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Aliases for MTMR11 Gene

Aliases for MTMR11 Gene

  • Myotubularin Related Protein 11 2 3 5
  • Cisplatin Resistance-Associated Protein 3 4
  • Cisplatin Resistance Associated 2 3
  • HCRA 3 4
  • Myotubularin-Related Protein 11 3
  • CRA 3

External Ids for MTMR11 Gene

Previous GeneCards Identifiers for MTMR11 Gene

  • GC01M146714
  • GC01M148167
  • GC01M149900
  • GC01M121281

Summaries for MTMR11 Gene

GeneCards Summary for MTMR11 Gene

MTMR11 (Myotubularin Related Protein 11) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity. An important paralog of this gene is MTMR10.

UniProtKB/Swiss-Prot for MTMR11 Gene

  • Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR11 Gene

Genomics for MTMR11 Gene

Regulatory Elements for MTMR11 Gene

Enhancers for MTMR11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G150008 1.8 FANTOM5 ENCODE dbSUPER 18.5 -73.3 -73311 2.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 MTMR11 PRPF3 SETDB1 ADAMTSL4 SV2A UBE2D3P3 CTSK HIST2H2AB BOLA1 HIST2H2BE
GH01G150006 1.5 FANTOM5 ENCODE dbSUPER 18.9 -70.4 -70422 1.7 PKNOX1 NFIB SIN3A ARID4B FEZF1 RAD21 EGR1 FOS EGR2 JUNB MTMR11 SF3B4 OTUD7B SV2A CA14 PIR49087
GH01G150156 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -225.0 -225035 10.3 HDGF FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A ARID4B YBX1 ZNF766 PLEKHO1 SV2A MTMR11 CA14 MCL1 PRPF3 MRPS21 ANP32E RPRD2 TNFAIP8L2
GH01G150213 1.7 FANTOM5 Ensembl ENCODE 10.5 -276.9 -276944 1.5 ATF1 FOXA2 PKNOX1 SIN3A YY1 ELK1 ZNF207 ZHX2 NFYC TBX21 ANP32E RNU2-17P CIART CA14 C1orf54 APH1A PLEKHO1 MTMR11 TARS2 RPRD2
GH01G149985 1.3 Ensembl ENCODE dbSUPER 11.3 -49.9 -49867 2.1 PKNOX1 ZNF133 SIN3A ZNF664 HIC1 ZNF366 ZNF600 PRDM10 KLF8 ZNF263 OTUD7B MTMR11 SF3B4 SV2A HIST2H2AC BOLA1 HIST2H2BE PIR49087
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTMR11 on UCSC Golden Path with GeneCards custom track

Promoters for MTMR11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013446 198 601 PKNOX1 ZSCAN4 SIN3A KLF17 GLIS2 REST ZNF217 ZFP69B ZNF624 ZNF530

Genomic Location for MTMR11 Gene

Chromosome:
1
Start:
149,928,650 bp from pter
End:
149,936,898 bp from pter
Size:
8,249 bases
Orientation:
Minus strand

Genomic View for MTMR11 Gene

Genes around MTMR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTMR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTMR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR11 Gene

Proteins for MTMR11 Gene

  • Protein details for MTMR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4FU01-MTMRB_HUMAN
    Recommended name:
    Myotubularin-related protein 11
    Protein Accession:
    A4FU01
    Secondary Accessions:
    • B3KUE4
    • B4DJI6
    • B4DQF5
    • B4E3Q6
    • Q3ZCP7
    • Q5SZ62
    • Q6P2Q8
    • Q99752
    • Q99753

    Protein attributes for MTMR11 Gene

    Size:
    709 amino acids
    Molecular mass:
    79545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB36952.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAB36953.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAH94756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTMR11 Gene

neXtProt entry for MTMR11 Gene

Post-translational modifications for MTMR11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTMR11 Gene

No data available for DME Specific Peptides for MTMR11 Gene

Domains & Families for MTMR11 Gene

Gene Families for MTMR11 Gene

Suggested Antigen Peptide Sequences for MTMR11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4FU01

UniProtKB/Swiss-Prot:

