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Aliases for MTMR7 Gene

Aliases for MTMR7 Gene

  • Myotubularin Related Protein 7 2 3 5
  • EC 63
  • EC 63
  • EC 3.1.3.- 4
  • EC 3.1.3 63

External Ids for MTMR7 Gene

Previous GeneCards Identifiers for MTMR7 Gene

  • GC08M017052
  • GC08M017239
  • GC08M017169
  • GC08M017203
  • GC08M015699
  • GC08M017154

Summaries for MTMR7 Gene

Entrez Gene Summary for MTMR7 Gene

  • This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009]

GeneCards Summary for MTMR7 Gene

MTMR7 (Myotubularin Related Protein 7) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include phosphatase activity and phosphatidylinositol phosphate phosphatase activity. An important paralog of this gene is MTMR2.

UniProtKB/Swiss-Prot for MTMR7 Gene

  • Phosphatase that acts on lipids with a phosphoinositol headgroup.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR7 Gene

Genomics for MTMR7 Gene

Regulatory Elements for MTMR7 Gene

Enhancers for MTMR7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTMR7 on UCSC Golden Path with GeneCards custom track

Promoters for MTMR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTMR7 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTMR7 Gene

17,296,797 bp from pter
17,413,531 bp from pter
116,735 bases
Minus strand

Genomic View for MTMR7 Gene

Genes around MTMR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTMR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTMR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR7 Gene

Proteins for MTMR7 Gene

  • Protein details for MTMR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myotubularin-related protein 7
    Protein Accession:
    Secondary Accessions:
    • A1L4K9
    • B4DG87
    • Q68DX4

    Protein attributes for MTMR7 Gene

    660 amino acids
    Molecular mass:
    75833 Da
    Quaternary structure:
    • Interacts with MTMR6, MTMR8 and MTMR9.

    Alternative splice isoforms for MTMR7 Gene


neXtProt entry for MTMR7 Gene

Proteomics data for MTMR7 Gene at MOPED

Post-translational modifications for MTMR7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTMR7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MTMR7 Gene

Gene Families for MTMR7 Gene

Suggested Antigen Peptide Sequences for MTMR7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 myotubularin phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • Contains 1 myotubularin phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR7: view

Function for MTMR7 Gene

Molecular function for MTMR7 Gene

GENATLAS Biochemistry:
myotubularin related protein 7,only expressed in brain
UniProtKB/Swiss-Prot Function:
Phosphatase that acts on lipids with a phosphoinositol headgroup.

Enzyme Numbers (IUBMB) for MTMR7 Gene

Gene Ontology (GO) - Molecular Function for MTMR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016791 phosphatase activity IEA --
GO:0052866 phosphatidylinositol phosphate phosphatase activity IEA --
genes like me logo Genes that share ontologies with MTMR7: view

Phenotypes for MTMR7 Gene

GenomeRNAi human phenotypes for MTMR7:
genes like me logo Genes that share phenotypes with MTMR7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MTMR7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTMR7 Gene

Localization for MTMR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTMR7 Gene


Subcellular locations from

Jensen Localization Image for MTMR7 Gene COMPARTMENTS Subcellular localization image for MTMR7 gene
Compartment Confidence
cytosol 5

No data available for Gene Ontology (GO) - Cellular Components for MTMR7 Gene

Pathways & Interactions for MTMR7 Gene

genes like me logo Genes that share pathways with MTMR7: view

Gene Ontology (GO) - Biological Process for MTMR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 9736772
GO:0006644 phospholipid metabolic process TAS --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 9736772
GO:0046855 inositol phosphate dephosphorylation IEA --
genes like me logo Genes that share ontologies with MTMR7: view

No data available for SIGNOR curated interactions for MTMR7 Gene

Drugs & Compounds for MTMR7 Gene

(1) Drugs for MTMR7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NAD Pharma Full agonist, Agonist 0

(7) Additional Compounds for MTMR7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Beta-D-Fructose 2-phosphate
  • beta-D-Fructofuranose 2-phosphate
  • beta-D-Fructose 2-phosphate
  • beta-D-Arabino-hexulose
  • beta-D-Fructofuranose
  • beta-D-Fructose
  • beta-delta-Arabino-hexulose
  • beta-delta-Fructofuranose
N-Acetyl-D-mannosamine 6-phosphate
  • ManNAc-6-P
  • N-Acetyl-D-mannosamine 6-phosphate
  • N-Acetyl-D-mannosamine-6-P
  • N-Acetyl-D-mannosamine-6-phosphate
  • N-Acetylmannosamine-6-P
  • 2-Acetamido-2-deoxy-D-mannopyranose
  • 2-Acetamido-2-deoxy-D-mannose
  • ManNAc
  • N-Acetyl-D-mannosamine
  • N-Acetylmannosamine
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
genes like me logo Genes that share compounds with MTMR7: view

Transcripts for MTMR7 Gene

Unigene Clusters for MTMR7 Gene

Myotubularin related protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -
SP4: - -

Relevant External Links for MTMR7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTMR7 Gene

mRNA expression in normal human tissues for MTMR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTMR7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.7), and Brain - Cerebellar Hemisphere (x4.6).

