Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTHFD2L Gene

protein-coding   GIFtS: 51
GCID: GC04P074979

methylenetetrahydrofolate dehydrogenase (NADP+ dependent)...

 Explore 3 diseases affiliated with
MTHFD2L via our new
 Human Malady Compendium 
Biological research products
for MTHFD2L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2-Like1 2
MTHFD2-Like1
NADP-Dependent Methylenetetrahydrofolate Dehydrogenase 2-Like Protein2 3
MGC722441
Probable Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase 22

External Ids:    HGNC: 318651   Entrez Gene: 4410242   Ensembl: ENSG000001637387   OMIM: 6140475   UniProtKB: Q9H9033   

Export aliases for MTHFD2L gene to outside databases

Previous GC identifers: GC04P075358 GC04P075207 GC04P070834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTHFD2L gene promoter:
         AREB6   LHX3b/Lhx3b   AML1a   p53   Cart-1   LHX3a/Lhx3a   Pax-4a   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTHFD2L promoter sequence
   Search SABiosciences Chromatin IP Primers for MTHFD2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTHFD2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

MTHFD2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTHFD2L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074979:  view genomic region     (about GC identifiers)

Start:
74,979,891 bp from pter      End:
75,168,816 bp from pter
Size:
188,926 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903 (See protein sequence)
Recommended Name: Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2  
Size: 347 amino acids; 37315 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity)
Sequence caution: Sequence=AAH32771.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14441.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the
N-terminal part;
Secondary accessions: Q6P079 Q8N560
Alternative splicing: 5 isoforms:  Q9H903-4   Q9H903-1   Q9H903-2   Q9H903-3   Q9H903-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTHFD2L: NX_Q9H903

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H903

  • MTHFD2L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001138450.1  
    ENSEMBL proteins: 
     ENSP00000391327   ENSP00000409391   ENSP00000387614   ENSP00000352012   ENSP00000321984  
     ENSP00000379108   ENSP00000330982   ENSP00000405692  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MTHFD2L
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for MTHFD2L 
    GenScript Custom Purified and Recombinant Proteins Services for MTHFD2L
    Novus Biologicals MTHFD2L Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MTHFD2L

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IBA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005829NOT cytosol IBA--


    MTHFD2L for ontologies           About GeneDecksing



    MTHFD2L Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: MTHFD2L
    OriGene Custom Antibody Services for MTHFD2L 
    GenScript Custom Superior Antibodies Services for MTHFD2L
    Novus Biologicals MTHFD2L Antibodies
    Search for Antibodies for MTHFD2L at Abcam  
    Uscn Antibodies for MTHFD2L
    ThermoFisher Antibodies for MTHFD2L

    Assay Products for MTHFD2L: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTHFD2L
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MTHFD2L


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MTHFD2L for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR020631 THF_DH/CycHdrlase_NAD-bd_dom
     IPR016040 NAD(P)-bd_dom
     IPR000672 THF_DH/CycHdrlase
     IPR020630 THF_DH/CycHdrlase_cat_dom
     IPR020867 THF_DH/CycHdrlase_CS

    Graphical View of Domain Structure for InterPro Entry Q9H903

    ProtoNet protein and cluster: Q9H903

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Catalytic activity: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH
    Catalytic activity: 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: MTHFD2L
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTHFD2L
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MTHFD2L (see all 16):
    hsa-miR-495 hsa-miR-1271 hsa-miR-7-1* hsa-miR-3613-3p hsa-miR-3674 hsa-miR-3121-3p hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidMTHFD2L 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTHFD2L (see all 7)
    OriGene shRNA RFP: MTHFD2L
    OriGene siRNA: MTHFD2L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTHFD2L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTHFD2L

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTHFD2L (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTHFD2L
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MTHFD2L (NM_001144978)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTHFD2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTHFD2L 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTHFD2L
    Search LifeMap BioReagents cell lines for MTHFD2L

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTHFD2L

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0004329NOT formate-tetrahydrofolate ligase activity IBA--
    GO:0004477methenyltetrahydrofolate cyclohydrolase activity IBA--
    GO:0004487methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA--
    GO:0004488methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA--


    MTHFD2L for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1One Carbon Metabolism
    One carbon pool by folate0.52
    2Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for MTHFD2L):
        One carbon pool by folate
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Pathway: One-carbon metabolism; tetrahydrofolate interconversion


