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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTHFD2L Gene

protein-coding   GIFtS: 53
GCID: GC04P074979

Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent)...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2-Like1 2
MTHFD2-like2 3
NADP-Dependent Methylenetetrahydrofolate Dehydrogenase 2-Like Protein2 3
Probable Bifunctional Methylenetetrahydrofolate
Dehydrogenase/Cyclohydrolase 22

External Ids:    HGNC: 318651   Entrez Gene: 4410242   Ensembl: ENSG000001637387   OMIM: 6140475   UniProtKB: Q9H9033   

Export aliases for MTHFD2L gene to outside databases

Previous GC identifers: GC04P075358 GC04P075207 GC04P070834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MTHFD2L Gene: 
MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like) is a protein-coding gene. Diseases associated with MTHFD2L include smallpox, and pneumonia, and among its related super-pathways are One Carbon Metabolism and Metabolism. GO annotations related to this gene include methenyltetrahydrofolate cyclohydrolase activity and nucleotide binding. An important paralog of this gene is MTHFD2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTHFD2L gene promoter:
         AREB6   LHX3b/Lhx3b   AML1a   p53   Cart-1   LHX3a/Lhx3a   Pax-4a   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTHFD2L promoter sequence
   Search SABiosciences Chromatin IP Primers for MTHFD2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTHFD2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

MTHFD2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTHFD2L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074979:  view genomic region     (about GC identifiers)

Start:
74,979,891 bp from pter      End:
75,168,816 bp from pter
Size:
188,926 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903 (See protein sequence)
Recommended Name: Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2  
Size: 347 amino acids; 37315 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity)
Sequence caution: Sequence=AAH32771.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14441.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in
the N-terminal part;
Secondary accessions: Q6P079 Q8N560
Alternative splicing: 5 isoforms:  Q9H903-4   Q9H903-1   Q9H903-2   Q9H903-3   Q9H903-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTHFD2L: NX_Q9H903

Explore proteomics data for MTHFD2L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H903

  • MTHFD2L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTHFD2L Protein Expression
    REFSEQ proteins: NP_001138450.1  
    ENSEMBL proteins: 
     ENSP00000391327   ENSP00000409391   ENSP00000387614   ENSP00000352012   ENSP00000321984  
     ENSP00000379108   ENSP00000330982   ENSP00000405692  

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    Cloud-Clone Corp. Proteins for MTHFD2L 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IBA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005829NOT cytosol IBA--

    MTHFD2L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR020631 THF_DH/CycHdrlase_NAD-bd_dom
     IPR020630 THF_DH/CycHdrlase_cat_dom
     IPR020867 THF_DH/CycHdrlase_CS
     IPR016040 NAD(P)-bd_dom
     IPR000672 THF_DH/CycHdrlase

    Graphical View of Domain Structure for InterPro Entry Q9H903

    ProtoNet protein and cluster: Q9H903

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family


    MTHFD2L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTD2L_HUMAN, Q9H903
    Catalytic activity: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH
    Catalytic activity: 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004329NOT formate-tetrahydrofolate ligase activity IBA--
    GO:0004477methenyltetrahydrofolate cyclohydrolase activity IBA--
    GO:0004487methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA--
    GO:0004488methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA--
         
    MTHFD2L for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidMTHFD2L 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MTHFD2L About                                                                                                See pathways by source

    SuperPathContained pathways About
    1One Carbon Metabolism
    One carbon pool by folate0.53
    2Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for MTHFD2L):
        One carbon pool by folate
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Pathway: One-carbon metabolism; tetrahydrofolate interconversion


    MTHFD2L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTHFD2L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for MTHFD2L (ENSP000003791084) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1L1ENSP000003770834STRING: ENSP00000377083
    ALDH1L2ENSP000002584944STRING: ENSP00000258494
    AMTENSP000002735884STRING: ENSP00000273588
    ATICENSP000002369594STRING: ENSP00000236959
    FTCDENSP000002916704STRING: ENSP00000291670
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000105histidine biosynthetic process IEA--
    GO:0006164purine nucleotide biosynthetic process IEA--
    GO:0006730one-carbon metabolic process IBA--
    GO:0009086methionine biosynthetic process IEA--
    GO:0009396folic acid-containing compound biosynthetic process IEA--

    MTHFD2L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTHFD2L (MTD2L)

    3 HMDB Compounds for MTHFD2L    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--

    Search CenterWatch for drugs/clinical trials and news about MTHFD2L / MTD2L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTHFD2L gene (2 alternative transcripts): 
    NM_001144978.1  NM_001004346.2  

    Unigene Clusters for MTHFD2L:

    Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
    Hs.721011  [show with all ESTs], Hs.740700  [show with all ESTs]
    Unigene Representative Sequences: AK021544, AK122799
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429519(uc003hhn.1 uc011cbj.2) ENST00000490698 ENST00000475291
    ENST00000429335(uc003hho.2) ENST00000423607(uc003hhs.2) ENST00000461101(uc003hhr.4)
    ENST00000359107 ENST00000325278(uc003hhu.3) ENST00000484725 ENST00000492183
    ENST00000461856 ENST00000465255 ENST00000490128 ENST00000395759(uc011cbk.2)
    ENST00000331145 ENST00000433372
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-495 hsa-miR-1271 hsa-miR-7-1* hsa-miR-3613-3p hsa-miR-3674 hsa-miR-3121-3p hsa-miR-129-3p hsa-miR-129*
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    Additional mRNA sequence: 

