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Aliases for MTMR11 Gene

Aliases for MTMR11 Gene

  • Myotubularin Related Protein 11 2 3
  • Cisplatin Resistance-Associated Protein 3 4
  • Cisplatin Resistance Associated 2 3
  • HCRA 3 4
  • Myotubularin-Related Protein 11 3
  • CRA 3

External Ids for MTMR11 Gene

Previous GeneCards Identifiers for MTMR11 Gene

  • GC01M146714
  • GC01M148167
  • GC01M149900
  • GC01M121281

Summaries for MTMR11 Gene

GeneCards Summary for MTMR11 Gene

MTMR11 (Myotubularin Related Protein 11) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity. An important paralog of this gene is MTMR2.

UniProtKB/Swiss-Prot for MTMR11 Gene

  • Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR11 Gene

Genomics for MTMR11 Gene

Regulatory Elements for MTMR11 Gene

Genomic Location for MTMR11 Gene

Start:
149,928,651 bp from pter
End:
149,936,898 bp from pter
Size:
8,248 bases
Orientation:
Minus strand

Genomic View for MTMR11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTMR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR11 Gene

Proteins for MTMR11 Gene

  • Protein details for MTMR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4FU01-MTMRB_HUMAN
    Recommended name:
    Myotubularin-related protein 11
    Protein Accession:
    A4FU01
    Secondary Accessions:
    • B3KUE4
    • B4DJI6
    • B4DQF5
    • B4E3Q6
    • Q3ZCP7
    • Q5SZ62
    • Q6P2Q8
    • Q99752
    • Q99753

    Protein attributes for MTMR11 Gene

    Size:
    709 amino acids
    Molecular mass:
    79545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB36952.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAB36953.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAH94756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTMR11 Gene

neXtProt entry for MTMR11 Gene

Proteomics data for MTMR11 Gene at MOPED

Post-translational modifications for MTMR11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTMR11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTMR11 Gene

Domains for MTMR11 Gene

Gene Families for MTMR11 Gene

HGNC:
  • DUSPM :Protein tyrosine phosphatases / Class I Cys-based PTPs : Myotubularins

Suggested Antigen Peptide Sequences for MTMR11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4FU01

UniProtKB/Swiss-Prot:

MTMRB_HUMAN :
  • A4FU01
Domain:
  • Contains 1 myotubularin phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR11: view

Function for MTMR11 Gene

Molecular function for MTMR11 Gene

UniProtKB/Swiss-Prot Function: Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).

Gene Ontology (GO) - Molecular Function for MTMR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with MTMR11: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MTMR11 Gene

Localization for MTMR11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTMR11 Gene COMPARTMENTS Subcellular localization image for MTMR11 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MTMR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with MTMR11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MTMR11 Gene

Pathways for MTMR11 Gene

SuperPathways for MTMR11 Gene

No Data Available

Interacting Proteins for MTMR11 Gene

Gene Ontology (GO) - Biological Process for MTMR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation --
genes like me logo Genes that share ontologies with MTMR11: view

No data available for Pathways by source for MTMR11 Gene

Transcripts for MTMR11 Gene

Unigene Clusters for MTMR11 Gene

Myotubularin related protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - -
SP10:
SP11: - - - - - - -
SP12: -
SP13:
SP14: -
SP15:

ExUns: 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15: -

Relevant External Links for MTMR11 Gene

GeneLoc Exon Structure for
MTMR11
ECgene alternative splicing isoforms for
MTMR11

Expression for MTMR11 Gene

mRNA expression in normal human tissues for MTMR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTMR11 Gene

This gene is overexpressed in Colon - Transverse (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MTMR11 Gene

SOURCE GeneReport for Unigene cluster for MTMR11 Gene Hs.425144

mRNA Expression by UniProt/SwissProt for MTMR11 Gene

A4FU01-MTMRB_HUMAN
Tissue specificity: Expressed in bone marrow, spleen and thymus.
genes like me logo Genes that share expressions with MTMR11: view

Orthologs for MTMR11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTMR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTMR11 35
  • 99.67 (n)
  • 99.86 (a)
MTMR11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTMR11 35
  • 91.49 (n)
  • 91.39 (a)
MTMR11 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTMR11 35
  • 90.94 (n)
  • 90.17 (a)
MTMR11 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtmr11 35
  • 85.74 (n)
  • 87.28 (a)
Mtmr11 16
Mtmr11 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTMR11 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtmr11 35
  • 86.18 (n)
  • 88.58 (a)
chicken
(Gallus gallus)
Aves MTMR11 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTMR11 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr11 35
  • 52.01 (n)
  • 43.5 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882209 35
  • 52.92 (n)
  • 46.29 (a)
mtmr11 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14411 36
  • 23 (a)
OneToMany
Species with no ortholog for MTMR11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTMR11 Gene

ENSEMBL:
Gene Tree for MTMR11 (if available)
TreeFam:
Gene Tree for MTMR11 (if available)

Paralogs for MTMR11 Gene

Paralogs for MTMR11 Gene

genes like me logo Genes that share paralogs with MTMR11: view

Variants for MTMR11 Gene

Sequence variations from dbSNP and Humsavar for MTMR11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1868991 -- 149,936,038(+) CCTCA(G/T)GCAGA intron-variant
rs1868992 -- 149,936,215(+) ATCCT(A/G)TTTTC synonymous-codon, reference, utr-variant-5-prime, missense, nc-transcript-variant
rs3214801 -- 149,935,291(+) CCCCC(-/C)AACTT intron-variant
rs3738321 -- 149,936,721(-) TCAGC(C/T)TCTCC utr-variant-5-prime, upstream-variant-2KB, nc-transcript-variant
rs3814010 -- 149,936,965(+) TGAGA(C/T)GGACG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTMR11 Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
dgv125e1 CNV Complex 17122850
nsv831537 CNV Loss 17160897

Relevant External Links for MTMR11 Gene

HapMap Linkage Disequilibrium report
MTMR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTMR11 Gene

Disorders for MTMR11 Gene

Relevant External Links for MTMR11

Genetic Association Database (GAD)
MTMR11
genes like me logo Genes that share disorders with MTMR11: view

No data available for UniProtKB/Swiss-Prot for MTMR11 Gene

Publications for MTMR11 Gene

  1. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. (PMID: 12495846) Wishart M.J. … Dixon J.E. (Trends Cell Biol. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia and Burkitt lymphoma. (PMID: 17498563) La Starza R. … Mecucci C. (Cancer Genet. Cytogenet. 2007) 4 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MTMR11 Gene

Sources for MTMR11 Gene

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