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MTHFD2L Gene

protein-coding   GIFtS: 50
GCID: GC04P074979

Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent)...

  Search for MTHFD2L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2-Like1 2
MTHFD2-like2 3
NADP-Dependent Methylenetetrahydrofolate Dehydrogenase 2-Like Protein2 3
Probable Bifunctional Methylenetetrahydrofolate
Dehydrogenase/Cyclohydrolase 22

External Ids:    HGNC: 318651   Entrez Gene: 4410242   Ensembl: ENSG000001637387   OMIM: 6140475   UniProtKB: Q9H9033   

Export aliases for MTHFD2L gene to outside databases

Previous GC identifers: GC04P075358 GC04P075207 GC04P070834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTHFD2L Gene:
MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like) is a protein-coding gene. GO annotations related to this gene include methylenetetrahydrofolate dehydrogenase (NADP+) activity and formate-tetrahydrofolate ligase activity. An important paralog of this gene is MTHFD2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MTHFD2L gene promoter:
         AREB6   LHX3b/Lhx3b   AML1a   p53   Cart-1   LHX3a/Lhx3a   Pax-4a   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTHFD2L promoter sequence
   Search Chromatin IP Primers for MTHFD2L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTHFD2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

MTHFD2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTHFD2L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074979:  view genomic region     (about GC identifiers)

Start:
74,979,891 bp from pter      End:
75,168,816 bp from pter
Size:
188,926 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903 (See protein sequence)
Recommended Name: Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2  
Size: 347 amino acids; 37315 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=AAH32771.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14441.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in
the N-terminal part;
Secondary accessions: Q6P079 Q8N560
Alternative splicing: 5 isoforms:  Q9H903-4   Q9H903-1   Q9H903-2   Q9H903-3   Q9H903-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTHFD2L: NX_Q9H903

Explore proteomics data for MTHFD2L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTHFD2L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138450.1  
    ENSEMBL proteins: 
     ENSP00000391327   ENSP00000409391   ENSP00000387614   ENSP00000352012   ENSP00000321984  
     ENSP00000379108   ENSP00000330982   ENSP00000405692  

    MTHFD2L Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MTHFD2L

     
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    Search eBioscience for ELISAs for MTHFD2L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR020631 THF_DH/CycHdrlase_NAD-bd_dom
     IPR020630 THF_DH/CycHdrlase_cat_dom
     IPR020867 THF_DH/CycHdrlase_CS
     IPR016040 NAD(P)-bd_dom
     IPR000672 THF_DH/CycHdrlase

    Graphical View of Domain Structure for InterPro Entry Q9H903

    ProtoNet protein and cluster: Q9H903

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family


    Find genes that share domains with MTHFD2L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTD2L_HUMAN, Q9H903
    Catalytic activity: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH
    Catalytic activity: 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004329NOT formate-tetrahydrofolate ligase activity IBA--
    GO:0004477methenyltetrahydrofolate cyclohydrolase activity IBA--
    GO:0004487methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA--
    GO:0004488methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA--
         
    Find genes that share ontologies with MTHFD2L           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Mthfd2l (no phenotypes)

    Find genes that share phenotypes with MTHFD2L           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTHFD2L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTHFD2L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTHFD2L
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    miRNA
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    miRTarBase miRNAs that target MTHFD2L:
    hsa-mir-96-5p (MIRT027905)

    Block miRNA regulation of human, mouse, rat MTHFD2L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTHFD2L (see all 16):
    hsa-miR-495 hsa-miR-1271 hsa-miR-7-1* hsa-miR-3613-3p hsa-miR-3674 hsa-miR-3121-3p hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidMTHFD2L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTHFD2L
    Predesigned siRNA for gene silencing in human, mouse, rat MTHFD2L

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MTHFD2L (NM_001144978)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTHFD2L

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    Browse ESI BIO Cell Lines and PureStem Progenitors for MTHFD2L 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTHFD2L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTD2L_HUMAN, Q9H903: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IBA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005829NOT cytosol IBA--

    Find genes that share ontologies with MTHFD2L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTHFD2L About    
    See pathways by source

    SuperPathContained pathways About
    1One carbon pool by folate
    One carbon pool by folate0.53
    Trans-sulfuration and one carbon metabolism0.43
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with MTHFD2L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MTHFD2L
        Trans-sulfuration and one carbon metabolism


    2 Kegg Pathways  (Kegg details for MTHFD2L):
        One carbon pool by folate
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Pathway: One-carbon metabolism; tetrahydrofolate interconversion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTHFD2L
    Interactions:

        Search GeneGlobe Interaction Network for MTHFD2L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTHFD2L (ENSP000003791084) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1L1ENSP000003770834STRING: ENSP00000377083
    ALDH1L2ENSP000002584944STRING: ENSP00000258494
    AMTENSP000002735884STRING: ENSP00000273588
    ATICENSP000002369594STRING: ENSP00000236959
    FTCDENSP000002916704STRING: ENSP00000291670
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000105histidine biosynthetic process IEA--
    GO:0006164purine nucleotide biosynthetic process IEA--
    GO:0006730one-carbon metabolic process IBA--
    GO:0009086methionine biosynthetic process IEA--
    GO:0009396folic acid-containing compound biosynthetic process IEA--

    Find genes that share ontologies with MTHFD2L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTHFD2L (MTD2L)