    AK122799.1 BC032771.1 BC041943.1 BC065771.1 

    13 DOTS entries:

    DT.411039  DT.92042560  DT.121253725  DT.101977498  DT.99935638  DT.100669785  DT.99978859  DT.100744634 
    DT.95190869  DT.121253662  DT.91694477  DT.411041  DT.91640464 

    24/92 AceView cDNA sequences (see all 92):

    AU117623 AK021544 AA288019 BC065771 BX105242 AA620707 BM127086 BX093787 
    AU117191 CK818818 BQ213693 BE788846 BX103541 CA777914 BI793282 BI792994 
    BI793148 BI793226 AU131312 AA463678 AA459358 AA620671 AA702016 AA370783 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MTHFD2L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                -     -                 -                                                   
    SP2:                                                                                -     -                     
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                    -                                                                                       


    ECgene alternative splicing isoforms for MTHFD2L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTHFD2L expression in normal human tissues (normalized intensities)      MTHFD2L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAGAAAT
    MTHFD2L Expression
    About this image


    MTHFD2L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human corneal endothelial cells
             cd31+ cells   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             platelets   
     
     Kidney (Urinary System)
             renal vesicle e12.5   
     
     Bone (Muscoskeletal System)
             mandibular prominence tissue e10.0   
     
     Head Mesenchyme (Muscoskeletal System)
             mandibular prominence tissue e10.0   

    See MTHFD2L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTHFD2L

    SOURCE GeneReport for Unigene clusters: Hs.721011 Hs.740700

    UniProtKB/Swiss-Prot: MTD2L_HUMAN, Q9H903
    Tissue specificity: Isoform 1, isoform 4 and isoform 5 are expressed in brain and placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MTHFD2L gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mthfd2l1 , 5 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) more1, 5 83.93(n)1
    89.94(a)1
      5 (44.78 cM)5
    6655631  NM_026788.11  NP_081064.11 
     909311965 
    chicken
    (Gallus gallus)
    Aves MTHFD2L1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) more 76.72(n)
    81.97(a)
      770327  XM_001233662.2  XP_001233663.2 
    lizard
    (Anolis carolinensis)
    Reptilia MTHFD2L6
    methylenetetrahydrofolate dehydrogenase (NADP+ dep...
    80(a)
    1 ↔ 1
    6(60166039-60193531)
    zebrafish
    (Danio rerio)
    Actinopterygii mthfd2l6
    methylenetetrahydrofolate dehydrogenase (NADP+ dep...
    60(a)
    1 ↔ 1
    8(33237880-33251868)
    fruit fly
    (Drosophila melanogaster)
    Insecta Nmdmc6
    NAD-dependent methylenetetrahydrofolate dehydrogen...
    52(a)
    1 → many
    3R(4868226-4876271)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTD1(YKR080W)4 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, more   --   11(590395-591357) 853955  NP_013006.1 


    ENSEMBL Gene Tree for MTHFD2L (if available)
    TreeFam Gene Tree for MTHFD2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTHFD2L gene
    MTHFD22  
    4 SIMAP similar genes for MTHFD2L using alignment to 3 protein entries:     MTD2L_HUMAN (see all proteins):
    tmp_locus_16    MTHFD2    MTHFD1    MTHFD1L

    MTHFD2L for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MTHFD2L
    PGOHUM00000259959


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2708 SNPs in MTHFD2L are shown (see all 2708)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5144511,2
    C--75021837(-) caacaC/Ggaaga 1 -- us2k1 trp311Minor allele frequency- G:0.01NA WA CSA 254
    rs1864717341,2
    --75021971(+) TTCTTA/TACCTT 1 -- us2k10--------
    rs1896458291,2
    --75021974(+) TTAACC/TTTTGG 1 -- us2k10--------
    rs1387813681,2
    --75022054(+) AGTATA/GTAGCC 1 -- us2k10--------
    rs286078921,2
    C,F--75022110(+) ATCTAC/TGTCTT 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs738275531,2
    C,F--75022116(+) GTCTTT/CTTATG 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1823305871,2
    --75022159(+) AATATC/TCCATT 1 -- us2k10--------
    rs1429173071,2
    --75022181(+) TCACCA/GCTTAT 1 -- us2k10--------
    rs1507895491,2
    --75022461(+) TCAGCA/GGTTCT 1 -- us2k10--------
    rs1380808181,2
    --75022529(+) TGATAC/TTGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTHFD2L (74979891 - 75168816 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MTHFD2L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662787CNV Deletion23128226
    esv2421669CNV Deletion20811451
    esv998628CNV Insertion20482838
    nsv437397CNV Loss16327808
    esv29295CNV Loss19812545
    nsv509908CNV Loss20534489
    esv8809CNV Gain19470904
    nsv525980CNV Gain19592680
    nsv441890CNV CNV18776908

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614047    OMIM disorders: --

    3 diseases for MTHFD2L:    About MalaCards
    smallpox    pneumonia    tuberculosis


    MTHFD2L for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTHFD2L
    Human Genome Epidemiology (HuGE) Navigator: MTHFD2L (1 document)

    Export disorders for MTHFD2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTHFD2L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MTHFD2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian MTHFD2L encodes a mitochondrial methylenete trahydrofolate dehydrogenase isozyme expressed in adult tissues. (PubMed id 21163947)1, 2, 3 Bolusani S....Appling D.R. (2011)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 441024 HGNC: 31865 AceView: FLJ13105andMGC72244 Ensembl:ENSG00000163738 euGenes: HUgn441024
    ECgene: MTHFD2L Kegg: 441024 H-InvDB: MTHFD2L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTHFD2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTHFD2L gene:
    Search GeneIP for patents involving MTHFD2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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