for MTNR1A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTNR1A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTNR1A
	OriGene Protein Over-expression Lysate for MTNR1A		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MTNR1A		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTNR1A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTNR1A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for MTNR1A		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MTNR1A		OriGene Custom Protein Services for MTNR1A
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTNR1A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTNR1A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTNR1A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTNR1A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTNR1A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTNR1A

	GenScript Custom Purified and Recombinant Proteins Services for MTNR1A		GenScript cDNA clones with any tag delivered in your preferred vector for MTNR1A
	GenScript MTNR1A-overexpressing Cell Line for Assay		GenScript Custom Superior Antibodies Services for MTNR1A
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MTNR1A promoter
	Search Chromatin IP Primers for MTNR1A
	RT² qPCR Primer Assay in human, mouse, rat MTNR1A
	Search GNC Networks for MTNR1A
	SABiosciences PCR Arrays including human, mouse, rat MTNR1A

Tocris compounds for MTNR1A

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MTNR1A antibodies
	MTNR1A proteins
	MTNR1A lysates

	Search for Antibodies for MTNR1A at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for MTNR1A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

MTNR1A Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MTNR1A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTNR1A

	Browse SwitchGear 3'UTR luciferase reporter plasmids for MTNR1A
	SwitchGear Promoter luciferase reporter plasmids for MTNR1A

ThermoFisher Antibodies for MTNR1A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTNR1A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MTNR1A gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

MTNR1A Gene

melatonin receptor 1A

Aliases
for MTNR1A gene

Summaries
for MTNR1A gene

Genomic Views
for MTNR1A gene

Proteins
for MTNR1A gene

Protein Domains /
Families
for MTNR1A gene

Function
for MTNR1A gene

Pathways & Interactions
for MTNR1A gene

Drugs & Compounds
for MTNR1A gene

Transcripts
for MTNR1A gene

Expression
for MTNR1A gene

Orthologs
for MTNR1A gene

Paralogs
for MTNR1A gene

Genomic Variants
for MTNR1A gene

Disorders / Diseases
for MTNR1A gene

Publications
for MTNR1A gene

External Searches for MTNR1A gene

Genome Databases showing MTNR1A gene

Other Databases showing MTNR1A gene

Specialized Databases showing MTNR1A gene

Intellectual Property
for MTNR1A gene

Products
for MTNR1A gene

View Random Gene

Advanced Search

Export list of displayed genes

MTNR1A Gene

melatonin receptor 1A

Aliasesfor MTNR1A gene

Summariesfor MTNR1A gene

Genomic Viewsfor MTNR1A gene

Proteinsfor MTNR1A gene

Protein Domains /Familiesfor MTNR1A gene

Functionfor MTNR1A gene

Pathways & Interactionsfor MTNR1A gene

Drugs & Compoundsfor MTNR1A gene

Transcriptsfor MTNR1A gene

Expression for MTNR1A gene

Orthologsfor MTNR1A gene

Paralogsfor MTNR1A gene

Genomic Variantsfor MTNR1A gene

Disorders / Diseasesfor MTNR1A gene

Publicationsfor MTNR1A gene

External Searches for MTNR1A gene

Genome Databases showing MTNR1A gene

Other Databases showing MTNR1A gene

Specialized Databases showing MTNR1A gene

Intellectual Propertyfor MTNR1A gene

Productsfor MTNR1A gene

View Random Gene

Aliases
for MTNR1A gene

Summaries
for MTNR1A gene

Genomic Views
for MTNR1A gene

Proteins
for MTNR1A gene

Protein Domains /
Families
for MTNR1A gene

Function
for MTNR1A gene

Pathways & Interactions
for MTNR1A gene

Drugs & Compounds
for MTNR1A gene

Transcripts
for MTNR1A gene

Expression
for MTNR1A gene

Orthologs
for MTNR1A gene

Paralogs
for MTNR1A gene

Genomic Variants
for MTNR1A gene

Disorders / Diseases
for MTNR1A gene

Publications
for MTNR1A gene

Intellectual Property
for MTNR1A gene

Products
for MTNR1A gene