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Aliases for MTG1 Gene

Aliases for MTG1 Gene

  • Mitochondrial Ribosome Associated GTPase 1 2 3 5
  • Mitochondrial Ribosome-Associated GTPase 1 2 3
  • GTP-Binding Protein 7 (Putative) 2 3
  • GTP-Binding Protein 7 2 4
  • GTPBP7 3 4
  • Mitochondrial GTPase 1 Homolog (S. Cerevisiae) 2
  • Mitochondrial GTPase 1 Homolog 3
  • Mitochondrial GTPase 1 4
  • GTP 3

External Ids for MTG1 Gene

Previous HGNC Symbols for MTG1 Gene

  • GTPBP7

Previous GeneCards Identifiers for MTG1 Gene

  • GC10P135099
  • GC10P135057
  • GC10P135207
  • GC10P128751

Summaries for MTG1 Gene

GeneCards Summary for MTG1 Gene

MTG1 (Mitochondrial Ribosome Associated GTPase 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ENSG00000254536.

UniProtKB/Swiss-Prot for MTG1 Gene

  • Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

Gene Wiki entry for MTG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTG1 Gene

Genomics for MTG1 Gene

Regulatory Elements for MTG1 Gene

Enhancers for MTG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G133387 1.6 FANTOM5 Ensembl ENCODE 8.2 -3.7 -3651 5.0 HDGF PKNOX1 ARNT YBX1 YY1 ZNF143 ZNF263 SP3 NFYC JUNB ENSG00000235245 TUBGCP2 SCART1 PAOX MTG1 ECHS1 CFAP46 ENSG00000254536
GH10G133334 1.2 Ensembl ENCODE 4.8 -58.3 -58333 2.9 ATF1 SIN3A GLI4 GLIS2 KLF7 ZNF263 SP3 ZNF518A RFX3 GLIS1 SCART1 ECHS1 TUBGCP2 PAOX VENTX MTG1 FUOM CALY GC10M133326
GH10G133393 1.1 ENCODE 0.7 +0.6 562 2.4 HDGF HNRNPUL1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SCART1 ENSG00000235245 PAOX MTG1 SPRN
GH10G133400 0.4 ENCODE 0.4 +7.1 7080 1.5 JUNB STAT3 SCART1 MTG1 SPRN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTG1 on UCSC Golden Path with GeneCards custom track

Promoters for MTG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MTG1 Gene

133,394,094 bp from pter
133,421,307 bp from pter
27,214 bases
Plus strand

Genomic View for MTG1 Gene

Genes around MTG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTG1 Gene

Proteins for MTG1 Gene

  • Protein details for MTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial ribosome-associated GTPase 1
    Protein Accession:
    Secondary Accessions:
    • Q5VWX8
    • Q6PIY9
    • Q8IYJ4
    • Q8NC48
    • Q9BVU8

    Protein attributes for MTG1 Gene

    334 amino acids
    Molecular mass:
    37237 Da
    Quaternary structure:
    • Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner (PubMed:23396448).
    • Sequence=AAH04409.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH35721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTG1 Gene


neXtProt entry for MTG1 Gene

Post-translational modifications for MTG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTG1 Gene

Domains & Families for MTG1 Gene

Suggested Antigen Peptide Sequences for MTG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
genes like me logo Genes that share domains with MTG1: view

No data available for Gene Families for MTG1 Gene

Function for MTG1 Gene

Molecular function for MTG1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

Gene Ontology (GO) - Molecular Function for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 23396448
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with MTG1: view
genes like me logo Genes that share phenotypes with MTG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTG1 Gene

Localization for MTG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTG1 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTG1 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IDA,IEA 23396448
GO:0005759 mitochondrial matrix IDA 23396448
GO:0005761 mitochondrial ribosome IDA 23396448
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MTG1: view

Pathways & Interactions for MTG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0044065 regulation of respiratory system process IMP 23396448
GO:0070129 regulation of mitochondrial translation IMP 23396448
genes like me logo Genes that share ontologies with MTG1: view

No data available for Pathways by source and SIGNOR curated interactions for MTG1 Gene

Drugs & Compounds for MTG1 Gene

(1) Drugs for MTG1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with MTG1: view

Transcripts for MTG1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - -
SP7: -
SP8: - - -

Relevant External Links for MTG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTG1 Gene

Protein differential expression in normal tissues from HIPED for MTG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Kidney (15.2), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTG1 Gene

