MTG1 Gene
protein-coding GIFtS: 45
GCID: GC10P135207
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mitochondrial GTPase 1 homolog (S. cerevisiae)(Previous names: GTP-binding protein 7, GTP-binding protein 7 (putative)...)
(Previous symbol: GTPBP7)
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Aliases
for MTG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial GTPase 1 Homolog (S. Cerevisiae)1 2 | | GTP2 | | GTPBP71 2 3 | | RP11-108K14.22 | | GTP-Binding Protein 7 (Putative)1 2 | | Mitochondrial GTPase 12 | | GTP-Binding Protein 71 3 | | |
Export aliases for MTG1 gene to outside databasesPrevious GC identifers: GC10P135099 GC10P135057 GC10P128751 |
Summaries
for MTG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MTG1_HUMAN, Q9BT17Function: Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)
Gene Wiki entry for MTG1
|
Genomic Views
for MTG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008818.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTG1 gene promoter:
Max1 Max AP-1 ATF-2 c-Jun c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3MTG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P135207: view genomic region
(about GC identifiers)
Start:
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135,204,338 bp from pter |
End:
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135,234,174 bp from pter |
Size:
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29,837 bases |
Orientation:
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plus strand |
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Proteins
for MTG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTG1_HUMAN, Q9BT17 (See
protein sequence)Recommended Name: Mitochondrial GTPase 1 precursor Size: 334 amino acids; 37237 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAH04409.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH35721.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5VWX8 Q6PIY9 Q8IYJ4 Q8NC48 Q9BVU8Alternative splicing: 2 isoforms: Q9BT17-1 Q9BT17-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MTG1: NX_Q9BT17
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BT17
MTG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612393.2
ENSEMBL proteins: ENSP00000436767
Human Recombinant Protein Products for MTG1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MTG1 for ontologies About GeneDecksing
MTG1 Antibody Products:
Assay Products for MTG1: |
Protein
Domains /
Families
for MTG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTG1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BT17ProtoNet protein and cluster: Q9BT17 2 Blocks protein families: IPB002917 GTP-binding protein IPB006073 GTP1/OBG GTP-binding protein family signature
UniProtKB/Swiss-Prot: MTG1_HUMAN, Q9BT17Similarity: Belongs to the MMR1/HSR1 GTP-binding protein family. MTG1 subfamilySimilarity: Contains 1 G (guanine nucleotide-binding) domain |
Function
for MTG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MTG1_HUMAN, Q9BT17Function: Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MTG1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for MTG1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTG1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTG1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MTG1 (NM_138384) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTG1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTG1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTG1 |
|
Pathways & Interactions
for MTG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTG1
5/245 Interacting proteins for MTG1 (Q9BT171, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 245)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006184 | GTP catabolic process |
IBA | -- | | GO:0042254 | ribosome biogenesis |
IBA | -- |
MTG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTG1
1 HMDB Compound for MTG1 About this table
Search CenterWatch for drugs/clinical trials and news about MTG1
|
Transcripts
for MTG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTG1 gene: NM_138384.2 Unigene Cluster for MTG1: Mitochondrial GTPase 1 homolog (S. cerevisiae) Hs.501578 [show with all ESTs]Unigene Representative Sequence: AK0958721 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000468317
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTG1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTG1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MTG1 (NM_138384) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTG1 |
Additional cDNA sequence: AK095872.1 AK125012.1 AK292515.1 AK293988.1 AK308997.1 BC000920.2 BC004409.1 BC026039.1 BC026725.1 BC035721.1 22 DOTS entries: DT.446844 DT.417386 DT.100811551 DT.100811548 DT.100811544 DT.100720809 DT.101984656 DT.100811543 DT.100811549 DT.109218 DT.91967323 DT.100037112 DT.91707724 DT.100811545 DT.100811546 DT.417384 DT.75196066 DT.91707721 DT.95225971 DT.97858940 DT.97858942 DT.87016111 24/327 AceView cDNA sequences (see all 327): NM_207128 BM714035 AI356090 CB123707 BU849806 BF057699 NM_152911 BM754583 AI698394 AA701889 BX398131 AA404221 NM_207125 CB215673 CF131152 AA393552 AW297100 AI682389 AI621125 CR592090 BQ709341 BQ708770 CR616914 BU146909
GeneLoc Exon Structure
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Expression
for MTG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGGTTCTC
About this image
See MTG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTG1
SOURCE GeneReport for Unigene cluster: Hs.501578
SABiosciences Custom PCR Arrays for MTG1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTG1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTG1 |
Orthologs
for MTG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MTG1 gene from 9/36 species (see all 36) About this table
ENSEMBL Gene Tree for MTG1 (if available)
TreeFam Gene Tree for MTG1 (if available) |
Paralogs
for MTG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MTG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTG1 (135204338 - 135234174 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 26 variations for MTG1
15/22 CNVs (see all 22): 29878 2896 5270 8673 5272 2162 53842 48474 5273 29601 48475 3829 4724 34537 8671
4 Indels: 85556 85557 75453 34330 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTG1 |
|
Disorders
/ Diseases
for MTG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTG1 for disorders About GeneDecksing
2  diseases for MTG1: About MalaCardspneumonia malaria
Human Genome Epidemiology (HuGE) Navigator: MTG1 (1 document)
Export disorders for MTG1 gene to outside databases
|
Publications
for MTG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTG1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MTG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MTG1 codes for a conserved protein required for mitochondrial translation. (PubMed id 12808030)1, 2, 3 Barrientos A.... Tzagoloff A. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
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External Searches for MTG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTG1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MTG1 gene:
Search GeneIP for patents involving MTG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTG1 | | | OriGene Protein Over-expression Lysate for MTG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for MTG1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MTG1 | | OriGene Custom Protein Services for MTG1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTG1 |
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| | | | Search Tocris compounds for MTG1 |
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 | | | MTG1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTG1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MTG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTG1 |
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