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MTG2 Gene

protein-coding   GIFtS: 41
GCID: GC20P060759

Mitochondrial Ribosome-Associated GTPase 2

(Previous names: GTP-binding protein 5 (putative), GTP binding protein 5...)
(Previous symbol: GTPBP5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitochondrial Ribosome-Associated GTPase 21 2     ObgH12 3
GTPBP51 2 3 5     OBGH13 5
GTP Binding Protein 5 (Putative)1 2     dJ1005F21.22
GTP-Binding Protein 5 (Putative)1 2     GTP-Binding Protein 53
Protein Obg Homolog 12 3     

External Ids:    HGNC: 162391   Entrez Gene: 261642   Ensembl: ENSG000001011817   OMIM: 6109195   UniProtKB: Q9H4K73   
ORGUL members:         

Export aliases for MTG2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTG2 Gene:
Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of
fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal
transduction (Hirano et al., 2006 (PubMed 17054726)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MTG2 Gene:
MTG2 (mitochondrial ribosome-associated GTPase 2) is a protein-coding gene. Diseases associated with MTG2 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include magnesium ion binding and GTP binding. An important paralog of this gene is GTPBP10.

UniProtKB/Swiss-Prot: MTG2_HUMAN, Q9H4K7
Function: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity.
Displays GTPase activity. Involved in the ribosome maturation process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MTG2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTG2 promoter sequence
   Search Chromatin IP Primers for MTG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

MTG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTG2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P060759:  view genomic region     (about GC identifiers)

Start:
60,758,081 bp from pter      End:
60,778,624 bp from pter
Size:
20,544 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTG2_HUMAN, Q9H4K7 (See protein sequence)
Recommended Name: Mitochondrial ribosome-associated GTPase 2  
Size: 406 amino acids; 43955 Da
Subunit: Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent
manner
Sequence caution: Sequence=BAA91783.1; Type=Erroneous termination; Positions=402; Note=Translated as Gln;
Secondary accessions: A6NDR3 Q96I17 Q9NVG9 Q9UFR4

Explore the universe of human proteins at neXtProt for MTG2: NX_Q9H4K7

Explore proteomics data for MTG2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys123
  • Modification sites at PhosphoSitePlus

  • See MTG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056481.1  
    ENSEMBL proteins: 
     ENSP00000435214   ENSP00000359859   ENSP00000414693   ENSP00000392267   ENSP00000445056  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR014100 GTP-bd_Obg/CgtA
     IPR005225 Small_GTP-bd_dom
     IPR006169 GTP1_OBG_dom
     IPR027417 P-loop_NTPase
     IPR006073 GTP_binding_domain

    Graphical View of Domain Structure for InterPro Entry Q9H4K7

    ProtoNet protein and cluster: Q9H4K7

    2 Blocks protein domains:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature


    UniProtKB/Swiss-Prot: MTG2_HUMAN, Q9H4K7
    Similarity: Belongs to the GTP1/OBG family
    Similarity: Contains 1 G (guanine nucleotide-binding) domain


    MTG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTG2_HUMAN, Q9H4K7
    Function: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity.
    Displays GTPase activity. Involved in the ribosome maturation process

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003924GTPase activity IDA--
    GO:0005525GTP binding IEA--
    GO:0015093ferrous iron transmembrane transporter activity ----
         
    MTG2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTG2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTG2
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    miRNA
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    miRTarBase miRNAs that target MTG2:
    hsa-mir-769-5p (MIRT039204)

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    SwitchGear 3'UTR luciferase reporter plasmidMTG2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTG2_HUMAN, Q9H4K7: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IDA--
    GO:0005759mitochondrial matrix IDA--
    GO:0005761mitochondrial ribosome IDA--

    MTG2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTG2
    Interactions:

        Search GeneGlobe Interaction Network for MTG2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for MTG2 (Q9H4K72, 3 ENSP000003598594) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261208 I2D: score=2 
    TAB1Q157502, 3MINT-8260119 I2D: score=2 
    MAPK1P284823I2D: score=5 
    ABCD2Q9UBJ23I2D: score=1 
    ANAPC2Q9UJX63I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA--
    GO:0007264small GTPase mediated signal transduction ----
    GO:0015684ferrous iron transport ----
    GO:0042254ribosome biogenesis IEA--
    GO:0044065regulation of respiratory system process IMP--

    MTG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTG2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTG2 gene: 
    NM_015666.3  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466933 ENST00000471352 ENST00000467101(uc011aad.2 uc011aae.2 uc011aaf.2)
    ENST00000370823(uc002yce.4 uc011aab.2 uc011aac.2) ENST00000448254
    ENST00000472005 ENST00000466099 ENST00000461411 ENST00000471962 ENST00000488748
    ENST00000436421 ENST00000536470
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MTG2
      QuantiFast Probe-based Assays in human, mouse, rat MTG2

    Selected AceView cDNA sequences (see all 207):

