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Aliases for MTMR4 Gene

Aliases for MTMR4 Gene

  • Myotubularin Related Protein 4 2 3
  • FYVE Domain-Containing Dual Specificity Protein Phosphatase 2 3 4
  • Zinc Finger FYVE Domain-Containing Protein 11 3 4
  • EC 3.1.3.48 4 63
  • FYVE-DSP2 3 4
  • ZFYVE11 3 4
  • Zinc Finger, FYVE Domain Containing 11 3
  • KIAA0647 4

External Ids for MTMR4 Gene

Previous GeneCards Identifiers for MTMR4 Gene

  • GC17M056311
  • GC17M059048
  • GC17M056908
  • GC17M057041
  • GC17M053921
  • GC17M056566
  • GC17M051927

Summaries for MTMR4 Gene

GeneCards Summary for MTMR4 Gene

MTMR4 (Myotubularin Related Protein 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include phosphatase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is MTMR2.

UniProtKB/Swiss-Prot for MTMR4 Gene

  • Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR4 Gene

Genomics for MTMR4 Gene

Regulatory Elements for MTMR4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTMR4 Gene

Chromosome:
17
Start:
58,489,529 bp from pter
End:
58,518,110 bp from pter
Size:
28,582 bases
Orientation:
Minus strand

Genomic View for MTMR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTMR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR4 Gene

Proteins for MTMR4 Gene

  • Protein details for MTMR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYA4-MTMR4_HUMAN
    Recommended name:
    Myotubularin-related protein 4
    Protein Accession:
    Q9NYA4
    Secondary Accessions:
    • D3DTZ6
    • Q8IV27
    • Q9Y4D5

    Protein attributes for MTMR4 Gene

    Size:
    1195 amino acids
    Molecular mass:
    133353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTMR4 Gene

Proteomics data for MTMR4 Gene at MOPED

Selected DME Specific Peptides for MTMR4 Gene

Post-translational modifications for MTMR4 Gene

  • Ubiquitination at Lys 202 and Lys 257
  • Modification sites at PhosphoSitePlus

Other Protein References for MTMR4 Gene

Antibody Products

Domains & Families for MTMR4 Gene

Suggested Antigen Peptide Sequences for MTMR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYA4

UniProtKB/Swiss-Prot:

MTMR4_HUMAN :
  • Contains 1 myotubularin phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • Contains 1 myotubularin phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with MTMR4: view

Function for MTMR4 Gene

Molecular function for MTMR4 Gene

GENATLAS Biochemistry:
myotubularin related protein 4 ,expressed in brain,related to KIAA0371 putative hyposine phosphatase family
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).

Enzyme Numbers (IUBMB) for MTMR4 Gene

Gene Ontology (GO) - Molecular Function for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 20061380
GO:0016791 phosphatase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MTMR4: view
genes like me logo Genes that share phenotypes with MTMR4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTMR4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MTMR4 Gene

Localization for MTMR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTMR4 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTMR4 Gene COMPARTMENTS Subcellular localization image for MTMR4 gene
Compartment Confidence
extracellular 5
cytosol 4
endosome 4
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005829 cytosol TAS --
GO:0031901 early endosome membrane TAS --
genes like me logo Genes that share ontologies with MTMR4: view

Pathways & Interactions for MTMR4 Gene

genes like me logo Genes that share pathways with MTMR4: view

SIGNOR curated interactions for MTMR4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 9736772
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0014894 response to denervation involved in regulation of muscle adaptation IEA --
genes like me logo Genes that share ontologies with MTMR4: view

Drugs & Compounds for MTMR4 Gene

(3) Additional Compounds for MTMR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MTMR4: view

Transcripts for MTMR4 Gene

Unigene Clusters for MTMR4 Gene

Myotubularin related protein 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTMR4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: - - -
SP2: -
SP3: - - - - - - - - - - - - - - - - - - - -
SP4:
SP5: -
SP6:

ExUns: 19b · 19c · 19d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for MTMR4 Gene

