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MTMR6 Gene

protein-coding   GIFtS: 62
GCID: GC13M025820

Myotubularin Related Protein 6

  Search for MTMR6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myotubularin Related Protein 61 2
Myotubularin-Related Protein 62
EC 3.1.3.-3
EC 3.1.38
EC 3.1.3.488

External Ids:    HGNC: 74531   Entrez Gene: 91072   Ensembl: ENSG000001395057   OMIM: 6035615   UniProtKB: Q9Y2173   

Export aliases for MTMR6 gene to outside databases

Previous GC identifers: GC13M023801 GC13M019801 GC13M024732 GC13M023619 GC13M024719 GC13M006634


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTMR6 Gene:
MTMR6 (myotubularin related protein 6) is a protein-coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity and calcium-activated potassium channel activity. An important paralog of this gene is MTMR7.

UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217
Function: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of
KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol
3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells

Gene Wiki entry for MTMR6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTMR6 gene promoter:
         STAT1   POU6F1 (c2)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   En-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTMR6 promoter sequence
   Search Chromatin IP Primers for MTMR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTMR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12

MTMR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTMR6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M025820:  view genomic region     (about GC identifiers)

Start:
25,802,307 bp from pter      End:
25,862,147 bp from pter
Size:
59,841 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217 (See protein sequence)
Recommended Name: Myotubularin-related protein 6  
Size: 621 amino acids; 71968 Da
Subunit: Interacts with ALKBH4, KCNN4, MTMR7, MTMR8 and MTMR9
1 PDB 3D structure from and Proteopedia for MTMR6:
2YF0 (3D)    
Secondary accessions: B2RBB5 B3KSB4 Q5JRG6 Q86TB7 Q86YH4 Q96P80
Alternative splicing: 2 isoforms:  Q9Y217-1   Q9Y217-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTMR6: NX_Q9Y217

Explore proteomics data for MTMR6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys135, Lys179, Lys253
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MTMR6 (Q9Y217) (see all 9)
     LDSYYRT  VGSSKFRS  WISFGHKF  SCQFGNFL 


    See MTMR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004676.3  
    ENSEMBL proteins: 
     ENSP00000371221   ENSP00000443161  
    Reactome Protein details: Q9Y217

    MTMR6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPM: Protein tyrosine phosphatases / Class I Cys-based PTPs : Myotubularins

    4 InterPro protein domains:
     IPR017906 Myotubularin_phosphatase_dom
     IPR010569 Myotubularin-like_Pase_dom
     IPR016130 Tyr_Pase_AS
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y217

    ProtoNet protein and cluster: Q9Y217

    1 Blocks protein domain: IPB010569 Myotubularin-related

    UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily
    Similarity: Contains 1 myotubularin phosphatase domain


    Find genes that share domains with MTMR6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTMR6_HUMAN, Q9Y217
    Function: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of
    KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol
    3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells

         Genatlas biochemistry entry for MTMR6:
    myotubularin related protein 6,ubiquitously expressed

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.482 EC 3.1.3.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity NAS9736772
    GO:0004725protein tyrosine phosphatase activity NAS9736772
    GO:0015269calcium-activated potassium channel activity IDA15831468
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with MTMR6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MTMR6:
     Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTMR6
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    miRNA
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    miRTarBase miRNAs that target MTMR6:
    hsa-mir-124-3p (MIRT002587), hsa-mir-15b-5p (MIRT046382)

    Block miRNA regulation of human, mouse, rat MTMR6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTMR6 (see all 54):
    hsa-miR-548j hsa-miR-2052 hsa-miR-548k hsa-miR-485-3p hsa-miR-301a hsa-miR-342-3p hsa-miR-124 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidMTMR6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MTMR6
    Predesigned siRNA for gene silencing in human, mouse, rat MTMR6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MTMR6 (NM_004685)
    Sino Biological Human cDNA Clone for MTMR6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTMR6_HUMAN, Q9Y217: Nucleus envelope
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with MTMR6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTMR6 About    
    See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the plasma membrane0.65
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64


