Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTL5 Gene

Aliases for MTL5 Gene

  • Metallothionein-Like 5, Testis-Specific (Tesmin) 2 3
  • Testis-Specific Metallothionein-Like Protein 3 4
  • CXC Domain Containing 2 2 3
  • Tesmin 3 6
  • Metallothionein-Like 5, Testis-Specific 4
  • CXCDC2 3
  • MTLT 3

External Ids for MTL5 Gene

Previous GeneCards Identifiers for MTL5 Gene

  • GC11M070997
  • GC11M070171
  • GC11M068250
  • GC11M068231
  • GC11M068474
  • GC11M064811

Summaries for MTL5 Gene

Entrez Gene Summary for MTL5 Gene

  • Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTL5 Gene

MTL5 (Metallothionein-Like 5, Testis-Specific (Tesmin)) is a Protein Coding gene. An important paralog of this gene is LIN54.

UniProtKB/Swiss-Prot for MTL5 Gene

  • May have a role in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTL5 Gene

Genomics for MTL5 Gene

Regulatory Elements for MTL5 Gene

Genomic Location for MTL5 Gene

Start:
68,704,796 bp from pter
End:
68,751,564 bp from pter
Size:
46,769 bases
Orientation:
Minus strand

Genomic View for MTL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTL5 Gene

Proteins for MTL5 Gene

  • Protein details for MTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4I5-MTL5_HUMAN
    Recommended name:
    Tesmin
    Protein Accession:
    Q9Y4I5
    Secondary Accessions:
    • A8K8J3
    • Q4G182
    • Q6P2E2
    • Q8NCC8

    Protein attributes for MTL5 Gene

    Size:
    508 amino acids
    Molecular mass:
    55025 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD24668.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for MTL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTL5 Gene

Proteomics data for MTL5 Gene at MOPED

Post-translational modifications for MTL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTL5 Gene

No data available for DME Specific Peptides for MTL5 Gene

Domains for MTL5 Gene

Protein Domains for MTL5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTL5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4I5

UniProtKB/Swiss-Prot:

MTL5_HUMAN :
  • Q9Y4I5
Domain:
  • Contains 1 CRC domain.
Family:
  • Belongs to the lin-54 family.
genes like me logo Genes that share domains with MTL5: view

No data available for Gene Families for MTL5 Gene

Function for MTL5 Gene

Molecular function for MTL5 Gene

GENATLAS Biochemistry: testis specific metallothionein-like protein,tesmin,expressed in spermatocytes,early marker of male germ cell differentiation
UniProtKB/Swiss-Prot Function: May have a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for MTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding NAS 10191092
genes like me logo Genes that share ontologies with MTL5: view

Phenotypes for MTL5 Gene

GenomeRNAi human phenotypes for MTL5:
genes like me logo Genes that share phenotypes with MTL5: view

Animal Model Products

CRISPR Products

miRNA for MTL5 Gene

miRTarBase miRNAs that target MTL5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTL5 Gene

Localization for MTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTL5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTL5 Gene COMPARTMENTS Subcellular localization image for MTL5 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MTL5: view

Pathways for MTL5 Gene

SuperPathways for MTL5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MTL5 Gene

Gene Ontology (GO) - Biological Process for MTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006875 cellular metal ion homeostasis NAS 10191092
GO:0006952 defense response --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis NAS 10191092
GO:0010038 response to metal ion NAS 10191092
genes like me logo Genes that share ontologies with MTL5: view

No data available for Pathways by source for MTL5 Gene

Transcripts for MTL5 Gene

Unigene Clusters for MTL5 Gene

Metallothionein-like 5, testis-specific (tesmin):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTL5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTL5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - - - - - - -
SP6: - -
SP7:

Relevant External Links for MTL5 Gene

GeneLoc Exon Structure for
MTL5
ECgene alternative splicing isoforms for
MTL5

Expression for MTL5 Gene

mRNA expression in normal human tissues for MTL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTL5 Gene

This gene is overexpressed in Testis (21.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MTL5 Gene

SOURCE GeneReport for Unigene cluster for MTL5 Gene Hs.145932

mRNA Expression by UniProt/SwissProt for MTL5 Gene

Q9Y4I5-MTL5_HUMAN
Tissue specificity: Expressed specifically in testis
genes like me logo Genes that share expressions with MTL5: view

In Situ Assay Products

Orthologs for MTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTL5 35
  • 99.21 (n)
  • 98.23 (a)
MTL5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTL5 35
  • 84.48 (n)
  • 80.28 (a)
dog
(Canis familiaris)
Mammalia MTL5 35
  • 83.66 (n)
  • 80.71 (a)
MTL5 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtl5 35
  • 73.35 (n)
  • 68.14 (a)
Mtl5 16
Mtl5 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTL5 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTL5 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtl5 35
  • 72.86 (n)
  • 67.3 (a)
chicken
(Gallus gallus)
Aves MTL5 35
  • 65.4 (n)
  • 54.23 (a)
MTL5 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTL5 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5658 35
zebrafish
(Danio rerio)
Actinopterygii MTL5 36
  • 24 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mip120 36
  • 11 (a)
OneToMany
CG6061 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-54 36
  • 23 (a)
OneToMany
JC8.6a 37
  • 40 (a)
JC8.6b 37
  • 40 (a)
Species with no ortholog for MTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MTL5 Gene

ENSEMBL:
Gene Tree for MTL5 (if available)
TreeFam:
Gene Tree for MTL5 (if available)

Paralogs for MTL5 Gene

Paralogs for MTL5 Gene

Selected SIMAP similar genes for MTL5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTL5: view

Variants for MTL5 Gene

Sequence variations from dbSNP and Humsavar for MTL5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2276267 -- 68,704,998(+) CTGCC(A/G)GGGGC nc-transcript-variant
rs2510365 -- 68,706,406(-) CCCAC(A/T)TTGCA intron-variant
rs2513272 -- 68,706,701(+) TCATT(C/T)TGATT intron-variant
rs2513274 -- 68,727,221(+) ggatc(A/T)cttga intron-variant
rs2513276 -- 68,725,623(+) AAGAC(C/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTL5 Gene

Variant ID Type Subtype PubMed ID
esv2744665 CNV Deletion 23290073
esv2744666 CNV Deletion 23290073
nsv509422 CNV Insertion 20534489

Relevant External Links for MTL5 Gene

HapMap Linkage Disequilibrium report
MTL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTL5 Gene

Disorders for MTL5 Gene

Relevant External Links for MTL5

Genetic Association Database (GAD)
MTL5
genes like me logo Genes that share disorders with MTL5: view

No data available for UniProtKB/Swiss-Prot for MTL5 Gene

Publications for MTL5 Gene

  1. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T. … Mitsui Y. (Genomics 1999) 3 4 23
  2. Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor. (PMID: 9341226) Faller P. … VasA!k M. (Biochemistry 1997) 23
  3. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for MTL5 Gene

Sources for MTL5 Gene

Back to Top

Content