Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MTMR7 Gene

protein-coding   GIFtS: 56
GCID: GC08M017154

Myotubularin Related Protein 7

  Search for MTMR7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myotubularin Related Protein 71 2
Myotubularin-Related Protein 72
EC 3.1.3.-3
EC 3.1.38
EC 3.1.3.188
EC 3.1.3.488

External Ids:    HGNC: 74541   Entrez Gene: 91082   Ensembl: ENSG000000039877   OMIM: 6035625   UniProtKB: Q9Y2163   

Export aliases for MTMR7 gene to outside databases

Previous GC identifers: GC08M017052 GC08M017239 GC08M017169 GC08M017203 GC08M015699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MTMR7 Gene:
This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded
protein is characterized by four distinct domains that are conserved among all members of the myotubularin
family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment
domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of
variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target
substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on
chromosome 5. (provided by RefSeq, Mar 2009)

GeneCards Summary for MTMR7 Gene:
MTMR7 (myotubularin related protein 7) is a protein-coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is MTMR4.

UniProtKB/Swiss-Prot: MTMR7_HUMAN, Q9Y216
Function: Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTMR7 gene promoter:
         AML1a   MyoD   Nkx2-5   XBP-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   POU2F1   POU2F1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTMR7 promoter sequence
   Search Chromatin IP Primers for MTMR7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTMR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

MTMR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTMR7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M017154:  view genomic region     (about GC identifiers)

Start:
17,154,306 bp from pter      End:
17,271,040 bp from pter
Size:
116,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MTMR7_HUMAN, Q9Y216 (See protein sequence)
Recommended Name: Myotubularin-related protein 7  
Size: 660 amino acids; 75833 Da
Subunit: Interacts with MTMR6, MTMR8 and MTMR9
Secondary accessions: A1L4K9 B4DG87 Q68DX4
Alternative splicing: 2 isoforms:  Q9Y216-1   Q9Y216-2   

Explore the universe of human proteins at neXtProt for MTMR7: NX_Q9Y216

Explore proteomics data for MTMR7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MTMR7 (Q9Y216) (see all 11)
     LQAIRKA  VGSSKFRS  FEFNERFL  WISFGHKF 


    See MTMR7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004677.3  
    ENSEMBL proteins: 
     ENSP00000180173   ENSP00000429733   ENSP00000431000   ENSP00000381171  
    Reactome Protein details: Q9Y216

    MTMR7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MTMR7
    OriGene Protein Over-expression Lysate for MTMR7
    OriGene MassSpec for MTMR7
    OriGene Custom Protein Services for MTMR7
    GenScript Custom Purified and Recombinant Proteins Services for MTMR7
    Novus Biologicals MTMR7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTMR7

     
    Search eBioscience for Proteins for MTMR7 

    MTMR7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MTMR7
    Novus Biologicals MTMR7 Antibody
    Abcam antibodies for MTMR7
    Cloud-Clone Corp. Antibodies for MTMR7
    ThermoFisher Antibodies for MTMR7
    Search LSBio for Antibodies for MTMR7

    MTMR7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTMR7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTMR7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTMR7
    Cloud-Clone Corp. CLIAs for MTMR7
    Search eBioscience for ELISAs for MTMR7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DUSPM: Protein tyrosine phosphatases / Class I Cys-based PTPs : Myotubularins

    5 InterPro protein domains:
     IPR017906 Myotubularin_phosphatase_dom
     IPR010569 Myotubularin-like_Pase_dom
     IPR016130 Tyr_Pase_AS
     IPR011993 PH_like_dom
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q9Y216

    ProtoNet protein and cluster: Q9Y216

    1 Blocks protein domain: IPB010569 Myotubularin-related

    UniProtKB/Swiss-Prot: MTMR7_HUMAN, Q9Y216
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily
    Similarity: Contains 1 myotubularin phosphatase domain


    Find genes that share domains with MTMR7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTMR7_HUMAN, Q9Y216
    Function: Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable)

         Genatlas biochemistry entry for MTMR7:
    myotubularin related protein 7,only expressed in brain

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.482 EC 3.1.3.-1 EC 3.1.3.182

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with MTMR7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MTMR7:
     Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTMR7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTMR7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTMR7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTMR7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MTMR7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTMR7 (see all 17):
    hsa-miR-623 hsa-miR-4328 hsa-miR-4263 hsa-miR-570 hsa-miR-10b* hsa-miR-3161 hsa-miR-204 hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidMTMR7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTMR7
    Predesigned siRNA for gene silencing in human, mouse, rat MTMR7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTMR7

    Clone
    Products:
         
    OriGene clones in human, mouse for MTMR7 (see all 7)
    OriGene ORF clones in mouse, rat for MTMR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTMR7 (NM_004686)
    Sino Biological Human cDNA Clone for MTMR7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTMR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTMR7
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTMR7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MTMR7_HUMAN, Q9Y216: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    Find genes that share ontologies with MTMR7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MTMR7 About    
    See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the late endosome membrane0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64


    Find genes that share SuperPaths with MTMR7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MTMR7
        Synthesis of PIPs at the late endosome membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTMR7
    Interactions:

        GeneGlobe Interaction Network for MTMR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTMR7 (Q9Y2163 ENSP000001801734) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTMR9Q96QG73, ENSP000002210864I2D: score=3 STRING: ENSP00000221086
    PIKFYVEENSP000002643804STRING: ENSP00000264380
    VAC14ENSP000002617764STRING: ENSP00000261776
    HK2ENSP000002905734STRING: ENSP00000290573
    HK3ENSP000002924324STRING: ENSP00000292432
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS9736772
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS9736772

    Find genes that share ontologies with MTMR7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTMR7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MTMR7 gene: 
    NM_004686.4  

    Unigene Cluster for MTMR7:

    Myotubularin related protein 7
    Hs.625674  [show with all ESTs]
    Unigene Representative Sequence: NM_004686
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000180173(uc011kya.2 uc011kyb.2 uc003wxm.3) ENST00000521857(uc003wxn.3)
    ENST00000519590 ENST00000519763 ENST00000517317 ENST00000519122 ENST00000518272
    ENST00000523571 ENST00000521177 ENST00000398099
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTMR7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTMR7 (see all 17):
    hsa-miR-623 hsa-miR-4328 hsa-miR-4263 hsa-miR-570 hsa-miR-10b* hsa-miR-3161 hsa-miR-204 hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidMTMR7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTMR7
    Predesigned siRNA for gene silencing in human, mouse, rat MTMR7
    Clone
    Products:
         
    OriGene clones in human, mouse for MTMR7 (see all 7)
    OriGene ORF clones in mouse, rat for MTMR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTMR7 (NM_004686)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTMR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MTMR7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTMR7
      QuantiTect SYBR Green Assays in human, mouse, rat MTMR7
      QuantiFast Probe-based Assays in human, mouse, rat MTMR7

    Additional mRNA sequence: 

    AF073482.1 AK123201.1 AK294468.1 AK303762.1 AK303803.1 AK316022.1 AK316283.1 BC130577.1 
    BC130579.1 CR749240.1 

    7 DOTS entries:

    DT.100740206  DT.437095  DT.40260165  DT.97774519  DT.99992327  DT.40293001  DT.95359466 

    Selected AceView cDNA sequences (see all 31):

    Z41938 Z38231 BQ025062 BE503993 AL120353 BF056429 BM353520 AK123201 
    CR749240 BM991688 AW510955 AA059046 BE503190 BM668308 AW014721 AF073482 
    CB993268 BE929281 M85620 BU952518 AV730977 BU951075 AA020868 BM680654 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MTMR7    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                          -           -                                                         
    SP2:                                      -                                                         
    SP3:                                                                                                
    SP4:        -                 -                                                                     


    ECgene alternative splicing isoforms for MTMR7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MTMR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MTMR7 Expression
    About this image


    MTMR7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Corneal Stroma
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
    MTMR7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTMR7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.625674

    UniProtKB/Swiss-Prot: MTMR7_HUMAN, Q9Y216
    Tissue specificity: Expressed specifically in brain

        Custom PCR Arrays for MTMR7
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MTMR7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTMR7
    QuantiTect SYBR Green Assays in human, mouse, rat MTMR7
    QuantiFast Probe-based Assays in human, mouse, rat MTMR7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MTMR7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtmr71 , 5 myotubularin related protein 71, 5 88.94(n)1
    94.55(a)1
      8 (23.89 cM)5
    543841  NM_001040699.11  NP_001035789.11 
     405510955 
    chicken
    (Gallus gallus)
    Aves MTMR71 myotubularin related protein 7 79.48(n)
    87.99(a)
      422731  XM_420686.4  XP_420686.4 
    lizard
    (Anolis carolinensis)
    Reptilia MTMR76
    myotubularin related protein 7
    86(a)
    1 ↔ 1
    5(108260003-108318049)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mtmr71 myotubularin related protein 7 74.25(n)
    81.79(a)
      100485851  XM_002940449.2  XP_002940495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053411.12   -- 72.75(n)   393365  BC053411.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35306
    --
    41(a)
    1 → many
    2R(19276524-19284202)
    worm
    (Caenorhabditis elegans)
    Secernentea mtm-66
    Protein MTM-6, isoform b (mtm-6) mRNA, complete cd...
    34(a)
    1 → many
    III(13347085-13356367) WBGene00003478
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YMR16
    Phosphatidylinositol 3-phosphate (PI3P) phosphatas...
    30(a)
    1 → many
    X(633615-635681) YJR110W


    ENSEMBL Gene Tree for MTMR7 (if available)
    TreeFam Gene Tree for MTMR7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MTMR7 gene
    MTMR42  MTMR122  MTMR22  MTMR102  MTM12  MTMR82  MTMR32  MTMR62  
    SBF22  MTMR92  MTMR112  SBF12  MTMR12  
    6 SIMAP similar genes for MTMR7 using alignment to 4 protein entries:     MTMR7_HUMAN (see all proteins):
    MTMR8    MTMR6    MTM1    MTMR2    MTMR9    MTMR1

