MTMR4 Gene
protein-coding GIFtS: 60
GCID: GC17M056566
|
|
myotubularin related protein 4
| |
Aliases
for MTMR4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myotubularin Related Protein 41 2 | | FYVE Domain-Containing Dual Specificity Protein Phosphatase 22 3 | | ZFYVE111 2 3 | | EC 3.1.3.483 8 | | KIAA06471 3 | | Myotubularin-Related Protein 42 | | Zinc Finger FYVE Domain-Containing Protein 112 3 | | Zinc Finger, FYVE Domain Containing 112 | | FYVE-DSP22 3 | | |
Export aliases for MTMR4 gene to outside databasesPrevious GC identifers: GC17M056311 GC17M059048 GC17M056908 GC17M057041 GC17M053921 GC17M051927 |
Summaries
for MTMR4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MTMR4_HUMAN, Q9NYA4Function: Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatasesubstrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3)
|
Genomic Views
for MTMR4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTMR4 gene promoter:
E2F-4 E2F-3a E2F-5 Lmo2 E2F-2 C/EBPalpha CREB E2F E2F-1 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTMR4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTMR4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22-q23 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q22-q23MTMR4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M056566: view genomic region
(about GC identifiers)
Start:
|
56,566,893 bp from pter |
End:
|
56,595,266 bp from pter |
Size:
|
28,374 bases |
Orientation:
|
minus strand |
|
Proteins
for MTMR4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTMR4_HUMAN, Q9NYA4 (See
protein sequence)Recommended Name: Myotubularin-related protein 4 Size: 1195 amino acids; 133353 Da
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region
Developmental stage: Expressed in fetal brain and fetal liver
Secondary accessions: D3DTZ6 Q8IV27 Q9Y4D5Explore the universe of human proteins at neXtProt for MTMR4: NX_Q9NYA4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYA4
3 DME Specific Peptides for MTMR4 (Q9NYA4)
MTMR4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004678.3
ENSEMBL proteins: ENSP00000464067 ENSP00000325285 ENSP00000464247 ENSP00000463479 ENSP00000462869 ENSP00000463259 ENSP00000464588 Reactome Protein details: Q9NYA4
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MTMR4 for ontologies About GeneDecksing
MTMR4 Antibody Products:
Assay Products for MTMR4: |
Protein
Domains /
Families
for MTMR4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTMR4 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9NYA4ProtoNet protein and cluster: Q9NYA4 2 Blocks protein families: IPB000306 Zn-finger IPB010569 Myotubularin-related
UniProtKB/Swiss-Prot: MTMR4_HUMAN, Q9NYA4Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamilySimilarity: Contains 1 FYVE-type zinc fingerSimilarity: Contains 1 myotubularin phosphatase domain |
Function
for MTMR4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MTMR4_HUMAN, Q9NYA4Function: Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatasesubstrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3)Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Genatlas biochemistry entry for MTMR4:myotubularin related protein 4 ,expressed in brain,related to KIAA0371 putative hyposine phosphatase family
Enzyme Number (IUBMB): EC 3.1.3.481 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MTMR4 (NM_004687) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTMR4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004722 | protein serine/threonine phosphatase activity |
TAS | -- | | GO:0004725 | protein tyrosine phosphatase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
MTMR4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MTMR4:
|
Pathways & Interactions
for MTMR4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | TGF-beta receptor signaling activates SMADs | | | 3 | Synthesis of PIPs at the Golgi membrane | | | 4 | PI Metabolism | | | 5 | Glycerophospholipid biosynthesis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 
Reactome Pathways for MTMR4 (see all 10)
MTMR4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTMR4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/14 Interacting proteins for MTMR4 (Q9NYA42, 3 ENSP000003252854) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006470 | protein dephosphorylation |
TAS | 9736772 | | GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006661 | phosphatidylinositol biosynthetic process |
TAS | -- | | GO:0007179 | transforming growth factor beta receptor signaling pathway |
TAS | -- | | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
TAS | -- |
MTMR4 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTMR4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTMR4
1 HMDB Compound for MTMR4 About this table
Search CenterWatch for drugs/clinical trials and news about MTMR4
|
Transcripts
for MTMR4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTMR4 gene: NM_004687.4 Unigene Cluster for MTMR4: Myotubularin related protein 4 Hs.514373 [show with all ESTs]Unigene Representative Sequence: NM_00468710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579925 ENST00000323456(uc002iwj.2) ENST00000578259 ENST00000580983
ENST00000582663 ENST00000583966 ENST00000583656 ENST00000582390(uc010dcx.1)
ENST00000579921 ENST00000583243
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MTMR4 (NM_004687) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTMR4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR4 |
Additional cDNA sequence: AB014547.2 AF264717.1 AK308877.1 BC035609.1 14 DOTS entries: DT.444297 DT.91751412 DT.120975244 DT.75119836 DT.100682219 DT.102822337 DT.91751395 DT.97766551 DT.100783201 DT.102822338 DT.86846464 DT.91712526 DT.95171953 DT.95112364 24/271 AceView cDNA sequences (see all 271): AI753511 BF589239 BU539776 AW104599 BM792948 AA582105 AI538945 AI091664 AI654535 BM730015 AW902006 F01785 F03755 AI051833 BM981972 AI143629 T30116 AI123152 BP371957 BM454531 BE891079 BF059644 BU181176 AI368195
