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MTIF2 Gene

protein-coding   GIFtS: 60
GCID: GC02M055463

Mitochondrial Translational Initiation Factor 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Translational Initiation Factor 21 2
IF-2(Mt)2 3
IF2(mt)2 3
IF-2mt2
Translation Initiation Factor IF-2, Mitochondrial2
IF-2Mt3

External Ids:    HGNC: 74411   Entrez Gene: 45282   Ensembl: ENSG000000857607   OMIM: 6037665   UniProtKB: P461993   

Export aliases for MTIF2 gene to outside databases

Previous GC identifers: GC02M055501 GC02M055649 GC02M055438 GC02M055375 GC02M055317 GC02M055198


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTIF2 Gene:
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator
tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide,
while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an
85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein
contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast
IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the
proteins. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MTIF2 Gene:
MTIF2 (mitochondrial translational initiation factor 2) is a protein-coding gene. GO annotations related to this gene include GTP binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199
Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA
from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the
hydrolysis of GTP during the formation of the 70S ribosomal complex

Gene Wiki entry for MTIF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTIF2 gene promoter:
         TBP   MEF-2A   TFIID   ZID   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTIF2 promoter sequence
   Search Chromatin IP Primers for MTIF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTIF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

MTIF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTIF2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055463:  view genomic region     (about GC identifiers)

Start:
55,463,731 bp from pter      End:
55,496,483 bp from pter
Size:
32,753 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199 (See protein sequence)
Recommended Name: Translation initiation factor IF-2, mitochondrial precursor  
Size: 727 amino acids; 81317 Da
Subunit: Monomer
Secondary accessions: D6W5D0

Explore the universe of human proteins at neXtProt for MTIF2: NX_P46199

Explore proteomics data for MTIF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTIF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005369.1  NP_002444.2  

    ENSEMBL proteins: 
     ENSP00000384481   ENSP00000263629   ENSP00000403492   ENSP00000393337   ENSP00000388640  
     ENSP00000383880   ENSP00000416057   ENSP00000399531   ENSP00000393025   ENSP00000378099  

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    antibodies-online proteins for MTIF2 (2 products) 

     
    antibodies-online peptides for MTIF2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR000795 EF_GTP-bd_dom
     IPR023115 TIF_IF2_dom3
     IPR005225 Small_GTP-bd_dom
     IPR004161 Transl_elong_EFTu/EF1A_2
     IPR015760 TIF_IF2

    Graphical View of Domain Structure for InterPro Entry P46199

    ProtoNet protein and cluster: P46199

    UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199
    Similarity: Belongs to the IF-2 family


    Find genes that share domains with MTIF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF2M_HUMAN, P46199
    Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA
    from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the
    hydrolysis of GTP during the formation of the 70S ribosomal complex

         Genatlas biochemistry entry for MTIF2:
    mitochondrial translational initiation factor 2,catalyzing the binding of initiation tRNA to mitochondrial 28S
    ribosomes

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity IEA--
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
    GO:0008135translation factor activity, nucleic acid binding ISS--
    GO:0043024ribosomal small subunit binding ISS--
         
    Find genes that share ontologies with MTIF2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MTIF2:
     Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MTIF2

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    hsa-mir-484 (MIRT041908)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IF2M_HUMAN, P46199: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    chloroplast1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with MTIF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTIF2 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for MTIF2
        TNF-alpha/NF-kB Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTIF2
    Interactions:

        Search GeneGlobe Interaction Network for MTIF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTIF2 (P461992, 3 ENSP000002636294) via UniProtKB, MINT, STRING, and/or I2D (see all 158)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKBIBQ156532, 3MINT-47860 I2D: score=4 
    ENSG00000232960P678703, ENSP000003955464I2D: score=1 STRING: ENSP00000395546
    CSNK2BP678703I2D: score=1 
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001732formation of translation initiation complex ISS--
    GO:0006446regulation of translational initiation ISS--
    GO:0007264small GTPase mediated signal transduction ----
    GO:0032790ribosome disassembly ISS--

    Find genes that share ontologies with MTIF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTIF2 (IF2M)

    1 HMDB Compound for MTIF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    7 Novoseek inferred chemical compound relationships for MTIF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly aug 95.6 2 12095986 (1)
    thiostrepton 74.9 6 14698286 (5)
    gtp 69.5 17 19837086 (5), 16968770 (3), 20385143 (2), 10937868 (1) (see all 5)
    aminoacyl-trna 67.1 1 14698286 (1)
    gdp 55.3 7 19837086 (3)
    trna 50.9 2 10727773 (1), 16240709 (1)
    rrna 33.2 4 12869707 (2), 14698286 (1)



    Find genes that share compounds with MTIF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTIF2 gene (2 alternative transcripts): 
    NM_001005369.1  NM_002453.2  

    Unigene Cluster for MTIF2:

    Mitochondrial translational initiation factor 2
    Hs.149894  [show with all ESTs]
    Unigene Representative Sequence: NM_001005369
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403721(uc010yox.2) ENST00000263629(uc002ryo.3 uc002ryp.1)
    ENST00000418823 ENST00000417741 ENST00000446660 ENST00000366137 ENST00000441307
    ENST00000404297 ENST00000420637 ENST00000417363 ENST00000412530 ENST00000394600(uc002ryn.3)

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      QuantiFast Probe-based Assays in human, mouse, rat MTIF2

    Additional mRNA sequence: 

    AF494407.1 AK225184.1 AK307993.1 BC002667.2 BC009845.2 BC017243.1 BC039848.1 BC054048.1 
    BC064977.1 BC067352.1 BC082973.1 BC143541.1 L34600.1 

