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Aliases for MTIF3 Gene

Aliases for MTIF3 Gene

  • Mitochondrial Translational Initiation Factor 3 2 3
  • IF-3(Mt) 3 4
  • IF3mt 3 4
  • IF3(Mt) 4
  • IF-3Mt 4

External Ids for MTIF3 Gene

Previous GeneCards Identifiers for MTIF3 Gene

  • GC13M025989
  • GC13M021988
  • GC13M026938
  • GC13M025807
  • GC13M026907
  • GC13M028009
  • GC13M008831

Summaries for MTIF3 Gene

Entrez Gene Summary for MTIF3 Gene

  • This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]

GeneCards Summary for MTIF3 Gene

MTIF3 (Mitochondrial Translational Initiation Factor 3) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include translation initiation factor activity and ribosomal small subunit binding.

UniProtKB/Swiss-Prot for MTIF3 Gene

  • IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTIF3 Gene

Genomics for MTIF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTIF3 Gene

Chromosome:
13
Start:
27,435,639 bp from pter
End:
27,450,854 bp from pter
Size:
15,216 bases
Orientation:
Minus strand

Genomic View for MTIF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTIF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTIF3 Gene

No data available for Regulatory Elements for MTIF3 Gene

Proteins for MTIF3 Gene

  • Protein details for MTIF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2K0-IF3M_HUMAN
    Recommended name:
    Translation initiation factor IF-3, mitochondrial
    Protein Accession:
    Q9H2K0
    Secondary Accessions:
    • Q05BL8
    • Q5W0V0
    • Q86X68

    Protein attributes for MTIF3 Gene

    Size:
    278 amino acids
    Molecular mass:
    31725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39599.1; Type=Frameshift; Positions=246; Evidence={ECO:0000305};

neXtProt entry for MTIF3 Gene

Proteomics data for MTIF3 Gene at MOPED

Post-translational modifications for MTIF3 Gene

No Post-translational modifications

Other Protein References for MTIF3 Gene

Antibody Products

No data available for DME Specific Peptides for MTIF3 Gene

Domains & Families for MTIF3 Gene

Suggested Antigen Peptide Sequences for MTIF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2K0

UniProtKB/Swiss-Prot:

IF3M_HUMAN :
  • Belongs to the IF-3 family.
Family:
  • Belongs to the IF-3 family.
genes like me logo Genes that share domains with MTIF3: view

No data available for Gene Families for MTIF3 Gene

Function for MTIF3 Gene

Molecular function for MTIF3 Gene

UniProtKB/Swiss-Prot Function:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.

Gene Ontology (GO) - Molecular Function for MTIF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008135 translation factor activity, RNA binding IDA 12095986
GO:0043024 ribosomal small subunit binding IDA 12095986
genes like me logo Genes that share ontologies with MTIF3: view

Phenotypes for MTIF3 Gene

GenomeRNAi human phenotypes for MTIF3:
genes like me logo Genes that share phenotypes with MTIF3: view

Animal Model Products

CRISPR Products

miRNA for MTIF3 Gene

miRTarBase miRNAs that target MTIF3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTIF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MTIF3 Gene

Localization for MTIF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTIF3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTIF3 Gene COMPARTMENTS Subcellular localization image for MTIF3 gene
Compartment Confidence
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MTIF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IC 12095986
genes like me logo Genes that share ontologies with MTIF3: view

Pathways & Interactions for MTIF3 Gene

genes like me logo Genes that share pathways with MTIF3: view

Pathways by source for MTIF3 Gene

Gene Ontology (GO) - Biological Process for MTIF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0032790 ribosome disassembly IDA 12095986
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MTIF3: view

No data available for SIGNOR curated interactions for MTIF3 Gene

Drugs & Compounds for MTIF3 Gene

No Compound Related Data Available

Transcripts for MTIF3 Gene

Unigene Clusters for MTIF3 Gene

Mitochondrial translational initiation factor 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTIF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTIF3 Gene

No ASD Table

Relevant External Links for MTIF3 Gene

GeneLoc Exon Structure for
MTIF3
ECgene alternative splicing isoforms for
MTIF3

Expression for MTIF3 Gene

mRNA expression in normal human tissues for MTIF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTIF3 Gene

This gene is overexpressed in Salivary gland (13.9), Testis (9.6), Heart (9.3), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTIF3 Gene



SOURCE GeneReport for Unigene cluster for MTIF3 Gene Hs.534582

genes like me logo Genes that share expression patterns with MTIF3: view

Protein tissue co-expression partners for MTIF3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTIF3 Gene

Orthologs for MTIF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTIF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTIF3 35
  • 74.88 (n)
  • 69.12 (a)
MTIF3 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTIF3 35
  • 76.41 (n)
  • 67.51 (a)
MTIF3 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtif3 35
  • 72.65 (n)
  • 65.93 (a)
Mtif3 16
Mtif3 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTIF3 35
  • 99.88 (n)
  • 99.64 (a)
MTIF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtif3 35
  • 71.67 (n)
  • 64.47 (a)
oppossum
(Monodelphis domestica)
Mammalia MTIF3 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTIF3 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTIF3 35
  • 55.51 (n)
  • 39.47 (a)
MTIF3 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTIF3 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtif3 35
  • 54.15 (n)
  • 42.53 (a)
zebrafish
(Danio rerio)
Actinopterygii mtif3 35
  • 52.62 (n)
  • 43.52 (a)
mtif3 36
  • 33 (a)
OneToOne
Species with no ortholog for MTIF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTIF3 Gene

ENSEMBL:
Gene Tree for MTIF3 (if available)
TreeFam:
Gene Tree for MTIF3 (if available)

Paralogs for MTIF3 Gene

Pseudogenes.org Pseudogenes for MTIF3 Gene

genes like me logo Genes that share paralogs with MTIF3: view

No data available for Paralogs for MTIF3 Gene

Variants for MTIF3 Gene

Sequence variations from dbSNP and Humsavar for MTIF3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_031045 -
VAR_031046 -

Structural Variations from Database of Genomic Variants (DGV) for MTIF3 Gene

Variant ID Type Subtype PubMed ID
nsv899951 CNV Loss 21882294

Variation tolerance for MTIF3 Gene

Residual Variation Intolerance Score: 60.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTIF3 Gene

HapMap Linkage Disequilibrium report
MTIF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTIF3 Gene

Disorders for MTIF3 Gene

Relevant External Links for MTIF3

Genetic Association Database (GAD)
MTIF3
Human Genome Epidemiology (HuGE) Navigator
MTIF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTIF3
genes like me logo Genes that share disorders with MTIF3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTIF3 Gene

Publications for MTIF3 Gene

  1. The effect of spermine on the initiation of mitochondrial protein synthesis. (PMID: 19962967) Christian B.E. … Spremulli L.L. (Biochem. Biophys. Res. Commun. 2010) 23 67
  2. The interaction of mammalian mitochondrial translational initiation factor 3 with ribosomes: evolution of terminal extensions in IF3mt. (PMID: 18056078) Haque M.E. … Spremulli L.L. (Nucleic Acids Res. 2008) 23 67
  3. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. (PMID: 12095986) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2002) 2 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for MTIF3 Gene

Sources for MTIF3 Gene

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