Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MTHFR Gene

protein-coding   GIFtS: 68
GCID: GC01M011845

Methylenetetrahydrofolate Reductase (NAD(P)H)

(Previous name: 5,10-methylenetetrahydrofolate reductase (NADPH))
  See MTHFR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Methylenetetrahydrofolate Reductase (NAD(P)H)1 2
5,10-Methylenetetrahydrofolate Reductase (NADPH)1 2
EC 1.5.1.203 8
Methylenetetrahydrofolate Reductase2

External Ids:    HGNC: 74361   Entrez Gene: 45242   Ensembl: ENSG000001770007   OMIM: 6070935   UniProtKB: P428983   

Export aliases for MTHFR gene to outside databases

Previous GC identifers: GC01U990112 GC01M011694 GC01M011459 GC01M011556 GC01M011780 GC01M011000


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MTHFR Gene:
The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to
5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this
gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute
leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.(provided
by RefSeq, Oct 2009)

GeneCards Summary for MTHFR Gene:
MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)) is a protein-coding gene. Diseases associated with MTHFR include vascular disease, and thromboembolism. GO annotations related to this gene include methylenetetrahydrofolate reductase (NAD(P)H) activity and modified amino acid binding.

UniProtKB/Swiss-Prot: MTHR_HUMAN, P42898
Function: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate
for homocysteine remethylation to methionine

Gene Wiki entry for MTHFR (Methylenetetrahydrofolate reductase) Gene

PharmGKB "VIP" summary for MTHFR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTHFR gene promoter:
         p53   AML1a   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTHFR promoter sequence
   Search Chromatin IP Primers for MTHFR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTHFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.3

MTHFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTHFR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M011845:  view genomic region     (about GC identifiers)

Start:
11,845,780 bp from pter      End:
11,866,977 bp from pter
Size:
21,198 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MTHR_HUMAN, P42898 (See protein sequence)
Recommended Name: Methylenetetrahydrofolate reductase  
Size: 656 amino acids; 74597 Da
Cofactor: FAD
Subunit: Homodimer
Secondary accessions: B2R7A6 Q5SNW6 Q5SNW9 Q7Z6M6 Q8IU73 Q9UQR2
Alternative splicing: 2 isoforms:  P42898-1   P42898-2   

Explore the universe of human proteins at neXtProt for MTHFR: NX_P42898

Explore proteomics data for MTHFR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MTHFR (P42898) (see all 9)
     DEFPNGR  EDVRPIFWA  GAVNLISRFDRM  GILTINSQPNIN 


    See MTHFR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005948.3  
    ENSEMBL proteins: 
     ENSP00000365777   ENSP00000365775   ENSP00000365770   ENSP00000405082   ENSP00000408307  
     ENSP00000398908   ENSP00000400460   ENSP00000365669   ENSP00000365767  
    Reactome Protein details: P42898

    MTHFR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MTHFR
    OriGene Protein Over-expression Lysate for MTHFR
    OriGene MassSpec for MTHFR
    OriGene Custom Protein Services for MTHFR
    GenScript Custom Purified and Recombinant Proteins Services for MTHFR
    Novus Biologicals MTHFR Protein
    Novus Biologicals MTHFR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTHFR

     
    Search eBioscience for Proteins for MTHFR 

     
    antibodies-online proteins for MTHFR (5 products) 

     
    Search antibodies-online for peptides for MTHFR

    MTHFR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MTHFR
    OriGene Custom Antibody Services for MTHFR
    Novus Biologicals MTHFR Antibodies
    Abcam antibodies for MTHFR
    Cloud-Clone Corp. Antibodies for MTHFR
    ThermoFisher Antibody for MTHFR
    antibodies-online antibodies for MTHFR (59 products) 

    MTHFR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTHFR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTHFR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTHFR
    Cloud-Clone Corp. CLIAs for MTHFR
    Search eBioscience for ELISAs for MTHFR 
    antibodies-online kits for MTHFR (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR003171 Mehydrof_redctse
     IPR004621 Fadh2_euk