    3 HMDB Compounds for MTHFD2L    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTHFD2L gene (2 alternative transcripts): 
    NM_001144978.1  NM_001004346.2  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429519(uc003hhn.1 uc011cbj.2) ENST00000490698 ENST00000475291
    ENST00000429335(uc003hho.2) ENST00000423607(uc003hhs.2) ENST00000461101(uc003hhr.4)
    ENST00000359107 ENST00000325278(uc003hhu.3) ENST00000484725 ENST00000492183
    ENST00000461856 ENST00000465255 ENST00000490128 ENST00000395759(uc011cbk.2)
    ENST00000331145 ENST00000433372
    miRNA
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    Block miRNA regulation of human, mouse, rat MTHFD2L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTHFD2L (see all 16):
    hsa-miR-495 hsa-miR-1271 hsa-miR-7-1* hsa-miR-3613-3p hsa-miR-3674 hsa-miR-3121-3p hsa-miR-129-3p hsa-miR-129*
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    Selected AceView cDNA sequences (see all 92):

    BQ213693 BI793282 AK021544 CA777914 AU131312 BI793226 AU117623 AA620707 
    BE788846 BM127086 AA459358 BX103541 CK818818 AA463678 AA702016 AA620671 
    BX093787 BI793148 BI792994 BX105242 BC065771 AA288019 AU117191 BX102439 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MTHFD2L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                -     -                 -                                                   
    SP2:                                                                                -     -                     
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                    -                                                                                       


    ECgene alternative splicing isoforms for MTHFD2L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTHFD2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAGAAAT
    MTHFD2L Expression
    About this image


    MTHFD2L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
    MTHFD2L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTHFD2L Protein Expression

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Tissue specificity: Isoform 1, isoform 4 and isoform 5 are expressed in brain and placenta

        Custom PCR Arrays for MTHFD2L
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    QuantiFast Probe-based Assays in human, mouse, rat MTHFD2L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTHFD2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MTHFD2L gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mthfd2l1 , 5 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) more1, 5 83.93(n)1
    89.94(a)1
      5 (44.78 cM)5
    6655631  NM_026788.11  NP_081064.11 
     909311965 
    chicken
    (Gallus gallus)
    Aves MTHFD2L1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) more 74.9(n)
    78.35(a)
      770327  XM_001233662.3  XP_001233663.3 
    lizard
    (Anolis carolinensis)
    Reptilia MTHFD2L6
    methylenetetrahydrofolate dehydrogenase (NADP+ dep...
    80(a)
    1 ↔ 1
    6(60166039-60193531)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mthfd2l1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) more 74.44(n)
    80(a)
      100497864  XM_002941768.1  XP_002941814.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mthfd2l6
    methylenetetrahydrofolate dehydrogenase (NADP+ dep...
    60(a)
    1 ↔ 1
    8(33237880-33251868) ENSDARG00000054199
    fruit fly
    (Drosophila melanogaster)
    Insecta Nmdmc6
    NAD-dependent methylenetetrahydrofolate dehydrogen...
    52(a)
    1 → many
    3R(4868226-4876271)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTD1(YKR080W)4 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, more   --   11(590395-591357) 853955  NP_013006.1 


    ENSEMBL Gene Tree for MTHFD2L (if available)
    TreeFam Gene Tree for MTHFD2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTHFD2L gene
    MTHFD22  MTHFD12  MTHFD1L2  
    4 SIMAP similar genes for MTHFD2L using alignment to 3 protein entries:     MTD2L_HUMAN (see all proteins):
    tmp_locus_16    MTHFD2    MTHFD1    MTHFD1L

    Find genes that share paralogs with MTHFD2L           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MTHFD2L
    PGOHUM00000259959


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTHFD2L (see all 2708)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5144511,2
    C--75021837(-) caacaC/Ggaaga 1 -- us2k1 trp311Minor allele frequency- G:0.01NA WA CSA 254
    rs1864717341,2
    --75021971(+) TTCTTA/TACCTT 1 -- us2k10--------
    rs1896458291,2
    --75021974(+) TTAACC/TTTTGG 1 -- us2k10--------
    rs1387813681,2
    --75022054(+) AGTATA/GTAGCC 1 -- us2k10--------
    rs286078921,2
    C,F--75022110(+) ATCTAC/TGTCTT 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs738275531,2
    C,F--75022116(+) GTCTTT/CTTATG 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1823305871,2
    --75022159(+) AATATC/TCCATT 1 -- us2k10--------
    rs1429173071,2
    --75022181(+) TCACCA/GCTTAT 1 -- us2k10--------
    rs1507895491,2
    --75022461(+) TCAGCA/GGTTCT 1 -- us2k10--------
    rs1380808181,2
    --75022529(+) TGATAC/TTGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTHFD2L (74979891 - 75168816 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MTHFD2L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662787CNV Deletion23128226
    esv2421669CNV Deletion20811451
    esv998628CNV Insertion20482838
    nsv437397CNV Loss16327808
    esv29295CNV Loss19812545
    nsv509908CNV Loss20534489
    esv8809CNV Gain19470904
    nsv525980CNV Gain19592680
    nsv441890CNV CNV18776908

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614047    OMIM disorders: --


    Find genes that share disorders with MTHFD2L           About GenesLikeMe

    Genetic Association Database (GAD): MTHFD2L
    Human Genome Epidemiology (HuGE) Navigator: MTHFD2L (1 document)

    Export disorders for MTHFD2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTHFD2L gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MTHFD2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues. (PubMed id 21163947)1, 2, 3 Bolusani S.... Appling D.R. (J. Biol. Chem. 2011)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441024 HGNC: 31865 AceView: FLJ13105andMGC72244 Ensembl:ENSG00000163738 euGenes: HUgn441024
    ECgene: MTHFD2L Kegg: 441024 H-InvDB: MTHFD2L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTHFD2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MTHFD2L gene:
    Search GeneIP for patents involving MTHFD2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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