MTMRB_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR11: view

Function for MTMR11 Gene

Molecular function for MTMR11 Gene

UniProtKB/Swiss-Prot Function:
Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).
genes like me logo Genes that share phenotypes with MTMR11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MTMR11 Gene

Localization for MTMR11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTMR11 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for MTMR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with MTMR11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MTMR11 Gene

Pathways & Interactions for MTMR11 Gene

SuperPathways for MTMR11 Gene

No Data Available

Interacting Proteins for MTMR11 Gene

Gene Ontology (GO) - Biological Process for MTMR11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTMR11 Gene

Drugs & Compounds for MTMR11 Gene

No Compound Related Data Available

Transcripts for MTMR11 Gene

Unigene Clusters for MTMR11 Gene

Myotubularin related protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - -
SP10:
SP11: - - - - - - -
SP12: -
SP13:
SP14: -
SP15:

ExUns: 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15: -

Relevant External Links for MTMR11 Gene

GeneLoc Exon Structure for
MTMR11
ECgene alternative splicing isoforms for
MTMR11

Expression for MTMR11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTMR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTMR11 Gene

This gene is overexpressed in Colon - Transverse (x8.2).

Protein differential expression in normal tissues from HIPED for MTMR11 Gene

This gene is overexpressed in Testis (25.0), Breast (18.1), and Spinal cord (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTMR11 Gene



Protein tissue co-expression partners for MTMR11 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTMR11 Gene:

MTMR11

SOURCE GeneReport for Unigene cluster for MTMR11 Gene:

Hs.425144

mRNA Expression by UniProt/SwissProt for MTMR11 Gene:

A4FU01-MTMRB_HUMAN
Tissue specificity: Expressed in bone marrow, spleen and thymus.

Evidence on tissue expression from TISSUES for MTMR11 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MTMR11: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MTMR11 Gene

Orthologs for MTMR11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTMR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTMR11 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia MTMR11 34 35
  • 91.49 (n)
dog
(Canis familiaris)
Mammalia MTMR11 34 35
  • 90.94 (n)
rat
(Rattus norvegicus)
Mammalia Mtmr11 34
  • 86.18 (n)
mouse
(Mus musculus)
Mammalia Mtmr11 34 16 35
  • 85.74 (n)
oppossum
(Monodelphis domestica)
Mammalia MTMR11 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTMR11 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTMR11 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr11 34
  • 52.01 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882209 34
  • 52.92 (n)
mtmr11 35
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14411 35
  • 23 (a)
OneToMany
Species where no ortholog for MTMR11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTMR11 Gene

ENSEMBL:
Gene Tree for MTMR11 (if available)
TreeFam:
Gene Tree for MTMR11 (if available)

Paralogs for MTMR11 Gene

Paralogs for MTMR11 Gene

genes like me logo Genes that share paralogs with MTMR11: view

Variants for MTMR11 Gene

Sequence variations from dbSNP and Humsavar for MTMR11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000623324 -- 149,929,590(+) GTCCC(G/T)TGTCC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000743503 -- 149,929,236(+) TATTC(C/T)TGGTG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-3-prime
rs1001907372 -- 149,928,480(+) GAACC(A/C/G)TTTCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002256578 -- 149,928,737(+) TATCC(C/G)CCTCA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1002669144 -- 149,933,394(+) TCAAA(C/G)GTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTMR11 Gene

Variant ID Type Subtype PubMed ID
nsv831537 CNV loss 17160897

Variation tolerance for MTMR11 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.22; 88.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTMR11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTMR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTMR11 Gene

Disorders for MTMR11 Gene

Relevant External Links for MTMR11

Genetic Association Database (GAD)
MTMR11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTMR11

No disorders were found for MTMR11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTMR11 Gene

Publications for MTMR11 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  2. A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia and Burkitt lymphoma. (PMID: 17498563) La Starza R. … Mecucci C. (Cancer Genet. Cytogenet. 2007) 4 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. (PMID: 12495846) Wishart M.J. … Dixon J.E. (Trends Cell Biol. 2002) 2 3 64
  5. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk R.J. … Jaddoe V.W. (Hum. Mol. Genet. 2015) 3 64

Products for MTMR11 Gene

Sources for MTMR11 Gene

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