    MTHFD2L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTHFD2L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for MTHFD2L (ENSP000003791084) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1L1ENSP000003770834STRING: ENSP00000377083
    ALDH1L2ENSP000002584944STRING: ENSP00000258494
    AMTENSP000002735884STRING: ENSP00000273588
    ATICENSP000002369594STRING: ENSP00000236959
    FTCDENSP000002916704STRING: ENSP00000291670
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000105histidine biosynthetic process IEA--
    GO:0006164purine nucleotide biosynthetic process IEA--
    GO:0006730one-carbon metabolic process IBA--
    GO:0009086methionine biosynthetic process IEA--
    GO:0009396folic acid-containing compound biosynthetic process IEA--


    MTHFD2L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTHFD2L

    3 HMDB Compounds for MTHFD2L    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Search CenterWatch for drugs/clinical trials and news about MTHFD2L / MTD2L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTHFD2L gene (2 alternative transcripts): 
    NM_001144978.1  NM_001004346.2  

    Unigene Clusters for MTHFD2L:

    Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
    Hs.721011  [show with all ESTs], Hs.740700  [show with all ESTs]
    Unigene Representative Sequences: AK021544, AK122799
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429519(uc003hhn.1 uc011cbj.2) ENST00000490698 ENST00000475291
    ENST00000429335(uc003hho.2) ENST00000423607(uc003hhs.2) ENST00000461101(uc003hhr.4)
    ENST00000359107 ENST00000325278(uc003hhu.3) ENST00000484725 ENST00000492183
    ENST00000461856 ENST00000465255 ENST00000490128 ENST00000395759(uc011cbk.2)
    ENST00000331145 ENST00000433372

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: MTHFD2L
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTHFD2L
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MTHFD2L (see all 16):
    hsa-miR-495 hsa-miR-1271 hsa-miR-7-1* hsa-miR-3613-3p hsa-miR-3674 hsa-miR-3121-3p hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidMTHFD2L 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTHFD2L (see all 7)
    OriGene shRNA RFP: MTHFD2L
    OriGene siRNA: MTHFD2L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTHFD2L
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTHFD2L (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTHFD2L
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MTHFD2L (NM_001144978)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTHFD2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTHFD2L 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTHFD2L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTHFD2L
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTHFD2L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTHFD2L

    Additional cDNA sequence: 

    AK122799.1 BC032771.1 BC041943.1 BC065771.1 

    13 DOTS entries:

    DT.411039  DT.92042560  DT.121253725  DT.101977498  DT.99935638  DT.100669785  DT.99978859  DT.100744634 
    DT.95190869  DT.121253662  DT.91694477  DT.411041  DT.91640464 

    24/92 AceView cDNA sequences (see all 92):

    BQ213693 BI793282 AK021544 CA777914 AU131312 AU117623 AA620707 BE788846 
    BM127086 BX103541 CK818818 AA463678 AA702016 AA620671 BX093787 BI793148 
    BI792994 AU117191 AA288019 BC065771 BI793226 AA459358 BX105242 BX102439 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MTHFD2L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                -     -                 -                                                   
    SP2:                                                                                -     -                     
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                    -                                                                                       


    ECgene alternative splicing isoforms for MTHFD2L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTHFD2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAGAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MTHFD2L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTHFD2L

    SOURCE GeneReport for Unigene clusters: Hs.721011 Hs.740700

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Tissue specificity: Isoform 1, isoform 4 and isoform 5 are expressed in brain and placenta

