Aliases for MTHFD2 Gene
Aliases for MTHFD2 Gene
External Ids for MTHFD2 Gene
- HGNC: 7434
- Entrez Gene: 10797
- Ensembl: ENSG00000065911
- OMIM: 604887
- UniProtKB: P13995
Previous GeneCards Identifiers for MTHFD2 Gene
- GC02P074563
- GC02P074638
- GC02P074383
- GC02P074400
- GC02P074337
- GC02P074095
- GC02P074425
- GC02P074161
Summaries for MTHFD2 Gene
-
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
GeneCards Summary for MTHFD2 Gene
MTHFD2 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase) is a Protein Coding gene. Among its related pathways are One carbon pool by folate and Folate Metabolism. GO annotations related to this gene include magnesium ion binding and formate-tetrahydrofolate ligase activity. An important paralog of this gene is MTHFD2L.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTHFD2 Gene
Genomics for MTHFD2 Gene
Regulatory Elements for MTHFD2 Gene
Enhancers for MTHFD2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MTHFD2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MTHFD2 Gene
- Chromosome:
- 2
- Start:
- 74,198,562 bp from pter
- End:
- 74,217,565 bp from pter
- Size:
- 19,004 bases
- Orientation:
- Plus strand
Genomic View for MTHFD2 Gene
Genes around MTHFD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p13.1 by Ensembl
- 2p13.1 by Entrez Gene
- 2p13.1 by HGNC
MTHFD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTHFD2 Gene
Proteins for MTHFD2 Gene
-
Protein details for MTHFD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13995-MTDC_HUMAN
- Recommended name:
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
- Protein Accession:
- P13995
- Q53G90
- Q53GV5
- Q53S36
- Q7Z650
Protein attributes for MTHFD2 Gene
- Size:
- 350 amino acids
- Molecular mass:
- 37895 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- This NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD.
- SequenceCaution:
-
- Sequence=AAX93061.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96546.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96761.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA34431.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MTHFD2 Gene
Post-translational modifications for MTHFD2 Gene
Other Protein References for MTHFD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for MTHFD2 (MTHFD2)
- Novus Biologicals Antibodies for MTHFD2
- Invitrogen Antibodies for MTHFD2
- antibodies-online Antibodies for MTHFD2: See all 35
- GeneTex MTHFD2 antibody for MTHFD2
-
Santa Cruz Biotechnology (SCBT) Antibodies for MTHFD2
Protein Products
-
OriGene Purified Proteins for MTHFD2
- Search Origene for MassSpec and Protein Over-expression Lysates for MTHFD2
- Origene Custom Protein Services for MTHFD2
- ProSpec Recombinant Proteins for MTHFD2
- antibodies-online Proteins for MTHFD2: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MTHFD2
-
ProSci Proteins for MTHFD2
Assay Products
- antibodies-online Kits for MTHFD2: See all 1
No data available for DME Specific Peptides for MTHFD2 Gene
Domains & Families for MTHFD2 Gene
Protein Domains for MTHFD2 Gene
Suggested Antigen Peptide Sequences for MTHFD2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55007, highly similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (B4DY35_HUMAN)
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTDC_HUMAN)
- cDNA FLJ52745, highly similar to Bifunctional methylenetetrahydrofolatedehydrogenase/cyclohydrolase, mitochondrial (Q7Z650_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13995UniProtKB/Swiss-Prot:
MTDC_HUMAN :- Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
- Family:
-
- Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
No data available for Gene Families for MTHFD2 Gene
Function for MTHFD2 Gene
Molecular function for MTHFD2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 8218174 |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity | TAS | -- |
| GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity | TAS | -- |
| GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity | IDA,IEA | 8218174 |
Phenotypes for MTHFD2 Gene
- MGI mutant phenotypes for MTHFD2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MTHFD2:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
- Decreased shRNA abundance