Protein tissue co-expression partners for MTG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTG1 Gene:


Evidence on tissue expression from TISSUES for MTG1 Gene

  • Pancreas(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with MTG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTG1 Gene

Orthologs for MTG1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MTG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTG1 34 35
  • 99.4 (n)
(Bos Taurus)
Mammalia MTG1 34 35
  • 85.94 (n)
(Canis familiaris)
Mammalia -- 35
  • 82 (a)
(Rattus norvegicus)
Mammalia Mtg1 34
  • 81.11 (n)
(Mus musculus)
Mammalia Mtg1 34 16 35
  • 79.77 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
-- 35
  • 67 (a)
(Gallus gallus)
Aves MTG1 34 35
  • 67.1 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtg1 34
  • 66.67 (n)
Str.15410 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15705 34
(Danio rerio)
Actinopterygii gtpbpl 35 34 34
  • 61.02 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13992 34
fruit fly
(Drosophila melanogaster)
Insecta CG17141 34 35
  • 54.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004736 34
  • 51.31 (n)
(Caenorhabditis elegans)
Secernentea Y67D2.4 34 35
  • 47.21 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTG1 34 35 37
  • 44.25 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL048W 34
  • 43.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02904g 34
  • 41.49 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02123 34
  • 45.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mtg1 34
  • 42.09 (n)
Species where no ortholog for MTG1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTG1 Gene

Gene Tree for MTG1 (if available)
Gene Tree for MTG1 (if available)

Paralogs for MTG1 Gene

Paralogs for MTG1 Gene

genes like me logo Genes that share paralogs with MTG1: view

Variants for MTG1 Gene

Sequence variations from dbSNP and Humsavar for MTG1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000059681 -- 133,407,142(+) CTGGT(A/C)TGTTC intron-variant
rs1000126153 -- 133,419,351(+) GCGCC(A/G)CAGTC intron-variant
rs1000245596 -- 133,399,687(+) TGCCA(C/T)CATCT intron-variant
rs1000275977 -- 133,412,958(+) TTCGT(C/G)TATTT intron-variant
rs1000496844 -- 133,394,824(+) GGCCC(C/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTG1 Gene

Variant ID Type Subtype PubMed ID
dgv1000n100 CNV gain 25217958
dgv1001n100 CNV gain 25217958
dgv123n27 CNV gain 19166990
dgv124n27 CNV gain 19166990
dgv125n27 CNV gain 19166990
dgv1486n54 CNV gain 21841781
dgv1487n54 CNV gain 21841781
dgv1488n54 CNV gain 21841781
dgv1489n54 CNV gain 21841781
dgv2e196 CNV duplication 17116639
dgv304e212 CNV gain 25503493
dgv35e55 CNV gain 17911159
dgv39n111 CNV duplication 26073780
dgv3e196 CNV duplication 17116639
dgv999n100 CNV gain 25217958
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv2760130 CNV gain+loss 21179565
esv2764146 CNV gain+loss 21179565
esv3579239 CNV loss 25503493
esv3625045 CNV gain 21293372
nsv1037772 CNV gain 25217958
nsv1043323 CNV gain 25217958
nsv1052033 CNV gain 25217958
nsv1052904 CNV gain 25217958
nsv428243 CNV gain 18775914
nsv467509 CNV loss 19166990
nsv469597 CNV gain 16826518
nsv470980 CNV loss 18288195
nsv470981 CNV gain 18288195
nsv514545 CNV gain 21397061
nsv517180 CNV gain+loss 19592680
nsv527785 CNV loss 19592680
nsv528260 CNV loss 19592680
nsv552589 CNV gain 21841781
nsv552644 CNV loss 21841781
nsv7631 CNV deletion 18451855
nsv832040 CNV loss 17160897
nsv832041 CNV gain 17160897
nsv952707 CNV deletion 24416366
nsv952708 CNV deletion 24416366

Variation tolerance for MTG1 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTG1 Gene

Disorders for MTG1 Gene

Relevant External Links for MTG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MTG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTG1 Gene

Publications for MTG1 Gene

  1. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. (PMID: 23396448) Kotani T. … Takeuchi N. (Nucleic Acids Res. 2013) 2 3 4 64
  2. MTG1 codes for a conserved protein required for mitochondrial translation. (PMID: 12808030) Barrientos A. … Tzagoloff A. (Mol. Biol. Cell 2003) 2 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for MTG1 Gene

Sources for MTG1 Gene

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