GeneLoc Exon Structure for
MTMR4
ECgene alternative splicing isoforms for
MTMR4

Expression for MTMR4 Gene

mRNA expression in normal human tissues for MTMR4 Gene

Protein differential expression in normal tissues from HIPED for MTMR4 Gene

This gene is overexpressed in Pancreas (42.7), Monocytes (11.2), and Platelet (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTMR4 Gene



SOURCE GeneReport for Unigene cluster for MTMR4 Gene Hs.514373

mRNA Expression by UniProt/SwissProt for MTMR4 Gene

Q9NYA4-MTMR4_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.
genes like me logo Genes that share expression patterns with MTMR4: view

Protein tissue co-expression partners for MTMR4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTMR4 Gene

Orthologs for MTMR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTMR4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTMR4 35
  • 87.56 (n)
  • 89.16 (a)
MTMR4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTMR4 35
  • 92.13 (n)
  • 93.89 (a)
MTMR4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtmr4 35
  • 89.32 (n)
  • 91.76 (a)
Mtmr4 16
Mtmr4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTMR4 35
  • 99.58 (n)
  • 99.58 (a)
MTMR4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtmr4 35
  • 89.37 (n)
  • 91.34 (a)
oppossum
(Monodelphis domestica)
Mammalia MTMR4 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTMR4 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTMR4 35
  • 73.22 (n)
  • 78.39 (a)
MTMR4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTMR4 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr4 35
  • 70.01 (n)
  • 75.72 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc63645 35
zgc:63645 35
  • 68.95 (n)
  • 73.66 (a)
MTMR4 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3632 37
  • 45 (a)
CG3632 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T24A11.1a 37
  • 32 (a)
T24A11.1b 37
  • 31 (a)
Species with no ortholog for MTMR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTMR4 Gene

ENSEMBL:
Gene Tree for MTMR4 (if available)
TreeFam:
Gene Tree for MTMR4 (if available)

Paralogs for MTMR4 Gene

Paralogs for MTMR4 Gene

(9) SIMAP similar genes for MTMR4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MTMR4: view

Variants for MTMR4 Gene

Sequence variations from dbSNP and Humsavar for MTMR4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs887206 -- 58,497,723(+) AACAT(C/G)AGGTT intron-variant
rs1860262 -- 58,503,636(+) CAAAG(C/T)GAGAT intron-variant
rs2007993 -- 58,513,282(+) AAGGG(C/T)AAGGC intron-variant
rs2068710 -- 58,517,174(+) GTCCT(C/G)CTGAG intron-variant, upstream-variant-2KB
rs2108911 -- 58,493,139(+) TGATA(A/C/T)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTMR4 Gene

Variant ID Type Subtype PubMed ID
nsv908641 CNV Loss 21882294

Variation tolerance for MTMR4 Gene

Residual Variation Intolerance Score: 16.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.98; 99.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTMR4 Gene

HapMap Linkage Disequilibrium report
MTMR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTMR4 Gene

Disorders for MTMR4 Gene

Relevant External Links for MTMR4

Genetic Association Database (GAD)
MTMR4
Human Genome Epidemiology (HuGE) Navigator
MTMR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTMR4
genes like me logo Genes that share disorders with MTMR4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTMR4 Gene

Publications for MTMR4 Gene

  1. MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes. (PMID: 20061380) Yu J. … Tang H. (J. Biol. Chem. 2010) 23 67
  2. Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. (PMID: 19329342) Dolley G. … Vohl M.C. (Mol. Genet. Metab. 2009) 23 67
  3. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. (PMID: 19125695) Plant P.J. … Batt J. (Biochem. J. 2009) 23 67
  4. Development of microsatellite markers and comparative mapping for bovine chromosome 19. (PMID: 11849140) Kirkpatrick B.W. … Warren W.C. (Anim. Genet. 2002) 23 67
  5. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. (PMID: 9736772) Laporte J. … Mandel J.-L. (Hum. Mol. Genet. 1998) 2 67

Products for MTMR4 Gene

Sources for MTMR4 Gene

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