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Aliases for MTG1 Gene

Aliases for MTG1 Gene

  • Mitochondrial Ribosome-Associated GTPase 1 2 3
  • GTP-Binding Protein 7 (Putative) 2 3
  • GTP-Binding Protein 7 2 4
  • GTPBP7 3 4
  • Mitochondrial GTPase 1 Homolog (S. Cerevisiae) 2
  • Mitochondrial GTPase 1 Homolog 3
  • Mitochondrial GTPase 1 4
  • CBFA2T3 6
  • MTGR2 6
  • MTG16 6
  • GTP 3

External Ids for MTG1 Gene

Previous HGNC Symbols for MTG1 Gene

  • GTPBP7

Previous GeneCards Identifiers for MTG1 Gene

  • GC10P135099
  • GC10P135057
  • GC10P135207
  • GC10P128751

Summaries for MTG1 Gene

GeneCards Summary for MTG1 Gene

MTG1 (Mitochondrial Ribosome-Associated GTPase 1) is a Protein Coding gene. Among its related pathways are ErbB4 signaling events. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ENSG00000254536.

UniProtKB/Swiss-Prot for MTG1 Gene

  • Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

Gene Wiki entry for MTG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTG1 Gene

Genomics for MTG1 Gene

Regulatory Elements for MTG1 Gene

Genomic Location for MTG1 Gene

133,394,094 bp from pter
133,421,307 bp from pter
27,214 bases
Plus strand

Genomic View for MTG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTG1 Gene

Proteins for MTG1 Gene

  • Protein details for MTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial ribosome-associated GTPase 1
    Protein Accession:
    Secondary Accessions:
    • Q5VWX8
    • Q6PIY9
    • Q8IYJ4
    • Q8NC48
    • Q9BVU8

    Protein attributes for MTG1 Gene

    334 amino acids
    Molecular mass:
    37237 Da
    Quaternary structure:
    • Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner
    • Sequence=AAH04409.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH35721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTG1 Gene


neXtProt entry for MTG1 Gene

Proteomics data for MTG1 Gene at MOPED

Post-translational modifications for MTG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTG1 Gene

Domains for MTG1 Gene

Suggested Antigen Peptide Sequences for MTG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BT17
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
genes like me logo Genes that share domains with MTG1: view

No data available for Gene Families for MTG1 Gene

Function for MTG1 Gene

Molecular function for MTG1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

Gene Ontology (GO) - Molecular Function for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 23396448
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with MTG1: view
genes like me logo Genes that share phenotypes with MTG1: view

Animal Model Products

miRNA for MTG1 Gene

miRTarBase miRNAs that target MTG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTG1 Gene

Localization for MTG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTG1 Gene

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

Jensen Localization Image for MTG1 Gene COMPARTMENTS Subcellular localization image for MTG1 gene
Compartment Confidence
mitochondrion 5
nucleus 4

Gene Ontology (GO) - Cellular Components for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IDA 23396448
GO:0005759 mitochondrial matrix IDA 23396448
GO:0005761 mitochondrial ribosome IDA 23396448
genes like me logo Genes that share ontologies with MTG1: view

Pathways for MTG1 Gene

SuperPathways for MTG1 Gene

Superpath Contained pathways
1 ErbB4 signaling events
genes like me logo Genes that share pathways with MTG1: view

Pathways by source for MTG1 Gene

1 BioSystems pathway for MTG1 Gene

Gene Ontology (GO) - Biological Process for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0008152 metabolic process IDA 23396448
GO:0042254 ribosome biogenesis --
GO:0044065 regulation of respiratory system process IMP 23396448
GO:0070129 regulation of mitochondrial translation IMP 23396448
genes like me logo Genes that share ontologies with MTG1: view

Compounds for MTG1 Gene

(1) HMDB Compounds for MTG1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with MTG1: view

Transcripts for MTG1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTG1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - -
SP7: -
SP8: - - -

Relevant External Links for MTG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTG1 Gene

mRNA expression in normal human tissues for MTG1 Gene

Protein differential expression in normal tissues for MTG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Kidney (15.2), and Ovary (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTG1 Gene

genes like me logo Genes that share expressions with MTG1: view

Expression partners for MTG1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTG1 Gene

