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Aliases for MTG2 Gene

Aliases for MTG2 Gene

  • Mitochondrial Ribosome Associated GTPase 2 2 3
  • Mitochondrial Ribosome-Associated GTPase 2 2 5
  • GTP-Binding Protein 5 (Putative) 2 3
  • GTP Binding Protein 5 (Putative) 2 3
  • Protein Obg Homolog 1 3 4
  • GTPBP5 3 4
  • ObgH1 3 4
  • GTP-Binding Protein 5 4
  • DJ1005F21.2 3

External Ids for MTG2 Gene

Previous HGNC Symbols for MTG2 Gene

  • GTPBP5

Previous GeneCards Identifiers for MTG2 Gene

  • GC20P060759

Summaries for MTG2 Gene

Entrez Gene Summary for MTG2 Gene

  • Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MTG2 Gene

MTG2 (Mitochondrial Ribosome Associated GTPase 2) is a Protein Coding gene. Diseases associated with MTG2 include Esophageal Disease. GO annotations related to this gene include GTP binding and magnesium ion binding. An important paralog of this gene is GTPBP10.

UniProtKB/Swiss-Prot for MTG2 Gene

  • Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTG2 Gene

Genomics for MTG2 Gene

Regulatory Elements for MTG2 Gene

Enhancers for MTG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTG2 on UCSC Golden Path with GeneCards custom track

Promoters for MTG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTG2 Gene

62,183,025 bp from pter
62,203,568 bp from pter
20,544 bases
Plus strand

Genomic View for MTG2 Gene

Genes around MTG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTG2 Gene

Proteins for MTG2 Gene

  • Protein details for MTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial ribosome-associated GTPase 2
    Protein Accession:
    Secondary Accessions:
    • A6NDR3
    • B4DR85
    • Q96I17
    • Q9NVG9
    • Q9UFR4

    Protein attributes for MTG2 Gene

    406 amino acids
    Molecular mass:
    43955 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner.
    • Sequence=BAA91783.1; Type=Erroneous termination; Positions=402; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTG2 Gene


neXtProt entry for MTG2 Gene

Proteomics data for MTG2 Gene at MOPED

Post-translational modifications for MTG2 Gene

  • Ubiquitination at Lys 123
  • Modification sites at PhosphoSitePlus

Other Protein References for MTG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTG2 Gene

Domains & Families for MTG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with MTG2: view

No data available for Gene Families for MTG2 Gene

Function for MTG2 Gene

Molecular function for MTG2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.
genes like me logo Genes that share phenotypes with MTG2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTG2 Gene

Localization for MTG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTG2 Gene

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Gene Ontology (GO) - Cellular Components for MTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005761 mitochondrial ribosome IDA 23396448
genes like me logo Genes that share ontologies with MTG2: view

No data available for Subcellular locations from COMPARTMENTS for MTG2 Gene

Pathways & Interactions for MTG2 Gene

SuperPathways for MTG2 Gene

No Data Available

Interacting Proteins for MTG2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: Q9H4K7-MTG2_HUMAN ENSP00000359859 for MTG2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MTG2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTG2 Gene

Drugs & Compounds for MTG2 Gene

(1) Drugs for MTG2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with MTG2: view

Transcripts for MTG2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MTG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - - - - - - - -
SP11: - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - -

Relevant External Links for MTG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTG2 Gene

mRNA expression in normal human tissues for MTG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTG2 Gene

This gene is overexpressed in Lung (22.3), Esophagus (15.0), and Colon (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTG2 Gene

genes like me logo Genes that share expression patterns with MTG2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MTG2 Gene

Orthologs for MTG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MTG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GTPBP5 35
  • 77.35 (n)
  • 79.18 (a)
  • 65 (a)
(Canis familiaris)
Mammalia MTG2 35
  • 78.95 (n)
  • 78.42 (a)
MTG2 36
  • 77 (a)
(Mus musculus)
Mammalia Mtg2 35
  • 78.93 (n)
  • 80.74 (a)
Mtg2 16
Mtg2 36
  • 80 (a)
(Pan troglodytes)
Mammalia GTPBP5 35
  • 99.01 (n)
  • 98.52 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Gtpbp5 35
  • 78.49 (n)
  • 81.77 (a)
(Monodelphis domestica)
Mammalia MTG2 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia MTG2 36
  • 67 (a)
(Gallus gallus)
Aves GTPBP5 35
  • 64.92 (n)
  • 68.32 (a)
MTG2 36
  • 62 (a)
(Anolis carolinensis)
Reptilia MTG2 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtg2 35
  • 65.08 (n)
  • 68.07 (a)
(Danio rerio)
Actinopterygii mtg2 35
  • 63.91 (n)
  • 65.44 (a)
mtg2 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009702 35
  • 53.11 (n)
  • 49.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13390 35
  • 49.54 (n)
  • 44 (a)
CG13390 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea M01E5.2 35
  • 49.84 (n)
  • 51.42 (a)
M01E5.2 36
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTG2 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB269 35
  • 45.1 (n)
  • 39.69 (a)
(Oryza sativa)
Liliopsida Os07g0669200 35
  • 46.1 (n)
  • 40.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for MTG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTG2 Gene

Gene Tree for MTG2 (if available)
Gene Tree for MTG2 (if available)

Paralogs for MTG2 Gene

Paralogs for MTG2 Gene

(1) SIMAP similar genes for MTG2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MTG2: view

Variants for MTG2 Gene

Sequence variations from dbSNP and Humsavar for MTG2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6062133 - 62,193,559(+) CGGTC(A/C/G/T)GCCGT reference, missense
rs11700220 - 62,195,875(+) CTTCC(A/G)CAGTG reference, missense
rs35693261 - 62,200,866(-) GCCTC(A/G)CAGAC downstream-variant-500B, reference, missense
rs1972 -- 62,200,876(+) CCCCA(C/T)GCAAT downstream-variant-500B, reference, synonymous-codon
rs1047154 -- 62,203,152(+) ATCTT(G/T)ATGCT downstream-variant-500B, utr-variant-3-prime

Variation tolerance for MTG2 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTG2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTG2 Gene

Disorders for MTG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MTG2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
esophageal disease
  • esophageal ulcer
- elite association - COSMIC cancer census association via MalaCards
Search MTG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MTG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MTG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTG2 Gene

Publications for MTG2 Gene

  1. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. (PMID: 23396448) Kotani T. … Takeuchi N. (Nucleic Acids Res. 2013) 2 3 4 67
  2. Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures. (PMID: 17054726) Hirano Y. … Takeyasu K. (Genes Cells 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. De novo deletion of chromosome 20q13.33 in a patient with tracheo-esophageal fistula, cardiac defects and genitourinary anomalies implicates GTPBP5 as a candidate gene. (PMID: 21608104) Solomon B.D. … Chandrasekharappa S.C. (Birth Defects Res. Part A Clin. Mol. Teratol. 2011) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for MTG2 Gene

Sources for MTG2 Gene