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Aliases for MTIF3 Gene

Aliases for MTIF3 Gene

  • Mitochondrial Translational Initiation Factor 3 2 3 5
  • IF-3(Mt) 3 4
  • IF3mt 3 4
  • Translation Initiation Factor IF-3, Mitochondrial 3
  • IF3(Mt) 4
  • IF-3Mt 4

External Ids for MTIF3 Gene

Previous GeneCards Identifiers for MTIF3 Gene

  • GC13M025989
  • GC13M021988
  • GC13M026938
  • GC13M025807
  • GC13M026907
  • GC13M028009
  • GC13M008831

Summaries for MTIF3 Gene

Entrez Gene Summary for MTIF3 Gene

  • This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]

GeneCards Summary for MTIF3 Gene

MTIF3 (Mitochondrial Translational Initiation Factor 3) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include translation initiation factor activity and ribosomal small subunit binding.

UniProtKB/Swiss-Prot for MTIF3 Gene

  • IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.

Additional gene information for MTIF3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTIF3 Gene

Genomics for MTIF3 Gene

Regulatory Elements for MTIF3 Gene

Enhancers for MTIF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H027444 1.6 Ensembl ENCODE dbSUPER 23.9 +2.6 2552 7 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3 MTIF3 GTF3A PIR36871 GC13M027437
GH13H027423 1.3 ENCODE dbSUPER 19.5 +24.2 24159 5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 MTIF3 GTF3A GC13M027437
GH13H027440 1 Ensembl ENCODE dbSUPER 22.2 +8.9 8889 3 CTBP1 PKNOX1 POLR2A ZBTB33 MTIF3 RNU6-63P GTF3A GC13M027437 PIR36871
GH13H027455 1.1 Ensembl ENCODE dbSUPER 16.8 -4.9 -4938 1 IRF2 L3MBTL2 NR2F1 ZBTB40 CTBP1 CEBPA IKZF2 NR2C2 MTIF3 GTF3A RNU6-63P GC13P027459
GH13H027402 1.1 Ensembl ENCODE 15.4 +46.1 46062 4 PKNOX1 FOXA2 FEZF1 DMAP1 ZNF2 RAD21 YY1 SCRT2 ZNF143 RUNX3 MTIF3 RNU6-63P GC13M027403 RNY1P1 GTF3A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTIF3 on UCSC Golden Path with GeneCards custom track

Promoters for MTIF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060341 354 2201 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3

Genomic Location for MTIF3 Gene

Chromosome:
13
Start:
27,435,639 bp from pter
End:
27,450,854 bp from pter
Size:
15,216 bases
Orientation:
Minus strand

Genomic View for MTIF3 Gene

Genes around MTIF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTIF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTIF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTIF3 Gene

Proteins for MTIF3 Gene

  • Protein details for MTIF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2K0-IF3M_HUMAN
    Recommended name:
    Translation initiation factor IF-3, mitochondrial
    Protein Accession:
    Q9H2K0
    Secondary Accessions:
    • Q05BL8
    • Q5W0V0
    • Q86X68

    Protein attributes for MTIF3 Gene

    Size:
    278 amino acids
    Molecular mass:
    31725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39599.1; Type=Frameshift; Positions=246; Evidence={ECO:0000305};

neXtProt entry for MTIF3 Gene

Post-translational modifications for MTIF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTIF3 Gene

Domains & Families for MTIF3 Gene

Gene Families for MTIF3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MTIF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2K0

UniProtKB/Swiss-Prot:

IF3M_HUMAN :
  • Belongs to the IF-3 family.
Family:
  • Belongs to the IF-3 family.
genes like me logo Genes that share domains with MTIF3: view

Function for MTIF3 Gene

Molecular function for MTIF3 Gene

UniProtKB/Swiss-Prot Function:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.

