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Aliases for MTIF2 Gene

Aliases for MTIF2 Gene

  • Mitochondrial Translational Initiation Factor 2 2 3
  • IF-2(Mt) 3 4
  • IF2(Mt) 3 4
  • IF-2mt 3 4
  • Translation Initiation Factor IF-2, Mitochondrial 3

External Ids for MTIF2 Gene

Previous GeneCards Identifiers for MTIF2 Gene

  • GC02M055501
  • GC02M055649
  • GC02M055438
  • GC02M055375
  • GC02M055317
  • GC02M055463
  • GC02M055198

Summaries for MTIF2 Gene

Entrez Gene Summary for MTIF2 Gene

  • During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTIF2 Gene

MTIF2 (Mitochondrial Translational Initiation Factor 2) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include GTP binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for MTIF2 Gene

  • One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex

Gene Wiki entry for MTIF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTIF2 Gene

Genomics for MTIF2 Gene

Regulatory Elements for MTIF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTIF2 Gene

Start:
55,236,595 bp from pter
End:
55,269,347 bp from pter
Size:
32,753 bases
Orientation:
Minus strand

Genomic View for MTIF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTIF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTIF2 Gene

Proteins for MTIF2 Gene

  • Protein details for MTIF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    NP_002444.2
    Recommended name:
    Protein Accession:
    NP_002444.2
    Secondary Accessions:

    Protein attributes for MTIF2 Gene

    Size:
    amino acids
    Molecular mass:
    Da
    Quaternary structure:
    No Data Available
  • Protein details for MTIF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46199-IF2M_HUMAN
    Recommended name:
    Translation initiation factor IF-2, mitochondrial
    Protein Accession:
    P46199
    Secondary Accessions:
    • D6W5D0

    Protein attributes for MTIF2 Gene

    Size:
    727 amino acids
    Molecular mass:
    81317 Da
    Quaternary structure:
    • Monomer

neXtProt entry for MTIF2 Gene

Proteomics data for MTIF2 Gene at MOPED

Post-translational modifications for MTIF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTIF2 Gene

Domains for MTIF2 Gene

Suggested Antigen Peptide Sequences for MTIF2 Gene

Graphical View of Domain Structure for InterPro Entry

P46199

UniProtKB/Swiss-Prot:

IF2M_HUMAN :
  • P46199
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
genes like me logo Genes that share domains with MTIF2: view

No data available for Gene Families for MTIF2 Gene

Function for MTIF2 Gene

Molecular function for MTIF2 Gene

GENATLAS Biochemistry:
mitochondrial translational initiation factor 2,catalyzing the binding of initiation tRNA to mitochondrial 28S ribosomes
UniProtKB/Swiss-Prot Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex

Gene Ontology (GO) - Molecular Function for MTIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
GO:0008135 translation factor activity, RNA binding ISS --
GO:0043024 ribosomal small subunit binding ISS --
genes like me logo Genes that share ontologies with MTIF2: view

Phenotypes for MTIF2 Gene

GenomeRNAi human phenotypes for MTIF2:
genes like me logo Genes that share phenotypes with MTIF2: view

Animal Model Products

CRISPR Products

miRNA for MTIF2 Gene

miRTarBase miRNAs that target MTIF2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTIF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTIF2 Gene

Localization for MTIF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTIF2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTIF2 Gene COMPARTMENTS Subcellular localization image for MTIF2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for MTIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion TAS 12095986
genes like me logo Genes that share ontologies with MTIF2: view

Pathways for MTIF2 Gene

genes like me logo Genes that share pathways with MTIF2: view

Pathways by source for MTIF2 Gene

1 BioSystems pathway for MTIF2 Gene

Gene Ontology (GO) - Biological Process for MTIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001732 formation of cytoplasmic translation initiation complex --
GO:0006184 obsolete GTP catabolic process --
GO:0006446 regulation of translational initiation TAS 7829522
GO:0006996 organelle organization TAS --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with MTIF2: view

Compounds for MTIF2 Gene

(1) HMDB Compounds for MTIF2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(7) Novoseek inferred chemical compound relationships for MTIF2 Gene

Compound -log(P) Hits PubMed IDs
poly aug 95.6 1
thiostrepton 74.9 5
gtp 69.5 12
aminoacyl-trna 67.1 1
gdp 55.3 3
genes like me logo Genes that share compounds with MTIF2: view

Transcripts for MTIF2 Gene

Unigene Clusters for MTIF2 Gene

Mitochondrial translational initiation factor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTIF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTIF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2:
SP3: -
SP4: - -
SP5:
SP6: -

