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MTL5 Gene

protein-coding   GIFtS: 50
GCID: GC11M068474

Metallothionein-Like 5, Testis-Specific (Tesmin)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metallothionein-Like 5, Testis-Specific (Tesmin)1 2     CXCDC22
CXC Domain Containing 21 2     MTLT2
Testis-Specific Metallothionein-Like Protein2 3     tesmin2
TESMIN2 5     Metallothionein-Like 5, Testis-Specific3

External Ids:    HGNC: 74461   Entrez Gene: 96332   Ensembl: ENSG000001327497   OMIM: 6043745   UniProtKB: Q9Y4I53   

Export aliases for MTL5 gene to outside databases

Previous GC identifers: GC11M070997 GC11M070171 GC11M068724 GC11M068250 GC11M068231 GC11M064811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTL5 Gene:
Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and
bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell
growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein
which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MTL5 Gene:
MTL5 (metallothionein-like 5, testis-specific (tesmin)) is a protein-coding gene. Diseases associated with MTL5 include neuronitis. An important paralog of this gene is LIN54.

UniProtKB/Swiss-Prot: MTL5_HUMAN, Q9Y4I5
Function: May have a role in spermatogenesis (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTL5 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   Pax-2   Pax-2a   E2F-2   NF-kappaB   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MTL5 promoter sequence
   Search Chromatin IP Primers for MTL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2-q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.2-q13.3

MTL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTL5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M068474:  view genomic region     (about GC identifiers)

Start:
68,474,908 bp from pter      End:
68,519,032 bp from pter
Size:
44,125 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MTL5_HUMAN, Q9Y4I5 (See protein sequence)
Recommended Name: Tesmin  
Size: 508 amino acids; 55025 Da
Sequence caution: Sequence=AAD24668.1; Type=Frameshift; Positions=Several;
Secondary accessions: A8K8J3 Q4G182 Q6P2E2 Q8NCC8
Alternative splicing: 3 isoforms:  Q9Y4I5-1   Q9Y4I5-2   Q9Y4I5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTL5: NX_Q9Y4I5

Explore proteomics data for MTL5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034745.1  NP_004914.2  

    ENSEMBL proteins: 
     ENSP00000255087   ENSP00000454311   ENSP00000403086   ENSP00000440968  

    MTL5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MTL5
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    Novus Biologicals MTL5 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MTL5

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    ThermoFisher Antibodies for MTL5
    LSBio Antibodies in human, mouse, rat for MTL5

    MTL5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MTL5
    Cloud-Clone Corp. CLIAs for MTL5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR005172 CRC
     IPR028307 LIN54/Tesmin

    Graphical View of Domain Structure for InterPro Entry Q9Y4I5

    ProtoNet protein and cluster: Q9Y4I5

    UniProtKB/Swiss-Prot: MTL5_HUMAN, Q9Y4I5
    Similarity: Belongs to the lin-54 family
    Similarity: Contains 1 CRC domain


    MTL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTL5_HUMAN, Q9Y4I5
    Function: May have a role in spermatogenesis (Probable)

         Genatlas biochemistry entry for MTL5:
    testis specific metallothionein-like protein,tesmin,expressed in spermatocytes,early marker of male germ cell
    differentiation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding NAS10191092
         
    MTL5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MTL5:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTL5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTL5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTL5

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTL5:
    hsa-mir-378a-5p (MIRT043976)

    Block miRNA regulation of human, mouse, rat MTL5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTL5 (see all 10):
    hsa-miR-1261 hsa-miR-519c-3p hsa-miR-519a hsa-miR-548l hsa-miR-3692 hsa-miR-519b-3p hsa-miR-221* hsa-miR-370
    SwitchGear 3'UTR luciferase reporter plasmidMTL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTL5
    Predesigned siRNA for gene silencing in human, mouse, rat MTL5

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for MTL5
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    GenScript: all cDNA clones in your preferred vector (see all 2): MTL5 (NM_004923)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTL5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MTL5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTL5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTL5_HUMAN, Q9Y4I5: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    MTL5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTL5: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MTL5

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MTL5 (ENSP000002550874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX3ENSP000003366874STRING: ENSP00000336687
    CBX1ENSP000002256034STRING: ENSP00000225603
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006875cellular metal ion homeostasis NAS10191092
    GO:0006952defense response ----
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis NAS10191092
    GO:0010038response to metal ion NAS10191092

    MTL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTL5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTL5 gene (2 alternative transcripts): 
    NM_001039656.1  NM_004923.3  

    Unigene Cluster for MTL5:

    Metallothionein-like 5, testis-specific (tesmin)
    Hs.145932  [show with all ESTs]
    Unigene Representative Sequence: AK128308
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255087(uc001ooc.3) ENST00000544398 ENST00000543240 ENST00000540869
    ENST00000443940(uc001ood.1 uc009ysi.1) ENST00000438124 ENST00000544963(uc001ooe.3)
    ENST00000538944 ENST00000432435
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTL5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTL5 (see all 10):
    hsa-miR-1261 hsa-miR-519c-3p hsa-miR-519a hsa-miR-548l hsa-miR-3692 hsa-miR-519b-3p hsa-miR-221* hsa-miR-370
    SwitchGear 3'UTR luciferase reporter plasmidMTL5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTL5
    Predesigned siRNA for gene silencing in human, mouse, rat MTL5
    Clone
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    OriGene clones in human, mouse for MTL5 (see all 12)
    OriGene ORF clones in mouse, rat for MTL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MTL5 (NM_004923)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTL5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MTL5
    OriGene qSTAR qPCR primer pairs in human, mouse for MTL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTL5
      QuantiTect SYBR Green Assays in human, mouse, rat MTL5
      QuantiFast Probe-based Assays in human, mouse, rat MTL5