    Find genes that share SuperPaths with MTMR6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MTMR6
        Synthesis of PIPs at the plasma membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTMR6
    Interactions:

        Search GeneGlobe Interaction Network for MTMR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTMR6 (Q9Y2173 ENSP000003712214) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTMR9Q96QG73, ENSP000002210864I2D: score=4 STRING: ENSP00000221086
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    PI4K2AENSP000003596654STRING: ENSP00000359665
    HK2ENSP000002905734STRING: ENSP00000290573
    HK3ENSP000002924324STRING: ENSP00000292432
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation NAS9736772
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation NAS9736772

    Find genes that share ontologies with MTMR6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTMR6

    2 Novoseek inferred chemical compound relationships for MTMR6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 3-phosphate 89.8 11 15831468 (2), 16914545 (1), 16251351 (1)
    lipid 19.4 2 15831468 (1), 19038970 (1)



    Find genes that share compounds with MTMR6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTMR6 gene: 
    NM_004685.3  

    Unigene Cluster for MTMR6:

    Myotubularin related protein 6
    Hs.643702  [show with all ESTs]
    Unigene Representative Sequence: NM_004685
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381801(uc001uqf.4) ENST00000482345(uc021rhj.1) ENST00000540661(uc001uqe.1 uc021rhi.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTMR6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTMR6 (see all 54):
    hsa-miR-548j hsa-miR-2052 hsa-miR-548k hsa-miR-485-3p hsa-miR-301a hsa-miR-342-3p hsa-miR-124 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidMTMR6 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MTMR6
      QuantiFast Probe-based Assays in human, mouse, rat MTMR6

    Additional mRNA sequence: 

    AF072928.1 AF406619.1 AK025507.1 AK314587.1 AL832017.2 BC031834.1 BC035436.1 BC040012.1 
    EF491793.1 EF491817.1 U47635.1 

    8 DOTS entries:

    DT.117217  DT.100731831  DT.40116937  DT.95176181  DT.120761802  DT.120761813  DT.117219  DT.95176205 

    Selected AceView cDNA sequences (see all 198):

    CK903989 BM719130 Z39074 BP362569 BM693200 BX097604 BM053082 BM558706 
    AI217727 BX353169 BM799774 BM053081 NM_004685 BX371371 AL119215 AW615067 
    AA687240 AA373206 BM053121 CB119683 BM799643 Z28510 T31986 AI334293 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MTMR6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
    SP1:                                                                                -                                 
    SP2:                          -                                                                                       
    SP3:                                                                                                                  


    ECgene alternative splicing isoforms for MTMR6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTMR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MTMR6 Expression
    About this image


    MTMR6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    MTMR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTMR6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643702

    UniProtKB/Swiss-Prot: MTMR6_HUMAN, Q9Y217
    Tissue specificity: Expressed in CD4+ T-cells

        Custom PCR Arrays for MTMR6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MTMR6 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtmr61 , 5 myotubularin related protein 61, 5 86.28(n)1
    90.76(a)1
      14 (31.62 cM)5
    2191351  NM_144843.41  NP_659092.11 
     602652055 
    chicken
    (Gallus gallus)
    Aves MTMR61 myotubularin related protein 6 78.87(n)
    86.13(a)
      418938  XM_417132.4  XP_417132.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTMR66
    myotubularin related protein 6
    81(a)
    1 ↔ 1
    GL343306.1(50672-75325)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mtmr61 myotubularin related protein 6 71.68(n)
    77.18(a)
      100497758  XM_002940555.2  XP_002940601.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi04a112 wufi04a11 75.8(n)   327346  BC044359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH046373 protein amino acid dephosphorylation
    protein tyrosine/serine/threonine
    more
    53(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T24A11.1a3   -- 36(a)
    (best of 2)
      III(3862420-3871844)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YMR11 YMR1 49.58(n)
    40.55(a)
      853574   NP_012644.1 