- Increased shRNA abundance (Z-score > 2)
- Decreased viability of wild-type and TP53 knockout cells
Animal Models for MTHFD2 Gene
- MGI Knock Outs for MTHFD2:
-
- Mthfd2 tm1Rmk
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTHFD2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MTHFD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTHFD2 gene
- Search ViGene Biosciences for MTHFD2
CRISPR Products
-
OriGene CRISPR knockouts for MTHFD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTHFD2
- GenScript: Design CRISPR guide RNA sequences for MTHFD2
miRNA for MTHFD2 Gene
- miRTarBase miRNAs that target MTHFD2
-
- hsa-mir-1-3p (MIRT001354)
- hsa-mir-155-5p (MIRT021039)
- hsa-mir-16-5p (MIRT031940)
- hsa-mir-421 (MIRT039360)
- hsa-mir-30e-5p (MIRT044162)
- hsa-mir-29c-3p (MIRT044234)
- hsa-mir-30d-5p (MIRT047797)
- hsa-mir-30a-3p (MIRT089464)
- hsa-mir-30d-3p (MIRT089468)
- hsa-mir-30e-3p (MIRT089471)
- hsa-mir-559 (MIRT089479)
- hsa-mir-548b-5p (MIRT089481)
- hsa-mir-548a-5p (MIRT089482)
- hsa-mir-548c-5p (MIRT089483)
- hsa-mir-548d-5p (MIRT089485)
- hsa-mir-548j-5p (MIRT089486)
- hsa-mir-548k (MIRT089487)
- hsa-mir-548l (MIRT089488)
- hsa-mir-548f-5p (MIRT089489)
- hsa-mir-548g-5p (MIRT089490)
- hsa-mir-548h-5p (MIRT089491)
- hsa-mir-548p (MIRT089492)
- hsa-mir-548i (MIRT089493)
- hsa-mir-548w (MIRT089494)
- hsa-mir-548x-5p (MIRT089495)
- hsa-mir-548y (MIRT089499)
- hsa-mir-548o-5p (MIRT089500)
- hsa-mir-548ab (MIRT089501)
- hsa-mir-548ad-5p (MIRT089502)
- hsa-mir-548ae-5p (MIRT089503)
- hsa-mir-548aj-5p (MIRT089504)
- hsa-mir-548ak (MIRT089505)
- hsa-mir-548am-5p (MIRT089506)
- hsa-mir-4670-3p (MIRT089507)
- hsa-mir-548ap-5p (MIRT089508)
- hsa-mir-548aq-5p (MIRT089509)
- hsa-mir-548ar-5p (MIRT089510)
- hsa-mir-548as-5p (MIRT089511)
- hsa-mir-548au-5p (MIRT089512)
- hsa-mir-548av-5p (MIRT089513)
- hsa-mir-548ay-5p (MIRT089514)
- hsa-mir-8054 (MIRT089515)
- hsa-mir-548bb-5p (MIRT089516)
- hsa-mir-186-5p (MIRT207304)
- hsa-mir-568 (MIRT207305)
- hsa-mir-3668 (MIRT207307)
- hsa-mir-4477a (MIRT303605)
- hsa-mir-9-5p (MIRT303632)
- hsa-mir-548n (MIRT303633)
- hsa-mir-4257 (MIRT353936)
- hsa-mir-2467-3p (MIRT353944)
- hsa-mir-302c-5p (MIRT353966)
- hsa-mir-500a-5p (MIRT353987)
- hsa-mir-501-5p (MIRT353988)
- hsa-mir-5584-3p (MIRT353996)
- hsa-mir-576-3p (MIRT354008)
- hsa-mir-7109-5p (MIRT472856)
- hsa-mir-4291 (MIRT472858)
- hsa-mir-4472 (MIRT472859)
- hsa-mir-4447 (MIRT472860)
- hsa-mir-92a-2-5p (MIRT472861)
- hsa-mir-6885-5p (MIRT472862)
- hsa-mir-328-5p (MIRT472863)
- hsa-mir-6887-5p (MIRT472864)
- hsa-mir-6795-5p (MIRT472865)
- hsa-mir-625-5p (MIRT472866)
- hsa-mir-650 (MIRT472867)
- hsa-mir-3612 (MIRT472868)
- hsa-mir-6134 (MIRT472869)
- hsa-mir-1827 (MIRT472870)
- hsa-mir-4459 (MIRT472871)
- hsa-mir-4433a-3p (MIRT472872)
- hsa-mir-4768-3p (MIRT472873)
- hsa-mir-761 (MIRT472874)
- hsa-mir-3619-5p (MIRT472875)
- hsa-mir-214-3p (MIRT472876)
- hsa-mir-922 (MIRT472877)
- hsa-mir-3617-3p (MIRT472878)
- hsa-mir-6511a-5p (MIRT472879)
- hsa-mir-1910-3p (MIRT472880)
- hsa-mir-34a-3p (MIRT472881)
- hsa-mir-4643 (MIRT506490)
- hsa-mir-8485 (MIRT506491)
- hsa-mir-6844 (MIRT511134)
- hsa-mir-3165 (MIRT511135)
- hsa-mir-6880-5p (MIRT511136)
- hsa-mir-4277 (MIRT511137)
- hsa-mir-8071 (MIRT511138)
- hsa-mir-382-5p (MIRT511139)
- hsa-mir-495-5p (MIRT511140)
- hsa-mir-1910-5p (MIRT522415)
- hsa-mir-455-3p (MIRT522416)
- hsa-mir-1324 (MIRT535817)
- hsa-mir-5683 (MIRT535818)
- hsa-mir-548as-3p (MIRT535819)
- hsa-mir-500a-3p (MIRT556043)
- hsa-mir-6771-5p (MIRT556044)
- hsa-mir-425-3p (MIRT556045)
- hsa-mir-7977 (MIRT556046)
- hsa-mir-3622b-5p (MIRT556047)
- hsa-mir-6804-3p (MIRT556048)
- hsa-mir-20b-3p (MIRT556049)
- hsa-mir-6746-5p (MIRT556050)
- hsa-mir-502-3p (MIRT556051)
- hsa-mir-501-3p (MIRT556052)
- hsa-mir-2114-5p (MIRT556053)
- hsa-mir-5588-3p (MIRT556054)
- hsa-mir-4314 (MIRT636406)
- hsa-mir-5196-5p (MIRT636407)
- hsa-mir-4747-5p (MIRT636408)
- hsa-mir-6735-3p (MIRT636409)
- hsa-mir-6506-5p (MIRT636410)
- hsa-mir-619-5p (MIRT636411)
- hsa-mir-3192-5p (MIRT636412)
- hsa-mir-4646-5p (MIRT636413)
- hsa-mir-204-3p (MIRT636414)
- hsa-mir-330-5p (MIRT636415)
- hsa-mir-326 (MIRT636416)
- hsa-mir-2276-5p (MIRT636417)
- hsa-mir-4650-5p (MIRT636418)
- hsa-mir-4687-5p (MIRT636419)
