Aliases for MTIF2 Gene
External Ids for MTIF2 Gene
Previous GeneCards Identifiers for MTIF2 Gene
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTIF2 Gene
MTIF2 (Mitochondrial Translational Initiation Factor 2) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include GTP binding and translation initiation factor activity.
UniProtKB/Swiss-Prot for MTIF2 Gene
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex