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Aliases for MTG2 Gene

Aliases for MTG2 Gene

  • Mitochondrial Ribosome Associated GTPase 2 2 3 5
  • Mitochondrial Ribosome-Associated GTPase 2 2 3
  • GTP Binding Protein 5 (Putative) 2 3
  • GTP-Binding Protein 5 3 4
  • Protein Obg Homolog 1 3 4
  • GTPBP5 3 4
  • ObgH1 3 4
  • GTP-Binding Protein 5 (Putative) 2
  • DJ1005F21.2 3

External Ids for MTG2 Gene

Previous HGNC Symbols for MTG2 Gene

  • GTPBP5

Previous GeneCards Identifiers for MTG2 Gene

  • GC20P060759

Summaries for MTG2 Gene

Entrez Gene Summary for MTG2 Gene

  • Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MTG2 Gene

MTG2 (Mitochondrial Ribosome Associated GTPase 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding and magnesium ion binding. An important paralog of this gene is GTPBP10.

UniProtKB/Swiss-Prot for MTG2 Gene

  • Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTG2 Gene

Genomics for MTG2 Gene

Regulatory Elements for MTG2 Gene

Enhancers for MTG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F062201 0.6 ENCODE 23.3 +18.7 18748 1.1 POLR2A GLIS1 MTG2 PSMA7 SS18L1 ADRM1 ENSG00000226332 LAMA5 MIR4758 OSBPL2 PIR52239 HRH3
GH20F062185 1 Ensembl ENCODE 15.2 +3.6 3564 3.2 ELF3 TBP ARID4B DMAP1 THRB ZNF48 RAD21 YY1 RARA SCRT2 MTG2 PSMA7 SS18L1 HRH3 PIR52239
GH20F062132 1 Ensembl ENCODE 11.4 -48.8 -48814 3.6 ELF3 MLX ARID4B ZNF48 ZSCAN9 RAD21 DNMT3B RARA YY1 ZNF143 MTG2 SS18L1 GC20M062135 PIR34643
GH20F062275 0.5 ENCODE 11 +93.9 93912 1.9 CTCF ZNF654 ZNF600 RAD21 LAMA5 MIR4758 HRH3 MTG2 LAMA5-AS1 CABLES2 GC20M062290 OSBPL2
GH20F062236 1.1 FANTOM5 ENCODE 10.5 +55.3 55297 4.0 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF143 FOS OSBPL2 MTG2 LAMA5-AS1 CABLES2 GATA5 GC20M062290
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MTG2 on UCSC Golden Path with GeneCards custom track

Promoters for MTG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000404022 175 2401 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MTG2 Gene

Chromosome:
20
Start:
62,183,025 bp from pter
End:
62,203,568 bp from pter
Size:
20,544 bases
Orientation:
Plus strand

Genomic View for MTG2 Gene

Genes around MTG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTG2 Gene

Proteins for MTG2 Gene

  • Protein details for MTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4K7-MTG2_HUMAN
    Recommended name:
    Mitochondrial ribosome-associated GTPase 2
    Protein Accession:
    Q9H4K7
    Secondary Accessions:
    • A6NDR3
    • B4DR85
    • Q96I17
    • Q9NVG9
    • Q9UFR4

    Protein attributes for MTG2 Gene

    Size:
    406 amino acids
    Molecular mass:
    43955 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner.
    SequenceCaution:
    • Sequence=BAA91783.1; Type=Erroneous termination; Positions=402; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTG2 Gene

Post-translational modifications for MTG2 Gene

  • Ubiquitination at Lys 123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTG2 Gene

Domains & Families for MTG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4K7

UniProtKB/Swiss-Prot:

MTG2_HUMAN :
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Domain:
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with MTG2: view

No data available for Gene Families for MTG2 Gene

Function for MTG2 Gene

Molecular function for MTG2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.

