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Aliases for MTMR11 Gene

Aliases for MTMR11 Gene

  • Myotubularin Related Protein 11 2 3 5
  • Cisplatin Resistance-Associated Protein 3 4
  • Cisplatin Resistance Associated 2 3
  • HCRA 3 4
  • CRA 3

External Ids for MTMR11 Gene

Previous GeneCards Identifiers for MTMR11 Gene

  • GC01M146714
  • GC01M148167
  • GC01M149900
  • GC01M121281

Summaries for MTMR11 Gene

GeneCards Summary for MTMR11 Gene

MTMR11 (Myotubularin Related Protein 11) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity. An important paralog of this gene is MTMR2.

UniProtKB/Swiss-Prot for MTMR11 Gene

  • Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR11 Gene

Genomics for MTMR11 Gene

Regulatory Elements for MTMR11 Gene

Promoters for MTMR11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTMR11 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTMR11 Gene

Chromosome:
1
Start:
149,928,650 bp from pter
End:
149,936,898 bp from pter
Size:
8,249 bases
Orientation:
Minus strand

Genomic View for MTMR11 Gene

Genes around MTMR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTMR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTMR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR11 Gene

Proteins for MTMR11 Gene

  • Protein details for MTMR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4FU01-MTMRB_HUMAN
    Recommended name:
    Myotubularin-related protein 11
    Protein Accession:
    A4FU01
    Secondary Accessions:
    • B3KUE4
    • B4DJI6
    • B4DQF5
    • B4E3Q6
    • Q3ZCP7
    • Q5SZ62
    • Q6P2Q8
    • Q99752
    • Q99753

    Protein attributes for MTMR11 Gene

    Size:
    709 amino acids
    Molecular mass:
    79545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB36952.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAB36953.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAH94756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTMR11 Gene

neXtProt entry for MTMR11 Gene

Proteomics data for MTMR11 Gene at MOPED

Post-translational modifications for MTMR11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTMR11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTMR11 Gene

Domains & Families for MTMR11 Gene

Gene Families for MTMR11 Gene

Suggested Antigen Peptide Sequences for MTMR11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4FU01

UniProtKB/Swiss-Prot:

MTMRB_HUMAN :
  • Contains 1 myotubularin phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Domain:
  • Contains 1 myotubularin phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR11: view

Function for MTMR11 Gene

Molecular function for MTMR11 Gene

UniProtKB/Swiss-Prot Function:
Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).
genes like me logo Genes that share phenotypes with MTMR11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MTMR11 Gene

Localization for MTMR11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTMR11 Gene COMPARTMENTS Subcellular localization image for MTMR11 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MTMR11 Gene

Pathways & Interactions for MTMR11 Gene

SuperPathways for MTMR11 Gene

No Data Available

Interacting Proteins for MTMR11 Gene

Gene Ontology (GO) - Biological Process for MTMR11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTMR11 Gene

Drugs & Compounds for MTMR11 Gene

No Compound Related Data Available

Transcripts for MTMR11 Gene

Unigene Clusters for MTMR11 Gene

Myotubularin related protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - -
SP10:
SP11: - - - - - - -
SP12: -
SP13:
SP14: -
SP15:

ExUns: 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15: -

Relevant External Links for MTMR11 Gene

GeneLoc Exon Structure for
MTMR11
ECgene alternative splicing isoforms for
MTMR11

Expression for MTMR11 Gene

mRNA expression in normal human tissues for MTMR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTMR11 Gene

This gene is overexpressed in Colon - Transverse (x8.2).

Protein differential expression in normal tissues from HIPED for MTMR11 Gene

This gene is overexpressed in Testis (25.0), Breast (18.1), and Spinal cord (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTMR11 Gene



SOURCE GeneReport for Unigene cluster for MTMR11 Gene Hs.425144

mRNA Expression by UniProt/SwissProt for MTMR11 Gene

A4FU01-MTMRB_HUMAN
Tissue specificity: Expressed in bone marrow, spleen and thymus.
genes like me logo Genes that share expression patterns with MTMR11: view

Protein tissue co-expression partners for MTMR11 Gene

Primer Products

In Situ Assay Products

Orthologs for MTMR11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTMR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTMR11 36
  • 99 (a)
OneToOne
MTMR11 35
  • 99.67 (n)
  • 99.86 (a)
cow
(Bos Taurus)
Mammalia MTMR11 35
  • 91.49 (n)
  • 91.39 (a)
MTMR11 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTMR11 36
  • 89 (a)
OneToOne
MTMR11 35
  • 90.94 (n)
  • 90.17 (a)
mouse
(Mus musculus)
Mammalia Mtmr11 16
Mtmr11 35
  • 85.74 (n)
  • 87.28 (a)
Mtmr11 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTMR11 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtmr11 35
  • 86.18 (n)
  • 88.58 (a)
chicken
(Gallus gallus)
Aves MTMR11 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTMR11 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr11 35
  • 52.01 (n)
  • 43.5 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882209 35
  • 52.92 (n)
  • 46.29 (a)
mtmr11 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14411 36
  • 23 (a)
OneToMany
Species with no ortholog for MTMR11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTMR11 Gene

ENSEMBL:
Gene Tree for MTMR11 (if available)
TreeFam:
Gene Tree for MTMR11 (if available)

Paralogs for MTMR11 Gene

Paralogs for MTMR11 Gene

genes like me logo Genes that share paralogs with MTMR11: view

Variants for MTMR11 Gene

Sequence variations from dbSNP and Humsavar for MTMR11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11205303 - 149,934,520(+) GGCCA(C/T)GGTCA nc-transcript-variant, reference, missense
rs16836857 - 149,930,420(+) GATTC(G/T)GGAAT nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1868991 -- 149,936,038(+) CCTCA(G/T)GCAGA intron-variant
rs1868992 -- 149,936,215(+) ATCCT(A/G)TTTTC nc-transcript-variant, reference, synonymous-codon, missense, utr-variant-5-prime
rs3738321 -- 149,936,721(-) TCAGC(C/T)TCTCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MTMR11 Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
dgv125e1 CNV Complex 17122850
nsv831537 CNV Loss 17160897

Variation tolerance for MTMR11 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.22; 88.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTMR11 Gene

HapMap Linkage Disequilibrium report
MTMR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTMR11 Gene

Disorders for MTMR11 Gene

Relevant External Links for MTMR11

Genetic Association Database (GAD)
MTMR11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTMR11

No disorders were found for MTMR11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTMR11 Gene

Publications for MTMR11 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48 67
  2. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. (PMID: 12495846) Wishart M.J. … Dixon J.E. (Trends Cell Biol. 2002) 2 3
  3. Genome wide association study identifies a novel putative mammographic density locus at 1q12-q21. (PMID: 25353672) Fernandez-Navarro P. … Pollan M. (Int. J. Cancer 2015) 3
  4. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk R.J. … Jaddoe V.W. (Hum. Mol. Genet. 2015) 3
  5. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3

Products for MTMR11 Gene

Sources for MTMR11 Gene

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