    Graphical View of Domain Structure for InterPro Entry P42898

    ProtoNet protein and cluster: P42898

    1 Blocks protein domain: IPB003171 Methylenetetrahydrofolate reductase

    UniProtKB/Swiss-Prot: MTHR_HUMAN, P42898
    Similarity: Belongs to the methylenetetrahydrofolate reductase family


    Find genes that share domains with MTHFR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTHR_HUMAN, P42898
    Function: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate
    for homocysteine remethylation to methionine
    Catalytic activity: 5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H
    Enzyme regulation: Allosterically regulated by S-adenosylmethionine

         Genatlas biochemistry entry for MTHFR:
    5-10 methylenetetrahydrofolate (THF) reductase,NADPH dependent,70kDa,reducing 5-10 methylene THF to,5 methyl-THF
    for methionine biosynthesis,with a common variant putatively involved in occlusive vascular disease,neural tube
    defects,colon cancer and adult akute leukemia. And a mutation responsible of increased mortality risk in men in
    middle and old age

         Enzyme Number (IUBMB): EC 1.5.1.201 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004489methylenetetrahydrofolate reductase (NAD(P)H) activity TAS--
    GO:0050660flavin adenine dinucleotide binding IEA--
    GO:0050661NADP binding IEA--
    GO:0072341modified amino acid binding IDA--
         
    Find genes that share ontologies with MTHFR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MTHFR:
     Decreased Wnt reporter activit 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mthfr):
     growth/size/body  homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging 
     nervous system  no phenotypic analysis  reproductive system  skeleton  vision/eye 

    Find genes that share phenotypes with MTHFR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mthfrtm1Rzn for MTHFR

       genOway: Develop your customized and physiologically relevant rodent model for MTHFR

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTHFR:
    hsa-mir-16-5p (MIRT031648), hsa-mir-423-3p (MIRT042604), hsa-mir-103a-3p (MIRT027114)

    Block miRNA regulation of human, mouse, rat MTHFR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTHFR (see all 31):
    hsa-miR-3164 hsa-miR-26a-2* hsa-miR-4299 hsa-miR-764 hsa-miR-1205 hsa-miR-650 hsa-miR-4267 hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTHFR
    Predesigned siRNA for gene silencing in human, mouse, rat MTHFR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTHFR

    Clone
    Products:
         
    OriGene clones in human, mouse for MTHFR (see all 7)
    OriGene ORF clones in mouse, rat for MTHFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTHFR (NM_005957)
    Sino Biological Human cDNA Clone for MTHFR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTHFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTHFR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTHFR
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTHFR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTHFR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular3
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0043005neuron projection IEA--

    Find genes that share ontologies with MTHFR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MTHFR About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1One carbon pool by folate
    One carbon pool by folate0.53
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics0.35
    One Carbon Metabolism0.53
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.34
    Trans-sulfuration and one carbon metabolism0.43
    Antimetabolite Pathway - Folate Cycle, Pharmacodynamics0.00
    2Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacodynamics0.00
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    5Folate Metabolism
    Folate Metabolism0.54
    Vitamin B12 Metabolism0.54


    Find genes that share SuperPaths with MTHFR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for MTHFR (see all 7)
        One Carbon Metabolism
    Fluoropyrimidine Activity
    Selenium Pathway
    Folate Metabolism
    Vitamin B12 Metabolism


    1 Reactome Pathway for MTHFR
        Metabolism of folate and pterines

    4 PharmGKB Pathways for MTHFR
        Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacodynamics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    3 Kegg Pathways  (Kegg details for MTHFR):
        One carbon pool by folate
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: MTHR_HUMAN, P42898
    Pathway: One-carbon metabolism; tetrahydrofolate interconversion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTHFR: 

              Lung Cancer in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MTHFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for MTHFR (P428983 ENSP000003657754) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMB1P206183, ENSP000002621934I2D: score=4 STRING: ENSP00000262193
    SARS2Q9NP813, ENSP000002214314I2D: score=1 STRING: ENSP00000221431
    LSM8O957773, ENSP000002492994I2D: score=4 STRING: ENSP00000249299
    GGPS1O957493, ENSP000002828414I2D: score=1 STRING: ENSP00000282841
    ATICP319393, ENSP000002369594I2D: score=1 STRING: ENSP00000236959
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006520cellular amino acid metabolic process TAS7647779
    GO:0006555methionine metabolic process ----
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--

    Find genes that share ontologies with MTHFR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTHFR (MTHR)

    Selected HMDB Compounds for MTHFR (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    5,10-Methylene-THF5,10-methylene-THF (see all 8)31690-11-6--
    5-Methyltetrahydrofolic acid5-Methyl tetrahydrofolate (see all 17)134-35-0--
    CyanocobalaminDimethylbenzimidazoylcobamide (see all 92)68-19-9--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    1 DrugBank Compound for MTHFR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tetrahydrofolic acid5,6,7,8-tetrahydrofolate (see all 3)135-16-0targetcofactor12605391 10893069 11457468 11730351 10196703

    Selected Novoseek inferred chemical compound relationships for MTHFR gene (see all 84)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    homocysteine 96.8 1798 11979347 (7), 9863549 (6), 11744407 (5), 15777550 (5) (see all 99)
    folate 96.1 1642 11979347 (5), 16002818 (5), 11299748 (5), 16950805 (5) (see all 99)
    5-methyltetrahydrofolate 91.6 218 19398669 (4), 12733064 (3), 12949355 (2), 9067278 (2) (see all 99)
    vitamin b12 90.6 240 11979347 (5), 10780318 (5), 9264011 (3), 17295607 (3) (see all 99)
    methionine 86.8 531 16024724 (4), 18351371 (3), 9587027 (3), 11730351 (3) (see all 99)
    cystathionine 86.4 105 11216902 (2), 11292330 (2), 10517251 (2), 20160465 (2) (see all 66)
    b vitamins 81.3 42 16379339 (2), 19180309 (2), 18053312 (2), 17332146 (2) (see all 22)
    thymidylate 80.2 165 15510613 (2), 15598763 (2), 16045580 (2), 16920564 (2) (see all 91)
    vitamin b6 79.5 53 19389261 (2), 17141597 (2), 19838916 (2), 17436239 (2) (see all 34)
    5,10-methenyltetrahydrofolate 75 3 16712703 (1), 15503105 (1)

    Selected PharmGKB related drug/compound annotations for MTHFR gene (see all 19)    About this table
    Drug/compound PharmGKB Annotation
    vitamin b-complex, plainCA  
    antipsychoticsCA  
    benazeprilCA  
    bevacizumabCA  
    capecitabineCA  
    carboplatinCA  
    cisplatinCA  
    cyanocobalaminCA  
    cyclophosphamideCA  
    disulfiramCA  



    Find genes that share compounds with MTHFR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MTHFR gene: 
    NM_005957.4  

    Unigene Cluster for MTHFR:

    Methylenetetrahydrofolate reductase (NAD(P)H)
    Hs.214142  [show with all ESTs]
    Unigene Representative Sequence: NM_005957
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376592(uc001atb.1 uc001atc.2) ENST00000376590 ENST00000376585(uc001atd.1 uc009vnd.1)
    ENST00000418034 ENST00000413656 ENST00000423400 ENST00000431243 ENST00000376486
    ENST00000376583
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTHFR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTHFR (see all 31):
    hsa-miR-3164 hsa-miR-26a-2* hsa-miR-4299 hsa-miR-764 hsa-miR-1205 hsa-miR-650 hsa-miR-4267 hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTHFR
    Predesigned siRNA for gene silencing in human, mouse, rat MTHFR
    Clone
    Products:
         
    OriGene clones in human, mouse for MTHFR (see all 7)
    OriGene ORF clones in mouse, rat for MTHFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTHFR (NM_005957)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTHFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTHFR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MTHFR
    OriGene qSTAR qPCR primer pairs in human, mouse for MTHFR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTHFR
      QuantiTect SYBR Green Assays in human, mouse, rat MTHFR
      QuantiFast Probe-based Assays in human, mouse, rat MTHFR

    Additional mRNA sequence: 

    AB209113.1 AJ237672.1 AK312907.1 AY046560.1 AY046562.1 AY046563.1 AY046564.1 AY046565.1 
    BC011614.2 BC018766.1 BC053509.1 JQ429447.1 