Protein differential expression in normal tissues from HIPED for MTMR7 Gene

This gene is overexpressed in Retina (31.3), Frontal cortex (26.6), and Fetal Brain (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTMR7 Gene

SOURCE GeneReport for Unigene cluster for MTMR7 Gene Hs.625674

mRNA Expression by UniProt/SwissProt for MTMR7 Gene

Tissue specificity: Expressed specifically in brain.
genes like me logo Genes that share expression patterns with MTMR7: view

Protein tissue co-expression partners for MTMR7 Gene

- Elite partner

Primer Products

Orthologs for MTMR7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MTMR7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MTMR7 35
  • 90.2 (n)
  • 94.7 (a)
MTMR7 36
  • 95 (a)
(Canis familiaris)
Mammalia MTMR7 35
  • 91.72 (n)
  • 96.06 (a)
MTMR7 36
  • 78 (a)
(Mus musculus)
Mammalia Mtmr7 35
  • 88.94 (n)
  • 94.55 (a)
Mtmr7 16
Mtmr7 36
  • 95 (a)
(Pan troglodytes)
Mammalia MTMR7 35
  • 97.22 (n)
  • 96.52 (a)
MTMR7 36
  • 99 (a)
(Monodelphis domestica)
Mammalia MTMR7 36
  • 86 (a)
(Gallus gallus)
Aves MTMR7 35
  • 79.48 (n)
  • 87.99 (a)
MTMR7 36
  • 87 (a)
(Anolis carolinensis)
Reptilia MTMR7 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr7 35
  • 74.25 (n)
  • 81.79 (a)
(Danio rerio)
Actinopterygii -- 35
mtmr7a 35
  • 66.46 (n)
  • 65.58 (a)
mtmr7a 36
  • 65 (a)
mtmr7b 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3530 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea mtm-6 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR1 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for MTMR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTMR7 Gene

Gene Tree for MTMR7 (if available)
Gene Tree for MTMR7 (if available)

Paralogs for MTMR7 Gene

Paralogs for MTMR7 Gene

(6) SIMAP similar genes for MTMR7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MTMR7: view

Variants for MTMR7 Gene

Sequence variations from dbSNP and Humsavar for MTMR7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3764796 - 17,300,168(+) TCACT(A/G/T)TGCTT reference, missense
VAR_059779 -
rs2051659 -- 17,329,459(+) TTCTT(C/T)AGAAA intron-variant
rs2051660 -- 17,321,883(+) GACAA(A/C)AGATA intron-variant
rs2051661 -- 17,321,970(+) TATAC(C/T)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTMR7 Gene

Variant ID Type Subtype PubMed ID
nsv831245 CNV Gain 17160897
nsv890556 CNV Loss 21882294
nsv518761 CNV Loss 19592680
nsv890557 CNV Loss 21882294
nsv465588 CNV Loss 19166990
esv270628 CNV Insertion 20981092
esv272688 CNV Insertion 20981092
nsv470200 CNV Loss 18288195
nsv465589 CNV Loss 19166990
nsv465590 CNV Loss 19166990
esv6536 OTHER Inversion 19470904
nsv6097 CNV Insertion 18451855
esv4778 CNV Deletion 18987735
esv2736687 CNV Deletion 23290073
esv8254 CNV Loss 19470904
nsv396808 CNV Loss 16902084

Variation tolerance for MTMR7 Gene

Residual Variation Intolerance Score: 2.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MTMR7 Gene

Disorders for MTMR7 Gene

Relevant External Links for MTMR7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MTMR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTMR7 Gene

Publications for MTMR7 Gene

  1. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. (PMID: 9736772) Laporte J. … Mandel J.-L. (Hum. Mol. Genet. 1998) 2 3 4 67
  2. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. (PMID: 12890864) Mochizuki Y. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk. (PMID: 22137330) Sanchez-Juan P. … van Duijn C.M. (Neurobiol. Aging 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for MTMR7 Gene

Sources for MTMR7 Gene