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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTG1 Gene

protein-coding   GIFtS: 51
GCID: GC10P135207

Mitochondrial Ribosome-Associated GTPase 1

(Previous names: GTP-binding protein 7, GTP-binding protein 7 (putative),...)
(Previous symbol: GTPBP7)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosome-Associated GTPase 11 2     Mitochondrial GTPase 1 Homolog (S. Cerevisiae)1
GTPBP71 2 3     GTP2
GTP-Binding Protein 7 (Putative)1 2     RP11-108K14.22
GTP-Binding Protein 71 3     Mitochondrial GTPase 1 Homolog2

External Ids:    HGNC: 321591   Entrez Gene: 921702   Ensembl: ENSG000001488247   UniProtKB: Q9BT173   

Export aliases for MTG1 gene to outside databases

Previous GC identifers: GC10P135099 GC10P135057 GC10P128751


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MTG1 Gene: 
MTG1 (mitochondrial ribosome-associated GTPase 1) is a protein-coding gene. Diseases associated with MTG1 include pneumonia. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ENSG00000254536.

UniProtKB/Swiss-Prot: MTG1_HUMAN, Q9BT17
Function: Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)

Gene Wiki entry for MTG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTG1 gene promoter:
         Max1   Max   AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

MTG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTG1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P135207:  view genomic region     (about GC identifiers)

Start:
135,207,598 bp from pter      End:
135,234,811 bp from pter
Size:
27,214 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTG1_HUMAN, Q9BT17 (See protein sequence)
Recommended Name: Mitochondrial GTPase 1 precursor  
Size: 334 amino acids; 37237 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAH04409.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH35721.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5VWX8 Q6PIY9 Q8IYJ4 Q8NC48 Q9BVU8
Alternative splicing: 2 isoforms:  Q9BT17-1   Q9BT17-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTG1: NX_Q9BT17

Explore proteomics data for MTG1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BT17

  • MTG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTG1 Protein Expression
    REFSEQ proteins: NP_612393.2  
    ENSEMBL proteins: 
     ENSP00000475596   ENSP00000323047   ENSP00000393480  

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    Cloud-Clone Corp. Proteins for MTG1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IDA--
    GO:0005759mitochondrial matrix IDA--

    MTG1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR016478 GTPase_MTG1
     IPR027417 P-loop_NTPase
     IPR006073 GTP_binding_domain
     IPR023179 GTP-bd_ortho_bundle
     IPR019991 GTP-bd_ribosome_bgen_YlqF

    Graphical View of Domain Structure for InterPro Entry Q9BT17

    ProtoNet protein and cluster: Q9BT17

    2 Blocks protein domains:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature


    UniProtKB/Swiss-Prot: MTG1_HUMAN, Q9BT17
    Similarity: Belongs to the MMR1/HSR1 GTP-binding protein family. MTG1 subfamily
    Similarity: Contains 1 G (guanine nucleotide-binding) domain


    MTG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTG1_HUMAN, Q9BT17
    Function: Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA--
    GO:0005525GTP binding IEA--
         
    MTG1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MTG1:
     Decreased viability with pacli  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MTG1 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTG1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/262 Interacting proteins for MTG1 (Q9BT171, 2, 3 ENSP000003230474) via UniProtKB, MINT, STRING, and/or I2D (see all 262)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STRN4Q9NRL32, 3MINT-65609 I2D: score=4 
    PRNPP041561, 3EBI-2602570,EBI-977302 I2D: score=1 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    CTSDP073393I2D: score=5 
    DDX55Q8NHQ93I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA--
    GO:0042254ribosome biogenesis IBA--
    GO:0044065regulation of respiratory system process IMP--
    GO:0070129regulation of mitochondrial translation IMP--

    MTG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MTG1

    1 HMDB Compound for MTG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about MTG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTG1 gene: 
    NM_138384.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477902 ENST00000317502(uc001lnd.3 uc010qve.2) ENST00000432508
    ENST00000460848 ENST00000495014 ENST00000498790 ENST00000473735 ENST00000492266

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
    Products:
         
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    24/327 AceView cDNA sequences (see all 327):