miRNA Products
- Search ViGene Biosciences for MTHFD2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MTHFD2
- Browse OriGene Inhibitory RNA Products For MTHFD2
-
ViGene Biosciences ready-to-package AAV shRNAs for MTHFD2 gene
Clone Products
- Sino Biological Human cDNA Clone for MTHFD2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MTHFD2
- VectorBuilder custom plasmid, inducible vectors for MTHFD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTHFD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MTHFD2
-
ViGene Biosciences adenoviral particle packaged cDNA for MTHFD2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MTHFD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTHFD2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTHFD2 Gene
Localization for MTHFD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTHFD2 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 22664934 |
| GO:0005739 | mitochondrion | ISS | 8218174 |
| GO:0005759 | mitochondrial matrix | TAS | -- |
| GO:0005829 | NOT cytosol | IBA | -- |
Pathways & Interactions for MTHFD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | One carbon pool by folate | ||
| 2 | Metabolism of water-soluble vitamins and cofactors | ||
| 3 | Metabolism |
.37
|
|
| 4 | Glucose / Energy Metabolism | ||
| 5 | Folate Metabolism | ||
Pathways by source for MTHFD2 Gene
1 Cell Signaling Technology pathway for MTHFD2 Gene
5 BioSystems pathways for MTHFD2 Gene
4 Reactome pathways for MTHFD2 Gene
2 KEGG pathways for MTHFD2 Gene
Interacting Proteins for MTHFD2 Gene
Selected Interacting proteins:
P13995-MTDC_HUMAN
ENSP00000377617
for MTHFD2 Gene via
IID
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006730 | one-carbon metabolic process | IBA,IEA | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0009396 | folic acid-containing compound biosynthetic process | IEA | -- |
| GO:0046653 | tetrahydrofolate metabolic process | IDA | 8218174 |
| GO:0046655 | folic acid metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for MTHFD2 Gene
Drugs & Compounds for MTHFD2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate |
|
2800-34-2 |
|
|||
| 5,10-Methenyltetrahydrofolic acid |
|
7444-29-3 |
|
|||
| 5,10-Methylene-THF |
|
31690-11-6 |
|
|||
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| Hydrogen Ion |
|
|
Transcripts for MTHFD2 Gene
mRNA/cDNA for MTHFD2 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (570) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MTHFD2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MTHFD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTHFD2
- GenScript: Design CRISPR guide RNA sequences for MTHFD2
miRNA Products
- Search ViGene Biosciences for MTHFD2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MTHFD2
- Browse OriGene Inhibitory RNA Products For MTHFD2
-
ViGene Biosciences ready-to-package AAV shRNAs for MTHFD2 gene
Clone Products
- Sino Biological Human cDNA Clone for MTHFD2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MTHFD2
- VectorBuilder custom plasmid, inducible vectors for MTHFD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTHFD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: |
Expression for MTHFD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
- Trachea
- Neural Tube (Nervous System)
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
- NULL (Uncategorized)
This gene is overexpressed in Liver (48.5) and Breast (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTHFD2 Gene
NURSA nuclear receptor signaling pathways regulating expression of MTHFD2 Gene:
MTHFD2SOURCE GeneReport for Unigene cluster for MTHFD2 Gene:
Hs.469030Evidence on tissue expression from TISSUES for MTHFD2 Gene
- Nervous system(4.8)
- Liver(4.6)
- Intestine(4.4)
- Thyroid gland(4.2)
- Blood(3.4)
- Eye(3)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for MTHFD2
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTHFD2 Gene
Orthologs for MTHFD2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTHFD2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MTHFD2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MTHFD2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Mthfd2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mthfd2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | MTHFD2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mthfd2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mthfd2 35 |
