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Aliases for MTG2 Gene

Aliases for MTG2 Gene

  • Mitochondrial Ribosome-Associated GTPase 2 2 3
  • GTPBP5 3 4 6
  • ObgH1 3 4 6
  • GTP-Binding Protein 5 (Putative) 2 3
  • GTP Binding Protein 5 (Putative) 2 3
  • Protein Obg Homolog 1 3 4
  • GTP-Binding Protein 5 4
  • DJ1005F21.2 3

External Ids for MTG2 Gene

Previous HGNC Symbols for MTG2 Gene

  • GTPBP5

Previous GeneCards Identifiers for MTG2 Gene

  • GC20P060759

Summaries for MTG2 Gene

Entrez Gene Summary for MTG2 Gene

  • Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MTG2 Gene

MTG2 (Mitochondrial Ribosome-Associated GTPase 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding and magnesium ion binding. An important paralog of this gene is GTPBP10.

UniProtKB/Swiss-Prot for MTG2 Gene

  • Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTG2 Gene

Genomics for MTG2 Gene

Genomic Location for MTG2 Gene

Start:
62,183,025 bp from pter
End:
62,203,568 bp from pter
Size:
20,544 bases
Orientation:
Plus strand

Genomic View for MTG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTG2 Gene

No data available for Regulatory Elements for MTG2 Gene

Proteins for MTG2 Gene

  • Protein details for MTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4K7-MTG2_HUMAN
    Recommended name:
    Mitochondrial ribosome-associated GTPase 2
    Protein Accession:
    Q9H4K7
    Secondary Accessions:
    • A6NDR3
    • B4DR85
    • Q96I17
    • Q9NVG9
    • Q9UFR4

    Protein attributes for MTG2 Gene

    Size:
    406 amino acids
    Molecular mass:
    43955 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner
    SequenceCaution:
    • Sequence=BAA91783.1; Type=Erroneous termination; Positions=402; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTG2 Gene

Proteomics data for MTG2 Gene at MOPED

Post-translational modifications for MTG2 Gene

  • Ubiquitination at Lys123
  • Modification sites at PhosphoSitePlus

Other Protein References for MTG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTG2 Gene

Domains for MTG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4K7

UniProtKB/Swiss-Prot:

MTG2_HUMAN :
  • Q9H4K7
Domain:
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with MTG2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MTG2 Gene

Function for MTG2 Gene

Molecular function for MTG2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.

Gene Ontology (GO) - Molecular Function for MTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003924 GTPase activity IDA 23396448
GO:0005525 GTP binding IEA --
GO:0015093 ferrous iron transmembrane transporter activity --
genes like me logo Genes that share ontologies with MTG2: view

miRNA for MTG2 Gene

miRTarBase miRNAs that target MTG2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTG2 Gene

Localization for MTG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTG2 Gene

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Gene Ontology (GO) - Cellular Components for MTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IDA 23396448
GO:0005759 mitochondrial matrix IDA 23396448
GO:0005761 mitochondrial ribosome IDA 23396448
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with MTG2: view

No data available for Subcellular locations from COMPARTMENTS for MTG2 Gene

Pathways for MTG2 Gene

SuperPathways for MTG2 Gene

No Data Available

Interacting Proteins for MTG2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359859%0d%0a9606.ENSP00000363676%0d%0a9606.ENSP00000288937%0d%0a9606.ENSP00000225969%0d%0a9606.ENSP00000259469%0d%0a9606.ENSP00000341082%0d%0a
Selected Interacting proteins: Q9H4K7-MTG2_HUMAN ENSP00000359859 for MTG2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0008152 metabolic process IEA --
GO:0015684 ferrous iron transport --
GO:0042254 ribosome biogenesis IEA --
GO:0044065 regulation of respiratory system process IMP 23396448
genes like me logo Genes that share ontologies with MTG2: view

No data available for Pathways by source for MTG2 Gene

Transcripts for MTG2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MTG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - - - - - - - -
SP11: - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - -

Relevant External Links for MTG2 Gene

GeneLoc Exon Structure for
MTG2
ECgene alternative splicing isoforms for
MTG2

Expression for MTG2 Gene

mRNA expression in normal human tissues for MTG2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTG2 Gene

genes like me logo Genes that share expressions with MTG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTG2 Gene

Orthologs for MTG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MTG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTPBP5 35
  • 99.01 (n)
  • 98.52 (a)
GTPBP5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GTPBP5 35
  • 77.35 (n)
  • 79.18 (a)
GTPBP5 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTG2 35
  • 78.95 (n)
  • 78.42 (a)
MTG2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtpbp5 16
Mtg2 35
  • 78.93 (n)
  • 80.74 (a)
Mtg2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTG2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTG2 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtpbp5 35
  • 78.49 (n)
  • 81.77 (a)
chicken
(Gallus gallus)
Aves GTPBP5 35
  • 64.92 (n)
  • 68.32 (a)
MTG2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTG2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtg2 35
  • 65.08 (n)
  • 68.07 (a)
zebrafish
(Danio rerio)
Actinopterygii mtg2 35
  • 63.91 (n)
  • 65.44 (a)
mtg2 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009702 35
  • 53.11 (n)
  • 49.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13390 35
  • 49.54 (n)
  • 44 (a)
CG13390 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M01E5.2 35
  • 49.84 (n)
  • 51.42 (a)
M01E5.2 36
  • 45 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTG2 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB269 35
  • 45.1 (n)
  • 39.69 (a)
rice
(Oryza sativa)
Liliopsida Os07g0669200 35
  • 46.1 (n)
  • 40.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for MTG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTG2 Gene

ENSEMBL:
Gene Tree for MTG2 (if available)
TreeFam:
Gene Tree for MTG2 (if available)

Paralogs for MTG2 Gene

Paralogs for MTG2 Gene

Selected SIMAP similar genes for MTG2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MTG2: view

Variants for MTG2 Gene

Sequence variations from dbSNP and Humsavar for MTG2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1972 -- 62,200,876(+) CCCCA(C/T)GCAAT reference, synonymous-codon
rs1047154 -- 62,203,152(+) ATCTT(G/T)ATGCT downstream-variant-500B, utr-variant-3-prime, intron-variant
rs1047156 -- 62,203,169(+) GGGGA(G/T)GCTCA downstream-variant-500B, utr-variant-3-prime
rs1047164 -- 62,203,245(+) GATCT(A/G)GGCCT downstream-variant-500B, utr-variant-3-prime
rs1054885 -- 62,201,126(+) CCTGG(A/G)TGTGA utr-variant-3-prime

Relevant External Links for MTG2 Gene

HapMap Linkage Disequilibrium report
MTG2
Human Gene Mutation Database (HGMD)
MTG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTG2 Gene

Disorders for MTG2 Gene

No disorders were found for MTG2 Gene.

No data available for UniProtKB/Swiss-Prot for MTG2 Gene

Publications for MTG2 Gene

  1. Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures. (PMID: 17054726) Hirano Y. … Takeyasu K. (Genes Cells 2006) 2 3 4
  2. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. (PMID: 23396448) Kotani T. … Takeuchi N. (Nucleic Acids Res. 2013) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MTG2 Gene

Sources for MTG2 Gene

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