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MTMR4 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | · | 19c | · | 19d |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for MTMR4
|
Expression
for MTMR4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTMR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATGTGCTG
About this image
See MTMR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTMR4
SOURCE GeneReport for Unigene cluster: Hs.514373
UniProtKB/Swiss-Prot: MTMR4_HUMAN, Q9NYA4Tissue specificity: Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland,pancreas, ovary, prostate, skin, peripheral blood, and bone marrow
SABiosciences Custom PCR Arrays for MTMR4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTMR4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTMR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTMR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTMR4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR4 |
Orthologs
for MTMR4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MTMR4 gene from 8/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MTMR41 |
myotubularin related protein 4 |
73.05(n)
77.85(a) |
|
417472 XM_415720.3 XP_415720.2 |
lizard
(Anolis carolinensis) |
Reptilia |
MTMR46 |
-- |
88(a) |
1 ↔ 1 |
GL344704.1(10438-21912) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC045024.12 |
-- |
77.22(n) |
|
BC045024.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636452 |
hypothetical protein MGC63645 |
79.76(n) |
|
393584 BC056794.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG36323 |
protein amino acid dephosphorylation protein
tyrosine/serine/threonine more |
45(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
T24A11.1a3
mtm-31 |
Protein MTM-31 |
32(a)
(best of 2)3
43.94(n)1
34.96(a)1 |
|
III(3862420-3871844)3
1754901 NM_065365.51 NP_497766.31 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G045406MTM16 |
Myotubularin-like phosphatases II-like protein |
23(a)22(a) |
many ↔ manymany ↔ many |
5(1296442-1302444) 3(3292899-3298522) |
rice
(Oryza sativa) |
Liliopsida |
-- |
inositol or phosphatidylinositol phosphatase/ phos... |
23(a) |
1 → many |
8(27856282-27865603) |
ENSEMBL Gene Tree for MTMR4 (if available)
TreeFam Gene Tree for MTMR4 (if available) |
Paralogs
for MTMR4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTMR4 gene
- MTMR72 MTMR122 MTMR22 MTMR102 MTM12 MTMR82 MTMR32 SBF22
- MTMR62 MTMR92 MTMR112 SBF12 MTMR12
9 SIMAP similar genes for MTMR4 using alignment to 7 protein entries: MTMR4_HUMAN (see all proteins):MTMR3 MTMR10 MTMR6 MTM1 MTMR1 MTMR9
MTMR2 MTMR8 WUGSC
MTMR4 for paralogs About GeneDecksing
|
Genomic Variants
for MTMR4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTMR4 (56566893 - 56595266 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MTMR4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTMR4 |
|
Disorders
/ Diseases
for MTMR4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTMR4 for disorders About GeneDecksing
OMIM gene information: 603559
OMIM disorders: --
5  diseases for MTMR4: About MalaCardsmulibrey nanism myopathy thyroiditis prostatitis
neuronitis
Human Genome Epidemiology (HuGE) Navigator: MTMR4 (1 document)
Export disorders for MTMR4 gene to outside databases
|
Publications
for MTMR4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTMR4 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MTMR4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate. (PubMed id 11302699)1, 2 Zhao R.... Zhao Z.J. (2001)
- Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. (PubMed id 9736772)1, 3 Laporte J....Mandel J.-L. (1998)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- MTMR4 attenuates transforming growth factor beta (TGF beta) signaling by dephosphorylating R-Smads in endosomes. (PubMed id 20061380)1, 9 Yu J....Tang H. (2010)
- Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. (PubMed id 19329342)1, 9 Dolley G....Vohl M.C. (2009)
- The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. (PubMed id 19125695)1, 9 Plant P.J....Batt J. (2009)
- Genome-wide association scan for childhood caries impl icates novel genes. (PubMed id 21940522)1 Shaffer J.R....Marazita M.L. (2011)
- The myotubularin phosphatase MTMR4 regulates sorting from early endosomes. (PubMed id 20736309)1 Naughtin M.J....Mitchell C.A. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
|
External Searches for MTMR4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTMR4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTMR4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MTMR4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTMR4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MTMR4 gene:
Search GeneIP for patents involving MTMR4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTMR4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for MTMR4 | | OriGene shRNA RFP for MTMR4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTMR4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTMR4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MTMR4 | | OriGene 3'-UTR Clone for MTMR4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MTMR4 | | OriGene Custom Protein Services for MTMR4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTMR4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTMR4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTMR4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTMR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTMR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTMR4 |
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| | | | Search Tocris compounds for MTMR4 |
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 | | | MTMR4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR4 |
|  |  |  | | | | ThermoFisher Antibodies for MTMR4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR4 |
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