|
ManyToMany | |
| LOC101886265 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004677 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Nmdmc 36 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ADE3 35 |
|
OneToMany | |
| barley (Hordeum vulgare) |
Liliopsida | Hv.8473 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.7067 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.3377 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.890 34 |
|
- Species where no ortholog for MTHFD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- worm (Caenorhabditis elegans)
Paralogs for MTHFD2 Gene
(4) SIMAP similar genes for MTHFD2 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for MTHFD2 Gene
Variants for MTHFD2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000372634 | -- | 74,209,471(+) | TGGTC(C/T)TGATC | intron-variant | |
| rs1001042753 | -- | 74,202,066(+) | ACTTC(A/G)GTATA | intron-variant | |
| rs1001105800 | -- | 74,212,389(+) | AGCCT(C/T)CCCAG | intron-variant | |
| rs1001138361 | -- | 74,211,683(+) | ACAAG(A/G)ATCTG | intron-variant | |
| rs1001409300 | -- | 74,208,327(+) | ATTAC(A/G)CCTTG | intron-variant |
Residual Variation Intolerance Score:
33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.14;
23.12% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MTHFD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MTHFD2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTHFD2 Gene
Disorders for MTHFD2 Gene
Relevant External Links for MTHFD2
No disorders were found for MTHFD2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTHFD2 Gene
Publications for MTHFD2 Gene
- Nucleotide sequence of the human NAD-dependent methylene tetrahydrofolate dehydrogenase-cyclohydrolase. (PMID: 2587219) Peri K.G. … Mackenzie R.E. (Nucleic Acids Res. 1989) 2 3 4 64
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
- A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
Products for MTHFD2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MTHFD2
- Search Origene for MassSpec and Protein Over-expression Lysates for MTHFD2
- Origene Custom Protein Services for MTHFD2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MTHFD2
- Browse OriGene Inhibitory RNA Products For MTHFD2
- OriGene qPCR primer pairs for MTHFD2
- OriGene CRISPR knockouts for MTHFD2
- OriGene ORF clones in human for MTHFD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MTHFD2
- GenScript: Next-day shipping cDNA ORF clone for MTHFD2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MTHFD2
- GenScript Custom Assay Services for MTHFD2
- GenScript Custom overexpressing Cell Line Services for MTHFD2
- GenScript: Design CRISPR guide RNA sequences for MTHFD2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MTHFD2
- Cell Signaling Technology (CST) Antibodies for MTHFD2 (MTHFD2)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for MTHFD2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for MTHFD2
- Novus Biologicals proteins and lysates for MTHFD2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for MTHFD2
- Addgene plasmids for MTHFD2
- antibodies-online Antibodies for MTHFD2: See all 35
- antibodies-online Kits for MTHFD2: See all 1
- antibodies-online Proteins for MTHFD2: See all 9
- Search antibodies-online for peptides
- GeneTex MTHFD2 antibody for MTHFD2
- Search GeneTex for Proteins for MTHFD2
- ViGene Biosciences adenoviral particle packaged cDNA for MTHFD2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MTHFD2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MTHFD2 gene
- Search ViGene Biosciences for MTHFD2
- Santa Cruz Biotechnology (SCBT) Antibodies for MTHFD2
- Search Santa Cruz Biotechnology (SCBT) for MTHFD2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MTHFD2
- Horizon Cell Lines for MTHFD2
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTHFD2
- VectorBuilder custom plasmid, inducible vectors for MTHFD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTHFD2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MTHFD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer