Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTMR6 Gene

protein-coding   GIFtS: 60
GCID: GC13M025820

myotubularin related protein 6
 Explore 4 diseases affiliated with
MTMR6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MTMR6    

Aliases
for MTMR6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myotubularin Related Protein 61 2
Myotubularin-Related Protein 62
EC 3.1.3.-3
EC 3.1.38
EC 3.1.3.488

External Ids:    HGNC: 74531   Entrez Gene: 91072   Ensembl: ENSG000001395057   OMIM: 6035615   UniProtKB: Q9Y2173   

Export aliases for MTMR6 gene to outside databases

Previous GC identifers: GC13M023801 GC13M019801 GC13M024732 GC13M023619 GC13M024719 GC13M006634


Summaries
for MTMR6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217
Function: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of
KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3
phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells

Gene Wiki entry for MTMR6


Genomic Views
for MTMR6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTMR6 gene promoter:
         STAT1   POU6F1 (c2)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   En-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MTMR6 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTMR6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTMR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12

MTMR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTMR6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M025820:  view genomic region     (about GC identifiers)

Start:
 25,802,307 bp from pter      End:
 25,862,147 bp from pter
Size:
 59,841 bases      Orientation:
 minus strand

Proteins
for MTMR6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217 (See protein sequence)
Recommended Name: Myotubularin-related protein 6  
Size: 621 amino acids; 71968 Da
Subunit: Interacts with KCNN4, MTMR7, MTMR8 and MTMR9
Subcellular location: Nucleus envelope
1 PDB 3D structure from and Proteopedia for MTMR6:
2YF0 (3D)    
Secondary accessions: B2RBB5 B3KSB4 Q5JRG6 Q86TB7 Q86YH4 Q96P80
Alternative splicing: 2 isoforms:  Q9Y217-1   Q9Y217-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTMR6: NX_Q9Y217

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y217

    • 4/9 DME Specific Peptides for MTMR6 (Q9Y217) (see all 9)
     LDSYYRT  VGSSKFRS  WISFGHKF  SCQFGNFL 

    MTMR6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004676.3  
    ENSEMBL proteins: 
     ENSP00000371221   ENSP00000443161  
    Reactome Protein details: Q9Y217
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MTMR6
    OriGene Protein Over-expression Lysate: MTMR6
    OriGene Custom Protein Services for MTMR6 
    GenScript Custom Purified and Recombinant Proteins Services for MTMR6
    Novus Biologicals MTMR6 Protein
    Novus Biologicals MTMR6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MTMR6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    MTMR6 for ontologies           About GeneDecksing



    MTMR6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MTMR6 
    GenScript Custom Superior Antibodies Services for MTMR6
    Novus Biologicals MTMR6 Antibodies
    Search for Antibodies for MTMR6 at Abcam  
    Uscn Antibodies for MTMR6
    ThermoFisher Antibodies for MTMR6

    Assay Products for MTMR6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTMR6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MTMR6

    Protein Domains /
    Families
    for MTMR6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MTMR6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017906 Myotubularin_phosphatase_dom
     IPR010569 Myotub-related
     IPR016130 Tyr_Pase_AS
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y217

    ProtoNet protein and cluster: Q9Y217

    1 Blocks protein family: IPB010569 Myotubularin-related

    UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily
    Similarity: Contains 1 myotubularin phosphatase domain


    Function
    for MTMR6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217
    Function: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of
    KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3
    phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells

         Genatlas biochemistry entry for MTMR6:
    myotubularin related protein 6,ubiquitously expressed

    Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.482 EC 3.1.3.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MTMR6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTMR6
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate MTMR6 (see all 54):
    hsa-miR-548j hsa-miR-2052 hsa-miR-548k hsa-miR-485-3p hsa-miR-301a hsa-miR-342-3p hsa-miR-124 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: MTMR6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTMR6 (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTMR6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MTMR6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MTMR6 (NM_004685)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTMR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MTMR6
    Search LifeMap BioReagents cell lines for MTMR6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR6

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity NAS9736772
    GO:0004725protein tyrosine phosphatase activity NAS9736772
    GO:0015269calcium-activated potassium channel activity IDA15831468


    MTMR6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MTMR6:
     Increased apoptosis 


    Pathways & Interactions
    for MTMR6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    2PI Metabolism
    		PI Metabolism1.00
    		Synthesis of PIPs at the plasma membrane0.66
    3Fructose and mannose metabolism
    		Fructose and mannose metabolism1.00
    4Glycerophospholipid biosynthesis
    		Phospholipid metabolism0.64

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for MTMR6
        Metabolism
    Synthesis of PIPs at the plasma membrane
    Phospholipid metabolism
    Metabolism of lipids and lipoproteins
    PI Metabolism


    1         Kegg Pathway  (Kegg details for MTMR6):
        Fructose and mannose metabolism


    MTMR6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTMR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for MTMR6 (Q9Y2173 ENSP000003712214) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTMR9Q96QG73, ENSP000002210864I2D: score=4 STRING: ENSP00000221086
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    PI4K2AENSP000003596654STRING: ENSP00000359665
    SYNJ1ENSP000003222344STRING: ENSP00000322234
    SYNJ2ENSP000003477924STRING: ENSP00000347792
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation NAS9736772
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0035335peptidyl-tyrosine dephosphorylation NAS9736772
    GO:0044281small molecule metabolic process TAS--


    MTMR6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MTMR6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MTMR6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTMR6
    2 Novoseek chemical compound relationships for MTMR6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 3-phosphate 89.8 11 15831468 (2), 16914545 (1), 16251351 (1)
    lipid 19.4 2 15831468 (1), 19038970 (1)

    Search CenterWatch for drugs/clinical trials and news about MTMR6 

    Transcripts
    for MTMR6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MTMR6 gene: 
    NM_004685.3  

    Unigene Cluster for MTMR6:

    Myotubularin related protein 6
    Hs.643702  [show with all ESTs]
    Unigene Representative Sequence: NM_004685
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381801(uc001uqf.4) ENST00000482345(uc021rhj.1) ENST00000540661(uc001uqe.1 uc021rhi.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: MTMR6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTMR6
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate MTMR6 (see all 54):
    hsa-miR-548j hsa-miR-2052 hsa-miR-548k hsa-miR-485-3p hsa-miR-301a hsa-miR-342-3p hsa-miR-124 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: MTMR6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTMR6 (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTMR6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MTMR6 (NM_004685)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTMR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTMR6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTMR6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTMR6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTMR6

    Additional cDNA sequence: 

    AF072928.1 AF406619.1 AK025507.1 AK314587.1 AL832017.2 BC031834.1 BC035436.1 BC040012.1 
    EF491793.1 EF491817.1 U47635.1 

    8 DOTS entries:

    DT.117217  DT.100731831  DT.40116937  DT.95176181  DT.120761802  DT.120761813  DT.117219  DT.95176205 

    24/198 AceView cDNA sequences (see all 198):

    BM799774 BM719130 BM693200 BX097604 Z39074 AW615067 CB119683 BX371371 
    AI217727 BM799643 BM053121 BX353169 BM053082 BP362569 BM558706 AA687240 
    NM_004685 BM053081 CK903989 AA373206 AL119215 U47635 AA911086 H19468 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MTMR6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
    SP1:                                                                                -                                 
    SP2:                          -                                                                                       
    SP3:                                                                                                                  


    ECgene alternative splicing isoforms for MTMR6

    Expression
    for MTMR6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTMR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MTMR6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MTMR6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTMR6

    SOURCE GeneReport for Unigene cluster: Hs.643702

    UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217
    Tissue specificity: Expressed in CD4+ T-cells

        SABiosciences Custom PCR Arrays for MTMR6
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTMR6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTMR6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTMR6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTMR6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR6

    Orthologs
    for MTMR6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MTMR6 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MTMR61 myotubularin related protein 6 78.87(n)
    86.13(a)    		   418938  XM_417132.3  XP_417132.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MTMR66
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343306.1(53918-67772)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi04a112 wufi04a11 75.8(n)   327346  BC044359.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BcDNA:GH046373 protein amino acid dephosphorylation protein
    tyrosine/serine/threonine more    		 53(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea T24A11.1a3   -- 36(a)
    (best of 2)    		   III(3862420-3871844)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes YMR11 Ymr1p 49.72(n)
    40.79(a)    		   853574   NP_012644.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MTM16
    AT5G045406
    		 Myotubularin-like phosphatases II-like protein
    		 21(a)
    21(a)
    		 many ↔ many
    many ↔ many
    		 3(3292899-3298522)
    5(1296442-1302444)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 inositol or phosphatidylinositol phosphatase/ phos...
    		 22(a)
    		 1 → many
    		 8(27856282-27865603)


    ENSEMBL Gene Tree for MTMR6 (if available)
    TreeFam Gene Tree for MTMR6 (if available) 

    Paralogs
    for MTMR6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTMR6 gene
    MTMR42  MTMR72  MTMR122  MTMR22  MTMR102  MTM12  MTMR82  MTMR32  
    SBF22  MTMR92  MTMR112  SBF12  MTMR12  
    9 SIMAP similar genes for MTMR6 using alignment to 1 protein entry:     MTMR6_HUMAN:
    MTMR7    MTMR8    MTM1    DKFZp434K171    MTMR2    MTMR1
    MTMR9    MTMR3    MTMR4