Phenotypes From GWAS Catalog for MTIF3 Gene

Gene Ontology (GO) - Molecular Function for MTIF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008135 translation factor activity, RNA binding IDA 12095986
GO:0043022 ribosome binding IBA --
GO:0043024 ribosomal small subunit binding IDA 12095986
genes like me logo Genes that share ontologies with MTIF3: view

Phenotypes for MTIF3 Gene

genes like me logo Genes that share phenotypes with MTIF3: view

Animal Model Products

CRISPR Products

miRNA for MTIF3 Gene

miRTarBase miRNAs that target MTIF3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTIF3 Gene

Localization for MTIF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTIF3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTIF3 gene
Compartment Confidence
mitochondrion 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTIF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IC 12095986
genes like me logo Genes that share ontologies with MTIF3: view

Pathways & Interactions for MTIF3 Gene

genes like me logo Genes that share pathways with MTIF3: view

Pathways by source for MTIF3 Gene

Gene Ontology (GO) - Biological Process for MTIF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0032790 ribosome disassembly IDA 12095986
GO:0070124 mitochondrial translational initiation IDA 12095986
genes like me logo Genes that share ontologies with MTIF3: view

No data available for SIGNOR curated interactions for MTIF3 Gene

Drugs & Compounds for MTIF3 Gene

No Compound Related Data Available

Transcripts for MTIF3 Gene

Unigene Clusters for MTIF3 Gene

Mitochondrial translational initiation factor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTIF3 Gene

No ASD Table

Relevant External Links for MTIF3 Gene

GeneLoc Exon Structure for
MTIF3
ECgene alternative splicing isoforms for
MTIF3

Expression for MTIF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTIF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTIF3 Gene

This gene is overexpressed in Salivary gland (13.9), Testis (9.6), Heart (9.3), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTIF3 Gene



Protein tissue co-expression partners for MTIF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTIF3 Gene:

MTIF3

SOURCE GeneReport for Unigene cluster for MTIF3 Gene:

Hs.534582

Evidence on tissue expression from TISSUES for MTIF3 Gene

  • Spleen(4.4)
  • Blood(4.3)
  • Intestine(4.3)
  • Lymph node(4.3)
  • Skin(4.3)
  • Heart(2.3)
  • Kidney(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MTIF3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTIF3 Gene

Orthologs for MTIF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTIF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTIF3 33 34
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia MTIF3 33 34
  • 76.41 (n)
cow
(Bos Taurus)
Mammalia MTIF3 33 34
  • 74.88 (n)
mouse
(Mus musculus)
Mammalia Mtif3 33 16 34
  • 72.65 (n)
rat
(Rattus norvegicus)
Mammalia Mtif3 33
  • 71.67 (n)
oppossum
(Monodelphis domestica)
Mammalia MTIF3 34
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTIF3 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTIF3 33 34
  • 55.51 (n)
lizard
(Anolis carolinensis)
Reptilia MTIF3 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtif3 33
  • 54.15 (n)
zebrafish
(Danio rerio)
Actinopterygii mtif3 33 34
  • 52.62 (n)
Species where no ortholog for MTIF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTIF3 Gene

ENSEMBL:
Gene Tree for MTIF3 (if available)
TreeFam:
Gene Tree for MTIF3 (if available)

Paralogs for MTIF3 Gene

Pseudogenes.org Pseudogenes for MTIF3 Gene

genes like me logo Genes that share paralogs with MTIF3: view

No data available for Paralogs for MTIF3 Gene

Variants for MTIF3 Gene

Sequence variations from dbSNP and Humsavar for MTIF3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000056002 -- 27,447,810(+) TTTCG(A/C)GATTC intron-variant
rs1000208911 -- 27,442,115(+) TTGAG(A/G)ATTAA intron-variant
rs1000284566 -- 27,452,378(+) TTGTT(C/T)TGTTT upstream-variant-2KB
rs1000311151 -- 27,436,687(+) TGTTA(A/G)CATCA intron-variant
rs1000348610 -- 27,451,739(+) CATAT(C/T)TCAAG upstream-variant-2KB

Variation tolerance for MTIF3 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTIF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTIF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTIF3 Gene

Disorders for MTIF3 Gene

Relevant External Links for MTIF3

Genetic Association Database (GAD)
MTIF3
Human Genome Epidemiology (HuGE) Navigator
MTIF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTIF3

No disorders were found for MTIF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTIF3 Gene

Publications for MTIF3 Gene

  1. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. (PMID: 12095986) Koc EC … Spremulli LL (The Journal of biological chemistry 2002) 2 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 45 60
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  5. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PMID: 19209188) Reiling E … Dekker JM (European journal of human genetics : EJHG 2009) 3 45 60

Products for MTIF3 Gene

  • Addgene plasmids for MTIF3

Sources for MTIF3 Gene

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