    AA962520 AI872069 BU857001 CF126007 NM_015666 AA854445 R94986 BF589592 
    CF124978 BM990316 AI985007 BG875811 AW135079 BE349005 AA626265 BU195889 
    CB150615 BM477460 AA372025 AI418210 BM559349 BG741702 CB127579 AI434936 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTG2 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12a · 12b
    SP1:                                -     -           -           -     -     -                                                                     
    SP2:                                -     -     -     -           -     -     -                                                                     
    SP3:        -     -     -           -     -     -     -           -     -     -                                                                     
    SP4:              -                 -     -     -     -           -     -     -                                                                     
    SP5:                                -     -     -     -           -                                                                                 


    ECgene alternative splicing isoforms for MTG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MTG2 Expression
    About this image

    MTG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTG2 Protein Expression
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MTG2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtpbp55
    Mtg21
    GTP binding protein 55
    mitochondrial ribosome associated GTPase 21
    78.93(n)1
    80.74(a)1
      2 (102.59 cM)5
    528561  NM_001083328.11  NP_001076797.11 
     1800705885 
    chicken
    (Gallus gallus)
    Aves GTPBP51 GTP binding protein 5 (putative) 64.92(n)
    68.32(a)
      419226  XM_417403.3  XP_417403.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTG26
    mitochondrial ribosome-associated GTPase 2
    63(a)
    1 ↔ 1
    4(150677372-150699512)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480559912   -- 74.28(n)    48055991 
    zebrafish
    (Danio rerio)
    Actinopterygii BM141631.12   -- 74.17(n)    BM141631.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133901 CG13390 49.54(n)
    44(a)
      34154  NM_135374.3  NP_609218.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M01E5.21 M01E5.2 49.84(n)
    51.42(a)
      173192  NM_060933.4  NP_493334.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTG26
    Putative GTPase, member of the Obg family; periphe...
    26(a)
    1 → many
    VIII(440377-441933) YHR168W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB2691 EMB269 45.1(n)
    39.69(a)
      831975  NM_121862.2  NP_197358.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g06692001 Os07g0669200 46.1(n)
    40.26(a)
      4344232  NM_001067121.1  NP_001060586.1 


    ENSEMBL Gene Tree for MTG2 (if available)
    TreeFam Gene Tree for MTG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTG2 gene
    GTPBP102  
    1 SIMAP similar gene for MTG2 using alignment to 5 protein entries:     MTG2_HUMAN (see all proteins):
    GTPBP10

    MTG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTG2 (see all 643)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30788701,2
    C--60758121(-) CTCCC-/CG    
       CTCCC
    GCACT
    1 -- int10--------
    rs121060731,2
    C--60758128(+) GGAGCG/TGGGAG 1 -- int10--------
    rs1460754521,2
    --60758142(+) GGAGCG/TTGGGC 1 -- int10--------
    rs1922493661,2
    C--60758148(+) TGGGCC/TTGGGG 1 -- int10--------
    rs1828117881,2
    C--60758345(+) TGCTCA/CCCGGT 1 -- int10--------
    rs1885530641,2
    --60758500(+) TTAAAC/TATTTT 1 -- int10--------
    rs1146331281,2
    F--60758537(+) GCACAA/GAACAA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs733074971,2
    C--60758562(+) CATTTG/AGATGA 1 -- int12Minor allele frequency- A:0.11WA 120
    rs1129377631,2
    C,F--60758564(+) TTTGGG/ATGATA 1 -- int11Minor allele frequency- A:0.00CSA 1
    rs739178301,2
    C--60758804(+) GGAGGA/GCCCAT 1 -- int14Minor allele frequency- G:0.13WA NA EA 360

    HapMap Linkage Disequilibrium report for MTG2 (60758081 - 60778624 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MTG2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTG2
    DNA2.0 Custom Variant and Variant Library Synthesis for MTG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610919    OMIM disorders: --

    6 diseases for MTG2:    
    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    malaria    esophagitis
    prostate cancer    prostatitis


    MTG2 for disorders           About GeneDecksing


    Export disorders for MTG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTG2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MTG2)
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    1. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. (PubMed id 23396448)1, 2, 3 Kotani T....Takeuchi N. (Nucleic Acids Res. 2013)
    2. Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures. (PubMed id 17054726)1, 2, 3 Hirano Y.... Takeyasu K. (Genes Cells 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. De novo deletion of chromosome 20q13.33 in a patient with tracheo-esophageal fistula, cardiac defects and genitourinary anomalies implicates GTPBP5 as a candidate gene. (PubMed id 21608104)1 Solomon B.D....Chandrasekharappa S.C. (Birth Defects Res. Part A Clin. Mol. Teratol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26164 HGNC: 16239 AceView: GTPBP5 Ensembl:ENSG00000101181 euGenes: HUgn26164
    ECgene: MTG2 H-InvDB: MTG2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTG2 gene:
    Search GeneIP for patents involving MTG2

    GeneCards and IP:
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