MTMR11 Gene
protein-coding GIFtS: 47
GCID: GC01M149900
|
|
myotubularin related protein 11
| |
Aliases
for MTMR11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myotubularin Related Protein 111 2 | | RP11-212K13.12 | | CRA1 2 | | Cisplatin Resistance Associated2 | | Cisplatin Resistance-Associated Protein2 3 | | Myotubularin-Related Protein 112 | | HCRA1 | | |
Export aliases for MTMR11 gene to outside databasesPrevious GC identifers: GC01M146714 GC01M148167 GC01M121281 |
Summaries
for MTMR11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MTMRB_HUMAN, A4FU01Function: Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPasecatalytic loop which renders it catalytically inactive as a phosphatase (Potential)
|
Genomic Views
for MTMR11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTMR11 gene promoter:
AP-1 SREBP-1c ATF-2 IRF-1 SREBP-1b MEF-2A SREBP-1a c-Jun aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTMR11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTMR11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q12-q21 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q12-q21MTMR11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M149900: view genomic region
(about GC identifiers)
Start:
|
149,900,543 bp from pter |
End:
|
149,908,791 bp from pter |
Size:
|
8,249 bases |
Orientation:
|
minus strand |
|
Proteins
for MTMR11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTMRB_HUMAN, A4FU01 (See
protein sequence)Recommended Name: Myotubularin-related protein 11 Size: 709 amino acids; 79545 Da
Sequence caution: Sequence=AAB36952.1; Type=Frameshift; Positions=8; Sequence=AAB36953.1; Type=Frameshift; Positions=8;Sequence=AAH94756.1; Type=Erroneous initiation;
Secondary accessions: B3KUE4 B4DJI6 B4DQF5 B4E3Q6 Q3ZCP7 Q5SZ62 Q6P2Q8 Q99752 Q99753Alternative splicing: 6 isoforms: A4FU01-1 A4FU01-2 A4FU01-3 A4FU01-4 A4FU01-5 A4FU01-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MTMR11: NX_A4FU01
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A4FU01
MTMR11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001139334.1 NP_870988.2
ENSEMBL proteins: ENSP00000358136 ENSP00000391668 ENSP00000354941 ENSP00000383948
Human Recombinant Protein Products:
MTMR11 Antibody Products:
Assay Products for MTMR11: |
Protein
Domains /
Families
for MTMR11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTMR11 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A4FU01ProtoNet protein and cluster: A4FU01 UniProtKB/Swiss-Prot: MTMRB_HUMAN, A4FU01Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamilySimilarity: Contains 1 myotubularin phosphatase domain |
Function
for MTMR11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MTMRB_HUMAN, A4FU01Function: Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPasecatalytic loop which renders it catalytically inactive as a phosphatase (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MTMR11 (NM_181873) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTMR11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR11 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016791 | phosphatase activity |
IEA | -- |
MTMR11 for ontologies About GeneDecksing
|
Pathways & Interactions
for MTMR11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTMR11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for MTMR11 (A4FU012, 3 ENSP000003581364) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for MTMR11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTMR11
Search CenterWatch for drugs/clinical trials and news about MTMR11 / MTMRB
|
Transcripts
for MTMR11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTMR11 gene (3 alternative transcripts): NM_006697.1 NM_001145862.1 NM_181873.3 Unigene Cluster for MTMR11: Myotubularin related protein 11 Hs.425144 [show with all ESTs]Unigene Representative Sequence: NM_00114586212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000466496 ENST00000482025 ENST00000369140(uc010pbn.1 uc001etm.2)
ENST00000482343 ENST00000492824(uc010pbm.1) ENST00000495054 ENST00000490310
ENST00000493562 ENST00000479272 ENST00000439741(uc001etl.4) ENST00000361405(uc010pbo.1)
ENST00000406732
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTMR11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MTMR11 (NM_181873) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTMR11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR11 |
Additional cDNA sequence: AK097000.1 AK298775.1 AK304691.1 BC032655.1 BC064372.1 BC100818.2 BC100819.2 BC100820.1 BC100821.2 11 DOTS entries: DT.97786519 DT.97840925 DT.95106807 DT.86843673 DT.455891 DT.121325690 DT.95108283 DT.100815612 DT.121325707 DT.121325723 DT.100815610 24/539 AceView cDNA sequences (see all 539): BI857242 BM976279 AI524511 F08178 BC013886 CR605255 BE780544 BE390612 BG674236 BM809480 BQ940959 CR591497 BI906161 BX428757 BM854911 CB130933 CB117198 AV709189 BG741486 BM790123 AW374332 BQ233762 BI861193 CF145128
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MTMR11 (see all 15) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 |
|---|
|
| SP1: | - | | | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP5: | - | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MTMR11
|
Expression
for MTMR11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTMR11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATCAGAGA
About this image
See MTMR11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTMR11
SOURCE GeneReport for Unigene cluster: Hs.425144
UniProtKB/Swiss-Prot: MTMRB_HUMAN, A4FU01Tissue specificity: Expressed in bone marrow, spleen and thymus
SABiosciences Custom PCR Arrays for MTMR11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTMR11
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR11 |
Orthologs
for MTMR11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MTMR11 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CR848792.16 |
-- |
29(a) |
1 ↔ 1 |
16(49065324-49152177) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG144116 |
-- |
19(a) |
1 → many |
X(14726671-14730295) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MTM16AT5G045406 |
Myotubularin-like phosphatases II-like protein |
13(a)13(a) |
many ↔ manymany ↔ many |
3(3292899-3298522) 5(1296442-1302444) |
rice
(Oryza sativa) |
Liliopsida |
-- |
inositol or phosphatidylinositol phosphatase/ phos... |
14(a) |
1 → many |
8(27856282-27865603) |
ENSEMBL Gene Tree for MTMR11 (if available)
TreeFam Gene Tree for MTMR11 (if available) |
Paralogs
for MTMR11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTMR11 gene
- MTMR42 MTMR72 MTMR122 MTMR22 MTMR102 MTM12 MTMR82 MTMR32
- MTMR92 SBF22 MTMR62 SBF12 MTMR12
1 SIMAP similar gene for MTMR11 using alignment to 1 protein entry: MTMRB_HUMAN:MTMR10
MTMR11 for paralogs About GeneDecksing
|
Genomic Variants
for MTMR11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTMR11 (149900543 - 149908791 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MTMR11
2 CNVs: 3313 2326 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTMR11 |
|
Disorders
/ Diseases
for MTMR11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTMR11 for disorders About GeneDecksing
4  diseases for MTMR11: About MalaCardsacute lymphoblastic leukemia lymphoblastic leukemia burkitt's lymphoma leukemia
Export disorders for MTMR11 gene to outside databases
|
Publications
for MTMR11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTMR11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MTMR11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- PTEN and myotubularin phosphatases: from 3-phosphoino sitide dephosphorylation to disease. (PubMed id 12495846)1, 3 Wishart M.J. and Dixon J.E. (2002)
- A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia and Burkitt lymphoma. (PubMed id 17498563)2, 9 La Starza R....Mecucci C. (2007)
- Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1 Gudbjartsson D.F....Stefansson K. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for MTMR11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTMR11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTMR11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTMR11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTMR11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MTMR11 gene:
Search GeneIP for patents involving MTMR11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTMR11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTMR11 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTMR11 |
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