    Additional mRNA sequence: 

    AK074817.1 AK128308.1 AK292358.1 BC027593.1 BC054047.2 BC064579.1 BC070301.1 

    5 DOTS entries:

    DT.307514  DT.99936432  DT.100726079  DT.100776566  DT.92419246 

    Selected AceView cDNA sequences (see all 80):

    BX476847 BC064579 CK821086 AI652317 AI914451 AI271740 BC054047 BM790577 
    AI968123 AA975648 NM_004923 BI711510 AI874249 BI793224 BU153626 AW293246 
    CD557485 AI275776 BE467611 AI968415 BE501038 AI624835 BE220085 BQ225377 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTL5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                            -                 -           -     -     -     -     -                                       
    SP2:                                            -                 -                                                                           
    SP3:                                            -           -     -                                                                           
    SP4:                                                                                                                                          
    SP5:                                            -     -     -     -           -     -     -                                                   


    ECgene alternative splicing isoforms for MTL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCACATAA
    MTL5 Expression
    About this image


    MTL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
    MTL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.145932

    UniProtKB/Swiss-Prot: MTL5_HUMAN, Q9Y4I5
    Tissue specificity: Expressed specifically in testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTL5: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MTL5
    OriGene qSTAR qPCR primer pairs in human, mouse for MTL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTL5
    QuantiTect SYBR Green Assays in human, mouse, rat MTL5
    QuantiFast Probe-based Assays in human, mouse, rat MTL5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTL5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtl51 , 5 metallothionein-like 5, testis-specific (tesmin)1, 5 73.35(n)1
    68.14(a)1
      19 (3.15 cM)5
    177711  NM_001039657.21  NP_001034746.11 
     33888575 
    chicken
    (Gallus gallus)
    Aves MTL51 metallothionein-like 5, testis-specific (tesmin) 65.4(n)
    54.23(a)
      768517  XM_001231492.3  XP_001231493.2 
    lizard
    (Anolis carolinensis)
    Reptilia MTL56
    metallothionein-like 5, testis-specific (tesmin)
    61(a)
    1 ↔ 1
    1(75853419-75866695)
    zebrafish
    (Danio rerio)
    Actinopterygii MTL56
    metallothionein-like 5, testis-specific (tesmin)
    24(a)
    1 ↔ 1
    25(10725352-10754825) ENSDARG00000097662
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60613   -- 45(a)   50A14   --
    worm
    (Caenorhabditis elegans)
    Secernentea JC8.6a3   -- 40(a)
    (best of 2)
      IV(13241237-13243328)   --


    ENSEMBL Gene Tree for MTL5 (if available)
    TreeFam Gene Tree for MTL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTL5 gene
    LIN542  
    2 SIMAP similar genes for MTL5 using alignment to 3 protein entries:     MTL5_HUMAN (see all proteins):
    DKFZp686L18142    LIN54

    MTL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTL5 (see all 906)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831968611,2
    --68474444(+) CAGTGC/TGCCTC 1 -- ds50010--------
    rs71209661,2
    C,H--68474456(+) CTGTTC/TGCCGC 1 -- ds50016Minor allele frequency- T:0.00NS EA NA 422
    rs1160492331,2
    F--68474486(+) GCACAC/TACAGC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs770612871,2
    C,F--68474737(+) GGCCCG/AGCAGC 1 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1875628361,2
    --68474960(+) AAAAGC/GGTCAA 1 -- ut310--------
    rs1468127861,2
    C--68474961(+) AAAGCA/GTCAAC 1 -- ut310--------
    rs1931568101,2
    C--68474980(+) TCATTG/TTACCT 1 -- ut310--------
    rs1410456241,2
    C--68474984(+) TTTACC/TTGCTG 1 -- ut310--------
    rs1431197951,2
    C--68475001(+) ACAAGC/TTAGTT 1 -- ut310--------
    rs1147045651,2
    C,F--68475167(+) CCTGCG/AAGGCC 1 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for MTL5 (68474908 - 68519032 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MTL5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744665CNV Deletion23290073
    esv2744666CNV Deletion23290073
    nsv509422CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTL5
    DNA2.0 Custom Variant and Variant Library Synthesis for MTL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604374    OMIM disorders: --

    1 disease for MTL5:    
    About MalaCards
    neuronitis


    MTL5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTL5

    Export disorders for MTL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTL5 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with MTL5)
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    1. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PubMed id 10191092)1, 2, 9 Sugihara T.... Mitsui Y. (Genomics 1999)
    2. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    3. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Tesmin transcription is regulated differently during male and female meiosis. (PubMed id 14648882)1 Olesen C....Byskov A.G. (Mol. Reprod. Dev. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice. (PubMed id 12606435)1 Sutou S....Mitsui Y. (Biol. Reprod. 2003)
    8. Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes. (PubMed id 11803038)1 Matsuura T....Mitsui Y. (J. Inorg. Biochem. 2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. [Noncoagulative catabolism of fibrinogen]. (PubMed id 1091092)3 Davydov V.S....Iunosov R.V. (Vopr. Med. Khim. 1975)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9633 HGNC: 7446 AceView: MTL5 Ensembl:ENSG00000132749 euGenes: HUgn9633
    ECgene: MTL5 H-InvDB: MTL5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTL5 gene:
    Search GeneIP for patents involving MTL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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