Gene Ontology (GO) - Molecular Function for MTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003924 GTPase activity IDA 23396448
GO:0005525 GTP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MTG2: view
genes like me logo Genes that share phenotypes with MTG2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTG2 Gene

Localization for MTG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTG2 Gene

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Gene Ontology (GO) - Cellular Components for MTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA,IDA 23396448
GO:0005759 mitochondrial matrix IDA 23396448
GO:0005761 mitochondrial ribosome IDA 23396448
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MTG2: view

No data available for Subcellular locations from COMPARTMENTS for MTG2 Gene

Pathways & Interactions for MTG2 Gene

SuperPathways for MTG2 Gene

No Data Available

Interacting Proteins for MTG2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359859%0d%0a9606.ENSP00000288937%0d%0a9606.ENSP00000363676%0d%0a9606.ENSP00000296102%0d%0a9606.ENSP00000359345%0d%0a9606.ENSP00000377486%0d%0a
Selected Interacting proteins: ENSP00000359859 Q9H4K7-MTG2_HUMAN for MTG2 Gene via STRING MINT IID

Gene Ontology (GO) - Biological Process for MTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0042254 ribosome biogenesis IEA --
GO:0044065 regulation of respiratory system process IMP 23396448
GO:0070129 regulation of mitochondrial translation IMP 23396448
genes like me logo Genes that share ontologies with MTG2: view

No data available for Pathways by source and SIGNOR curated interactions for MTG2 Gene

Drugs & Compounds for MTG2 Gene

(1) Drugs for MTG2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with MTG2: view

Transcripts for MTG2 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - - - - - - - -
SP11: - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - -

Relevant External Links for MTG2 Gene

GeneLoc Exon Structure for
MTG2
ECgene alternative splicing isoforms for
MTG2

Expression for MTG2 Gene

mRNA expression in normal human tissues for MTG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTG2 Gene

This gene is overexpressed in Lung (22.3), Esophagus (15.0), and Colon (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTG2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MTG2 Gene:

MTG2
genes like me logo Genes that share expression patterns with MTG2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MTG2 Gene

Orthologs for MTG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MTG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTPBP5 34 35
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia MTG2 34 35
  • 78.95 (n)
mouse
(Mus musculus)
Mammalia Mtg2 34 16 35
  • 78.93 (n)
rat
(Rattus norvegicus)
Mammalia Gtpbp5 34
  • 78.49 (n)
cow
(Bos Taurus)
Mammalia GTPBP5 34 35
  • 77.35 (n)
oppossum
(Monodelphis domestica)
Mammalia MTG2 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTG2 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTPBP5 34
  • 64.92 (n)
MTG2 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTG2 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtg2 34
  • 65.08 (n)
zebrafish
(Danio rerio)
Actinopterygii mtg2 34 35
  • 63.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009702 34
  • 53.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13390 34 35
  • 49.54 (n)
worm
(Caenorhabditis elegans)
Secernentea M01E5.2 34 35
  • 49.84 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTG2 35
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB269 34
  • 45.1 (n)
rice
(Oryza sativa)
Liliopsida Os07g0669200 34
  • 46.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToOne
Species where no ortholog for MTG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTG2 Gene

ENSEMBL:
Gene Tree for MTG2 (if available)
TreeFam:
Gene Tree for MTG2 (if available)

Paralogs for MTG2 Gene

Paralogs for MTG2 Gene

(1) SIMAP similar genes for MTG2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MTG2: view

Variants for MTG2 Gene

Sequence variations from dbSNP and Humsavar for MTG2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1047154 -- 62,203,152(+) ATCTT(G/T)ATGCT downstream-variant-500B, utr-variant-3-prime
rs1047156 -- 62,203,169(+) GGGGA(G/T)GCTCA downstream-variant-500B, utr-variant-3-prime
rs1047164 -- 62,203,245(+) GATCT(A/G)GGCCT downstream-variant-500B, utr-variant-3-prime
rs1054885 -- 62,201,126(+) CCTGG(A/G)TGTGA utr-variant-3-prime
rs1056885 -- 62,182,433(+) GTATA(A/G)ATTGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTG2 Gene

Variant ID Type Subtype PubMed ID
esv2665017 CNV deletion 23128226
esv3646285 CNV loss 21293372
nsv1160689 CNV deletion 26073780
nsv586484 CNV loss 21841781
nsv955149 CNV deletion 24416366

Variation tolerance for MTG2 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTG2 Gene

Human Gene Mutation Database (HGMD)
MTG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTG2 Gene

Disorders for MTG2 Gene

Relevant External Links for MTG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTG2

No disorders were found for MTG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTG2 Gene

Publications for MTG2 Gene

  1. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. (PMID: 23396448) Kotani T. … Takeuchi N. (Nucleic Acids Res. 2013) 2 3 4 64
  2. Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures. (PMID: 17054726) Hirano Y. … Takeyasu K. (Genes Cells 2006) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for MTG2 Gene

Sources for MTG2 Gene

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