    12 DOTS entries:

    DT.87046276  DT.40285938  DT.100785174  DT.121440318  DT.100020900  DT.100785171  DT.121440369  DT.438299 
    DT.91685016  DT.95237745  DT.121440328  DT.121440354 

    Selected AceView cDNA sequences (see all 121):

    AI333711 AY046562 AI570123 AY046561 BF724956 AI358668 AY046563 BE244583 
    BU501685 AY046560 AY046565 AY046564 AL048482 BM310814 CB528721 C01118 
    AA339525 F23245 CF144282 H29733 CF122109 BC018766 BQ924752 AI334054 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTHFR (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
    SP1:                                                                    -                             -           -                                             
    SP2:                                                                                                                                                  -         
    SP3:                          -     -     -     -     -                 -                             -           -                                             
    SP4:                          -     -     -     -     -                 -                             -                                                         
    SP5:                          -     -     -     -     -                                                                                                         

    ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for MTHFR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MTHFR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTAATGGG
    MTHFR Expression
    About this image


    MTHFR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Lung (Respiratory System)
             Trachea
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Eye (Sensory Organs)
             Lens
    MTHFR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTHFR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.214142
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTHFR: 
              Lung Cancer in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MTHFR
    OriGene qSTAR qPCR primer pairs in human, mouse for MTHFR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTHFR
    QuantiTect SYBR Green Assays in human, mouse, rat MTHFR
    QuantiFast Probe-based Assays in human, mouse, rat MTHFR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTHFR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MTHFR gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mthfr1 , 5 5,10-methylenetetrahydrofolate reductase1, 5 86.78(n)1
    90.35(a)1
      4 (78.67 cM)5
    177691  NM_001161798.11  NP_001155270.11 
     1480390775 
    chicken
    (Gallus gallus)
    Aves MTHFR1 methylenetetrahydrofolate reductase (NAD(P)H) 78.64(n)
    86.08(a)
      419489  XM_417645.4  XP_417645.3 
    lizard
    (Anolis carolinensis)
    Reptilia MTHFR6
    methylenetetrahydrofolate reductase (NAD(P)H)
    71(a)
    1 ↔ 1
    AAWZ02036459(4993-5232)
    African clawed frog
    (Xenopus laevis)
    Amphibia mthfr-prov2 5,10-methylenetetrahydrofolate reductase (NADPH) 76.22(n)    BC046708.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mthfr1 methylenetetrahydrofolate reductase (NAD(P)H) 73.9(n)
    80.23(a)
      567547  NM_001128255.1  NP_001121727.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG75606
    --
    22(a)
    1 ↔ 1
    3L(11418250-11419495)
    worm
    (Caenorhabditis elegans)
    Secernentea mthf-11 mthf-1 53.28(n)
    49.26(a)
      174254  NM_171025.6  NP_741028.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MET13(YGL125W)4
    MET131
    Major isozyme of methylenetetrahydrofolate reductase, more4
    MET131
    51.55(n)1
    44.11(a)1
      7(272520-274322)4
    8527521, 4  NP_011390.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MTHFR11 MTHFR1 52.03(n)
    45.86(a)
      825167  NM_115860.3  NP_191556.1 
    rice
    (Oryza sativa)
    Liliopsida AK121351.12   -- 72.01(n)    AK121351.1 


    ENSEMBL Gene Tree for MTHFR (if available)
    TreeFam Gene Tree for MTHFR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MTHFR gene

    Find genes that share paralogs with MTHFR           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MTHFR
    PGOHUM00000251049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    MTHR_HUMAN, P42898: Genetic variation in MTHFR influences susceptibility to occlusive vascular disease, neural tube
    defects (NTD), colon cancer and acute leukemia


    Selected SNPs for MTHFR (see all 501)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016187811,2,,4
    CMethylenetetrahydrofolate reductase deficiency (MTHFRD)4 --11863022(+) ATCGCC/G/TGCCTC 3 Q P R mis11EU 1323
    VAR_0095314
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0095312 L P mis40--------
    VAR_0095364
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0095362 P L mis40--------
    VAR_0043244
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0043242 R C mis40--------
    VAR_0095374
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0095372 E K mis40--------
    VAR_0043204
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0043202 R Q mis40--------
    VAR_0043234
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0043232 R C mis40--------
    VAR_0095354
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0095352 G D mis40--------
    VAR_0043224
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0043222 P L mis40--------
    VAR_0043194
    Methylenetetrahydrofolate reductase deficiency (MTHFRD)4--see VAR_0043192 R Q mis40--------