    Find genes that share paralogs with MTMR7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MTMR7 (see all 3548)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998197621,2
    Cuntested117198899(+) TAAACG/AAAGTC 2 /F syn11Minor allele frequency- A:0.00EU 1323
    rs1928886561,2
    --17156055(+) CCATTA/TAAAAA 1 -- ut310--------
    rs22461211,2
    C,F,A--17156293(+) TAGGGG/CAGGGA 1 -- ut31 ese3 trp37Minor allele frequency- C:0.46NA WA CSA EA 365
    rs22852711,2
    C,F--17156298(+) GAGGGA/GCTCTC 1 -- ut31 trp35Minor allele frequency- G:0.28NA WA EA 362
    rs1832058761,2
    --17156303(+) ACTCTC/TCCTTA 1 -- ut310--------
    rs1417202611,2
    C--17156385(+) GGTTAA/CTTAAA 1 -- ut310--------
    rs284342341,2
    C,F,H--17156393(+) AAACCA/GTATTA 1 -- ut3117Minor allele frequency- G:0.12NS EA NA WA 2338
    rs1882744391,2
    --17156410(+) TACATA/CATTTC 1 -- ut310--------
    rs1911251871,2
    --17156572(+) CTGTCA/GGTAGT 1 -- ut310--------
    rs1172994911,2
    F--17156603(+) AAAAGG/ATTATT 1 -- ut311Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for MTMR7 (17154306 - 17271040 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MTMR7 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736687CNV Deletion23290073
    esv4778CNV Deletion18987735
    esv272688CNV Insertion20981092
    nsv6097CNV Insertion18451855
    esv270628CNV Insertion20981092
    nsv470200CNV Loss18288195
    nsv890557CNV Loss21882294
    nsv465590CNV Loss19166990
    nsv518761CNV Loss19592680
    nsv890556CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTMR7
    DNA2.0 Custom Variant and Variant Library Synthesis for MTMR7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603562    OMIM disorders: --


    Find genes that share disorders with MTMR7           About GenesLikeMe

    Genetic Association Database (GAD): MTMR7
    Human Genome Epidemiology (HuGE) Navigator: MTMR7 (1 document)

    Export disorders for MTMR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MTMR7 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with MTMR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. (PubMed id 9736772)1, 2, 3 Laporte J....Mandel J.-L. (Hum. Mol. Genet. 1998)
    2. Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk. (PubMed id 22137330)1, 4 Sanchez-Juan P....van Duijn C.M. (Neurobiol. Aging 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. (PubMed id 12890864)1, 3 Mochizuki Y. and Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    8. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. (PubMed id 16787938)2 Lorenzo O.... Clague M.J. (J. Cell Sci. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9108 HGNC: 7454 AceView: MTMR7 Ensembl:ENSG00000003987 euGenes: HUgn9108
    ECgene: MTMR7 H-InvDB: MTMR7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MTMR7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MTMR7 gene:
    Search GeneIP for patents involving MTMR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MTMR7  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MTMR7  
     OriGene MassSpec something-or-other for MTMR7   OriGene clones in human, mouse for MTMR7  
     OriGene qSTAR qPCR primer pairs in human, mouse for MTMR7   OriGene Purified Protein for MTMR7  
     OriGene ORF clones in mouse, rat for MTMR7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MTMR7   OriGene Custom Protein Services for MTMR7  

     
     
     Block miRNA regulation of human, mouse, rat MTMR7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MTMR7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTMR7 Predesigned siRNA for gene silencing in human, mouse, rat MTMR7
     QuantiFast Probe-based Assays in human, mouse, rat MTMR7 QuantiTect SYBR Green Assays in human, mouse, rat MTMR7
     Custom PCR Arrays for MTMR7 Search Chromatin IP Primers for MTMR7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTMR7  GeneGlobe Interaction Network for MTMR7
     Regulatory tfbs in MTMR7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MTMR7 GenScript cDNA clones with any tag delivered in your preferred vector for MTMR7
     GenScript Custom Assay Services for MTMR7 GenScript Custom overexpressing Cell Line Services for MTMR7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MTMR7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MTMR7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MTMR7 antibodies
     MTMR7 lysates
     Antibodies for MTMR7
     See all of Abcam's Antibodies, Kits and Proteins for MTMR7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MTMR7
     Antibodies for MTMR7
     ELISAs for MTMR7
     CLIAs for MTMR7



     Browse ESI BIO Cell Lines and PureStem Progenitors for MTMR7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR7
     SwitchGear 3'UTR luciferase reporter plasmids for MTMR7
     SwitchGear Promoter luciferase reporter plasmids for MTMR7
     ThermoFisher Antibodies for MTMR7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTMR7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTMR7
     Search LSBio for Antibodies for MTMR7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MTMR7
      Search eBioscience for proteins for MTMR7
      Search eBioscience for elisas for MTMR7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MTMR7 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4