MTIF3 Gene
protein-coding GIFtS: 43
GCID: GC13M028009
|
|
mitochondrial translational initiation factor 3
| |
Aliases
for MTIF3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Translational Initiation Factor 31 2 | | IF-3mt1 | | IF3(Mt)1 | | Translation Initiation Factor IF-3, Mitochondrial2 | | IF-3(Mt)2 3 | | IF-3Mt3 | | IF3mt2 3 | | |
Export aliases for MTIF3 gene to outside databasesPrevious GC identifers: GC13M025989 GC13M021988 GC13M026938 GC13M025807 GC13M026907 GC13M008831 |
Summaries
for MTIF3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MTIF3:
This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism inthis gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcriptvariants. A pseudogene of this gene is found on chromosome 5. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: IF3M_HUMAN, Q9H2K0Function: IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28Ssubunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesisinitiation begins
|
Genomic Views
for MTIF3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MTIF3
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTIF3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTIF3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.2 Ensembl cytogenetic band: 13q12.2 HGNC cytogenetic band: 13q12.2MTIF3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M028009: view genomic region
(about GC identifiers)
Start:
|
28,009,776 bp from pter |
End:
|
28,024,739 bp from pter |
Size:
|
14,964 bases |
Orientation:
|
minus strand |
|
Proteins
for MTIF3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IF3M_HUMAN, Q9H2K0 (See
protein sequence)Recommended Name: Translation initiation factor IF-3, mitochondrial precursor Size: 278 amino acids; 31725 Da
Subcellular location: Mitochondrion (Probable)
Sequence caution: Sequence=AAH39599.1; Type=Frameshift; Positions=246;
Secondary accessions: Q05BL8 Q5W0V0 Q86X68Explore the universe of human proteins at neXtProt for MTIF3: NX_Q9H2K0
MTIF3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001159733.1 NP_001159734.1 NP_001159735.1 NP_690876.3
ENSEMBL proteins: ENSP00000370508 ENSP00000370512 ENSP00000400084 ENSP00000384659
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
MTIF3 for ontologies About GeneDecksing
MTIF3 Antibody Products:
Assay Products for MTIF3: |
Protein
Domains /
Families
for MTIF3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTIF3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H2K0ProtoNet protein and cluster: Q9H2K0 1 Blocks protein family: IPB001288 Initiation factor 3
UniProtKB/Swiss-Prot: IF3M_HUMAN, Q9H2K0Similarity: Belongs to the IF-3 family |
Function
for MTIF3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IF3M_HUMAN, Q9H2K0Function: IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28Ssubunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesisinitiation begins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTIF3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTIF3 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): MTIF3 (NM_152912) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTIF3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTIF3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTIF3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MTIF3 for ontologies About GeneDecksing
|
Pathways & Interactions
for MTIF3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTIF3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for MTIF3 (ENSP000003705084) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MTIF3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTIF3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTIF3
Search CenterWatch for drugs/clinical trials and news about MTIF3 / IF3M
|
Transcripts
for MTIF3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTIF3 gene (4 alternative transcripts): NM_001166261.1 NM_001166262.1 NM_001166263.1 NM_152912.4 Unigene Cluster for MTIF3: Mitochondrial translational initiation factor 3 Hs.534582 [show with all ESTs]Unigene Representative Sequence: AL83272813 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381116(uc001urk.3) ENST00000381120 ENST00000461838 ENST00000460973
ENST00000471771 ENST00000493719 ENST00000485650 ENST00000484342 ENST00000485959
ENST00000483903 ENST00000464753 ENST00000431572(uc001urh.3 uc021rhm.1 uc001urj.3)
ENST00000405591(uc021rhl.1 uc001uri.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTIF3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTIF3 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): MTIF3 (NM_152912) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTIF3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTIF3 |
Additional cDNA sequence: AF410851.1 AK090995.1 AK094420.1 AL832728.1 BC039599.1 BC046166.1 17 DOTS entries: DT.100820160 DT.87017152 DT.87008500 DT.100664844 DT.100765244 DT.101984289 DT.100678717 DT.95235904 DT.100739738 DT.100820167 DT.120769633 DT.75156476 DT.97855947 DT.100038816 DT.100671109 DT.100773125 DT.120769649 24/205 AceView cDNA sequences (see all 205): N45430 AA203546 AI393761 BM768315 AA258717 N35287 BM698996 BG541999 AI458229 CF128114 BM768550 BM852666 AA460093 BU172951 AA236892 AA704439 AI288042 AW139820 BM547732 AI242056 AA235676 BM856438 BE504208 BM985154
GeneLoc Exon Structure
|
Expression
for MTIF3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTIF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGAGAGA
About this image
See MTIF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTIF3
SOURCE GeneReport for Unigene cluster: Hs.534582
SABiosciences Custom PCR Arrays for MTIF3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTIF3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTIF3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTIF3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTIF3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTIF3 |
Orthologs
for MTIF3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MTIF3 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for MTIF3 (if available)
TreeFam Gene Tree for MTIF3 (if available) |
Paralogs
for MTIF3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTIF3 gene
MTIF3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MTIF3
PGOHUM00000235105
|
Genomic Variants
for MTIF3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTIF3 (28009776 - 28024739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MTIF3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTIF3 |
|
Disorders
/ Diseases
for MTIF3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTIF3 for disorders About GeneDecksing
2  diseases for MTIF3: About MalaCardsparkinson's disease diabetes mellitus
Human Genome Epidemiology (HuGE) Navigator: MTIF3 (6 documents)
Export disorders for MTIF3 gene to outside databases
|
Publications
for MTIF3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTIF3 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with MTIF3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. (PubMed id 12095986)1, 2, 3 Koc E.C. and Spremulli L.L. (2002)
- The interaction of mammalian mitochondrial translational initiation factor 3 with ribosomes: evolution of terminal extensions in IF3mt. (PubMed id 18056078)1, 9 Haque M.E....Spremulli L.L. (2008)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
- Mitochondrial translation initiation factor 3 polymor phism and Parkinson's disease. (PubMed id 20887776)1 Behrouz B....Farrer M.J. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Possible involvement of a mitochondrial translation i nitiation factor 3 variant causing decreased mRNA levels in Parkinson's disease . (PubMed id 20976088)1 Anvret A....Belin A.C. (2010)
- Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)1 Reiling E....Dekker J.M. (2009)
- Evidence for an active role of IF3mt in the initiatio n of translation in mammalian mitochondria. (PubMed id 19239245)1 Christian B.E. and Spremulli L.L. (2009)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
|
External Searches for MTIF3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTIF3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTIF3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTIF3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTIF3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MTIF3 gene:
Search GeneIP for patents involving MTIF3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTIF3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MTIF3 | | OriGene shRNA RFP for MTIF3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTIF3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTIF3 | | | OriGene Protein Over-expression Lysate for MTIF3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTIF3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTIF3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MTIF3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MTIF3 | | OriGene Custom Protein Services for MTIF3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTIF3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTIF3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTIF3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTIF3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTIF3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTIF3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MTIF3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MTIF3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTIF3 |
|  |  |  | | | | ThermoFisher Antibody for MTIF3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTIF3 |
|
|
|
|