    HapMap Linkage Disequilibrium report for MTHFR (11845780 - 11866977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MTHFR:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv141n71CNV Loss21882294
    dgv140n71CNV Loss21882294
    nsv518652CNV Loss19592680
    nsv871919CNV Loss21882294
    nsv871014CNV Gain21882294

    Human Gene Mutation Database (HGMD): MTHFR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTHFR
    DNA2.0 Custom Variant and Variant Library Synthesis for MTHFR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607093   
    OMIM disorders: 236250  181500  601634  188050  
    UniProtKB/Swiss-Prot: MTHR_HUMAN, P42898
  • Methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]: Autosomal recessive disorder with a
    wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe
    mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural
    tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,
    resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of
    heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry
  • Folate-sensitive neural tube defects (FS-NTD) [MIM:601634]: The most common NTDs are open spina bifida
    (myelomeningocele) and anencephaly. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • Selected diseases for MTHFR (see all 91):    
    About MalaCards
    vascular disease    thromboembolism    neural tube defects    homocystinuria due to mthfr deficiency
    retinal vascular disease    mthfr deficiency    post-traumatic epilepsy    isolated anencephaly/exencephaly
    methotrexate poisoning    mthfr thermolabile variant    homocysteinemia    mthfr gene mutation
    acute leukemia    hyperhomocysteinemia    cerebral atherosclerosis    exstrophy of the bladder
    anencephaly    inferior vena cava interruption    limb reduction defect    cervical spina bifida cystica

    Selected diseases from the University of Copenhagen DISEASES database for MTHFR (see all 27):
    Hyperhomocysteinemia     Thrombophilia     Homocystinuria     Cerebrovascular accident
    Placental abruption     Hypertension     Spina bifida     Vitamin B12 deficiency
    Colorectal cancer     Heart disease     Cleft lip     Atherosclerosis
    Protein C deficiency     Down syndrome     Migraine     Pulmonary embolism
    Retinal vein occlusion     Schizophrenia     Antiphospholipid syndrome     Antithrombin III deficiency

    Find genes that share disorders with MTHFR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MTHFR gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperhomocysteinemia 95.5 343 16909866 (4), 18234410 (3), 11747974 (3), 19748043 (3) (see all 99)
    methylenetetrahydrofolate reductase deficiency 93.1 51 10961793 (3), 12142069 (2), 18539994 (2), 18616155 (2) (see all 43)
    thrombophilia 86.5 85 14691342 (2), 14747183 (2), 15834246 (2), 9890294 (1) (see all 51)
    neural tube defects 86.2 119 12431255 (3), 10602111 (3), 10100053 (2), 10732818 (2) (see all 69)
    folate deficiency 82.9 43 10452905 (2), 14734201 (2), 16950805 (2), 11440783 (2) (see all 28)
    homocysteinemia 82 20 16055253 (2), 15834927 (2), 18220649 (1), 18328637 (1) (see all 13)
    homocystinuria 81.1 50 9490685 (3), 8752689 (3), 15217352 (3), 8124871 (3) (see all 27)
    venous thrombosis 75.3 75 9490685 (3), 10837091 (2), 18293456 (2), 17353498 (2) (see all 50)
    vascular diseases 75.2 89 8989110 (3), 10477457 (2), 17099857 (2), 10318658 (2) (see all 61)
    apc resistance 71.1 18 18191809 (1), 10847236 (1), 15609280 (1), 16797917 (1) (see all 16)

    Genetic Association Database (GAD): MTHFR
    Human Genome Epidemiology (HuGE) Navigator: MTHFR (2229 documents)