    ENSEMBL Gene Tree for MTMR6 (if available)
    TreeFam Gene Tree for MTMR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTMR6 gene
    MTMR72  MTMR42  MTMR122  MTMR22  MTMR102  MTM12  MTMR82  MTMR32  
    SBF22  MTMR92  MTMR112  SBF12  MTMR12  
    9 SIMAP similar genes for MTMR6 using alignment to 1 protein entry:     MTMR6_HUMAN:
    MTMR8    MTMR7    MTM1    DKFZp434K171    MTMR2    MTMR1
    MTMR9    MTMR3    MTMR4

    Find genes that share paralogs with MTMR6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTMR6 (see all 913)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427140341,2
    --25819847(+) AACCCC/TGTCTC 1 -- ds50010--------
    rs1508151031,2
    --25819848(+) ACCCCA/GTCTCT 1 -- ds50010--------
    rs95074871,2
    C,F--25819955(+) gaggtT/Cgtggt 1 -- ds50014Minor allele frequency- C:0.15NA EA 244
    rs1427933381,2
    --25820047(+) AAAAA-/GAAT  
            
    AATTC
    1 -- ds50010--------
    rs95535671,2
    C,F,A,H--25820101(+) ATGGGC/TGGTTT 1 -- ds500135Minor allele frequency- T:0.41NS EA NA CSA WA 3410
    rs95074881,2
    C,F,H--25820189(+) tattgA/C/Gtatgc 1 -- ds500118NS EA NA CSA 2357
    rs1478745031,2
    C--25820360(+) ATAAC-/TAGAGTA 1 -- ut310--------
    rs1392446601,2
    --25820404(+) TCATGC/TTTACA 1 -- ut310--------
    rs164131,2
    C--25820556(+) TTTCT-/TTAA  
            
    TTAAT
    2 -- ut31 cds15Minor allele frequency- TTAA:0.34EU NA EA CSA 344
    rs1419936141,2
    C--25820556(+) TTTCT-/TTAA  
            
    TTAAT
    1 -- ut310--------

    HapMap Linkage Disequilibrium report for MTMR6 (25802307 - 25862147 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MTMR6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2629441CNV Deletion19546169
    esv2747161CNV Deletion23290073
    nsv820184CNV Loss19587683
    nsv526439CNV Loss19592680
    dgv1566n71CNV Gain21882294
    nsv899943CNV Gain21882294
    nsv435952OTHER Inversion17901297

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTMR6
    DNA2.0 Custom Variant and Variant Library Synthesis for MTMR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603561    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for MTMR6:
    Centronuclear myopathy     Charcot-Marie-Tooth disease

    Find genes that share disorders with MTMR6           About GenesLikeMe


    Export disorders for MTMR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTMR6 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with MTMR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. (PubMed id 9736772)1, 2, 3 Laporte J....Mandel J.-L. (Hum. Mol. Genet. 1998)
    2. The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. (PubMed id 15831468)1, 2, 9 Srivastava S....Skolnik E.Y. (Mol. Cell. Biol. 2005)
    3. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. (PubMed id 16847315)1, 2, 9 Srivastava S.... Skolnik E.Y. (Mol. Cell. Biol. 2006)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. (PubMed id 12890864)1, 2 Mochizuki Y. and Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis. (PubMed id 19038970)1, 9 Zou J....Majerus P.W. (J. Biol. Chem. 2009)
    9. Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. (PubMed id 12646134)1, 9 Schaletzky J....Barr F.A. (Curr. Biol. 2003)
    10. Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. (PubMed id 23188820)1 Mochizuki Y....Hamakubo T. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9107 HGNC: 7453 AceView: MTMR6 Ensembl:ENSG00000139505 euGenes: HUgn9107
    ECgene: MTMR6 H-InvDB: MTMR6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MTMR6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MTMR6 gene:
    Search GeneIP for patents involving MTMR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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