    15 DOTS entries:

    DT.316190  DT.92005944  DT.92435754  DT.100036537  DT.95070852  DT.100036542  DT.100785719  DT.100785721 
    DT.100785722  DT.40106472  DT.95342069  DT.120977217  DT.120977225  DT.99939771  DT.100036540 

    Selected AceView cDNA sequences (see all 212):

    F04295 BQ774896 BU734875 CB140988 BU753417 BM888464 T09028 BU684812 
    AA427852 NM_002453 BG623953 T16599 AA459016 BM973440 AA873503 BU681583 
    W76546 BM541285 AI347617 BQ774933 BM772446 CA418093 CB120990 AA164432 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTIF2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:        -           -                                                                                       
    SP2:                                                                                                            
    SP3:                    -                                                                                       
    SP4:                                            -     -                                                         
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for MTIF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTIF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTTGGAA
    MTIF2 Expression
    About this image

    MTIF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTIF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149894

    UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199
    Tissue specificity: Expressed in all tissues examined. Highest level in skeletal muscle

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MTIF2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtif21 , 5 mitochondrial translational initiation factor 21, 5 85.42(n)1
    81.29(a)1
      11 (16.77 cM)5
    767841  NM_133767.31  NP_598528.21 
     295264085 
    chicken
    (Gallus gallus)
    Aves MTIF21 mitochondrial translational initiation factor 2 70.99(n)
    66.02(a)
      421213  NM_001199424.1  NP_001186353.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTIF26
    mitochondrial translational initiation factor 2
    66(a)
    1 ↔ 1
    1(255751249-255773078)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.330732 Xenopus laevis transcribed sequence with weak similarity more 77.3(n)    BJ058049.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb59c032 Transcribed sequence with weak similarity to protein more 71.22(n)    57042422 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG124131 , 3 protein biosynthesis translation
    initiation factor3
    CG124131
    48(a)3
    52.32(n)1
    48.7(a)1
      98D43
    433821  NM_143364.31  NP_651621.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F46B6.61 , 3 initiation factor IF-23
    F46B6.61
    42(a)3
    51.07(n)1
    43.96(a)1
      V(9785931-9789414)3
    1793741  NM_001028765.31  NP_001023936.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IFM1(YOL023W)4 Mitochondrial translation initiation factor 2   --   15(278056-280086) 854135  NP_014619.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G111601 AT4G11160 51.38(n)
    44.31(a)
      826717  NM_117186.4  NP_192854.2 
    rice
    (Oryza sativa)
    Liliopsida Os.178742 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.18(n)    AK065778.1 


    ENSEMBL Gene Tree for MTIF2 (if available)
    TreeFam Gene Tree for MTIF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTIF2 gene

    Find genes that share paralogs with MTIF2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MTIF2
    PGOHUM00000244883 PGOHUM00000263303


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTIF2 (see all 884)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847542091,2
    --55463498(+) TTCAGA/GGAAAG 2 -- ds50010--------
    rs1880365661,2
    --55463554(+) AAATCC/GGTGAT 2 -- ds50010--------
    rs560391351,2
    C,F--55463576(+) AATTCA/CCTTTT 2 -- ds500110Minor allele frequency- C:0.33WA NA CSA EA NS 518
    rs1419041321,2
    --55463625(+) GGAGGC/TATCCT 2 -- ds50010--------
    rs1460820421,2
    C--55463639(+) ATAAGA/GTTTCC 2 -- ds50010--------
    rs1922620811,2
    --55463681(+) TGCATA/GTGAAC 2 -- ds50010--------
    rs779964411,2
    C,F--55463691(+) CACATG/TGTAAA 2 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1400303301,2
    C--55463694(+) ATGGTA/GAAACA 2 -- ds50010--------
    rs1858113331,2
    C--55463738(+) TCTACC/TTTCAA 2 -- ds50010--------
    rs1468557361,2
    C--55463798(+) TGGATC/TCCAAG 4 N D mis11Minor allele frequency- T:0.00NA 4504

    HapMap Linkage Disequilibrium report for MTIF2 (55463731 - 55496483 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MTIF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720078CNV Deletion23290073
    nsv874157CNV Loss21882294
    nsv525025CNV Loss19592680
    nsv874156CNV Loss21882294
    nsv522016CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTIF2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603766    OMIM disorders: --


    Find genes that share disorders with MTIF2           About GenesLikeMe

    1 Novoseek inferred disease relationship for MTIF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 10651023 (1)

    Genetic Association Database (GAD): MTIF2
    Human Genome Epidemiology (HuGE) Navigator: MTIF2 (3 documents)

    Export disorders for MTIF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTIF2 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with MTIF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA. (PubMed id 7829522)1, 2, 3, 9 Ma L. and Spremulli L.L. (J. Biol. Chem. 1995)
    2. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)1, 4 Reiling E....Dekker J.M. (Eur. J. Hum. Genet. 2009)
    5. The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene. (PubMed id 12932832)1, 2 Overman R.G. Jr....Farwell M.A. (Biochim. Biophys. Acta 2003)
    6. Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16--&gt;p14 by in situ hybridization and with somatic cell hybrids. (PubMed id 9925935)1, 3 Bonner D.S....Farwell M.A. (Cytogenet. Cell Genet. 1998)
    7. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. (PubMed id 12095986)1, 9 Koc E.C. and Spremulli L.L. (J. Biol. Chem. 2002)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4528 HGNC: 7441 AceView: MTIF2 Ensembl:ENSG00000085760 euGenes: HUgn4528
    ECgene: MTIF2 H-InvDB: MTIF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MTIF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MTIF2 gene:
    Search GeneIP for patents involving MTIF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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