Orthologs for MTG1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MTG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MTG1 35
  • 85.94 (n)
  • 84.34 (a)
MTG1 36
  • 84 (a)
(Mus musculus)
Mammalia Mtg1 35
  • 79.77 (n)
  • 81.73 (a)
Mtg1 16
Mtg1 36
  • 81 (a)
(Pan troglodytes)
Mammalia MTG1 35
  • 99.4 (n)
  • 98.8 (a)
MTG1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mtg1 35
  • 81.11 (n)
  • 83.9 (a)
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
-- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
(Gallus gallus)
Aves MTG1 35
  • 67.1 (n)
  • 63.93 (a)
MTG1 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtg1 35
  • 66.67 (n)
  • 68.95 (a)
Str.15410 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15705 35
(Danio rerio)
Actinopterygii gtpbpl 35
  • 61.02 (n)
  • 61.86 (a)
gtpbpl 35
gtpbpl 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13992 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004736 35
  • 51.31 (n)
  • 48.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17141 35
  • 54.3 (n)
  • 47.68 (a)
CG17141 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea Y67D2.4 35
  • 47.21 (n)
  • 38.03 (a)
Y67D2.4 36
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL048W 35
  • 43.46 (n)
  • 30.37 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02904g 35
  • 41.49 (n)
  • 31.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTG1 35
  • 44.25 (n)
  • 33.45 (a)
MTG1 36
  • 26 (a)
MTG1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU02123 35
  • 45.32 (n)
  • 33.66 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mtg1 35
  • 42.09 (n)
  • 36.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for MTG1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTG1 Gene

Gene Tree for MTG1 (if available)
Gene Tree for MTG1 (if available)

Paralogs for MTG1 Gene

Paralogs for MTG1 Gene

genes like me logo Genes that share paralogs with MTG1: view

Variants for MTG1 Gene

Sequence variations from dbSNP and Humsavar for MTG1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1132347 -- 133,395,741(+) CTGAA(C/G)CTGGT missense, reference
rs2243619 -- 133,419,430(+) GGCCG(C/T)GCGGT intron-variant
rs2252619 -- 133,396,559(+) GGCAG(A/C)AAGCC intron-variant
rs2252852 -- 133,398,388(-) AGTCT(C/T)GGCTC intron-variant
rs2253097 -- 133,399,962(+) CCGAG(A/G)CGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTG1 Gene

Variant ID Type Subtype PubMed ID
nsv528260 CNV Loss 19592680
dgv328e1 CNV Complex 17122850
dgv880n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
essv20368 CNV CNV 17122850
nsv428243 CNV Gain 18775914
dgv3e196 CNV Duplication 17116639
esv2750853 CNV Gain 17911159
dgv889n71 CNV Loss 21882294
nsv832040 CNV Loss 17160897
nsv467509 CNV Loss 19166990
nsv896316 CNV Gain 21882294
nsv527785 CNV Loss 19592680
nsv470981 CNV Gain 18288195
nsv896317 CNV Loss 21882294
dgv35e55 CNV Gain 17911159
dgv329e1 CNV Complex 17122850
nsv7631 CNV Loss 18451855
dgv123n27 CNV Gain 19166990
nsv832041 CNV Gain 17160897
nsv896318 CNV Gain 21882294
dgv890n71 CNV Gain 21882294
nsv517180 CNV Gain+Loss 19592680
dgv124n27 CNV Gain 19166990
dgv125n27 CNV Gain 19166990
dgv891n71 CNV Loss 21882294
nsv896321 CNV Gain 21882294
nsv469597 CNV Gain 16826518
nsv514545 CNV Gain 21397061

Relevant External Links for MTG1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTG1 Gene

Disorders for MTG1 Gene

Relevant External Links for MTG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MTG1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MTG1 Gene

Publications for MTG1 Gene

  1. MTG1 codes for a conserved protein required for mitochondrial translation. (PMID: 12808030) Barrientos A. … Tzagoloff A. (Mol. Biol. Cell 2003) 2 3 4
  2. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. (PMID: 23396448) Kotani T. … Takeuchi N. (Nucleic Acids Res. 2013) 2 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for MTG1 Gene

Sources for MTG1 Gene

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