Relevant External Links for MTIF2 Gene

GeneLoc Exon Structure for
MTIF2
ECgene alternative splicing isoforms for
MTIF2

Expression for MTIF2 Gene

mRNA expression in normal human tissues for MTIF2 Gene

Protein differential expression in normal tissues for MTIF2 Gene

This gene is overexpressed in Lymph node (14.9), Peripheral blood mononuclear cells (9.6), and Salivary gland (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTIF2 Gene

SOURCE GeneReport for Unigene cluster for MTIF2 Gene Hs.149894

mRNA Expression by UniProt/SwissProt for MTIF2 Gene

NP_002444.2
Tissue specificity: Expressed in all tissues examined. Highest level in skeletal muscle
genes like me logo Genes that share expressions with MTIF2: view

Expression partners for MTIF2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTIF2 Gene

Orthologs for MTIF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MTIF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTIF2 35
  • 88.54 (n)
  • 85.01 (a)
MTIF2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTIF2 35
  • 89.55 (n)
  • 85.14 (a)
MTIF2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtif2 35
  • 85.42 (n)
  • 81.29 (a)
Mtif2 16
Mtif2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTIF2 35
  • 99.54 (n)
  • 99.17 (a)
MTIF2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtif2 35
  • 85.74 (n)
  • 83.36 (a)
oppossum
(Monodelphis domestica)
Mammalia MTIF2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTIF2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTIF2 35
  • 70.99 (n)
  • 66.02 (a)
MTIF2 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTIF2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtif2 35
  • 66.07 (n)
  • 63.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33073 35
zebrafish
(Danio rerio)
Actinopterygii mtif2 35
  • 61.74 (n)
  • 60.69 (a)
wufb59c03 35
mtif2 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12413 37
  • 48 (a)
CG12413 35
  • 52.32 (n)
  • 48.7 (a)
CG12413 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001670 35
  • 50.16 (n)
  • 49.68 (a)
worm
(Caenorhabditis elegans)
Secernentea F46B6.6 37
  • 42 (a)
F46B6.6 35
  • 51.07 (n)
  • 43.96 (a)
F46B6.6 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IFM1 36
  • 34 (a)
OneToOne
IFM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G11160 35
  • 51.38 (n)
  • 44.31 (a)
rice
(Oryza sativa)
Liliopsida Os.17874 35
Os09g0515500 35
  • 53.44 (n)
  • 46.03 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15211 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.556 36
  • 46 (a)
OneToOne
Species with no ortholog for MTIF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTIF2 Gene

ENSEMBL:
Gene Tree for MTIF2 (if available)
TreeFam:
Gene Tree for MTIF2 (if available)

Paralogs for MTIF2 Gene

Pseudogenes.org Pseudogenes for MTIF2 Gene

genes like me logo Genes that share paralogs with MTIF2: view

No data available for Paralogs for MTIF2 Gene

Variants for MTIF2 Gene

Sequence variations from dbSNP and Humsavar for MTIF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11357 - 55,242,979(-) GTGAT(A/G)TAAGT missense, reference
rs749221 -- 55,269,694(+) TGGCT(A/C)CTCTG upstream-variant-2KB
rs1056445 - 55,263,683(-) GCTCA(A/C)TGGGG missense, reference, utr-variant-5-prime
rs1134722 -- 55,263,652(-) CTTCT(A/G)GTAAC reference, synonymous-codon, utr-variant-5-prime
rs1437397 -- 55,255,440(-) TTATA(C/T)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTIF2 Gene

Variant ID Type Subtype PubMed ID
esv2720078 CNV Deletion 23290073
nsv522016 CNV Gain 19592680
nsv874156 CNV Loss 21882294
nsv525025 CNV Loss 19592680
nsv874157 CNV Loss 21882294

Relevant External Links for MTIF2 Gene

HapMap Linkage Disequilibrium report
MTIF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTIF2 Gene

Disorders for MTIF2 Gene

(1) Novoseek inferred disease relationships for MTIF2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for MTIF2

Genetic Association Database (GAD)
MTIF2
Human Genome Epidemiology (HuGE) Navigator
MTIF2
genes like me logo Genes that share disorders with MTIF2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for MTIF2 Gene

Publications for MTIF2 Gene

  1. Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA. (PMID: 7829522) Ma L. … Spremulli L.L. (J. Biol. Chem. 1995) 2 3 4 23
  2. The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene. (PMID: 12932832) Overman R.G. Jr. … Farwell M.A. (Biochim. Biophys. Acta 2003) 3 4
  3. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. (PMID: 12095986) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2002) 3 23
  4. Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16-->p14 by in situ hybridization and with somatic cell hybrids. (PMID: 9925935) Bonner D.S. … Farwell M.A. (Cytogenet. Cell Genet. 1998) 2 3
  5. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PMID: 19209188) Reiling E. … Dekker J.M. (Eur. J. Hum. Genet. 2009) 3 48

Products for MTIF2 Gene

Sources for MTIF2 Gene

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