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Aliases for MTL5 Gene

Aliases for MTL5 Gene

  • Metallothionein-Like 5, Testis-Specific (Tesmin) 2 3
  • Testis-Specific Metallothionein-Like Protein 3 4
  • CXC Domain Containing 2 2 3
  • Metallothionein-Like 5, Testis-Specific 4
  • CXCDC2 3
  • TESMIN 3
  • MTLT 3

External Ids for MTL5 Gene

Previous GeneCards Identifiers for MTL5 Gene

  • GC11M070997
  • GC11M070171
  • GC11M068250
  • GC11M068231
  • GC11M068474
  • GC11M064811

Summaries for MTL5 Gene

Entrez Gene Summary for MTL5 Gene

  • Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTL5 Gene

MTL5 (Metallothionein-Like 5, Testis-Specific (Tesmin)) is a Protein Coding gene. An important paralog of this gene is LIN54.

UniProtKB/Swiss-Prot for MTL5 Gene

  • May have a role in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTL5 Gene

Genomics for MTL5 Gene

Regulatory Elements for MTL5 Gene

Genomic Location for MTL5 Gene

68,706,674 bp from pter
68,751,564 bp from pter
44,891 bases
Minus strand

Genomic View for MTL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTL5 Gene

Proteins for MTL5 Gene

  • Protein details for MTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K8J3
    • Q4G182
    • Q6P2E2
    • Q8NCC8

    Protein attributes for MTL5 Gene

    508 amino acids
    Molecular mass:
    55025 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD24668.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for MTL5 Gene


neXtProt entry for MTL5 Gene

Proteomics data for MTL5 Gene at MOPED

Post-translational modifications for MTL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTL5 Gene

No data available for DME Specific Peptides for MTL5 Gene

Domains & Families for MTL5 Gene

Protein Domains for MTL5 Gene


Suggested Antigen Peptide Sequences for MTL5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRC domain.
  • Belongs to the lin-54 family.
  • Contains 1 CRC domain.
  • Belongs to the lin-54 family.
genes like me logo Genes that share domains with MTL5: view

No data available for Gene Families for MTL5 Gene

Function for MTL5 Gene

Molecular function for MTL5 Gene

GENATLAS Biochemistry:
testis specific metallothionein-like protein,tesmin,expressed in spermatocytes,early marker of male germ cell differentiation
UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for MTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding NAS 10191092
genes like me logo Genes that share ontologies with MTL5: view
genes like me logo Genes that share phenotypes with MTL5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MTL5 Gene

Localization for MTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTL5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for MTL5 Gene COMPARTMENTS Subcellular localization image for MTL5 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MTL5: view

Pathways & Interactions for MTL5 Gene

SuperPathways for MTL5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MTL5 Gene

Gene Ontology (GO) - Biological Process for MTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006875 cellular metal ion homeostasis NAS 10191092
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis NAS 10191092
GO:0010038 response to metal ion NAS 10191092
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MTL5: view

No data available for Pathways by source and SIGNOR curated interactions for MTL5 Gene

Drugs & Compounds for MTL5 Gene

No Compound Related Data Available

Transcripts for MTL5 Gene

Unigene Clusters for MTL5 Gene

Metallothionein-like 5, testis-specific (tesmin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTL5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP5: - - - - - - -
SP6: - -

Relevant External Links for MTL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTL5 Gene

mRNA expression in normal human tissues for MTL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTL5 Gene

This gene is overexpressed in Testis (x21.0).

Protein differential expression in normal tissues from HIPED for MTL5 Gene

This gene is overexpressed in Serum (60.9) and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTL5 Gene

SOURCE GeneReport for Unigene cluster for MTL5 Gene Hs.145932

mRNA Expression by UniProt/SwissProt for MTL5 Gene

Tissue specificity: Expressed specifically in testis
genes like me logo Genes that share expression patterns with MTL5: view

Protein tissue co-expression partners for MTL5 Gene

Primer Products

In Situ Assay Products

Orthologs for MTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MTL5 35
  • 84.48 (n)
  • 80.28 (a)
(Canis familiaris)
Mammalia MTL5 35
  • 83.66 (n)
  • 80.71 (a)
MTL5 36
  • 78 (a)
(Mus musculus)
Mammalia Mtl5 35
  • 73.35 (n)
  • 68.14 (a)
Mtl5 16
Mtl5 36
  • 68 (a)
(Pan troglodytes)
Mammalia MTL5 35
  • 99.21 (n)
  • 98.23 (a)
MTL5 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mtl5 35
  • 72.86 (n)
  • 67.3 (a)
(Monodelphis domestica)
Mammalia MTL5 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia MTL5 36
  • 69 (a)
(Gallus gallus)
Aves MTL5 35
  • 65.4 (n)
  • 54.23 (a)
MTL5 36
  • 36 (a)
(Anolis carolinensis)
Reptilia MTL5 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5658 35
(Danio rerio)
Actinopterygii MTL5 36
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6061 37
  • 45 (a)
mip120 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea JC8.6a 37
  • 40 (a)
JC8.6b 37
  • 40 (a)
lin-54 36
  • 23 (a)
Species with no ortholog for MTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MTL5 Gene

Gene Tree for MTL5 (if available)
Gene Tree for MTL5 (if available)

Paralogs for MTL5 Gene

Paralogs for MTL5 Gene

(2) SIMAP similar genes for MTL5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTL5: view

Variants for MTL5 Gene

Sequence variations from dbSNP and Humsavar for MTL5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2510365 -- 68,706,406(-) CCCAC(A/T)TTGCA downstream-variant-500B
rs2513272 -- 68,706,701(+) TCATT(C/T)TGATT utr-variant-3-prime
rs2513274 -- 68,727,221(+) ggatc(A/T)cttga intron-variant
rs2513276 -- 68,725,623(+) AAGAC(C/G)TAAAA intron-variant
rs3018711 -- 68,753,039(+) CACTT(A/G)AAGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTL5 Gene

Variant ID Type Subtype PubMed ID
esv2744665 CNV Deletion 23290073
esv2744666 CNV Deletion 23290073
nsv509422 CNV Insertion 20534489

Variation tolerance for MTL5 Gene

Residual Variation Intolerance Score: 75.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTL5 Gene

Disorders for MTL5 Gene

Relevant External Links for MTL5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MTL5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTL5 Gene

Publications for MTL5 Gene

  1. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T. … Mitsui Y. (Genomics 1999) 23 67
  2. Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor. (PMID: 9341226) Faller P. … VasA!k M. (Biochemistry 1997) 23 67
  3. [Noncoagulative catabolism of fibrinogen]. (PMID: 1091092) Davydov V.S. … Iunosov R.V. (Vopr. Med. Khim. 1975) 2 67
  4. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A. … Wigdahl B. (J. Neurovirol. 2013) 67
  5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 67

Products for MTL5 Gene

Sources for MTL5 Gene

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