    NM_152911 BU737672 BQ709341 BM754583 CR616914 AW294364 AA502309 AW297100 
    CB123707 BM714035 CF272242 BQ919866 AA351036 CB215673 AA749407 AI973043 
    BI753957 CR592090 BF057699 AA404221 CF131152 BU849806 AI355435 NM_207126 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MTG1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                -     -     -                                         -     -     -           -                                 
    SP2:                                      -                                               -     -     -                                             
    SP3:                                -     -     -                                         -     -     -                                             
    SP4:                                -     -     -                                               -     -                                             
    SP5:                                -     -     -                                                                                                   


    ECgene alternative splicing isoforms for MTG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGGTTCTC
    MTG1 Expression
    About this image


    See MTG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTG1
        SABiosciences Custom PCR Arrays for MTG1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MTG1 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtg11 , 5 mitochondrial GTPase 1 homolog (S. cerevisiae)1, 5 79.77(n)1
    81.73(a)1
      7 (85.16 cM)5
    2125081  NM_199301.21  NP_955005.21 
     1401375645 
    chicken
    (Gallus gallus)
    Aves MTG11 mitochondrial GTPase 1 homolog (S. cerevisiae) 67.1(n)
    63.93(a)
      791224  XM_003641467.1  XP_003641515.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Mitochondrial GTPase 1
    64(a)
    1 → many
    GL343297.1(1191702-1205184)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157052 Xenopus laevis transcribed sequence with weak similarity more 75.43(n)    BX846067.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gtpbpl2 GTP binding protein like 73.46(n)   386703  CK025441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG171411 CG17141 54.3(n)
    47.68(a)
      42697  NM_142837.2  NP_651094.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y67D2.41 Protein Y67D2.4 47.21(n)
    38.03(a)
      175306  NM_001129266.1  NP_001122738.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTG1(YMR097C)4
    MTG11
    Putative GTPase peripheral to the mitochondrial inner more4
    Mtg1p1
    45.42(n)1
    35.46(a)1
      13(460527-459424)4
    8551221, 4  NP_013815.11, 4 


    ENSEMBL Gene Tree for MTG1 (if available)
    TreeFam Gene Tree for MTG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTG1 gene
    ENSG000002545362  

    MTG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/827 SNPs in MTG1 are shown (see all 827)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162919291,2
    C,F--135205781(+) GGGCAG/ATGCTG 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs748500741,2
    C,F--135205934(+) CCCACC/TCTCCC 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1462405601,2
    --135206010(+) TCTGGA/GGACAC 1 -- us2k10--------
    rs579657181,2
    C,F--135206228(+) GGAGGG/AGGCTT 1 -- us2k12Minor allele frequency- A:0.17CSA WA 119
    rs113186921,2
    C--135206266(+) GACTG-/CCCCCA 1 -- us2k12Minor allele frequency- C:0.00NA CSA 4
    rs1907938741,2
    --135206331(+) TCATGC/TCCAAA 1 -- us2k10--------
    rs48387401,2
    C,F,A,H--135206354(+) TAGGCA/GTTAGG 1 -- us2k133Minor allele frequency- G:0.24NS EA NA WA CSA 3195
    rs101599221,2
    C--135206394(+) ATGGCA/CATATT 1 -- us2k10--------
    rs1423225331,2
    C--135206427(+) GTTTGA/GTATTT 1 -- us2k10--------
    rs1839806531,2
    --135206577(+) CATCTC/GTACTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTG1 (135207598 - 135234811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/32 variations for MTG1 (see all 32):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    dgv891n71CNV Loss21882294
    nsv467509CNV Loss19166990
    nsv527785CNV Loss19592680
    dgv880n71CNV Loss21882294
    nsv832040CNV Loss17160897
    dgv889n71CNV Loss21882294
    nsv470980CNV Loss18288195
    dgv882n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for MTG1:    About MalaCards
    pneumonia    


    MTG1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTG1
    Human Genome Epidemiology (HuGE) Navigator: MTG1 (1 document)

    Export disorders for MTG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTG1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MTG1)
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    1. MTG1 codes for a conserved protein required for mitochondrial translation. (PubMed id 12808030)1, 2, 3 Barrientos A.... Tzagoloff A. (2003)
    2. Human G-proteins, ObgH1 and Mtg1, associate with the l arge mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. (PubMed id 23396448)1, 3 Kotani T....Takeuchi N. (2013)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    9. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92170 HGNC: 32159 AceView: SprnandPAOX Ensembl:ENSG00000148824 euGenes: HUgn92170
    ECgene: MTG1 H-InvDB: MTG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTG1 gene:
    Search GeneIP for patents involving MTG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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