    Export disorders for MTHFR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MTHFR gene, integrated from 10 sources (see all 3522):
    (articles sorted by number of sources associating them with MTHFR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the genes regulating methylene tetrahydrofolate reductase (MTHFR C--&gt;T677) and cystathione beta-synthase (CBS G--&gt;A919, CBS T--&gt;c833) are not associated with myocardial infarction in African Americans. (PubMed id 11457468)1, 4, 7, 9 Dilley A....Evatt B.L. (Thromb. Res. 2001)
    2. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. (PubMed id 10536004)1, 2, 4, 9 Skibola C.F.... Morgan G. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    3. Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE). (PubMed id 12605391)1, 4, 7, 9 Tsai A.W....Folsom A.R. (Am. J. Hematol. 2003)
    4. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. (PubMed id 7920641)1, 2, 3, 9 Goyette P.... Rozen R. (Nat. Genet. 1994)
    5. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. (PubMed id 15534175)1, 2, 4 Casas J.P.... Sharma P. (Arch. Neurol. 2004)
    6. The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer. (PubMed id 15161007)1, 4, 9 Oyama K....Watanabe G. (Anticancer Res. 2004)
    7. Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes. (PubMed id 16234003)1, 4, 9 Matsubayashi H....Goggins M. (Clin. Gastroenterol. Hepatol. 2005)
    8. An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis. (PubMed id 11558898)1, 4, 9 Kawamoto R....Konishi I. (J. Hum. Genet. 2001)
    9. Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR. (PubMed id 8940272)1, 2, 9 Goyette P.... Rozen R. (Am. J. Hum. Genet. 1996)
    10. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients. (PubMed id 20078613)1, 4, 9 Etienne-Grimaldi M.C....de Gramont A. (Br J Clin Pharmacol 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4524 HGNC: 7436 AceView: MTHFR Ensembl:ENSG00000177000 euGenes: HUgn4524
    ECgene: MTHFR Kegg: 4524 H-InvDB: MTHFR

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MTHFR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTHFR Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MTHFR[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mthfr/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=MTHFR
    Wikipedia http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MTHFR gene:
    Search GeneIP for patents involving MTHFR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MTHFR   OriGene RNAi products in human, mouse, rat for MTHFR  
     OriGene qPCR primer pairs and template standards for MTHFR   OriGene Protein Over-expression Lysate for MTHFR  
     OriGene MassSpec for MTHFR   OriGene clones in human, mouse for MTHFR  
     OriGene qSTAR qPCR primer pairs in human, mouse for MTHFR   OriGene Purified Protein for MTHFR  
     OriGene ORF clones in mouse, rat for MTHFR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MTHFR   OriGene Custom Protein Services for MTHFR  

     
     
     Block miRNA regulation of human, mouse, rat MTHFR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MTHFR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTHFR Predesigned siRNA for gene silencing in human, mouse, rat MTHFR
     QuantiFast Probe-based Assays in human, mouse, rat MTHFR QuantiTect SYBR Green Assays in human, mouse, rat MTHFR
     PCR Arrays including human, mouse, rat MTHFR Search Chromatin IP Primers for MTHFR
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTHFR  GeneGlobe Interaction Network for MTHFR
     Regulatory tfbs in MTHFR promoter
     GenScript Custom Purified and Recombinant Proteins Services for MTHFR GenScript cDNA clones with any tag delivered in your preferred vector for MTHFR
     GenScript Custom Assay Services for MTHFR GenScript Custom overexpressing Cell Line Services for MTHFR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MTHFR (MTHR)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MTHFR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MTHFR antibodies
     MTHFR proteins
     MTHFR lysates
     Antibodies for MTHFR
     See all of Abcam's Antibodies, Kits and Proteins for MTHFR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MTHFR
     Antibodies for MTHFR
     ELISAs for MTHFR
     CLIAs for MTHFR



     Browse ESI BIO Cell Lines and PureStem Progenitors for MTHFR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTHFR
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MTHFR
     SwitchGear Promoter luciferase reporter plasmids for MTHFR
     ThermoFisher Antibody for MTHFR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTHFR
     Browse compounds at ApexBio
     Search Addgene for plasmids for MTHFR
      Search eBioscience for proteins for MTHFR
      Search eBioscience for elisas for MTHFR
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MTHFR
     antibodies-online antibodies for MTHFR (59 products)
     antibodies-online kits for MTHFR (14 products)
      Search antibodies-online for peptides for MTHFR
     antibodies-online proteins for MTHFR (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MTHFR gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4