    MTMR6 for paralogs           About GeneDecksing



    Genomic Variants
    for MTMR6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/772 NCBI SNPs in MTMR6 are shown (see all 772)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1427140341,2
    		--25819847(+) AACCCC/TGTCTC 1 -- ds50010--------
    rs1508151031,2
    		--25819848(+) ACCCCA/GTCTCT 1 -- ds50010--------
    rs95074871,2
    		C,--25819955(+) gaggtT/Cgtggt 1 -- ds50014Minor allele frequency- C:0.15NA EA 244
    rs1427933381,2
    		--25820047(+) AAAAA-/GAAT  
                AATTC     		1 -- ds50010--------
    rs95535671,2
    		C,F,A,H,--25820101(+) ATGGGC/TGGTTT 1 -- ds500135Minor allele frequency- T:0.41NS EA NA CSA WA 3410
    rs95074881,2
    		C,F,H,--25820189(+) TATTGA/C/GTATGC 1 -- ds500118NS EA NA CSA 2357
    rs1478745031,2
    		--25820360(+) ATAAC-/TAGAGTA 1 -- ut310--------
    rs1392446601,2
    		--25820404(+) TCATGC/TTTACA 1 -- ut310--------
    rs164131,2
    		C--25820556(+) TTTCT-/TTAA  
                TTAAT     		2 -- ut315Minor allele frequency- TTAA:0.34EU NA EA CSA 344
    rs1419936141,2
    		C,--25820556(+) TTTCT-/TTAA  
                TTAAT     		1 -- ut310--------

    HapMap Linkage Disequilibrium report for MTMR6 (25802307 - 25862147 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MTMR6
         1 CNV: 101682
         1 Indel: 58617
         1 Inversion: 29491

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTMR6
    DNA2.0 Custom Variant and Variant Library Synthesis for MTMR6

    Disorders / Diseases
    for MTMR6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MTMR6 for disorders           About GeneDecksing

    OMIM gene information: 603561    OMIM disorders: --

    4 diseases for MTMR6:    About MalaCards
    centronuclear myopathy    polycystic kidney disease    kidney disease    myopathy

    2 diseases from the University of Copenhagen DISEASES database for MTMR6:
    Centronuclear myopathy     Charcot-Marie-Tooth disease

    Export disorders for MTMR6 gene to outside databases

    Publications
    for MTMR6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTMR6 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with MTMR6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. (PubMed id 9736772)1, 2, 3 Laporte J....Mandel J.-L. (1998)
    2. The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. (PubMed id 15831468)1, 2, 9 Srivastava S....Skolnik E.Y. (2005)
    3. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. (PubMed id 16847315)1, 2, 9 Srivastava S.... Skolnik E.Y. (2006)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. (PubMed id 12890864)1, 2 Mochizuki Y. and Majerus P.W. (2003)
    8. MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis. (PubMed id 19038970)1, 9 Zou J....Majerus P.W. (2009)
    9. Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. (PubMed id 12646134)1, 9 Schaletzky J....Barr F.A. (2003)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)

    External Searches for MTMR6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MTMR6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9107 HGNC: 7453 AceView: MTMR6 Ensembl:ENSG00000139505 euGenes: HUgn9107
    ECgene: MTMR6 Kegg: 9107 H-InvDB: MTMR6

    Other Databases showing MTMR6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MTMR6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTMR6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MTMR6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MTMR6 gene:
    Search GeneIP for patents involving MTMR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MTMR6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTMR6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTMR6  
     OriGene Protein Over-expression Lysate for MTMR6   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for MTMR6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for MTMR6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MTMR6   OriGene Custom Protein Services for MTMR6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTMR6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTMR6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTMR6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTMR6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTMR6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTMR6
     GenScript Custom Purified and Recombinant Proteins Services for MTMR6 GenScript cDNA clones with any tag delivered in your preferred vector for MTMR6
     GenScript Custom Assay Services for MTMR6 GenScript Custom Superior Antibodies Services for MTMR6
     GenScript Custom overexpressing Cell Line Services for MTMR6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MTMR6 promoter
     Search Chromatin IP Primers for MTMR6
     RT2 qPCR Primer Assay in human, mouse, rat MTMR6
     Search GNC Networks for MTMR6
     SABiosciences Custom PCR Arrays for MTMR6
     Search Tocris compounds for MTMR6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MTMR6 antibodies
     MTMR6 proteins
     MTMR6 lysates
     Search for Antibodies for MTMR6 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MTMR6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MTMR6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MTMR6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR6
     SwitchGear 3'UTR luciferase reporter plasmids for MTMR6
     SwitchGear Promoter luciferase reporter plasmids for MTMR6
     ThermoFisher Antibodies for MTMR6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR6
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MTMR6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4