        SABiosciences Custom PCR Arrays for MTHFD2L
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTHFD2L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTHFD2L
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTHFD2L
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTHFD2L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTHFD2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MTHFD2L gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mthfd2l1 , 5 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) more1, 5 83.93(n)1
    89.94(a)1
      5 (44.78 cM)5
    6655631  NM_026788.11  NP_081064.11 
     909311965 
    chicken
    (Gallus gallus)
    Aves MTHFD2L1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) more 76.72(n)
    81.97(a)
      770327  XM_001233662.2  XP_001233663.2 
    lizard
    (Anolis carolinensis)
    Reptilia MTHFD2L6
    --
    79(a)
    1 ↔ 1
    6(60178632-60192031)
    zebrafish
    (Danio rerio)
    Actinopterygii mthfd2l6
    methylenetetrahydrofolate dehydrogenase (NADP+ dep...
    61(a)
    1 ↔ 1
    8(33237880-33251868)
    fruit fly
    (Drosophila melanogaster)
    Insecta Nmdmc6
    NAD-dependent methylenetetrahydrofolate dehydrogen...
    52(a)
    1 → many
    3R(4868226-4876271)
    worm
    (Caenorhabditis elegans)
    Secernentea dao-36
    Dauer or Aging adult Overexpression family member ...
    38(a)
    possible ortholog
    X(8084159-8086501)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G122906
    AT4G006206
    (see all 4)
    Amino acid dehydrogenase family protein
    (see all 4)
    44(a)
    39(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    3(3919502-3921519)
    4(259028-261019)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    bifunctional protein folD, putative, expressed
    (see all 3)
    47(a)
    38(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    5(2925746-2928065)
    2(1086158-1089626)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria folD6
    bifunctional 5,10-methylene-tetrahydrofolate dehyd...
    45(a)
    1 → many
    Chromosome(556098-556964)


    ENSEMBL Gene Tree for MTHFD2L (if available)
    TreeFam Gene Tree for MTHFD2L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTHFD2L gene
    MTHFD22  
    4 SIMAP similar genes for MTHFD2L using alignment to 3 protein entries:     MTD2L_HUMAN (see all proteins):
    tmp_locus_16    MTHFD2    MTHFD1    MTHFD1L

    MTHFD2L for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MTHFD2L
    PGOHUM00000259959


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for MTHFD2L
         3 CNVs: 92202 38568 63863
         2 Indels: 60477 10766
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTHFD2L
    DNA2.0 Custom Variant and Variant Library Synthesis for MTHFD2L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MTHFD2L for disorders           About GeneDecksing

    OMIM gene information: 614047    OMIM disorders: --

    3 diseases for MTHFD2L:    About MalaCards
    pneumonia    tuberculosis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: MTHFD2L (1 document)

    Export disorders for MTHFD2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTHFD2L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MTHFD2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian MTHFD2L encodes a mitochondrial methylenete trahydrofolate dehydrogenase isozyme expressed in adult tissues. (PubMed id 21163947)1, 2, 3 Bolusani S....Appling D.R. (2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 441024 HGNC: 31865 AceView: FLJ13105andMGC72244 Ensembl:ENSG00000163738 euGenes: HUgn441024
    ECgene: MTHFD2L Kegg: 441024 H-InvDB: MTHFD2L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTHFD2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTHFD2L gene:
    Search GeneIP for patents involving MTHFD2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for MTHFD2L   OriGene shRNA RFP for MTHFD2L  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTHFD2L   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTHFD2L  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MTHFD2L   OriGene 3'-UTR Clone for MTHFD2L  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTHFD2L   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTHFD2L  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for MTHFD2L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MTHFD2L   OriGene Custom Protein Services for MTHFD2L  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTHFD2L
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTHFD2L
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTHFD2L
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTHFD2L
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTHFD2L
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTHFD2L
     GenScript Custom Purified and Recombinant Proteins Services for MTHFD2L GenScript cDNA clones with any tag delivered in your preferred vector for MTHFD2L
     GenScript Custom Assay Services for MTHFD2L GenScript Custom Superior Antibodies Services for MTHFD2L
     GenScript Custom overexpressing Cell Line Services for MTHFD2L CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MTHFD2L promoter
     Search Chromatin IP Primers for MTHFD2L
     RT2 qPCR Primer Assay in human, mouse, rat MTHFD2L
     Search GNC Networks for MTHFD2L
     SABiosciences Custom PCR Arrays for MTHFD2L
     Search Tocris compounds for MTHFD2L
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MTHFD2L antibodies
     MTHFD2L proteins
     Search for Antibodies for MTHFD2L at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MTHFD2L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MTHFD2L Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MTHFD2L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTHFD2L
     SwitchGear 3'UTR luciferase reporter plasmids for MTHFD2L
     SwitchGear Promoter luciferase reporter plasmids for MTHFD2L
     ThermoFisher Antibodies for MTHFD2L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTHFD2L
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MTHFD2L gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4