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Aliases for MTMR10 Gene

Aliases for MTMR10 Gene

  • Myotubularin Related Protein 10 2 3

External Ids for MTMR10 Gene

Previous GeneCards Identifiers for MTMR10 Gene

  • GC15M029019
  • GC15M031231
  • GC15M008408

Summaries for MTMR10 Gene

GeneCards Summary for MTMR10 Gene

MTMR10 (Myotubularin Related Protein 10) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity. An important paralog of this gene is MTMR2.

UniProtKB/Swiss-Prot for MTMR10 Gene

  • Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR10 Gene

Genomics for MTMR10 Gene

Regulatory Elements for MTMR10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTMR10 Gene

30,938,941 bp from pter
30,991,607 bp from pter
52,667 bases
Minus strand

Genomic View for MTMR10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTMR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR10 Gene

Proteins for MTMR10 Gene

  • Protein details for MTMR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myotubularin-related protein 10
    Protein Accession:
    Secondary Accessions:
    • Q6P4Q6

    Protein attributes for MTMR10 Gene

    777 amino acids
    Molecular mass:
    88273 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MTMR10 Gene


neXtProt entry for MTMR10 Gene

Proteomics data for MTMR10 Gene at MOPED

Post-translational modifications for MTMR10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTMR10 Gene

No data available for DME Specific Peptides for MTMR10 Gene

Domains for MTMR10 Gene

Gene Families for MTMR10 Gene

  • DUSPM :Protein tyrosine phosphatases / Class I Cys-based PTPs : Myotubularins

Graphical View of Domain Structure for InterPro Entry



  • Q9NXD2
  • Contains 1 myotubularin phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR10: view

Function for MTMR10 Gene

Molecular function for MTMR10 Gene

UniProtKB/Swiss-Prot Function: Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).

Gene Ontology (GO) - Molecular Function for MTMR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with MTMR10: view

Animal Model Products

CRISPR Products

miRNA for MTMR10 Gene

miRTarBase miRNAs that target MTMR10

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTMR10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTMR10 Gene

Localization for MTMR10 Gene

Subcellular locations from

Jensen Localization Image for MTMR10 Gene COMPARTMENTS Subcellular localization image for MTMR10 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MTMR10 Gene

Pathways for MTMR10 Gene

SuperPathways for MTMR10 Gene

No Data Available

Interacting Proteins for MTMR10 Gene

Gene Ontology (GO) - Biological Process for MTMR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation --
genes like me logo Genes that share ontologies with MTMR10: view

No data available for Pathways by source for MTMR10 Gene

Transcripts for MTMR10 Gene

Unigene Clusters for MTMR10 Gene

Myotubularin related protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTMR10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MTMR10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - - -
SP3: -
SP8: - -
SP9: - -

Relevant External Links for MTMR10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTMR10 Gene

mRNA expression in normal human tissues for MTMR10 Gene

mRNA differential expression in normal tissues according to GTEx for MTMR10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTMR10 Gene

SOURCE GeneReport for Unigene cluster for MTMR10 Gene Hs.30141

genes like me logo Genes that share expressions with MTMR10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MTMR10 Gene

Orthologs for MTMR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTMR10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTMR10 35
  • 99.57 (n)
  • 99.74 (a)
MTMR10 36
  • 100 (a)
(Bos Taurus)
Mammalia MTMR10 35
  • 83.51 (n)
  • 89.14 (a)
MTMR10 36
  • 89 (a)
(Canis familiaris)
Mammalia MTMR10 35
  • 88.79 (n)
  • 92.31 (a)
MTMR10 36
  • 93 (a)
(Mus musculus)
Mammalia Mtmr10 35
  • 87.94 (n)
  • 92.61 (a)
Mtmr10 16
Mtmr10 36
  • 93 (a)
(Monodelphis domestica)
Mammalia MTMR10 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia MTMR10 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Mtmr10 35
  • 87.98 (n)
  • 92.87 (a)
(Gallus gallus)
Aves MTMR10 35
  • 78.16 (n)
  • 84.69 (a)
MTMR10 36
  • 84 (a)
(Anolis carolinensis)
Reptilia MTMR10 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr10 35
  • 71.52 (n)
  • 77.17 (a)
(Danio rerio)
Actinopterygii mtmr10 35
  • 63.81 (n)
  • 63.19 (a)
mtmr10 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010275 35
  • 46.09 (n)
  • 35.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14411 35
  • 43.37 (n)
  • 34.6 (a)
CG14411 36
  • 26 (a)
Species with no ortholog for MTMR10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTMR10 Gene

Gene Tree for MTMR10 (if available)
Gene Tree for MTMR10 (if available)

Paralogs for MTMR10 Gene

Paralogs for MTMR10 Gene

Selected SIMAP similar genes for MTMR10 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MTMR10: view

Variants for MTMR10 Gene

Sequence variations from dbSNP and Humsavar for MTMR10 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs872843 -- 30,956,553(+) TCTAG(A/G)CAGAG intron-variant
rs950763 -- 30,956,261(-) TGACA(A/C)ATTAC intron-variant
rs950764 -- 30,955,981(-) GTTTT(G/T)TTTTT intron-variant
rs952543 -- 30,957,076(-) GTGTA(A/G)GGTTT intron-variant
rs1133642 -- 30,974,944(+) ATTTG(A/C/T)TCAAT synonymous-codon, reference, missense, utr-variant-5-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MTMR10 Gene

Variant ID Type Subtype PubMed ID
nsv525795 CNV Gain 19592680
nsv903831 CNV Gain 21882294
nsv832951 CNV Loss 17160897
nsv521842 CNV Gain 19592680
nsv903834 CNV Gain 21882294
esv33507 CNV Loss 17666407
nsv832952 CNV Gain+Loss 17160897
esv2670722 CNV Deletion 23128226
esv273369 CNV Insertion 20981092
esv271889 CNV Insertion 20981092

Relevant External Links for MTMR10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTMR10 Gene

Disorders for MTMR10 Gene

(1) University of Copenhagen DISEASES for MTMR10 Gene

genes like me logo Genes that share disorders with MTMR10: view

No data available for UniProtKB/Swiss-Prot for MTMR10 Gene

Publications for MTMR10 Gene

  1. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. (PMID: 12495846) Wishart M.J. … Dixon J.E. (Trends Cell Biol. 2002) 2 3
  2. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  3. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for MTMR10 Gene

Sources for MTMR10 Gene

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